Taher Darreh-Shori

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Articles

Article: BIOORGANIC CHEMISTRY. 2024;147:107373

Synthesis and biological evaluation of Halogen-Substituted novel α-Ketoamides as potential protein aggregation modulators in Alzheimer's disease

Das B; Baidya ATK; Chakrabarti S; Chouhan D; Thakur B; Darreh-Shori T; Chen G; Tiwari V; Kumar R
Article: BMC NEUROLOGY. 2024;24(1):116

Onset of Alzheimer disease in apolipoprotein ε4 carriers is earlier in butyrylcholinesterase K variant carriers

Lane RM; Darreh-Shori T; Junge C; Li D; Yang Q; Edwards AL; Graham DL; Moore K; Mummery CJ
Article: BIOLOGY OF REPRODUCTION. 2024;110(1):63-77

Presence of key cholinergic enzymes in human spermatozoa and seminal fluid†.

Thakur B; Hasooni LP; Gera R; Mitra S; Björndahl L; Darreh-Shori T
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):137

Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App^NL-G-F knock-in Alzheimer mice

Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg LU; Darreh-Shori T; Behbahani H; Nilsson P; Eriksdotter M
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S1)

Hippocampal BDNF encapsulated cell bio‐delivery improves spontaneous behavioral alternations in the Y‐maze test in AppNL‐G‐F mice.

Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg L; Behbahani H; Darreh‐Shori T; Nilsson P; Eriksdotter M
Article: JOURNAL OF MOLECULAR STRUCTURE. 2023;1276:134782

Synthesis, single crystal X-ray, DFT, spectroscopic, molecular docking studies and in vitro biological evaluation of compound N-benzyl-4-(4-chlorophenyl)-2-oxobutanamide

Das B; Baidya ATK; Devi B; Rom T; Paul AK; Thakur B; Darreh-Shori T; Kumar R
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(4):749-765

Mechanistic Insight into the Inhibition of Choline Acetyltransferase by Proton Pump Inhibitors

Baidya ATK; Das B; Devi B; Langstroem B; agren H; Darreh-Shori T; Kumar R
Article: KIDNEY INTERNATIONAL. 2023;103(1):166-176

Association between cholinesterase inhibitors and kidney function decline in patients with Alzheimer's dementia

Xu H; Garcia-Ptacek S; Bruchfeld A; Fu EL; Shori TD; Lindholm B; Eriksdotter M; Carrero JJ
Journal article: NEUROMODULATION. 2022;25(7):s33-s34

O003 / #714 COGNITIVE RESTORATION IN ALZHEIMER’S PATIENTS BY LOCAL INTRACEREBRAL CELL-MEDIATED NERVE GROWTH FACTOR DELIVERY: CLINICAL EFFICACY AND FURTHER METHOD OPTIMIZATION ORAL POSTER PRESENTATIONS FIVE BEST ABSTRACTS

Linderoth B; Mitra S; Almqvist P; Lind G; Eyjolfsdottir H; Behbahani H; Darreh-Shori T; Ruchi G; Westman E; Seiger Å; Wahlberg L; Eriksdotter M
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(11):6073

Allosteric Binding Sites of Aβ Peptides on the Acetylcholine Synthesizing Enzyme ChAT as Deduced by In Silico Molecular Modeling

Baidya ATK; Kumar A; Kumar R; Darreh-Shori T
Journal article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2022;37(Supplement_3):gfac115.001

FC081: Cholinesterase Inhibitors and Kidney Function Decline in Patients with Alzheimer's Dementia

Xu H; Garcia-Ptacek S; Bruchfeld A; Fu E; Shori TD; Lindholm B; Eriksdotter M; Carrero JJ
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:876019

Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects

Teitsdottir UD; Darreh-Shori T; Lund SH; Jonsdottir MK; Snaedal J; Petersen PH
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:756687

Fast Alpha Activity in EEG of Patients With Alzheimer's Disease Is Paralleled by Changes in Cognition and Cholinergic Markers During Encapsulated Cell Biodelivery of Nerve Growth Factor

Eyjolfsdottir H; Koenig T; Karami A; Almqvist P; Lind G; Linderoth B; Wahlberg L; Seiger A; Darreh-Shori T; Eriksdotter M; Jelic V
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:714186

Increased Endogenous GDNF in Mice Protects Against Age-Related Decline in Neuronal Cholinergic Markers

Mitra S; Turconi G; Darreh-Shori T; Matlik K; Aquilino M; Eriksdotter M; Andressoo J-O
Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:704583

CSF and Plasma Cholinergic Markers in Patients With Cognitive Impairment

Karami A; Darreh-Shori T; Schultzberg M; Eriksdotter M
Article: BIOCHEMICAL PHARMACOLOGY. 2020;182:114212

Esomeprazole reduces sperm motility index by targeting the spermic cholinergic machinery: A mechanistic study for the association between use of proton pump inhibitors and reduced sperm motility index

Kumar A; Kumar R; Flanagan J; Langstrom B; Bjorndahl L; Darreh-Shori T
Article: ALZHEIMERS RESEARCH & THERAPY. 2020;12(1):92

Association of glial and neuronal degeneration markers with Alzheimer's disease cerebrospinal fluid profile and cognitive functions

Teitsdottir UD; Jonsdottir MK; Lund SH; Darreh-Shori T; Snaedal J; Petersen PH
Article: ALZHEIMERS & DEMENTIA. 2020;16(7):1031-1042

Proton pump inhibitors act with unprecedented potencies as inhibitors of the acetylcholine biosynthesizing enzyme-A plausible missing link for their association with incidence of dementia

Kumar R; Kumar A; Nordberg A; Langstrom B; Darreh-Shori T
Article: GENETICS AND MOLECULAR BIOLOGY. 2020;43(4):e20190404

Influence of a genetic variant of CHAT gene over the profile of plasma soluble ChAT in Alzheimer disease

Rocha-Dias PF; Simao-Silva DP; Lopes da Silva SS; Piovezan MR; Souza RKM; Darreh-Shori T; Furtado-Alle L; Rodrigues Souza RL
Article: FRONTIERS IN GENETICS. 2020;11:1022

Insulin-Independent and Dependent Glucose Transporters in Brain Mural Cells in CADASIL

Panahi M; Rodriguez PR; Fereshtehnejad S-M; Arafa D; Bogdanovic N; Winblad B; Cedazo-Minguez A; Rinne J; Darreh-Shori T; Hase Y; Kalaria RN; Viitanen M; Behbahani H
Journal article: INDIAN DRUGS. 2019;56(10):22-25

PYRAZOLINE CONTAINING MOLECULES AS MULTIFUNCTIONAL AGENTS IN ALZHEIMER’S DISEASE

Khambete M; Murumkar P; Kumar A; Darreh-Shori T; De S; Yadav MR; Degani MS
Article: ALZHEIMERS RESEARCH & THERAPY. 2019;11(1):80

Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas

Sinclair LI; Kumar A; Darreh-Shori T; Love S
Journal article: ALZHEIMERS & DEMENTIA. 2019;15(7S_Part_18):p971

P3‐108: CHAT POTENTIATING LIGANDS (CPLS): A NOVEL THERAPEUTIC STRATEGY FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Kumar A; Murumkar P; Kumar R; Yadav MR; Darreh-Shori T
Journal article: ALZHEIMERS & DEMENTIA. 2019;15(7S_Part_12):p614

P2‐109: CSF CHOLINERGIC INDEX, A NEW BIOMEASURE OF TREATMENT EFFECT IN PATIENTS WITH ALZHEIMER'S DISEASE

Karami A; Eriksdotter M; Kadir A; Almkvist O; Nordberg AK; Darreh-Shori T
Journal article: ALZHEIMERS & DEMENTIA. 2019;15(7S_Part_31):p1630

O5‐06‐06: LIGANDS OF THE CORE ACETYLCHOLINE BIOSYNTHESIZING ENZYME, CHOLINE ACETYLTRANSFERASE, AS NOVEL AND POTENTIAL THERAPEUTIC AGENTS AND IN VIVO PET TRACERS FOR EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE

Darreh-Shori T; Kumar R; Kumar A; Murumkar P; Nag S; Jia Z; Arakawa R; Leuzy A; Lemoine L; Nordberg A; Yadav MR; Halldin C; Långström B
Journal article: ALZHEIMERS & DEMENTIA. 2019;15(7S_Part_5):p269

P1‐090: DISCOVERY OF NOVEL SMALL MOLECULES FOR THE TREATMENT OF ALZHEIMER'S DISEASE

Murumkar PR; Yadav MR; Darreh-Shori T; Kumar A; Kumar R
Article: GUT. 2019;68(7):1210-1223

Changes in neuromuscular structure and functions of human colon during ageing are region-dependent

Broad J; Kung VWS; Palmer A; Elahi S; Karami A; Darreh-Shori T; Ahmed S; Thaha MA; Carroll R; Chin-Aleong J; Martin JE; Saffrey MJ; Knowles CH; Sanger GJ
Article: MOLECULAR NEUROBIOLOGY. 2019;56(7):4601-4619

Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain

Darreh-Shori T; Rezaeianyazdi S; Lana E; Mitra S; Gellerbring A; Karami A; Bogdanovic N; Lithner CU; Winblad B; Behbahani H
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:176

Homomeric and Heteromeric Aβ Species Exist in Human Brain and CSF Regardless of Alzheimer's Disease Status and Risk Genotype

Lana E; Gellerbring A; Jung S; Nordberg A; Lithner CU; Darreh-Shori T
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2019;12:239

CSF Cholinergic Index, a New Biomeasure of Treatment Effect in Patients With Alzheimer's Disease

Karami A; Eriksdotter M; Kadir A; Almkvist O; Nordberg A; Darreh-Shori T
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_7):p371

P1‐241: SOLUBLE AMYLOID‐BETA ACTIVATES CHOLINE ACETYLTRANSFERASE

Kumar A; Lana E; Kumar R; Lithner CU; Darreh-Shori T
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_4):p261

P1‐001: CSF CHOLINE ACETYLTRANSFERASE SHOWS DIFFERENTIAL LEVELS AMONG HEALTHY CONTROLS AND PATIENTS WITH AD AND MCI

Karami A; Darreh-Shori T; Zetterberg H; Blennow K; Eriksdotter M
Journal article: ALZHEIMERS & DEMENTIA. 2018;14(7S_Part_21):p1147-p1148

P3‐207: ARE VISUAL HALLUCINATIONS IN ALZHEIMER'S DISEASE A RESULT OF HYPOPERFUSION OF VISUAL PROCESSING AREAS IN THE OCCIPITAL CORTEX?

Sinclair LI; Darreh-Shori T; Mandagere V; Love S
Article: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2018;11:327

Soluble Aβ42 Acts as Allosteric Activator of the Core Cholinergic Enzyme Choline Acetyltransferase

Kumar A; Lana E; Kumar R; Lithner CU; Darreh-Shori T
Article: ACS CHEMICAL NEUROSCIENCE. 2017;8(12):2618-2625

DMSO: A Mixed-Competitive Inhibitor of Human Acetylcholinesterase

Kumar A; Darreh-Shori T
Article: SCIENTIFIC REPORTS. 2017;7(1):16287

Discovery of novel choline acetyltransferase inhibitors using structure-based virtual screening

Kumar R; Kumar A; Langstrom B; Darreh-Shori T
Journal article: ALZHEIMERS & DEMENTIA. 2017;13(7S_Part_14):p696

[P2–224]: NOVEL LIGANDS OF CHOLINE ACETYLTRANSFERASE AND CHOLINESTERASES: DRUG‐REPURPOSING STRATEGIES AND IDENTIFICATION OF POTENTIAL PET TRACERS AS IN VIVO BIOMARKERS

Kumar A; Kumar R; Darreh‐Shori T
Article: SCIENTIFIC REPORTS. 2016;6:31247

Novel ligands of Choline Acetyltransferase designed by in silico molecular docking, hologram QSAR and lead optimization

Kumar R; Langstrom B; Darreh-Shori T
Article: ALZHEIMERS RESEARCH & THERAPY. 2016;8(1):30

Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device

Eyjolfsdottir H; Eriksdotter M; Linderoth B; Lind G; Juliusson B; Kusk P; Almkvist O; Andreasen N; Blennow K; Ferreira D; Westman E; Nennesmo I; Karami A; Darreh-Shori T; Kadir A; Nordberg A; Sundstrom E; Wahlund L-O; Wall A; Wiberg M; Winblad B; Seiger A; Wahlberg L; Almqvist P
Article: JOURNAL OF ALZHEIMERS DISEASE. 2016;50(2):567-576

Association of Butyrylcholinesterase-K Allele and Apolipoprotein E ε4 Allele with Cognitive Decline in Dementia with Lewy Bodies and Alzheimer's Disease

Vijayaraghavan S; Darreh-Shori T; Rongve A; Berge G; Sando SB; White LR; Auestad BH; Witoelar A; Andreassen OA; Ulstein ID; Aarsland D
Article: BRAIN. 2016;139(Pt 1):174-192

Amyloid-β peptides act as allosteric modulators of cholinergic signalling through formation of soluble BAβACs

Kumar R; Nordberg A; Darreh-Shori T
Article: ALZHEIMERS & DEMENTIA. 2015;11(11):1316-1328

Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease

Karami A; Eyjolfsdottir H; Vijayaraghavan S; Lind G; Almqvist P; Kadir A; Linderoth B; Andreasen N; Blennow K; Wall A; Westman E; Ferreira D; Wiberg MK; Wahlund L-O; Seiger A; Nordberg A; Wahlberg L; Darreh-Taher T; Eriksdotter M
Article: PLOS ONE. 2015;10(4):e0122048

Complement Component C3 and Butyrylcholinesterase Activity Are Associated with Neurodegeneration and Clinical Disability in Multiple Sclerosis

Aeinehband S; Lindblom RPF; Al Nimer F; Vijayaraghavan S; Sandholm K; Khademi M; Olsson T; Nilsson B; Ekdahl KN; Darreh-Shori T; Piehl F
Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;43(3):1059-1072

Brain Changes in Alzheimer's Disease Patients with Implanted Encapsulated Cells Releasing Nerve Growth Factor

Ferreira D; Westman E; Eyjolfsdottir H; Almqvist P; Lind G; Linderoth B; Seiger A; Blennow K; Karami A; Darreh-Shori T; Wiberg M; Simmons A; Wahlund L-O; Wahlberg L; Eriksdotter M
Article: ALZHEIMERS & DEMENTIA. 2014;10(5):530-540.e1

High apolipoprotein E in cerebrospinal fluid of patients with Lewy body disorders is associated with dementia

Vijayaraghavan S; Maetzler W; Reimold M; Lithner CU; Liepelt-Scarfone I; Berg D; Darreh-Shori T
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2014;18(9):1874-1888

Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation

Malmsten L; Vijayaraghavan S; Hovatta O; Marutle A; Darreh-Shori T
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_3):p215

O3‐04‐02: EPIGENETIC MODIFICATIONS IN ALZHEIMER'S DISEASE: EFFECTS OF BETA‐AMYLOID EXPOSURE

Lana E; Chen X; Jung S; Wiehager B; Ankarcrona M; Darreh‐Shori T; Lithner CU
Journal article: ALZHEIMERS & DEMENTIA. 2014;10(4S_Part_17):p620

P2‐387: NGF CELL THERAPY IN AD PATIENTS: EFFECTS ON CSF CHOLINERGIC BIOMARKERS

Karami A; Eyjolfsdottir H; Vijayaraghavan S; Lind G; Per A; Kadir A; Linderoth B; Andreasen N; Nordberg A; Wall A; Wahlund L; Seiger Å; Wahlberg L; Darreh‐Shori T; Eriksdotter M
Article: JOURNAL OF IMMUNOLOGY. 2014;192(3):1138-1153

Unbiased Expression Mapping Identifies a Link between the Complement and Cholinergic Systems in the Rat Central Nervous System

Lindblom RPF; Stroem M; Heinig M; Al Nimer F; Aeinehband S; Berg A; Dominguez CA; Vijayaraghavan S; Zhang X-M; Harnesk K; Zelano J; Huebner N; Cullheim S; Darreh-Shori T; Diez M; Piehl F
Article: JOURNAL OF ALZHEIMERS DISEASE. 2014;39(2):423-440

Pharmacodynamics of Cholinesterase Inhibitors Suggests Add-on Therapy with a Low-Dose Carbamylating Inhibitor in Patients on Long-Term Treatment with Rapidly Reversible Inhibitors

Darreh-Shori T; Hosseini SM; Nordberg A
Article: NEUROBIOLOGY OF AGING. 2013;34(11):2465-2481

Functional variability in butyrylcholinesterase activity regulates intrathecal cytokine and astroglial biomarker profiles in patients with Alzheimer's disease

Darreh-Shori T; Vijayaraghavan S; Aeinehband S; Piehl F; Lindblom RPF; Nilsson B; Ekdahl KN; Langstrom B; Almkvist O; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2013;9(4S_Part_13):p547-p548

O3–13–01: Low‐grade inflammatory processes stimulate regenerative mechanisms in Alzheimer's disease

Malmsten L; Lilja A; Rojdner J; Voytenko L; Vijayaraghavana S; Hovatta O; Darreh‐Shori T; Nordberg A; Marutle A
Article: INTERNATIONAL JOURNAL OF ALZHEIMER'S DISEASE. 2013;2013:473181-2

Biomarkers in Alzheimer's disease and lewy body disorders with dementia.

Leyhe T; Darreh-Shori T; Laske C; Mielke MM; Maetzler W
Article: THE PRIMARY CARE COMPANION FOR CNS DISORDERS. 2013;15(2):PCC.12r01412

A review of butyrylcholinesterase as a therapeutic target in the treatment of Alzheimer's disease.

Nordberg A; Ballard C; Bullock R; Darreh-Shori T; Somogyi M
Article: PLOS ONE. 2013;8(6):e65936

Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway

Vijayaraghavan S; Karami A; Aeinehband S; Behbahani H; Grandien A; Nilsson B; Ekdahl KN; Lindblom RPF; Piehl F; Darreh-Shori T
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;28(2):443-458

Apolipoprotein ε4 Modulates Phenotype of Butyrylcholinesterase in CSF of Patients with Alzheimer's Disease

Darreh-Shori T; Siawesh M; Mousavi M; Andreasen N; Nordberg A
Article: NEUROBIOLOGY OF AGING. 2011;32(12):2320.e15-2320.e32

Differential levels of apolipoprotein E and butyrylcholinesterase show strong association with pathological signs of Alzheimer's disease in the brain in vivo

Darreh-Shori T; Forsberg A; Modiri N; Andreasen N; Blennow K; Kamil C; Ahmed H; Almkvist O; Langstrom B; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_12):s416

P2‐332: The influence of beta‐amyloid 1‐42 on inflammatory processes and regenerative mechanisms in Alzheimer's disease

Wicklund L; Marutle A; Hertwig L; Hovatta O; Nordberg A; Darreh‐Shori T
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_12):s407

P2‐303: Impact of Butyrylcholinesterase K genotype on glial and proinflammatory markers in CSF of patients with Alzheimer's disease.

Darreh‐Shori T; Bälter M; Siawesh M; Nordberg A
Article: NEUROBIOLOGY OF AGING. 2011;32(7):1236-1248

The apolipoprotein E ε4 allele plays pathological roles in AD through high protein expression and interaction with butyrylcholinesterase

Darreh-Shori T; Modiri N; Blennow K; Baza S; Kamil C; Ahmed H; Andreasen N; Nordberg A
Article: BRAIN. 2011;134(Pt 1):301-317

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer's disease

Kadir A; Marutle A; Gonzalez D; Scholl M; Almkvist O; Mousavi M; Mustafiz T; Darreh-Shori T; Nennesmo I; Nordberg A
Article: CURRENT ALZHEIMER RESEARCH. 2010;7(1):67-73

Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimer's Disease: A Review of Recent Clinical Studies

Darreh-Shori T; Soininen H
Journal article: CLINICAL MEDICINE INSIGHTS: THERAPEUTICS. 2010;2:cmt.s5410

Donepezil: A Review of Pharmacological Characteristics and Role in the Management of Alzheimer Disease

Jelic V; Darreh-Shori T
Article: DEMENTIA AND GERIATRIC COGNITIVE DISORDERS. 2010;29(3):204-212

Pittsburgh Compound-B and Alzheimer's Disease Biomarkers in CSF, Plasma and Urine: An Exploratory Study

Gunnarsson MD; Lindau M; Wall A; Blennow K; Darreh-Shori T; Basu S; Nordberg A; Larsson A; Lannfelt L; Basun H; Kilander L
Journal article: CURRENT ALZHEIMER RESEARCH. 2009;999(999):1-6

Effects of Cholinesterase Inhibitors on the Activities and Protein Levels of Cholinesterases in the Cerebrospinal Fluid of Patients with Alzheimer's disease: A Review of Recent Clinical Studies

Darreh-Shori T
Article: PHARMACOGENETICS AND GENOMICS. 2009;19(8):635-646

Progression from mild cognitive impairment to Alzheimer's disease: effects of sex, butyrylcholinesterase genotype, and rivastigmine treatment

Ferris S; Nordberg A; Soininen H; Darreh-Shori T; Lane R
Journal article: ALZHEIMERS & DEMENTIA. 2009;5(4S_Part_11):p332

P2‐246: Effects of rivastigmine on brain white matter volume in Mild Cognitive Impairment (MCI)

Ferris S; Darreh‐Shori T; Lane R
Journal article: ALZHEIMERS & DEMENTIA. 2009;5(4S_Part_10):p305

P2‐151: ApoE and amyloid beta deflate the cholinergic neurotransmission by boosting the activity and stability of cholinesterases in the brain

Darreh‐Shori T; Modiri N; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2009;5(4S_Part_7):p225

P1‐163: Apolipoprotein E and Butyrylcholinesterase synergistically promote Ab peptides oligomerization

Darreh‐Shori T; Modiri N; Nordberg A
Article: CURRENT ALZHEIMER RESEARCH. 2009;6(3):290-292

Safety of Lumbar Puncture Procedures in Patients with Alzheimer's Disease

Peskind E; Nordberg A; Darreh-Shori T; Soininen H
Article: CURRENT ALZHEIMER RESEARCH. 2009;6(1):4-14

Different Cholinesterase Inhibitor Effects on CSF Cholinesterases in Alzheimer Patients

Nordberg A; Darreh-Shori T; Peskind E; Soininen H; Mousavi M; Eagle G; Lane R
Article: NEUROBIOLOGY OF AGING. 2008;29(8):1204-1217

PET imaging of the in vivo brain acetylcholinesterase activity and nicotine binding in galantamine-treated patients with AD

Kadir A; Darreh-Shori T; Almkvist O; Wall A; Grut M; Strandberg B; Ringheim A; Eriksson B; Blomquist G; Langstrom B; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_18):t608

P3‐293: Interaction between amyloid‐beta peptides with butyrylcholinesterase and ApoE proteins: Mechanism of amyloid fibrils deposition in the brain of patients with Alzheimer's disease

Darreh-Shori T; Forsberg A; Andreasen N; Blennow K; Wall A; Kamil C; Långström B; Nordberg A
Article: PHARMACOGENETICS AND GENOMICS. 2008;18(4):289-298

Synergistic effect of apolipoprotein E ε4 and butyrylcholinesterase K-variant on progression from mild cognitive impairment to Alzheimer's disease

Lane R; Feldman HH; Meyer J; He Y; Ferris SH; Nordberg A; Darreh-Shori T; Soininen H; Pirttila T; Farlow MR; Sfikas N; Ballard C; Greig NH
Article: NEUROBIOLOGY OF AGING. 2008;29(2):168-184

Inhibition of acetylcholinesterase in CSF versus brain assessed by ¹¹C-PMP PET in AD patients treated with galantamine

Darreh-Shori T; Kadir A; Almkvist O; Grut M; Wall A; Blomquist G; Eriksson B; Langstrom B; Nordberg A
Article: PSYCHOPHARMACOLOGY. 2007;191(4):1005-1014

Changes in brain ¹¹C-nicotine binding sites in patients with mild Alzheimer's disease following rivastigmine treatment as assessed by PET

Kadir A; Darreh-Shori T; Almkvist O; Wall A; Langstrom B; Nordberg A
Article: JOURNAL OF NEURAL TRANSMISSION. 2006;113(11):1791-1801

Changes in the activity and protein levels of CSF acetylcholinesterases in relation to cognitive function of patients with mild Alzheimer's disease following chronic donepezil treatment

Darreh-Shori T; Meurling L; Pettersson T; Hugosson K; Hellstrom-Lindahl E; Andreasen N; Minthon L; Nordberg A
Article: NEUROBIOLOGY OF DISEASE. 2006;24(2):326-333

Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE ε4 allele, in relation to cognitive function and cerebral glucose metabolism

Darreh-Shori T; Brimijoin S; Kadir A; Almkvist O; Nordberg A
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_9):s273

P2–136: Differential CSF butyrylcholinesterase levels in Alzheimer's disease patients with the ApoE ϵ4 allele, in relation to cognitive function and cerebral glucose metabolism

Darreh-Shori T; Brimijoin S; Kadir A; Almkvist O; Nordberg A
Article: EUROPEAN JOURNAL OF NEUROLOGY. 2004;11(4):253-261

Preserved cognitive function after 12 months of treatment with rivastigmine in mild Alzheimer's disease in comparison with untreated AD and MCI patients

Almkvist O; Darreh-Shori T; Stefanova E; Spiegel R; Nordberg A
Article: JOURNAL OF NEUROCHEMISTRY. 2004;88(5):1102-1113

Long-lasting acetylcholinesterase splice variations in anticholinesterase-treated Alzheimer's disease patients

Darreh-Shori T; Hellström-Lindahl E; Flores-Flores C; Guan ZZ; Soreq H; Nordberg A
Article: NEUROLOGY. 2002;59(4):563-572

Sustained cholinesterase inhibition in AD patients receiving rivastigmine for 12 months

Darreh-Shori T; Almkvist O; Guan ZZ; Garlind A; Strandberg B; Svensson AL; Soreq H; Hellström-Lindahl E; Nordberg A
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;54(1-2):180-189

Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different FLIP isoforms

Djerbi M; Darreh-Shori T; Zhivotovsky B; Grandien A
Journal article: NEUROBIOLOGY OF AGING. 2000;21:243

Long term rivastigmine treatment produces persistent inhibition of acetyl- and butyrylcholinesterase activity in CSF of Alzheimer's patients

Darreh-Shori T; Svensson A-L; Nordberg A
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All other publications

Preprint: RESEARCH SQUARE. 2020

Association of glial and neuronal degeneration markers with Alzheimer‘s disease cerebrospinal fluid profile and cognitive functions

Teitsdottir UD; Jonsdottir MK; Lund SH; Darreh-Shori T; Snaedal J; Petersen PH
Preprint: RESEARCH SQUARE. 2020

Association of glial and neuronal degeneration markers with Alzheimer‘s disease cerebrospinal fluid profile and cognitive functions

Teitsdottir UD; Jonsdottir MK; Lund SH; Darreh-Shori T; Snaedal J; Petersen PH
Conference publication: JOURNAL OF NEUROCHEMISTRY. 2017;142:214

Amyloid beta peptides act as allosteric modulators of cholinesterases

Kumar R; Darreh-Shori T
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2017;253

Hologram QSAR and structure-based design of novel small-molecule inhibitors of choline acetyltransferase

Kumar R; Darreh-Shori T
Conference publication: NEUROBIOLOGY OF AGING. 2016;39:S29

NEW LIGANDS OF CHOLINE ACETYLTRANSFERASE AS THERAPEUTICS AND IN VIVO FUNCTIONAL BIOMARKERS IN ALZHEIMER'S DISEASE

Darreh-Shori T
Review: JOURNAL OF ALZHEIMERS DISEASE. 2015;44(4):1039-1062

Understanding the Beneficial and Detrimental Effects of Donepezil and Rivastigmine to Improve their Therapeutic Value

Lane RM; Darreh-Shori T
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2015;249

Molecular modeling studies of choline acetyltransferase inhibitors as potential PET probes

Kumar R; Darreh-Shori T
Meeting abstract: NEUROBIOLOGY OF AGING. 2012;33:S6

THE RELATIONSHIP BETWEEN CHOLINESTERASES AND AD PATHOLOGY

Darreh-Shori T
Conference publication: EUROPEAN JOURNAL OF NEUROLOGY. 2012;19:91

Cell therapy with NGF in patients with Alzheimer's disease: changes in CSF cholinergic markers

Karami A; Eyjolfsdottir H; Vijayaraghavan S; Kadir A; Linderoth B; Lind G; Andreasen N; Wall A; Seiger A; Almqvist P; Wahlberg L; Nordberg A; Darreh-Shori T; Eriksdotter M
Review: EXPERT OPINION ON DRUG SAFETY. 2010;9(1):167-176

Safety and tolerability of transdermal and oral rivastigmine in Alzheimer's disease and Parkinson's disease dementia

Darreh-Shori T; Jelic V
Thesis / dissertation: 2006

Molecular changes of acetylcholinesterase and butyrylcholinesterase in Alzheimer patients during the natural couse of the disease and treatment with cholinesterase inhibitors : insight into neurochemical mechanisms affecting the progression of the disease

Darreh-Shori, Taher
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S375

Long-term changes in the protein levels of different acetylcholinesterase (ACHE) isoforms in cerebrospinal fluid (CSF) of rivastigmine and tacrine treated AD patients

Darreh-Shori T; Nordberg A; Hellström-Lindahl E; Flores-Flores C; Soreq H

Grants

Investigating the potential of combination therapies targeting the cholinergic system in Alzheimer´s disease

Swedish Research Council

1 January 2021 - 31 December 2023
Gene Knock Up via 3’UTR targeting to treat Alzheimer’s disease

Swedish Research Council

1 January 2020 - 31 December 2022
Targeting the core cholinergic cells for development of biomarkers and therapeutic strategies in Alzheimer´s disease

Swedish Research Council

1 January 2017 - 31 December 2020
The revival of the cholinergic system in Alzheimer´s disease - Cognitive impairment, cognitive restoration and early diagnosis in Alzheimer´s disease

Swedish Research Council

1 January 2017 - 31 December 2020
Novel Lead ChAT-PET tracer as early diagnostic and theragonistic biomarker

Alzheimer's Association

1 January 2016

Employments

Principal Researcher, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2014
Doctor Of Philosophy, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, 2006

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