Stefanie Prast-Nielsen

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Docent i medicinsk mikrobiologi
Senior forskningsspecialist i multiomics, maskininlärning och dataintegration vid Centre for Translational Microbiome Research
Doktor i Medicinsk biokemi
För mer information, vänligen besök den engelska versionen av webbplatsen.

Artiklar

Journal article: EBIOMEDICINE. 2024;109:105400
Association between seizure reduction during ketogenic diet treatment of epilepsy and changes in circulatory metabolites and gut microbiota composition.
Dahlin M; Wheelock CE; Prast-Nielsen S
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2024;59(6):674-682
Plasma bile acids in association with Crohn's disease
Kiasat A; Prast-Nielsen S; Rautiainen S; Engstrand L; Andersson F; Lindberg J; Schuppe-Koistinen I; Granstrom AL; Gustafsson UO
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2024;117:298-309
Differences in the gut microbiome of young adults with schizophrenia spectrum disorder: using machine learning to distinguish cases from controls
Stiernborg M; Prast-Nielsen S; Melas PA; Skott M; Millischer V; Boulund F; Forsell Y; Lavebratt C
Article: SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY. 2023;58(11):1246-1252
Evaluation of plasma Short chain fatty acid levels as markers for Inflammatory bowel disease
Kiasat A; Rautiainen S; Prast-Nielsen S; Engstrand L; Schuppe-Koistinen I; Gustafsson UOO; Granstrom AL
Article: JOURNAL OF CROHN'S AND COLITIS. 2023;17(3):418-432
Mucosal and Plasma Metabolomes in New-onset Paediatric Inflammatory Bowel Disease: Correlations with Disease Characteristics and Plasma Inflammation Protein Markers
Nystrom N; Prast-Nielsen S; Correia M; Globisch D; Engstrand L; Schuppe-Koistinen I; Halfvarsond J
Article: EBIOMEDICINE. 2022;80:104061
Higher levels of Bifidobacteria and tumor necrosis factor in children with drug-resistant epilepsy are associated with anti-seizure response to the ketogenic diet
Dahlin M; Singleton SS; David JA; Basuchoudhary A; Wickstrom R; Mazumder R; Prast-Nielsen S
Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 2022;106(3):132-140
Influence of FLG loss-of-function mutations in host-microbe interactions during atopic skin inflammation
Olah P; Szlavicz E; Kuchner M; Nemmer J; Zeeuwen P; Lefevre-Utile A; Fyhrquist N; Prast-Nielsen S; Skoog T; Serra A; Rodriguez E; Raap U; Meller S; Gyulai R; Hupe P; Kere J; Levi-Schaffer F; Tsoka S; Alexander H; Nestle FO; Schroeder JM; Weidinger S; van den Bogaard E; Soumelis V; Greco D; Barker J; Lauerma A; Ranki A; Andersson B; Alenius H; Homey B
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;77(5):1486-1498
Transcriptome-based identification of novel endotypes in adult atopic dermatitis
Lefevre-Utile A; Saichi M; Olah P; Delord M; Homey B; Soumelis V
Article: INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES. 2021;111:313-321
Alterations of gut microbiota in patients with active pulmonary tuberculosis in China: a pilot study
Shi W; Hu Y; Ning Z; Xia F; Wu M; Hu YOO; Chen C; Prast-Nielsen S; Xu B
Article: BMC PULMONARY MEDICINE. 2019;19(1):211
Longitudinal profiling of gut microbiome among tuberculosis patients under anti-tuberculosis treatment in China: protocol of a prospective cohort study
Shi W; Hu Y; Zheng X; Ning Z; Wu M; Xia F; Prast-Nielsen S; Hu YOO; Xu B
Article: NATURE COMMUNICATIONS. 2019;10(1):4703
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist N; Muirhead G; Prast-Nielsen S; Jeanmougin M; Olah P; Skoog T; Jules-Clement G; Feld M; Barrientos-Somarribas M; Sinkko H; van den Bogaard EH; Zeeuwen PLJM; Rikken G; Schalkwijk J; Niehues H; Daeubener W; Eller SK; Alexander H; Pennino D; Suomela S; Tessas I; Lybeck E; Baran AM; Darban H; Gangwar RS; Gerstel U; Jahn K; Karisola P; Yan L; Hansmann B; Katayama S; Meller S; Bylesjo M; Hupe P; Levi-Schaffer F; Greco D; Ranki A; Schroeder JM; Barker J; Kere J; Tsoka S; Lauerma A; Soumelis V; Nestle FO; Homeyl B; Andersson B; Alenius H
Journal article: BRITISH JOURNAL OF DERMATOLOGY. 2019;181(3):e72
Investigation of the skin microbiome
Prast‐Nielsen S; Tobin A; Adamzik K; Powles A; Hugerth LW; Sweeney C; Kirby B; Engstrand L; Fry L
Journal article: BRITISH JOURNAL OF DERMATOLOGY. 2019;181(3):e84
皮肤微生物组检查
Prast‐Nielsen S; Tobin A; Adamzik K; Powles A; Hugerth LW; Sweeney C; Kirby B; Engstrand L; Fry L
Article: BRITISH JOURNAL OF DERMATOLOGY. 2019;181(3):572-579
Investigation of the skin microbiome: swabs vs. biopsies
Prast-Nielsen S; Tobin A-M; Adamzik K; Powles A; Hugerth LW; Sweeney C; Kirby B; Engstrand L; Fry L
Article: NPJ BIOFILMS AND MICROBIOMES. 2019;5(1):5
The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy
Lindefeldt M; Eng A; Darban H; Bjerkner A; Zetterstrom CK; Allander T; Andersson B; Borenstein E; Dahlin M; Prast-Nielsen S
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(9):1114-1123
Inhibition of thioredoxin reductase 1 by porphyrins and other small molecules identified by a high-throughput screening assay
Prast-Nielsen S; Dexheimer TS; Schultz L; Stafford WC; Cheng Q; Xu J; Jadhav A; Arner ESJ; Simeonov A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2010;49(11):1765-1778
Noble metal targeting of thioredoxin reductase - covalent complexes with thioredoxin and thioredoxin-related protein of 14 kDa triggered by cisplatin
Prast-Nielsen S; Cebula M; Pader I; Arner ESJ
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2009;47(11):1661-1671
High levels of thioredoxin reductase 1 modulate drug-specific cytotoxic efficacy
Eriksson SE; Prast-Nielsen S; Flaberg E; Szekely L; Arner ESJ
Article: JOURNAL OF MEDICINAL CHEMISTRY. 2009;52(20):6474-6483
Structure Mechanism Insights and the Role of Nitric Oxide Donation Guide the Development of Oxadiazole-2-Oxides as Therapeutic Agents against Schistosomiasis
Rai G; Sayed AA; Lea WA; Luecke HF; Chakrapani H; Prast-Nielsen S; Jadhav A; Leister W; Shen M; Inglese J; Austin CP; Keefer L; Arner ESJ; Simeonov A; Maloney DJ; Williams DL; Thomas CJ
Article: PLOS ONE. 2008;3(4):e1846
Cell Death by SecTRAPs: Thioredoxin Reductase as a Prooxidant Killer of Cells
Anestal K; Prast-Nielsen S; Cenas N; Arner ESJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(9):5593-5603
Interactions of nitroaromatic compounds with the mammalian selenoprotein thioredoxin reductase and the relation to induction of apoptosis in human cancer cells
Cenas N; Prast S; Nivinskas H; Sarlauskas J; Arnér ESJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;327(3):774-779
Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release
Enoksson M; Fernandes AP; Prast S; Lillig CH; Hohngren A; Orrenius S
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Alla övriga publikationer

Preprint: BIORXIV. 2024
Profiling the intestinal microbiota, plasma bile acids and inflammation markers reveals novel associations in Crohn’s disease and Ulcerative colitis
Prast-Nielsen S; Granström AL; Kiasat A; Ahlström G; Edfeldt G; Rautiainen S; Boulund F; Andersson FO; Lindberg J; Schuppe-Koistinen I; Gustafsson UO; Engstrand L
Editorial comment: CELL REPORTS. 2023;42(12):113570
Preview Fecal transfers from children on the ketogenic diet mimic the anti-seizure effect in mice
Prast-Nielsen S
Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;206(12):1564-1567
Metatranscriptomics of Nasopharyngeal Microbiota and Host Distinguish between Pneumonia and Health
Nannapaneni P; Sundh J; Prast-Nielsen S; Rhedin S; Ortqvist A; Naucler P; Henriques-Normark B
Review: PROGRESS IN MOLECULAR BIOLOGY AND TRANSLATIONAL SCIENCE. 2020;176:141-178
Bioinformatics and machine learning in gastrointestinal microbiome research and clinical application
Hopson LM; Singleton SS; David JA; Basuchoudhary A; Prast-Nielsen S; Klein P; Sen S; Mazumder R
Review: EBIOMEDICINE. 2019;44:741-746
The gut microbiome and epilepsy
Dahlin M; Prast-Nielsen S
Conference publication: HELICOBACTER. 2019;24
Study of the impact of Helicobacter pylori eradication treatments on the intestinal microbiota
McNicholl AG; Prast-Nielsen S; Andersen LP; Machado JC; Leja M; Alarcon T; Gasbarrini A; Megraud F; O'Morain C; Engstrand L; Gisbert JP
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2016;83(5):380-381
Microbe-host interplay in atopic dermatitis and psoriasis
Fyhrquist N; Andersson B; Kere J; Muirhead G; Prast-Nielsen S; Jeanmougin M; Barker J; Lauerma A; Homey B; Schroeder J; Soumelis V; Nestle F; Alenius H
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1810(12):1262-1271
Thioredoxin glutathione reductase: Its role in redox biology and potential as a target for drugs against neglected diseases
Prast-Nielsen S; Huang H-H; Williams DL
Thesis / dissertation: 2009
Exploring thioredoxin reductase as an anticancer drug target
Prast-Nielsen, Stefanie
Conference publication: CANCER RESEARCH. 2009;69
Evaluation of plain platinum, palladium and gold salts as inhibitors of mammalian thioredoxin reductase: Implications for clinically used drugs and the development of new anticancer agents
Prast-Nielsen S; Arner E
Conference publication: FREE RADICAL RESEARCH. 2009;43:63
Drug-specific responses to cytotoxic agents mediated by high levels of thioredoxin reductase 1 in human A549 cancer cells
Eriksson S; Prast-Nielsen S; Flaberg E; Szekely L; Arner E

Anställningar

Senior Forskningsspecialist, Klinisk neurovetenskap, Karolinska Institutet, 2024-2025
Senior Forskningsspecialist, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2024-2025
Senior Forskningsspecialist, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2023-2024

Examina och utbildning

Docent, Mikrobiologi inom det medicinska området, Karolinska Institutet, 2023
Medicine Doktorsexamen, Institutionen för medicinsk biokemi och biofysik, Karolinska Institutet, 2009

Om mig

Artiklar

Alla övriga publikationer

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI