Staffan Normark

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(47):e2108244118
THCz: Small molecules with antimicrobial activity that block cell wall lipid intermediates
Reithuber E; Wixe T; Ludwig KC; Muller A; Uvell H; Grein F; Lindgren AEG; Muschiol S; Nannapaneni P; Eriksson A; Schneider T; Normark S; Henriques-Normark B; Almqvist F; Mellroth P
Article: MBIO. 2020;11(6):e03027-e03020
The Bactericidal Fatty Acid Mimetic 2CCA-1 Selectively Targets Pneumococcal Extracellular Polyunsaturated Fatty Acid Metabolism
Reithuber E; Nannapaneni P; Rzhepishevska O; Lindgren AEG; Ilchenko O; Normark S; Almqvist F; Henriques-Normark B; Mellroth P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(49):31386-31397
Capillary leakage provides nutrients and antioxidants for rapid pneumococcal proliferation in influenza-infected lower airways
Sender V; Hentrich K; Pathak A; Ler ATQ; Embaie BT; Lundstrom SL; Gaetani M; Bergstrand J; Nakamoto R; Sham L-T; Widengren J; Normark S; Henriques-Normark B
Journal article: MBIO. 2020;11(6):e02809-e02820
Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa (vol 11, e01774-20, 2020)
Vidaillac C; Yong VFL; Aschtgen M-S; Qu J; Yang S; Xu G; Seng ZJ; Brown AC; Ali MK; Jaggi TK; Sankaran J; Foo YH; Righetti F; Nedumaran AM; Mac Aogain M; Roizman D; Richard J-A; Rogers TR; Toyofuku M; Luo D; Loh E; Wohland T; Czarny B; Horvat JC; Hansbro PM; Yang L; Li L; Normark S; Henriques-Normark B; Chotirmall SH
Article: MBIO. 2020;11(5):e01774-e01720
Sex Steroids Induce Membrane Stress Responses and Virulence Properties in Pseudomonas aeruginosa
Vidaillac C; Yong VFL; Aschtgen M-S; Qu J; Yang S; Xu G; Seng ZJ; Brown AC; Ali MK; Jaggi TK; Sankaran J; Foo YH; Righetti F; Nedumaran AM; Mac Aogain M; Roizman D; Richard J-A; Rogers TR; Toyofuku M; Luo D; Loh E; Wohland T; Czarny B; Horvat JC; Hansbro PM; Yang L; Li L; Normark S; Normark BH; Chotirmall SH
Journal article: JOURNAL OF INTERNAL MEDICINE. 2020;287(3):336-338
The rise of hyper-virulence
Aschtgen M-S; Henriques-Normark B; Normark S
Article: MBIO. 2016;7(5):e01783-e01716
Impact of AmpC Derepression on Fitness and Virulence: the Mechanism or the Pathway?
Perez-Gallego M; Torrens G; Castillo-Vera J; Moya B; Zamorano L; Cabot G; Hultenby K; Alberti S; Mellroth P; Henriques-Normark B; Normark S; Oliver A; Juan C
Journal article: CELL HOST & MICROBE. 2015;18(4):390-391
Streptococcal M1 Strikes by Neutralizing Cathelicidins
Henriques-Normark B; Normark S
Article: BIOESSAYS. 2015;37(4):426-435
Uptake of extracellular DNA: Competence induced pili in natural transformation of Streptococcus pneumoniae
Muschiol S; Balaban M; Normark S; Henriques-Normark B
Journal article: NPJ BIOFILMS AND MICROBIOMES. 2015;1:15004
Introducing npj Biofilms and Microbiomes
Normark S
Journal article: JOURNAL OF INTERNAL MEDICINE. 2014;276(2):98-110
Microbial biofilm formation: a need to act
Romling U; Kjelleberg S; Normark S; Nyman L; Uhlin BE; Akerlund B
Article: JOURNAL OF INFECTIOUS DISEASES. 2014;210(1):4-13
Emergence of Hypervirulent Mutants Resistant to Early Clearance During Systemic Serotype 1 Pneumococcal Infection in Mice and Humans
Syk A; Norman M; Fernebro J; Gallotta M; Farmand S; Sandgren A; Normark S; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(7):E758-E765
Secretion of a pneumococcal type II secretion system pilus correlates with DNA uptake during transformation
Balaban M; Battig P; Muschiol S; Tirier SM; Wartha F; Normark S; Henriques-Normark B
Article: MBIO. 2014;5(1):e01120-e01113
Structural and Functional Insights into Peptidoglycan Access for the Lytic Amidase LytA of Streptococcus pneumoniae
Mellroth P; Sandalova T; Kikhney A; Vilaplana F; Hesek D; Lee M; Mobashery S; Normark S; Svergun D; Henriques-Normark B; Achour A
Article: JOURNAL OF INFECTIOUS DISEASES. 2014;209(3):377-388
Intraclonal Variations Among Streptococcus pneumoniae Isolates Influence the Likelihood of Invasive Disease in Children
Browall S; Norman M; Tangrot J; Galanis I; Sjostrom K; Dagerhamn J; Hellberg C; Pathak A; Spadafina T; Sandgren A; Battig P; Franzen O; Andersson B; Ortqvist A; Normark S; Henriques-Normark B
Article: OPEN BIOLOGY. 2014;4(1):130090
The basic keratin 10-binding domain of the virulence-associated pneumococcal serine-rich protein PsrP adopts a novel MSCRAMM fold
Schulte T; Lofling J; Mikaelsson C; Kikhney A; Hentrich K; Diamante A; Ebel C; Normark S; Svergun D; Henriques-Normark B; Achour A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(50):20230-20235
Focal targeting by human β-defensin 2 disrupts localized virulence factor assembly sites in Enterococcus faecalis
Kandaswamy K; Liew TH; Wang CY; Huston-Warren E; Meyer-Hoffert U; Hultenby K; Schroeder JM; Caparon MG; Normark S; Henriques-Normark B; Hultgren SJ; Kline KA
Article: JOURNAL OF BACTERIOLOGY. 2013;195(19):4484-4495
Pilin and Sortase Residues Critical for Endocarditis- and BiofilmAssociated Pilus Biogenesis in Enterococcus faecalis
Nielsen HV; Flores-Mireles AL; Kau AL; Kline KA; Pinkner JS; Neiers F; Normark S; Henriques-Normark B; Caparon MG; Hultgren SJ
Article: CELLULAR MICROBIOLOGY. 2013;15(8):1385-1400
Influenza A virus-mediated priming enhances cytokine secretion by human dendritic cells infected with Streptococcus pneumoniae
Kuri T; Sorensen AS; Thomas S; Hedestam GBK; Normark S; Henriques-Normark B; McInerney GM; Plant L
Article: PLOS GENETICS. 2013;9(10):e1003868
Dominant Role of Nucleotide Substitution in the Diversification of Serotype 3 Pneumococci over Decades and during a Single Infection
Croucher NJ; Mitchell AM; Gould KA; Inverarity D; Barquist L; Feltwell T; Fookes MC; Harris SR; Dordel J; Salter SJ; Browall S; Zemlickova H; Parkhill J; Normark S; Henriques-Normark B; Hinds J; Mitchell TJ; Bentley SD
Article: MBIO. 2012;4(1):e00535-e00512
Pilus Adhesin RrgA Interacts with Complement Receptor 3, Thereby Affecting Macrophage Function and Systemic Pneumococcal Disease
Orrskog S; Rounioja S; Spadafina T; Gallotta M; Norman M; Hentrich K; Falker S; Ygberg-Eriksson S; Hasenberg M; Johansson B; Uotila LM; Gahmberg CG; Barocchi M; Gunzer M; Normark S; Henriques-Normark B
Article: MBIO. 2012;3(4):e00177-e00112
The Metal Ion-Dependent Adhesion Site Motif of the Enterococcus faecalis EbpA Pilin Mediates Pilus Function in Catheter-Associated Urinary Tract Infection
Nielsen HV; Guiton PS; Kline KA; Port GC; Pinkner JS; Neiers F; Normark S; Henriques-Normark B; Caparon MG; Hultgren SJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(14):11018-11029
LytA, Major Autolysin of Streptococcus pneumoniae, Requires Access to Nascent Peptidoglycan
Mellroth P; Daniels R; Eberhardt A; Ronnlund D; Blom H; Widengren J; Normark S; Henriques-Normark B
Article: PLOS ONE. 2011;6(12):e29316
Impaired Release of Antimicrobial Peptides into Nasal Fluid of Hyper-IgE and CVID Patients
Cederlund A; Olliver M; Rekha RS; Lindh M; Lindbom L; Normark S; Henriques-Normark B; Andersson J; Agerberth B; Bergman P
Article: PLOS ONE. 2011;6(10):e26442
A Method for Metagenomics of Helicobacter pylori from Archived Formalin-Fixed Gastric Biopsies Permitting Longitudinal Studies of Carcinogenic Risk
Zheng Z; Andersson AF; Ye W; Nyren O; Normark S; Engstrand L
Article: PLOS ONE. 2011;6(8):e24394
Studies on the Antibacterial Effects of Statins - In Vitro and In Vivo
Bergman P; Linde C; Putsep K; Pohanka A; Normark S; Henriques-Normark B; Andersson J; Bjorkhem-Bergman L
Article: MUCOSAL IMMUNOLOGY. 2011;4(3):325-334
Control of intestinal Nod2-mediated peptidoglycan recognition by epithelium-associated lymphocytes
Duerr CU; Salzman NH; Dupont A; Szabo A; Normark BH; Normark S; Locksley RM; Mellroth P; Hornef MW
Article: INFECTION AND IMMUNITY. 2011;79(2):571-580
Identification of a Family of Effectors Secreted by the Type III Secretion System That Are Conserved in Pathogenic Chlamydiae
Muschiol S; Boncompain G; Vromman F; Dehoux P; Normark S; Henriques-Normark B; Subtil A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(5):3300-3309
Disulfide Bond Formation and Cysteine Exclusion in Gram-positive Bacteria
Daniels R; Mellroth P; Bernsel A; Neiers F; Normark S; von Heijne G; Henriques-Normark B
Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;393(3):704-716
Two Crystal Structures of Pneumococcal Pilus Sortase C Provide Novel Insights into Catalysis and Substrate Specificity
Neiers F; Madhurantakam C; Falker S; Manzano C; Dessen A; Normark S; Henriques-Normark B; Achour A
Article: EMBO MOLECULAR MEDICINE. 2009;1(4):211-222
Streptococcus pneumoniae evades human dendritic cell surveillance by pneumolysin expression
Littmann M; Albiger B; Frentzen A; Normark S; Henriques-Normark B; Plant L
Article: PLOS ONE. 2009;4(6):e5885
A Changing Gastric Environment Leads to Adaptation of Lipopolysaccharide Variants in Helicobacter pylori Populations during Colonization
Skoglund A; Backhed HK; Nilsson C; Bjorkholm B; Normark S; Engstrand L
Article: ENVIRONMENTAL MICROBIOLOGY. 2009;11(6):1348-1357
High abundance of virulence gene homologues in marine bacteria
Persson OP; Pinhassi J; Riemann L; Marklund B-I; Rhen M; Normark S; Gonzalez JM; Hagstrom A
Article: BMC MICROBIOLOGY. 2009;9:75
Small molecule inhibitors of the Yersinia type III secretion system impair the development of Chlamydia after entry into host cells
Muschiol S; Normark S; Henriques-Normark B; Subtil A
Article: JOURNAL OF INFECTIOUS DISEASES. 2009;199(7):1032-1042
Pattern of Accessory Regions and Invasive Disease Potential in Streptococcus pneumoniae
Blomberg C; Dagerhamn J; Dahlberg S; Browall S; Fernebro J; Albiger B; Morfeldt E; Normark S; Henriques-Normark B
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2009;65(Pt 1):55-58
Cloning, expression, purification, crystallization and preliminary X-ray analysis of the pilus-associated sortase C from Streptococcus pneumoniae
Neiers F; Madhurantakam C; Falker S; Normark S; Henriques-Normark B; Achour A
Article: PLOS ONE. 2008;3(11):e3811
Lipopolysaccharide Diversity Evolving in Helicobacter pylori Communities through Genetic Modifications in Fucosyltransferases
Nilsson C; Skoglund A; Moran AP; Annuk H; Engstrand L; Normark S
Article: MOLECULAR MICROBIOLOGY. 2008;70(3):595-607
Sortase-mediated assembly and surface topology of adhesive pneumococcal pili
Falker S; Nelson AL; Morfeldt E; Jonas K; Hultenby K; Ries J; Melefors O; Normark S; Henriques-Normark B
Article: INFECTION AND IMMUNITY. 2008;76(8):3710-3716
The capsule sensitizes Streptococcus pneumoniae to α-defensins human neutrophil proteins 1 to 3
Beiter K; Wartha F; Hurwitz R; Normark S; Zychlinsky A; Henriques-Normark B
Article: FASEB JOURNAL. 2008;22(7):2427-2434
Identification of heparin/heparan sulfate interacting protein as a major broad-spectrum antimicrobial protein in lung and small intestine
Meyer-Hoffert U; Hornef M; Henriques-Normark B; Normark S; Andersson M; Putsep K
Journal article: CELL. 2008;133(4):574-576
Twin ushers guide pili across the bacterial outer membrane
Daniels R; Normark S
Article: BMC MICROBIOLOGY. 2008;8:65
The influence of in vitro fitness defects on pneumococcal ability to colonize and to cause invasive disease
Fernebro J; Blomberg C; Morfeldt E; Wolf-Watz H; Normark S; Normark BH
Article: MOLECULAR MICROBIOLOGY. 2007;66(2):329-340
RrgA is a pilus-associated adhesin in Streptococcus pneumoniae
Nelson AL; Ries J; Bagnoli F; Dahlberg S; Falker S; Rounioja S; Tschop J; Morfeldt E; Ferlenghi I; Hilleringmann M; Holden DW; Rappuoli R; Normark S; Barocchi MA; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(31):12907-12912
Clonal success of piliated penicillin nonsusceptible pneumococci
Sjoestroem K; Blomberg C; Fernebro J; Dagerhamn J; Morfeldt E; Barocchi MA; Browall S; Moschioni M; Andersson M; Henriques F; Albiger B; Rappuoli R; Normark S; Henriques-Normark B
Article: BMC MICROBIOLOGY. 2007;7:70
Roles of curli, cellulose and BapA in Salmonella biofilm morphology studied by atomic force microscopy
Jonas K; Tomenius H; Kader A; Normark S; Roemling U; Belova LM; Melefors O
Article: CELLULAR MICROBIOLOGY. 2007;9(5):1162-1171
Capsule and D-alanylated lipoteichoic acids protect Streptococcus pneumoniae against neutrophil extracellular traps
Wartha F; Beiter K; Albiger B; Fernebro J; Zychlinsky A; Normark S; Henriques-Normark B
Article: CELLULAR MICROBIOLOGY. 2007;9(3):633-644
Toll-like receptor 9 acts at an early stage in host defence against pneumococcal infection
Albiger B; Dahlberg S; Sandgren A; Wartha F; Beiter K; Katsuragi H; Akira S; Normark S; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(39):14566-14571
A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis
Muschiol S; Bailey L; Gylfe A; Sundin C; Hultenby K; Bergstrom S; Elofsson M; Wolf-Watz H; Normark S; Henriques-Normark B
Article: BMC MICROBIOLOGY. 2006;6:27
The Escherichia coli BarA-UvrY two-component system is a virulence determinant in the urinary tract
Tomenius H; Pernestig AK; Jonas K; Georgellis D; Möllby R; Normark S; Melefors Ö
Article: CURRENT BIOLOGY. 2006;16(4):401-407
An endonuclease allows Streptococcus pneumoniae to escape from neutrophil extracellular traps
Beiter K; Wartha F; Albiger B; Normark S; Zychlinsky A; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(8):2857-2862
A pneumococcal pilus influences virulence and host inflammatory responses
Barocchi MA; Rie J; Zogaj X; Hemsley C; Albiger B; Kanth A; Dahlberg S; Fernebro J; Moschioni M; Masignani V; Hultenby K; Taddei AR; Beiter K; Wartha F; von Euler A; Covacci A; Holden DW; Normark S; Rappuoli R; Henriques-Normark B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(8):2863-2868
An enzymatic ruler modulates Lewis antigen glycosylation of Helicobacter pylori LPS during persistent infection
Nilsson C; Skoglund A; Moran AP; Annuk H; Engstrand L; Normark S
Article: CELLULAR MICROBIOLOGY. 2005;7(11):1603-1615
Myeloid differentiation factor 88-dependent signalling controls bacterial growth during colonization and systemic pneumococcal disease in mice
Albiger B; Sandgren A; Katsuragi H; Meyer-Hoffert U; Beiter K; Wartha F; Hornef M; Normark S; Normark BH
Article: JOURNAL OF BACTERIOLOGY. 2005;187(21):7317-7324
Genetic and functional characterization of the Escherichia coli BarA-UvrY two-component system: Point mutations in the HAMP linker of the BarA sensor give a dominant-negative phenotype
Tomenius H; Pernestig AK; Méndez-Catalá CF; Georgellis D; Normark S; Melefors Ö
Journal article: SCIENCE. 2005;307(5713):1211-1212
Microbiology - A pathogen attacks while keeping up defense
Normark S; Nilsson C; Normark BH
Article: CELLULAR MICROBIOLOGY. 2005;7(1):147-155
Components of the peptidoglycan-recycling pathway modulate invasion and intracellular survival of Salmonella enterica serovar Typhimurium
Folkesson A; Eriksson S; Andersson M; Park JT; Normark S
Article: RESEARCH IN MICROBIOLOGY. 2004;155(7):535-542
Transcriptional analysis of the acid-inducible asr gene in enterobacteria
Seputiene V; Suziedelis K; Normark S; Melefors Ö; Suziedeliene E
Journal article: NATURE MEDICINE. 2004;10(8):780-781
Staphylococcal protein A inflames the lungs
Normark BH; Normark S; Norrby-Teglund A
Article: SCIENCE. 2004;305(5683):519-522
Functional adaptation of BabA, the H-pylori ABO blood group antigen binding adhesin
Aspholm-Hurtig M; Dailide G; Lahmann M; Kalia A; Ilver D; Roche N; Vikström S; Sjöström R; Lindén S; Bäckström A; Lundberg C; Arnqvist A; Mahdavi J; Nilsson UJ; Velapatiño B; Gilman RH; Gerhard M; Alarcon T; López-Brea M; Nakazawa T; Fox JG; Correa P; Dominguez-Bello MG; Perez-Perez GI; Blaser MJ; Normark S; Carlstedt I; Oscarson S; Teneberg S; Berg DE; Borén T
Article: VACCINE. 2004;22(11-12):1448-1456
Immunogenic properties of the Salmonella atypical fimbriae in BALB/c mice
Strindelius L; Folkesson A; Normark S; Sjöholm I
Article: JOURNAL OF INFECTIOUS DISEASES. 2004;189(2):328-338
Capsular expression in Streptococcus pneumoniae negatively affects spontaneous and antibiotic-induced lysis and contributes to antibiotic tolerance.
Fernebro J; Andersson I; Sublett J; Morfeldt E; Novak R; Tuomanen E; Normark S; Normark BH
Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2004;38(1):3-14
Receptors for Escherichia coli adhesins in the genitourinary tract in a non-human primate
Ishikawa K; Sundelin B; Möllby R; Normark S; Winberg J
Article: INFECTION AND IMMUNITY. 2003;71(11):6573-6581
Correlation between cag pathogenicity island composition and Helicobacter pylori-associated gastroduodenal disease
Nilsson C; Sillén A; Eriksson L; Strand ML; Enroth H; Normark S; Falk P; Engstrand L
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2003;198(8):1225-1235
Intracellular recognition of lipopolysaccharide by Toll-like receptor 4 in intestinal epithelial cells
Hornef MW; Normark BH; Vandewalle A; Normark S
Article: MICROBES AND INFECTION. 2003;5(12):1057-1063
Structural requirements for TLR4-mediated LPS signalling:: a biological role for LPS modifications
Bäckhed F; Normark S; Schweda EKH; Oscarson S; Richter-Dahlfors A
Article: JOURNAL OF BACTERIOLOGY. 2003;185(8):2475-2484
Molecular characterization of the acid-inducible asr gene of Escherichia coli and its role in acid stress response
Seputiene V; Motiejunas D; Suziedelis K; Tomenius H; Normark S; Melefors O; Suziedeliene E
Article: JOURNAL OF BACTERIOLOGY. 2003;185(3):843-853
The Escherichia coli BarA-UvrY two-component system is needed for efficient switching between glycolytic and gluconeogenic carbon sources
Pernestig AK; Georgellis D; Romeo T; Suzuki K; Tomenius H; Normark S; Melefors Ö
Journal article: NATURE MEDICINE. 2002;8(12):1349-1350
Hosting for the cruel and the inconsequential
Normark BH; Normark S
Article: RESEARCH IN MICROBIOLOGY. 2002;153(8):537-545
The Salmonella enterica subspecies I specific centisome 7 genomic island encodes novel protein families present in bacteria living in close contact with eukaryotic cells
Folkesson A; Löfdahl S; Normark S
Article: CELLULAR MICROBIOLOGY. 2002;4(8):493-501
TLR4-dependent recognition of lipopolysaccharide by epithelial cells requires sCD14
Bäckhed F; Meijer L; Normark S; Richter-Dahlfors A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(13):8784-8789
Polynucleotide phosphorylase is a global regulator of virulence and persistency in Salmonella enterica
Clements MO; Eriksson S; Thompson A; Lucchini S; Hinton JCD; Normark S; Rhen M
Article: CELLULAR MICROBIOLOGY. 2002;4(5):297-303
TLR4-dependent lipopolysaccharide signalling in epithelial cells is independent of extracellular protease activity
Bäckhed F; Normark S; Richter-Dahlfors A
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2002;195(5):559-570
Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells
Hornef MW; Frisan T; Vandewalle A; Normark S; Richter-Dahlfors A
Journal article: NATURE IMMUNOLOGY. 2002;3(3):210-211
Gonococci cause immunosuppression by engaging a coinhibitory receptor on T lymphocytes
Normark S; Albiger B; Jonsson AB
Article: SCIENCE. 2002;295(5556):851-855
Role of Escherichia coli curli operons in directing amyloid fiber formation
Chapman MR; Robinson LS; Pinkner JS; Roth R; Heuser J; Hammar M; Normark S; Hultgren SJ
Journal article: NATURE MEDICINE. 2001;7(11):1182-1184
How neutrophils recognize bacteria and move toward infection
Normark S; Normark BH; Hornef M
Article: CELLULAR MICROBIOLOGY. 2001;3(3):153-158
Induction of innate immune responses by Escherichia coli and purified lipopolysaccharide correlate with organ- and cell-specific expression of Toll-like receptors within the human urinary tract
Bäckhed F; Söderhäll M; Ekman P; Normark S; Richter-Dahlfors A
Article: JOURNAL OF INFECTIOUS DISEASES. 2001;183(4):612-619
Activation of inducible nitric oxide synthase/nitric oxide by curli fibers leads to a fall in blood pressure during systemic Escherichia coli infection in mice
Bian Z; Yan ZQ; Hansson GK; Thorén P; Normark S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(51):40478-40482
Germ-free and colonized mice generate the same products from enteric prodefensins
Pütsep K; Axelsson LG; Boman A; Midtvedt T; Normark S; Boman HG; Andersson M
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(14):7670-7672
Anfinsen comes out of the cage during assembly of the bacterial pilus
Normark S
Article: NATURE. 2000;405(6787):694-697
α-Haemolysin of uropathogenic E-coli induces Ca²⁺ oscillations in renal epithelial cells
Uhlén P; Laestadius Å; Jahnukainen T; Söderblom T; Bäckhed F; Celsi G; Brismar H; Normark S; Aperia A; Richter-Dahlfors A
Article: MOLECULAR MICROBIOLOGY. 2000;36(1):10-23
AgfD, the checkpoint of multicellular and aggregative behaviour in Salmonella typhimurium regulates at least two independent pathways
Römling U; Rohde M; Olsén A; Normark S; Reinköster J
Article: JOURNAL OF INFECTIOUS DISEASES. 2000;181(2):774-778
Vaccination with FimH adhesin protects cynomolgus monkeys from colonization and infection by uropathogenic Escherichia coli
Langermann S; Möllby R; Burlein JE; Palaszynski SR; Auguste CG; DeFusco A; Strouse R; Schenerman MA; Hultgren SJ; Pinkner JS; Winberg J; Guldevall L; Söderhäll M; Ishikawa K; Normark S; Koenig S
Article: JOURNAL OF INFECTIOUS DISEASES. 2000;181(2):602-612
Expression of and cytokine activation by Escherichia coli curli fibers in human sepsis
Bian Z; Brauner A; Li YH; Normark S
Article: GASTROENTEROLOGY. 1999;117(3):595-604
Signal transduction-mediated adherence and entry of Helicobacter pylori into cultured cells
Su B; Johansson S; Fällman M; Patarroyo M; Granström M; Normark S
Article: MOLECULAR MICROBIOLOGY. 1999;33(3):612-622
Multiple insertions of fimbrial operons correlate with the evolution of Salmonella serovars responsible for human disease
Folkesson A; Advani A; Sukupolvi S; Pfeifer JD; Normark S; Löfdahl S
Article: NATURE. 1999;399(6736):590-593
Emergence of vancomycin tolerance in Streptococcus pneumoniae
Novak R; Henriques B; Charpentier E; Normark S; Tuomanen E
Article: FEBS LETTERS. 1999;451(3):249-252
The origin of cecropins;: implications from synthetic peptides derived from ribosomal protein L1
Pütsep K; Normark S; Boman HG
Journal article: NATURE. 1999;398(6729):671-672
Antibacterial peptide from H-pylori
Pütsep K; Brändén CI; Boman HG; Normark S
Article: JOURNAL OF INFECTIOUS DISEASES. 1998;178(5):1379-1390
Type I Helicobacter pylori shows Lewis^b-independent adherence to gastric cells requiring de novo protein synthesis in both host and bacteria
Su B; Hellström PM; Rubio C; Çelik J; Granström M; Normark S
Article: MOLECULAR MICROBIOLOGY. 1998;28(2):249-264
Multicellular and aggregative behaviour of Salmonella typhimurium strains is controlled by mutations in the agfD promoter
Romling U; Sierralta WD; Eriksson K; Normark S
Article: JOURNAL OF BACTERIOLOGY. 1998;180(5):1215-1223
MppA, a periplasmic binding protein essential for import of the bacterial cell wall peptide L-alanyl-γ-D-glutamyl-meso-diaminopimelate
Park JT; Raychaudhuri D; Li HS; Normark S; Mengin-Lecreulx D
Article: INFECTION AND IMMUNITY. 1998;66(2):469-473
Transcellular passage of Neisseria gonorrhoeae involves pilus phase variation
Ilver D; Källström H; Normark S; Jonsson AB
Article: JOURNAL OF BACTERIOLOGY. 1998;180(3):722-731
Curli fibers are highly conserved between Salmonella typhimurium and Escherichia coli with respect to operon structure and regulation
Römling U; Bian Z; Hammar M; Sierralta WD; Normark S
Article: JOURNAL OF INFECTIOUS DISEASES. 1998;177(1):247-252
Virulence and colonization-associated properties of Helicobacter pylori isolated from children and adolescents
Çelik J; Su B; Tirén U; Finkel Y; Thoresson AC; Engstrand L; Sandstedt B; Bernander S; Normark S
Article: MOLECULAR MICROBIOLOGY. 1997;26(1):11-23
Availability of the fibre subunit CsgA and the nucleator protein CsgB during assembly of fibronectin-binding curli is limited by the intracellular concentration of the novel lipoprotein CsgG
Loferer H; Hammar M; Normark S
Article: EMBO JOURNAL. 1997;16(19):5827-5836
Nucleator function of CsgB for the assembly of adhesive surface organelles in Escherichia coli
Bian Z; Normark S
Article: JOURNAL OF UROLOGY. 1997;158(4):1610-1613
Epitopes of the P-fimbrial adhesin of E. coli cause different urinary tract infections.
Roberts JA; Kaack MB; Baskin G; Marklund BI; Normark S
Article: JOURNAL OF CLINICAL INVESTIGATION. 1997;100(2):364-372
Induction of protective immunity after Escherichia coli bladder infection in primates - Dependence of the globoside-specific P-fimbrial tip adhesin and its cognate receptor
Soderhall M; Normark S; Ishikawa K; Karlsson KA; Teneberg S; Winberg J; Mollby R
Article: MOLECULAR MICROBIOLOGY. 1997;25(1):11-25
PiIC of pathogenic Neisseria is associated with the bacterial cell surface
Rahman M; Kallstrom H; Normark S; Jonsson AB
Journal article: SCIENCE. 1997;276(5313):659
Common themes amid diversity
Normark S; WolfWatz H
Article: CELL. 1997;88(6):823-832
Cytosolic intermediates for cell wall biosynthesis and degradation control inducible beta-lactam resistance in gram-negative bacteria
Jacobs C; Frere JM; Normark S
Article: METHODS IN MOLECULAR MEDICINE. 1997;8:205-224
Methods for the Identification of H. pylori Host Receptors.
Borén T; Wadström T; Normark S; Gordon JI; Falk PG
Article: JOURNAL OF UROLOGY. 1997;157(1):346-350
Molecular evidence for pap-G specific adhesion of Escherichia coli to human renal cells
Soderhall M; Bergerheim US; Jacobson SH; Lundahl J; Mollby R; Normark S; Winberg J
Article: SCIENCE. 1996;273(5279):1234-1236
Induction of gene expression in Escherichia coli after pilus-mediated adherence
Zhang JP; Normark S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(13):6562-6566
Nucleator-dependent intercellular assembly of adhesive curli organelles in Escherichia coli
Hammar M; Bian Z; Normark S
Journal article: SCIENCE. 1996;271(5247):315-316
Cellular microbiology emerging
Cossart P; Boquet P; Normark S; Rappuoli R
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1995;182(6):1695-1702
THE PAPG-ADHESIN AT THE TIP OF P-FIMBRIAE PROVIDES ESCHERICHIA-COLI WITH A COMPETITIVE EDGE IN EXPERIMENTAL BLADDER INFECTIONS OF CYNOMOLGUS MONKEYS
WINBERG J; MOLLBY R; BERGSTROM J; KARLSSON KA; LEONARDSSON I; MILH MA; TENEBERG S; HASLAM D; MARKLUND BI; NORMARK S
Article: MOLECULAR MICROBIOLOGY. 1995;18(4):661-670
Expression of two csg operons is required for production of fibronectin- and Congo red-binding curli polymers in Escherichia coli K-12
Hammar M; Arnqvist A; Bian Z; Olsen A; Normark S
Article: MOLECULAR MICROBIOLOGY. 1995;18(4):661-670
Expression of two csg operons is required for production of fibronectin- and congo red-binding curli polymers in Escherichia coli K-12.
Hammar M; Arnqvist A; Bian Z; Olsén A; Normark S
Article: JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION. 1995;21(3):288-296
HUMAN-MILK K-CASEIN AND INHIBITION OF HELICOBACTER-PYLORI ADHESION TO HUMAN GASTRIC-MUCOSA
STROMQVIST M; FALK P; BERGSTROM S; HANSSON L; LONNERDAL B; NORMARK S; HERNELL O
Article: MICROBIOLOGY-SGM. 1995;141:2367-2377
PILUS BIOGENESIS GENE, PILC, OF NEISSERIA-GONARRHOEAE - PILC1 AND PILC2 ARE EACH PART OF A LARGER DUPLICATION OF THE GONOCOCCAL GENOME AND SHARE UPSTREAM AND DOWNSTREAM HOMOLOGOUS SEQUENCES WITH OPA AND PIL LOCI
JONSSON AB; RAHMAN M; NORMARK S
Article: MOLECULAR MICROBIOLOGY. 1995;15(3):553-559
AMPD, ESSENTIAL FOR BOTH BETA-LACTAMASE REGULATION AND CELL-WALL RECYCLING, IS A NOVEL CYTOSOLIC N-ACETYLMURAMYL-L-ALANINE AMIDASE
JACOBS C; JORIS B; JAMIN M; KLARSOV K; VANBEEUMEN J; MENGINLECREULX D; VANHEIJENOORT J; PARK JT; NORMARK S; FRERE JM
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Review: MOLECULAR MICROBIOLOGY. 2020;113(3):650-658
The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease
Iovino F; Nannapaneni P; Henriques-Normark B; Normark S
Review: CELLULAR MICROBIOLOGY. 2019;21(11):e13077
Emerging concepts in the pathogenesis of the Streptococcus pneumoniae: From nasopharyngeal colonizer to intracellular pathogen
Subramanian K; Henriques-Normark B; Normark S
Review: JOURNAL OF INTERNAL MEDICINE. 2019;285(6):635-652
Pathogenesis and prevention of risk of cardiovascular events in patients with pneumococcal community-acquired pneumonia
Feldman C; Normark S; Henriques-Normark B; Anderson R
Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2014;119(2):205-208
Bacterial vaccines and antibiotic resistance
Henriques-Normark B; Normark S
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1408-1414
Commensal pathogens, with a focus on Streptococcus pneumoniae, and interactions with the human host
Henriques-Normark B; Normark S
Meeting abstract: GENOME BIOLOGY. 2010;11:p42
Metagenomic study of Helicobacter pylori microdissected from archived formalin-fixed paraffin-embedded biopsy sections
Zheng Z; Andersson AF; Ye W; Nyren O; Normark S; Engstrand L
Review: CELL HOST & MICROBE. 2009;5(6):580-592
Bacterial Adhesins in Host-Microbe Interactions
Kline KA; Falker S; Dahlberg S; Normark S; Henriques-Normark B
Review: NATURE REVIEWS MICROBIOLOGY. 2008;6(11):827-837
The rise and fall of bacterial clones: Streptococcus pneumoniae
Henriques-Normark B; Blomberg C; Dagerhamn J; Battig P; Normark S
Review: CURRENT OPINION IN INFECTIOUS DISEASES. 2008;21(3):304-312
The function and biological role of toll-like receptors in infectious diseases: an update
Hornef MW; Henriques-Normark B; Normark S
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2008;197(6):888-896
Streptococcus pneumoniae contains 3 rlrA pilus variants that are clonally related
Moschioni M; Donati C; Muzzi A; Masignani V; Censini S; Hanage WP; Bishop CJ; Reis JN; Normark S; Henriques-Normark B; Covacci A; Rappuoli R; Barocchi MA
Review: JOURNAL OF INTERNAL MEDICINE. 2007;261(6):511-528
Role of the innate immune system in host defence against bacterial infections: focus on the Toll-like receptors
Albiger B; Dahlberg S; Henriques-Normark B; Normark S
Review: CURRENT OPINION IN MICROBIOLOGY. 2007;10(1):52-56
Neutrophil extracellular traps: casting the NET over pathogenesis
Wartha F; Beiter K; Normark S; Henriques-Normark B
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2005;192(5):791-800
Virulence in mice of pneumococcal clonal types with known invasive disease potential in humans.
Sandgren A; Albiger B; Orihuela CJ; Tuomanen E; Normark S; Henriques-Normark B
Review: CONTRIBUTIONS TO MICROBIOLOGY. 2005;12:67-89
Fimbriae, pili, flagella and bacterial virulence.
Jonson A-B; Normark S; Rhen M
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2003;187(5):829-836
Gastric mucosal recognition of Helicobacter pylori is independent of Toll-like receptor 4
Bäckhed F; Rokbi B; Torstensson E; Zhao Y; Nilsson C; Seguin D; Normark S; Buchan AMJ; Richter-Dahlfors A
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2003;90:63-89
Persistent infection with Helicobacter pylori and the development of gastric cancer
Normark S; Nilsson C; Normark BH; Hornef MW
Review: NATURE IMMUNOLOGY. 2002;3(11):1033-1040
Bacterial strategies for overcoming host innate and adaptive immune responses
Hornef MW; Wick MJ; Rhen M; Normark S
Review: CLINICAL MICROBIOLOGY AND INFECTION. 2002;8(10):613-622
Antibiotic tolerance in pneumococci
Normark BH; Normark S
Review: JOURNAL OF INTERNAL MEDICINE. 2002;252(2):91-106
Evolution and spread of antibiotic resistance
Normark BH; Normark S
Review: FLUORESCENT PROBES. 2002;31:133-159
Host-pathogen interactions:: Structure and function of pili
Barnhart MM; Schilling JD; Bäckhed F; Dahlfors AR; Normark S; Hultgren SJ
Published conference paper: JOURNAL OF INFECTIOUS DISEASES. 2001;184(7):861-869
Dynamics of penicillin-susceptible clones in invasive pneumococcal disease
Normark BH; Kalin M; Örtqvist Å; Åkerlund T; Liljequist BO; Hedlund J; Svenson SB; Zhou J; Spratt BG; Normark S; Källenius G
Published conference paper: CLINICAL INFECTIOUS DISEASES. 2001;32(4):552-558
Clinical isolates of Streptococcus pneumoniae that exhibit tolerance of vancomycin
Normark BH; Novak R; Örtqvist Å; Källenius G; Tuomanen E; Normark S
Editorial comment: CURRENT OPINION IN MICROBIOLOGY. 2000;3(1):13-15
Host microbe interactions: bacteria - Innate immune response: attack and counter-attack - Editorial overview
Isberg RR; Normark S
Meeting abstract: GASTROENTEROLOGY. 1998;114(4):A1092
Phosphotyrosine signaling is required for adherence of H-pylori to cultured gastric cells:: H-pylori interaction with gastric cells using Yersinia as a tool.
Su B; Patarroyo M; Granström M; Normark S
Review: CURRENT OPINION IN MICROBIOLOGY. 1998;1(1):75-81
Fimbriae-mediated host-pathogen cross-talk
Abraham SN; Jonsson AB; Normark S
Published conference paper: MICROBIAL DRUG RESISTANCE. 1995;1(2):111-114
beta-lactamase induction in gram-negative bacteria is intimately linked to peptidoglycan recycling
Normark S
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Professor, Senior, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2025-2025
Professor, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2020-2024

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