Simone Tambaro

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Artiklar

Journal article: MOLECULAR NEUROBIOLOGY. 2024;:1-31

Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research

Vassal M; Martins F; Monteiro B; Tambaro S; Martinez-Murillo R; Rebelo S
Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585

Signal peptide peptidase-like 2b modulates the amyloidogenic pathway and exhibits an Aβ-dependent expression in Alzheimer's disease

Maccioni R; Travisan C; Badman J; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schroeder B; Nilsson P; Tambaro S
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S13)

Cholinergic pathway modulation by age‐dependent amyloid‐beta pathology in an APP‐knock‐in AD mice model

Mitra S; Gera R; Tambaro S; Nilsson P; Linderoth B; Behbahani H; Darreh‐Shori T; Eriksdotter M
Journal article: IBRO NEUROSCIENCE REPORTS. 2023;15:s447

PRO-NEUROGENIC THERAPEUTIC APPROACHES BASED ON BRI2 MODULATION

Martins F; Chen G; Zhao H; Nilsson P; Tambaro S; Rebelo S
Article: ALZHEIMERS RESEARCH & THERAPY. 2023;15(1):137

Feasibility and therapeutical potential of local intracerebral encapsulated cell biodelivery of BDNF to App^NL-G-F knock-in Alzheimer mice

Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg LU; Darreh-Shori T; Behbahani H; Nilsson P; Eriksdotter M
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S1)

Characteristics of peripheral immune system in a novel AppNL‐G‐F knock‐in mouse model of Alzheimer’s disease

Gera R; Mitra S; Tambaro S; Nilsson P; Eriksdotter M
Journal article: ALZHEIMERS & DEMENTIA. 2023;19(S1)

Hippocampal BDNF encapsulated cell bio‐delivery improves spontaneous behavioral alternations in the Y‐maze test in AppNL‐G‐F mice.

Tambaro S; Mitra S; Gera R; Linderoth B; Wahlberg L; Behbahani H; Darreh‐Shori T; Nilsson P; Eriksdotter M
Article: BIOLOGY-BASEL. 2023;12(6):805

The Expression of the Endocannabinoid Receptors CB2 and GPR55 Is Highly Increased during the Progression of Alzheimer's Disease in App^NL-G-F Knock-In Mice

Medina-Vera D; Zhao H; Bereczki E; Rosell-Valle C; Shimozawa M; Chen G; de Fonseca FR; Nilsson P; Tambaro S
Article: MOLECULAR THERAPY. 2023;31(2):487-502

Intravenous treatment with a molecular chaperone designed against f3-amyloid toxicity improves Alzheimer?s disease pathology in mouse models

Manchanda S; Galan-Acosta L; Abelein A; Tambaro S; Chen G; Nilsson P; Johansson J
Article: BRAIN COMMUNICATIONS. 2022;5(1):fcad001

Translational potential of synaptic alterations in Alzheimer's disease patients and amyloid precursor protein knock-in mice

Medina-Vera D; Enache D; Tambaro S; Abuhashish E; Rosell-Valle C; Winblad B; de Fonseca FR; Bereczki E; Nilsson P
Journal article: ALZHEIMERS & DEMENTIA. 2022;17

A novel therapeutic approach to treat Alzheimer's disease: The brain‐specific signal peptide peptidase‐like 2b (SPPL2b)

Tambaro S; Riccardo M; Zerial S; Wagener A; Andrade‐Talavera Y; Fisahn A; Mentrup T; Schröder B; Nilsson P
Article: CELL RESEARCH. 2022;32(2):157-175

An App knock-in rat model for Alzheimer's disease exhibiting Aβ and tau pathologies, neuronal death and cognitive impairments

Pang K; Jiang R; Zhang W; Yang Z; Li L-L; Shimozawa M; Tambaro S; Mayer J; Zhang B; Li M; Wang J; Liu H; Yang A; Chen X; Liu J; Winblad B; Han H; Jiang T; Wang W; Nilsson P; Guo W; Lu B
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303

Autophagy Impairment in App Knock-in Alzheimer's Model Mice

Jiang R; Shimozawa M; Mayer J; Tambaro S; Kumar R; Abelein A; Winblad B; Bogdanovic N; Nilsson P
Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567

Impaired spike-gamma coupling of area CA3 fast-spiking interneurons as the earliest functional impairment in the App^NL-G-F mouse model of Alzheimer's disease

Arroyo-Garcia LE; Isla AG; Andrade-Talavera Y; Balleza-Tapia H; Loera-Valencia R; Alvarez-Jimenez L; Pizzirusso G; Tambaro S; Nilsson P; Fisahn A
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2020;105:103498

Recombinant BRICHOS chaperone domains delivered to mouse brain parenchyma by focused ultrasound and microbubbles are internalized by hippocampal and cortical neurons

Galan-Acosta L; Sierra C; Leppert A; Pouliopoulos AN; Kwon N; Noel RL; Tambaro S; Presto J; Nilsson P; Konofagou EE; Johansson J
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro

Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstal H; Fisahn A; Abelein A; Johansson J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615

Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice

Tambaro S; Galan-Acosta L; Leppert A; Chen G; Biverstal H; Presto J; Nilsson P; Johansson J
Article: JOURNAL OF ALZHEIMER'S DISEASE REPORTS. 2018;2(1):27-39

The Bri2 and Bri3 BRICHOS Domains Interact Differently with Aβ42 and Alzheimer Amyloid Plaques

Dolfe L; Tambaro S; Tigro H; Del Campo M; Hoozemans JJM; Wiehager B; Graff C; Winblad B; Ankarcrona M; Kaldmae M; Teunissen CE; Ronnback A; Johansson J; Presto J
Article: NATURE COMMUNICATIONS. 2017;8(1):2081

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state

Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstal H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
Article: BEHAVIOURAL PHARMACOLOGY. 2016;27(1):57-68

Withania somnifera (L.) Dunal root extract alleviates formalin-induced nociception in mice: involvement of the opioidergic system

Orru A; Casu MA; Tambaro S; Marchese G; Casu G; Ruiu S
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2014;56:1-9

The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake

Godar SC; Bortolato M; Castelli MP; Casti A; Casu A; Chen K; Ennas MG; Tambaro S; Shih JC
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2014;729:67-74

Evaluation of selective cannabinoid CB₁ and CB₂ receptor agonists in a mouse model of lipopolysaccharide-induced interstitial cystitis

Tambaro S; Casu MA; Mastinu A; Lazzari P
Article: NEUROPHARMACOLOGY. 2013;75:223-232

Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice

Bortolato M; Godar SC; Tambaro S; Li FG; Devoto P; Coba MP; Chen K; Shih JC
Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2013;110:137-144

NESS002ie: A new fluorinated thiol endopeptidase inhibitor with antinociceptive activity in an animal model of persistent pain

Tambaro S; Reali R; Volonterio A; Zanda M; Olimpieri F; Pinna GA; Lazzari P
Article: NEUROPHARMACOLOGY. 2013;70:268-277

Long-term CB₁ receptor blockade enhances vulnerability to anxiogenic-like effects of cannabinoids

Tambaro S; Tomasi ML; Bortolato M
Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2013;62:256-269

Novel pyrazole derivatives as neutral CB₁ antagonists with significant activity towards food intake

Manca I; Mastinu A; Olimpieri F; Falzoi M; Sani M; Ruiu S; Loriga G; Volonterio A; Tambaro S; Bottazzi MEH; Zanda M; Pinna GA; Lazzari P
Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(4):542-551

Inhibition of 5α-reductase attenuates behavioral effects of D₁-, but not D₂-like receptor agonists in C57BL/6 mice

Frau R; Pillolla G; Bini V; Tambaro S; Devoto P; Bortolato M
Article: CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY. 2012;12(4):254-276

Synthesis and pharmacological evaluation of novel 4-alkyl-5-thien-2'-yl pyrazole carboxamides.

Lazzari P; Pau A; Tambaro S; Asproni B; Ruiu S; Pinna G; Mastinu A; Curzu MM; Reali R; Bottazzi MEH; Pinna GA; Murineddu G
Journal article: PHARMACEUTICALS. 2010;3(9):2799-2820

Vulnerability Factors for the Psychiatric and Behavioral Effects of Cannabis.

Bortolato M; Bini V; Tambaro S
Journal article: CHEMINFORM. 2010;41(1):no

ChemInform Abstract: Synthesis and Enzymatic Evaluation of Novel Partially Fluorinated Thiol Dual ACE/NEP Inhibitors.

Olimpieri F; Tambaro S; Fustero S; Lazzari P; Sanchez‐Rosello M; Pani L; Volonterio A; Zanda M
Article: NEUROBIOLOGY OF DISEASE. 2010;37(1):177-185

1-(2′,4′-dichlorophenyl)-6-methyl-N-cyclohexylamine-1,4-dihydroindeno[1,2-c]pyrazole-3-carboxamide, a novel CB2 agonist, alleviates neuropathic pain through functional microglial changes in mice

Luongo L; Palazzo E; Tambaro S; Giordano C; Gatta L; Scafuro MA; Rossi FS; Lazzari P; Pani L; de Novellis V; Malcangio M; Maione S
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2009;19(16):4715-4719

Synthesis and enzymatic evaluation of novel partially fluorinated thiol dual ACE/NEP inhibitors

Olimpieri F; Tambaro S; Fustero S; Lazzari P; Sanchez-Rosello M; Pani L; Volonterio A; Zanda M
Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2005;525(1-3):150-153

Modulation of ATP-mediated contractions of the rat vas deferens through presynaptic cannabinoid receptors

Tambaro S; Mongeau R; Dessi C; Pani L; Ruiu S
Article: BRAIN RESEARCH. 2005;1048(1-2):41-47

Effect of Δ⁹-tetrahydrocannabinol on phosphorylated CREB in rat cerebellum:: An immunohistochemical study

Casu MA; Pisu C; Sanna A; Tambaro S; Spada GP; Mongeau R; Pani L
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2005;312(2):710-717

Evaluation of tamsulosin and alfuzosin activity in the rat vas deferens: Relevance to ejaculation delays

Tambaro S; Ruiu S; Dessi C; Mongeau R; Marchese G; Pani L
Article: BEHAVIOURAL BRAIN RESEARCH. 2004;149(1):9-16

Haloperidol versus risperidone on rat "early onset" vacuous chewing

Marchese G; Bartholini F; Casu MA; Ruiu S; Casti P; Congeddu E; Tambaro S; Pani L
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2003;306(1):363-370

Synthesis and characterization of NESS 0327:: A novel putative antagonist of the CB₁ cannabinoid receptor

Ruiu S; Pinna GA; Marchese G; Mussinu JM; Saba P; Tambaro S; Casti P; Vargiu R; Pani L
Article: BIOLOGICAL RHYTHM RESEARCH. 2002;33(2):213-222

Circadian rhythms of histatin 1, histatin 3, histatin 5, statherin and uric acid in whole human saliva secretion

Castagnola M; Cabras T; Denotti G; Fadda MB; Gambarini G; Lupi A; Manca I; Onnis G; Piras V; Soro V; Tambaro S; Messana I
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Preprint: BIORXIV. 2022

Signal Peptide Peptidase-Like 2b affects APP cleavage and exhibits a biphasic Aβ-mediated expression in Alzheimer’s disease

Maccioni R; Travisan C; Zerial S; Wagener A; Andrade-Talavera Y; Picciau F; Grassi C; Chen G; Lemoine L; Fisahn A; Jiang R; Fluhrer R; Mentrup T; Schröder B; Nilsson P; Tambaro S
Review: FRONTIERS IN PSYCHIATRY. 2022;13:866052

Immunomodulatory Role of CB2 Receptors in Emotional and Cognitive Disorders

Morcuende A; Salud Garcia-Gutierrez M; Tambaro S; Nieto E; Manzanares J; Femenia T
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2021;78(21-22):6807-6822

The role of the integral type II transmembrane protein BRI2 in health and disease

Martins F; Santos I; Silva OAB; Tambaro S; Rebelo S
Review: BIOLOGY-BASEL. 2021;10(6):542

Potential and Limits of Cannabinoids in Alzheimer's Disease Therapy

Abate G; Uberti D; Tambaro S
Review: LIFE SCIENCES. 2019;224:120-127

Cannabidiol: Recent advances and new insights for neuropsychiatric disorders treatment

Premoli M; Aria F; Bonini SA; Maccarinelli G; Gianoncelli A; Della Pina S; Tambaro S; Memo M; Mastinu A
Review: JOURNAL OF ETHNOPHARMACOLOGY. 2018;227:300-315

Cannabis sativa: A comprehensive ethnopharmacological review of a medicinal plant with a long history

Bonini SA; Premoli M; Tambaro S; Kumar A; Maccarinelli G; Memo M; Mastinu A
Review: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2018;36(2):/j/hmbci.2018.36.issue-2/

Cannabinoids in health and disease: pharmacological potential in metabolic syndrome and neuroinflammation

Mastinu A; Premoli M; Ferrari-Toninelli G; Tambaro S; Maccarinelli G; Memo M; Bonini SA
Meeting abstract: AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS. 2017;24(sup1):7-8

BRICHOS - an anti-amyloid chaperone: evaluation of blood-brain barrier permeability of Bri2 BRICHOS

Tambaro S; Galan-Acosta L; Leppert A; Presto J; Johansson J
Conference publication: PROTEIN SCIENCE. 2017;26:31-32

Bri2 BRICHOS molecular chaperone activity is decoupled from its ability to inhibit amyloid fibril formation

Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J
Book chapter: CANNABINOID MODULATION OF EMOTION, MEMORY, AND MOTIVATION. 2015;p. 409-442

Interactions of Cannabis and Amphetamine-Type Stimulants

Tambaro S; Bortolato M
Review: RECENT PATENTS ON CNS DRUG DISCOVERY. 2012;7(1):25-40

Cannabinoid-related agents in the treatment of anxiety disorders: current knowledge and future perspectives.

Tambaro S; Bortolato M
Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B252

The detection in human saliva of small peptides deriving from histatin-1 and histatin-3.

Cassiano M; Lupi A; Giardina B; Patamia M; Cassiano L; Tambaro S; Cordaro M; Onnis G; Manca I; Gambarini G; Messana I
Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B252

The concentration of defensin-1 in human saliva.

Fadda MB; Masana I; Sofn V; Tambaro S; Pirus V; Denotti G; Gamharmi G; Zuppi C; Patama M; Giardina B; Castagnola M; Lupi A

Forskningsbidrag

Unraveling the Therapeutic Potential of SPPL2b in Alzheimer's Disease

Alzhimer´s Association

1 July 2024 - 30 June 2027
BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s Disease

Fundação para a Ciência e Tecnologia

1 January 2022 - 31 December 2024

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