Simone Tambaro

Simone Tambaro

Senior Research Specialist
Visiting address: BioClinicum J10:30, Visionsgatan 4, 17164 Solna
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Nilsson, 171 77 Stockholm


  • My research is based on characterizing new target proteins involved in the
    biological bases of Alzheimer's disease. In particular, I am studying the AD
    pathophysiological role of the intramembrane signal peptide peptidase like 2b
    (SPPL2b). For this purpose, we use the new AD mouse model, the APP-knock-in
    mouse AppNL-G-F and the SPPL2b deficient mouse line. My research is also
    concerned with evaluating the role of the endocannabinoidergic system (ECS)
    in neurological-related disorders and the biological mechanisms by which ECS
    is involved in neurodegenerative diseases such as AD.
    These projects are financially supported by Alzheimer´s Association, Olle Engkvists Stiftelse, Gun &


  • Bertil Stohnes Stiftelse, * *Demensfonden, * *Lindhés Advokatbyrå
    Stiftelse, * *Åhlén-stiftelsen, Stiftelsen för Gamla Tjänarinnor


  • Project team members:

    Jack Badman

    Eileen Mac Sweeney

    Sandra Perez Garcia



All other publications


  • Unraveling the Therapeutic Potential of SPPL2b in Alzheimer's Disease
    Alzhimer´s Association
    1 July 2024 - 30 June 2027
  • BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s Disease
    Fundação para a Ciência e Tecnologia
    1 January 2022 - 31 December 2024

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