Simone Tambaro

Simone Tambaro

Senior Research Specialist
Visiting address: BioClinicum J10:30, Visionsgatan 4, 17164 Solna
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Nilsson, 171 77 Stockholm
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About me

  • I have several years of experience in neuroscience and pharmacological research. After completing my bachelor’s degree in 2001, I began my research career at Neuroscience Scarl, Cagliari University, Italy. I then pursued a Ph.D. in Neuroscience at the University of Cagliari (2007-2010), followed by a postdoctoral position at the University of Southern California, USA (2010-2012). In 2012, I was awarded a Marie Curie Postdoctoral Research Fellowship for the PET-BRAIN project, which I worked on until 2014. 

  • I have been working since 2014 and since 2022 in the position of Senior Research Specialist at the Division of Neurogeriatrics at Karolinska Institutet. 
  • I have established an independent research program focused on identifying new target proteins involved in the biological mechanisms of Alzheimer’s disease. 
  • Throughout my career, I have secured several national grants (including those from Olle Engkvists Stiftelse, Alzheimerfonden, Demensfonden, and Åhlén-Stiftelsen) as well as international grants from organizations such as the Alzheimer’s Association.

Research

  • My research is based on characterizing new target proteins involved in the 

  • biological bases of Alzheimer's disease. In particular, I am studying the AD
    pathophysiological role of the intramembrane signal peptide peptidase like 2b (SPPL2b). For this purpose, we use the new AD mouse model, the APP-knock-in mouse AppNL-G-F and the SPPL2b deficient mouse line. My research is also concerned with evaluating the role of the endocannabinoidergic system (ECS) in neurological-related disorders and the biological mechanisms by which ECS is involved in neurodegenerative diseases such as AD.


    Funding: 

  •  

  • Alzheimer´s Association, Olle Engkvists Stiftelse, Gun &

  • Bertil Stohnes Stiftelse, Demensfonden, Lindhés Advokatbyrå Stiftelse, Åhlén-stiftelsen, Stiftelsen för Gamla Tjänarinnor

     

  • Project team members:

     

  • Jack Badman

    Eileen Mac Sweeney

    Bjorn Bakker

    Wenjun Li

     

Articles

All other publications

Grants

  • Unraveling the Therapeutic Potential of SPPL2b in Alzheimer's Disease
    Alzhimer´s Association
    1 July 2024 - 30 June 2027
  • BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s Disease
    Fundação para a Ciência e Tecnologia
    1 January 2022 - 31 December 2025

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