Simone Tambaro
Senior Research Specialist
E-mail: simone.tambaro@ki.se
Visiting address: BioClinicum J10:30, Visionsgatan 4, 17164 Solna
Postal address: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Nilsson, 171 77 Stockholm
About me
I have several years of experience in neuroscience and pharmacological research. After completing my bachelor’s degree in 2001, I began my research career at Neuroscience Scarl, Cagliari University, Italy. I then pursued a Ph.D. in Neuroscience at the University of Cagliari (2007-2010), followed by a postdoctoral position at the University of Southern California, USA (2010-2012). In 2012, I was awarded a Marie Curie Postdoctoral Research Fellowship for the PET-BRAIN project, which I worked on until 2014.
- I have been working since 2014 and since 2022 in the position of Senior Research Specialist at the Division of Neurogeriatrics at Karolinska Institutet.
- I have established an independent research program focused on identifying new target proteins involved in the biological mechanisms of Alzheimer’s disease.
- Throughout my career, I have secured several national grants (including those from Olle Engkvists Stiftelse, Alzheimerfonden, Demensfonden, and Åhlén-Stiftelsen) as well as international grants from organizations such as the Alzheimer’s Association.
Research
My research is based on characterizing new target proteins involved in the
- biological bases of Alzheimer's disease. In particular, I am studying the AD
pathophysiological role of the intramembrane signal peptide peptidase like 2b (SPPL2b). For this purpose, we use the new AD mouse model, the APP-knock-in mouse AppNL-G-F and the SPPL2b deficient mouse line. My research is also concerned with evaluating the role of the endocannabinoidergic system (ECS) in neurological-related disorders and the biological mechanisms by which ECS is involved in neurodegenerative diseases such as AD.
Funding: Alzheimer´s Association, Olle Engkvists Stiftelse, Gun &
- Bertil Stohnes Stiftelse, Demensfonden, Lindhés Advokatbyrå Stiftelse, Åhlén-stiftelsen, Stiftelsen för Gamla Tjänarinnor
Project team members:
Jack Badman
Eileen Mac Sweeney
Bjorn Bakker
Wenjun Li
Articles
- Journal article: MOLECULAR NEUROBIOLOGY. 2024;:1-31
- Article: PROGRESS IN NEUROBIOLOGY. 2024;235:102585
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S13)
- Journal article: IBRO NEUROSCIENCE REPORTS. 2023;15:s447
- Article: ALZHEIMER'S RESEARCH AND THERAPY. 2023;15(1):137
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S1)
- Journal article: ALZHEIMER'S AND DEMENTIA. 2023;19(S1)
- Article: MOLECULAR THERAPY. 2023;31(2):487-502
- Article: BRAIN COMMUNICATIONS. 2022;5(1):fcad001
- Article: CELL RESEARCH. 2022;32(2):157-175
- Journal article: ALZHEIMER'S AND DEMENTIA. 2022;17
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:878303
- Article: MOLECULAR PSYCHIATRY. 2021;26(10):5557-5567
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2020;105:103498
- Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615
- Article: JOURNAL OF ALZHEIMER'S DISEASE REPORTS. 2018;2(1):27-39
- Article: NATURE COMMUNICATIONS. 2017;8(1):2081
- Article: BEHAVIOURAL PHARMACOLOGY. 2016;27(1):57-68
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2014;56:1-9
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2014;729:67-74
- Article: NEUROPHARMACOLOGY. 2013;75:223-232
- Article: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR. 2013;110:137-144
- Article: NEUROPHARMACOLOGY. 2013;70:268-277
- Article: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 2013;62:256-269
- Article: PSYCHONEUROENDOCRINOLOGY. 2013;38(4):542-551
- Article: CENTRAL NERVOUS SYSTEM AGENTS IN MEDICINAL CHEMISTRY. 2012;12(4):254-276
- Journal article: PHARMACEUTICALS. 2010;3(9):2799-2820
- Journal article: CHEMINFORM. 2010;41(1):no
- Article: NEUROBIOLOGY OF DISEASE. 2010;37(1):177-185
- Article: BIOORGANIC AND MEDICINAL CHEMISTRY LETTERS. 2009;19(16):4715-4719
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2005;525(1-3):150-153
- Article: BRAIN RESEARCH. 2005;1048(1-2):41-47
- Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2005;312(2):710-717
- Article: BEHAVIOURAL BRAIN RESEARCH. 2004;149(1):9-16
- Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2003;306(1):363-370
- Article: BIOLOGICAL RHYTHM RESEARCH. 2002;33(2):213-222
- Show more
All other publications
- Book chapter: ANANDAMIDE IN HEALTH AND DISEASE. 2025;p. 419-443
- Review: FRONTIERS IN PSYCHIATRY. 2022;13:866052
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2021;78(21-22):6807-6822
- Review: BIOLOGY. 2021;10(6):542
- Review: LIFE SCIENCES. 2019;224:120-127
- Review: JOURNAL OF ETHNOPHARMACOLOGY. 2018;227:300-315
- Review: HORMONE MOLECULAR BIOLOGY AND CLINICAL INVESTIGATION. 2018;36(2):/j/hmbci.2018.36.issue-2/
- Meeting abstract: AMYLOID : THE INTERNATIONAL JOURNAL OF EXPERIMENTAL AND CLINICAL INVESTIGATION : THE OFFICIAL JOURNAL OF THE INTERNATIONAL SOCIETY OF AMYLOIDOSIS. 2017;24(sup1):7-8
- Conference publication: PROTEIN SCIENCE. 2017;26:31-32
- Book chapter: CANNABINOID MODULATION OF EMOTION, MEMORY, AND MOTIVATION. 2015;p. 409-442
- Review: RECENT PATENTS ON CNS DRUG DISCOVERY. 2012;7(1):25-40
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B252
- Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B252
Grants
- Unraveling the Therapeutic Potential of SPPL2b in Alzheimer's DiseaseAlzhimer´s Association1 July 2024 - 30 June 2027
- BRI2 role in neuronal differentiation and the underlying molecular mechanisms: towards an innovative regenerative therapy for Alzheimer’s DiseaseFundação para a Ciência e Tecnologia1 January 2022 - 31 December 2024