Randall S. Johnson

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Om mig

Randall S. Johnson är professor i molekylär biologi och hypoxins biologi vid institutionen för cell- och molekylärbiologi. Hypoxi är en medicinsk term som betyder att kroppens vävnader lider av syrebrist. Cancertumörer klarar sig vanligen med mindre syre än frisk vävnad och Randall S Johnssons forskning handlar om olika aspekter av detta.

Artiklar

Journal article: ELIFE. 2024;12
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: ELIFE. 2024;12:rp92707
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1293723
The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
Bargiela D; Cunha PP; Velica P; Krause LCM; Brice M; Barbieri L; Gojkovic M; Foskolou IP; Rundqvist H; Johnson RS
Journal article: FRONTIERS IN IMMUNOLOGY. 2024;15:1293723
The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy.
Bargiela D; Cunha PP; Veliça P; Krause LCM; Brice M; Barbieri L; Gojkovic M; Foskolou IP; Rundqvist H; Johnson RS
Article: NATURE METABOLISM. 2023;5(11):1840-1843
A century of the Warburg effect
Thompson CB; Vousden KH; Johnson RS; Koppenol WH; Sies H; Lu Z; Finley LWS; Frezza C; Kim J; Hu Z; Bartman CR
Article: NATURE METABOLISM. 2023;5(10):1747-1764
Glutarate regulates T cell metabolism and anti-tumour immunity
Minogue E; Cunha PP; Wadsworth BJ; Grice GL; Sah-Teli SK; Hughes R; Bargiela D; Quaranta A; Zurita J; Antrobus R; Velica P; Barbieri L; Wheelock CE; Koivunen P; Nathan JA; Foskolou IP; Johnson RS
Article: CELL REPORTS. 2023;42(9):113013
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou IP; Cunha PP; Sanchez-Lopez E; Minogue EA; Nicolet BP; Guislain A; Jorgensen C; Kostidis S; Zandhuis ND; Barbieri L; Bargiela D; Nathanael D; Tyrakis PA; Palazon A; Giera M; Wolkers MC; Johnson RS
Article: ELIFE. 2023;12:e84280
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha PP; Minogue E; Krause LCM; Hess RM; Bargiela D; Wadsworth BJ; Barbieri L; Brombach C; Foskolou IP; Bogeski I; Velica P; Johnson RS
Article: CANCER IMMUNOLOGY RESEARCH. 2023;11(3):351-363
Infiltration of Tumors Is Regulated by T cell-Intrinsic Nitric Oxide Synthesis
Cunha PP; Bargiela D; Minogue E; Krause LCM; Barbieri L; Brombach C; Gojkovic M; Marklund E; Pietsch S; Foskolou I; Branco CM; Veli P; Johnson RS
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1101433
Lactate exposure shapes the metabolic and transcriptomic profile of CD8+T cells
Barbieri L; Velica P; Gameiro PA; Cunha PP; Foskolou IP; Rullman E; Bargiela D; Johnson RS; Rundqvist H
Article: CELLS. 2022;11(16):2469
Hyperoxia Reprogrammes Microvascular Endothelial Cell Response to Hypoxia in an Organ-Specific Manner
Reiterer M; Eakin A; Johnson RS; Branco CM
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:837669
Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses
Bargiela D; Cunha PP; Velica P; Foskolou IP; Barbieri L; Rundqvist H; Johnson RS
Article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2021;9(1):28
Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
Lambden S; Cowburn AS; Macias D; Garrud TAC; Krause BJ; Giussani DA; Summers C; Johnson RS
Article: CIRCULATION RESEARCH. 2021;128(11):1694-1707
Perivascular Macrophages Regulate Blood Flow Following Tissue Damage
Vagesjo E; Parv K; Ahl D; Seignez C; Herrera Hidalgo C; Giraud A; Leite C; Korsgren O; Wallen H; Juusola G; Hakovirta HH; Rundqvist H; Essand M; Holm L; Johnson RS; Thalin C; Korpisalo P; Christoffersson G; Phillipson M
Article: CANCER IMMUNOLOGY RESEARCH. 2021;9(4):401-414
Modified Hypoxia-Inducible Factor Expression in CD8⁺ T Cells Increases Antitumor Efficacy
Velica P; Cunha PP; Vojnovic N; Foskolou IP; Bargiela D; Gojkovic M; Rundqvist H; Johnson RS
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2021;53(3):496-504
Inflammation Mediates Exercise Effects on Fatigue in Patients with Breast Cancer
Hiensch AE; Mijwel S; Bargiela D; Wengstrom Y; May AM; Rundqvist H
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:633586
Oxygen-Mediated Suppression of CD8+T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation
Gojkovic M; Cunha PP; Darmasaputra GS; Barbieri L; Rundqvist H; Velica P; Johnson RS
Article: ELIFE. 2020;9:e59996
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
Rundqvist H; Velica P; Barbieri L; Gameiro PA; Bargiela D; Gojkovic M; Mijwel S; Reitzner SM; Wulliman D; Ahlstedt E; Ule J; Ostman A; Johnson RS
Article: BLOOD ADVANCES. 2020;4(18):4483-4493
The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome
Foskolou IP; Barbieri L; Vernet A; Bargiela D; Cunha PP; Velica P; Suh E; Pietsch S; Matuleviciute R; Rundqvist H; McIntyre D; Smith KGC; Johnson RS
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):336
Cd8+ T-cell Depletion Abolishes The Anti-metastatic Effects Of Voluntary Running In A Mouse Model Of Breast Cancer
Rundqvist H; Barbieri L; Velica P; Mijwel S; Östman A; Johnson R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(26):15160-15171
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis
Jing C; Castro-Dopico T; Richoz N; Tuong ZK; Ferdinand JR; Lok LSC; Loudon KW; Banham GD; Mathews RJ; Cader Z; Fitzpatrick S; Bashant KR; Kaplan MJ; Kaser A; Johnson RS; Murphy MP; Siegel RM; Clatworthy MR
Article: ACTA PHYSIOLOGICA. 2020;229(2):e13461
Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE)
Gojkovic M; Darmasaputra GS; Velica P; Rundqvist H; Johnson RS
Journal article: ACCESS MICROBIOLOGY. 2020;2(2)
Metabolite X is a novel biomarker for sepsis diagnosis and treatment
Fitzpatrick S; Lambden S; Macias D; Puthucheary Z; Pietsch S; Mendil L; McPhil M; Johnson R
Article: FRONTIERS IN PHYSIOLOGY. 2020;11:147
2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
Fitzpatrick SF; Lambden S; Macias D; Puthucheary Z; Pietsch S; Mendil L; McPhail MJW; Johnson RS
Article: CELL STEM CELL. 2019;25(3):407-418.e6
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
Ho Y-H; del Toro R; Rivera-Torres J; Rak J; Korn C; Garcia-Garcia A; Macias D; Gonzalez-Gomez C; del Monte A; Wittner M; Waller AK; Foster HR; Lopez-Otin C; Johnson RS; Nerlov C; Ghevaert C; Vainchenker W; Louache F; Andres V; Mendez-Ferrer S
Article: SCIENTIFIC REPORTS. 2019;9(1):10246
Acute and chronic hypoxia differentially predispose lungs for metastases
Reiterer M; Colaco R; Emrouznejad P; Jensen A; Rundqvist H; Johnson RS; Branco C
Journal article: 2019
Lactate Potentiates Differentiation and Expansion of Cytotoxic T Cells
Rundqvist H; Velica P; Barbieri L; Gameiro P; Cunha PP; Gojkovic M; Bargiela D; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Perez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson RS
Article: TRANSPLANT INTERNATIONAL. 2019;32(1):95-106
Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study
Keraenen MAI; Raissadati A; Nykanen AI; Dashkevich A; Tuuminen R; Krebs R; Johnson RS; Syrjala SO; Lemstrom KB
Article: ELIFE. 2018;7:e34681
HIF-2α is essential for carotid body development and function
Macias D; Cowburn AS; Torres-Torrelo H; Ortega-Saenz P; Lopez-Barneo J; Johnson RS
Article: CELL METABOLISM. 2018;27(4):898-913.e7
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
Sim J; Cowburn AS; Palazon A; Madhu B; Tyrakis PA; Macias D; Bargiela DM; Pietsch S; Gralla M; Evans CE; Kittipassorn T; Chey YCJ; Branco CM; Rundqvist H; Peet DJ; Johnson RS
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1624
Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha
Fitzpatrick SF; Gojkovic M; Macias D; Tegnebratt T; Lu L; Samen E; Rundqvist H; Johnson RS
Article: CANCER CELL. 2017;32(5):669-683.e5
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A; Tyrakis PA; Macias D; Velica P; Rundqvist H; Fitzpatrick S; Vojnovic N; Phan AT; Loman N; Hedenfalk I; Hatschek T; Lovrot J; Foukakis T; Goldrath AW; Bergh J; Johnson RS
Article: ELIFE. 2017;6:e28755
Cardiovascular adaptation to hypoxia and the role of peripheral resistance
Cowburn AS; Macias D; Summers C; Chilvers ER; Johnson RS
Article: ACTA PHYSIOLOGICA. 2017;220(3):361-369
Cutaneous exposure to hypoxia does not affect skin perfusion in humans
Siebenmann C; Keramidas ME; Rundqvist H; Mijwel S; Cowburn AS; Johnson RS; Eiken O
Article: MOLECULAR AND CELLULAR BIOLOGY. 2017;37(13):e00630-e00616
A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase
Luecke-Johansson S; Gralla M; Rundqvist H; Ho JC; Johnson RS; Gradin K; Poellinger L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(24):6382-6387
Metabolic basis to Sherpa altitude adaptation
Horscroft JA; Kotwica AO; Laner V; West JA; Hennis PJ; Levett DZH; Howard DJ; Fernandez BO; Burgess SL; Ament Z; Gilbert-Kawai ET; Vercueil A; Landis BD; Mitchell K; Mythen MG; Branco C; Johnson RS; Feelisch M; Montgomery HE; Griffin JL; Grocott MPW; Gnaiger E; Martin DS; Murray AJ
Article: BIOLOGY OPEN. 2017;6(5):688-697
Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
Evans CE; Palazon A; Sim J; Tyrakis PA; Prodger A; Lu X; Chan S; Bendahl P-O; Belting M; Von Euler L; Rundqvist H; Johnson RS; Branco C
Article: SCIENCE IMMUNOLOGY. 2017;2(8):eaal2861
Hypoxia determines survival outcomes of bacterial infection through HIF-1α-dependent reprogramming of leukocyte metabolism
Thompson AAR; Dickinson RS; Murphy F; Thomson JP; Marriott HM; Tavares A; Willson J; Williams L; Lewis A; Mirchandani A; Coelho PDS; Doherty C; Ryan E; Watts E; Morton NM; Forbes S; Stimson RH; Hameed AG; Arnold N; Preston JA; Lawrie A; Finisguerra V; Mazzone M; Sadiku P; Goveia J; Taverna F; Carmeliet P; Foster SJ; Chilvers ER; Cowburn AS; Dockrell DH; Johnson RS; Meehan RR; Whyte MKB; Walmsley SR
Article: NEURON. 2016;92(6):1196-1203
A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium
Bleymehl K; Perez-Gomez A; Omura M; Moreno-Perez A; Macias D; Bai Z; Johnson RS; Leinders-Zufall T; Zufall F; Mombaerts P
Article: NATURE. 2016;540(7632):236-241
S-2-hydroxyglutarate regulates CD8⁺ T-lymphocyte fate
Tyrakis PA; Palazon A; Macias D; Lee KL; Phan AT; Velica P; You J; Chia GS; Sim J; Doedens A; Abelanet A; Evans CE; Griffiths JR; Poellinger L; Goldrath AW; Johnson RS
Article: IMMUNITY. 2016;45(5):1024-1037
Constitutive Glycolytic Metabolism Supports CD8⁺ T Cell Effector Memory Differentiation during Viral Infection
Phan AT; Doedens AL; Palazon A; Tyrakis PA; Cheung KP; Johnson RS; Goldrath AW
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(31):8801-8806
HIF2α-arginase axis is essential for the development of pulmonary hypertension
Cowburn AS; Crosby A; Macias D; Branco C; Colaco RDDR; Southwood M; Toshner M; Alexander LEC; Morrell NW; Chilvers ER; Johnson RS
Article: NATURE COMMUNICATIONS. 2016;7:11635
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Semba H; Takeda N; Isagawa T; Sugiura Y; Honda K; Wake M; Miyazawa H; Yamaguchi Y; Miura M; Jenkins DMR; Choi H; Kim J-W; Asagiri M; Cowburn AS; Abe H; Soma K; Koyama K; Katoh M; Sayama K; Goda N; Johnson RS; Manabe I; Nagai R; Komuro I
Article: BLOOD. 2016;127(10):1355-1360
Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation
Evans CE; Bendahl P-O; Belting M; Branco C; Johnson RS
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2016;4:99
Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior
Yamamoto H; Rundqvist H; Branco C; Johnson RS
Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3)
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells (vol 107, djv209, 2015)
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: BMC BIOLOGY. 2015;13:110
Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism
Ashmore T; Roberts LD; Morash AJ; Kotwica AO; Finnerty J; West JA; Murfitt SA; Fernandez BO; Branco C; Cowburn AS; Clarke K; Johnson RS; Feelisch M; Griffin JL; Murray AJ
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2015;93(8):891-904
Kidney injury is independent of endothelial HIF-1α
Kalucka J; Schley G; Georgescu A; Klanke B; Roessler S; Baumgartl J; Velden J; Amann K; Willam C; Johnson RS; Eckardt K-U; Weidemann A
Article: DEVELOPMENTAL CELL. 2015;33(5):507-521
HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes
Guimaraes-Camboa N; Stowe J; Aneas I; Sakabe N; Cattaneo P; Henderson L; Kilberg MS; Johnson RS; Chen J; McCulloch AD; Nobrega MA; Evans SM; Zambon AC
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(suppl_1)
Abstract 184: Pulmonary Microvascular Thrombosis Enhances Extravasation via Myeloid Hypoxia-Inducible Factors
Evans CE; Branco-Price C; Prodger A; Palazon A; Tyrakis P; Rundqvist H; Bendahl P-O; Belting M; Johnson RS
Article: NATURE COMMUNICATIONS. 2015;6:6340
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
Koh HS; Chang CY; Jeon S-B; Yoon HJ; Ahn Y-H; Kim H-S; Kim I-H; Jeon SH; Johnson RS; Park EJ
Article: FASEB JOURNAL. 2015;29(3):1102-1112
Suppression of erythropoiesis by dietary nitrate
Ashmore T; Fernandez BO; Evans CE; Huang Y; Branco-Price C; Griffin JL; Johnson RS; Feelisch M; Murray AJ
Journal article: JOURNAL OF HEPATOLOGY. 2015;:S0168-8278(15)00074-4
WITHDRAWN: Loss of hepatic HIF-1α accelerates lipid accumulation by inhibiting peroxisomal fatty acid oxidation in nonalcoholic fatty liver disease.
Arai T; Kato Y; Ishimoto K; Kanai M; Shinjo S; Sayama K; Suzuki T; Doi T; Johnson RS; Suematsu M; Goda N
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2014;592(21):4715-4731
Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart
Ashmore T; Fernandez BO; Branco-Price C; West JA; Cowburn AS; Heather LC; Griffin JL; Johnson RS; Feelisch M; Murray AJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(32):22459-22469
Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland
Paatero I; Seagroves TN; Vaparanta K; Han W; Jones FE; Johnson RS; Elenius K
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2014;307(3):r248-r255
Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism
Lindholm ME; Fischer H; Poellinger L; Johnson RS; Gustafsson T; Sundberg CJ; Rundqvist H
Article: DEVELOPMENTAL BIOLOGY. 2014;391(1):99-110
Gene-environment interaction demonstrates the vulnerability of the embryonic heart
O'Reilly VC; Floro KL; Shi H; Chapman BE; Preis JI; James AC; Chapman G; Harvey RP; Johnson RS; Grieve SM; Sparrow DB; Dunwoodie SL
Article: CELL. 2014;157(6):1339-1352
Increased Adipocyte O₂ Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity
Lee YS; Kim J-W; Osborne O; Oh DY; Sasik R; Schenk S; Chen A; Chung H; Murphy A; Watkins SM; Quehenberger O; Johnson RS; Olefsky JM
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(3):801-808
Epidermal Deletion of HIF-2α Stimulates Wound Closure
Cowburn AS; Alexander LEC; Southwood M; Nizet V; Chilvers ER; Johnson RS
Article: BLOOD. 2014;123(3):366-376
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
Thompson AAR; Elks PM; Marriott HM; Eamsamarng S; Higgins KR; Lewis A; Williams L; Parmar S; Shaw G; McGrath EE; Formenti F; Van Eeden FJ; Kinnula VL; Pugh CW; Sabroe I; Dockrell DH; Chilvers ER; Robbins PA; Percy MJ; Simon MC; Johnson RS; Renshaw SA; Whyte MKB; Walmsley SR
Article: ONCOTARGET. 2013;4(12):2567-2576
Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon
Branco-Price C; Evans CE; Johnson RS
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2013;2(6):e000548
Activation of Hypoxia-Inducible Factor-2 in Adipocytes Results in Pathological Cardiac Hypertrophy
Lin Q; Huang Y; Booth CJ; Haase VH; Johnson RS; Simon MC; Giordano FJ; Yun Z
Journal article: THORAX. 2013;68:a140
HYPOXIA INDUCES HYPOTHERMIA AND SICKNESS BEHAVIOUR IN MICE FOLLOWING SUBCUTANEOUS INJECTION OF LIVE STAPHYLOCOCCUS AUREUS
Thompson AAR; Marriott HM; Williams L; Shaw G; Hameed A; Parmar S; Preston JA; Simon MC; Johnson RS; Foster SJ; Dockrell DH; Whyte MK; Walmsley SR
Journal article: CANCER PREVENTION RESEARCH. 2013;6(11_Supplement):a65
Abstract A65: Effect of voluntary running on metastasis in a mouse model of breast cancer
Rundqvist H; Mijwel S; Ahlstedt E; Lindholm C; Strell C; Roswall P; Pietras K; Johnson R; Ostman A
Article: NATURE IMMUNOLOGY. 2013;14(11):1173-1182
Hypoxia-inducible factors enhance the effector responses of CD8⁺ T cells to persistent antigen
Doedens AL; Phan AT; Stradner MH; Fujimoto JK; Nguyen JV; Yang E; Johnson RS; Goldrath AW
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(43):17570-17575
HIF isoforms in the skin differentially regulate systemic arterial pressure
Cowburn AS; Takeda N; Boutin AT; Kim J-W; Sterling JC; Nakasaki M; Southwood M; Goldrath AW; Jamora C; Nizet V; Chilvers ER; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(41):16568-16573
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis
Miyauchi Y; Sato Y; Kobayashi T; Yoshida S; Mori T; Kanagawa H; Katsuyama E; Fujie A; Hao W; Miyamoto K; Tando T; Morioka H; Matsumoto M; Chambon P; Johnson RS; Kato S; Toyama Y; Miyamoto T
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2013;91(10):1199-1205
HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination
Bhandari T; Olson J; Johnson RS; Nizet V
Article: MICROCIRCULATION. 2013;20(5):385-393
Hypoxia-Inducible Factor-1 Is a Determinant of Lobular Structure and Oxygen Consumption in the Liver
Tsukada K; Tajima T; Hori S; Matsuura T; Johnson RS; Goda N; Suematsu M
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):407-414
Myeloid Hypoxia-Inducible Factor-1α Is Essential for Skeletal Muscle Regeneration in Mice
Scheerer N; Dehne N; Stockmann C; Swoboda S; Baba HA; Neugebauer A; Johnson RS; Fandrey J
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2013;91(5):637-644
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function
Alexander LEC; Akong-Moore K; Feldstein S; Johansson P; Anh N; McEachern EK; Nicatia S; Cowburn AS; Olson J; Cho JY; Isaacs HJ; Johnson RS; Broide DH; Nizet V
Journal article: ATMOSPHERIC RESEARCH. 2013;122:469-485
Smoke aerosol transport patterns over the Maritime Continent
Xian P; Reid JS; Atwood SA; Johnson RS; Hyer EJ; Westphal DL; Sessions W
Article: CELL STEM CELL. 2013;12(1):49-61
Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Takubo K; Nagamatsu G; Kobayashi CI; Nakamura-Ishizu A; Kobayashi H; Ikeda E; Goda N; Rahimi Y; Johnson RS; Soga T; Hirao A; Suematsu M; Suda T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(43):17478-17483
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function
Huang Y; Lei L; Liu D; Jovin I; Russell R; Johnson RS; Di Lorenzo A; Giordano FJ
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2012;90(9):1079-1089
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
Okumura CYM; Hollands A; Tran DN; Olson J; Dahesh S; von Koeckritz-Blickwede M; Thienphrapa W; Corle C; Jeung SN; Kotsakis A; Shalwitz RA; Johnson RS; Nizet V
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(35):14030-14034
microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation
Peng H; Kaplan N; Hamanaka RB; Katsnelson J; Blatt H; Yang W; Hao L; Bryar PJ; Johnson RS; Getsios S; Chandel NS; Lavker RM
Article: CANCER RESEARCH. 2012;72(13):3187-3195
Loss of Fibroblast HIF-1α Accelerates Tumorigenesis
Kim J-W; Evans C; Weidemann A; Takeda N; Lee YS; Stockmann C; Branco-Price C; Brandberg F; Leone G; Ostrowski MC; Johnson RS
Article: BLOOD. 2012;119(24):5931-5942
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
Meinecke A-K; Nagy N; Lago GD; Kirmse S; Klose R; Schroedter K; Zimmermann A; Helfrich I; Rundqvist H; Theegarten D; Anhenn O; Orian-Rousseau V; Johnson RS; Alitalo K; Fischer JW; Fandrey J; Stockmann C
Article: INTERNATIONAL JOURNAL OF HEMATOLOGY. 2012;95(5):471-477
HIF-mediated endothelial response during cancer progression
Evans CE; Branco-Price C; Johnson RS
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(5):1226-1236
Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration
Koehler T; Reizis B; Johnson RS; Weighardt H; Foerster I
Article: JOURNAL OF HEPATOLOGY. 2012;56(2):441-447
HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice
Nishiyama Y; Goda N; Kanai M; Niwa D; Osanai K; Yamamoto Y; Senoo-Matsuda N; Johnson RS; Miura S; Kabe Y; Suematsu M
Article: CANCER CELL. 2012;21(1):52-65
Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success
Branco-Price C; Zhang N; Schnelle M; Evans C; Katschinski DM; Liao D; Ellies L; Johnson RS
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;415(3):445-449
Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice
Ochiai D; Goda N; Hishiki T; Kanai M; Senoo-Matsuda N; Soga T; Johnson RS; Yoshimura Y; Suematsu M
Journal article: BLOOD. 2011;118(21):sci-38
Physiology of HIF Regulation of Erythropoiesis
Johnson RS
Article: JOURNAL OF CELL BIOLOGY. 2011;195(4):689-701
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye
Kurihara T; Westenskow PD; Krohne TU; Aguilar E; Johnson RS; Friedlander M
Article: DIABETOLOGIA. 2011;54(6):1554-1566
Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Muller cells
Lin M; Chen Y; Jin J; Hu Y; Zhou KK; Zhu M; Le Y-Z; Ge J; Johnson RS; Ma J-X
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(3):1053-1063
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Walmsley SR; Chilvers ER; Thompson AA; Vaughan K; Marriott HM; Parker LC; Shaw G; Parmar S; Schneider M; Sabroe I; Dockrell DH; Milo M; Taylor CT; Johnson RS; Pugh CW; Ratcliffe PJ; Maxwell PH; Carmeliet P; Whyte MKB
Article: NATURE CELL BIOLOGY. 2010;12(10):1007-1013
O₂ regulates stem cells through Wnt/β-catenin signalling
Mazumdar J; O'Brien WT; Johnson RS; LaManna JC; Chavez JC; Klein PS; Simon MC
Article: CANCER RESEARCH. 2010;70(19):7465-7475
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Doedens AL; Stockmann C; Rubinstein MP; Liao D; Zhang N; DeNardo DG; Coussens LM; Karin M; Goldrath AW; Johnson RS
Article: CELL STEM CELL. 2010;7(3):391-402
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
Takubo K; Goda N; Yamada W; Iriuchishima H; Ikeda E; Kubota Y; Shima H; Johnson RS; Hirao A; Suematsu M; Suda T
Article: GLIA. 2010;58(10):1177-1185
Astrocyte Hypoxic Response Is Essential for Pathological But Not Developmental Angiogenesis of the Retina
Weidemann A; Krohne TU; Aguilar E; Kurihara T; Takeda N; Dorrell MI; Simon MC; Haase VH; Friedlander M; Johnson RS
Article: PLOS ONE. 2010;5(7):e11863
Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature
Scott A; Powner MB; Gandhi P; Clarkin C; Gutmann DH; Johnson RS; Ferrara N; Fruttiger M
Article: CELL METABOLISM. 2010;11(5):364-378
The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
Zhang N; Fu Z; Linke S; Chicher J; Gorman JJ; Visk D; Haddad GG; Poellinger L; Peet DJ; Powell F; Johnson RS
Article: DEVELOPMENT. 2010;137(9):1563-1571
von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina
Kurihara T; Kubota Y; Ozawa Y; Takubo K; Noda K; Simon MC; Johnson RS; Suematsu M; Tsubota K; Ishida S; Goda N; Suda T; Okano H
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(5):2269-2282
VHL Deletion Impairs Mammary Alveologenesis but Is Not Sufficient for Mammary Tumorigenesis
Seagroves TN; Peacock DL; Liao D; Schwab LP; Krueger R; Handorf CR; Haase VH; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(9):4329-4334
Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis
Stockmann C; Kerdiles Y; Nomaksteinsky M; Weidemann A; Takeda N; Doedens A; Torres-Collado AX; Iruela-Arispe L; Nizet V; Johnson RS
Article: GENES & DEVELOPMENT. 2010;24(5):491-501
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
Takeda N; O'Dea EL; Doedens A; Kim J-W; Weidemann A; Stockmann C; Asagiri M; Simon MC; Hoffmann A; Johnson RS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(11):3373-3383
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice
Weidemann A; Kerdiles YM; Knaup KX; Rafie CA; Boutin AT; Stockmann C; Takeda N; Scadeng M; Shih AY; Haase VH; Simon MC; Kleinfeld D; Johnson RS
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;387(4):789-794
HIF-1α is necessary to support gluconeogenesis during liver regeneration
Tajima T; Goda N; Fujiki N; Hishiki T; Nishiyama Y; Senoo-Matsuda N; Shimazu M; Soga T; Yoshimura Y; Johnson RS; Suematsu M
Article: BLOOD. 2009;114(4):844-859
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
Fang H-Y; Hughes R; Murdoch C; Coffelt SB; Biswas SK; Harris AL; Johnson RS; Imityaz HZ; Simon MC; Fredlund E; Greten FR; Rius J; Lewis CE
Article: EXPERIMENTAL EYE RESEARCH. 2009;88(2):270-276
The function of VEGF-A in lens development: Formation of the hyaloid capillary network and protection against transient nuclear cataracts
Garcia CM; Shui Y-B; Kamath M; DeVillar J; Johnson RS; Gerber H-P; Ferrara N; Robinson ML; Beebe DC
Article: NATURE. 2008;456(7223):814-818
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
Stockmann C; Doedens A; Weidemann A; Zhang N; Takeda N; Greenberg JI; Cheresh DA; Johnson RS
Article: NATURE. 2008;456(7223):809-813
A role for VEGF as a negative regulator of pericyte function and vessel maturation
Greenberg JI; Shields DJ; Barillas SG; Acevedo LM; Murphy E; Huang J; Scheppke L; Stockmann C; Johnson RS; Angle N; Cheresh DA
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2008;49(11):4961-4970
HIF-1: An Age-Dependent Regulator of Lens Cell Proliferation
Shui Y-B; Arbeit JM; Johnson RS; Beebe DC
Article: ONCOGENE. 2008;27(40):5354-5358
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
Rankin EB; Rha J; Unger TL; Wu CH; Shutt HP; Johnson RS; Simon MC; Keith B; Haase VH
Article: DEVELOPMENT. 2008;135(17):2939-2948
Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis
Chen Y; Doughman Y-Q; Gu S; Jarrell A; Aota S-I; Cvekl A; Watanabe M; Dunwoodie SL; Johnson RS; van Heyningen V; Kleinjan DA; Beebe DC; Yang Y-C
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2008;128(8):1964-1968
Critical role of HIF-1α in keratinocyte defense against bacterial infection
Peyssonnaux C; Boutin AT; Zinkernagel AS; Datta V; Nizet V; Johnson RS
Article: NATURE. 2008;453(7196):807-811
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius J; Guma M; Schachtrup C; Akassoglou K; Zinkernagel AS; Nizet V; Johnson RS; Haddad GG; Karin M
Article: MOLECULAR AND CELLULAR BIOLOGY. 2008;28(11):3790-3803
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
Lei L; Mason S; Liu D; Huang Y; Marks C; Hickey R; Jovin IS; Pypaert M; Johnson RS; Giordano FJ
Article: CELL. 2008;133(2):223-234
Epidermal sensing of oxygen is essential for systemic hypoxic response
Boutin AT; Weidemann A; Fu Z; Mesropian L; Gradin K; Jamora C; Wiesener M; Eckardt K-U; Koch CJ; Ellies LG; Haddad G; Haase VH; Simon MC; Poellinger L; Powell FL; Johnson RS
Article: CANCER CELL. 2008;13(3):206-220
HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
Du R; Lu KV; Petritsch C; Liu P; Ganss R; Passegue E; Song H; VandenBerg S; Johnson RS; Werb Z; Bergers G
Journal article: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2008;27(2):s191
360: Constantly Stable HIF-1α in Myeloid Cells Prevents Acute Rejection in Rat Cardiac Allografts
Keränen MAI; Tuuminen R; Nykänen AI; Tavast E; Koskinen PK; Johnson RS; Lemström KB
Article: JOURNAL OF INFECTIOUS DISEASES. 2008;197(2):214-217
Pharmacologic augmentation of hypoxia-inducible factor-1α with mimosine boosts the bactericidal capacity of phagocytes
Zinkernagel AS; Peyssonnaux C; Johnson RS; Nizet V
Article: CELL CYCLE. 2008;7(1):28-32
Role of the hypoxia inducible factors in iron metabolism
Peyssonnaux C; Nizet V; Johnson RS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(12):3810-3820
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
Higgins DF; Kimura K; Bernhardt WM; Shrimanker N; Akai Y; Hohenstein B; Saito Y; Johnson RS; Kretzler M; Cohen CD; Eckardt K-U; Iwano M; Haase VH
Article: DEVELOPMENT. 2007;134(21):3917-3928
HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis
Amarilio R; Viukov SV; Sharir A; Eshkar-Oren I; Johnson RS; Zelzer E
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2007;293(5):r2059-r2069
HIF-1α in endurance training:: suppression of oxidative metabolism
Mason SD; Rundqvist H; Papandreou I; Duh R; McNulty WJ; Howlett RA; Olfert IM; Sundberg CJ; Denko NC; Poellinger L; Johnson RS
Article: BLOOD. 2007;110(8):3039-3048
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA-forming microsatellite
Bayele HK; Peyssonnaux C; Giatromanolaki A; Arrais-Silva WW; Mohamed HS; Collins H; Giorgio S; Koukourakis M; Johnson RS; Blackwell JM; Nizet V; Srai SKS
Article: ONCOGENE. 2007;26(31):4531-4540
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene
Blouw B; Haase VH; Song H; Bergers G; Johnson RS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(7):1926-1932
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Peyssonnaux C; Zinkernagel AS; Schuepbach RA; Rankin E; Vaulont S; Haase VH; Nizet V; Johnson RS
Article: JOURNAL OF IMMUNOLOGY. 2007;178(12):7516-7519
Cutting edge:: Essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis
Peyssonnaux C; Cejudo-Martin P; Doedens A; Zinkernagel AS; Johnson RS; Nizet V
Article: JOURNAL OF NEUROSCIENCE. 2007;27(23):6320-6332
Neuron-specific inactivation of the hypoxia inducible factor 1α increases brain injury in a mouse model of transient focal cerebral ischemia
Baranova O; Miranda LF; Pichiule P; Dragatsis I; Johnson RS; Chavez JC
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(6):1616-1626
The hypoxia-inducible factor a pathway couples angiogenesis to osteogenesis during skeletal development
Wang Y; Wan C; Deng L; Liu X; Cao X; Gilbert SR; Bouxsein ML; Faugere M-C; Guldberg RE; Gerstenfeld LC; Haase VH; Johnson RS; Schipani E; Clemens TL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(22):16187-16201
In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1α function regardless of the presence of DNA damage
Rempe DA; Lelli KM; Vangeison G; Johnson RS; Federoff HJ
Article: JOURNAL OF CELL BIOLOGY. 2007;177(3):451-464
Hif-1α regulates differentiation of limb bud mesenchyme and joint development
Provot S; Zinyk D; Gunes Y; Kathri R; Le Q; Kronenberg HM; Johnson RS; Longaker MT; Giaccia AJ; Schipani E
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(4):1068-1077
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
Rankin EB; Biju MP; Liu Q; Unger TL; Rha J; Johnson RS; Simon MC; Keith B; Haase VH
Article: MOLECULAR PHARMACOLOGY. 2007;71(3):942-948
ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1α (HIF-1α) binding and mediates HIF-1α expression by bafilomycin A1
Lim J-H; Park J-W; Kim SJ; Kim M-S; Park S-K; Johnson RS; Chun Y-S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(7):2301-2306
Acute postnatal ablation of Hif-2α results in anemia
Gruber M; Hu C-J; Johnson RS; Brown EJ; Keith B; Simon MC
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2007;30(2):341-348
von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase
Park S-K; Haase VH; Johnson RS
Article: CANCER RESEARCH. 2007;67(2):563-572
Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression
Liao D; Corle C; Seagroves TN; Johnson RS
Article: MOLECULAR PHARMACOLOGY. 2006;70(6):1856-1865
Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1α
Lim J-H; Park J-W; Kim M-S; Park S-K; Johnson RS; Chun Y-S
Article: TISSUE ENGINEERING. 2006;12(11):3135-3147
In vitro liver tissue model established from transgenic mice:: Role of HIF-1alpha on hypoxic gene expression
Allen JW; Khetani SR; Johnson RS; Bhatia SN
Journal article: TISSUE ENGINEERING. 2006;0(0):061004065151004
In Vitro Liver Tissue Model Established from Transgenic Mice: Role of HIF1alpha on Hypoxic Gene Expression
Allen JW; Khetani SR; Johnson RS; Bhatia SN
Article: NATURE MEDICINE. 2006;12(7):793-800
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Tam BYY; Wei K; Rudge JS; Hoffman J; Holash J; Park S-K; Yuan J; Hefner C; Chartier C; Lee J-S; Jiang S; Niyak NR; Kuypers FA; Ma L; Sundram U; Wu G; Garcia JA; Schrier SL; Maher JJ; Johnson RS; Yancopoulos GD; Mulligan RC; Kuo CJ
Article: BLOOD. 2006;107(9):3727-3732
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
Peyssonnaux C; Zinkernagel AS; Datta V; Lauth X; Johnson RS; Nizet V
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(7):2519-2530
pVHL function is essential for endothelial extracellular matrix deposition
Tang N; Mack F; Haase VH; Simon MC; Johnson RS
Article: CELLULAR MICROBIOLOGY. 2006;8(2):339-352
The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels
Spear W; Chan D; Coppens I; Johnson RS; Giaccia A; Blader IJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(47):17071-17076
Hypoxia inducible factor 1α regulates T cell receptor signal transduction
Neumann AK; Yang J; Biju MP; Joseph SK; Johnson RS; Haase VH; Freedman BD; Turka LA
Article: JOURNAL OF CLINICAL INVESTIGATION. 2005;115(7):1806-1815
HIF-1α expression regulates the bactericidal capacity of phagocytes
Peyssonnaux C; Datta V; Cramer T; Doedens A; Theodorakis EA; Gallo RL; Hurtado-Ziola N; Nizet V; Johnson RS
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(12):5040-5051
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation
Mialon A; Sankinen M; Söderström H; Junttila TT; Holmström T; Koivusalo R; Papageorgiou AC; Johnson RS; Hietanen S; Elenius K; Westermarck J
Article: JOURNAL OF NEUROSCIENCE. 2005;25(16):4099-4107
Brain-specific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxic-ischemic damage
Helton R; Cui J; Scheel JR; Ellison JA; Ames C; Gibson C; Blouw B; Ouyang L; Dragatsis I; Zeitlin S; Johnson RS; Lipton SA; Barlow C
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(8):3163-3172
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice
Rankin EB; Higgins DF; Walisser JA; Johnson RS; Bradfield CA; Haase VH
Article: JOURNAL OF CELL BIOLOGY. 2005;168(6):911-920
Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1
Xie L; Johnson RS; Freeman RS
Article: TOXICOLOGY LETTERS. 2005;155(1):151-159
Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1 alpha
Allen JW; Johnson RS; Bhatia SN
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(1):105-115
Hypoxia-induced neutrophil survival is mediated by HIF-1α-dependent NF-κB activity
Walmsley SR; Print C; Farahi N; Peyssonnaux C; Johnson RS; Cramer T; Sobolewski A; Condliffe AM; Cowburn AS; Johnson N; Chilvers ER
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2004;287(6):f1223-f1232
Hypoxic induction of Ctgf is directly mediated by Hif-1
Higgins DF; Biju MP; Akai Y; Wutz A; Johnson RS; Haase VH
Journal article: BLOOD. 2004;104(11):2163
Hypoxia-independent regulation of hepatic erythropoietin production by vascular endothelial growth factor.
Tam BYY; Hoffman J; Park SK; Lee JS; Sundram U; Wu G; Schrier SL; Johnson R; Mulligan R; Kuo CJ
Article: CANCER CELL. 2004;6(5):485-495
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
Tang N; Wang LC; Esko J; Giordano FJ; Huang Y; Gerber HP; Ferrara N; Johnson RS
Journal article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(8):1098-1106
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen J; Furuta GT; Tomaszewski JE; Johnson RS; Colgan SP; Haase VH
Article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(8):1098-1106
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen J; Furuta GT; Tomaszewski JE; Johnson RS; Colgan SP; Haase VH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(40):14461-14466
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
Ogawa S; Lozach J; Jepsen K; Sawka-Verhelle D; Perissi V; Sasik R; Rose DW; Johnson RS; Rosenfeld MG; Glass CK
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(20):9038-9047
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
Biju MP; Neumann AK; Bensinger SJ; Johnson RS; Turka LA; Haase VH
Article: PLOS BIOLOGY. 2004;2(10):e288-1548
Loss of skeletal muscle HIF-1α results in altered exercise endurance
Mason SD; Howlett RA; Kim MJ; Olfert IM; Hogan MC; McNulty W; Hickey RP; Wagner PD; Kahn CR; Giordano FJ; Johnson RS
Article: FASEB JOURNAL. 2004;18(7):1138-1140
Cardiac myocyte-specific HIF-1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart
Huang Y; Hickey RP; Yeh JL; Liu DG; Dadak A; Young LH; Johnson RS; Giordano FJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):23969-23976
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice
Galijatovic A; Beaton D; Nguyen N; Chen SJ; Bonzo J; Johnson R; Maeda S; Karin M; Guengerich FP; Tukey RH
Article: OSTEOARTHRITIS AND CARTILAGE. 2004;12(6):433-439
Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1α dependent
Cramer T; Schipani E; Johnson RS; Swoboda B; Pfander D
Article: DEVELOPMENT. 2004;131(10):2497-2508
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development
Pfander D; Kobayashi T; Knight MC; Zelzer E; Chan DA; Olsen BR; Giaccia AJ; Johnson RS; Haase VH; Schipani E
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(10):4128-4137
Glucose utilization is essential for hypoxia-inducible factor 1α-dependent phosphorylation of c-jun
Laderoute KR; Calaoagan JM; Knapp M; Johnson RS
Article: DEVELOPMENT. 2004;131(9):2161-2171
VEGFA is necessary for chondrocyte survival during bone development
Zelzer E; Mamluk R; Ferrara N; Johnson RS; Schipani E; Olsen BR
Article: CELL CYCLE. 2004;3(2):163-166
An unexpected role for hypoxic response - Oxygenation and inflammation
Peyssonnaux C; Johnson RS
Article: CANCER CELL. 2003;4(2):133-146
The hypoxic response of tumors is dependent on their microenvironment
Blouw B; Song HQ; Tihan T; Bosze J; Ferrara N; Gerber HP; Johnson RS; Bergers G
Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(14):4959-4971
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α):: Role of cytoplasmic trapping of HIF-2α
Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS
Article: DEVELOPMENTAL CELL. 2003;4(6):865-877
c-Jun is essential for organization of the epidermal leading edge
Li GC; Gustafson-Brown C; Hanks SK; Nason K; Arbeit JM; Pogliano K; Wisdom RM; Johnson RS
Article: CELL CYCLE. 2003;2(3):191-192
A Novel Role for the Hypoxia Inducible Transcription Factor HIF-1α Critical Regulation of Inflammatory Cell Function
Cramer T; Johnson RS
Article: ONCOGENE. 2003;22(21):3213-3220
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
Unruh A; Ressel A; Mohamed HG; Johnson RS; Nadrowitz R; Richter E; Katschinski DM; Wenger RH
Journal article: CELL. 2003;113(3):419
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(9):3265-3273
Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells
Mihaylova VT; Bindra RS; Yuan JL; Campisi D; Narayanan L; Jensen R; Giordano F; Johnson RS; Rockwell S; Glazer PM
Article: JOURNAL OF CELL SCIENCE. 2003;116(9):1819-1826
HIF-1α controls extracellular matrix synthesis by epiphyseal chondrocytes
Pfander D; Cramer T; Schipan E; Johnson RS
Article: DEVELOPMENT. 2003;130(8):1713-1724
HIF1α a is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland
Seagroves TN; Hadsell D; McManaman J; Palmer C; Liao D; McNulty W; Welm B; Wagner KU; Neville M; Johnson RS
Article: CELL. 2003;112(5):645-657
HIF-1α is essential for myeloid cell-mediated inflammation
Cramer T; Yamanishi Y; Clausen BE; Förster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS
Journal article: HEPATOLOGY. 2003;38:270
235 Oxygen modulation of cytochrome P450 pathways: role of oxygen gradients and HIF-1alpha in hepatocytes in vitro
Allen JW; Johnson RS; Bhatia SN
Article: GENE EXPRESSION. 2003;11(3-4):181-197
Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1α null mouse embryonic fibroblasts
Vengellur A; Woods BG; Ryan HE; Johnson RS; LaPres JJ
Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(1):359-369
Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia
Goda N; Ryan HE; Khadivi B; McNulty W; Rickert RC; Johnson RS
Article: DEVELOPMENTAL CELL. 2002;3(3):351-365
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
Putkey FR; Cramer T; Morphew MK; Silk AD; Johnson RS; McIntosh JR; Cleveland DW
Article: JOURNAL OF CELL BIOLOGY. 2002;158(3):453-461
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation
Palmada M; Kanwal S; Rutkoski NJ; Gufstafson-Brown C; Johnson RS; Wisdom R; Carter BD
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(8):2515-2523
The response of c-Jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1α dependent
Laderoute KR; Calaoagan JM; Gustafson-Brown C; Knapp AM; Li GC; Mendonca HL; Ryan HE; Wang ZH; Johnson RS
Article: DEVELOPMENTAL CELL. 2002;2(3):331-341
Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13:: A mechanism for regulation of adipogenesis by hypoxia
Yun Z; Maecker HL; Johnson RS; Giaccia AJ
Article: FASEB JOURNAL. 2002;16(1):411-413
Physiologically low oxygen concentrations determined in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor β3
Scheid A; Wenger RH; Schäffer L; Camenisch I; Distler O; Ferenc A; Cristina H; Ryan HE; Johnson RS; Wagner KF; Stauffer UG; Bauer C; Gassmann M; Meuli M
Article: CANCER JOURNAL. 2002;8(1):47-54
Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance
Gupta VK; Jaskowiak NT; Beckett MA; Mauceri HJ; Grunstein J; Johnson RS; Calvin DA; Nodzenski E; Pejovic M; Kufe DW; Posner MC; Weichselbaum RR
Article: CELL. 2001;107(6):763-775
IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
Cao YX; Bonizzi G; Seagroves TN; Greten FR; Johnson R; Schmidt EV; Karin M
Article: GENES & DEVELOPMENT. 2001;15(21):2865-2876
Hypoxia in cartilage:: HIF-1α is essential for chondrocyte growth arrest and survival
Schipani E; Ryan HE; Didrickson S; Kobayashi T; Knight M; Johnson RS
Article: GENES & DEVELOPMENT. 2001;15(19):2520-2532
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
Elson DA; Thurston G; Huang LE; Ginzinger DG; McDonald DM; Johnson RS; Arbeit JM
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;284(5):1134-1139
c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells
Laderoute KR; Calaoagan JM; Knapp AM; Mendonca HL; Johnson RS
Article: GENES & DEVELOPMENT. 2001;15(11):1435-1448
Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium
Mohanty S; Lee S; Yadava N; Dealy MJ; Johnson RS; Firtel RA
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(10):3436-3444
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
Seagroves TN; Ryan HE; Lu H; Wouters BG; Knapp M; Thibault P; Laderoute K; Johnson RS
Article: CANCER RESEARCH. 2000;60(21):6189-6195
Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
Elson DA; Ryan HE; Snow JW; Johnson R; Arbeit JM
Article: MOLECULAR AND CELLULAR BIOLOGY. 2000;20(19):7282-7291
Isoforms of vascular endothelial growth factor act in a coordinate fashion to recruit and expand tumor vasculature
Grunstein J; Masbad JJ; Hickey R; Giordano F; Johnson RS
Journal article: IMMUNOPHARMACOLOGY. 2000;49(1-2):80
Activation of the alternative complement pathway in factor D-deficient mice
Xu Y; Ma M; Ippolito GC; Johnson RS; Szalai AJ; Spiegelman BM; Schroeder HW; Carroll MC; Volanakis JE
Article: CANCER RESEARCH. 2000;60(15):4010-4015
Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
Ryan HE; Poloni M; McNulty W; Elson D; Gassmann M; Arbeit JM; Johnson RS
Article: CELL. 2000;102(2):221-231
Requirement for p38α in erythropoietin expression:: A role for stress kinases in erythropoiesis
Tamura K; Sudo T; Senftleben U; Dadak AM; Johnson R; Karin M
Journal article: MOLECULAR ENDOCRINOLOGY. 2000;14(6):848-862
Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis
Garayoa M
Article: MOLECULAR CELL. 2000;5(6):969-979
Female mice heterozygous for IKKγ/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
Makris C; Godfrey VL; Krähn-Senftleben G; Takahashi T; Roberts JL; Schwarz T; Feng LL; Johnson RS; Karin M
Article: MOLECULAR ENDOCRINOLOGY. 2000;14(6):848-862
Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: A possible promotion mechanism of carcinogenesis
Garayoa M; Martínez A; Lee SM; Pío R; An WG; Neckers L; Trepel J; Montuenga LM; Ryan H; Johnson R; Gassmann M; Cuttitta F
Article: GENES & DEVELOPMENT. 2000;14(4):391-396
Loss of PTEN facilitates HIF-1-mediated gene expression
Zundel W; Schindler C; Haas-Kogan D; Koong A; Kaper F; Chen E; Gottschalk AR; Ryan HE; Johnson RS; Jefferson AB; Stokoe D; Giaccia AJ
Article: IMMUNITY. 2000;12(1):17-26
Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
Rivera RR; Johns CP; Quan J; Johnson RS; Murre C
Journal article: CANCER RESEARCH. 2000;60(1):38-41
Carcinogenic nickel induces genes involved with hypoxic stress
Salnikow K; Blagosklonny MV; Ryan H; Johnson R; Costa M
Article: NATURE GENETICS. 1999;23(2):245-248
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
Dealy MJ; Nguyen KVT; Lo J; Gstaiger M; Krek W; Elson D; Arbeit J; Kipreos ET; Johnson RS
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1999;189(11):1839-1845
The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
Li ZW; Chu WM; Hu YL; Delhase M; Deerinck T; Ellisman M; Johnson R; Karin M
Article: SCIENCE. 1999;284(5412):316-320
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
Hu YL; Baud V; Delhase M; Zhang PL; Deerinck T; Ellisman M; Johnson R; Karin M
Journal article: CANCER RESEARCH. 1999;59(7):1592-1598
Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
Grunstein J; Roberts WG; Mathieu-Costello O; Hanahan D; Randall S
Article: EMBO JOURNAL. 1999;18(1):188-197
c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
Wisdom R; Johnson RS; Moore C
Article: EMBO JOURNAL. 1998;17(11):3005-3015
HIF-1α is required for solid tumor formation and embryonic vascularization
Ryan HE; Lo J; Johnson RS
Journal article: JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY. 1998;73(6):856-861
The effect of timing of post-harvest foliar urea sprays on nitrogen absorption and partitioning in peach and nectarine trees
Rosecrance RC; Johnson RS; Weinbaum SA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(25):14060-14065
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
Kash SF; Johnson RS; Tecott LH; Noebels JL; Mayfield RD; Hanahan D; Baekkeskov S
Article: SCIENCE. 1996;274(5291):1377-1379
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
Hotamisligil GS; Johnson RS; Distel RJ; Ellis R; Papaioannou VE; Spiegelman BM
Journal article: MOLECULAR AND CELLULAR BIOLOGY. 1996;16(8):4504-4511
Cellular transformation and malignancy induced by ras require c-jun
Johnson R; Spiegelman B; Hanahan D; Wisdom R
Article: JOURNAL OF NEUROSCIENCE. 1996;16(12):3827-3836
Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy
Watanabe Y; Johnson RS; Butler LS; Binder DK; Spiegelman BM; Papaioannou VE; McNamara JO
Article: JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY. 1996;178(4):563-570
The circadian system of c-fos deficient mice
Honrado GI; Johnson RS; Golombek DA; Spiegelman BM; Papaioannou VE; Ralph MR
Journal article: EMBO JOURNAL. 1995;14(10):2217-2228
A TRANSITION IN TRANSCRIPTIONAL ACTIVATION BY THE GLUCOCORTICOID AND RETINOIC ACID RECEPTORS AT THE TUMOR STAGE OF DERMAL FIBROSARCOMA DEVELOPMENT
VIVANCO MD; JOHNSON R; GALANTE PE; HANAHAN D; YAMAMOTO KR
Journal article: NATURE. 1994;372(6507):710
Erratum: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
Araki E; Lipes MA; Patti M-E; Claus Brüning J; Haag B; Johnson RS; Ronald Kahn C
Journal article: NATURE. 1994;372(6502):186-190
ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE
ARAKI E; LIPES MA; PATTI ME; BRUNING JC; HAAG B; JOHNSON RS; KAHN CR
Journal article: BRAIN RESEARCH. 1994;651(1-2):275-282
BEHAVIORAL-ASSESSMENT OF C-FOS MUTANT MICE
PAYLOR R; JOHNSON RS; PAPAIOANNOU V; SPIEGELMAN BM; WEHNER JM
Journal article: EMBO JOURNAL. 1994;13(13):3094-3103
TARGETED DISRUPTION OF THE C-FOS GENE DEMONSTRATES C-FOS-DEPENDENT AND C-FOS-INDEPENDENT PATHWAYS FOR GENE-EXPRESSION STIMULATED BY GROWTH-FACTORS OR ONCOGENES
HU ED; MUELLER E; OLIVIERO S; PAPAIOANNOU VE; JOHNSON R; SPIEGELMAN BM
Journal article: BIOLOGY OF REPRODUCTION. 1994;50(5):1040-1048
EFFECT OF A NULL MUTATION OF THE C-FOS PROTOONCOGENE ON SEXUAL-BEHAVIOR OF MALE-MICE
BAUM MJ; BROWN JJG; KICA E; RUBIN BS; JOHNSON RS; PAPAIOANNOU VE
Journal article: MOLECULAR AND CELLULAR BIOLOGY. 1994;14(3):1566-1574
Normal Peripheral T-Cell Function in c-Fos-Deficient Mice
Jain J; Nalefski EA; Mccaffrey PG; Johnson RS; Spiegelman BM; Papaioannou V; Rao A
Journal article: MOLECULAR AND CELLULAR BIOLOGY. 1994;14(3):1566-1574
NORMAL PERIPHERAL T-CELL FUNCTION IN C-FOS-DEFICIENT MICE
JAIN JN; NALEFSKI EA; MCCAFFREY PG; JOHNSON RS; SPIEGELMAN BM; PAPAIOANNOU V; RAO A
Journal article: JOURNAL OF IMMUNOLOGY. 1993;151(3):1528-1534
TARGETED DISRUPTION OF CD43 GENE ENHANCES T-LYMPHOCYTE ADHESION
MANJUNATH N; JOHNSON RS; STAUNTON DE; PASQUALINI R; ARDMAN B
Journal article: GENES & DEVELOPMENT. 1993;7(7B):1309-1317
A NULL MUTATION AT THE C-JUN LOCUS CAUSES EMBRYONIC LETHALITY AND RETARDED CELL-GROWTH IN CULTURE
JOHNSON RS; VANLINGEN B; PAPAIOANNOU VE; SPIEGELMAN BM
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1993;90(9):3913-3917
MICE LACKING MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I AND CLASS-II MOLECULES
GRUSBY MJ; AUCHINCLOSS H; LEE R; JOHNSON RS; SPENCER JP; ZIJLSTRA M; JAENISCH R; PAPAIOANNOU VE; GLIMCHER LH
Journal article: CELL. 1992;71(4):577-586
PLEIOTROPIC EFFECTS OF A NULL MUTATION IN THE C-FOS PROTOONCOGENE
JOHNSON RS; SPIEGELMAN BM; PAPAIOANNOU V
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992;89(19):9306-9310
GROWTH AND DIFFERENTIATION OF EMBRYONIC STEM-CELLS THAT LACK AN INTACT C-FOS GENE
FIELD SJ; JOHNSON RS; MORTENSEN RM; PAPAIOANNOU VE; SPIEGELMAN BM; GREENBERG ME
Journal article: CELL. 1992;68(5):869-877
RAG-1-DEFICIENT MICE HAVE NO MATURE LYMPHOCYTES-B AND LYMPHOCYTES-T
MOMBAERTS P; IACOMINI J; JOHNSON RS; HERRUP K; TONEGAWA S; PAPAIOANNOU VE
Journal article: SCIENCE. 1991;253(5026):1417-1420
DEPLETION OF CD4+ T-CELLS IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II DEFICIENT MICE
GRUSBY MJ; JOHNSON RS; PAPAIOANNOU VE; GLIMCHER LH
Journal article: SCIENCE. 1989;245(4923):1234-1236
TARGETING OF NONEXPRESSED GENES IN EMBRYONIC STEM-CELLS VIA HOMOLOGOUS RECOMBINATION
JOHNSON RS; SHENG M; GREENBERG ME; KOLODNER RD; PAPAIOANNOU VE; SPIEGELMAN BM
Journal article: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY. 1987;45(7):608-612
DIAGNOSIS AND TREATMENT OF VONWILLEBRANDS DISEASE
JOHNSON RS; HELDT LV; KEATON WM
Journal article: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY. 1987;45(6):533-536
MANAGEMENT OF A RUPTURED PSEUDOANEURYSM OF THE SPHENOPALATINE ARTERY FOLLOWING A LE-FORT-I OSTEOTOMY
HEMMIG SB; JOHNSON RS; FERRARO N
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1985;162(4):1193-1207
HLA CLASS-II REGULATION AND STRUCTURE - ANALYSIS WITH HLA-DR3 AND HLA-DP POINT MUTANTS
PIOUS D; DIXON L; LEVINE F; COTNER T; JOHNSON R
Journal article: FERTILITY AND STERILITY. 1984;42(4):526-530
STERILIZATION FAILURES WITH BIPOLAR TUBAL CAUTERY
AYERS JWT; JOHNSON RS; ANSBACHER R; MENON M; LAFERLA JJ; ROBERTS JA
Journal article: JOURNAL OF PROSTHETIC DENTISTRY. 1983;49(2):207-209
A CAST DOWEL-CORE TECHNIQUE FOR MULTIROOTED TEETH WITH DIVERGENT CANALS
ZIEBERT GJ; JOHNSON RS
Journal article: STATE GOVERNMENT. 1975;48(4):226-231
STATE INVESTMENT PORTFOLIO - CASE FOR CERTIFICATES OF DEPOSIT
HACKBART MM; JOHNSON RS
Journal article: MEDICAL LABORATORY TECHNOLOGY. 1974;31(4):299-303
IMPROVED BLOOD CULTURE MEDIUM
COETZEE EFC; JOHNSON RSA
Journal article: BMJ-BRITISH MEDICAL JOURNAL. 1961;1(523):1369-&
FATAL APLASTIC ANAEMIA AFTER TREATMENT OF THYROTOXICOSIS WITH POTASSIUM PERCHLORATE
JOHNSON RS; MOORE WG
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Preprint: BIORXIV. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Preprint: BIORXIV. 2022
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha P; Minogue E; Krause L; Hess R; Bargiela D; Wadsworth B; Barbieri L; Brombach C; Foskolou I; Bogeski I; Veliça P; Johnson R
Preprint: BIORXIV. 2022
Glutarate regulates T cell function and metabolism
Minogue E; Cunha P; Quaranta A; Zurita J; Teli SS; Wadsworth B; Hughes R; Grice G; Velica P; Bargiela D; Barbieri L; Wheelock C; Nathan J; Koivunen P; Foskolou I; Johnson R
Preprint: BIORXIV. 2022
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou I; Cunha P; Minogue E; Nicolet B; Guislain A; Jorgensen C; Zandhuis N; Barbieri L; Bargiela D; Nathanael D; Tyrakis P; Palazon A; Wolkers M; Johnson R
Conference publication: ACTA PHYSIOLOGICA. 2022;236:25
Tissue-specific vascular metabolism: role in metastasis
Reiterer M; Mc Erlain T; Eakin A; Johnson R; Branco C
Preprint: BIORXIV. 2021
Lactate regulation of activation in CD8+ T cells
Barbieri L; Veliça P; Gameiro P; Cunha P; Foskolou I; Bargiela D; Rundqvist H; Johnson R
Review: FEBS JOURNAL. 2021;288(24):7143-7161
Oxygen regulation of TET enzymes
Matuleviciute R; Cunha PP; Johnson RS; Foskolou IP
Preprint: RESEARCH SQUARE. 2021
Metabolic turnover and dynamics of RNA modifications by 13C labelling
Gameiro P; Foskolou I; Encheva V; Santos MSD; MacRae J; Johnson R; Ule J
Preprint: RESEARCH SQUARE. 2021
Metabolic turnover and dynamics of RNA modifications by 13C labelling
Gameiro PA; Foskolou I; Encheva V; Santos MSD; MacRae J; Johnson R; Ule J
Editorial comment: ACTA PHYSIOLOGICA. 2021;231(1):e13494
Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE) Response
Gojkovic M; Velica P; Rundqvist H; Johnson RS
Preprint: BIORXIV. 2020
MICROVASCULAR ENDOTHELIAL CELL ADAPTATION TO HYPOXIA IS ORGAN-SPECIFIC AND CONDITIONED BY ENVIRONMENTAL OXYGEN
Reiterer M; Eakin A; Burke A; Johnson R; Branco C
Preprint: BIORXIV. 2020
Modified Hypoxia Inducible Factor expression in CD8+ T cells increases anti-tumor efficacy
Veliça P; Cunha PP; Vojnovic N; Foskolou IP; Bargiela D; Gojkovic M; Rundqvist H; Johnson RS
Corrigendum: SCIENTIFIC REPORTS. 2020;10(1):1627
Acute and chronic hypoxia differentially predispose lungs for metastases (vol 9, 10246, 2019)
Reiterer M; Colaco R; Emrouznejad P; Jensen A; Rundqvist H; Johnson RS; Branco C
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):336
Cd8+T-cell Depletion Abolishes The Anti-metastatic Effects Of Voluntary Running In A Mouse Model Of Breast Cancer
Rundqvist H; Barbieri L; Velica P; Mijwel S; Ostman A; Johnson R
Preprint: BIORXIV. 2019
Lactate potentiates differentiation and expansion of cytotoxic T cells
Rundqvist H; Veliça P; Barbieri L; Gameiro P; Cunha P; Gojkovic M; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Pérez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson R
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Lactate Potentiates Differentiation and Expansion of Cytotoxic T Cells
Rundqvist H; Velica P; Barbieri L; Gameiro P; Cunha PP; Gojkovic M; Bargiela D; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Perez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson RS
Conference publication: BLOOD. 2018;132:3842
Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms
Ho Y-H; del Toro R; Rivera-Torres J; Rak J; Korn C; Garcia-Garcia A; Kubovcakova L; Macias D; Arranz L; Gonzalez-Gomez C; Wittner M; Nienhold R; Waller AK; Foster HR; Lopez-Otin C; Johnson RS; Nerlov C; Vainchenker W; Ghevaert C; Louache F; Skoda RC; Andres V; Mendez-Ferrer S
Letter: NATURE. 2018;561(7724):e33-e40
The role of Olfr78 in the breathing circuit of mice
Torres-Torrelo H; Ortega-Saenz P; Macias D; Omura M; Zhou T; Matsunami H; Johnson RS; Mombaerts P; Lopez-Barneo J
Corrigendum: ELIFE. 2018;7:e38781
HIF-2α is essential for carotid body development and function (vol 7, e34681, 2018)
Macias D; Cowburn AS; Torres-Torrelo H; Ortega-Saenz P; Lopez-Barneo J; Johnson R
Preprint: BIORXIV. 2018
HIF-2α is essential for carotid body development and function
Macías D; Cowburn A; Torres-Torrelo H; Ortega-Sáenz P; López-Barneo J; S. Johnson R
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2018;48:44-45
Perivascular macrophages regulate blood flow following tissue damage
Vagesjo E; Seignez C; Christoffersson G; Herrera-Hidalgo C; Giraud A; Korsgren O; Rundqvist H; Essand M; Holm L; Johnson R; Phillipson M
Conference publication: CANCER SCIENCE. 2018;109:1161
Distinct roles of VEGF isoforms as negative regulator of extracellular matrix deposition for tumor progression
Yamamoto H; Stockmann C; Johnson RS
Conference publication: THORAX. 2017;72:a67-A68
HIF2A DELETION IN THE PULMONARY ENDOTHELIUM PREVENTS HYPOXIA-INDUCED PULMONARY HYPERTENSION
Cowburn AS; Crosby A; Macias-Gutierrez D; Southwood M; Branco C; Morrell N; Chilvers ER; Johnson RS
Other: EXPERIMENTAL CELL RESEARCH. 2017;356(2):115
Lorenz Poellinger
Giaccia A; Johnson RS
Conference publication: CANCER RESEARCH. 2017;77:pd8-05-pd8-05
Comparative analysis of the genomic landscape of breast cancers from women of African and European ancestry
Olopade OI; Pitt JJ; Riester M; Odetunde A; Yoshimatsu T; Labrot E; Ademola A; Sanni A; Okedere B; Mahan S; Nwosu I; Leary R; Ajani M; Johnson RS; Sveen E; Zheng Y; Wang S; Fitzgerald DJ; Grundstad J; Tuteja J; Clayton W; Khramtsova G; Oludara M; Omodele F; Benson O; Adeoye A; Morhason-Bello O; Ogundiran T; Babalola C; Popoola A; Morrissey M; Chen L; Huo D; Falusi A; Winckler W; Obafunwa J; Papoutsakis D; Ojengbede O; White KP; Ibrahim N; Oluwasola O; Barretina J
Conference publication: CYTOKINE. 2017;100:190
Glial galectin-9 plays anovel role inhypoxic tumor environment
Change CY; Baek S; Kim H-S; Jeon S-B; Johnson RS; Park EJ
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):256-257
They activated CD8+T-cells in low oxygen. What happens next will blow your mind!
Velica P; Rundqvist H; Gojkovic M; Johnson RS
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):309
Myeloid hypoxia leads to reduced metastatic success
Gojkovic M; Velica P; Darmasaputra G; Rundqvist H; Johnson R
Conference publication: ACTA PHYSIOLOGICA. 2017;219:43
No local or systemic effects of cutaneous exposure to hypobaric hypoxia in humans
Siebenmann C; Keramidas M; Rundqvist H; Mijwel S; Cowburn A; Johnson R; Eiken O
Editorial comment: CANCER CELL. 2016;30(6):831
To PFKFB3 or Not to PFKFB3, That Is the Question
Branco C; Johnson RS
Other: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(49):13938-13940
Profile of William Kaelin, Peter Ratcliffe, and Greg Semenza, 2016 Albert Lasker Basic Medical Research Awardees Fire in the air, fire in the cell
Johnson RS
Conference publication: THORAX. 2016;71:a61-A62
HYPOXIA PRECONDITIONS THE INNATE IMMUNE RESPONSE TO ACUTE BACTERIAL PULMONARY INFECTIONS
Dickinson RS; Thompson AAR; Thomson JP; Murphy F; Marriott HM; Tavares A; Willson J; Williams L; Lewis A; Forbes S; Stimson RH; Hameed AG; Preston JA; Lawrie A; Finisguerra V; Mazzone M; Foster SJ; Chilvers ER; Cowburn AS; Dockrell DH; Johnson RS; Meehan RR; Whyte MKB; Walmsley SR
Conference publication: CANCER RESEARCH. 2016;76:c10
The role of FIH in macrophage function
Gojkovic M; Rundqvist H; Velica P; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:a12
The immune composition of a spontaneous mouse breast cancer
Velica P; Rundqvist H; Gojkovic M; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:836
Effect of voluntary running on metastasis in a mouse model of breast cancer
Mijwel S; Rundqvist H; Lindholm C; Strell C; Roswall P; Pietras K; Johnson RS; Ostman A
Conference publication: CANCER RESEARCH. 2016;76:a21
Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa
Branco C; Rundqvist H; Colaco R; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:a19
Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors
Evans CE; Palazon A; Sim J; Tyrakis PA; Bendahl P-O; Belting M; Rundqvist H; Branco C; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:pr03
Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa
Branco C; Rundqvist H; Colaco R; Johnson RS
Corrigendum: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3):djv434
Erratum.
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193
Hif2α Deletion In The Pulmonary Endothelial Prevents Hypoxia-Induced Pulmonary Hypertension
Cowburn AS; Crosby A; Macias-Gutierrez D; Southwood M; Crotty-Alexander L; Morrell NW; Chilvers ER; Johnson RS; Johnson RS
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2016;25(1):11-15
Cutaneous control of blood pressure
Johnson RS; Titze J; Weller R
Conference publication: BREAST CANCER RESEARCH AND TREATMENT. 2016;159(1):195
Endothelial HIF-a modulate cancer metastatic potential by affecting vascular permeability and pro-metastatic macrophage infiltration
Branco C; Evans C; Colaco R; Rundqvist H; Johnson R
Editorial comment: CANCER DISCOVERY. 2015;5(6):584-585
Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress
Sim J; Johnson RS
Conference publication: CANCER RESEARCH. 2015;75(1):b12
Molecular mechanisms of HIF-1a and HIF-2a activation in nonmalignant cells at the premetastatic niche: Effects on metastatic success
Branco-Price C; Palazon A; Xie J; Johnson RS
Conference publication: CLINICAL & EXPERIMENTAL METASTASIS. 2015;32(3):234-235
Myeloid cell derived vascular endothelial growth factor promotes pulmonary metastasis by increasing endothelial permeability
Rundqvist H; Stockmann C; Ponte R; Doedens A; Johnson RS
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2015;10(9):S394-S395
Microthrombosis Enhances Extravasation via Myeloid HypoxiaInducible Factors
Evans CE; Prodger A; Branco-Price C; Palazon A; Tyrakis P; Sim J; Rundqvist H; Bendahl P-O; Belting M; Johnson RS
Review: IMMUNITY. 2014;41(4):518-528
HIF Transcription Factors, Inflammation, and Immunity
Palazon A; Goldrath AW; Nizet V; Johnson RS
Editorial comment: DEVELOPMENTAL CELL. 2014;30(2):116-117
A Whiter Shade of Gray: HIF and Coordination of Angiogenesis with Postnatal Myelination
Sim J; Johnson RS
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2014;189
Hypoxia Inducible Factor (hif)-2α In Myeloid Cells Promotes Allergic Inflammatory Airways Disease Pathogenesis In Mice
Dewitz C; Nicatia S; McEachern EK; Rojas I; Johnson R; Nizet V; Alexander LEC
Conference publication: ANTICANCER RESEARCH. 2014;34(10):6145-6146
STROMAL HYPOXIA AND METASTASIS IN BREAST CANCER
Rundqvist H; Stockmann C; Branco-Price C; Doedens A; Johnson RS
Review: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):105-112
Tumour oxygenation: implications for breast cancer prognosis
Rundqvist H; Johnson RS
Conference publication: CANCER RESEARCH. 2013;73:b7
Hypoxia-inducible factor 1 mediates thrombosis-associated cancer progression
Evans CE; Branco-Price C; Humphries J; Wadoodi A; Saha P; Kim J-W; Belting M; Smith A; Johnson RS
Conference publication: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2013;131(2):ab239
Hypoxia Inducible Factor (HIF) Alpha Subunits Modulate Eosinophil Migration, Oxidative Burst, and Degranulation
Alexander LEC; Nicatia S; McEachern E; Johnson R; Broide DH; Nizet V
Conference publication: THORAX. 2012;67:a1
HYPOXIA-INDUCIBLE FACTOR 2α REGULATES NEUTROPHILIC INFLAMMATION IN HUMANS, MICE AND ZEBRAFISH
Thompson AAR; Elks PM; Marriott HM; Higgins KR; Parmar S; Shaw G; Eamsamarng S; McGrath EE; Formenti F; Van Eeden FJ; Kinnula VL; Pugh CW; Sabroe I; Dockrell DH; Chilvers ER; Robbins PA; Simon MC; Johnson RS; Renshaw SA; Whyte MKB; Walmsley SR
Conference publication: 2012;:a4173
HIF-2± Regulates Neutrophilic Inflammation In Humans, Mice And Zebrafish
Thompson AAR; Elks PM; Marriott HM; Higgins KR; Shaw G; Parmar S; Formenti F; Van Eden FJ; Pugh CW; Sabroe I; Dockrell DH; Robbins PA; Simon MC; Johnson RS; Renshaw SA; Whyte MKB; Walmsley SR
Conference publication: FASEB JOURNAL. 2012;26:704.15
HIF-1a gene deletion in the nucleus tractus solitarii (NTS) blunts ventilatory acclimatization to hypoxia (VAH)
Go AD; Fu Z; Johnson RS; Powell FL
Review: NATURE REVIEWS CANCER. 2011;12(1):9-22
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith B; Johnson RS; Simon MC
Conference publication: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2011;30(4):S130
Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection In Mouse Cardiac Allografts
Keranen MAI; Syrjala S; Krebs R; Tuuminen R; Johnson RS; Nykanen AI; Lemstrom KB
Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(3):797-801
A Wound Size-Dependent Effect of Myeloid Cell-Derived Vascular Endothelial Growth Factor on Wound Healing
Stockmann C; Kirmse S; Helfrich I; Weidemann A; Takeda N; Doedens A; Johnson RS
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2011;48:181
The physiology of vascular hypoxic response
Johnson R
Conference publication: BLOOD. 2011;118(21):1816
Physiology of HIF Regulation of Erythropoiesis
Johnson RS
Conference publication: CIRCULATION. 2011;124(21)
Switching of Hif-α Isoforms is Critical in the Resolution of Inflammation
Takeda N; Abe H; Senba H; Johnson R; Manabe I; Nagai R
Book chapter: TUMOUR-ASSOCIATED MACROPHAGES. 2011;p. 105-115
Vascular Endothelial Growth Factor and Tumour-Associated Macrophages
Stockmann C; Johnson RS
Conference publication: THORAX. 2010;65:a57
MACROPHAGE DELETION OF VHL RESULTS IN ALTERNATIVE ACTIVATION AND ENHANCED LUNG FIBROSIS INDEPENDENT OF HIF-1
Gibbons MA; Fitch PM; MacDuff A; Mackinnon AC; Forbes SJ; Aidinis V; Johnson RS; Sethi T; Haslett C; Rossi AG; Simpson AJ; Howie SEM; Hirani N
Editorial comment: CANCER CELL. 2010;17(6):533-534
Tumor Vessels Are Eph-ing Complicated
Branco-Price C; Johnson RS
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2010;181:a1961
Potential Role For Macrophage Hypoxia And HIF-1 Activation In Enhancing Bleomycin-induced Lung Fibrosis
Gibbons M; Fitch PM; MacKinnon AC; MacDuff A; Aidinis V; Johnson RS; Forbes SJ; Sethi T; Haslett C; Rossi AG; Simpson AJ; Howie SEM; Hirani N
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2010;1192:322-326
Role of HIF-1α in skeletal development
Wan C; Shao J; Gilbert SR; Riddle RC; Long F; Johnson RS; Schipani E; Clemens TL
Conference publication: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2010;29(2):S116
Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection in Mouse Cardiac Allografts
Keranen MAI; Krebs R; Johnson RS; Nykanen AI; Lemstrom KB
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2010;51(13)
von Hippel-Lindau Tumor Suppressor Protein is Required for Transition From Embryonic to Adult Circulatory System in Retina
Kurihara T; Kubota Y; Ozawa Y; Noda K; Johnson RS; Goda N; Ishida S; Tsubota K; Suda T; Okano H
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2010;51(13)
Astrocyte Hypoxic Response is Essential for Pathological but Not Developmental Angiogenesis of the Retina
Krohne TU; Weidennann A; Aguilar E; Kurihara T; Takeda N; Dorrell MI; Simon MC; Haase VH; Johnson RS; Friedlander M
Conference publication: FASEB JOURNAL. 2010;24
Effects of HIF-1α gene deletion in respiratory centers on ventilatory acclimatization to hypoxia (VAH)
Go A; Fu Z; Johnson RS; Powell FL
Conference publication: AMERICAN JOURNAL OF TRANSPLANTATION. 2010;10:386-387
Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection in Rat Cardiac Allografts
Keranen MAI; Syrjala S; Krebs R; Johnson RS; Nykanen AI; Lemstrom KB
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2010;345:121-139
Hypoxia and Metastasis in Breast Cancer
Rundqvist H; Johnson RS
Review: NATURE REVIEWS IMMUNOLOGY. 2009;9(9):609-617
Interdependence of hypoxic and innate immune responses
Nizet V; Johnson RS
Editorial comment: DEVELOPMENTAL CELL. 2009;16(6):781-782
You Don't Need a PHD to Grow a Tumor
Kim J-W; Johnson RS
Corrigendum: NATURE MEDICINE. 2009;15(4):462
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis (vol 12, pg 793, 2006)
Tam BYFY; Wei K; Rudge JS; Hoffman J; Holash J; Park S-K; Yuan J; Hefner C; Chartier C; Lee J-S; Jiang S; Nayak NR; Kuypers FA; Ma L; Sundram U; Wu G; Garcia JA; Schrier SL; Maher JJ; Johnson RS; Yancopoulos GD; Mulligan RC; Kuo CJ
Review: KIDNEY INTERNATIONAL. 2009;75(7):682-688
Nonrenal regulation of EPO synthesis
Weidemann A; Johnson RS
Corrigendum: NATURE. 2009;457(7233):1168
A role for VEGF as a negative regulator of pericyte function and vessel maturation (vol 456, pg 809, 2008)
Greenberg JI; Shields DJ; Barillas SG; Acevedo LM; Murphy E; Huang J; Scheppke L; Stockmann C; Johnson RS; Angle N; Cheresh DA
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2009;648:369-376
Oxygen Sensing in the Brain - Invited Article
Powell FL; Kim CB; Johnson RS; Fu Z
Editorial comment: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2008;18(5):395-396
Putting the tissue and environmental 'context' into differentiation and gene regulation
Bray S; Johnson RS
Review: CELL DEATH AND DIFFERENTIATION. 2008;15(4):621-627
Biology of HIF-1α
Weidemann A; Johnson RS
Conference publication: FASEB JOURNAL. 2008;22:1016.7
HIF-1 is not a critical determinant for metabolic zonation in liver acinus
Goda N; Ochiai D; Fujiki N; Johnson RS; Suematsu M
Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2008;120:14
Function of hypoxia-inducible factor (HIF)-1α in dendritic cells
Koehler T; Johnson RS; Weighardt H; Foerster I
Conference publication: BIRTH DEFECTS RESEARCH. 2008;82(5):314
The role of HIF in mesenchyme differentiation and limb development
Ppovot S; Zinyk D; Gunes Y; Kathri R; Le Q; Kronenberg HM; Johnson RS; Longaker MT; Schipani E; Giaccia AJ
Conference publication: FASEB JOURNAL. 2008;22
Relationship of Hypoxia to inflammation and angiogenesis
Johnson RS
Conference publication: FASEB JOURNAL. 2008;22
Hypoxia and Inflammation: Relationship to Angiogenesis
Johnson RS
Conference publication: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2008;27(2):S191
Constantly stable HIF-1α in myeloid cells prevents acute rejection in rat cardiac Allografts
Kerdnen MAJ; Tuuminen R; Nykanen AI; Tavast E; Koskinen PK; Johnson RS; Lemstrom KB
Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2007;85(12):1339-1346
Hypoxia inducible factor (HIF) function in innate immunity and infection
Zinkernagel AS; Johnson RS; Nizet V
Editorial comment: BLOOD. 2007;110(10):3492-3493
A wrinkle in the unfolding of hypoxic response: HIF and ATF4
Weidemann A; Johnson RS
Review: CANCER AND METASTASIS REVIEWS. 2007;26(2):281-290
Hypoxia: A key regulator of angiogenesis in cancer
Liao D; Johnson RS
Editorial comment: MOLECULAR CELL. 2007;26(2):157-158
Can irradiated tumors take NO for an answer?.
Johnson RS; Huang LE
Editorial comment: CELL. 2007;129(1):29-30
Waiting to inhale: HIF-1 modulates aerobic respiration
Boutin AT; Johnson RS
Conference publication: AMERICAN JOURNAL OF HEMATOLOGY. 2007;82(6):588
Microsatellite-dependent regulatory variation of NRAMP1/SLC11A1
Bayele HK; Peyssonnaux C; Giatromanolaki A; Mohamed HS; Giorgio S; Koukourakis M; Johnson RS; Blackwell JM; Nizet V; Sral SKS
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2007;618:229-244
The role of HIF-1 in hypoxic response in the skeletal muscle
Mason S; Johnson RS
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2007;435:87-105
Transgenic models to understand hypoxia-inducible factor function
Doedens A; Johnson RS
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2006;43:45
Increased oxygen consumption in hepatocyte-specific HIF-1-targeted mice
Tsukada K; Tajima T; Kawamura T; Goda N; Johnson RS; Suematsu M
Conference publication: AMERICAN JOURNAL OF KIDNEY DISEASES. 2006;47(4):A22
HIF1 and VHL in murine podocytes are dispensable for normal glomerular development
Brukamp K; Jim B; Moeller MJ; Holzman LB; Johnson RS; Haase VH
Conference publication: CIRCULATION. 2006;114(18):4
Regulation of reactive oxygen species production and reactive oxygen species-related gene expression by hypoxia inducible factor-1α
Huang Y; Jovin IS; Hao Z; Lei L; Liu D; Johnson RS; Giordano FJ
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21:S50
Conditional deletion of HIF-1α in the condensing mesenchyme delays angiogenesis and impairs intramembranous and endochondral bone development.
Li QN; Gilbert SR; Cao X; Wan C; Serra R; Song BE; Johnson RS; Long F; Clemens TL
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21:S49
Hif-1alpha regulates differentiation of the limb bud mesenchyme and joint development.
Provot S; Zinyk D; Gunes Y; Kronenberg HM; Johnson RS; Longaker MT; Giaccia AJ; Schipani E
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21:S58
The hypoxia-inducible factor pathway couples angiogenesis to osteogenesis during skeletal development.
Wang Y; Wan C; Liu X; Bouxsein ML; Faugere M; Johnson RS; Haase VH; Gerstenfeld LC; Schipani E; Clemens TL
Editorial comment: DEVELOPMENTAL CELL. 2005;9(5):574-576
A new Notch in the HIF belt: How hypoxia impacts differentiation
Cejudo-Martin P; Johnson RS
Editorial comment: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2005;16(4-5):461
Biology of hypoxia - Introduction
Johnson RS
Conference publication: BIOLOGY OF REPRODUCTION. 2005;:119
HIF-1 is necessary for follicular maturation.
Alam H; Flynn MP; Maizels ET; Park Y; Johnson RS; Hunzicker-Dunn M
Review: GENES & DEVELOPMENT. 2004;18(18):2183-2194
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
Giaccia AJ; Simon MC; Johnson R
Other: CANCER RESEARCH. 2004;64(9):3350-3356
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Kaufman B; Scharf O; Arbeit J; Ashcroft M; Brown JM; Bruick RK; Chapman JD; Evans SM; Giaccia AJ; Harris AL; Huang E; Johnson R; Kaelin W; Koch CJ; Maxwell P; Mitchell J; Neckers L; Powis G; Rajendran J; Semenza GL; Simons J; Storkebaum E; Welch MJ; Whitelaw M; Melillo G; Ivy SP
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2004;14(1):81-85
HIF-1 and hypoxic response: the plot thickens
Poellinger L; Johnson RS
Conference publication: JOURNAL OF HEPATOLOGY. 2004;40:18
Conditional loss of HIF-1α delays liver regeneration and aggravates toxicity after carbon tetrachloride administration
Cramer T; Benckert C; Johnson RS; Wiedenmann B; Hoecker M
Conference publication: THORAX. 2004;59(1):2
Hypoxia inhibits neutrophil apoptosis via hypoxia inducible factor (HIF)-1α-dependent regulation of NFκB
Walmsley SR; Print C; Johnson RS; Cramer T; Condliffe AM; Chilvers ER
Conference publication: CIRCULATION. 2004;110(17):83
Hypoxia-inclucible factor (HIF)-1 α influences vascular remodeling associated with altered flow
Liu DG; Lei L; Huang Y; Jovin IS; Hickey RP; Yu J; Johnson RS; Sessa WC; Giordano FJ
Conference publication: CIRCULATION. 2004;110(17):25
Endothelial expression of HIF-1α is a critical determinant of whole-organ glucose uptake and oxidation
Huang Y; Liu DG; Hickey RP; Lei L; Yeh J; Johnson RS; Russell R; Giordano FJ
Conference publication: CIRCULATION. 2004;110(17):45
Malignant transformation of heart muscle in the absence of the von Hippel-Lindau protein
Lei L; Mason S; Liu DG; Huang Y; Hickey RP; Johnson RS; Giordano FJ
Conference publication: AMERICAN JOURNAL OF TRANSPLANTATION. 2004;4:514
Hypoxia inducible factor-1α regulates TCR signal transduction.
Neumann AK; Biju MP; Johnson RS; Haase VH; Turka LA
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2004;19:S15
Conditional disruption of hypoxia inducible factor 1 α in mouse osteoblasts reduces bone volume.
Deng L; Akeno N; Mukherjee A; Bouxsein M; Faugere M; Johnson RS; Clemens TL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2004;63:146
HIF-1alpha plays a critical role in chondrocytes during low oxygen tension: Implications for osteoarthritis
Pfander D; Cramer T; Johnson RS; Swoboda B
Review: NATURE REVIEWS DRUG DISCOVERY. 2003;2(10):803-811
HIF-1 as a target for drug development
Giaccia A; Siim BG; Johnson RS
Review: ANTIOXIDANTS & REDOX SIGNALING. 2003;5(4):467-473
HIF-1 in cell cycle regulation, apoptosis, and tumor progression
Goda N; Dozier SJ; Johnson RS
Conference publication: HEPATOLOGY. 2003;38(4):270A
Oxygen modulation of cytochrome P450 pathways: Role of oxygen gradients and HIF-1alpha in hepatocytes in vitro.
Allen JW; Johnson RS; Bhatia SN
Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14:588A
HIF-1-regulated gene expression in murine kidneys and its implication for renal fibrosis
Higgins DF; Akai Y; Biju MP; Johnson RS; Haase VH
Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14:344A
A novel role for the VHL tumor suppressor in thymocyte apoptosis.
Biju MP; Neumann AK; Bensinger SJ; Johnson RS; Turka LA; Haase VH
Corrigendum: CELL. 2003;113(3):419
HIF-1α is essential for myeloid cell-mediated inflammation (vol 112, pg 648, 2003)
Cramer T; Yamanishi Y; Clausen BE; Förster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS
Corrigendum: JOURNAL OF CELL SCIENCE. 2003;116(10):2113
HIF-1α controls extracellular matrix synthesis by epiphyseal chondrocytes (vol 116, pg 1819, 2003)
Pfander D; Cramer T; Schipani E; Johnson RS
Corrigendum: JOURNAL OF CELL BIOLOGY. 2003;161(2):441
c-jun is essential for sympathetic neuronal death induced by NFG withdrawal but not by p75 activation (vol 158, pg 453, 2002)
Palmada M; Kanwal S; Rutkoski N; Gustafson-Brown C; Johnson RS; Wisdom R; Carter BD
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2003;62:111
HIF-1alpha controls energy generation and matrix synthesis by murine chondrocytes
Pfander D; Cramer T; Johnson RS; Swoboda B
Corrigendum: CANCER CELL. 2002;1(4):403
Two HIFs may be better than one (vol 1, pg 212, 2002)
Seagroves T; Johnson RS
Editorial comment: CANCER CELL. 2002;1(3):211-213
Two HIFs may be better than one
Seagroves T; Johnson RS
Conference publication: GASTROENTEROLOGY. 2002;122(4):A400
HIF-1alpha expression in myeloid cells as an essential regulator of inflammation
Cramer T; Foerster I; Johnson RS
Conference publication: GASTROENTEROLOGY. 2002;122(4):A6
Hypoxia-inducible factor-1 (HIF-1) is protective for experimental colitis
Karhausen JA; Furuta GT; Haase VH; Jaenisch R; Johnson RS; Colgan SP
Conference publication: CIRCULATION. 2002;106(19):316
Physiologic and gene expression effects of conditional HIF1α deletion from cardiac and smooth muscle
Huang Y; Yeh JL; Hickey RP; Johnson RS; Giordano FJ
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2002;13:175A
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
Putkey FR; Cramer T; Morphew MK; Silk AD; Johnson RS; McIntosh JR; Cleveland DW
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2002;17:S160-S161
The tumor suppressor gene VHL is a critical modulator of cell proliferation and cell growth in the mammalian growth plate.
Schipani E; Kobayashi T; MacLean HE; Knight MC; Johnson RS; Haase V
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2001;11(1):35-40
Angiogenesis: the role of the microenvironment in flipping the switch
Giordano FJ; Johnson RS
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2001;16:S137
Essential role of HIF-1alpha in growth plate development.
Schipani E; Ryan HE; Kobayashi T; Knight M; Johnson RS
Conference publication: BLOOD. 1998;92(10):172A-173A
Characterization of the structure and function of CD39.
Gayle RB; Gimpel SD; Maliszewski CR; Schoenborn MA; Caspary RG; DuBose RF; Ketchem RR; Johnson RS; Wallace AR; Drosopoulos JHF; Islam N; Broekman MJ; Marcus AJ
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Increasing immunotherapeutic efficacy through manipulation of hypoxic response
Swedish Research Council
1 January 2023 - 31 December 2026
Enhancing immunotherapy through manipulation of metabolism
Barncancerfonden
1 January 2023 - 31 December 2023
Johnson, Randall – Developing next stage immunotherapeutics by augmenting hypoxic response
Swedish Cancer Society
1 January 2022
Metabolic and epigenetic regulation of cancer associated fibroblasts by angiotensin II
Canadian Institutes of Health Research
1 June 2021 - 31 August 2024
Oxygen and immunity
Swedish Research Council
1 January 2020 - 31 December 2022
Oxygen and immune response
Wellcome Trust
1 January 2019 - 31 July 2024
Acute deficiency and activation of the immune system in cancer
Swedish Cancer Society
1 January 2018
Tumor hypoxia and the immune system – protective or harmful?
Swedish Research Council
1 January 2017 - 31 December 2019
Mechanism of signal transduction and gene regulation in hypoxia
Swedish Research Council
1 January 2016 - 31 December 2018
Acute deficiency and inflammation in prognosis and treatment of breast cancer
Swedish Cancer Society
1 January 2016
Acute deficiency and inflammation in prognosis and treatment of breast cancer
Swedish Cancer Society
1 January 2015
Hypoxia and inflammation in the spread of breast cancer.
Swedish Cancer Society
1 January 2014
Hypoxia and Inflammation in Breast Cancer Metastasis
Swedish Research Council
1 January 2014 - 31 December 2016
Metabolic Regulation of T cell Immunity
National Institute of Allergy and Infectious Diseases
1 August 2012 - 31 July 2017
The physiology of hypoxic response
Wellcome Trust
1 August 2011 - 31 December 2018
Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
National Institute of Allergy and Infectious Diseases
5 April 2011 - 31 March 2017
Myeloid Vascular Endothelial Growth Factor Expression & its Role in Tumorigenesis
National Cancer Institute
6 January 2011 - 31 December 2015
Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections
National Institute of Allergy and Infectious Diseases
2 August 2010 - 31 July 2011
Hypoxic response and inflammation: role in breast cancer progression.
Susan G. Komen Breast Cancer Foundation
14 August 2008 - 13 February 2012
The role of HIF-1 in chondrocyte
United States-Israel Binational Science Foundation
1 January 2007
The importance of tumor suppressor von Hippel-Lindau protein (pVHL), and hypoxia inducible factor HIF-1 alpha in metastatic tumor growth
Deutsche Forschungsgemeinschaft
1 January 2006 - 31 December 2009
The importance of the Hypoxia-inducible factors 1 alpha and reactive oxygen species in endothelial cells for interaction between tumor tissue and vessels supplying under the radiotherapy
Deutsche Forschungsgemeinschaft
1 January 2006 - 31 December 2009
Hypoxia-induced Responses and Innate Immunity
National Institute of Allergy and Infectious Diseases
1 May 2005 - 31 January 2009
Biology of Hypoxia
National Institute on Aging
1 April 2004 - 31 March 2005
The Contribution of Hypoxia-Inducible Factor (HIF)-1Alpha and c-jun to Mammary Gland Development and Mammary Tumorigenesis
Susan G. Komen Breast Cancer Foundation
1 May 2000 - 30 April 2003
Hypoxia Response in the Stroma During Tumorigenesis
National Cancer Institute
1 July 1999 - 30 April 2013
GENETIC ANALYSIS OF RAS TRANSFORMATION AND JUN FUNCTION
National Cancer Institute
20 April 1997 - 31 January 2002
IVEM and Image Analysis Resource
National Center for Advancing Translational Sciences
12 December 1988 - 31 March 2014
Specialized Cancer Center Support Grant
National Cancer Institute
31 March 1978 - 30 April 2025
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