Randall S. Johnson

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About me

Randall S. Johnson is the Professor of Molecular Biology and Oxygen Physiology in the Department of Cell and Molecular Biology. His laboratory uses genetic models to study the effects of hypoxia in physiological and pathological contexts, specifically dissecting the roles of different isoforms of Hypoxia Inducible Factors (HIF) as regulators of the hypoxia response in different cell types.

Articles

Journal article: ELIFE. 2024;12
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: ELIFE. 2024;12:rp92707
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1293723
The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy
Bargiela D; Cunha PP; Velica P; Krause LCM; Brice M; Barbieri L; Gojkovic M; Foskolou IP; Rundqvist H; Johnson RS
Journal article: FRONTIERS IN IMMUNOLOGY. 2024;15:1293723
The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy.
Bargiela D; Cunha PP; Veliça P; Krause LCM; Brice M; Barbieri L; Gojkovic M; Foskolou IP; Rundqvist H; Johnson RS
Article: NATURE METABOLISM. 2023;5(11):1840-1843
A century of the Warburg effect
Thompson CB; Vousden KH; Johnson RS; Koppenol WH; Sies H; Lu Z; Finley LWS; Frezza C; Kim J; Hu Z; Bartman CR
Article: NATURE METABOLISM. 2023;5(10):1747-1764
Glutarate regulates T cell metabolism and anti-tumour immunity
Minogue E; Cunha PP; Wadsworth BJ; Grice GL; Sah-Teli SK; Hughes R; Bargiela D; Quaranta A; Zurita J; Antrobus R; Velica P; Barbieri L; Wheelock CE; Koivunen P; Nathan JA; Foskolou IP; Johnson RS
Article: CELL REPORTS. 2023;42(9):113013
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou IP; Cunha PP; Sanchez-Lopez E; Minogue EA; Nicolet BP; Guislain A; Jorgensen C; Kostidis S; Zandhuis ND; Barbieri L; Bargiela D; Nathanael D; Tyrakis PA; Palazon A; Giera M; Wolkers MC; Johnson RS
Article: ELIFE. 2023;12:e84280
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha PP; Minogue E; Krause LCM; Hess RM; Bargiela D; Wadsworth BJ; Barbieri L; Brombach C; Foskolou IP; Bogeski I; Velica P; Johnson RS
Article: CANCER IMMUNOLOGY RESEARCH. 2023;11(3):351-363
Infiltration of Tumors Is Regulated by T cell-Intrinsic Nitric Oxide Synthesis
Cunha PP; Bargiela D; Minogue E; Krause LCM; Barbieri L; Brombach C; Gojkovic M; Marklund E; Pietsch S; Foskolou I; Branco CM; Veli P; Johnson RS
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1101433
Lactate exposure shapes the metabolic and transcriptomic profile of CD8+T cells
Barbieri L; Velica P; Gameiro PA; Cunha PP; Foskolou IP; Rullman E; Bargiela D; Johnson RS; Rundqvist H
Article: CELLS. 2022;11(16):2469
Hyperoxia Reprogrammes Microvascular Endothelial Cell Response to Hypoxia in an Organ-Specific Manner
Reiterer M; Eakin A; Johnson RS; Branco CM
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:837669
Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses
Bargiela D; Cunha PP; Velica P; Foskolou IP; Barbieri L; Rundqvist H; Johnson RS
Article: INTENSIVE CARE MEDICINE EXPERIMENTAL. 2021;9(1):28
Endothelial cell regulation of systemic haemodynamics and metabolism acts through the HIF transcription factors
Lambden S; Cowburn AS; Macias D; Garrud TAC; Krause BJ; Giussani DA; Summers C; Johnson RS
Article: CIRCULATION RESEARCH. 2021;128(11):1694-1707
Perivascular Macrophages Regulate Blood Flow Following Tissue Damage
Vagesjo E; Parv K; Ahl D; Seignez C; Herrera Hidalgo C; Giraud A; Leite C; Korsgren O; Wallen H; Juusola G; Hakovirta HH; Rundqvist H; Essand M; Holm L; Johnson RS; Thalin C; Korpisalo P; Christoffersson G; Phillipson M
Article: CANCER IMMUNOLOGY RESEARCH. 2021;9(4):401-414
Modified Hypoxia-Inducible Factor Expression in CD8⁺ T Cells Increases Antitumor Efficacy
Velica P; Cunha PP; Vojnovic N; Foskolou IP; Bargiela D; Gojkovic M; Rundqvist H; Johnson RS
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2021;53(3):496-504
Inflammation Mediates Exercise Effects on Fatigue in Patients with Breast Cancer
Hiensch AE; Mijwel S; Bargiela D; Wengstrom Y; May AM; Rundqvist H
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:633586
Oxygen-Mediated Suppression of CD8+T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation
Gojkovic M; Cunha PP; Darmasaputra GS; Barbieri L; Rundqvist H; Velica P; Johnson RS
Article: ELIFE. 2020;9:e59996
Cytotoxic T-cells mediate exercise-induced reductions in tumor growth
Rundqvist H; Velica P; Barbieri L; Gameiro PA; Bargiela D; Gojkovic M; Mijwel S; Reitzner SM; Wulliman D; Ahlstedt E; Ule J; Ostman A; Johnson RS
Article: BLOOD ADVANCES. 2020;4(18):4483-4493
The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome
Foskolou IP; Barbieri L; Vernet A; Bargiela D; Cunha PP; Velica P; Suh E; Pietsch S; Matuleviciute R; Rundqvist H; McIntyre D; Smith KGC; Johnson RS
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):336
Cd8+ T-cell Depletion Abolishes The Anti-metastatic Effects Of Voluntary Running In A Mouse Model Of Breast Cancer
Rundqvist H; Barbieri L; Velica P; Mijwel S; Östman A; Johnson R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(26):15160-15171
Macrophage metabolic reprogramming presents a therapeutic target in lupus nephritis
Jing C; Castro-Dopico T; Richoz N; Tuong ZK; Ferdinand JR; Lok LSC; Loudon KW; Banham GD; Mathews RJ; Cader Z; Fitzpatrick S; Bashant KR; Kaplan MJ; Kaser A; Johnson RS; Murphy MP; Siegel RM; Clatworthy MR
Article: ACTA PHYSIOLOGICA. 2020;229(2):e13461
Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE)
Gojkovic M; Darmasaputra GS; Velica P; Rundqvist H; Johnson RS
Journal article: ACCESS MICROBIOLOGY. 2020;2(2)
Metabolite X is a novel biomarker for sepsis diagnosis and treatment
Fitzpatrick S; Lambden S; Macias D; Puthucheary Z; Pietsch S; Mendil L; McPhil M; Johnson R
Article: FRONTIERS IN PHYSIOLOGY. 2020;11:147
2-Hydroxyglutarate Metabolism Is Altered in an in vivo Model of LPS Induced Endotoxemia
Fitzpatrick SF; Lambden S; Macias D; Puthucheary Z; Pietsch S; Mendil L; McPhail MJW; Johnson RS
Article: CELL STEM CELL. 2019;25(3):407-418.e6
Remodeling of Bone Marrow Hematopoietic Stem Cell Niches Promotes Myeloid Cell Expansion during Premature or Physiological Aging
Ho Y-H; del Toro R; Rivera-Torres J; Rak J; Korn C; Garcia-Garcia A; Macias D; Gonzalez-Gomez C; del Monte A; Wittner M; Waller AK; Foster HR; Lopez-Otin C; Johnson RS; Nerlov C; Ghevaert C; Vainchenker W; Louache F; Andres V; Mendez-Ferrer S
Article: SCIENTIFIC REPORTS. 2019;9(1):10246
Acute and chronic hypoxia differentially predispose lungs for metastases
Reiterer M; Colaco R; Emrouznejad P; Jensen A; Rundqvist H; Johnson RS; Branco C
Journal article: 2019
Lactate Potentiates Differentiation and Expansion of Cytotoxic T Cells
Rundqvist H; Velica P; Barbieri L; Gameiro P; Cunha PP; Gojkovic M; Bargiela D; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Perez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson RS
Article: TRANSPLANT INTERNATIONAL. 2019;32(1):95-106
Hypoxia-inducible factor controls immunoregulatory properties of myeloid cells in mouse cardiac allografts - an experimental study
Keraenen MAI; Raissadati A; Nykanen AI; Dashkevich A; Tuuminen R; Krebs R; Johnson RS; Syrjala SO; Lemstrom KB
Article: ELIFE. 2018;7:e34681
HIF-2α is essential for carotid body development and function
Macias D; Cowburn AS; Torres-Torrelo H; Ortega-Saenz P; Lopez-Barneo J; Johnson RS
Article: CELL METABOLISM. 2018;27(4):898-913.e7
The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia
Sim J; Cowburn AS; Palazon A; Madhu B; Tyrakis PA; Macias D; Bargiela DM; Pietsch S; Gralla M; Evans CE; Kittipassorn T; Chey YCJ; Branco CM; Rundqvist H; Peet DJ; Johnson RS
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1624
Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha
Fitzpatrick SF; Gojkovic M; Macias D; Tegnebratt T; Lu L; Samen E; Rundqvist H; Johnson RS
Article: CANCER CELL. 2017;32(5):669-683.e5
An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression
Palazon A; Tyrakis PA; Macias D; Velica P; Rundqvist H; Fitzpatrick S; Vojnovic N; Phan AT; Loman N; Hedenfalk I; Hatschek T; Lovrot J; Foukakis T; Goldrath AW; Bergh J; Johnson RS
Article: ELIFE. 2017;6:e28755
Cardiovascular adaptation to hypoxia and the role of peripheral resistance
Cowburn AS; Macias D; Summers C; Chilvers ER; Johnson RS
Article: ACTA PHYSIOLOGICA. 2017;220(3):361-369
Cutaneous exposure to hypoxia does not affect skin perfusion in humans
Siebenmann C; Keramidas ME; Rundqvist H; Mijwel S; Cowburn AS; Johnson RS; Eiken O
Article: MOLECULAR AND CELLULAR BIOLOGY. 2017;37(13):e00630-e00616
A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase
Luecke-Johansson S; Gralla M; Rundqvist H; Ho JC; Johnson RS; Gradin K; Poellinger L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(24):6382-6387
Metabolic basis to Sherpa altitude adaptation
Horscroft JA; Kotwica AO; Laner V; West JA; Hennis PJ; Levett DZH; Howard DJ; Fernandez BO; Burgess SL; Ament Z; Gilbert-Kawai ET; Vercueil A; Landis BD; Mitchell K; Mythen MG; Branco C; Johnson RS; Feelisch M; Montgomery HE; Griffin JL; Grocott MPW; Gnaiger E; Martin DS; Murray AJ
Article: BIOLOGY OPEN. 2017;6(5):688-697
Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis
Evans CE; Palazon A; Sim J; Tyrakis PA; Prodger A; Lu X; Chan S; Bendahl P-O; Belting M; Von Euler L; Rundqvist H; Johnson RS; Branco C
Article: SCIENCE IMMUNOLOGY. 2017;2(8):eaal2861
Hypoxia determines survival outcomes of bacterial infection through HIF-1α-dependent reprogramming of leukocyte metabolism
Thompson AAR; Dickinson RS; Murphy F; Thomson JP; Marriott HM; Tavares A; Willson J; Williams L; Lewis A; Mirchandani A; Coelho PDS; Doherty C; Ryan E; Watts E; Morton NM; Forbes S; Stimson RH; Hameed AG; Arnold N; Preston JA; Lawrie A; Finisguerra V; Mazzone M; Sadiku P; Goveia J; Taverna F; Carmeliet P; Foster SJ; Chilvers ER; Cowburn AS; Dockrell DH; Johnson RS; Meehan RR; Whyte MKB; Walmsley SR
Article: NEURON. 2016;92(6):1196-1203
A Sensor for Low Environmental Oxygen in the Mouse Main Olfactory Epithelium
Bleymehl K; Perez-Gomez A; Omura M; Moreno-Perez A; Macias D; Bai Z; Johnson RS; Leinders-Zufall T; Zufall F; Mombaerts P
Article: NATURE. 2016;540(7632):236-241
S-2-hydroxyglutarate regulates CD8⁺ T-lymphocyte fate
Tyrakis PA; Palazon A; Macias D; Lee KL; Phan AT; Velica P; You J; Chia GS; Sim J; Doedens A; Abelanet A; Evans CE; Griffiths JR; Poellinger L; Goldrath AW; Johnson RS
Article: IMMUNITY. 2016;45(5):1024-1037
Constitutive Glycolytic Metabolism Supports CD8⁺ T Cell Effector Memory Differentiation during Viral Infection
Phan AT; Doedens AL; Palazon A; Tyrakis PA; Cheung KP; Johnson RS; Goldrath AW
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(31):8801-8806
HIF2α-arginase axis is essential for the development of pulmonary hypertension
Cowburn AS; Crosby A; Macias D; Branco C; Colaco RDDR; Southwood M; Toshner M; Alexander LEC; Morrell NW; Chilvers ER; Johnson RS
Article: NATURE COMMUNICATIONS. 2016;7:11635
HIF-1α-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity
Semba H; Takeda N; Isagawa T; Sugiura Y; Honda K; Wake M; Miyazawa H; Yamaguchi Y; Miura M; Jenkins DMR; Choi H; Kim J-W; Asagiri M; Cowburn AS; Abe H; Soma K; Koyama K; Katoh M; Sayama K; Goda N; Johnson RS; Manabe I; Nagai R; Komuro I
Article: BLOOD. 2016;127(10):1355-1360
Diverse roles of cell-specific hypoxia-inducible factor 1 in cancer-associated hypercoagulation
Evans CE; Bendahl P-O; Belting M; Branco C; Johnson RS
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2016;4:99
Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior
Yamamoto H; Rundqvist H; Branco C; Johnson RS
Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3)
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells (vol 107, djv209, 2015)
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: BMC BIOLOGY. 2015;13:110
Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism
Ashmore T; Roberts LD; Morash AJ; Kotwica AO; Finnerty J; West JA; Murfitt SA; Fernandez BO; Branco C; Cowburn AS; Clarke K; Johnson RS; Feelisch M; Griffin JL; Murray AJ
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209
Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells
Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2015;93(8):891-904
Kidney injury is independent of endothelial HIF-1α
Kalucka J; Schley G; Georgescu A; Klanke B; Roessler S; Baumgartl J; Velden J; Amann K; Willam C; Johnson RS; Eckardt K-U; Weidemann A
Article: DEVELOPMENTAL CELL. 2015;33(5):507-521
HIF1α Represses Cell Stress Pathways to Allow Proliferation of Hypoxic Fetal Cardiomyocytes
Guimaraes-Camboa N; Stowe J; Aneas I; Sakabe N; Cattaneo P; Henderson L; Kilberg MS; Johnson RS; Chen J; McCulloch AD; Nobrega MA; Evans SM; Zambon AC
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(suppl_1)
Abstract 184: Pulmonary Microvascular Thrombosis Enhances Extravasation via Myeloid Hypoxia-Inducible Factors
Evans CE; Branco-Price C; Prodger A; Palazon A; Tyrakis P; Rundqvist H; Bendahl P-O; Belting M; Johnson RS
Article: NATURE COMMUNICATIONS. 2015;6:6340
The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia
Koh HS; Chang CY; Jeon S-B; Yoon HJ; Ahn Y-H; Kim H-S; Kim I-H; Jeon SH; Johnson RS; Park EJ
Article: FASEB JOURNAL. 2015;29(3):1102-1112
Suppression of erythropoiesis by dietary nitrate
Ashmore T; Fernandez BO; Evans CE; Huang Y; Branco-Price C; Griffin JL; Johnson RS; Feelisch M; Murray AJ
Journal article: JOURNAL OF HEPATOLOGY. 2015;:S0168-8278(15)00074-4
WITHDRAWN: Loss of hepatic HIF-1α accelerates lipid accumulation by inhibiting peroxisomal fatty acid oxidation in nonalcoholic fatty liver disease.
Arai T; Kato Y; Ishimoto K; Kanai M; Shinjo S; Sayama K; Suzuki T; Doi T; Johnson RS; Suematsu M; Goda N
Article: JOURNAL OF PHYSIOLOGY-LONDON. 2014;592(21):4715-4731
Dietary nitrate increases arginine availability and protects mitochondrial complex I and energetics in the hypoxic rat heart
Ashmore T; Fernandez BO; Branco-Price C; West JA; Cowburn AS; Heather LC; Griffin JL; Johnson RS; Feelisch M; Murray AJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(32):22459-22469
Hypoxia-inducible Factor-1α Induces ErbB4 Signaling in the Differentiating Mammary Gland
Paatero I; Seagroves TN; Vaparanta K; Han W; Jones FE; Johnson RS; Elenius K
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2014;307(3):R248-R255
Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism
Lindholm ME; Fischer H; Poellinger L; Johnson RS; Gustafsson T; Sundberg CJ; Rundqvist H
Article: DEVELOPMENTAL BIOLOGY. 2014;391(1):99-110
Gene-environment interaction demonstrates the vulnerability of the embryonic heart
O'Reilly VC; Floro KL; Shi H; Chapman BE; Preis JI; James AC; Chapman G; Harvey RP; Johnson RS; Grieve SM; Sparrow DB; Dunwoodie SL
Article: CELL. 2014;157(6):1339-1352
Increased Adipocyte O₂ Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity
Lee YS; Kim J-W; Osborne O; Oh DY; Sasik R; Schenk S; Chen A; Chung H; Murphy A; Watkins SM; Quehenberger O; Johnson RS; Olefsky JM
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134(3):801-808
Epidermal Deletion of HIF-2α Stimulates Wound Closure
Cowburn AS; Alexander LEC; Southwood M; Nizet V; Chilvers ER; Johnson RS
Article: BLOOD. 2014;123(3):366-376
Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish
Thompson AAR; Elks PM; Marriott HM; Eamsamarng S; Higgins KR; Lewis A; Williams L; Parmar S; Shaw G; McGrath EE; Formenti F; Van Eeden FJ; Kinnula VL; Pugh CW; Sabroe I; Dockrell DH; Chilvers ER; Robbins PA; Percy MJ; Simon MC; Johnson RS; Renshaw SA; Whyte MKB; Walmsley SR
Article: ONCOTARGET. 2013;4(12):2567-2576
Endothelial hypoxic metabolism in carcinogenesis and dissemination : HIF-A isoforms are a NO metastatic phenomenon
Branco-Price C; Evans CE; Johnson RS
Article: JOURNAL OF THE AMERICAN HEART ASSOCIATION. 2013;2(6):e000548
Activation of Hypoxia-Inducible Factor-2 in Adipocytes Results in Pathological Cardiac Hypertrophy
Lin Q; Huang Y; Booth CJ; Haase VH; Johnson RS; Simon MC; Giordano FJ; Yun Z
Journal article: THORAX. 2013;68:a140
HYPOXIA INDUCES HYPOTHERMIA AND SICKNESS BEHAVIOUR IN MICE FOLLOWING SUBCUTANEOUS INJECTION OF LIVE STAPHYLOCOCCUS AUREUS
Thompson AAR; Marriott HM; Williams L; Shaw G; Hameed A; Parmar S; Preston JA; Simon MC; Johnson RS; Foster SJ; Dockrell DH; Whyte MK; Walmsley SR
Journal article: CANCER PREVENTION RESEARCH. 2013;6(11_Supplement):a65
Abstract A65: Effect of voluntary running on metastasis in a mouse model of breast cancer
Rundqvist H; Mijwel S; Ahlstedt E; Lindholm C; Strell C; Roswall P; Pietras K; Johnson R; Ostman A
Article: NATURE IMMUNOLOGY. 2013;14(11):1173-1U99
Hypoxia-inducible factors enhance the effector responses of CD8⁺ T cells to persistent antigen
Doedens AL; Phan AT; Stradner MH; Fujimoto JK; Nguyen JV; Yang E; Johnson RS; Goldrath AW
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(43):17570-17575
HIF isoforms in the skin differentially regulate systemic arterial pressure
Cowburn AS; Takeda N; Boutin AT; Kim J-W; Sterling JC; Nakasaki M; Southwood M; Goldrath AW; Jamora C; Nizet V; Chilvers ER; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(41):16568-16573
HIF1α is required for osteoclast activation by estrogen deficiency in postmenopausal osteoporosis
Miyauchi Y; Sato Y; Kobayashi T; Yoshida S; Mori T; Kanagawa H; Katsuyama E; Fujie A; Hao W; Miyamoto K; Tando T; Morioka H; Matsumoto M; Chambon P; Johnson RS; Kato S; Toyama Y; Miyamoto T
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2013;91(10):1199-1205
HIF-1α influences myeloid cell antigen presentation and response to subcutaneous OVA vaccination
Bhandari T; Olson J; Johnson RS; Nizet V
Article: MICROCIRCULATION. 2013;20(5):385-393
Hypoxia-Inducible Factor-1 Is a Determinant of Lobular Structure and Oxygen Consumption in the Liver
Tsukada K; Tajima T; Hori S; Matsuura T; Johnson RS; Goda N; Suematsu M
Article: JOURNAL OF IMMUNOLOGY. 2013;191(1):407-414
Myeloid Hypoxia-Inducible Factor-1α Is Essential for Skeletal Muscle Regeneration in Mice
Scheerer N; Dehne N; Stockmann C; Swoboda S; Baba HA; Neugebauer A; Johnson RS; Fandrey J
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2013;91(5):637-644
Myeloid cell HIF-1α regulates asthma airway resistance and eosinophil function
Alexander LEC; Akong-Moore K; Feldstein S; Johansson P; Anh N; McEachern EK; Nicatia S; Cowburn AS; Olson J; Cho JY; Isaacs HJ; Johnson RS; Broide DH; Nizet V
Journal article: ATMOSPHERIC RESEARCH. 2013;122:469-485
Smoke aerosol transport patterns over the Maritime Continent
Xian P; Reid JS; Atwood SA; Johnson RS; Hyer EJ; Westphal DL; Sessions W
Article: CELL STEM CELL. 2013;12(1):49-61
Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells
Takubo K; Nagamatsu G; Kobayashi CI; Nakamura-Ishizu A; Kobayashi H; Ikeda E; Goda N; Rahimi Y; Johnson RS; Soga T; Hirao A; Suematsu M; Suda T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(43):17478-17483
Normal glucose uptake in the brain and heart requires an endothelial cell-specific HIF-1α-dependent function
Huang Y; Lei L; Liu D; Jovin I; Russell R; Johnson RS; Di Lorenzo A; Giordano FJ
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2012;90(9):1079-1089
A new pharmacological agent (AKB-4924) stabilizes hypoxia inducible factor-1 (HIF-1) and increases skin innate defenses against bacterial infection
Okumura CYM; Hollands A; Tran DN; Olson J; Dahesh S; von Koeckritz-Blickwede M; Thienphrapa W; Corle C; Jeung SN; Kotsakis A; Shalwitz RA; Johnson RS; Nizet V
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(35):14030-14034
microRNA-31/factor-inhibiting hypoxia-inducible factor 1 nexus regulates keratinocyte differentiation
Peng H; Kaplan N; Hamanaka RB; Katsnelson J; Blatt H; Yang W; Hao L; Bryar PJ; Johnson RS; Getsios S; Chandel NS; Lavker RM
Article: CANCER RESEARCH. 2012;72(13):3187-3195
Loss of Fibroblast HIF-1α Accelerates Tumorigenesis
Kim J-W; Evans C; Weidemann A; Takeda N; Lee YS; Stockmann C; Branco-Price C; Brandberg F; Leone G; Ostrowski MC; Johnson RS
Article: BLOOD. 2012;119(24):5931-5942
Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis
Meinecke A-K; Nagy N; Lago GD; Kirmse S; Klose R; Schroedter K; Zimmermann A; Helfrich I; Rundqvist H; Theegarten D; Anhenn O; Orian-Rousseau V; Johnson RS; Alitalo K; Fischer JW; Fandrey J; Stockmann C
Article: INTERNATIONAL JOURNAL OF HEMATOLOGY. 2012;95(5):471-477
HIF-mediated endothelial response during cancer progression
Evans CE; Branco-Price C; Johnson RS
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(5):1226-1236
Influence of hypoxia-inducible factor 1α on dendritic cell differentiation and migration
Koehler T; Reizis B; Johnson RS; Weighardt H; Foerster I
Article: JOURNAL OF HEPATOLOGY. 2012;56(2):441-447
HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice
Nishiyama Y; Goda N; Kanai M; Niwa D; Osanai K; Yamamoto Y; Senoo-Matsuda N; Johnson RS; Miura S; Kabe Y; Suematsu M
Article: CANCER CELL. 2012;21(1):52-65
Endothelial Cell HIF-1α and HIF-2α Differentially Regulate Metastatic Success
Branco-Price C; Zhang N; Schnelle M; Evans C; Katschinski DM; Liao D; Ellies L; Johnson RS
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;415(3):445-449
Disruption of HIF-1α in hepatocytes impairs glucose metabolism in diet-induced obesity mice
Ochiai D; Goda N; Hishiki T; Kanai M; Senoo-Matsuda N; Soga T; Johnson RS; Yoshimura Y; Suematsu M
Journal article: BLOOD. 2011;118(21):sci-38
Physiology of HIF Regulation of Erythropoiesis
Johnson RS
Article: JOURNAL OF CELL BIOLOGY. 2011;195(4):689-701
Astrocyte pVHL and HIF-α isoforms are required for embryonic-to-adult vascular transition in the eye
Kurihara T; Westenskow PD; Krohne TU; Aguilar E; Johnson RS; Friedlander M
Article: DIABETOLOGIA. 2011;54(6):1554-1566
Ischaemia-induced retinal neovascularisation and diabetic retinopathy in mice with conditional knockout of hypoxia-inducible factor-1 in retinal Muller cells
Lin M; Chen Y; Jin J; Hu Y; Zhou KK; Zhu M; Le Y-Z; Ge J; Johnson RS; Ma J-X
Article: JOURNAL OF CLINICAL INVESTIGATION. 2011;121(3):1053-1063
Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice
Walmsley SR; Chilvers ER; Thompson AA; Vaughan K; Marriott HM; Parker LC; Shaw G; Parmar S; Schneider M; Sabroe I; Dockrell DH; Milo M; Taylor CT; Johnson RS; Pugh CW; Ratcliffe PJ; Maxwell PH; Carmeliet P; Whyte MKB
Article: NATURE CELL BIOLOGY. 2010;12(10):1007-1013
O₂ regulates stem cells through Wnt/β-catenin signalling
Mazumdar J; O'Brien WT; Johnson RS; LaManna JC; Chavez JC; Klein PS; Simon MC
Article: CANCER RESEARCH. 2010;70(19):7465-7475
Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression
Doedens AL; Stockmann C; Rubinstein MP; Liao D; Zhang N; DeNardo DG; Coussens LM; Karin M; Goldrath AW; Johnson RS
Article: CELL STEM CELL. 2010;7(3):391-402
Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells
Takubo K; Goda N; Yamada W; Iriuchishima H; Ikeda E; Kubota Y; Shima H; Johnson RS; Hirao A; Suematsu M; Suda T
Article: GLIA. 2010;58(10):1177-1185
Astrocyte Hypoxic Response Is Essential for Pathological But Not Developmental Angiogenesis of the Retina
Weidemann A; Krohne TU; Aguilar E; Kurihara T; Takeda N; Dorrell MI; Simon MC; Haase VH; Friedlander M; Johnson RS
Article: PLOS ONE. 2010;5(7):e11863
Astrocyte-Derived Vascular Endothelial Growth Factor Stabilizes Vessels in the Developing Retinal Vasculature
Scott A; Powner MB; Gandhi P; Clarkin C; Gutmann DH; Johnson RS; Ferrara N; Fruttiger M
Article: CELL METABOLISM. 2010;11(5):364-378
The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
Zhang N; Fu Z; Linke S; Chicher J; Gorman JJ; Visk D; Haddad GG; Poellinger L; Peet DJ; Powell F; Johnson RS
Article: DEVELOPMENT. 2010;137(9):1563-1571
von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina
Kurihara T; Kubota Y; Ozawa Y; Takubo K; Noda K; Simon MC; Johnson RS; Suematsu M; Tsubota K; Ishida S; Goda N; Suda T; Okano H
Article: AMERICAN JOURNAL OF PATHOLOGY. 2010;176(5):2269-2282
VHL Deletion Impairs Mammary Alveologenesis but Is Not Sufficient for Mammary Tumorigenesis
Seagroves TN; Peacock DL; Liao D; Schwab LP; Krueger R; Handorf CR; Haase VH; Johnson RS
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(9):4329-4334
Loss of myeloid cell-derived vascular endothelial growth factor accelerates fibrosis
Stockmann C; Kerdiles Y; Nomaksteinsky M; Weidemann A; Takeda N; Doedens A; Torres-Collado AX; Iruela-Arispe L; Nizet V; Johnson RS
Article: GENES & DEVELOPMENT. 2010;24(5):491-501
Differential activation and antagonistic function of HIF-α isoforms in macrophages are essential for NO homeostasis
Takeda N; O'Dea EL; Doedens A; Kim J-W; Weidemann A; Stockmann C; Asagiri M; Simon MC; Hoffmann A; Johnson RS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(11):3373-3383
The glial cell response is an essential component of hypoxia-induced erythropoiesis in mice
Weidemann A; Kerdiles YM; Knaup KX; Rafie CA; Boutin AT; Stockmann C; Takeda N; Scadeng M; Shih AY; Haase VH; Simon MC; Kleinfeld D; Johnson RS
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;387(4):789-794
HIF-1α is necessary to support gluconeogenesis during liver regeneration
Tajima T; Goda N; Fujiki N; Hishiki T; Nishiyama Y; Senoo-Matsuda N; Shimazu M; Soga T; Yoshimura Y; Johnson RS; Suematsu M
Article: BLOOD. 2009;114(4):844-859
Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
Fang H-Y; Hughes R; Murdoch C; Coffelt SB; Biswas SK; Harris AL; Johnson RS; Imityaz HZ; Simon MC; Fredlund E; Greten FR; Rius J; Lewis CE
Article: EXPERIMENTAL EYE RESEARCH. 2009;88(2):270-276
The function of VEGF-A in lens development: Formation of the hyaloid capillary network and protection against transient nuclear cataracts
Garcia CM; Shui Y-B; Kamath M; DeVillar J; Johnson RS; Gerber H-P; Ferrara N; Robinson ML; Beebe DC
Article: NATURE. 2008;456(7223):814-U107
Deletion of vascular endothelial growth factor in myeloid cells accelerates tumorigenesis
Stockmann C; Doedens A; Weidemann A; Zhang N; Takeda N; Greenberg JI; Cheresh DA; Johnson RS
Article: NATURE. 2008;456(7223):809-U101
A role for VEGF as a negative regulator of pericyte function and vessel maturation
Greenberg JI; Shields DJ; Barillas SG; Acevedo LM; Murphy E; Huang J; Scheppke L; Stockmann C; Johnson RS; Angle N; Cheresh DA
Article: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2008;49(11):4961-4970
HIF-1: An Age-Dependent Regulator of Lens Cell Proliferation
Shui Y-B; Arbeit JM; Johnson RS; Beebe DC
Article: ONCOGENE. 2008;27(40):5354-5358
Hypoxia-inducible factor-2 regulates vascular tumorigenesis in mice
Rankin EB; Rha J; Unger TL; Wu CH; Shutt HP; Johnson RS; Simon MC; Keith B; Haase VH
Article: DEVELOPMENT. 2008;135(17):2939-2948
Cited2 is required for the proper formation of the hyaloid vasculature and for lens morphogenesis
Chen Y; Doughman Y-Q; Gu S; Jarrell A; Aota S-I; Cvekl A; Watanabe M; Dunwoodie SL; Johnson RS; van Heyningen V; Kleinjan DA; Beebe DC; Yang Y-C
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2008;128(8):1964-1968
Critical role of HIF-1α in keratinocyte defense against bacterial infection
Peyssonnaux C; Boutin AT; Zinkernagel AS; Datta V; Nizet V; Johnson RS
Article: NATURE. 2008;453(7196):807-8U9
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Rius J; Guma M; Schachtrup C; Akassoglou K; Zinkernagel AS; Nizet V; Johnson RS; Haddad GG; Karin M
Article: MOLECULAR AND CELLULAR BIOLOGY. 2008;28(11):3790-3803
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
Lei L; Mason S; Liu D; Huang Y; Marks C; Hickey R; Jovin IS; Pypaert M; Johnson RS; Giordano FJ
Article: CELL. 2008;133(2):223-234
Epidermal sensing of oxygen is essential for systemic hypoxic response
Boutin AT; Weidemann A; Fu Z; Mesropian L; Gradin K; Jamora C; Wiesener M; Eckardt K-U; Koch CJ; Ellies LG; Haddad G; Haase VH; Simon MC; Poellinger L; Powell FL; Johnson RS
Article: CANCER CELL. 2008;13(3):206-220
HIF1α induces the recruitment of bone marrow-derived vascular modulatory cells to regulate tumor angiogenesis and invasion
Du R; Lu KV; Petritsch C; Liu P; Ganss R; Passegue E; Song H; VandenBerg S; Johnson RS; Werb Z; Bergers G
Journal article: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2008;27(2):s191
360: Constantly Stable HIF-1α in Myeloid Cells Prevents Acute Rejection in Rat Cardiac Allografts
Keränen MAI; Tuuminen R; Nykänen AI; Tavast E; Koskinen PK; Johnson RS; Lemström KB
Article: JOURNAL OF INFECTIOUS DISEASES. 2008;197(2):214-217
Pharmacologic augmentation of hypoxia-inducible factor-1α with mimosine boosts the bactericidal capacity of phagocytes
Zinkernagel AS; Peyssonnaux C; Johnson RS; Nizet V
Article: CELL CYCLE. 2008;7(1):28-32
Role of the hypoxia inducible factors in iron metabolism
Peyssonnaux C; Nizet V; Johnson RS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(12):3810-3820
Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition
Higgins DF; Kimura K; Bernhardt WM; Shrimanker N; Akai Y; Hohenstein B; Saito Y; Johnson RS; Kretzler M; Cohen CD; Eckardt K-U; Iwano M; Haase VH
Article: DEVELOPMENT. 2007;134(21):3917-3928
HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis
Amarilio R; Viukov SV; Sharir A; Eshkar-Oren I; Johnson RS; Zelzer E
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2007;293(5):R2059-R2069
HIF-1α in endurance training:: suppression of oxidative metabolism
Mason SD; Rundqvist H; Papandreou I; Duh R; McNulty WJ; Howlett RA; Olfert IM; Sundberg CJ; Denko NC; Poellinger L; Johnson RS
Article: BLOOD. 2007;110(8):3039-3048
HIF-1 regulates heritable variation and allele expression phenotypes of the macrophage immune response gene SLC11A1 from a Z-DNA-forming microsatellite
Bayele HK; Peyssonnaux C; Giatromanolaki A; Arrais-Silva WW; Mohamed HS; Collins H; Giorgio S; Koukourakis M; Johnson RS; Blackwell JM; Nizet V; Srai SKS
Article: ONCOGENE. 2007;26(31):4531-4540
Loss of vascular endothelial growth factor expression reduces vascularization, but not growth, of tumors lacking the Von Hippel-Lindau tumor suppressor gene
Blouw B; Haase VH; Song H; Bergers G; Johnson RS
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(7):1926-1932
Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)
Peyssonnaux C; Zinkernagel AS; Schuepbach RA; Rankin E; Vaulont S; Haase VH; Nizet V; Johnson RS
Article: JOURNAL OF IMMUNOLOGY. 2007;178(12):7516-7519
Cutting edge:: Essential role of hypoxia inducible factor-1α in development of lipopolysaccharide-induced sepsis
Peyssonnaux C; Cejudo-Martin P; Doedens A; Zinkernagel AS; Johnson RS; Nizet V
Article: JOURNAL OF NEUROSCIENCE. 2007;27(23):6320-6332
Neuron-specific inactivation of the hypoxia inducible factor 1α increases brain injury in a mouse model of transient focal cerebral ischemia
Baranova O; Miranda LF; Pichiule P; Dragatsis I; Johnson RS; Chavez JC
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(6):1616-1626
The hypoxia-inducible factor a pathway couples angiogenesis to osteogenesis during skeletal development
Wang Y; Wan C; Deng L; Liu X; Cao X; Gilbert SR; Bouxsein ML; Faugere M-C; Guldberg RE; Gerstenfeld LC; Haase VH; Johnson RS; Schipani E; Clemens TL
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(22):16187-16201
In cultured astrocytes, p53 and MDM2 do not alter hypoxia-inducible factor-1α function regardless of the presence of DNA damage
Rempe DA; Lelli KM; Vangeison G; Johnson RS; Federoff HJ
Article: JOURNAL OF CELL BIOLOGY. 2007;177(3):451-464
Hif-1α regulates differentiation of limb bud mesenchyme and joint development
Provot S; Zinyk D; Gunes Y; Kathri R; Le Q; Kronenberg HM; Johnson RS; Longaker MT; Giaccia AJ; Schipani E
Article: JOURNAL OF CLINICAL INVESTIGATION. 2007;117(4):1068-1077
Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo
Rankin EB; Biju MP; Liu Q; Unger TL; Rha J; Johnson RS; Simon MC; Keith B; Haase VH
Article: MOLECULAR PHARMACOLOGY. 2007;71(3):942-948
ATP6V0C competes with von Hippel-Lindau protein in hypoxia-inducible factor 1α (HIF-1α) binding and mediates HIF-1α expression by bafilomycin A1
Lim J-H; Park J-W; Kim SJ; Kim M-S; Park S-K; Johnson RS; Chun Y-S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(7):2301-2306
Acute postnatal ablation of Hif-2α results in anemia
Gruber M; Hu C-J; Johnson RS; Brown EJ; Keith B; Simon MC
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2007;30(2):341-348
von Hippel Lindau tumor suppressor regulates hepatic glucose metabolism by controlling expression of glucose transporter 2 and glucose 6-phosphatase
Park S-K; Haase VH; Johnson RS
Article: CANCER RESEARCH. 2007;67(2):563-572
Hypoxia-inducible factor-1α is a key regulator of metastasis in a transgenic model of cancer initiation and progression
Liao D; Corle C; Seagroves TN; Johnson RS
Article: MOLECULAR PHARMACOLOGY. 2006;70(6):1856-1865
Bafilomycin induces the p21-mediated growth inhibition of cancer cells under hypoxic conditions by expressing hypoxia-inducible factor-1α
Lim J-H; Park J-W; Kim M-S; Park S-K; Johnson RS; Chun Y-S
Article: TISSUE ENGINEERING. 2006;12(11):3135-3147
In vitro liver tissue model established from transgenic mice:: Role of HIF-1alpha on hypoxic gene expression
Allen JW; Khetani SR; Johnson RS; Bhatia SN
Journal article: TISSUE ENGINEERING. 2006;0(0):061004065151004
In Vitro Liver Tissue Model Established from Transgenic Mice: Role of HIF1alpha on Hypoxic Gene Expression
Allen JW; Khetani SR; Johnson RS; Bhatia SN
Article: NATURE MEDICINE. 2006;12(7):793-800
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis
Tam BYY; Wei K; Rudge JS; Hoffman J; Holash J; Park S-K; Yuan J; Hefner C; Chartier C; Lee J-S; Jiang S; Niyak NR; Kuypers FA; Ma L; Sundram U; Wu G; Garcia JA; Schrier SL; Maher JJ; Johnson RS; Yancopoulos GD; Mulligan RC; Kuo CJ
Article: BLOOD. 2006;107(9):3727-3732
TLR4-dependent hepcidin expression by myeloid cells in response to bacterial pathogens
Peyssonnaux C; Zinkernagel AS; Datta V; Lauth X; Johnson RS; Nizet V
Article: MOLECULAR AND CELLULAR BIOLOGY. 2006;26(7):2519-2530
pVHL function is essential for endothelial extracellular matrix deposition
Tang N; Mack F; Haase VH; Simon MC; Johnson RS
Article: CELLULAR MICROBIOLOGY. 2006;8(2):339-352
The host cell transcription factor hypoxia-inducible factor 1 is required for Toxoplasma gondii growth and survival at physiological oxygen levels
Spear W; Chan D; Coppens I; Johnson RS; Giaccia A; Blader IJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(47):17071-17076
Hypoxia inducible factor 1α regulates T cell receptor signal transduction
Neumann AK; Yang J; Biju MP; Joseph SK; Johnson RS; Haase VH; Freedman BD; Turka LA
Article: JOURNAL OF CLINICAL INVESTIGATION. 2005;115(7):1806-1815
HIF-1α expression regulates the bactericidal capacity of phagocytes
Peyssonnaux C; Datta V; Cramer T; Doedens A; Theodorakis EA; Gallo RL; Hurtado-Ziola N; Nizet V; Johnson RS
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(12):5040-5051
DNA topoisomerase I is a cofactor for c-Jun in the regulation of epidermal growth factor receptor expression and cancer cell proliferation
Mialon A; Sankinen M; Söderström H; Junttila TT; Holmström T; Koivusalo R; Papageorgiou AC; Johnson RS; Hietanen S; Elenius K; Westermarck J
Article: JOURNAL OF NEUROSCIENCE. 2005;25(16):4099-4107
Brain-specific knock-out of hypoxia-inducible factor-1α reduces rather than increases hypoxic-ischemic damage
Helton R; Cui J; Scheel JR; Ellison JA; Ames C; Gibson C; Blouw B; Ouyang L; Dragatsis I; Zeitlin S; Johnson RS; Lipton SA; Barlow C
Article: MOLECULAR AND CELLULAR BIOLOGY. 2005;25(8):3163-3172
Inactivation of the arylhydrocarbon receptor nuclear translocator (Arnt) suppresses von Hippel-Lindau disease-associated vascular tumors in mice
Rankin EB; Higgins DF; Walisser JA; Johnson RS; Bradfield CA; Haase VH
Article: JOURNAL OF CELL BIOLOGY. 2005;168(6):911-920
Inhibition of NGF deprivation-induced death by low oxygen involves suppression of BIMEL and activation of HIF-1
Xie L; Johnson RS; Freeman RS
Article: TOXICOLOGY LETTERS. 2005;155(1):151-159
Hypoxic inhibition of 3-methylcholanthrene-induced CYP1A1 expression is independent of HIF-1 alpha
Allen JW; Johnson RS; Bhatia SN
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(1):105-115
Hypoxia-induced neutrophil survival is mediated by HIF-1α-dependent NF-κB activity
Walmsley SR; Print C; Farahi N; Peyssonnaux C; Johnson RS; Cramer T; Sobolewski A; Condliffe AM; Cowburn AS; Johnson N; Chilvers ER
Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2004;287(6):F1223-F1232
Hypoxic induction of Ctgf is directly mediated by Hif-1
Higgins DF; Biju MP; Akai Y; Wutz A; Johnson RS; Haase VH
Journal article: BLOOD. 2004;104(11):2163
Hypoxia-independent regulation of hepatic erythropoietin production by vascular endothelial growth factor.
Tam BYY; Hoffman J; Park SK; Lee JS; Sundram U; Wu G; Schrier SL; Johnson R; Mulligan R; Kuo CJ
Article: CANCER CELL. 2004;6(5):485-495
Loss of HIF-1α in endothelial cells disrupts a hypoxia-driven VEGF autocrine loop necessary for tumorigenesis
Tang N; Wang LC; Esko J; Giordano FJ; Huang Y; Gerber HP; Ferrara N; Johnson RS
Journal article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(8):1098-1106
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen J; Furuta GT; Tomaszewski JE; Johnson RS; Colgan SP; Haase VH
Article: JOURNAL OF CLINICAL INVESTIGATION. 2004;114(8):1098-1106
Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis
Karhausen J; Furuta GT; Tomaszewski JE; Johnson RS; Colgan SP; Haase VH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(40):14461-14466
A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation
Ogawa S; Lozach J; Jepsen K; Sawka-Verhelle D; Perissi V; Sasik R; Rose DW; Johnson RS; Rosenfeld MG; Glass CK
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(20):9038-9047
Vhlh gene deletion induces Hif-1-mediated cell death in thymocytes
Biju MP; Neumann AK; Bensinger SJ; Johnson RS; Turka LA; Haase VH
Article: PLOS BIOLOGY. 2004;2(10):1540-1548
Loss of skeletal muscle HIF-1α results in altered exercise endurance
Mason SD; Howlett RA; Kim MJ; Olfert IM; Hogan MC; McNulty W; Hickey RP; Wagner PD; Kahn CR; Giordano FJ; Johnson RS
Article: FASEB JOURNAL. 2004;18(7):1138-1140
Cardiac myocyte-specific HIF-1α deletion alters vascularization, energy availability, calcium flux, and contractility in the normoxic heart
Huang Y; Hickey RP; Yeh JL; Liu DG; Dadak A; Young LH; Johnson RS; Giordano FJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):23969-23976
The human CYP1A1 gene is regulated in a developmental and tissue-specific fashion in transgenic mice
Galijatovic A; Beaton D; Nguyen N; Chen SJ; Bonzo J; Johnson R; Maeda S; Karin M; Guengerich FP; Tukey RH
Article: OSTEOARTHRITIS AND CARTILAGE. 2004;12(6):433-439
Expression of VEGF isoforms by epiphyseal chondrocytes during low-oxygen tension is HIF-1α dependent
Cramer T; Schipani E; Johnson RS; Swoboda B; Pfander D
Article: DEVELOPMENT. 2004;131(10):2497-2508
Deletion of Vhlh in chondrocytes reduces cell proliferation and increases matrix deposition during growth plate development
Pfander D; Kobayashi T; Knight MC; Zelzer E; Chan DA; Olsen BR; Giaccia AJ; Johnson RS; Haase VH; Schipani E
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(10):4128-4137
Glucose utilization is essential for hypoxia-inducible factor 1α-dependent phosphorylation of c-jun
Laderoute KR; Calaoagan JM; Knapp M; Johnson RS
Article: DEVELOPMENT. 2004;131(9):2161-2171
VEGFA is necessary for chondrocyte survival during bone development
Zelzer E; Mamluk R; Ferrara N; Johnson RS; Schipani E; Olsen BR
Article: CELL CYCLE. 2004;3(2):168-171
An unexpected role for hypoxic response - Oxygenation and inflammation
Peyssonnaux C; Johnson RS
Article: CANCER CELL. 2003;4(2):133-146
The hypoxic response of tumors is dependent on their microenvironment
Blouw B; Song HQ; Tihan T; Bosze J; Ferrara N; Gerber HP; Johnson RS; Bergers G
Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(14):4959-4971
Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1α (HIF-1α):: Role of cytoplasmic trapping of HIF-2α
Park SK; Dadak AM; Haase VH; Fontana L; Giaccia AJ; Johnson RS
Article: DEVELOPMENTAL CELL. 2003;4(6):865-877
c-Jun is essential for organization of the epidermal leading edge
Li GC; Gustafson-Brown C; Hanks SK; Nason K; Arbeit JM; Pogliano K; Wisdom RM; Johnson RS
Article: CELL CYCLE. 2003;2(3):192-193
A Novel Role for the Hypoxia Inducible Transcription Factor HIF-1α Critical Regulation of Inflammatory Cell Function
Cramer T; Johnson RS
Article: ONCOGENE. 2003;22(21):3213-3220
The hypoxia-inducible factor-1α is a negative factor for tumor therapy
Unruh A; Ressel A; Mohamed HG; Johnson RS; Nadrowitz R; Richter E; Katschinski DM; Wenger RH
Journal article: CELL. 2003;113(3):419
HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation
Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(9):3265-3273
Decreased expression of the DNA mismatch repair gene Mlh1 under hypoxic stress in mammalian cells
Mihaylova VT; Bindra RS; Yuan JL; Campisi D; Narayanan L; Jensen R; Giordano F; Johnson RS; Rockwell S; Glazer PM
Article: JOURNAL OF CELL SCIENCE. 2003;116(9):1819-1826
HIF-1α controls extracellular matrix synthesis by epiphyseal chondrocytes
Pfander D; Cramer T; Schipan E; Johnson RS
Article: DEVELOPMENT. 2003;130(8):1713-1724
HIF1α a is a critical regulator of secretory differentiation and activation, but not vascular expansion, in the mouse mammary gland
Seagroves TN; Hadsell D; McManaman J; Palmer C; Liao D; McNulty W; Welm B; Wagner KU; Neville M; Johnson RS
Article: CELL. 2003;112(5):645-657
HIF-1α is essential for myeloid cell-mediated inflammation
Cramer T; Yamanishi Y; Clausen BE; Förster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS
Journal article: HEPATOLOGY. 2003;38:270
235 Oxygen modulation of cytochrome P450 pathways: role of oxygen gradients and HIF-1alpha in hepatocytes in vitro
Allen JW; Johnson RS; Bhatia SN
Article: GENE EXPRESSION. 2003;11(3-4):181-197
Gene expression profiling of the hypoxia signaling pathway in hypoxia-inducible factor 1α null mouse embryonic fibroblasts
Vengellur A; Woods BG; Ryan HE; Johnson RS; LaPres JJ
Article: MOLECULAR AND CELLULAR BIOLOGY. 2003;23(1):359-369
Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia
Goda N; Ryan HE; Khadivi B; McNulty W; Rickert RC; Johnson RS
Article: DEVELOPMENTAL CELL. 2002;3(3):351-365
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
Putkey FR; Cramer T; Morphew MK; Silk AD; Johnson RS; McIntosh JR; Cleveland DW
Article: JOURNAL OF CELL BIOLOGY. 2002;158(3):453-461
c-jun is essential for sympathetic neuronal death induced by NGF withdrawal but not by p75 activation
Palmada M; Kanwal S; Rutkoski NJ; Gufstafson-Brown C; Johnson RS; Wisdom R; Carter BD
Article: MOLECULAR AND CELLULAR BIOLOGY. 2002;22(8):2515-2523
The response of c-Jun/AP-1 to chronic hypoxia is hypoxia-inducible factor 1α dependent
Laderoute KR; Calaoagan JM; Gustafson-Brown C; Knapp AM; Li GC; Mendonca HL; Ryan HE; Wang ZH; Johnson RS
Article: DEVELOPMENTAL CELL. 2002;2(3):331-341
Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13:: A mechanism for regulation of adipogenesis by hypoxia
Yun Z; Maecker HL; Johnson RS; Giaccia AJ
Article: FASEB JOURNAL. 2002;16(1):411-413
Physiologically low oxygen concentrations determined in fetal skin regulate hypoxia-inducible factor 1 and transforming growth factor β3
Scheid A; Wenger RH; Schäffer L; Camenisch I; Distler O; Ferenc A; Cristina H; Ryan HE; Johnson RS; Wagner KF; Stauffer UG; Bauer C; Gassmann M; Meuli M
Article: CANCER JOURNAL. 2002;8(1):47-54
Vascular endothelial growth factor enhances endothelial cell survival and tumor radioresistance
Gupta VK; Jaskowiak NT; Beckett MA; Mauceri HJ; Grunstein J; Johnson RS; Calvin DA; Nodzenski E; Pejovic M; Kufe DW; Posner MC; Weichselbaum RR
Article: CELL. 2001;107(6):763-775
IKKα provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development
Cao YX; Bonizzi G; Seagroves TN; Greten FR; Johnson R; Schmidt EV; Karin M
Article: GENES & DEVELOPMENT. 2001;15(21):2865-2876
Hypoxia in cartilage:: HIF-1α is essential for chondrocyte growth arrest and survival
Schipani E; Ryan HE; Didrickson S; Kobayashi T; Knight M; Johnson RS
Article: GENES & DEVELOPMENT. 2001;15(19):2520-2532
Induction of hypervascularity without leakage or inflammation in transgenic mice overexpressing hypoxia-inducible factor-1α
Elson DA; Thurston G; Huang LE; Ginzinger DG; McDonald DM; Johnson RS; Arbeit JM
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;284(5):1134-1139
c-jun cooperates with SV40 T-antigen to sustain MMP-2 expression in immortalized cells
Laderoute KR; Calaoagan JM; Knapp AM; Mendonca HL; Johnson RS
Article: GENES & DEVELOPMENT. 2001;15(11):1435-1448
Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium
Mohanty S; Lee S; Yadava N; Dealy MJ; Johnson RS; Firtel RA
Article: MOLECULAR AND CELLULAR BIOLOGY. 2001;21(10):3436-3444
Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
Seagroves TN; Ryan HE; Lu H; Wouters BG; Knapp M; Thibault P; Laderoute K; Johnson RS
Article: CANCER RESEARCH. 2000;60(21):6189-6195
Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
Elson DA; Ryan HE; Snow JW; Johnson R; Arbeit JM
Article: MOLECULAR AND CELLULAR BIOLOGY. 2000;20(19):7282-7291
Isoforms of vascular endothelial growth factor act in a coordinate fashion to recruit and expand tumor vasculature
Grunstein J; Masbad JJ; Hickey R; Giordano F; Johnson RS
Journal article: IMMUNOPHARMACOLOGY. 2000;49(1-2):80
Activation of the alternative complement pathway in factor D-deficient mice
Xu Y; Ma M; Ippolito GC; Johnson RS; Szalai AJ; Spiegelman BM; Schroeder HW; Carroll MC; Volanakis JE
Article: CANCER RESEARCH. 2000;60(15):4010-4015
Hypoxia-inducible factor-1α is a positive factor in solid tumor growth
Ryan HE; Poloni M; McNulty W; Elson D; Gassmann M; Arbeit JM; Johnson RS
Article: CELL. 2000;102(2):221-231
Requirement for p38α in erythropoietin expression:: A role for stress kinases in erythropoiesis
Tamura K; Sudo T; Senftleben U; Dadak AM; Johnson R; Karin M
Journal article: MOLECULAR ENDOCRINOLOGY. 2000;14(6):848-862
Hypoxia-Inducible Factor-1 (HIF-1) Up-Regulates Adrenomedullin Expression in Human Tumor Cell Lines during Oxygen Deprivation: A Possible Promotion Mechanism of Carcinogenesis
Garayoa M
Article: MOLECULAR CELL. 2000;5(6):969-979
Female mice heterozygous for IKKγ/NEMO deficiencies develop a dermatopathy similar to the human X-linked disorder incontinentia pigmenti
Makris C; Godfrey VL; Krähn-Senftleben G; Takahashi T; Roberts JL; Schwarz T; Feng LL; Johnson RS; Karin M
Article: MOLECULAR ENDOCRINOLOGY. 2000;14(6):848-862
Hypoxia-inducible factor-1 (HIF-1) up-regulates adrenomedullin expression in human tumor cell lines during oxygen deprivation: A possible promotion mechanism of carcinogenesis
Garayoa M; Martínez A; Lee SM; Pío R; An WG; Neckers L; Trepel J; Montuenga LM; Ryan H; Johnson R; Gassmann M; Cuttitta F
Article: GENES & DEVELOPMENT. 2000;14(4):391-396
Loss of PTEN facilitates HIF-1-mediated gene expression
Zundel W; Schindler C; Haas-Kogan D; Koong A; Kaper F; Chen E; Gottschalk AR; Ryan HE; Johnson RS; Jefferson AB; Stokoe D; Giaccia AJ
Article: IMMUNITY. 2000;12(1):17-26
Thymocyte selection is regulated by the helix-loop-helix inhibitor protein, Id3
Rivera RR; Johns CP; Quan J; Johnson RS; Murre C
Journal article: CANCER RESEARCH. 2000;60(1):38-41
Carcinogenic nickel induces genes involved with hypoxic stress
Salnikow K; Blagosklonny MV; Ryan H; Johnson R; Costa M
Article: NATURE GENETICS. 1999;23(2):245-248
Loss of Cul1 results in early embryonic lethality and dysregulation of cyclin E
Dealy MJ; Nguyen KVT; Lo J; Gstaiger M; Krek W; Elson D; Arbeit J; Kipreos ET; Johnson RS
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 1999;189(11):1839-1845
The IKKβ subunit of IκB kinase (IKK) is essential for nuclear factor κB activation and prevention of apoptosis
Li ZW; Chu WM; Hu YL; Delhase M; Deerinck T; Ellisman M; Johnson R; Karin M
Article: SCIENCE. 1999;284(5412):316-320
Abnormal morphogenesis but intact IKK activation in mice lacking the IKKα subunit of IκB kinase
Hu YL; Baud V; Delhase M; Zhang PL; Deerinck T; Ellisman M; Johnson R; Karin M
Journal article: CANCER RESEARCH. 1999;59(7):1592-1598
Tumor-derived expression of vascular endothelial growth factor is a critical factor in tumor expansion and vascular function
Grunstein J; Roberts WG; Mathieu-Costello O; Hanahan D; Randall S
Article: EMBO JOURNAL. 1999;18(1):188-197
c-Jun regulates cell cycle progression and apoptosis by distinct mechanisms
Wisdom R; Johnson RS; Moore C
Article: EMBO JOURNAL. 1998;17(11):3005-3015
HIF-1α is required for solid tumor formation and embryonic vascularization
Ryan HE; Lo J; Johnson RS
Journal article: JOURNAL OF HORTICULTURAL SCIENCE & BIOTECHNOLOGY. 1998;73(6):856-861
The effect of timing of post-harvest foliar urea sprays on nitrogen absorption and partitioning in peach and nectarine trees
Rosecrance RC; Johnson RS; Weinbaum SA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1997;94(25):14060-14065
Epilepsy in mice deficient in the 65-kDa isoform of glutamic acid decarboxylase
Kash SF; Johnson RS; Tecott LH; Noebels JL; Mayfield RD; Hanahan D; Baekkeskov S
Article: SCIENCE. 1996;274(5291):1377-1379
Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein
Hotamisligil GS; Johnson RS; Distel RJ; Ellis R; Papaioannou VE; Spiegelman BM
Journal article: MOLECULAR AND CELLULAR BIOLOGY. 1996;16(8):4504-4511
Cellular transformation and malignancy induced by ras require c-jun
Johnson R; Spiegelman B; Hanahan D; Wisdom R
Article: JOURNAL OF NEUROSCIENCE. 1996;16(12):3827-3836
Null mutation of c-fos impairs structural and functional plasticities in the kindling model of epilepsy
Watanabe Y; Johnson RS; Butler LS; Binder DK; Spiegelman BM; Papaioannou VE; McNamara JO
Article: JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY. 1996;178(4):563-570
The circadian system of c-fos deficient mice
Honrado GI; Johnson RS; Golombek DA; Spiegelman BM; Papaioannou VE; Ralph MR
Journal article: EMBO JOURNAL. 1995;14(10):2217-2228
A TRANSITION IN TRANSCRIPTIONAL ACTIVATION BY THE GLUCOCORTICOID AND RETINOIC ACID RECEPTORS AT THE TUMOR STAGE OF DERMAL FIBROSARCOMA DEVELOPMENT
VIVANCO MD; JOHNSON R; GALANTE PE; HANAHAN D; YAMAMOTO KR
Journal article: NATURE. 1994;372(6507):710
Erratum: Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
Araki E; Lipes MA; Patti M-E; Claus Brüning J; Haag B; Johnson RS; Ronald Kahn C
Journal article: NATURE. 1994;372(6502):186-190
ALTERNATIVE PATHWAY OF INSULIN SIGNALING IN MICE WITH TARGETED DISRUPTION OF THE IRS-1 GENE
ARAKI E; LIPES MA; PATTI ME; BRUNING JC; HAAG B; JOHNSON RS; KAHN CR
Journal article: BRAIN RESEARCH. 1994;651(1-2):275-282
BEHAVIORAL-ASSESSMENT OF C-FOS MUTANT MICE
PAYLOR R; JOHNSON RS; PAPAIOANNOU V; SPIEGELMAN BM; WEHNER JM
Journal article: EMBO JOURNAL. 1994;13(13):3094-3103
TARGETED DISRUPTION OF THE C-FOS GENE DEMONSTRATES C-FOS-DEPENDENT AND C-FOS-INDEPENDENT PATHWAYS FOR GENE-EXPRESSION STIMULATED BY GROWTH-FACTORS OR ONCOGENES
HU ED; MUELLER E; OLIVIERO S; PAPAIOANNOU VE; JOHNSON R; SPIEGELMAN BM
Journal article: BIOLOGY OF REPRODUCTION. 1994;50(5):1040-1048
EFFECT OF A NULL MUTATION OF THE C-FOS PROTOONCOGENE ON SEXUAL-BEHAVIOR OF MALE-MICE
BAUM MJ; BROWN JJG; KICA E; RUBIN BS; JOHNSON RS; PAPAIOANNOU VE
Journal article: MOLECULAR AND CELLULAR BIOLOGY. 1994;14(3):1566-1574
Normal Peripheral T-Cell Function in c-Fos-Deficient Mice
Jain J; Nalefski EA; Mccaffrey PG; Johnson RS; Spiegelman BM; Papaioannou V; Rao A
Journal article: MOLECULAR AND CELLULAR BIOLOGY. 1994;14(3):1566-1574
NORMAL PERIPHERAL T-CELL FUNCTION IN C-FOS-DEFICIENT MICE
JAIN JN; NALEFSKI EA; MCCAFFREY PG; JOHNSON RS; SPIEGELMAN BM; PAPAIOANNOU V; RAO A
Journal article: JOURNAL OF IMMUNOLOGY. 1993;151(3):1528-1534
TARGETED DISRUPTION OF CD43 GENE ENHANCES T-LYMPHOCYTE ADHESION
MANJUNATH N; JOHNSON RS; STAUNTON DE; PASQUALINI R; ARDMAN B
Journal article: GENES & DEVELOPMENT. 1993;7(7B):1309-1317
A NULL MUTATION AT THE C-JUN LOCUS CAUSES EMBRYONIC LETHALITY AND RETARDED CELL-GROWTH IN CULTURE
JOHNSON RS; VANLINGEN B; PAPAIOANNOU VE; SPIEGELMAN BM
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1993;90(9):3913-3917
MICE LACKING MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I AND CLASS-II MOLECULES
GRUSBY MJ; AUCHINCLOSS H; LEE R; JOHNSON RS; SPENCER JP; ZIJLSTRA M; JAENISCH R; PAPAIOANNOU VE; GLIMCHER LH
Journal article: CELL. 1992;71(4):577-586
PLEIOTROPIC EFFECTS OF A NULL MUTATION IN THE C-FOS PROTOONCOGENE
JOHNSON RS; SPIEGELMAN BM; PAPAIOANNOU V
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1992;89(19):9306-9310
GROWTH AND DIFFERENTIATION OF EMBRYONIC STEM-CELLS THAT LACK AN INTACT C-FOS GENE
FIELD SJ; JOHNSON RS; MORTENSEN RM; PAPAIOANNOU VE; SPIEGELMAN BM; GREENBERG ME
Journal article: CELL. 1992;68(5):869-877
RAG-1-DEFICIENT MICE HAVE NO MATURE LYMPHOCYTES-B AND LYMPHOCYTES-T
MOMBAERTS P; IACOMINI J; JOHNSON RS; HERRUP K; TONEGAWA S; PAPAIOANNOU VE
Journal article: SCIENCE. 1991;253(5026):1417-1420
DEPLETION OF CD4+ T-CELLS IN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II DEFICIENT MICE
GRUSBY MJ; JOHNSON RS; PAPAIOANNOU VE; GLIMCHER LH
Journal article: SCIENCE. 1989;245(4923):1234-1236
TARGETING OF NONEXPRESSED GENES IN EMBRYONIC STEM-CELLS VIA HOMOLOGOUS RECOMBINATION
JOHNSON RS; SHENG M; GREENBERG ME; KOLODNER RD; PAPAIOANNOU VE; SPIEGELMAN BM
Journal article: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY. 1987;45(7):608-612
DIAGNOSIS AND TREATMENT OF VONWILLEBRANDS DISEASE
JOHNSON RS; HELDT LV; KEATON WM
Journal article: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY. 1987;45(6):533-536
MANAGEMENT OF A RUPTURED PSEUDOANEURYSM OF THE SPHENOPALATINE ARTERY FOLLOWING A LE-FORT-I OSTEOTOMY
HEMMIG SB; JOHNSON RS; FERRARO N
Journal article: JOURNAL OF EXPERIMENTAL MEDICINE. 1985;162(4):1193-1207
HLA CLASS-II REGULATION AND STRUCTURE - ANALYSIS WITH HLA-DR3 AND HLA-DP POINT MUTANTS
PIOUS D; DIXON L; LEVINE F; COTNER T; JOHNSON R
Journal article: FERTILITY AND STERILITY. 1984;42(4):526-530
STERILIZATION FAILURES WITH BIPOLAR TUBAL CAUTERY
AYERS JWT; JOHNSON RS; ANSBACHER R; MENON M; LAFERLA JJ; ROBERTS JA
Journal article: JOURNAL OF PROSTHETIC DENTISTRY. 1983;49(2):207-209
A CAST DOWEL-CORE TECHNIQUE FOR MULTIROOTED TEETH WITH DIVERGENT CANALS
ZIEBERT GJ; JOHNSON RS
Journal article: STATE GOVERNMENT. 1975;48(4):226-231
STATE INVESTMENT PORTFOLIO - CASE FOR CERTIFICATES OF DEPOSIT
HACKBART MM; JOHNSON RS
Journal article: MEDICAL LABORATORY TECHNOLOGY. 1974;31(4):299-303
IMPROVED BLOOD CULTURE MEDIUM
COETZEE EFC; JOHNSON RSA
Journal article: BMJ-BRITISH MEDICAL JOURNAL. 1961;1(523):1369-&
FATAL APLASTIC ANAEMIA AFTER TREATMENT OF THYROTOXICOSIS WITH POTASSIUM PERCHLORATE
JOHNSON RS; MOORE WG
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Preprint: BIORXIV. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Preprint: BIORXIV. 2022
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha P; Minogue E; Krause L; Hess R; Bargiela D; Wadsworth B; Barbieri L; Brombach C; Foskolou I; Bogeski I; Veliça P; Johnson R
Preprint: BIORXIV. 2022
Glutarate regulates T cell function and metabolism
Minogue E; Cunha P; Quaranta A; Zurita J; Teli SS; Wadsworth B; Hughes R; Grice G; Velica P; Bargiela D; Barbieri L; Wheelock C; Nathan J; Koivunen P; Foskolou I; Johnson R
Preprint: BIORXIV. 2022
The two enantiomers of 2-hydroxyglutarate differentially regulate cytotoxic T cell function
Foskolou I; Cunha P; Minogue E; Nicolet B; Guislain A; Jorgensen C; Zandhuis N; Barbieri L; Bargiela D; Nathanael D; Tyrakis P; Palazon A; Wolkers M; Johnson R
Conference publication: ACTA PHYSIOLOGICA. 2022;236:25
Tissue-specific vascular metabolism: role in metastasis
Reiterer M; Mc Erlain T; Eakin A; Johnson R; Branco C
Preprint: BIORXIV. 2021
Lactate regulation of activation in CD8+ T cells
Barbieri L; Veliça P; Gameiro P; Cunha P; Foskolou I; Bargiela D; Rundqvist H; Johnson R
Review: FEBS JOURNAL. 2021;288(24):7143-7161
Oxygen regulation of TET enzymes
Matuleviciute R; Cunha PP; Johnson RS; Foskolou IP
Preprint: RESEARCH SQUARE. 2021
Metabolic turnover and dynamics of RNA modifications by 13C labelling
Gameiro P; Foskolou I; Encheva V; Santos MSD; MacRae J; Johnson R; Ule J
Preprint: RESEARCH SQUARE. 2021
Metabolic turnover and dynamics of RNA modifications by 13C labelling
Gameiro PA; Foskolou I; Encheva V; Santos MSD; MacRae J; Johnson R; Ule J
Editorial comment: ACTA PHYSIOLOGICA. 2021;231(1):e13494
Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE) Response
Gojkovic M; Velica P; Rundqvist H; Johnson RS
Preprint: BIORXIV. 2020
MICROVASCULAR ENDOTHELIAL CELL ADAPTATION TO HYPOXIA IS ORGAN-SPECIFIC AND CONDITIONED BY ENVIRONMENTAL OXYGEN
Reiterer M; Eakin A; Burke A; Johnson R; Branco C
Preprint: BIORXIV. 2020
Modified Hypoxia Inducible Factor expression in CD8+ T cells increases anti-tumor efficacy
Veliça P; Cunha PP; Vojnovic N; Foskolou IP; Bargiela D; Gojkovic M; Rundqvist H; Johnson RS
Corrigendum: SCIENTIFIC REPORTS. 2020;10(1):1627
Acute and chronic hypoxia differentially predispose lungs for metastases (vol 9, 10246, 2019)
Reiterer M; Colaco R; Emrouznejad P; Jensen A; Rundqvist H; Johnson RS; Branco C
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):336
Cd8+T-cell Depletion Abolishes The Anti-metastatic Effects Of Voluntary Running In A Mouse Model Of Breast Cancer
Rundqvist H; Barbieri L; Velica P; Mijwel S; Ostman A; Johnson R
Preprint: BIORXIV. 2019
Lactate potentiates differentiation and expansion of cytotoxic T cells
Rundqvist H; Veliça P; Barbieri L; Gameiro P; Cunha P; Gojkovic M; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Pérez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson R
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Lactate Potentiates Differentiation and Expansion of Cytotoxic T Cells
Rundqvist H; Velica P; Barbieri L; Gameiro P; Cunha PP; Gojkovic M; Bargiela D; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Perez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson RS
Conference publication: BLOOD. 2018;132:3842
Aging of Bone Marrow Microenvironment Promotes Myeloid Bias of Hematopoietic Progenitors and Is a Target in Age-Related Myeloproliferative Neoplasms
Ho Y-H; del Toro R; Rivera-Torres J; Rak J; Korn C; Garcia-Garcia A; Kubovcakova L; Macias D; Arranz L; Gonzalez-Gomez C; Wittner M; Nienhold R; Waller AK; Foster HR; Lopez-Otin C; Johnson RS; Nerlov C; Vainchenker W; Ghevaert C; Louache F; Skoda RC; Andres V; Mendez-Ferrer S
Letter: NATURE. 2018;561(7724):E33-E40
The role of Olfr78 in the breathing circuit of mice
Torres-Torrelo H; Ortega-Saenz P; Macias D; Omura M; Zhou T; Matsunami H; Johnson RS; Mombaerts P; Lopez-Barneo J
Corrigendum: ELIFE. 2018;7:e38781
HIF-2α is essential for carotid body development and function (vol 7, e34681, 2018)
Macias D; Cowburn AS; Torres-Torrelo H; Ortega-Saenz P; Lopez-Barneo J; Johnson R
Preprint: BIORXIV. 2018
HIF-2α is essential for carotid body development and function
Macías D; Cowburn A; Torres-Torrelo H; Ortega-Sáenz P; López-Barneo J; S. Johnson R
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2018;48:44-45
Perivascular macrophages regulate blood flow following tissue damage
Vagesjo E; Seignez C; Christoffersson G; Herrera-Hidalgo C; Giraud A; Korsgren O; Rundqvist H; Essand M; Holm L; Johnson R; Phillipson M
Conference publication: CANCER SCIENCE. 2018;109:1161
Distinct roles of VEGF isoforms as negative regulator of extracellular matrix deposition for tumor progression
Yamamoto H; Stockmann C; Johnson RS
Conference publication: THORAX. 2017;72:A67-A68
HIF2A DELETION IN THE PULMONARY ENDOTHELIUM PREVENTS HYPOXIA-INDUCED PULMONARY HYPERTENSION
Cowburn AS; Crosby A; Macias-Gutierrez D; Southwood M; Branco C; Morrell N; Chilvers ER; Johnson RS
Other: EXPERIMENTAL CELL RESEARCH. 2017;356(2):115
Lorenz Poellinger
Giaccia A; Johnson RS
Conference publication: CANCER RESEARCH. 2017;77:pd8-05-pd8-05
Comparative analysis of the genomic landscape of breast cancers from women of African and European ancestry
Olopade OI; Pitt JJ; Riester M; Odetunde A; Yoshimatsu T; Labrot E; Ademola A; Sanni A; Okedere B; Mahan S; Nwosu I; Leary R; Ajani M; Johnson RS; Sveen E; Zheng Y; Wang S; Fitzgerald DJ; Grundstad J; Tuteja J; Clayton W; Khramtsova G; Oludara M; Omodele F; Benson O; Adeoye A; Morhason-Bello O; Ogundiran T; Babalola C; Popoola A; Morrissey M; Chen L; Huo D; Falusi A; Winckler W; Obafunwa J; Papoutsakis D; Ojengbede O; White KP; Ibrahim N; Oluwasola O; Barretina J
Conference publication: CYTOKINE. 2017;100:190
Glial galectin-9 plays anovel role inhypoxic tumor environment
Change CY; Baek S; Kim H-S; Jeon S-B; Johnson RS; Park EJ
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):256-257
They activated CD8+T-cells in low oxygen. What happens next will blow your mind!
Velica P; Rundqvist H; Gojkovic M; Johnson RS
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):309
Myeloid hypoxia leads to reduced metastatic success
Gojkovic M; Velica P; Darmasaputra G; Rundqvist H; Johnson R
Conference publication: ACTA PHYSIOLOGICA. 2017;219:43
No local or systemic effects of cutaneous exposure to hypobaric hypoxia in humans
Siebenmann C; Keramidas M; Rundqvist H; Mijwel S; Cowburn A; Johnson R; Eiken O
Editorial comment: CANCER CELL. 2016;30(6):831
To PFKFB3 or Not to PFKFB3, That Is the Question
Branco C; Johnson RS
Other: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(49):13938-13940
Profile of William Kaelin, Peter Ratcliffe, and Greg Semenza, 2016 Albert Lasker Basic Medical Research Awardees Fire in the air, fire in the cell
Johnson RS
Conference publication: THORAX. 2016;71:A61-A62
HYPOXIA PRECONDITIONS THE INNATE IMMUNE RESPONSE TO ACUTE BACTERIAL PULMONARY INFECTIONS
Dickinson RS; Thompson AAR; Thomson JP; Murphy F; Marriott HM; Tavares A; Willson J; Williams L; Lewis A; Forbes S; Stimson RH; Hameed AG; Preston JA; Lawrie A; Finisguerra V; Mazzone M; Foster SJ; Chilvers ER; Cowburn AS; Dockrell DH; Johnson RS; Meehan RR; Whyte MKB; Walmsley SR
Conference publication: CANCER RESEARCH. 2016;76:c10
The role of FIH in macrophage function
Gojkovic M; Rundqvist H; Velica P; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:a12
The immune composition of a spontaneous mouse breast cancer
Velica P; Rundqvist H; Gojkovic M; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:836
Effect of voluntary running on metastasis in a mouse model of breast cancer
Mijwel S; Rundqvist H; Lindholm C; Strell C; Roswall P; Pietras K; Johnson RS; Ostman A
Conference publication: CANCER RESEARCH. 2016;76:a21
Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa
Branco C; Rundqvist H; Colaco R; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:a19
Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors
Evans CE; Palazon A; Sim J; Tyrakis PA; Bendahl P-O; Belting M; Rundqvist H; Branco C; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:pr03
Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa
Branco C; Rundqvist H; Colaco R; Johnson RS
Corrigendum: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3):djv434
Erratum.
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2016;193
Hif2α Deletion In The Pulmonary Endothelial Prevents Hypoxia-Induced Pulmonary Hypertension
Cowburn AS; Crosby A; Macias-Gutierrez D; Southwood M; Crotty-Alexander L; Morrell NW; Chilvers ER; Johnson RS; Johnson RS
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2016;25(1):11-15
Cutaneous control of blood pressure
Johnson RS; Titze J; Weller R
Conference publication: BREAST CANCER RESEARCH AND TREATMENT. 2016;159(1):195
Endothelial HIF-a modulate cancer metastatic potential by affecting vascular permeability and pro-metastatic macrophage infiltration
Branco C; Evans C; Colaco R; Rundqvist H; Johnson R
Editorial comment: CANCER DISCOVERY. 2015;5(6):584-585
Through a Clear Cell, Darkly: HIF2α/PLIN2-Maintained Fat Droplets Protect ccRCCs from ER Stress
Sim J; Johnson RS
Conference publication: CANCER RESEARCH. 2015;75(1):b12
Molecular mechanisms of HIF-1a and HIF-2a activation in nonmalignant cells at the premetastatic niche: Effects on metastatic success
Branco-Price C; Palazon A; Xie J; Johnson RS
Conference publication: CLINICAL & EXPERIMENTAL METASTASIS. 2015;32(3):234-235
Myeloid cell derived vascular endothelial growth factor promotes pulmonary metastasis by increasing endothelial permeability
Rundqvist H; Stockmann C; Ponte R; Doedens A; Johnson RS
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2015;10(9):S394-S395
Microthrombosis Enhances Extravasation via Myeloid HypoxiaInducible Factors
Evans CE; Prodger A; Branco-Price C; Palazon A; Tyrakis P; Sim J; Rundqvist H; Bendahl P-O; Belting M; Johnson RS
Review: IMMUNITY. 2014;41(4):518-528
HIF Transcription Factors, Inflammation, and Immunity
Palazon A; Goldrath AW; Nizet V; Johnson RS
Editorial comment: DEVELOPMENTAL CELL. 2014;30(2):116-117
A Whiter Shade of Gray: HIF and Coordination of Angiogenesis with Postnatal Myelination
Sim J; Johnson RS
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2014;189
Hypoxia Inducible Factor (hif)-2α In Myeloid Cells Promotes Allergic Inflammatory Airways Disease Pathogenesis In Mice
Dewitz C; Nicatia S; McEachern EK; Rojas I; Johnson R; Nizet V; Alexander LEC
Conference publication: ANTICANCER RESEARCH. 2014;34(10):6145-6146
STROMAL HYPOXIA AND METASTASIS IN BREAST CANCER
Rundqvist H; Stockmann C; Branco-Price C; Doedens A; Johnson RS
Review: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):105-112
Tumour oxygenation: implications for breast cancer prognosis
Rundqvist H; Johnson RS
Conference publication: CANCER RESEARCH. 2013;73:b7
Hypoxia-inducible factor 1 mediates thrombosis-associated cancer progression
Evans CE; Branco-Price C; Humphries J; Wadoodi A; Saha P; Kim J-W; Belting M; Smith A; Johnson RS
Conference publication: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2013;131(2):AB239
Hypoxia Inducible Factor (HIF) Alpha Subunits Modulate Eosinophil Migration, Oxidative Burst, and Degranulation
Alexander LEC; Nicatia S; McEachern E; Johnson R; Broide DH; Nizet V
Conference publication: THORAX. 2012;67:A1
HYPOXIA-INDUCIBLE FACTOR 2α REGULATES NEUTROPHILIC INFLAMMATION IN HUMANS, MICE AND ZEBRAFISH
Thompson AAR; Elks PM; Marriott HM; Higgins KR; Parmar S; Shaw G; Eamsamarng S; McGrath EE; Formenti F; Van Eeden FJ; Kinnula VL; Pugh CW; Sabroe I; Dockrell DH; Chilvers ER; Robbins PA; Simon MC; Johnson RS; Renshaw SA; Whyte MKB; Walmsley SR
Conference publication: 2012;:a4173
HIF-2± Regulates Neutrophilic Inflammation In Humans, Mice And Zebrafish
Thompson AAR; Elks PM; Marriott HM; Higgins KR; Shaw G; Parmar S; Formenti F; Van Eden FJ; Pugh CW; Sabroe I; Dockrell DH; Robbins PA; Simon MC; Johnson RS; Renshaw SA; Whyte MKB; Walmsley SR
Conference publication: FASEB JOURNAL. 2012;26:704.15
HIF-1a gene deletion in the nucleus tractus solitarii (NTS) blunts ventilatory acclimatization to hypoxia (VAH)
Go AD; Fu Z; Johnson RS; Powell FL
Review: NATURE REVIEWS CANCER. 2011;12(1):9-22
HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression
Keith B; Johnson RS; Simon MC
Conference publication: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2011;30(4):S130
Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection In Mouse Cardiac Allografts
Keranen MAI; Syrjala S; Krebs R; Tuuminen R; Johnson RS; Nykanen AI; Lemstrom KB
Letter: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(3):797-801
A Wound Size-Dependent Effect of Myeloid Cell-Derived Vascular Endothelial Growth Factor on Wound Healing
Stockmann C; Kirmse S; Helfrich I; Weidemann A; Takeda N; Doedens A; Johnson RS
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2011;48:181
The physiology of vascular hypoxic response
Johnson R
Conference publication: BLOOD. 2011;118(21):1816
Physiology of HIF Regulation of Erythropoiesis
Johnson RS
Conference publication: CIRCULATION. 2011;124(21)
Switching of Hif-α Isoforms is Critical in the Resolution of Inflammation
Takeda N; Abe H; Senba H; Johnson R; Manabe I; Nagai R
Book chapter: TUMOUR-ASSOCIATED MACROPHAGES. 2011;p. 105-115
Vascular Endothelial Growth Factor and Tumour-Associated Macrophages
Stockmann C; Johnson RS
Conference publication: THORAX. 2010;65:A57
MACROPHAGE DELETION OF VHL RESULTS IN ALTERNATIVE ACTIVATION AND ENHANCED LUNG FIBROSIS INDEPENDENT OF HIF-1
Gibbons MA; Fitch PM; MacDuff A; Mackinnon AC; Forbes SJ; Aidinis V; Johnson RS; Sethi T; Haslett C; Rossi AG; Simpson AJ; Howie SEM; Hirani N
Editorial comment: CANCER CELL. 2010;17(6):533-534
Tumor Vessels Are Eph-ing Complicated
Branco-Price C; Johnson RS
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2010;181:a1961
Potential Role For Macrophage Hypoxia And HIF-1 Activation In Enhancing Bleomycin-induced Lung Fibrosis
Gibbons M; Fitch PM; MacKinnon AC; MacDuff A; Aidinis V; Johnson RS; Forbes SJ; Sethi T; Haslett C; Rossi AG; Simpson AJ; Howie SEM; Hirani N
Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2010;1192:322-326
Role of HIF-1α in skeletal development
Wan C; Shao J; Gilbert SR; Riddle RC; Long F; Johnson RS; Schipani E; Clemens TL
Conference publication: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2010;29(2):S116
Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection in Mouse Cardiac Allografts
Keranen MAI; Krebs R; Johnson RS; Nykanen AI; Lemstrom KB
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2010;51(13)
von Hippel-Lindau Tumor Suppressor Protein is Required for Transition From Embryonic to Adult Circulatory System in Retina
Kurihara T; Kubota Y; Ozawa Y; Noda K; Johnson RS; Goda N; Ishida S; Tsubota K; Suda T; Okano H
Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2010;51(13)
Astrocyte Hypoxic Response is Essential for Pathological but Not Developmental Angiogenesis of the Retina
Krohne TU; Weidennann A; Aguilar E; Kurihara T; Takeda N; Dorrell MI; Simon MC; Haase VH; Johnson RS; Friedlander M
Conference publication: FASEB JOURNAL. 2010;24
Effects of HIF-1α gene deletion in respiratory centers on ventilatory acclimatization to hypoxia (VAH)
Go A; Fu Z; Johnson RS; Powell FL
Conference publication: AMERICAN JOURNAL OF TRANSPLANTATION. 2010;10:386-387
Constantly Stable Hypoxia Inducible Factor-1 in Myeloid Cells Prevents Acute Rejection in Rat Cardiac Allografts
Keranen MAI; Syrjala S; Krebs R; Johnson RS; Nykanen AI; Lemstrom KB
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2010;345:121-139
Hypoxia and Metastasis in Breast Cancer
Rundqvist H; Johnson RS
Review: NATURE REVIEWS IMMUNOLOGY. 2009;9(9):609-617
Interdependence of hypoxic and innate immune responses
Nizet V; Johnson RS
Editorial comment: DEVELOPMENTAL CELL. 2009;16(6):781-782
You Don't Need a PHD to Grow a Tumor
Kim J-W; Johnson RS
Corrigendum: NATURE MEDICINE. 2009;15(4):462
VEGF modulates erythropoiesis through regulation of adult hepatic erythropoietin synthesis (vol 12, pg 793, 2006)
Tam BYFY; Wei K; Rudge JS; Hoffman J; Holash J; Park S-K; Yuan J; Hefner C; Chartier C; Lee J-S; Jiang S; Nayak NR; Kuypers FA; Ma L; Sundram U; Wu G; Garcia JA; Schrier SL; Maher JJ; Johnson RS; Yancopoulos GD; Mulligan RC; Kuo CJ
Review: KIDNEY INTERNATIONAL. 2009;75(7):682-688
Nonrenal regulation of EPO synthesis
Weidemann A; Johnson RS
Corrigendum: NATURE. 2009;457(7233):1168
A role for VEGF as a negative regulator of pericyte function and vessel maturation (vol 456, pg 809, 2008)
Greenberg JI; Shields DJ; Barillas SG; Acevedo LM; Murphy E; Huang J; Scheppke L; Stockmann C; Johnson RS; Angle N; Cheresh DA
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2009;648:369-376
Oxygen Sensing in the Brain - Invited Article
Powell FL; Kim CB; Johnson RS; Fu Z
Editorial comment: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2008;18(5):395-396
Putting the tissue and environmental 'context' into differentiation and gene regulation
Bray S; Johnson RS
Review: CELL DEATH AND DIFFERENTIATION. 2008;15(4):621-627
Biology of HIF-1α
Weidemann A; Johnson RS
Conference publication: FASEB JOURNAL. 2008;22:1016.7
HIF-1 is not a critical determinant for metabolic zonation in liver acinus
Goda N; Ochiai D; Fujiki N; Johnson RS; Suematsu M
Conference publication: WIENER KLINISCHE WOCHENSCHRIFT. 2008;120:14
Function of hypoxia-inducible factor (HIF)-1α in dendritic cells
Koehler T; Johnson RS; Weighardt H; Foerster I
Conference publication: BIRTH DEFECTS RESEARCH. 2008;82(5):314
The role of HIF in mesenchyme differentiation and limb development
Ppovot S; Zinyk D; Gunes Y; Kathri R; Le Q; Kronenberg HM; Johnson RS; Longaker MT; Schipani E; Giaccia AJ
Conference publication: FASEB JOURNAL. 2008;22
Relationship of Hypoxia to inflammation and angiogenesis
Johnson RS
Conference publication: FASEB JOURNAL. 2008;22
Hypoxia and Inflammation: Relationship to Angiogenesis
Johnson RS
Conference publication: JOURNAL OF HEART AND LUNG TRANSPLANTATION. 2008;27(2):S191
Constantly stable HIF-1α in myeloid cells prevents acute rejection in rat cardiac Allografts
Kerdnen MAJ; Tuuminen R; Nykanen AI; Tavast E; Koskinen PK; Johnson RS; Lemstrom KB
Review: JOURNAL OF MOLECULAR MEDICINE-JMM. 2007;85(12):1339-1346
Hypoxia inducible factor (HIF) function in innate immunity and infection
Zinkernagel AS; Johnson RS; Nizet V
Editorial comment: BLOOD. 2007;110(10):3492-3493
A wrinkle in the unfolding of hypoxic response: HIF and ATF4
Weidemann A; Johnson RS
Review: CANCER AND METASTASIS REVIEWS. 2007;26(2):281-290
Hypoxia: A key regulator of angiogenesis in cancer
Liao D; Johnson RS
Editorial comment: MOLECULAR CELL. 2007;26(2):157-158
Can irradiated tumors take NO for an answer?.
Johnson RS; Huang LE
Editorial comment: CELL. 2007;129(1):29-30
Waiting to inhale: HIF-1 modulates aerobic respiration
Boutin AT; Johnson RS
Conference publication: AMERICAN JOURNAL OF HEMATOLOGY. 2007;82(6):588
Microsatellite-dependent regulatory variation of NRAMP1/SLC11A1
Bayele HK; Peyssonnaux C; Giatromanolaki A; Mohamed HS; Giorgio S; Koukourakis M; Johnson RS; Blackwell JM; Nizet V; Sral SKS
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2007;618:229-244
The role of HIF-1 in hypoxic response in the skeletal muscle
Mason S; Johnson RS
Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2007;435:87-105
Transgenic models to understand hypoxia-inducible factor function
Doedens A; Johnson RS
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2006;43:45
Increased oxygen consumption in hepatocyte-specific HIF-1-targeted mice
Tsukada K; Tajima T; Kawamura T; Goda N; Johnson RS; Suematsu M
Conference publication: AMERICAN JOURNAL OF KIDNEY DISEASES. 2006;47(4):A22
HIF1 and VHL in murine podocytes are dispensable for normal glomerular development
Brukamp K; Jim B; Moeller MJ; Holzman LB; Johnson RS; Haase VH
Conference publication: CIRCULATION. 2006;114(18):4
Regulation of reactive oxygen species production and reactive oxygen species-related gene expression by hypoxia inducible factor-1α
Huang Y; Jovin IS; Hao Z; Lei L; Liu D; Johnson RS; Giordano FJ
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21:S50
Conditional deletion of HIF-1α in the condensing mesenchyme delays angiogenesis and impairs intramembranous and endochondral bone development.
Li QN; Gilbert SR; Cao X; Wan C; Serra R; Song BE; Johnson RS; Long F; Clemens TL
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21:S49
Hif-1alpha regulates differentiation of the limb bud mesenchyme and joint development.
Provot S; Zinyk D; Gunes Y; Kronenberg HM; Johnson RS; Longaker MT; Giaccia AJ; Schipani E
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2006;21:S58
The hypoxia-inducible factor pathway couples angiogenesis to osteogenesis during skeletal development.
Wang Y; Wan C; Liu X; Bouxsein ML; Faugere M; Johnson RS; Haase VH; Gerstenfeld LC; Schipani E; Clemens TL
Editorial comment: DEVELOPMENTAL CELL. 2005;9(5):575-576
A new Notch in the HIF belt: How hypoxia impacts differentiation
Cejudo-Martin P; Johnson RS
Editorial comment: SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 2005;16(4-5):461
Biology of hypoxia - Introduction
Johnson RS
Conference publication: BIOLOGY OF REPRODUCTION. 2005;:119
HIF-1 is necessary for follicular maturation.
Alam H; Flynn MP; Maizels ET; Park Y; Johnson RS; Hunzicker-Dunn M
Review: GENES & DEVELOPMENT. 2004;18(18):2183-2194
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
Giaccia AJ; Simon MC; Johnson R
Other: CANCER RESEARCH. 2004;64(9):3350-3356
Proceedings of the Oxygen Homeostasis/Hypoxia Meeting.
Kaufman B; Scharf O; Arbeit J; Ashcroft M; Brown JM; Bruick RK; Chapman JD; Evans SM; Giaccia AJ; Harris AL; Huang E; Johnson R; Kaelin W; Koch CJ; Maxwell P; Mitchell J; Neckers L; Powis G; Rajendran J; Semenza GL; Simons J; Storkebaum E; Welch MJ; Whitelaw M; Melillo G; Ivy SP
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2004;14(1):81-85
HIF-1 and hypoxic response: the plot thickens
Poellinger L; Johnson RS
Conference publication: JOURNAL OF HEPATOLOGY. 2004;40:18
Conditional loss of HIF-1α delays liver regeneration and aggravates toxicity after carbon tetrachloride administration
Cramer T; Benckert C; Johnson RS; Wiedenmann B; Hoecker M
Conference publication: THORAX. 2004;59(1):2
Hypoxia inhibits neutrophil apoptosis via hypoxia inducible factor (HIF)-1α-dependent regulation of NFκB
Walmsley SR; Print C; Johnson RS; Cramer T; Condliffe AM; Chilvers ER
Conference publication: CIRCULATION. 2004;110(17):83
Hypoxia-inclucible factor (HIF)-1 α influences vascular remodeling associated with altered flow
Liu DG; Lei L; Huang Y; Jovin IS; Hickey RP; Yu J; Johnson RS; Sessa WC; Giordano FJ
Conference publication: CIRCULATION. 2004;110(17):25
Endothelial expression of HIF-1α is a critical determinant of whole-organ glucose uptake and oxidation
Huang Y; Liu DG; Hickey RP; Lei L; Yeh J; Johnson RS; Russell R; Giordano FJ
Conference publication: CIRCULATION. 2004;110(17):45
Malignant transformation of heart muscle in the absence of the von Hippel-Lindau protein
Lei L; Mason S; Liu DG; Huang Y; Hickey RP; Johnson RS; Giordano FJ
Conference publication: AMERICAN JOURNAL OF TRANSPLANTATION. 2004;4:514
Hypoxia inducible factor-1α regulates TCR signal transduction.
Neumann AK; Biju MP; Johnson RS; Haase VH; Turka LA
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2004;19:S15
Conditional disruption of hypoxia inducible factor 1 α in mouse osteoblasts reduces bone volume.
Deng L; Akeno N; Mukherjee A; Bouxsein M; Faugere M; Johnson RS; Clemens TL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2004;63:146
HIF-1alpha plays a critical role in chondrocytes during low oxygen tension: Implications for osteoarthritis
Pfander D; Cramer T; Johnson RS; Swoboda B
Review: NATURE REVIEWS DRUG DISCOVERY. 2003;2(10):803-811
HIF-1 as a target for drug development
Giaccia A; Siim BG; Johnson RS
Review: ANTIOXIDANTS & REDOX SIGNALING. 2003;5(4):467-473
HIF-1 in cell cycle regulation, apoptosis, and tumor progression
Goda N; Dozier SJ; Johnson RS
Conference publication: HEPATOLOGY. 2003;38(4):270A
Oxygen modulation of cytochrome P450 pathways: Role of oxygen gradients and HIF-1alpha in hepatocytes in vitro.
Allen JW; Johnson RS; Bhatia SN
Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14:588A
HIF-1-regulated gene expression in murine kidneys and its implication for renal fibrosis
Higgins DF; Akai Y; Biju MP; Johnson RS; Haase VH
Conference publication: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2003;14:344A
A novel role for the VHL tumor suppressor in thymocyte apoptosis.
Biju MP; Neumann AK; Bensinger SJ; Johnson RS; Turka LA; Haase VH
Corrigendum: CELL. 2003;113(3):419
HIF-1α is essential for myeloid cell-mediated inflammation (vol 112, pg 648, 2003)
Cramer T; Yamanishi Y; Clausen BE; Förster I; Pawlinski R; Mackman N; Haase VH; Jaenisch R; Corr M; Nizet V; Firestein GS; Gerber HP; Ferrara N; Johnson RS
Corrigendum: JOURNAL OF CELL SCIENCE. 2003;116(10):2113
HIF-1α controls extracellular matrix synthesis by epiphyseal chondrocytes (vol 116, pg 1819, 2003)
Pfander D; Cramer T; Schipani E; Johnson RS
Corrigendum: JOURNAL OF CELL BIOLOGY. 2003;161(2):441
c-jun is essential for sympathetic neuronal death induced by NFG withdrawal but not by p75 activation (vol 158, pg 453, 2002)
Palmada M; Kanwal S; Rutkoski N; Gustafson-Brown C; Johnson RS; Wisdom R; Carter BD
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2003;62:111
HIF-1alpha controls energy generation and matrix synthesis by murine chondrocytes
Pfander D; Cramer T; Johnson RS; Swoboda B
Corrigendum: CANCER CELL. 2002;1(4):403
Two HIFs may be better than one (vol 1, pg 212, 2002)
Seagroves T; Johnson RS
Editorial comment: CANCER CELL. 2002;1(3):211-213
Two HIFs may be better than one
Seagroves T; Johnson RS
Conference publication: GASTROENTEROLOGY. 2002;122(4):A400
HIF-1alpha expression in myeloid cells as an essential regulator of inflammation
Cramer T; Foerster I; Johnson RS
Conference publication: GASTROENTEROLOGY. 2002;122(4):A6
Hypoxia-inducible factor-1 (HIF-1) is protective for experimental colitis
Karhausen JA; Furuta GT; Haase VH; Jaenisch R; Johnson RS; Colgan SP
Conference publication: CIRCULATION. 2002;106(19):316
Physiologic and gene expression effects of conditional HIF1α deletion from cardiac and smooth muscle
Huang Y; Yeh JL; Hickey RP; Johnson RS; Giordano FJ
Conference publication: MOLECULAR BIOLOGY OF THE CELL. 2002;13:175A
Unstable kinetochore-microtubule capture and chromosomal instability following deletion of CENP-E
Putkey FR; Cramer T; Morphew MK; Silk AD; Johnson RS; McIntosh JR; Cleveland DW
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2002;17:S160-S161
The tumor suppressor gene VHL is a critical modulator of cell proliferation and cell growth in the mammalian growth plate.
Schipani E; Kobayashi T; MacLean HE; Knight MC; Johnson RS; Haase V
Review: CURRENT OPINION IN GENETICS & DEVELOPMENT. 2001;11(1):35-40
Angiogenesis: the role of the microenvironment in flipping the switch
Giordano FJ; Johnson RS
Conference publication: JOURNAL OF BONE AND MINERAL RESEARCH. 2001;16:S137
Essential role of HIF-1alpha in growth plate development.
Schipani E; Ryan HE; Kobayashi T; Knight M; Johnson RS
Conference publication: BLOOD. 1998;92(10):172A-173A
Characterization of the structure and function of CD39.
Gayle RB; Gimpel SD; Maliszewski CR; Schoenborn MA; Caspary RG; DuBose RF; Ketchem RR; Johnson RS; Wallace AR; Drosopoulos JHF; Islam N; Broekman MJ; Marcus AJ
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Grants

Increasing immunotherapeutic efficacy through manipulation of hypoxic response
Swedish Research Council
1 January 2023 - 31 December 2026
Enhancing immunotherapy through manipulation of metabolism
Barncancerfonden
1 January 2023 - 31 December 2023
Johnson, Randall – Developing next stage immunotherapeutics by augmenting hypoxic response
Swedish Cancer Society
1 January 2022
Metabolic and epigenetic regulation of cancer associated fibroblasts by angiotensin II
Canadian Institutes of Health Research
1 June 2021 - 31 August 2024
Oxygen and immunity
Swedish Research Council
1 January 2020 - 31 December 2022
Oxygen and immune response
Wellcome Trust
1 January 2019 - 31 July 2024
Acute deficiency and activation of the immune system in cancer
Swedish Cancer Society
1 January 2018
Tumor hypoxia and the immune system – protective or harmful?
Swedish Research Council
1 January 2017 - 31 December 2019
Mechanism of signal transduction and gene regulation in hypoxia
Swedish Research Council
1 January 2016 - 31 December 2018
Acute deficiency and inflammation in prognosis and treatment of breast cancer
Swedish Cancer Society
1 January 2016
Acute deficiency and inflammation in prognosis and treatment of breast cancer
Swedish Cancer Society
1 January 2015
Hypoxia and inflammation in the spread of breast cancer.
Swedish Cancer Society
1 January 2014
Hypoxia and Inflammation in Breast Cancer Metastasis
Swedish Research Council
1 January 2014 - 31 December 2016
Metabolic Regulation of T cell Immunity
National Institute of Allergy and Infectious Diseases
1 August 2012 - 31 July 2017
The physiology of hypoxic response
Wellcome Trust
1 August 2011 - 31 December 2018
Boosting Innate Immunity Through HIF to Treat Antibiotic-Resistant Infections
National Institute of Allergy and Infectious Diseases
5 April 2011 - 31 March 2017
Myeloid Vascular Endothelial Growth Factor Expression & its Role in Tumorigenesis
National Cancer Institute
6 January 2011 - 31 December 2015
Boosting Innate Immunity Through HIF to Treat Drug-Resistant Bacterial Infections
National Institute of Allergy and Infectious Diseases
2 August 2010 - 31 July 2011
Hypoxic response and inflammation: role in breast cancer progression.
Susan G. Komen Breast Cancer Foundation
14 August 2008 - 13 February 2012
The role of HIF-1 in chondrocyte
United States-Israel Binational Science Foundation
1 January 2007
The importance of tumor suppressor von Hippel-Lindau protein (pVHL), and hypoxia inducible factor HIF-1 alpha in metastatic tumor growth
Deutsche Forschungsgemeinschaft
1 January 2006 - 31 December 2009
The importance of the Hypoxia-inducible factors 1 alpha and reactive oxygen species in endothelial cells for interaction between tumor tissue and vessels supplying under the radiotherapy
Deutsche Forschungsgemeinschaft
1 January 2006 - 31 December 2009
Hypoxia-induced Responses and Innate Immunity
National Institute of Allergy and Infectious Diseases
1 May 2005 - 31 January 2009
Biology of Hypoxia
National Institute on Aging
1 April 2004 - 31 March 2005
The Contribution of Hypoxia-Inducible Factor (HIF)-1Alpha and c-jun to Mammary Gland Development and Mammary Tumorigenesis
Susan G. Komen Breast Cancer Foundation
1 May 2000 - 30 April 2003
Hypoxia Response in the Stroma During Tumorigenesis
National Cancer Institute
1 July 1999 - 30 April 2013
GENETIC ANALYSIS OF RAS TRANSFORMATION AND JUN FUNCTION
National Cancer Institute
20 April 1997 - 31 January 2002
IVEM and Image Analysis Resource
National Center for Advancing Translational Sciences
12 December 1988 - 31 March 2014
Specialized Cancer Center Support Grant
National Cancer Institute
31 March 1978 - 30 April 2025
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