Noemi Nagy

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE COMMUNICATIONS. 2023;14(1):8315
Remodeling of the ribosomal quality control and integrated stress response by viral ubiquitin deconjugases
Liu J; Nagy N; Ayala-Torres C; Aguilar-Alonso F; Morais-Esteves F; Xu S; Masucci MG
Article: ONCOIMMUNOLOGY. 2022;11(1):2109861
IFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+CML stem/progenitor cells potentially through the upregulation of multiple key survival factors
Ujvari D; Malyukova A; Zovko A; Yektaei-Karin E; Madapura HS; Keszei M; Nagy N; Lotfi K; Bjorn N; Wallvik J; Stenke L; Salamon D
Article: GENETICS IN MEDICINE. 2022;24(1):157-169
Novel loss-of-function variant in DENND5A impedes melanosomal cargo transport and predisposes to familial cutaneous melanoma
Yang M; Johnsson P; Brautigam L; Yang XR; Thrane K; Gao J; Tobin NP; Zhou Y; Yu R; Nagy N; Engstrom PG; Tuominen R; Eriksson H; Lundeberg J; Tucker MA; Goldstein AM; Egyhazi-Brage S; Zhao J; Cao Y; Hoiom V
Article: CELL DEATH AND DISEASE. 2021;12(10):875
Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells
Malyukova A; Ujvari D; Yektaei-Karin E; Zovko A; Madapura HS; Keszei M; Nagy N; Lotfi K; Bjorn N; Wallvik J; Tamai M; Nguyen TTT; Akahane K; Inukai T; Stenke L; Salamon D
Article: PLOS PATHOGENS. 2021;17(9):e1009954
The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection
Li J; Nagy N; Liu J; Gupta S; Frisan T; Hennig T; Cameron DP; Baranello L; Masucci MG
Article: MALARIA JOURNAL. 2021;20(1):303
Direct contact between Plasmodium falciparum and human B-cells in a novel co-culture increases parasite growth and affects B-cell growth
Reddy SB; Nagy N; Ronnberg C; Chiodi F; Lugaajju A; Heuts F; Szekely L; Wahlgren M; Persson KEM
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2021;78(8):4019-4033
Immune cells lacking Y chromosome show dysregulation of autosomal gene expression
Dumanski JP; Halvardson J; Davies H; Rychlicka-Buniowska E; Mattisson J; Moghadam BT; Nagy N; Weglarczyk K; Bukowska-Strakova K; Danielsson M; Olszewski P; Piotrowski A; Oerton E; Ambicka A; Przewoznik M; Belch L; Grodzicki T; Chlosta PL; Imreh S; Giedraitis V; Kilander L; Nordlund J; Ameur A; Gyllensten U; Johansson A; Jozkowicz A; Siedlar M; Klich-Raczka A; Jaszczynski J; Enroth S; Baran J; Ingelsson M; Perry JRB; Rys J; Forsberg LA
Article: HAEMATOLOGICA. 2020;105(5):1339-1350
An intronic deletion in megakaryoblastic leukemia 1 is associated with hyperproliferation of B cells in triplets with Hodgkin lymphoma
Record J; Sendel A; Kritikou JS; Kuznetsov NV; Brauner H; He M; Nagy N; Oliveira MMS; Griseti E; Haase CB; Dahlstrom J; Boddul S; Wermeling F; Thrasher AJ; Liu C; Andersson J; Claesson H-E; Winqvist O; Burns SO; Bjorkholm M; Westerberg LS
Article: ONCOGENE. 2020;39(3):603-616
The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization
Wang J; Nagy N; Masucci MG
Article: INTERNATIONAL JOURNAL OF CANCER. 2019;144(1):98-109
A bacterial genotoxin causes virus reactivation and genomic instability in Epstein-Barr virus infected epithelial cells pointing to a role of co-infection in viral oncogenesis
Frisan T; Nagy N; Chioureas D; Terol M; Grasso F; Masucci MG
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;498(3):502-508
Interferon γ is a strong, STAT1-dependent direct inducer of BCL6 expression in multiple myeloma cells
Ujvari D; Nagy N; Madapura HS; Kallas T; Krohnke MCL; Stenke L; Klein E; Salamon D
Article: ONCOGENE. 2017;36(32):4619-4628
Interferon γ is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells
Madapura HS; Nagy N; Ujvari D; Kallas T; Krohnke MCL; Amu S; Bjorkholm M; Stenke L; Mandal PK; McMurray JS; Keszei M; Westerberg LS; Cheng H; Xue F; Klein G; Klein E; Salamon D
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1532:229-240
Mice with Reconstituted Human Immune System Components as a Tool to Study Immune Cell Interactions in EBV Infection.
Heuts F; Nagy N
Article: METHODS IN MOLECULAR BIOLOGY. 2017;1532:57-64
Establishment of EBV-Infected Lymphoblastoid Cell Lines.
Nagy N
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:244
Dendritic Cell Response to HIV-1 Is Controlled by Differentiation Programs in the Cells and Strain-Specific Properties of the Virus
Nasi A; Amu S; Gothlin M; Jansson M; Nagy N; Chiodi F; Rethi B
Article: CELL CYCLE. 2016;15(9):1267-1275
cMyc-p53 feedback mechanism regulates the dynamics of T lymphocytes in the immune response
Madapura HS; Salamon D; Wiman KG; Lain S; Klein E; Nagy N
Article: JOURNAL OF IMMUNOLOGY. 2014;192(12):5852-5862
Exosomes Derived from Burkitt's Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells
Gutzeit C; Nagy N; Gentile M; Lyberg K; Gumz J; Vallhov H; Puga I; Klein E; Gabrielsson S; Cerutti A; Scheynius A
Article: JOURNAL OF VIROLOGY. 2014;88(6):3235-3245
T Cells Modulate Epstein-Barr Virus Latency Phenotypes during Infection of Humanized Mice
Heuts F; Rottenberg ME; Salamon D; Rasul E; Adori M; Klein G; Klein E; Nagy N
Article: GENOME RESEARCH. 2014;24(2):177-184
Large-scale hypomethylated blocks associated with Epstein-Barr virus-induced B-cell immortalization
Hansen KD; Sabunciyan S; Langmead B; Nagy N; Curley R; Klein G; Klein E; Salamon D; Feinberg AP
Article: PLOS ONE. 2014;9(8):e106008
The MEC1 and MEC2 Lines Represent Two CLL Subclones in Different Stages of Progression towards Prolymphocytic Leukemia
Rasul E; Salamon D; Nagy N; Leveau B; Banati F; Szenthe K; Koroknai A; Minarovits J; Klein G; Klein E
Article: JOURNAL OF VIROLOGY. 2013;87(24):13446-13455
Epstein-Barr Virus Coinfection in Children Boosts Cytomegalovirus-Induced Differentiation of Natural Killer Cells
Saghafian-Hedengren S; Sohlberg E; Theorell J; Carvalho-Queiroz C; Nagy N; Persson J-O; Nilsson C; Bryceson YT; Sverremark-Ekstrom E
Article: JOURNAL OF IMMUNOLOGY. 2013;191(11):5669-5676
Cytomegalovirus-Seropositive Children Show Inhibition of In Vitro EBV Infection That Is Associated with CD8⁺CD57⁺ T Cell Enrichment and IFN-γ
Sohlberg E; Saghafian-Hedengren S; Rasul E; Marchini G; Nilsson C; Klein E; Nagy N; Sverremark-Ekstrom E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2013;435(1):8-15
The role of DNA hypomethylation, histone acetylation and in vivo protein-DNA binding in Epstein-Barr virus-induced CD23 upregulation
Szenthe K; Koroknai A; Banati F; Bathori Z; Niller HH; Wolf H; Nagy N; Klein E; Minarovits J; Salamon D
Article: CELL CYCLE. 2012;11(24):4563-4569
p53 contributes to T cell homeostasis through the induction of pro-apoptotic SAP
Madapura HS; Salamon D; Wiman KG; Lain S; Klein G; Klein E; Nagy N
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2012;385(1-2):60-70
Simultaneous detection of the two main proliferation driving EBV encoded proteins, EBNA-2 and LMP-1 in single B cells
Rasul AE; Nagy N; Sohlberg E; Adori M; Claesson H-E; Klein G; Klein E
Article: JOURNAL OF VIROLOGY. 2012;86(8):4701-4707
Latency Type-Dependent Modulation of Epstein-Barr Virus-Encoded Latent Membrane Protein 1 Expression by Type I Interferons in B Cells
Salamon D; Adori M; Ujvari D; Wu L; Kis LL; Madapura HS; Nagy N; Klein G; Klein E
Article: CYTOKINE. 2012;57(3):360-371
Type I interferons directly down-regulate BCL-6 in primary and transformed germinal center B cells: Differential regulation in B cell lines derived from endemic or sporadic Burkitt's lymphoma
Salmon D; Adori M; He M; Bonelt P; Severinson E; Kis LL; Wu L; Ujvari D; Leveau B; Nagy N; Klein G; Klein E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(5):1512-1517
Soluble factors produced by activated CD4⁺ T cells modulate EBV latency
Nagy N; Adori M; Rasul A; Heuts F; Salamon D; Ujvari D; Madapura HS; Leveau B; Klein G; Klein E
Article: INTERNATIONAL JOURNAL OF CANCER. 2012;130(1):48-58
Monocytes enhance cell proliferation and LMP1 expression of nasal natural killer/T-cell lymphoma cells by cell contact-dependent interaction through membrane-bound IL-15
Ishii H; Takahara M; Nagato T; Kis LL; Nagy N; Kishibe K; Harabuchi Y; Klein E
Article: BLOOD. 2011;117(1):165-174
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma
Kis LL; Gerasimcik N; Salamon D; Persson EK; Nagy N; Klein G; Severinson E; Klein E
Article: JOURNAL OF IMMUNOLOGY. 2011;186(1):73-82
Exosomes Containing Glycoprotein 350 Released by EBV-Transformed B Cells Selectively Target B Cells through CD21 and Block EBV Infection In Vitro
Vallhov H; Gutzeit C; Johansson SM; Nagy N; Paul M; Li Q; Friend S; George TC; Klein E; Scheynius A; Gabrielsson S
Article: EXPERIMENTAL HEMATOLOGY. 2010;38(12):1219-1230
Chronic lymphoid leukemia cells are highly sensitive to the combination of prednisolone and daunorubicin, but much less to doxorubicin or epirubicin
Skribek H; Otvos R; Flaberg E; Nagy N; Markasz L; Eksborg S; Masszi T; Kozma A; Adam E; Miseta A; Klein E; Szekely L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(2):872-877
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter
Kis LL; Salamon D; Persson EK; Nagy N; Scheeren FA; Spits H; Klein G; Klein E
Article: CELL CYCLE. 2009;8(19):3086-3090
The apoptosis modulating role of SAP (SLAM associated protein) contributes to the symptomatology of the X linked lymphoproliferative disease
Nagy N; Matskova L; Hellman U; Klein G; Klein E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(29):11966-11971
The proapoptotic function of SAP provides a clue to the clinical picture of X-linked lymphoproliferative disease
Nagy N; Matskova L; Kis LL; Hellman U; Klein G; Klein E
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;119(12):2775-2783
Concomitant increase of LMP1 and CD25 (IL-2-receptor α) expression induced by IL-10 in the EBV-positive NK lines SNK6 and KAI3
Takahara M; Kis LL; Nagy N; Liu A; Harabuchi Y; Klein G; Klein E
Article: BLOOD. 2006;107(7):2928-2935
IL-10 can induce the expression of EBV-encoded latent membrane protein-1 (LMP-1) in the absence of EBNA-2 in B lymphocytes and in Burkitt lymphoma-and NK lymphoma-derived cell lines
Kis LL; Takahara M; Nagy N; Klein G; Klein E
Article: VIRUS GENES. 2005;30(3):323-330
EBV infection induces expression of the transcription factors ATF-2/c-Jun in B lymphocytes but not in B-CLL cells
Bandobashi K; Liu AQ; Nagy N; Kis LL; Nishikawa J; Björkholm M; Klein G; Klein E
Article: INTERNATIONAL JOURNAL OF CANCER. 2005;113(6):937-945
In vitro EBV-infected subline of KMH2, derived from Hodgkin lymphoma, expresses only EBNA-1, while CD40 ligand and IL-4 induce LMP-1 but not EBNA-2
Kis LL; Nishikawa J; Takahara M; Nagy N; Matskova L; Takada K; Elmberger PG; Ohlsson A; Klein G; Klein E
Article: ONCOGENE. 2004;23(53):8563-8570
Wild-type p53 activates SAP expression in lymphoid cells
Nagy N; Takahara M; Nishikawa J; Bourdon JC; Kis LL; Klein G; Klein E
Article: VIRUS GENES. 2004;28(1):121-128
Upregulation of LMP1 expression by histone deacetylase inhibitors in an EBV carrying NPC cell line
Nishikawa J; Kis LL; Liu AQ; Zhang XN; Takahara M; Bandobashi K; Kiss C; Nagy N; Okita K; Klein G; Klein E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(11):6694-6699
Disruption of the estrogen receptor β gene in mice causes myeloproliferative disease resembling chronic myeloid leukemia with lymphoid blast crisis
Shim GJ; Wang L; Andersson S; Nagy N; Kis LL; Zhang QH; Mäkelä S; Warner M; Gustafsson J
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;104(5):658-661
Expression of SH2D1A in five classical Hodgkin's disease-derived cell lines
Kis LL; Nagy N; Klein G; Klein E
Article: INTERNATIONAL JOURNAL OF CANCER. 2002;100(4):433-440
SH2D1A expression in Burkitt lymphoma cells is restricted to EBV positive group I lines and is downregulated in parallel with immunoblastic transformation
Nagy N; Maeda A; Bandobashi K; Kis LL; Nishikawa J; Trivedi P; Faggioni A; Klein G; Klein E
Article: IMMUNOLOGY LETTERS. 2002;80(3):181-188
SH2D1A expression reflects activation of T and NK cells in cord blood lymphocytes infected with EBV and treated with the immunomodulator PSK
Liu AQ; Klein G; Bandobashi K; Klein E; Nagy N
Article: VIROLOGY. 2001;288(2):275-282
Intranuclear localization of the transcription coadaptor CBP/p300 and the transcription factor RBP-Jk in relation to EBNA-2 and-5 in B lymphocytes
Bandobashi K; Maeda A; Teramoto N; Nagy N; Székely L; Taguchi H; Miyoshi I; Klein G; Klein E
Article: JOURNAL OF HUMAN VIROLOGY. 2001;4(5):227-237
Epstein-Barr virus can infect B-chronic lymphocytic leukemia cells but it does not orchestrate the cell cycle regulatory proteins
Maeda A; Bandobashi K; Nagy N; Teramoto N; Gogolák P; Pokrovskaja K; Székely L; Björkholm M; Klein G; Klein E
Article: INTERNATIONAL JOURNAL OF CANCER. 2001;93(5):714-719
EBNA promoter usage in EBV-negative Burkitt lymphoma cell lines converted with a neomycin-resistant EBV strain
Maeda A; Kiss C; Chen F; Ehlin-Henriksson B; Nagy N; Szekely L; Takada K; Klein E; Klein G
Article: INTERNATIONAL JOURNAL OF CANCER. 2000;88(3):439-447
SH2D1A and SLAM protein expression in human lymphocytes and derived cell lines
Nagy N; Cerboni C; Mattsson K; Maeda A; Gogolák P; Sümegi J; Lányi A; Székely L; Carbone E; Klein G; Klein E
Article: JOURNAL OF HUMAN VIROLOGY. 2000;3(3):125-136
Epstein-Barr virus-infected B-chronic lymphocyte leukemia cells express the virally encoded nuclear proteins but they do not enter the cell cycle
Teramoto N; Gogolák P; Nagy N; Maeda A; Kvarnung K; Björkholm M; Klein E
Article: INTERNATIONAL IMMUNOLOGY. 2000;12(3):281-293
A repetitive sequence of Epstein-Barr virus nuclear antigen 6 comprises overlapping T cell epitopes which induce HLA-DR-restricted CD4⁺ T lymphocytes
Rajnavölgyi É; Nagy N; Thuresson B; Dosztányi Z; Simon A; Simon I; Karr RW; Ernberg I; Klein E; Falk KI
Article: IMMUNOLOGY LETTERS. 1998;64(2-3):153-160
Tumor surveillance:: expression of the transporter associated with antigen processing (TAP-1) in ex-vivo human tumor samples and its elevation by in vitro treatment with IFN-γ and TNF-α
Nagy N; Vanky F; Klein E
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 1998;45(6):306-312
Transforming growth factor β, (TGFβ) secreted by immunogenic ex vivo human carcinoma cells, counteracts the activation and inhibits the function of autologous cytotoxic lymphocytes.: Pretreatment with interferon γ and tumor necrosis factor α reduces the production of active TGFβ
Nagy N; Vanky F
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 1997;43(6):317-323
Human ex vivo carcinoma cells produce transforming growth factor beta and thereby can inhibit lymphocyte functions in vitro
Vanky F; Nagy N; Hising C; Sjovall K; Larson B; Klein E
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Corrigendum: MALARIA JOURNAL. 2021;20(1):323
Direct contact between Plasmodium falciparum and human B-cells in a novel co-culture increases parasite growth and affects B-cell growth (vol 20, 303, 2021)
Reddy SB; Nagy N; Ronnberg C; Chiodi F; Lugaajju A; Heuts F; Szekely L; Wahlgren M; Persson KEM
Corrigendum: ONCOGENE. 2020;39(9):2028
The Epstein-Barr virus nuclear antigen-1 upregulates the cellular antioxidant defense to enable B-cell growth transformation and immortalization (vol 39, pg 603, 2020)
Wang J; Nagy N; Masucci MG
Review: CANCER IMMUNOLOGY RESEARCH. 2015;3(2):97-102
Modification of Cell Differentiation, One of the Mechanisms in the Surveillance of Malignancy
Klein E; Nagy N; Rasul E
Review: ONCOIMMUNOLOGY. 2013;2(2):e23035
EBV genome carrying B lymphocytes that express the nuclear protein EBNA-2 but not LMP-1 Type IIb latency
Klein E; Nagy N; Rasul AE
Review: SEMINARS IN CANCER BIOLOGY. 2010;20(6):410-415
Restricted expression of EBV encoded proteins in in vitro infected CLL cells
Klein E; Nagy N
Published conference paper: IMMUNOLOGY LETTERS. 2010;130(1-2):13-18
Deficiency of the proapoptotic SAP function in X-linked lymphoproliferative disease aggravates Epstein-Barr virus (EBV) induced mononucleosis and promotes lymphoma development
Nagy N; Klein E
Review: SEMINARS IN CANCER BIOLOGY. 2009;19(6):407-410
To the genesis of Burkitt lymphoma: Regulation of apoptosis by EBNA-1 and SAP may determine the fate of Ig-myc translocation carrying B lymphocytes
Nagy N; Klein G; Klein E
Thesis / dissertation: 2006
Expression and function of the small immune adaptor protein SAP
Nagy, Noemi
Published conference paper: IMMUNOLOGY LETTERS. 2006;104(1-2):83-88
Cytokine mediated induction of the major Epstein-Barr virus (EBV)-encoded transforming protein, LMP-1
Kis LL; Takahara M; Nagy N; Klein G; Klein E
Published conference paper: IMMUNOLOGY LETTERS. 2002;82(1-2):141-147
The X-linked lymphoproliferative disease gene product SAP is expressed in activated T and NK cells
Nagy N; Mattsson K; Maeda A; Liu AQ; Székely L; Klein E
Published conference paper: IMMUNOLOGY LETTERS. 1999;68(1):147-154
LMP-1, the Epstein-Barr virus-encoded oncogene with a B cell activating mechanism similar to CD40
Klein E; Teramoto N; Gogolák P; Nagy N; Björkholm M
Letter: BLOOD. 1998;92(11):4482-4484
Nerve growth factor released by CD40 ligand-transfected L cells:: Implications for functional and phenotypic studies on CD40⁺ cells
De Milito A; Nagy N; Samuelsson A; Chiodi F; Rajnavölgyi E

Anställningar

Forskningsspecialist, Cell- och molekylärbiologi, Karolinska Institutet, 2022-

Examina och utbildning

MEDICINE DOKTORSEXAMEN, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2006

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