Nico Dantuma
Professor
E-postadress: nico.dantuma@ki.se
Telefon: +46852487384
Besöksadress: Solnavägen 9, 17165 Stockholm
Postadress: C5 Cell- och molekylärbiologi, C5 CMB Dantuma, 171 77 Stockholm
Del av:
- Institutionen för cell- och molekylärbiologi
- Nico Dantumas forskargrupp
Om mig
- Nico Dantuma är professor i molekylär cellbiologi sedan 2011. Hans forskning handlar om betydelsen av ubikvitin-proteasomsystemet vid utvecklingen av neurodegenerativa sjukdomar och cancer, liksom behandlingspotentialen vid modifiering av detta system.
Artiklar
- Article: AUTOPHAGY. 2025;21(5):1019-1038Ayala-Torres C; Liu J; Dantuma NP; Masucci MG
- Journal article: BIOCHIMIE. 2024;226:4-9Coux O; Farràs R; Core Group of ProteoCure
- Article: COMMUNICATIONS BIOLOGY. 2024;7(1):1282Xu S; Gierisch ME; Barchi E; Poser I; Alberti S; Salomons FA; Dantuma NP
- Article: EMBO JOURNAL. 2023;42(3):e111802Xu S; Gierisch ME; Schellhaus AK; Poser I; Alberti S; Salomons FA; Dantuma NP
- Article: AUTOPHAGY. 2022;18(7):1486-1502Giovannucci TA; Salomons FA; Stoy H; Herzog LK; Xu S; Qian W; Merino LG; Gierisch ME; Haraldsson M; Lystad AH; Uvell H; Simonsen A; Gustavsson A-L; Vallin M; Dantuma NP
- Article: COMMUNICATIONS BIOLOGY. 2022;5(1):505Schellhaus AK; Xu S; Gierisch ME; Vornberger J; Johansson J; Dantuma NP
- Article: CELL DEATH & DISEASE. 2021;12(10):914Giovannucci TA; Salomons FA; Haraldsson M; Elfman LHM; Wickstroem M; Young P; Lundbaeck T; Eirich J; Altun M; Jafari R; Gustavsson A-L; Johnsen JI; Dantuma NP
- Article: JOURNAL OF CELL SCIENCE. 2021;134(3):jcs247809Pfeiffer A; Herzog LK; Luijsterburg MS; Shah RG; Rother MB; Stoy H; Kuhbacher U; van Attikum H; Shah GM; Dantuma NP
- Article: SCIENTIFIC REPORTS. 2020;10(1):22334Richard TJC; Herzog LK; Vornberger J; Rahmanto AS; Sangfelt O; Salomons FA; Dantuma NP
- Article: SCIENTIFIC REPORTS. 2020;10(1):21765Biverstal H; Kumar R; Schellhaus AK; Sarr M; Dantuma NP; Abelein A; Johansson J
- Article: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2020;1233:237-260Dantuma NP; Herzog LK
- Article: AGING CELL. 2020;19(1):e13051Herzog LK; Kevei E; Marchante R; Bottcher C; Bindesboll C; Lystad AH; Pfeiffer A; Gierisch ME; Salomons FA; Simonsen A; Hoppe T; Dantuma NP
- Article: JOURNAL OF CELL SCIENCE. 2017;130(19):3336-3346Godderz D; Giovannucci TA; Lalakova J; Menendez-Benito V; Dantuma NP
- Article: EMBO JOURNAL. 2017;36(8):1066-1083Pfeiffer A; Luijsterburg MS; Acs K; Wiegant WW; Helfricht A; Herzog LK; Minoia M; Bottcher C; Salomons FA; van Attikum H; Dantuma NP
- Article: JOURNAL OF CELL SCIENCE. 2017;130(6):1134-1146Bot C; Pfeiffer A; Giordano F; Manjeera DE; Dantuma NP; Strom L
- Article: SCIENTIFIC REPORTS. 2016;6:27703Bott LC; Salomons FA; Maric D; Liu Y; Merry D; Fischbeck KH; Dantuma NP
- Article: HUMAN MOLECULAR GENETICS. 2016;25(10):1979-1989Bott LC; Badders NM; Chen K-L; Harmison GG; Bautista E; Shih CC-Y; Katsuno M; Sobue G; Taylor JP; Dantuma NP; Fischbeck KH; Rinaldi C
- Journal article: NEUROLOGY. 2015;84(14_supplement)Rinaldi C; Bott L; Badders N; Bautista E; Harmison G; Chen K-L; Taylor JP; Dantuma N; Fischbeck K
- Article: HUMAN MOLECULAR GENETICS. 2015;24(5):1305-1321Baek J-H; Schmidt E; Viceconte N; Strandgren C; Pernold K; Richard TJC; Van Leeuwen FW; Dantuma NP; Damberg P; Hultenby K; Ulfhake B; Mugnaini E; Rozell B; Eriksson M
- Article: SCIENTIFIC REPORTS. 2015;5:7615Godderz D; Heinen C; Marchese FP; Kurz T; Acs K; Dantuma NP
- Article: PLOS GENETICS. 2014;10(10):e1004680Jeppsson K; Carlborg KK; Nakato R; Berta DG; Lilienthal I; Kanno T; Lindqvist A; Brink MC; Dantuma NP; Katou Y; Shirahige K; Sjogren C
- Article: NUCLEIC ACIDS RESEARCH. 2013;41(5):2950-2962Coppotelli G; Mughal N; Callegari S; Sompallae R; Caja L; Luijsterburg MS; Dantuma NP; Moustakas A; Masucci MG
- Article: EMBO JOURNAL. 2012;31(11):2511-2527Luijsterburg MS; Acs K; Ackermann L; Wiegant WW; Bekker-Jensen S; Larsen DH; Khanna KK; van Attikum H; Mailand N; Dantuma NP
- Article: JOURNAL OF CELL BIOLOGY. 2012;197(2):267-281Luijsterburg MS; Lindh M; Acs K; Vrouwe MG; Pines A; van Attikum H; Mullenders LH; Dantuma NP
- Article: JOURNAL OF CELL BIOLOGY. 2012;196(6):681-688Bergink S; Toussaint W; Luijsterburg MS; Dinant C; Alekseev S; Hoeiimakers JHJ; Dantuma NP; Houtsmuller AB; Vermeulen W
- Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2011;18(12):1345-U55Acs K; Luijsterburg MS; Ackermann L; Salomons FA; Hoppe T; Dantuma NP
- Article: FEBS LETTERS. 2011;585(16):2568-2574Dennissen FJA; Kholod N; Hermes DJHP; Kemmerling N; Steinbusch HWM; Dantuma NP; van Leeuwen FW
- Journal article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2011;4(4):428-432Haapasalo A; Viswanathan J; Kurkinen KMA; Bertram L; Soininen H; Dantuma NP; Tanzi RE; Hiltunen M
- Journal article: COMMUNICATIVE AND INTEGRATIVE BIOLOGY. 2011;4(4):428-432Haapasalo A; Viswanathan J; Kurkinen KM; Bertram L; Soininen H; Dantuma NP; Tanzi RE; Hiltunen M
- Article: TRAFFIC. 2011;12(3):330-348Viswanathan J; Haapasalo A; Bottcher C; Miettinen R; Kurkinen KMA; Lu A; Thomas A; Maynard CJ; Romano D; Hyman BT; Berezovska O; Bertram L; Soininen H; Dantuma NP; Tanzi RE; Hiltunen M
- Article: NATURE COMMUNICATIONS. 2011;2:191Heinen C; Acs K; Hoogstraten D; Dantuma NP
- Journal article: ALZHEIMERS & DEMENTIA. 2010;6(4S_Part_13):s396Haapasalo A; Viswanathan J; Böttcher C; Miettinen R; Kurkinen K; Maynard CJ; Lu A; Bertram L; Soininen H; Tanzi RE; Dantuma NP; Hiltunen M
- Article: FEBS LETTERS. 2010;584(8):1585-1590Heinen C; Garner TP; Long J; Bottcher C; Ralston SH; Cavey JR; Searle MS; Layfield R; Dantuma NP
- Article: JOURNAL OF NEUROSCIENCE. 2010;30(10):3675-3688Ortega Z; Diaz-Hernandez M; Maynard CJ; Hernandez F; Dantuma NP; Lucas JJ
- Article: AUTOPHAGY. 2010;6(2):217-227Tresse E; Salomons FA; Vesa J; Bott LC; Kimonis V; Yao T-P; Dantuma NP; Taylor JP
- Article: JOURNAL OF MOLECULAR BIOLOGY. 2009;394(4):732-746Beskow A; Grimberg KB; Bott LC; Salomons FA; Dantuma NP; Young P
- Article: JOURNAL OF CELL BIOLOGY. 2009;186(6):835-847Marteijn JA; Bekker-Jensen S; Mailand N; Lans H; Schwertman P; Gourdin AM; Dantuma NP; Lukas J; Vermeulen W
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(33):13986-13991Maynard CJ; Bottcher C; Ortega Z; Smith R; Florea BI; Diaz-Hernandez M; Brundin P; Overkleeft HS; Li J-Y; Lucas JJ; Dantuma NP
- Article: JOURNAL OF CELL BIOLOGY. 2009;185(4):577-586Luijsterburg MS; Dinant C; Lans H; Stap J; Wiernasz E; Lagerwerf S; Warmerdam DO; Lindh M; Brink MC; Dobrucki JW; Aten JA; Fousteri MI; Jansen G; Dantuma NP; Vermeulen W; Mullenders LHF; Houtsmuller AB; Verschure PJ; van Driel R
- Article: MOLECULAR AND CELLULAR BIOLOGY. 2009;29(7):1774-1785Salomons FA; Menendez-Benito V; Bottcher C; McCray BA; Taylor JP; Dantuma NP
- Article: FASEB JOURNAL. 2009;23(1):123-133Verhoef LGGC; Heinen C; Selivanova A; Halff EF; Salomons FA; Dantuma NP
- Article: HUMAN MOLECULAR GENETICS. 2009;18(1):82-96Cheroni C; Marino M; Tortarolo M; Veglianese P; De Biasi S; Fontana E; Zuccarello LV; Maynard CJ; Dantuma NP; Bendotti C
- Article: CANCER RESEARCH. 2007;67(20):10078-10086Zaman F; Menendez-Benito V; Eriksson E; Chagin AS; Takigawa M; Fadeel B; Dantuma NP; Chrysis D; Saevendahl L
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;357(4):1034-1039Selivanova A; Winblad B; Dantuma NP; Farmery MR
- Article: JOURNAL OF CELL SCIENCE. 2007;120(9):1615-1623van Tijn P; de Vrij FMS; Schuurman KG; Dantuma NP; Fischer DF; van Leeuwen FW; Hol EM
- Article: MOLECULAR CELL. 2007;26(2):175-188Kristiansen M; Deriziotis P; Dimcheff DE; Jackson GS; Ovaa H; Naumann H; Clarke AR; van Leeuwen FWB; Menendez-Benito V; Dantuma NP; Portis JL; Collinge J; Tabrizi SJ
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2006;350(1):220-226Selivanova A; Winblad B; Farmery MR; Dantuma NP; Ankarcrona M
- Article: CHEMISTRY AND BIOLOGY. 2006;13(11):1217-1226Verdoes M; Florea BI; Menendez-Benito V; Maynard CJ; Witte MD; van der Linden WA; van den Nieuwendijk AMCH; Hofmann T; Berkers CR; van Leeuwen FWB; Groothuis TA; Leeuwenburgh MA; Ovaa H; Neefjes JJ; Filippov DV; van der Marel GA; Dantuma NP; Overkleeft HS
- Article: CELL DIVISION. 2006;1:21Groothuis TAM; Dantuma NP; Neefjes J; Salomons FA
- Article: GENES & DEVELOPMENT. 2006;20(10):1343-1352Bergink S; Salomons FA; Hoogstraten D; Groothuis TAM; de Waard H; Wu J; Yuan L; Citterio E; Houtsmuller AB; Neefjes J; Hoeijmakers IHJ; Vermeulen W; Dantuma NP
- Article: JOURNAL OF CLINICAL VIROLOGY. 2006;36(1):50-59Majerová-Uhlíková T; Dantuma NP; Lindsten K; Masucci MG; Konvalinka J
- Article: JOURNAL OF CELL BIOLOGY. 2006;173(1):19-26Dantuma NP; Groothuis TAM; Salomons FA; Neefjes J
- Journal article: ESSAYS IN BIOCHEMISTRY. 2005;41:113-128Salomons FA; Verhoef LGGC; Dantuma NP
- Article: HUMAN MOLECULAR GENETICS. 2005;14(19):2787-2799Menéndez-Benito V; Verhoef LGGC; Masucci MG; Dantuma NP
- Article: MOLECULAR CELL. 2005;18(2):225-235Heessen S; Masucci MG; Dantuma NP
- Article: HUMAN MOLECULAR GENETICS. 2005;14(5):679-691Bowman AB; Yoo SY; Dantuma NP; Zoghbi HY
- Journal article: NEDERLANDS TIJDSCHRIFT VOOR GENEESKUNDE. 2004;148(52):2579-2582Neefjes J; Groothuis TAM; Dantuma NP
- Article: FEBS LETTERS. 2003;555(2):397-404Heessen S; Dantuma NP; Tessarz P; Jellne M; Masucci MG
- Article: NATURE BIOTECHNOLOGY. 2003;21(8):897-902Lindsten K; Menéndez-Benito V; Masucci MG; Dantuma NP
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(12):10013-10021Kessler B; Hong X; Petrovic J; Borodovsky A; Dantuma NP; Bogyo M; Overkleeft HS; Ploegh H; Glas R
- Article: SEMINARS IN CANCER BIOLOGY. 2003;13(1):69-76Dantuma NP; Masucci MG
- Article: HUMAN MOLECULAR GENETICS. 2002;11(22):2689-2700Verhoef LGGC; Lindsten K; Masucci MG; Dantuma NP
- Article: JOURNAL OF CELL BIOLOGY. 2002;157(3):417-427Lindsten K; de Vrij FMS; Verhoef LGGC; Fischer DF; van Leeuwen FW; Hol EM; Masucci MG; Dantuma NP
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(3):1532-1537Heessen S; Leonchiks A; Issaeva N; Sharipo A; Selivanova G; Masucci MG; Dantuma NP
- Article: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2001;45(9):2616-2622Lindsten K; Uhlíková T; Konvalinka J; Masucci MG; Dantuma NP
- Article: MOLECULAR CELL. 2001;7(2):411-420Myung J; Kim KB; Lindsten K; Dantuma NP; Crews CM
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2000;97(15):8381-8385Dantuma NP; Heessen S; Lindsten K; Jellne M; Masucci MG
- Article: NATURE BIOTECHNOLOGY. 2000;18(5):538-543Dantuma NP; Lindsten K; Glas R; Jellne M; Masucci MG
- Article: JOURNAL OF LIPID RESEARCH. 1999;40(5):973-978Dantuma NP; Potters M; De Winther MPJ; Tensen CP; Kooiman FP; Bogerd J; Van der Horst DJ
- Article: JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY. 1998;46(9):1085-1089Dantuma NP; Pijnenburg MAP; Diederen JHB; Van der Horst DJ
- Article: JOURNAL OF LIPID RESEARCH. 1998;39(9):1877-1888Dantuma NP; Pijnenburg MAP; Diederen JHB; Van der Horst DJ
- Article: JOURNAL OF LIPID RESEARCH. 1997;38(2):254-265Dantuma NP; Pijnenburg MAP; Diederen JHB; VanderHorst DJ
- Article: JOURNAL OF LIPID RESEARCH. 1996;37(6):1345-1355Dantuma NP; VanMarrewijk WJA; Wynne HJ; VanderHorst DJ
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Alla övriga publikationer
- Preprint: BIORXIV. 2025Gierisch ME; Barchi E; Marogna M; Wallnöfer MH; Ankarcrona M; Naia L; Salomons FA; Dantuma NP
- Preprint: BIORXIV. 2024Xu S; Gierisch M; Barchi E; Poser I; Alberti S; Salomons F; Dantuma N
- Editorial comment: NEURAL REGENERATION RESEARCH. 2024;19(2):403-404Xu S; Dantuma NP
- Editorial comment: COMMUNICATIONS BIOLOGY. 2021;4(1):919Garcia-Saura AG; Herzog LK; Dantuma NP; Schuler H
- Review: AUTOPHAGY. 2021;17(1):1-382Klionsky DJ; Abdel-Aziz AK; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; Abildgaard MH; Abudu YP; Acevedo-Arozena A; Adamopoulos IE; Adeli K; Adolph TE; Adornetto A; Aflaki E; Agam G; Agarwal A; Aggarwal BB; Agnello M; Agostinis P; Agrewala JN; Agrotis A; Aguilar PV; Ahmad ST; Ahmed ZM; Ahumada-Castro U; Aits S; Aizawa S; Akkoc Y; Akoumianaki T; Akpinar HA; Al-Abd AM; Al-Akra L; Al-Gharaibeh A; Alaoui-Jamali MA; Alberti S; Alcocer-Gomez E; Alessandri C; Ali M; Al-Bari MAA; Aliwaini S; Alizadeh J; Almacellas E; Almasan A; Alonso A; Alonso GD; Altan-Bonnet N; Altieri DC; Alves S; da Costa CA; Alzaharna MM; Amadio M; Amantini C; Amaral C; Ambrosio S; Amer AO; Ammanathan V; An Z; Andersen SU; Andrabi SA; Andrade-Silva M; Andres AM; Angelini S; Ann D; Anozie UC; Ansari MY; Antas P; Antebi A; Anton Z; Anwar T; Apetoh L; Apostolova N; Araki T; Araki Y; Arasaki K; Araujo WL; Araya J; Arden C; Arevalo M-A; Arguelles S; Arias E; Arikkath J; Arimoto H; Ariosa AR; Armstrong-James D; Arnaune-Pelloquin L; Aroca A; Arroyo DS; Arsov I; Artero R; Asaro DML; Aschner M; Ashrafizadeh M; Ashur-Fabian O; Atanasov AG; Au AK; Auberger P; Auner HW; Aurelian L; Autelli R; Avagliano L; Avalos Y; Aveic S; Aveleira CA; AvinWittenberg T; Aydin Y; Ayton S; Ayyadevara S; Azzopardi M; Baba M; Backer JM; Backues SK; Bae D-H; Bae O-N; Bae SH; Baehrecke EH; Baek A; Baek S-H; Baek SH; Bagetta G; Bagniewska-Zadworna A; Bai H; Bai J; Bai X; Bai Y; Bairagi N; Baksi S; Balbi T; Baldari CT; Balduini W; Ballabio A; Ballester M; Balazadeh S; Balzan R; Bandopadhyay R; Banerjee S; Banerjee S; Bao Y; Baptista MS; Baracca A; Barbati C; Bargiela A; Barila D; Barlow PG; Barmada SJ; Barreiro E; Barreto GE; Bartek J; Bartel B; Bartolome A; Barve GR; Basagoudanavar SH; Bassham DC; Bast RCJ; Basu A; Batoko H; Batten I; Baulieu EE; Baumgarner BL; Bayry J; Beale R; Beau I; Beaumatin F; Bechara LRG; Beck GRJ; Beers MF; Begun J; Behrends C; Behrens GMN; Bei R; Bejarano E; Bel S; Behl C; Belaid A; Belgareh-Touze N; Bellarosa C; Belleudi F; Bello Perez M; Bello-Morales R; de Oliveira Beltran JS; Beltran S; Benbrook DM; Bendorius M; Benitez BA; Benito-Cuesta I; Bensalem J; Berchtold MW; Berezowska S; Bergamaschi D; Bergami M; Bergmann A; Berliocchi L; Berlioz-Torrent C; Bernard A; Berthoux L; Besirli CG; Besteiro S; Betin VM; Beyaert R; Bezbradica JS; Bhaskar K; Bhatia-Kissova I; Bhattacharya R; Bhattacharya S; Bhattacharyya S; Bhuiyan MS; Bhutia SK; Bi L; Bi X; Biden TJ; Bijian K; Billes VA; Binart N; Bincoletto C; Birgisdottir AB; Bjorkoy G; Blanco G; Blas-Garcia A; Blasiak J; Blomgran R; Blomgren K; Blum JS; Boada-Romero E; Boban M; BoeszeBattaglia K; Boeuf P; Boland B; Bomont P; Bonaldo P; Bonam SR; Bonfili L; Bonifacino JS; Boone BA; Bootman MD; Bordi M; Borner C; Bornhauser BC; Borthakur G; Bosch J; Bose S; Botana LM; Botas J; Boulanger CM; Boulton ME; Bourdenx M; Bourgeois B; Bourke NM; Bousquet G; Boya P; Bozhkov PV; Bozi LHM; Bozkurt TO; Brackney DE; Brandts CH; Braun RJ; Braus GH; Bravo-Sagua R; Bravo-San Pedro JM; Brest P; Bringer M-A; Briones-Herrera A; Broaddus VC; Brodersen P; Alvarez EMC; Brodsky JL; Brody SL; Bronson PG; Bronstein JM; Brown CN; Brown RE; Brum PC; Brumell JH; Brunetti-Pierri N; Bruno D; Bryson-Richardson RJ; Bucci C; Buchrieser C; Bueno M; Buitrago-Molina LE; Buraschi S; Buch S; Buchan JR; Buckingham EM; Budak H; Budini M; Bultynck G; Burada F; Burgoyne JR; Buron MI; Bustos V; Buttner S; Butturini E; Byrd A; Cabas I; Cabrera-Benitez S; Cadwell K; Cai J; Cai L; Cai Q; Cairo M; Calbet JA; Caldwell GA; Caldwell KA; Call JA; Calvani R; Calvo AC; Barrera MC-R; Camara NO; Camonis JH; Camougrand N; Campanella M; Campbell EM; Campbell-Valois F-X; Campello S; Campesi I; Campos JC; Camuzard O; Cancino J; de Almeida DC; Canesi L; Caniggia I; Canonico B; Canti C; Cao B; Caraglia M; Carames B; Carchman EH; Cardenal-Munoz E; Cardenas C; Cardenas L; Cardoso SM; Carew JS; Carle GF; Carleton G; Carloni S; Carmona-Gutierrez D; Carneiro LA; Carnevali O; Carosi JM; Carra S; Carrier A; Carrier L; Carroll B; Carter AB; Carvalho AN; Casanova M; Casas C; Casas J; Cassioli C; Castillo EF; Castillo K; Castillo-Lluva S; Castoldi F; Castori M; Castro AF; Castro-Caldas M; Castro-Hernandez J; Castro-Obregon S; Catz SD; Cavadas C; Cavaliere F; Cavallini G; Cavinato M; Cayuela ML; Rica PC; Cecarini V; Cecconi F; Cechowska-Pasko M; Cenci S; Ceperuelo-Mallafre V; Cerqueira JJ; Cerutti JM; Cervia D; Cetintas VB; Cetrullo S; Chae H-J; Chagin AS; Chai C-Y; Chakrabarti G; Chakrabarti O; Chakraborty T; Chakraborty T; Chami M; Chamilos G; Chan DW; Chan EYW; Chan ED; Chan HYE; Chan HH; Chan H; Chan MTV; Chan YS; Chandra PK; Chang C-P; Chang C; Chang H-C; Chang K; Chao J; Chapman T; Charlet-Berguerand N; Chatterjee S; Chaube SK; Chaudhary A; Chauhan S; Chaum E; Checler F; Cheetham ME; Chen C; Chen G-C; Chen J-F; Chen LL; Chen L; Chen L; Chen M; Chen M; Chen N; Chen Q; Chen R-H; Chen S; Chen W; Chen W; Chen X; Chen X-W; Chen X; Chen Y; Chen Y-G; Chen Y; Chen Y; Chen Y; Chen Y-Q; Chen ZS; Chen Z; Chen Z-H; Chen ZJ; Chen Z; Cheng H; Cheng J; Cheng S-Y; Cheng W; Cheng X; Cheng X-T; Cheng Y; Cheng Z; Chen Z; Cheong H; Cheong JK; Chernyak BV; Cherry S; Cheung CFR; Cheung CHA; Cheung K-H; Chevet E; Chi RJ; Chiang AKS; Chiaradonna F; Chiarelli R; Chiariello M; Chica N; Chiocca S; Chiong M; Chiou S-H; Chiramel AI; Chiurchiu V; Cho D-H; Choe S-K; Choi AMK; Choi ME; Choudhury KR; Chow NS; Chu CT; Chua JP; Chua JJE; Chung H; Chung KP; Chung S; Chung S-H; Chung Y-L; Cianfanelli V; Ciechomska IA; Cifuentes M; Cinque L; Cirak S; Cirone M; Clague MJ; Clarke R; Clementi E; Coccia EM; Codogno P; Cohen E; Cohen MM; Colasanti T; Colasuonno F; Colbert RA; Colell A; Coll NS; Collins MO; Colombo MI; Colon-Ramos DA; Combaret L; Comincini S; Cominetti MR; Consiglio A; Conte A; Conti F; Contu VR; Cookson MR; Coombs KM; Coppens I; Corasaniti MT; Corkery DP; Cordes N; Cortese K; Costa MDC; Costantino S; Costelli P; Coto-Montes A; Crack PJ; Crespo JL; Criollo A; Crippa V; Cristofani R; Csizmadia T; Cuadrado A; Cui B; Cui J; Cui Y; Cui Y; Culetto E; Cumino AC; Cybulsky AV; Czaja MJ; Czuczwar SJ; D'Adamo S; D'Amelio M; D'Arcangelo D; D'Lugos AC; D'Orazi G; da Silva JA; Dafsari HS; Dagda RK; Dagdas Y; Daglia M; Dai X; Dai Y; Dai Y; Dal Col J; Dalhaimer P; Dalla Valle L; Dallenga T; Dalmasso G; Damme M; Dando I; Dantuma NP; Darling AL; Das H; Dasarathy S; Dasari SK; Dash S; Daumke O; Dauphinee AN; Davies JS; Davila VA; Davis RJ; Davis T; Naidu SD; De Amicis F; De Bosscher K; De Felice F; De Franceschi L; De Leonibus C; de Mattos Barbosa MG; De Meyer GRY; De Milito A; De Nunzio C; De Palma C; De Santi M; De Virgilio C; De Zio D; Debnath J; DeBosch BJ; Decuypere J; Deehan MA; Deflorian G; DeGregori J; Dehay B; Del Rio G; Delaney JR; Delbridge LMD; Delorme-Axford E; Delpino MV; Demarchi F; Dembitz V; Demers ND; Deng H; Deng Z; Dengjel J; Dent P; Denton D; DePamphilis ML; Der CJ; Deretic V; Descoteaux A; Devis L; Devkota S; Devuyst O; Dewson G; Dharmasivam M; 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Emre NCT; Eng CH; Engedal N; Engelbrecht A-M; Engelsen AST; Enserink JM; Escalante R; Esclatine A; Escobar-Henriques M; Eskelinen E-L; Espert L; Eusebio M-O; Fabrias G; Fabrizi C; Facchiano A; Facchiano F; Fadeel B; Fader C; Faesen AC; Fairlie WD; Falco A; Falkenburger BH; Fan D; Fan J; Fan Y; Fang EF; Fang Y; Fang Y; Fanto M; Farfel-Becker T; Faure M; Fazeli G; Fedele AO; Feldman AM; Feng D; Feng J; Feng L; Feng Y; Feng Y; Feng W; Araujo TF; Ferguson TA; Fernandez-Checa JC; FernandezVeledo S; Fernie AR; Ferrante AWJ; Ferraresi A; Ferrari MF; Ferreira JCB; Ferro-Novick S; Figueras A; Filadi R; Filigheddu N; FilippiChiela E; Filomeni G; Fimia GM; Fineschi V; Finetti F; Finkbeiner S; Fisher EA; Fisher PB; Flamigni F; Fliesler SJ; Flo TH; Florance I; Florey O; Florio T; Fodor E; Follo C; Fon EA; Forlino A; Fornai F; Fortini P; Fracassi A; Fraldi A; Franco B; Franco R; Franconi F; Frankel LB; Friedman SL; Frohlich LF; Fruhbeck G; Fuentes JM; Fujiki Y; Fujita N; Fujiwara Y; Fukuda M; Fulda S; 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- Review: FRONTIERS IN CHEMISTRY. 2020;8:64Gierisch ME; Giovannucci TA; Dantuma NP
- Editorial comment: TRENDS IN BIOCHEMICAL SCIENCES. 2019;44(5):383-387Dissmeyer N; Coux O; Rodriguez MS; Barrio R; Core Group Members of PROTEOSTASIS
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- Review: FRONTIERS IN GENETICS. 2016;7:58Dantuma NP; Pfeiffer A
- Review: EMBO JOURNAL. 2016;35(1):6-23Dantuma NP; van Attikum H
- Review: EXPERIMENTAL CELL RESEARCH. 2014;329(1):9-17Dantuma NP; Acs K; Luijsterburg MS
- Conference publication: JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY. 2014;85:A14-A15Rauen M; Christensen K; Thirstrup K; Dantuma N; Norremolle A; Dachsel J; Fog K
- Review: FRONTIERS IN MOLECULAR NEUROSCIENCE. 2014;7:70Dantuma NP; Bott LC
- Review: TRENDS IN CELL BIOLOGY. 2012;22(9):483-491Dantuma NP; Hoppe T
- Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1289-1295Salomons FA; Acs K; Dantuma NP
- Review: CARDIOVASCULAR RESEARCH. 2010;85(2):263-271Dantuma NP; Lindsten K
- Review: DNA REPAIR. 2009;8(4):449-460Dantuma NP; Heinen C; Hoogstraten D
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- Review: ESSAYS IN BIOCHEMISTRY. 2005;41:113-128Salomons FA; Verhoef LGGC; Dantuma NP
- Review: RECOMBINANT PROTEIN EXPRESSION: PROKARYOTIC HOSTS AND CELL-FREE SYSTEMS. 2005;399:490-511Menéndez-Benito V; Heessen S; Dantuma NP
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- Review: FEBS LETTERS. 2002;529(1):22-26Dantuma NP; Masucci MG
- Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S516Lindsten K; Verhoef LGGC; Masucci MG; Dantuma N; de Vrij FMS; Fischer DF; van Leeuwen FW; Hol EM
- Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2002;269:23-36Dantuma NP; Sharipo A; Masucci MG
- Letter: NATURE BIOTECHNOLOGY. 2000;18(8):807Masucci MG; Dantuma NP
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Forskningsbidrag
- Swedish Research Council1 January 2025 - 31 December 2027The removal of misfolded or otherwise damaged proteins from the intracellular environment is of critical importance for cells as these aberrant proteins can give rise to toxic protein aggregates. The main proteolytic mechanism for the destruction of misfolded proteins is the ubiquitin-proteasome system (UPS), which is a central player in cellular protein quality control. The UPS is a complex machinery involving hundreds of different proteins, many of which have distinct enzymatic activities and are, therefore, potentially druggable targets. In recent years, both inhibition and stimulation of the UPS have gained credit as means for therapeutic intervention in human diseases. Malignant cells typically produce high levels of misfolded proteins, which render them exquisitely sensitive to drugs that inhibit UPS activity. On the other hand, stimulation of the UPS may prevent the accumulation of aggregation-prone proteins in neurons, which plays a central role in a variety of age-related, neurodegenerative disorders, such as Alzheimer’s disease. We have previously established tools for the monitoring of UPS activity in normal and malignant cells and started a drug discovery campaign for UPS inhibitors. Here we propose 1) to study the mode of action of a novel inhibitor of the UPS with anti-tumor properties, 2) explore the potential of two cellular targets for stimulating the UPS and 3) inveistigate the status of the UPS in human embryonic stem cell-derived neuronal lineages.
- Hjärnfonden1 July 2023 - 30 June 2025
- Swedish Research Council1 January 2022 - 31 December 2024
- Target identification of a novel inhibitor of the ubiquitin-proteasome system and autophagyNovo Nordisk Foundation1 April 2020 - 31 March 2021
- In vivo validation of a novel inhibitor of the ubiquitin/proteasome systemNovo Nordisk Foundation1 August 2019 - 31 July 2020
- Development of ubiquitin inhibitors for cancer treatmentSwedish Cancer Society1 January 2018A dysfunctional protein degradation plays an important role in cancer. Marking proteins with ubiquitin is central to protein degradation as it stimulates specific protein degradation. Ubiquitin is also important for a cell's ability to repair DNA damage. Many anti-cancer therapies are based on causing DNA damage in tumor cells and since tumor cells are often incapable of repairing DNA damage, such treatment mostly selectively targets cancer cells. Substances that inhibit the function of the ubiquitin in protein degradation and DNA repair can be used to kill the cancer cells. In this project, we plan to investigate two topics that we have identified in screens for their potential to slow down protein degradation. We have seen that these substances are toxic to the cancer cells. Our goal is to understand how they kill cancer cells and to study their activity in a mouse model. In another project, we have identified an enzyme which removes ubiquitin from proteins that act as key players in the regulation of repairing DNA damage. We want to develop substances that slow down ubiquitin-dependent processes, to drugs that block protein breakage in various ways or slow down the ability of cells to repair DNA damage. Blocking protein breakdown is a relatively new strategy for anti-cancer therapy. So far, there is only one approved anti-cancer drug that works this way, it has been used for several years to treat multiple myeloma.
- Deutsche Forschungsgemeinschaft1 January 2018 - 31 December 2021
- Deutsche Forschungsgemeinschaft1 January 2018 - 31 December 2021
- Development of ubiquitin inhibitors for cancer treatmentSwedish Cancer Society1 January 2017A dysfunctional protein degradation plays an important role in cancer. Marking proteins with ubiquitin is central to protein degradation as it stimulates specific protein degradation. Ubiquitin is also important for a cell's ability to repair DNA damage. Many anti-cancer therapies are based on causing DNA damage in tumor cells and since tumor cells are often incapable of repairing DNA damage, such treatment mostly selectively targets cancer cells. Substances that inhibit the function of the ubiquitin in protein degradation and DNA repair can be used to kill the cancer cells. In this project, we plan to investigate two topics that we have identified in screens for their potential to slow down protein degradation. We have seen that these substances are toxic to the cancer cells. Our goal is to understand how they kill cancer cells and to study their activity in a mouse model. In another project, we have identified an enzyme which removes ubiquitin from proteins that act as key players in the regulation of repairing DNA damage. We want to develop substances that slow down this enzyme because we have seen that the tumor cells become extremely sensitive to irradiation and so-called PARP inhibitors when they lack the enzyme. We want to develop substances that slow down ubiquitin-dependent processes, to drugs that block protein breakage in various ways or slow down the ability of cells to repair DNA damage. Blocking protein breakdown is a relatively new strategy for anti-cancer therapy. So far, there is only one approved anti-cancer drug that works this way, it has been used for several years to treat multiple myeloma.
- Swedish Research Council1 January 2017 - 31 December 2020
- Swiss National Science Foundation1 April 2016 - 31 March 2019
- Development of ubiquitin inhibitors for cancer treatmentSwedish Cancer Society1 January 2016A dysfunctional protein degradation plays an important role in cancer. Marking proteins with ubiquitin is central to protein degradation as it stimulates specific protein degradation. Ubiquitin is also important for a cell's ability to repair DNA damage. Many anti-cancer therapies are based on causing DNA damage in tumor cells and since tumor cells are often incapable of repairing DNA damage, such treatment mostly selectively targets cancer cells. Substances that inhibit the function of the ubiquitin in protein degradation and DNA repair can be used to kill the cancer cells. In this project, we plan to investigate two topics that we have identified in screens for their potential to slow down protein degradation. We have seen that these substances are toxic to the cancer cells. Our goal is to understand how they kill cancer cells and to study their activity in a mouse model. In another project, we have identified an enzyme which removes ubiquitin from proteins that act as key players in the regulation of repairing DNA damage. We want to develop substances that slow down this enzyme because we have seen that the tumor cells become extremely sensitive to irradiation and so-called PARP inhibitors when they lack the enzyme. We want to develop substances that slow down ubiquitin-dependent processes, to drugs that block protein breakage in various ways or slow down the ability of cells to repair DNA damage. Blocking protein breakdown is a relatively new strategy for anti-cancer therapy. So far, there is only one approved anti-cancer drug that works this way, it has been used for several years to treat multiple myeloma.
- Swedish Research Council1 January 2016 - 31 December 2016
- Swedish Research Council1 December 2015 - 30 November 2018
- Development of ubiquitin inhibitors for cancer treatmentSwedish Cancer Society1 January 2015A dysfunctional protein degradation plays an important role in cancer. Marking proteins with ubiquitin is central to protein degradation as it stimulates specific protein degradation. Ubiquitin is also important for a cell's ability to repair DNA damage. Many anti-cancer therapies are based on causing DNA damage in tumor cells and since tumor cells are often incapable of repairing DNA damage, such treatment mostly selectively targets cancer cells. Substances that inhibit the function of the ubiquitin in protein degradation and DNA repair can be used to kill the cancer cells. In this project, we plan to investigate two topics that we have identified in screens for their potential to slow down protein degradation. We have seen that these substances are toxic to the cancer cells. Our goal is to understand how they kill cancer cells and to study their activity in a mouse model. In another project, we have identified an enzyme which removes ubiquitin from proteins that act as key players in the regulation of repairing DNA damage. We want to develop substances that slow down this enzyme because we have seen that the tumor cells become extremely sensitive to irradiation and so-called PARP inhibitors when they lack the enzyme. We want to develop substances that slow down ubiquitin-dependent processes, to drugs that block protein breakage in various ways or slow down the ability of cells to repair DNA damage. Blocking protein breakdown is a relatively new strategy for anti-cancer therapy. So far, there is only one approved anti-cancer drug that works this way, it has been used for several years to treat multiple myeloma.
- Study in the importance of protein degradation for cancerSwedish Cancer Society1 January 2014A dysfunctional protein degradation plays an important role in cancer. Marking of proteins with ubiquitin is central to protein degradation because the ubiquitin marks proteins for direct degradation. Ubiquitin is also important for a cell's ability to repair DNA damage. Many anti-cancer therapies are based on causing DNA damage in tumor cells. Because tumor cells are often incapable of repairing DNA damage, such treatment mostly selectively targets cancer cells. In this project, we plan to investigate the role of ubiquitin in repairing DNA damage. By studying with microscopy various proteins that are involved in repairing DNA damage in cells, we will study the importance of ubiquitin and protein degradation in the defense of the cells against DNA damage. We have also developed a test to screen large collections of chemicals to try to find potential drugs that can block the intracellular protein degradation. We want to achieve a better knowledge of how ubiquitin affects the repair of DNA damage. Which proteins are marked with ubiquitin when cells are exposed to DNA damage, how does the marker occur and leads it to protein degradation? We want to use our screen to find drugs that block nebulization in different ways. Blocking protein breakdown is a relatively new strategy for anti-cancer therapy. So far, there is only one approved anti-cancer drug that works this way, it has been used for several years to treat multiple myeloma.
- Swedish Research Council1 January 2013 - 31 December 2015
- Swedish Research Council1 January 2013 - 31 December 2016
- Swedish Research Council1 January 2010 - 31 December 2012
Anställningar
- Professor, Cell- och molekylärbiologi, Karolinska Institutet, 2011-
Examina och utbildning
- Docent, Cellbiologi, Karolinska Institutet, 2009
Priser och utmärkelser
- Eric K. Fernström Award, Annual price for young promising scientist awarded by the Fernström foundation. [‘... for his pioniering studies on the mechanisms for protein degradation. Of special importance is his discovery of domains that protect from degradation, so-called stabilization signals…..’], 2009
- The Svedberg Award, Annual price for young researcher by the Swedish Society for Biochemistry and Molecular Biology and the National Committee for Molecular Biosciences, managed by the Royal Swedish Academy of Sciences. ‘… for his significant contribution into understanding of the mechanisms behind protein degradation and their importance for nerve degeneration.’, Royal Swedish Academy of Sciences, 2007