Michael Yi Bonner
E-postadress: michael.yi.bonner@ki.se
Besöksadress: Solnavägen 9, 3A, 17177 Stockholm
Postadress: C2 Medicinsk biokemi och biofysik, 171 77 Stockholm
Om mig
- My long-term goal is to become an academic investigator and establish my own
research group, which will focus on advancing our understanding of cancer
biology. In the short term, I am focused on cultivating the necessary skills,
knowledge, and networks that will help me succeed. The laboratory of Prof.
Jack L. Arbiser, MD, PhD, a pupil of the late Judah Folkman, MD, has a long
history developing small molecules as antiangiogenic and antitumor therapies.
The lab has both discovered natural products and synthesized novel small
molecules. I have spent the past ten years learning the scientific techniques
used in his research. Prior to joining the Arbiser group, I obtained a BA
degree in Chemistry at Emory University, and I have since assisted in the
discovery of the antiangiogenic and/ in vivo/ antitumor properties of
honokiol, a natural product from the Magnolia tree. I have also synthesized
honokiol analogs. In addition, I have helped synthesize and test Imipramine
Blue, a novel NADPH oxidase inhibitor with systemic availability and
antitumor efficacy. I have helped pioneer a novel synthesis of Solenopsin A
(ant venom) and Solenopsin A analogs, which has been demonstrated to act as
ceramide analogs with tumor suppressive activity. Finally, I have helped
reveal the antitumor properties of palladium complexes, including Tris DBA
Palladium, for clinical development.
My previous experience with the Arbiser group has given me broad knowledge in
biochemistry, cancer biology, and organic chemical synthesis focused towards
pre-clinical therapeutic research. Most importantly, it has given me the
poise and skills to pursue a professional education and career as an
independent academic scientist. Currently I have co-authored a number of
peer-reviewed publications, a testament to my dedication to scientific
scholarship.
I have since joined Prof. Rikard Holmdahl’s group at the Karolinska
Institute in Stockholm, Sweden as a PhD candidate. I have found a Thesis
project entitled "*Redox Modulation- Impact on Tumor Growth & Therapeutic
Anticancer Efficacy"* that expands on my experience in angiogenesis and
cancer biology, as well as offer new opportunities to further develop in
Redox biology, immunology, and proteomics.
*2022 Robert Lundberg Memorial Foundation*
The purpose of the foundation is to promote scientific research in the field
of tumour diseases, especially cancer.
*2018 SWIMM Travel Award*
Swedish Society of Immunology SWIMM
SWIMM is a part of the Scandinavian Society for Immunology (SSI), which also
comprises of the Danish, Finnish, Norwegian and Icelandic National Societies.
The main goal for the society is to assemble immunologists in Sweden and work
for the progress of basic and applied immunology. SSI award travel grants to
applicants who fulfill our eligibility criteria.
https://swimm.se/ [1]
*2017 Ruth L. Kirschstein Predoctoral Individual National Research Service
Award (4 years + 1 year)*
NIH: National Cancer Institute
The purpose of the Kirschstein-NRSA program is to enable promising
predoctoral students with potential to develop into a productive, independent
research scientists, to obtain mentored research training while conducting
dissertation research.
https://www.cancer.gov/about-nci/budget/fact-book/extramural-programs/nrsa
[1] https://swimm.se/
Forskningsbeskrivning
- My current project focuses on changes in the REDOX environment of leukocytes
that stem from the Nox2 complex in murine cancer models. Specifically, I am
focused on understanding how murine cancer models develop slower in mice
carrying mutations in the Ncf1 (p47-phox) gene, a key component of the Nox2
complex controlling for production of superoxide /hydrogen peroxide in
leukocytes which is also mutated in approximately 23% of patients diagnosed
with chronic granulomatous disease (CGD).
Artiklar
- Article: ANTIOXIDANTS. 2021;11(1):12Aoun M; Cai X; Xu B; Lahore GF; Bonner MY; He Y; Backdahl L; Holmdahl R
- Article: JOURNAL OF SURGICAL RESEARCH. 2021;264:544-552Cai X; Tian Y; Wu Y; Bonner MY; Zhuo X; Yuan Z
- Journal article: CANCERS. 2021;13(9):2015da Costa A; Bonner MY; Rao S; Gilbert L; Sasaki M; Elsey J; MacKelfresh J; Arbiser JL
- Article: NATURE COMMUNICATIONS. 2021;12(1):610Norin U; Rintisch C; Meng L; Forster F; Ekman D; Tuncel J; Klocke K; Backlund J; Yang M; Bonner MY; Lahore GF; James J; Shchetynsky K; Bergquist M; Gjertsson I; Hubner N; Backdahl L; Holmdahl R
- Journal article: JOURNAL OF IMMUNOLOGY. 2020;204(1_Supplement):242.46Bonner MY; Olofsson P; Holmdahl R
- Article: CANCERS. 2020;12(2):E395-395da Costa A; Bonner MY; Rao S; Gilbert L; Sasaki M; Elsey J; MacKelfresh J; Arbiser JL
- Article: ONCOTARGET. 2019;10(43):4424-4436Musi E; Schwartz GK; Yoo JH; Odelberg SJ; Li DY; Bonner MY; Selvakumar P; Rao S; Gilbert LC; Elsey J; Arbiser JL
- Article: ONCOGENE. 2017;36(41):5709-5721Sengupta S; Nagalingam A; Muniraj N; Bonner MY; Mistriotis P; Afthinos A; Kuppusamy P; Lanoue D; Cho S; Korangath P; Shriver M; Begum A; Merino VF; Huang C-Y; Arbiser JL; Matsui W; Gyorffy B; Konstantopoulos K; Sukumar S; Marignani PA; Saxena NK; Sharma D
- Article: SCIENTIFIC REPORTS. 2017;7(1):11198Arbiser JL; Nowak R; Michaels K; Skabytska Y; Biedermann T; Lewis MJ; Bonner MY; Rao S; Gilbert LC; Yusuf N; Karlsson I; Fritz Y; Ward NL
- Journal article: JAMA DERMATOLOGY. 2017;153(9):931-932Costa A; Mackelfresh J; Gilbert L; Bonner MY; Arbiser JL
- Article: CLINICAL AND EXPERIMENTAL DERMATOLOGY. 2017;42(6):645-647da Costa A; Bonner M; Arbiser JL
- Article: INTERNATIONAL JOURNAL OF DERMATOLOGY. 2017;56(7):754-761Costa A; Facchini G; Pinheiro ALTA; da Silva MS; Bonner MY; Arbiser J; Eberlin S
- Journal article: BREAST CANCER RESEARCH. 2017;19(1):39Nagalingam A; Arbiser JL; Bonner MY; Saxena NK; Sharma D
- Article: ONCOTARGET. 2016;7(43):69321-69336Akamata K; Wei J; Bhattacharyya M; Cheresh P; Bonner MY; Arbiser JL; Raparia K; Gupta MP; Kamp DW; Varga J
- Article: ONCOTARGET. 2016;7(32):51651-51664Laidlaw KME; Berhan S; Liu S; Silvestri G; Holyoake TL; Frank DA; Aggarwal B; Bonner MY; Perrotti D; Jorgensen HG; Arbiser JL
- Article: ONCOTARGET. 2016;7(32):51569-51580Diaz B; Ostapoff KT; Toombs JE; Lo J; Bonner MY; Curatolo A; Adsay V; Brekken RA; Arbiser JL
- Article: MOLECULES. 2016;21(8):E995-995Medra A; Witkowska M; Majchrzak A; Cebula-Obrzut B; Bonner MY; Robak T; Arbiser JL; Smolewski P
- Article: EXPERIMENTAL DERMATOLOGY. 2016;25(6):479-480Tuberculosis verrucosa cutis lesions exhibit a greater microvessel count than lupus vulgaris lesionsBhandarkar SS; Lanka P; Lanka LR; Veledar E; Bonner MY; MacKelfresh J; Arbiser JL
- Article: ONCOTARGET. 2016;7(11):12857-12868Bonner MY; Karlsson I; Rodolfo M; Arnold RS; Vergani E; Arbiser JL
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(3):564-566Arbiser JL; Bonner MY
- Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(3):561-564Strid J; McLean WHI; Irvine AD
- Article: ONCOTARGET. 2015;6(30):29947-29962Avtanski DB; Nagalingam A; Bonner MY; Arbiser JL; Saxena NK; Sharma D
- Article: ONCOTARGET. 2015;6(18):16396-16410Avtanski DB; Nagalingam A; Kuppusamy P; Bonner MY; Arbiser JL; Saxena NK; Sharma D
- Article: NATURE COMMUNICATIONS. 2015;6:6656Pillai VB; Samant S; Sundaresan NR; Raghuraman H; Kim G; Bonner MY; Arbiser JL; Walker DI; Jones DP; Gius D; Gupta MP
- Article: RADIATION RESEARCH. 2015;183(3):262-270Weyemi U; Redon CE; Aziz T; Choudhuri R; Maeda D; Parekh PR; Bonner MY; Arbiser JL; Bonner WM
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(7):2121-2126Weyemi U; Redon CE; Aziz T; Choudhuri R; Maeda D; Parekh PR; Bonner MY; Arbiser JL; Bonner WM
- Article: VASCULAR CELL. 2015;7:5Karlsson I; Zhou X; Thomas R; Smith AT; Bonner MY; Bakshi P; Banga AK; Bowen JP; Qabaja G; Ford SL; Ballard MD; Petersen KS; Li X; Chen G; Ogretmen B; Zhang J; Watkins EB; Arnold RS; Arbiser JL
- Article: MOLECULAR ONCOLOGY. 2014;8(3):565-580Autanski DB; Nagalingam A; Bonner MY; Arbiser JL; Saxena NK; Sharma D
- Article: PROSTATE. 2014;74(4):408-420Hahm E-R; Karlsson AI; Bonner MY; Arbiser JL; Singh SV
- Article: PLOS ONE. 2014;9(2):e86369Wang X; Beitler JJ; Wang H; Lee MJ; Huang W; Koenig L; Nannapaneni S; Amin ARMR; Bonner M; Shin HJC; Chen ZG; Arbiser JL; Shin DM
- Journal article: JAMA DERMATOLOGY. 2013;149(8):991-992Spence-Shishido A; Carr C; Bonner MY; Arbiser JL
- Article: BRITISH JOURNAL OF CANCER. 2013;109(2):433-443Martin S; Lamb HK; Brady C; Lefkove B; Bonner MY; Thompson P; Lovat PE; Arbiser JL; Hawkins AR; Redfern CPF
- Article: CELL CYCLE. 2013;12(14):2200-2209Munson J; Bonner M; Fried L; Hofmekler J; Arbiser J; Bellamkonda R
- Journal article: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2012;67(2):e81-e83Arbiser JL; Bips M; Seidler A; Bonner MY; Kovach C
- Article: VASCULAR CELL. 2012;4(1):11Govindarajan B; Willoughby L; Band H; Curatolo AS; Veledar E; Chen S; Bonner MY; Abel M-G; Moses MA; Arbiser JL
- Article: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(127):127ra36Munson JM; Fried L; Rowson SA; Bonner MY; Karumbaiah L; Diaz B; Courtneidge SA; Knaus UG; Brat DJ; Arbiser JL; Bellamkonda RV
- Article: BREAST CANCER RESEARCH. 2012;14(1):R35Nagalingam A; Arbiser JL; Bonner MY; Saxena NK; Sharma D
- Article: JOURNAL OF UROLOGY. 2012;187(1):296-301Abbasi A; Johnson TV; Kleris R; Ying K; Bonner MY; Maithel SK; Kooby DA; Marshall FF; Master VA
- Journal article: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2011;64(1):200-201Bartus C; Brown LF; Bonner MY; Arbiser JL
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(8):2359-2365Bhandarkar SS; Jaconi M; Fried LE; Bonner MY; Lefkove B; Govindarajan B; Perry BN; Parhar R; Mackelfresh J; Sohn A; Stouffs M; Knaus U; Yancopoulos G; Reiss Y; Benest AV; Augustin HG; Arbiser JL
- Journal article: ARCHIVES OF DERMATOLOGY. 2009;145(5):587-588Arbiser JL; Bonner MY
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Alla övriga publikationer
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2020;140(7):S114Costa A; Teichmann M; Bonner M; Mackelfresh J; Gilbert L; Rao S; Arbiser J
- Conference publication: JOURNAL OF IMMUNOLOGY. 2020;204(1)Bonner MY; Olofsson P; Holmdahl R
- Published conference paper: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2018;1862(11):2518-2527Selenium unmasks protective iron armor: A possible defense against cutaneous inflammation and cancerArbiser JL; Bonner MY; Ward N; Elsey J; Rao S
- Review: NPJ PRECISION ONCOLOGY. 2017;1:23Arbiser JL; Bonner MY; Gilbert LC
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017;137(5):S18Bonner M; Pankove R; Rao S; Costa A; Shetata B; Elsey J; Arbiser JL
- Review: AMERICAN JOURNAL OF CLINICAL DERMATOLOGY. 2016;17(4):369-385Costa A; Bonner MY; Arbiser JL
- Meeting abstract: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(5):S19da Costa A; Govindarajan B; Bonner MY; Rao S; Arbiser J
- Conference publication: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. 2016;74(5):AB27Costa A; Clerici SP; Facchini G; Pinheiro A; Bonner MY; Arbiser J; Eberlin S
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135:S85Arbiser JL; Michaels KA; Nowak RS; Bonner M; Karlsson I; Fritz Y; Ward NL
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135:S31Bhandarkar S; Lanka P; Lanka LR; Bonner M; Mackelfresh J; Arbiser JL
- Meeting abstract: CANCER RESEARCH. 2014;74(19):lb-61-lb-61Sengupta S; Bonner MY; Arbiser JL; Saxena NK; Sharma D
- Meeting abstract: CANCER RESEARCH. 2014;74(19):lb-187-lb-187Avtanski DB; Bonner MY; Tiutan TP; Arbiser JL; Saxena NK; Sharma D
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2014;134:S125Bonner M; Karlsson I; Rodolfo M; Arnold RS; Vergani E; Arbiser J
- Review: FUTURE MEDICINAL CHEMISTRY. 2014;6(12):1413-1422Bonner MY; Arbiser JL
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2013;133:S252Karlsson I; Bonner MY; Zhou X; Zhang J; Watkins EB; Bowen JP; Arbiser JL
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2012;69(14):2435-2442Bonner MY; Arbiser JL
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132:S26Arbiser JL; Bonner MY; Cerulli R; Liu S; Frank DA
- Meeting abstract: CANCER RESEARCH. 2012;72:153Nagalingam A; Arbiser JL; Bonner MY; Saxena N; Sharma D
- Conference publication: BLOOD. 2011;118(21):723Smolewski P; Jeske A; Majchrzak A; Cebula B; Bonner MY; Arbiser JL; Robak T
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131:S16Berrios RL; Martin-Garrido A; Bonner MY; Pollack BP; Arbiser JL
- Conference publication: JOURNAL OF UROLOGY. 2011;185(4):E708-E709Abbasi A; Johnson T; Kleris R; Ying K; Bonner M; Maithel S; Kooby D; Master V
- Conference publication: CANCER RESEARCH. 2010;70:3702Munson JM; Bonner M; Karumbaiah L; Arbiser J; Bellamkonda R
- Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2010;130:S2Chua R; Souza L; McLemore A; Bonner MY; Cohen C; Arbsier JL
- Review: CURRENT MOLECULAR MEDICINE. 2009;9(8):929-934Arbiser JL; Bonner MY; Berrios RL
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