Marie Arsenian-Henriksson

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Marie Arsenian Henriksson blev professor i molekylär tumörbiologi vid Karolinska Institutet 2010. Sedan mars 2023 är hon också KI:s vicerektor för forskning. Hon har tidigare varit prefekt för institutionen för mikrobiologi, tumör- och cellbiologi (2006-2016), lärarrepresentant i konsistoriet (2019-2021) och är även ledamot i KI:s rekryteringsnämnd sedan 2021.

Forskningsbeskrivning

Marie Arsenian Henrikssons forskning fokuserar på de så kallade MYC-generna, som är aktiverade i minst en tredjedel av alla cancerformer, inklusive lymfom, bröstcancer och neuroblastom. Neuroblastom är den barncancer som har störst dödlighet näst efter leukemi, och där amplifiering av MYCN-genen (N står för neuro) har samband med en sämre prognos.

Forskningen kring MYC-generna syftar till ökad kunskap om hur dessa gener fungerar under normala förhållanden respektive bidrar till utveckling av tumörsjukdomar. Kunskap som är viktigt för utveckling av nya, skräddarsydda cancerbehandlingar.

Artiklar

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2025;122(25):e2427211122
Combined targeting of PRDX6 and GSTP1 as a potential differentiation strategy for neuroblastoma treatment
Liano-Pons J; Garde-Lapido E; Fahrig FL; Jackering M; Yuan Y; Andersson S; Schort L; Esteve M; Mohlin S; Bedoya-Reina OC; Arsenian-Henriksson M
Article: MOLECULAR PHARMACEUTICS. 2025;22(6):3479-3490
Engineered Peptide Coacervates Enable Efficient Intracellular Delivery of the MYC Inhibitor omoMYC
Cerrato CP; Krkoska M; Sun Y; Liano-Pons J; Neo QY; Vosselman T; Alzrigat M; Vojtesek B; Lane DP; Henriksson MA; Miserez A; Landreh M
Article: ADVANCED FUNCTIONAL MATERIALS. 2025;35(22)
Sustained Release of Proteins Using Region-Specific Tunable Degradability in Hydrogels through 3D Photopatterning and Complimentary Labile Bond Chemistry
Kivijarvi T; Cerrato CP; Kohlan TB; O'Callaghan P; Kreuger J; Arsenian-Henriksson M; Finne-Wistrand A
Article: NEURO-ONCOLOGY. 2024;26(12):2174-2192
Defining neuroblastoma: From origin to precision medicine
Sainero-Alcolado L; Bexelius TS; Santopolo G; Yuan Y; Liano-Pons J; Arsenian-Henriksson M
Article: CELL DEATH & DISEASE. 2024;15(11):836
EZH2 inhibition sensitizes retinoic acid-driven senescence in synovial sarcoma
Mushtaq M; Liano-Pons J; Wang J; Alzrigat M; Yuan Y; Ruiz-Perez MV; Chen Y; Kashuba E; de Flon FH; Brodin B; Arsenian-Henriksson M
Article: STRUCTURE. 2024;32(11):2160-2167.e2
AlphaFold with conformational sampling reveals the structural landscape of homorepeats
Bonet ADF; Ranyai S; Aswad L; Lane DP; Arsenian-Henriksson M; Landreh M; Lama D
Article: SCIENCE ADVANCES. 2024;10(25):eado1583
MOXD1 is a lineage-specific gene and a tumor suppressor in neuroblastoma
Fredlund E; Andersson S; Hilgert E; Monferrer E; alvarez-Hernan G; Karakaya S; Loontiens S; Bek JW; Gregor T; Lecomte E; Magnusson E; Miltenyte E; Cabirol M; Kyknas M; Engstroem N; Henriksson MA; Hammarlund E; Rosenblum JS; Noguera R; Speleman F; van Nes J; Mohlin S
Article: CANCER RESEARCH COMMUNICATIONS. 2024;4(3):691-705
Drug-resilient Cancer Cell Phenotype Is Acquired via Polyploidization Associated with Early Stress Response Coupled to HIF2α Transcriptional Regulation
Carroll C; Manaprasertsak A; Boffelli Castro A; van den Bos H; Spierings DCJ; Wardenaar R; Bukkuri A; Engstrom N; Baratchart E; Yang M; Biloglav A; Cornwallis CK; Johansson B; Hagerling C; Arsenian-Henriksson M; Paulsson K; Amend SR; Mohlin S; Foijer F; Mcintyre A; Pienta KJ; Hammarlund EU
Article: NATURE COMMUNICATIONS. 2024;15(1):1865
A druggable conformational switch in the c-MYC transactivation domain
Lama D; Vosselman T; Sahin C; Liano-Pons J; Cerrato CP; Nilsson L; Teilum K; Lane DP; Landreh M; Arsenian Henriksson M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2024;121(7):e2310479121
Targeting MYC induces lipid droplet accumulation by upregulation of HILPDA in clear cell renal cell carcinoma
Sainero-Alcolado L; Garde-Lapido E; Snaebjornsson MT; Schoch S; Stevens I; Ruiz-Perez MV; Dyrager C; Pelechano V; Axelson H; Schulze A; Arsenian-Henriksson M
Article: SCIENCE ADVANCES. 2023;9(41):eadg5109
Coinhibition of topoisomerase 1 and BRD4-mediated pause release selectively kills pancreatic cancer via readthrough transcription
Cameron DP; Grosser J; Ladigan S; Kuzin V; Iliopoulou E; Wiegard A; Benredjem H; Jackson K; Liffers ST; Lueong S; Cheung PF; Vangala D; Pohl M; Viebahn R; Teschendorf C; Wolters H; Usta S; Geng K; Kutter C; Arsenian-Henriksson M; Siveke JT; Tannapfel A; Schmiegel W; Hahn SA; Baranello L
Article: CANCERS. 2023;15(18):4599
Target Genes of c-MYC and MYCN with Prognostic Power in Neuroblastoma Exhibit Different Expressions during Sympathoadrenal Development
Yuan Y; Alzrigat M; Rodriguez-Garcia A; Wang X; Bexelius TS; Johnsen JI; Arsenian-Henriksson M; Liano-Pons J; Bedoya-Reina OC
Article: NANOMEDICINE. 2023;18(18):1161-1173
Organ uptake, toxicity and skin clearance of ruthenium contrast agents monitored in vivo by x-ray fluorescence
Vogt C; Saladino GM; Shaker K; Arsenian-Henriksson M; Hertz HM; Toprak MS; Brodin BA
Article: ANALYTICAL CHEMISTRY. 2023;95(29):10869-10872
Monitoring Disassembly and Cargo Release of Phase-Separated Peptide Coacervates with Native Mass Spectrometry
Cerrato CPP; Leppert A; Sun Y; Lane DPP; Arsenian-Henriksson M; Miserez A; Landreh M
Article: PNAS NEXUS. 2023;2(2):pgac303
A "grappling hook" interaction connects self-assembly and chaperone activity of Nucleophosmin 1
Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmae M; Chen G; Elofsson A; Allison TM; Arsenian-Henriksson M; Johansson J; Lane DP; Hallberg BM; Landreh M
Article: NANOSCALE. 2023;15(5):2214-2222
XFCT-MRI hybrid multimodal contrast agents for complementary imaging
Saladino GM; Vogt C; Brodin B; Shaker K; Kilic NI; Andersson K; Arsenian-Henriksson M; Toprak MS; Hertz HM
Article: SCIENTIFIC REPORTS. 2023;13(1):1273
Metabolic rewiring in MYC-driven medulloblastoma by BET-bromodomain inhibition
Graziani V; Garcia AR; Alcolado LS; Le Guennec A; Henriksson MA; Conte MRR
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2022;41(1):226
Expression and activation of nuclear hormone receptors result in neuronal differentiation and favorable prognosis in neuroblastoma
Sainero-Alcolado L; Mushtaq M; Liano-Pons J; Rodriguez-Garcia A; Yuan Y; Liu T; Ruiz-Perez MV; Schlisio S; Bedoya-Reina O; Arsenian-Henriksson M
Article: NATURE METABOLISM. 2022;4(6):739-758
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Article: STRUCTURE. 2022;30(5):733-742.e7
A "spindle and thread"mechanism unblocks p53 translation N-terminal disorder
Kaldmae M; Vosselman T; Zhong X; Lama D; Chen G; Saluri M; Kronqvist N; Siau JW; Ng AS; Ghadessy FJ; Sabatier P; Vojtesek B; Sarr M; Sahin C; Osterlund N; Ilag LL; Vaananen VA; Sedimbi S; Arsenian-Henriksson M; Zubarev RA; Nilsson L; Koeck PJB; Rising A; Abelein A; Fritz N; Johansson J; Lane DP; Landreh M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(6):e2102358119
Epigenetic state determines inflammatory sensing in neuroblastoma
Wolpaw AJ; Grossmann LD; Dessau JL; Dong MM; Aaron BJ; Brafford PA; Volgina D; Pascual-Pasto G; Rodriguez-Garcia A; Uzun Y; Arsenian-Henriksson M; Powell DJJ; Bosse KR; Kossenkov A; Tan K; Hogarty MD; Maris JM; Dang CV
Article: COMMUNICATIONS PHYSICS. 2021;4(1):259
Phase-contrast X-ray tomography resolves the terminal bronchioles in free-breathing mice
Shaker K; Haggmark I; Reichmann J; Arsenian-Henriksson M; Hertz HM
Article: CHEMPHOTOCHEM. 2021;5(7):632-643
Photophysical Characteristics of Polarity-Sensitive and Lipid Droplet-Specific Phenylbenzothiadiazoles
Colas K; Doloczki S; Kesidou A; Sainero-Alcolado L; Rodriguez-Garcia A; Arsenian-Henriksson M; Dyrager C
Article: ISCIENCE. 2021;24(5):102494
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance
Zhang J; Teran G; Popa M; Madapura H; Ladds MJGW; Lianoudaki D; Grunler J; Arsenian-Henriksson M; McCormack E; Rottenberg ME; Catrina S-B; Lain S; Darekar S
Article: BMC BIOLOGY. 2021;19(1):57
Neuronal cell-based high-throughput screen for enhancers of mitochondrial function reveals luteolin as a modulator of mitochondria-endoplasmic reticulum coupling
Naia L; Pinho CM; Dentoni G; Liu J; Leal NS; Ferreira DMS; Schreiner B; Filadi R; Fao L; Connolly NMC; Forsell P; Nordvall G; Shimozawa M; Greotti E; Basso E; Theurey P; Gioran A; Joselin A; Arsenian-Henriksson M; Nilsson P; Rego AC; Ruas JL; Park D; Bano D; Pizzo P; Prehn JHM; Ankarcrona M
Article: ISCIENCE. 2021;24(2):102128
Inhibition of fatty acid synthesis induces differentiation and reduces tumor burden in childhood neuroblastoma
Victoria Ruiz-Perez M; Sainero-Alcolado L; Oliynyk G; Matuschek I; Balboni N; Ubhayasekera SJKA; Snaebjornsson MT; Makowski K; Aaltonen K; Bexell D; Serra D; Nilsson R; Bergquist J; Schulze A; Arsenian-Henriksson M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(50):32005-32016
Targeting a scavenger receptor on tumor-associated macrophages activates tumor cell killing by natural killer cells
Eisinger S; Sarhan D; Boura VF; Ibarlucea-Benitez I; Tyystjarvi S; Oliynyk G; Arsenian-Henriksson M; Lane D; Wikstrom SL; Kiessling R; Virgilio T; Gonzalez SF; Kaczynska D; Kanatani S; Daskalaki E; Wheelock CE; Sedimbi S; Chambers BJ; Ravetch JV; Karlsson MCI
Article: IEEE TRANSACTIONS ON MEDICAL IMAGING. 2020;39(12):3910-3919
Longitudinal In-Vivo X-Ray Fluorescence Computed Tomography With Molybdenum Nanoparticles
Shaker K; Vogt C; Katsu-Jimenez Y; Kuiper RV; Andersson K; Li Y; Larsson JC; Rodriguez-Garcia A; Toprak MS; Arsenian-Henriksson M; Hertz HM
Article: FASEB JOURNAL. 2020;34(8):10818-10834
The chromatin-remodeling complexes B-WICH and NuRD regulate ribosomal transcription in response to glucose
Rolicka A; Guo Y; Ganez Zapater A; Tariq K; Quin J; Vintermist A; Sadeghifar F; Arsenian-Henriksson M; Ostlund Farrants A-K
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(27):15673-15683
Cell stemness is maintained upon concurrent expression of RB and the mitochondrial ribosomal protein S18-2
Mushtaq M; Kovalevska L; Darekar S; Abramsson A; Zetterberg H; Kashuba V; Klein G; Arsenian-Henriksson M; Kashuba E
Journal article: CANCER IMMUNOLOGY RESEARCH. 2020;8(4_Supplement):b09
Abstract B09: Targeting scavenger receptors for immunotherapy of cancer
Boura VF; Tyystjärvi S; Oliynyk G; Arsenian-Henriksson M; Karlsson MCI; Sohn S
Article: CELL DEATH & DISEASE. 2020;11(1):52
p53 controls genomic stability and temporal differentiation of human neural stem cells and affects neural organization in human brain organoids
Navarro AM; Pronk RJ; van der Geest AT; Oliynyk G; Nordgren A; Arsenian-Henriksson M; Falk A; Wilhelm M
Article: NATURE COMMUNICATIONS. 2020;11(1):71
Integrative discovery of treatments for high-risk neuroblastoma
Almstedt E; Elgendy R; Hekmati N; Rosen E; Warn C; Olsen TK; Dyberg C; Doroszko M; Larsson I; Sundstrom A; Henriksson MA; Pahlman S; Bexell D; Vanlandewijck M; Kogner P; Jornsten R; Krona C; Nelander S
Article: ISCIENCE. 2019;21:188-204
MYCN-enhanced Oxidative and Glycolytic Metabolism Reveals Vulnerabilities for Targeting Neuroblastoma
Oliynyk G; Ruiz-Perez MV; Sainero-Alcolado L; Dzieran J; Zirath H; Gallart-Ayala H; Wheelock CE; Johansson HJ; Nilsson R; Lehtio J; Arsenian-Henriksson M
Article: IMMUNITY. 2019;51(1):169-184.e5
Single-Cell RNA Sequencing of the T Helper Cell Response to House Dust Mites Defines a Distinct Gene Expression Signature in Airway Th2 Cells
Tibbitt CA; Stark JM; Martens L; Ma J; Mold JE; Deswarte K; Oliynyk G; Feng X; Lambrecht BN; De Bleser P; Nylen S; Hammad H; Henriksson MA; Saeys Y; Coquet JM
Article: PHYSICS IN MEDICINE AND BIOLOGY. 2018;63(16):164001
High-spatial-resolution x-ray fluorescence tomography with spectrally matched nanoparticles
Larsson JC; Vogt C; Vagberg W; Toprak MS; Dzieran J; Arsenian-Henriksson M; Hertz HM
Journal article: MICROSCOPY AND MICROANALYSIS. 2018;24(S2):82-83
Laboratory Nanoparticle X-Ray Fluorescence Tomography for High-Resolution Small-Animal Imaging
Larsson JC; Vogt C; Vagberg W; Toprak MS; Dzieran J; Arsenian-Henriksson M; Hertz HM
Article: NATURE COMMUNICATIONS. 2018;9(1):1107
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Farnegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(6):E1229-E1238
MYCN-amplified neuroblastoma maintains an aggressive and undifferentiated phenotype by deregulation of estrogen and NGF signaling
Dzieran J; Garcia AR; Westermark UK; Henley AB; Sanchez EE; Trager C; Johansson HJ; Lehtio J; Arsenian-Henriksson M
Article: SCIENTIFIC REPORTS. 2017;7(1):10274
Neuroblastoma patient-derived xenograft cells cultured in stem-cell promoting medium retain tumorigenic and metastatic capacities but differentiate in serum
Persson CU; von Stedingk K; Bexell D; Merselius M; Braekeveldt N; Gisselsson D; Arsenian-Henriksson M; Pahlman S; Wigerup C
Article: GENES & DEVELOPMENT. 2017;31(10):1036-1053
Neuroblast differentiation during development and in neuroblastoma requires KIF1Bβ-mediated transport of TRKA
Fell SM; Li S; Wallis K; Kock A; Surova O; Rraklli V; Hoefig CS; Li W; Mittag J; Henriksson MA; Kenchappa RS; Holmberg J; Kogner P; Schlisio S
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2016;136(12):2485-2494
MicroRNA-203 Inversely Correlates with Differentiation Grade, Targets c-MYC, and Functions as a Tumor Suppressor in cSCC
Lohcharoenkal W; Harada M; Loven J; Meisgen F; Landen NX; Zhang L; Lapins J; Das Mahapatra K; Shi H; Nissinen L; Kahari V-M; Stahle M; Sonkoly E; Grander D; Arsenian-Henriksson M; Pivarcsi A
Article: JOURNAL OF NEUROSCIENCE. 2016;36(40):10425-10439
Proliferation and Survival of Embryonic Sympathetic Neuroblasts by MYCN and Activated ALK Signaling
Kramer M; Ribeiro D; Arsenian-Henriksson M; Deller T; Rohrer H
Article: CELL REPORTS. 2016;16(4):979-993
Regulation of Nuclear Hormone Receptors by MYCN-Driven miRNAs Impacts Neural Differentiation and Survival in Neuroblastoma Patients
Ribeiro D; Klarqvist MDR; Westermark UK; Oliynyk G; Dzieran J; Kock A; Banares CS; Hertwig F; Johnsen JI; Fischer M; Kogner P; Loven J; Henriksson MA
Article: ONCOTARGET. 2015;6(32):32380-32395
Direct inhibition of c-Myc-Max heterodimers by celastrol and celastrol-inspired triterpenoids
Wang H; Teriete P; Hu A; Raveendra-Panickar D; Pendelton K; Lazo JS; Eiseman J; Holien T; Misund K; Oliynyk G; Arsenian-Henriksson M; Cosford NDP; Sundan A; Prochownik EV
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(26):8070-8075
COX/mPGES-1/PGE₂ pathway depicts an inflammatory-dependent high-risk neuroblastoma subset
Larsson K; Kock A; Idborg H; Henriksson MA; Martinsson T; Johnsen JI; Korotkova M; Kogner P; Jakobsson P-J
Article: VIROLOGY. 2015;476:271-288
Acetylation of the c-MYC oncoprotein is required for cooperation with the HTLV-1 p30^II accessory protein and the induction of oncogenic cellular transformation by p30^II/c-MYC
Romeo MM; Ko B; Kim J; Brady R; Heatley HC; He J; Harrod CK; Barnett B; Ratner L; Lairmore MD; Martinez E; Luescher B; Robson CN; Henriksson M; Harrod R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(1):220-225
TAp73 suppresses tumor angiogenesis through repression of proangiogenic cytokines and HIF-1α activity
Stantic M; Sakil HAM; Zirath H; Fang T; Sanz G; Fernandez-Woodbridge A; Marin A; Susanto E; Mak TW; Henriksson MA; Wilhelm MT
Article: PHYSICS IN MEDICINE AND BIOLOGY. 2014;59(11):2801-2811
X-ray phase contrast with injected gas for tumor microangiography
Lundstrom U; Westermark UK; Larsson DH; Burvall A; Henriksson MA; Hertz HM
Article: PLOS ONE. 2014;9(5):e97285
Targeting of the MYCN Protein with Small Molecule c-MYC Inhibitors
Muller I; Larsson K; Frenzel A; Oliynyk G; Zirath H; Prochownik EV; Westwood NJ; Henriksson MA
Article: EMBO REPORTS. 2014;15(4):383-391
MYC proteins promote neuronal differentiation by controlling the mode of progenitor cell division
Zinin N; Adameyko I; Wilhelm M; Fritz N; Uhlen P; Ernfors P; Henriksson MA
Article: EXPERIMENTAL CELL RESEARCH. 2013;319(20):3160-3169
Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus leavis oocytes
Wahlstrom T; Belikov S; Henriksson MA
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2013;110(25):10258-10263
MYC inhibition induces metabolic changes leading to accumulation of lipid droplets in tumor cells
Zirath H; Frenzel A; Oliynyk G; Segerstrom L; Westermark UK; Larsson K; Persson MM; Hultenby K; Lehtio J; Einvik C; Pahlman S; Kogner P; Jakobsson P-J; Henriksson MA
Article: MEDICAL PHYSICS. 2013;40(2):021909
First application of liquid-metal-jet sources for small-animal imaging: High-resolution CT and phase-contrast tumor demarcation
Larsson DH; Lundstrom U; Westermark UK; Henriksson MA; Burvall A; Hertz HM
Article: PHYSICS IN MEDICINE AND BIOLOGY. 2012;57(22):7431-7441
X-ray phase-contrast CO₂ angiography for sub-10 μm vessel imaging
Lundstrom U; Larsson DH; Burvall A; Scott L; Westermark UK; Wilhelm M; Henriksson MA; Hertz HM
Article: ONCOGENESIS. 2012;1(3):e3
MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma
Sonkoly E; Loven J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grander D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Stahle M; Pivarcsi A
Article: PLOS ONE. 2011;6(11):e27988
Identification of Cytotoxic Drugs That Selectively Target Tumor Cells with MYC Overexpression
Frenzel A; Zirath H; Vita M; Albihn A; Henriksson MA
Article: GENES AND CANCER. 2010;1(6):660-667
Targeting MYC-Regulated miRNAs to Combat Cancer.
Frenzel A; Lovén J; Henriksson MA
Article: GENES & DEVELOPMENT. 2010;24(6):549-560
Isoform-specific p73 knockout mice reveal a novel role for ΔNp73 in the DNA damage response pathway
Wilhelm MT; Rufini A; Wetzel MK; Tsuchihara K; Inoue S; Tomasini R; Itie-Youten A; Wakeham A; Arsenian-Henriksson M; Melino G; Kaplan DR; Miller FD; Mak TW
Article: ONCOGENE. 2010;29(4):503-515
Chromosomal rearrangements after ex vivo Epstein-Barr virus (EBV) infection of human B cells
Lacoste S; Wiechec E; Silva AGDS; Guffei A; Williams G; Lowbeer M; Benedek K; Henriksson M; Klein G; Mai S
Article: PLOS ONE. 2010;5(1):e8924
Myc Is Required for Activation of the ATM-Dependent Checkpoints in Response to DNA Damage
Guerra L; Albihn A; Tronnersjo S; Yan Q; Guidi R; Stenerlow B; Sterzenbach T; Josenhans C; Fox JG; Schauer DB; Thelestam M; Larsson L-G; Henriksson M; Frisan T
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(4):1553-1558
MYCN-regulated microRNAs repress estrogen receptor-α (ESR1) expression and neuronal differentiation in human neuroblastoma
Loven J; Zinin N; Wahlstrom T; Muller I; Brodin P; Fredlund E; Ribacke U; Pivarcsi A; Pahlman S; Henriksson M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(1):58-63
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
Hydbring P; Bahram F; Su Y; Tronnersjo S; Hogstrand K; von der Lehr N; Sharifi HR; Lilischkis R; Hein N; Wu S; Vervoorts J; Henriksson M; Grandien A; Luscher B; Larsson L-G
Article: EXPERIMENTAL CELL RESEARCH. 2009;315(17):2941-2952
DLEU2, frequently deleted in malignancy, functions as a critical host gene of the cell cycle inhibitory microRNAs miR-15a and miR-16-1
Lerner M; Harada M; Loven J; Castro J; Davis Z; Oscier D; Henriksson M; Sangfelt O; Grander D; Corcoran MM
Article: BIOCHEMISTRY-MOSCOW. 2008;73(11):1260-1268
Identification of recognition sites for Myc/Max/Mxd network proteins by a whole human chromosome 19 selection strategy
Akopov SB; Chernov IP; Wahlstrom T; Kostina MB; Klein G; Henriksson M; Nikolaev LG
Article: ONCOGENE. 2008;27(20):2910-2922
Inhibitors of mammalian target of rapamycin downregulate MYCN protein expression and inhibit neuroblastoma growth in vitro and in vivo
Johnsen JI; Segerstrom L; Orrego A; Elfman L; Henriksson M; Kagedal B; Eksborg S; Sveinbjornsson B; Kogner P
Article: LEUKEMIA RESEARCH. 2008;32(2):297-307
Role of Myc in differentiation and apoptosis in HL60 cells after exposure to arsenic trioxide or all-trans retinoic acid
Jiang G; Albihn A; Tang T; Tian Z; Henriksson M
Article: INTERNATIONAL JOURNAL OF CANCER. 2007;121(8):1821-1829
Camptothecin-induced apoptosis is enhanced by Myc and involves PKCdelta signaling
Albihn A; Mo H; Yang Y; Henriksson M
Article: BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION. 2007;35(3):187-192
Open-ended assignments and student responsibility
Brauner A; Carey J; Henriksson M; Sunnerhagen M; Ehrenborg E
Article: CELL CYCLE. 2006;5(19):2191-2194
Myc overexpression enhances apoptosis induced by small molecules
Mo H; Vita M; Crespin M; Henriksson M
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2006;98(6):1597-1614
c-Myc-dependent etoposide-induced apoptosis involves activation of Bax and caspases, and PKCdelta signaling
Albihn A; Loven J; Ohlsson J; Osorio LM; Henriksson M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(16):6344-6349
Identification of small molecules that induce apoptosis in a Myc-dependent manner and inhibit Myc-driven transformation
Mo H; Henriksson M
Article: ONCOGENE. 2005;24(56):8326-8337
Mnt transcriptional repressor is functionally regulated during cell cycle progression
Popov N; Wahlström T; Hurlin PJ; Henriksson M
Article: CANCER RESEARCH. 2005;65(4):1361-1368
Mitotic infidelity and centrosome duplication errors in cells overexpressing tripeptidyl-peptidase II
Stavropoulou V; Xie JJ; Henriksson M; Tomkinson B; Imreh S; Masucci MG
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;323(3):750-759
Biophysical properties of regions flanking the bHLH-Zip motif in the p22 Max protein
Pursglove SE; Fladvad M; Bellanda M; Moshref A; Henriksson M; Carey J; Sunnerhagen M
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2004;92(6):1282-1295
Expression and DNA-binding activity of MYCN/max and Mnt/max during induced differentiation of human neuroblastoma cells
Smith AG; Popov N; Imreh M; Axelson H; Henriksson M
Article: CELL DEATH AND DIFFERENTIATION. 2003;10(12):1320-1328
The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B
Cartier A; Broberg E; Komai T; Henriksson M; Masucci MG
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(13):11094-11099
The Mad and Myc basic domains are functionally equivalent
Nikiforov MA; Popov N; Kotenko I; Henriksson M; Cole MD
Article: EXPERIMENTAL CELL RESEARCH. 2002;274(1):25-34
The histone deacetylase inhibitor trichostatin a derepresses the telomerase reverse transcriptase (hTERT) gene in human cells
Hou M; Wang XB; Popov N; Zhang AJ; Zhao XY; Zhou R; Zetterberg A; Björkholm M; Henriksson M; Gruber A; Xu DW
Article: ONCOGENE. 2002;21(3):447-459
Repression of in vivo growth of Myc/Ras transformed tumor cells by Mad1
Cerni C; Skrzypek B; Popov N; Sasgary S; Schmidt G; Larsson LG; Lüscher B; Henriksson M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;290(1):11-15
c-myc suppression in Burkitt's lymphoma cells
Simonsson T; Henriksson M
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2001;19(4):773-777
Differential expression of class IHDACs:: Roles of cell density and cell cycle
Dangond F; Henriksson M; Zardo G; Caiafa P; Ekström TJ; Gray SG
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(11):6407-6411
Horizontal transfer of oncogenes by uptake of apoptotic bodies
Bergsmedh A; Szeles A; Henriksson M; Bratt A; Folkman MJ; Spetz AL; Holmgren L
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(7):3826-3831
Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells
Xu DW; Popov N; Hou M; Wang Q; Björkholm M; Gruber A; Menkel AR; Henriksson M
Article: APOPTOSIS. 2001;6(1-2):133-137
Inactivation of Myc-induced p53-dependent apoptosis in human tumors
Henriksson M; Selivanova G; Lindström M; Wiman KG
Article: CANCER RESEARCH. 2000;60(22):6230-6235
Frequent amplification of the Telomerase Reverse Transcriptase gene in human tumors
Zhang AJ; Zheng CY; Lindvall C; Hou M; Ekedahl J; Lewensohn R; Yan ZQ; Yang XY; Henriksson M; Blennow E; Nordenskjöld M; Zetterberg A; Björkholm M; Gruber A; Xu DW
Article: EXPERIMENTAL CELL RESEARCH. 2000;260(1):61-72
Inhibition of cell growth and apoptosis by inducible expression of the transcriptional repressor Mad1
Bejarano MT; Albihn A; Cornvik T; Brijker SO; Asker C; Osorio LM; Henriksson M
Article: ONCOGENE. 1999;18(41):5620-5630
Interaction of the fork head domain transcription factor MPP2 with the human papilloma virus 16 E7 protein:: enhancement of transformation and transactivation
Lüscher-Firzlaff JM; Westendorf JM; Zwicker J; Burkhardt H; Henriksson M; Müller R; Pirollet F; Lüscher B
Article: EUROPEAN JOURNAL OF CANCER. 1995;31A(12):2099-2104
The amino-terminal phosphorylation sites of C-MYC are frequently mutated in Burkitt's lymphoma lines but not in mouse plasmacytomas and rat immunocytomas
Axelson H; Henriksson M; Wang Y; Magnusson KP; Klein G
Article: ONCOGENE. 1995;11(3):587-596
DIFFERENTIAL-EFFECTS BY MAD AND MAX ON TRANSFORMATION BY CELLULAR AND VIRAL ONCOPROTEINS
CERNI C; BOUSSET K; SEELOS C; BURKHARDT H; HENRIKSSON M; LUSCHER B
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Review: PNAS NEXUS. 2025;4(5):pgaf152
Conformational modulation of intrinsically disordered transactivation domains for cancer therapy
Vosselman T; Sahin C; Lane DP; Henriksson MA; Landreh M; Lama D
Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):5019
Publisher Correction: A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage (vol 14, 5019, 2023)
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Faernegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Preprint: RESEARCH SQUARE. 2023
EZH2 inhibition sensitizes retinoic acid-driven senescence in Synovial sarcoma
Mushtaq M; Liaño-Pons J; Yuan Y; Ruiz-Pérez MV; Kashuba E; Brodin B; Arsenian-Henriksson M
Corrigendum: NATURE METABOLISM. 2022;4(10):1421
Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel-Lindau syndrome (June, 10.1038/s42255-022-00593-x, 2022)
Li S; Li W; Yuan J; Bullova P; Wu J; Zhang X; Liu Y; Plescher M; Rodriguez J; Bedoya-Reina OC; Jannig PR; Valente-Silva P; Yu M; Henriksson MA; Zubarev RA; Smed-Sorensen A; Suzuki CK; Ruas JL; Holmberg J; Larsson C; Christofer Juhlin C; von Kriegsheim A; Cao Y; Schlisio S
Preprint: BIORXIV. 2022
A “grappling hook” interaction balances self-assembly and chaperone activity of Nucleophosmin 1
Saluri M; Leppert A; Gese GV; Sahin C; Lama D; Kaldmäe M; Chen G; Elofsson A; Allison T; Arsenian-Henriksson M; Johansson J; Lane D; Hällberg M; Landreh M
Review: CELL DEATH AND DIFFERENTIATION. 2022;29(7):1304-1317
Targeting mitochondrial metabolism for precision medicine in cancer
Sainero-Alcolado L; Liano-Pons J; Ruiz-Perez MV; Arsenian-Henriksson M
Review: CANCERS. 2021;13(18):4682
The Multiple Faces of MNT and Its Role as a MYC Modulator
Liano-Pons J; Arsenian-Henriksson M; Leon J
Conference publication: 2021;:58
Preclinical in vivo x-ray fluorescence computed tomography
Shaker K; Vogt C; Katsu-Jimenéz Y; Kuiper RV; Andersson K; Li Y; Larsson JC; Rodriguez-Garcia A; Toprak MS; Arsenian-Henriksson M; Hertz HM
Editorial comment: CANCER RESEARCH. 2019;79(15):3818-3819
Serine-Glycine-One-Carbon Metabolism: The Hidden Achilles Heel of MYCN-Amplified Neuroblastoma?
Garcia AR; Arsenian-Henriksson M
Corrigendum: NATURE COMMUNICATIONS. 2018;9(1):2071
A DHODH inhibitor increases p53 synthesis and enhances tumor cell killing by p53 degradation blockage
Ladds MJGW; van Leeuwen IMM; Drummond CJ; Chu S; Healy AR; Popova G; Fernandez AP; Mollick T; Darekar S; Sedimbi SK; Nekulova M; Sachweh MCC; Campbell J; Higgins M; Tuck C; Popa M; Safont MM; Gelebart P; Fandalyuk Z; Thompson AM; Svensson R; Gustavsson A-L; Johansson L; Farnegardh K; Yngve U; Saleh A; Haraldsson M; D'Hollander ACA; Franco M; Zhao Y; Hakansson M; Walse B; Larsson K; Peat EM; Pelechano V; Lunec J; Vojtesek B; Carmena M; Earnshaw WC; McCarthy AR; Westwood NJ; Arsenian-Henriksson M; Lane DP; Bhatia R; McCormack E; Lain S
Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(5):E1532-1532
Fibroblasts in the Tumor Microenvironment: Shield or Spear?
Alkasalias T; Moyano-Galceran L; Arsenian-Henriksson M; Lehti K
Review: GENES. 2017;8(4):E113-113
The MYCN Protein in Health and Disease
Ruiz-Perez MV; Henley AB; Arsenian-Henriksson M
Review: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1849(5):563-569
Impact of MYC in regulation of tumor cell metabolism
Wahlstrom T; Henriksson MA
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2011;21(4):215-216
Neuroblastoma research progress - A 2011 perspective
Henriksson MA; Pahlman S
Review: SEMINARS IN CANCER BIOLOGY. 2011;21(4):256-266
The MYCN oncogene and differentiation in neuroblastoma
Westermark UK; Wilhelm M; Frenzel A; Henriksson MA
Review: EXPERIMENTAL CELL RESEARCH. 2010;316(8):1429-1437
The Yin and Yang functions of the Myc oncoprotein in cancer development and as targets for therapy
Larsson L-G; Henriksson MA
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2010;107:163-224
MYC in Oncogenesis and as a Target for Cancer Therapies
Albihn A; Johnsen JI; Henriksson MA
Review: APOPTOSIS. 2009;14(4):424-438
Embryonal neural tumours and cell death
Johnsen JI; Kogner P; Albihn A; Henriksson MA
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 2007;97:61-80
Mnt takes control as key regulator of the Myc/Max/Mxd network
Wahlstrom T; Henriksson M
Editorial comment: SEMINARS IN CANCER BIOLOGY. 2006;16(4):241
25 years of the c-Myc oncogene
Cole MD; Henriksson M
Review: SEMINARS IN CANCER BIOLOGY. 2006;16(4):318-330
The Myc oncoprotein as a therapeutic target for human cancer
Vita M; Henriksson M
Published conference paper: CANCER RESEARCH. 2003;63(8):1743-1747
Molecular characterization of human telomerase reverse transcriptase-immortalized human fibroblasts by gene expression profiling:: Activation of the Epiregulin gene
Lindvall C; Hou M; Komurasaki T; Zheng CY; Henriksson M; Sedivy JM; Björkholm M; Teh BT; Nordenskjöld M; Xu DW
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 1997;224:123-130
Regulation of cell growth by the Myc-Max-Mad network: Role of Mad proteins and YY1
Austen M; Cerni C; Henriksson M; Hilfenhaus S; LuscherFirzlaff JM; Menkel A; Seelos C; Sommer A; Luscher B
Review: MECHANISMS AND THERAPY OF LIVER CANCER. 1996;68:109-182
Proteins of the Myc network: Essential regulators of cell growth and differentiation
Henriksson M; Luscher B
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Professor, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2010-

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