Marc Guitart-Masip

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Forskningsbeskrivning

Jag kombinerar beteendemetoder, beräkningsmodellering, farmakologiska
manipuleringar och bildteknik som fMRI, PET och MEG. Mina forskningsintresse
består numera av: att förstå den roll som neuromodulatorer dopamin har i
motivationsprocessen och beslutsfattande; att förstå sambandet mellan
försämringen av det dopaminerga systemet och kognitiv försämring vid
normalt åldrandet; att förstå hippocampus roll vid alstring av adaptiva
svar i samband med ångest eller nyheter. Dessutom planerar jag en ny studie
för att utöka vår förståelse av kopplingen mellan kognitiva funktioner
som ligger bakom beslutsfattande och depressionsrisk.

Artiklar

Journal article: COMMUNICATIONS PSYCHOLOGY. 2025;3(1):82
A task-invariant prior explains trial-by-trial active avoidance behaviour across gain and loss tasks.
Granwald T; Dayan P; Lengyel M; Guitart-Masip M
Article: DIABETES CARE. 2024;47(10):1794-1802
Diabetes, Prediabetes, and Brain Aging: The Role of Healthy Lifestyle
Dove A; Wang J; Huang H; Dunk MM; Sakakibara S; Guitart-Masip M; Papenberg G; Xu W
Article: EUROPEAN PSYCHIATRY. 2024;67(1):e45
Influence of cognitive reserve on risk of depression and subsequent dementia: A large community-based longitudinal study
Yang W; Wang J; Dove A; Yang Y; Qi X; Guitart-Masip M; Papenberg G; Xu W
Article: NATURE COMMUNICATIONS. 2024;15(1):59
Dopamine release in human associative striatum during reversal learning
Grill F; Guitart-Masip M; Johansson J; Stiernman L; Axelsson J; Nyberg L; Rieckmann A
Article: SCIENTIFIC REPORTS. 2023;13(1):18451
Anxiety associated with perceived uncontrollable stress enhances expectations of environmental volatility and impairs reward learning
Guitart-Masip M; Walsh A; Dayan P; Olsson A
Article: CELL REPORTS. 2023;42(9):113107
Biphasic patterns of age-related differences in dopamine D1 receptors across the adult lifespan
Johansson J; Nordin K; Pedersen R; Karalija N; Papenberg G; Andersson M; Korkki SM; Riklund K; Guitart-Masip M; Rieckmann A; Backman L; Nyberg L; Salami A
Article: CEREBRAL CORTEX. 2023;33(5):1669-1678
Investigating associations of delay discounting with brain structure, working memory, and episodic memory
Garzon B; Kurth-Nelson Z; Backman L; Nyberg L; Guitart-Masip M
Article: NEUROBIOLOGY OF AGING. 2022;118:34-43
Dopamine and reward-related vigor in younger and older adults
Hird EJ; Beierholm U; De Boer L; Axelsson J; Backman L; Guitart-Masip M
Article: FRONTIERS IN PSYCHOLOGY. 2022;13:786778
Enhanced Instructed Fear Learning in Delusion-Proneness
Louzolo A; Almeida R; Guitart-Masip M; Bjornsdotter M; Lebedev A; Ingvar M; Olsson A; Petrovic P
Article: JOURNAL OF NEURAL TRANSMISSION. 2021;128(11):1705-1720
Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function
Richter A; de Boer L; Guitart-Masip M; Behnisch G; Seidenbecher CI; Schott BH
Article: NEURON. 2021;109(12):2025-2040.e7
Decision-making ability, psychopathology, and brain connectivity
Moutoussis M; Garzon B; Neufeld S; Bach DR; Rigoli F; Goodyer I; Bullmore E; Guitart-Masip M; Dolan RJ
Article: BRAIN STRUCTURE & FUNCTION. 2021;226(3):743-758
Role of dopamine and gray matter density in aging effects and individual differences of functional connectomes
Garzon B; Lovden M; de Boer L; Axelsson J; Riklund K; Backman L; Nyberg L; Guitart-Masip M
Article: SCIENTIFIC REPORTS. 2021;11(1):3416
Overcoming Pavlovian bias in semantic space
Ereira S; Pujol M; Guitart-Masip M; Dolan RJ; Kurth-Nelson Z
Article: PLOS COMPUTATIONAL BIOLOGY. 2021;17(2):e1008553
Neural signatures of arbitration between Pavlovian and instrumental action selection
Gershman SJ; Guitart-Masip M; Cavanagh JF
Article: NEUROBIOLOGY OF AGING. 2020;96:49-57
Learning in anticipation of reward and punishment: perspectives across the human lifespan
Betts MJ; Richter A; de Boer L; Tegelbeckers J; Perosa V; Baumann V; Chowdhury R; Dolan RJ; Seidenbecher C; Schott BH; Duezel E; Guitart-Masip M; Krauel K
Article: CEREBRAL CORTEX. 2020;30(10):5270-5280
Corticostriatal White Matter Integrity and Dopamine D1 Receptor Availability Predict Age Differences in Prefrontal Value Signaling during Reward Learning
de Boer L; Garzon B; Axelsson J; Riklund K; Nyberg L; Backman L; Guitart-Masip M
Article: CEREBRAL CORTEX. 2020;30(6):3573-3589
Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models
Adams RA; Moutoussis M; Nour MM; Dahoun T; Lewis D; Illingworth B; Veronese M; Mathys C; de Boer L; Guitart-Masip M; Friston KJ; Howes OD; Roiser JP
Article: CEREBRAL CORTEX. 2020;30(5):3340-3351
The Role of the Striatum in Learning to Orthogonalize CD Action and Valence: A Combined PET and 7 T MRI Aging Study
Perosa V; de Boer L; Ziegler G; Apostolova I; Buchert R; Metzger C; Amthauer H; Guitart-Masip M; Duezel E; Betts MJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(1):261-270
Dorsal striatal dopamine D1 receptor availability predicts an instrumental bias in action learning
de Boer L; Axelsson J; Chowdhury R; Riklund K; Dolan RJ; Nyberg L; Backman L; Guitart-Masip M
Article: CEREBRAL CORTEX. 2018;28(11):3894-3907
Latent-Profile Analysis Reveals Behavioral and Brain Correlates of Dopamine-Cognition Associations
Lovden M; Karalija N; Andersson M; Wahlin A; Axelsson J; Kohncke Y; Jonasson LS; Rieckman A; Papenberg G; Garrett DD; Guitart-Masip M; Salami A; Riklund K; Backman L; Nyberg L; Lindenberger U
Article: PLOS ONE. 2018;13(8):e0201451
Neural activity and fundamental learning, motivated by monetary loss and reward, are intact in mild to moderate major depressive disorder
Moutoussis M; Rutledge RB; Prabhu G; Hrynkiewicz L; Lam J; Ousdal O-T; Guitart-Masip M; Fonagy P; Dolan RJ
Article: NEUROSCIENCE LETTERS. 2018;673:92-98
Distinct phenotypes of spontaneous activity and induction of amphetamine sensitization in inbred Roman high- and low-avoidance rats: Vulnerability and protection
Gimenez-Llort L; Guitart-Masip M; Tobena A; Fernandez-Teruel A; Johansson B
Article: ELIFE. 2017;6:e26424
Attenuation of dopamine-modulated prefrontal value signals underlies probabilistic reward learning deficits in old age
de Boer L; Axelsson J; Riklund K; Nyberg L; Dayan P; Backman L; Guitart-Masip M
Article: CEREBRAL CORTEX. 2017;27(1):201-215
Parsing the Role of the Hippocampus in Approach-Avoidance Conflict
Loh E; Kurth-Nelson Z; Berron D; Dayan P; Duzel E; Dolan R; Guitart-Masip M
Article: CEREBRAL CORTEX. 2016;26(5):2074-2083
BOLD Variability is Related to Dopaminergic Neurotransmission and Cognitive Aging
Guitart-Masip M; Salami A; Garrett D; Rieckmann A; Lindenberger U; Backman L
Article: CEREBRAL CORTEX. 2015;25(12):4908-4917
Basal Ganglia Activity Mirrors a Benefit of Action and Reward on Long-Lasting Event Memory
Koster R; Guitart-Masip M; Dolan RJ; Duezel E
Article: CEREBRAL CORTEX. 2015;25(10):3629-3639
Dopamine, Salience, and Response Set Shifting in Prefrontal Cortex
Shiner T; Symmonds M; Guitart-Masip M; Fleming SM; Friston KJ; Dolan RJ
Article: PLOS COMPUTATIONAL BIOLOGY. 2015;11(9):e1004463
Model-Based Reasoning in Humans Becomes Automatic with Training
Economides M; Kurth-Nelson Z; Luebbert A; Guitart-Masip M; Dolan RJ
Article: JOURNAL OF NEUROLOGY. 2015;262(6):1541-1547
Deep brain stimulation of the subthalamic nucleus modulates reward processing and action selection in Parkinson patients
Wagenbreth C; Zaehle T; Galazky I; Voges J; Guitart-Masip M; Heinze H-J; Duezel E
Article: NEUROIMAGE. 2015;109:206-216
Arbitration between controlled and impulsive choices
Economides M; Guitart-Masip M; Kurth-Nelson Z; Dolan RJ
Article: CEREBRAL CORTEX. 2014;24(5):1351-1360
Pharmacological Dissociation of Novelty Responses in the Human Brain
Bunzeck N; Guitart-Masip M; Dolan RJ; Duzel E
Article: CURRENT BIOLOGY. 2014;24(5):541-547
Human Hippocampus Arbitrates Approach-Avoidance Conflict
Bach DR; Guitart-Masip M; Packard PA; Miro J; Falip M; Fuentemilla L; Dolan RJ
Article: PSYCHOPHARMACOLOGY. 2014;231(5):955-966
Differential, but not opponent, effects of L-DOPA and citalopram on action learning with reward and punishment
Guitart-Masip M; Economides M; Huys QJM; Frank MJ; Chowdhury R; Duzel E; Dayan P; Dolan RJ
Article: JOURNAL OF NEUROSCIENCE. 2014;34(9):3340-3349
Anterior Cingulate Cortex Instigates Adaptive Switches in Choice by Integrating Immediate and Delayed Components of Value in Ventromedial Prefrontal Cortex
Economides M; Guitart-Masip M; Kurth-Nelson Z; Dolan RJ
Article: FRONTIERS IN SYSTEMS NEUROSCIENCE. 2014;8:140
Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression
Richter A; Guitart-Masip M; Barman A; Libeau C; Behnisch G; Czemey S; Schanze D; Assmann A; Klein M; Duzel E; Zenker M; Seidenbecher CL; Schott BH
Article: JOURNAL OF NEUROSCIENCE. 2013;33(46):18087-18097
Preparing for Selective Inhibition within Frontostriatal Loops
Smittenaar P; Guitart-Masip M; Lutti A; Dolan RJ
Article: NEUROBIOLOGY OF AGING. 2013;34(10):2261-2270
Structural integrity of the substantia nigra and subthalamic nucleus predicts flexibility of instrumental learning in older-age individuals
Chowdhury R; Guitart-Masip M; Lambert C; Dolan RJ; Duezel E
Article: NEUROIMAGE. 2013;78:135-144
Electrophysiological correlates of anticipating improbable but desired events
Fuentemilla L; Cucurell D; Marco-Pallares J; Guitart-Masip M; Moris J; Rodriguez-Fornells A
Article: NEUROPSYCHOPHARMACOLOGY. 2013;38(8):1495-1503
Dopamine Modulates Reward-Related Vigor
Beierholm U; Guitart-Masip M; Economides M; Chowdhury R; Duezel E; Dolan R; Dayan P
Article: JOURNAL OF NEUROSCIENCE. 2013;33(19):8541-8548
Frontal Theta Overrides Pavlovian Learning Biases
Cavanagh JF; Eisenberg I; Guitart-Masip M; Huys Q; Frank MJ
Article: NATURE NEUROSCIENCE. 2013;16(5):648-653
Dopamine restores reward prediction errors in old age
Chowdhury R; Guitart-Masip M; Lambert C; Dayan P; Huys Q; Duezel E; Dolan RJ
Article: JOURNAL OF NEUROSCIENCE. 2013;33(14):6160-6169
Effort and Valuation in the Brain: The Effects of Anticipation and Execution
Kurniawan IT; Guitart-Masip M; Dayan P; Dolan RJ
Article: JOURNAL OF NEUROSCIENCE. 2013;33(2):442-451
Synchronization of Medial Temporal Lobe and Prefrontal Rhythms in Human Decision Making
Guitart-Masip M; Barnes GR; Horner A; Bauer M; Dolan RJ; Duzel E
Article: FRONTIERS IN NEUROSCIENCE. 2013;7:228
Manipulating the contribution of approach-avoidance to the perturbation of economic choice by valence
Wright ND; Morris LS; Guitart-Masip M; Dolan RJ
Article: JOURNAL OF NEUROSCIENCE. 2012;32(41):14193-14204
Dopamine Modulates Episodic Memory Persistence in Old Age
Chowdhury R; Guitart-Masip M; Bunzeck N; Dolan RJ; Duezel E
Article: SCIENTIFIC REPORTS. 2012;2:593
Human responses to unfairness with primary rewards and their biological limits
Wright ND; Hodgson K; Fleming SM; Symmonds M; Guitart-Masip M; Dolan RJ
Article: CURRENT BIOLOGY. 2012;22(16):1477-1481
How Dopamine Enhances an Optimism Bias in Humans
Sharot T; Guitart-Masip M; Korn CW; Chowdhury R; Dolan RJ
Article: NEUROIMAGE. 2012;62(1):154-166
Go and no-go learning in reward and punishment: Interactions between affect and effect
Guitart-Masip M; Nuys QJM; Fuentemilla L; Dayan P; Duzel E; Dolan RJ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(19):7511-7516
Action controls dopaminergic enhancement of reward representations
Guitart-Masip M; Chowdhury R; Sharot T; Dayan P; Duzel E; Dolan RJ
Article: JOURNAL OF COGNITIVE NEUROSCIENCE. 2011;23(12):3933-3938
Vigor in the Face of Fluctuating Rates of Reward: An Experimental Examination
Guitart-Masip M; Beierholm UR; Dolan R; Duzel E; Dayan P
Article: JOURNAL OF NEUROSCIENCE. 2011;31(36):12816-12822
Contextual Novelty Modulates the Neural Dynamics of Reward Anticipation
Bunzeck N; Guitart-Masip M; Dolan RJ; Duezel E
Article: JOURNAL OF NEUROSCIENCE. 2011;31(21):7867-7875
Action Dominates Valence in Anticipatory Representations in the Human Striatum and Dopaminergic Midbrain
Guitart-Masip M; Fuentemilla L; Bach DR; Huys QJM; Dayan P; Dolan RJ; Duzel E
Article: PHYSIOLOGY & BEHAVIOR. 2011;103(2):148-156
Two-way avoidance acquisition is negatively related to conditioned freezing and positively associated with startle reactions: A dissection of anxiety and fear in genetically heterogeneous rats
Vicens-Costa E; Martinez-Membrives E; Lopez-Aumatell R; Guitart-Masip M; Canete T; Blazquez G; Tobena A; Fernandez-Teruel A
Article: FRONTIERS IN NEUROSCIENCE. 2011;5:81
Dopamine and effort-based decision making
Kurniawan IT; Guitart-Masip M; Dolan RJ
Article: NEUROIMAGE. 2010;53(1):206-214
Conditioned associations and economic decision biases
Guitart-Masip M; Talmi D; Dolan R
Article: JOURNAL OF NEUROSCIENCE. 2010;30(5):1721-1726
Contextual Novelty Changes Reward Representations in the Striatum
Guitart-Masip M; Bunzeck N; Stephan KE; Dolan RJ; Duezel E
Article: BEHAVIOURAL BRAIN RESEARCH. 2009;202(1):92-101
Unlearned anxiety predicts learned fear: A comparison among heterogeneous rats and the Roman rat strains
Lopez-Aumatell R; Vicens-Costa E; Guitart-Masip M; Martinez-Membrives E; Valdar W; Johannesson M; Canete T; Blazquez G; Driscoll P; Flint J; Tobena A; Fernandez-Teruel A
Article: GENOME RESEARCH. 2009;19(1):150-158
A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock
Johannesson M; Lopez-Aumatell R; Stridh P; Diez M; Tuncel J; Blazquez G; Martinez-Membrives E; Canete T; Vicens-Costa E; Graham D; Copley RR; Hernandez-Pliego P; Beyeen AD; Ockinger J; Fernandez-Santamaria C; Gulko PS; Brenner M; Tobena A; Guitart-Masip M; Gimenez-Llort L; Dominiczak A; Holmdahl R; Gauguier D; Olsson T; Mott R; Valdar W; Redei EE; Fernandez-Teruel A; Flint J
Article: NEUROCHEMICAL RESEARCH. 2008;33(10):2062-2069
Effects of naltrexone and acamprosate on alcohol-induced NGFI-A expression in mouse brain
Lindholm J; Guitart-Masip M; Hassankhali H; Landgren S; Nicoleau C; Gimenez-Llort L; Terenius L; Oegren SO; Johansson B
Article: BEHAVIOURAL BRAIN RESEARCH. 2008;188(1):41-55
Fearfulness in a large N/Nih genetically heterogeneous rat stock:: Differential profiles of timidity and defensive flight in males and females
Lopez-Aumatell R; Guitart-Masip M; Vicens-Costa E; Gimenez-Llort L; Valdar W; Johannesson M; Flint J; Tobena A; Femandez-Teruel A
Article: NEUROSCIENCE. 2008;151(1):195-208
Regional adaptations in PSD-95, NGFI-A and secretogranin gene transcripts related to vulnerability to behavioral sensitization to amphetamine in the Roman rat strains
Guitart-Masip M; Johansson B; Canete T; Fernandez-Teruel A; Tobena A; Terenius L; Gimenez-Llort L
Article: PSYCHOPHARMACOLOGY. 2008;196(1):39-49
Divergent effect of the selective D₃ receptor agonist pd-128,907 on locomotor activity in Roman high- and low-avoidance rats:: relationship to NGFI-A gene expression in the Calleja islands
Guitart-Masip M; Johansson B; Fernandez-Teruel A; Tobena A; Gimenez-Llort L
Article: NEUROSCIENCE. 2006;142(4):1231-1243
Divergent anatomical pattern of D₁ and D₃ binding and dopamine- and cyclic AMP-regulated phosphoprotein of 32 kDa mRNA expression in the Roman rat strains:: Implications for drug addiction
Guitart-Masip M; Johansson B; Fernandez-Teruel A; Canete T; Tobena A; Terenius L; Gimenez-Llort L
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2006;23(2):531-540
Reduced ethanol response in the alcohol-preferring RHA rats and neuropeptide mRNAs in relevant structures
Guitart-Masip M; Giménez-Llort L; Fernández-Teruel A; Cañete T; Tobeña A; Ögren SO; Terenius L; Johansson B
Article: PHYSIOLOGY & BEHAVIOR. 2005;86(4):458-466
Two distinctive apomorphine-induced phenotypes in the Roman high- and low-avoidance rats
Giménez-Llort L; Cañete T; Guitart-Masip M; Fernández-Teruel A; Tobeña A
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Alla övriga publikationer

Editorial comment: BEHAVIORAL AND BRAIN SCIENCES. 2024;47:e77
Dynamic diversity is the answer to proxy failure
Kurth-Nelson Z; Sullivan S; Leibo JZ; Guitart-Masip M
Review: EUROPEAN JOURNAL OF AGEING. 2022;19(4):945-952
A link between age, affect, and predictions?
Trapp S; Guitart-Masip M; Schroeger E
Corrigendum: JOURNAL OF NEURAL TRANSMISSION. 2022;129(1):117-122
Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function (July, 10.1007/s00702-021-02382-4, 2021)
Richter A; de Boer L; Guitart-Masip M; Behnisch G; Seidenbecher CI; Schott BH
Corrigendum: CEREBRAL CORTEX. 2020;30(6):3857
The Role of the Striatum in Learning to Orthogonalize Action and Valence: A Combined PET and 7 T MRI Aging Study (vol 30, pg 3340, 2020)
Perosa V; de Boer L; Ziegler G; Apostolova I; Buchert R; Metzger C; Amthauer H; Guitart-Masip M; Duezel E; Betts MJ
Corrigendum: FRONTIERS IN SYSTEMS NEUROSCIENCE. 2015;9:36
Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression (vol 8, pg 140, 2014)
Richter A; Guitart-Masip M; Barman A; Libeau C; Behnisch G; Czerney S; Schanze D; Assmann A; Klein M; Duezel E; Zenker M; Seidenbecher C; Schott BH
Corrigendum: NATURE NEUROSCIENCE. 2014;17(12):1840
Dopamine restores reward prediction errors in old age (vol 16, pg 648, 2013)
Chowdhury R; Guitart-Masip M; Lambert C; Dayan P; Huys Q; Duezel E; Dolan RJ
Corrigendum: CURRENT BIOLOGY. 2014;24(12):1435
Human Hippocampus Arbitrates Approach-Avoidance Conflict.
Bach DR; Guitart-Masip M; Packard PA; Miró J; Falip M; Fuentemilla L; Dolan RJ
Review: TRENDS IN COGNITIVE SCIENCES. 2014;18(4):194-202
Action versus valence in decision making
Guitart-Masip M; Duzel E; Dolan R; Dayan P
Editorial comment: NEURON. 2013;79(1):9-11
Not So Uncertain at Last: Locus Coeruleus and Decision Making
Duzel E; Guitart-Masip M
Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2010;34(5):660-669
NOvelty-related Motivation of Anticipation and exploration by Dopamine (NOMAD): Implications for healthy aging
Duezel E; Bunzeck N; Guitart-Masip M; Duezel S
Review: PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY. 2009;33(8):1537-1545
Neural correlates of impaired emotional discrimination in borderline personality disorder: An fMRI study
Guitart-Masip M; Carlos Pascual J; Carmona S; Hoekzema E; Berge D; Perez V; Soler J; Carles Soliva J; Rovira M; Bulbena A; Vilarroya O
Review: TRENDS IN NEUROSCIENCES. 2009;32(6):321-328
Functional imaging of the human dopaminergic midbrain
Duezel E; Bunzeck N; Guitart-Masip M; Wittmann B; Schott BH; Tobler PN

Anställningar

Senior Forskare, Klinisk neurovetenskap, Karolinska Institutet, 2025-
Senior Forskare, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2022-2025

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