Malene Lindholm

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: BMC BIOLOGY. 2024;22(1):147

DNA methylation of exercise-responsive genes differs between trained and untrained men

Geiger C; Needhamsen M; Emanuelsson EB; Norrbom J; Steindorf K; Sundberg CJ; Reitzner SM; Lindholm ME
Journal article: CELL GENOMICS. 2024;4(6):100421

Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures

Nair VD; Pincas H; Smith GR; Zaslavsky E; Ge Y; Amper MAS; Vasoya M; Chikina M; Sun Y; Raja AN; Mao W; Gay NR; Esser KA; Smith KS; Zhao B; Wiel L; Singh A; Lindholm ME; Amar D; Montgomery S; Snyder MP; Walsh MJ; Sealfon SC
Journal article: CELL METABOLISM. 2024;36(6):1411-1429.e10

The mitochondrial multi-omic response to exercise training across rat tissues

Amar D; Gay NR; Jimenez-Morales D; Beltran PMJ; Ramaker ME; Raja AN; Zhao B; Sun Y; Marwaha S; Gaul DA; Hershman SG; Ferrasse A; Xia A; Lanza I; Fernandez FM; Montgomery SB; Hevener AL; Ashley EA; Walsh MJ; Sparks LM; Burant CF; Rector RS; Thyfault J; Wheeler MT; Goodpaster BH; Coen PM; Schenk S; Bodine SC; Lindholm ME
Journal article: NATURE. 2024;629(8010):174-183

Temporal dynamics of the multi-omic response to endurance exercise training
Journal article: NATURE METABOLISM. 2024;6(5):963-979

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue

Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock KL; Amar D; Caputo T; Gay NR; Gaul DA; Hirshman MF; Jimenez-Morales D; Lindholm ME; Muehlbauer MJ; Vamvini M; Bergman BC; Fernandez FM; Goodyear LJ; Hevener AL; Ortlund EA; Sparks LM; Xia A; Adkins JN; Bodine SC; Newgard CB; Schenk S; Adkins JN; Armenteros JJA; Amar D; Amper MAS; Ashley E; Asokan AK; Avila-Pacheco J; Bae D; Bamman MM; Bararpour N; Barnes J; Bergman BC; Bodine SC; Buford TW; Burant CF; Caputo T; Carbone NP; Carr SA; Chambers TL; Chavez C; Chiu R; Clish CB; Cutter GR; Dasari S; Dennis C; Evans CR; Fernandez FM; Gagne N; Gaul DA; Gay NR; Ge Y; Goodpaster BH; Goodyear LJ; Gritsenko MA; Hansen JR; Hennig KM; Hevener AL; Hirshman MF; Hou Z; Huffman KM; Hung C-J; Hutchinson-Bunch C; Ilkayeva O; Ivanova AA; Beltran PMJ; Jimenez-Morales D; Jin CA; Kachman MT; Keshishian H; Kraus WE; Lanza I; Lester B; Li JZ; Lindholm ME; Lira AK; Liu X; Maner-Smith KM; Many GM; May S; Monroe MR; Montgomery S; Moore RJ; Moore SG; Muehlbauer MJ; Nachun D; Nair KS; Nair V; Raja AN; Nestor MD; Newgard CB; Nigro P; Nudelman G; Ortlund EA; Petyuk VA; Piehowski PD; Pincas H; Qian W-J; Raskind A; Rasmussen BB; Rooney JL; Rushing S; Sagendorf TJ; Samdarshi M; Sanford JA; Schenk S; Sealfon SC; Smith KS; Smith GR; Snyder M; Sparks LM; Stowe CL; Talton JW; Teng C; Thalacker-Mercer A; Tracy R; Trappe TA; Vamvini M; Vasoya M; Vetr NG; Volpi E; Walkup MP; Walsh MJ; Wheeler MT; Whytock KL; Wu S; Xia A; Zaslavsky E; Zebarjadi N; Zhang T; Zhao B; Zhen J
Article: ISCIENCE. 2024;27(1):108638

Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training

Emanuelsson EB; Arif M; Reitzner SM; Perez S; Lindholm ME; Mardinoglu A; Daub C; Sundberg CJ; Chapman MA
Article: AGING CELL. 2024;23(1):e13859

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Voisin S; Seale K; Jacques M; Landen S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Thompson J-LM; Doering TM; Lindholm ME; Walsh C; Davison G; Irwin R; McBride C; Hansson O; Asplund O; Heikkinen AE; Piirila P; Pietilainen KH; Ollikainen M; Blocquiaux S; Thomis M; Dawn CK; Sharples AP; Eynon N
Article: ANTIOXIDANTS. 2023;12(12):2043

Comparing the Blood Response to Hyperbaric Oxygen with High-Intensity Interval Training-A Crossover Study in Healthy Volunteers

Kjellberg A; Lindholm ME; Zheng X; Liwenborg L; Rodriguez-Wallberg KA; Catrina S-B; Lindholm P
Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2021;14(6):e003419

Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms

Lindholm ME; Jimenez-Morales D; Zhu H; Seo K; Amar D; Zhao C; Raja A; Madhvani R; Abramowitz S; Espenel C; Sutton S; Caleshu C; Berry GJ; Motonaga KS; Dunn K; Platt J; Ashley EA; Wheeler MT
Article: NATURE COMMUNICATIONS. 2021;12(1):3471

Time trajectories in the transcriptomic response to exercise - a meta-analysis

Amar D; Lindholm ME; Norrbom J; Wheeler MT; Rivas MA; Ashley EA
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(8):1679-1690

Exercise Induces Different Molecular Responses in Trained and Untrained Human Muscle

Moberg M; Lindholm ME; Reitzner SM; Ekblom B; Sundberg C-J; Psilander N
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2020;11(4):887-898

An epigenetic clock for human skeletal muscle

Voisin S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Doering TM; Thompson J-LM; Benedict C; Cedernaes J; Lindholm ME; Craig JM; Rowlands DS; Sharples AP; Horvath S; Eynon N
Article: CELL REPORTS. 2020;31(12):107808

Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women

Chapman MA; Arif M; Emanuelsson EB; Reitzner SM; Lindholm ME; Mardinoglu A; Sundberg CJ
Article: CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS. 2018;10:148-153

Metabolic and functional changes in transgender individuals following cross-sex hormone treatment: Design and methods of the GEnder Dysphoria Treatment in Sweden (GETS) study

Wiik A; Andersson DP; Brismar TB; Chanpen S; Dhejne C; Ekstrom TJ; Flanagan JN; Holmberg M; Kere J; Lilja M; Lindholm ME; Lundberg TR; Maret E; Melin M; Olsson SM; Rullman E; Wahlen K; Arver S; Gustafsson T
Article: NATURE COMMUNICATIONS. 2018;9(1):1612

Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study

DeBoever C; Tanigawa Y; Lindholm ME; McInnes G; Lavertu A; Ingelsson E; Chang C; Ashley EA; Bustamante CD; Daly MJ; Rivas MA
Article: PLOS GENETICS. 2016;12(9):e1006294

The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts

Lindholm ME; Giacomello S; Solnestam B; Fischer H; Huss M; Kjellqvist S; Sundberg CJ
Article: EXPERIMENTAL PHYSIOLOGY. 2016;101(1):28-32

Skeletal muscle hypoxia-inducible factor-1 and exercise

Lindholm ME; Rundqvist H
Article: BMC GENOMICS. 2015;16(1):475

The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling

Lindskog C; Linne J; Fagerberg L; Hallstrom BM; Sundberg CJ; Lindholm M; Huss M; Kampf C; Choi H; Liem DA; Ping P; Varemo L; Mardinoglu A; Nielsen J; Larsson E; Ponten F; Uhlen M
Article: EPIGENETICS. 2014;9(12):1557-1569

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training

Lindholm ME; Marabita F; Gomez-Cabrero D; Rundqvist H; Ekstrom TJ; Tegner J; Sundberg CJ
Article: FASEB JOURNAL. 2014;28(10):4571-4581

The human skeletal muscle transcriptome: sex differences, alternative splicing, and tissue homogeneity assessed with RNA sequencing

Lindholm ME; Huss M; Solnestam BW; Kjellqvist S; Lundeberg J; Sundberg CJ
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2014;307(3):r248-r255

Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism

Lindholm ME; Fischer H; Poellinger L; Johnson RS; Gustafsson T; Sundberg CJ; Rundqvist H
Article: EPIGENETICS. 2013;8(3):333-346

An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform

Marabita F; Almgren M; Lindholm ME; Ruhrmann S; Fagerstrom-Billai F; Jagodic M; Sundberg CJ; Ekstrom TJ; Teschendorff AE; Tegner J; Gomez-Cabrero D
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Preprint: BIORXIV. 2023;BIORXIV

Multi-omic identification of key transcriptional regulatory programs during endurance exercise training.

Smith GR; Zhao B; Lindholm ME; Raja A; Viggars M; Pincas H; Gay NR; Sun Y; Ge Y; Nair VD; Sanford JA; Amper MAS; Vasoya M; Smith KS; Montgomery S; Zaslavsky E; Bodine SC; Esser KA; Walsh MJ; Snyder MP; MoTrPAC Study Group
Preprint: BIORXIV. 2023;BIORXIV

Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.

Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock K; Amar D; Caputo T; Gay NR; Gaul DA; Hirshman M; Jimenez-Morales D; Lindholm ME; Muehlbauer MJ; Vamvini M; Bergman B; Fern Ndez FM; Goodyear LJ; Ortlund EA; Sparks LM; Xia A; Adkins JN; Bodine SC; Newgard CB; Schenk S; MoTrPAC Study Group
Preprint: BIORXIV. 2023;BIORXIV

The mitochondrial multi-omic response to exercise training across tissues.

Amar D; Gay NR; Jimenez-Morales D; Beltran PMJ; Ramaker ME; Raja AN; Zhao B; Sun Y; Marwaha S; Gaul D; Hershman SG; Xia A; Lanza I; Fernandez FM; Montgomery SB; Hevener AL; Ashley EA; Walsh MJ; Sparks LM; Burant CF; Rector RS; Thyfault J; Wheeler MT; Goodpaster BH; Coen PM; Schenk S; Bodine SC; Lindholm ME; MoTrPAC Study Group
Preprint: BIORXIV. 2022

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Voisin S; Seale K; Jacques M; Landen S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Thompson J-LM; Doering TM; Lindholm ME; Walsh C; Davison G; Irwin R; McBride C; Hansson O; Asplund O; Heikkinen AE; Piirilä P; Pietiläinen KH; Ollikainen M; Blocquiaux S; Thomis M; Coletta DK; Sharples AP; Eynon N
Preprint: BIORXIV. 2022

Temporal dynamics of the multi-omic response to endurance exercise training across tissues

Group MS; Amar D; Gay NR; Beltran PMJ; Adkins JN; Armenteros JJA; Ashley E; Avila-Pacheco J; Bae D; Bararpour N; Burant C; Clish C; Cutter G; Dasari S; Dennis C; Evans CR; Fernández FM; Gaul D; Ge Y; Gerszten R; Goodyear LJ; Hou Z; Ilkayeva O; Ivanova AA; Jimenez-Morales D; Kachman MT; Keshishian H; Kraus WE; Lanza IR; Li J; Lindholm ME; Lira AC; Many GM; Marwaha S; Miller ME; Muehlbauer MJ; Nair KS; Nair VD; Raja AN; Newgard C; Ortlund EA; Piehowski PD; Presby DM; Qian W-J; Rooney JL; Sanford JA; Savage E; Sealfon SC; Smith GR; Smith KS; Steep A; Stowe CL; Sun Y; Tracy R; Vetr NG; Walsh MJ; Wu S; Zhang T; Zhao B; Zhen J; Albertson BG; Amper MAS; Balci AT; Bamman M; Barton ER; Bergman B; Bessesen D; Booth F; Bouverat B; Buford TW; Caputo T; Chambers TL; Chavez C; Chikina M; Chiu R; Cicha M; Coen PM; Cooper D; Cornell E; Dalton KP; De Sousa LO; Farrar R; Gadde K; Gagne N; Goodpaster BH; Gritsenko MA; Guevara K; Haddad F; Hansen JR; Harris M; Hastie T; Hennig KM; Hershman SG; Hevener A; Hirshman MF; Hsu F-C; Huffman KM; Hung C-J; Hutchinson-Bunch C; Jackson BE; Jankowski C; Jin CA; Johannsen NM; Ke BG; Kohrt WM; Kramer KS; Leeuwenburgh C; Lessard SJ; Lester B; Liu X; Lu C-J; Makarewicz NS; Maner-Smith KM; Mani; Marjanovic N; Marshall A; May S; Melanson E; Monroe ME; Moore RJ; Moore S; Moreau KL; Mundorff CC; Musi N; Nachun D; Nestor MD; Newton RL; Nicklas B; Nigro P; Nudelman G; Pahor M; Pearce C; Petyuk VA; Pincas H; Powers S; Radom-Aizik S; Ramachandran K; Ramaker ME; Ramos I; Rankinen T; Raskind A; Rasmussen BB; Ravussin E; Rector RS; Rejeski WJ; Richards C; Rirak S; Robbins JM; Rubenstein AB; Ruf-Zamojski F; Rushing S; Sagendorf TJ; Samdarshi M; Schauer IE; Schwartz R; Seenarine N; Soni T; Sparks LM; Teng C; Thalacker-Mercer A; Thyfault J; Tibshirani R; Trappe S; Trappe TA; Uppal K; Vangeti S; Vasoya M; Volpi E; Vornholt A; Walkup MP; Williams J; Xia A; Yan Z; Yu X; Zang C; Zaslavsky E; Zebarjadi N; Bodine SC; Carr S; Esser K; Montgomery SB; Schenk S; Snyder MP; Wheeler MT
Conference publication: ACTA PHYSIOLOGICA. 2022;236:57

Do muscles have memory?Molecular effects of training, detraining and retraining

Lindholm ME
Preprint: BIORXIV. 2020

Mono- and bi-allelic protein truncating variants in alpha-actinin 2 cause cardiomyopathy through distinct mechanisms

Lindholm M; Jimenez-Morales D; Zhu H; Seo K; Amar D; Zhao C; Raja A; Madhvani R; Espenel C; Sutton S; Caleshu C; Berry G; Motonaga K; Dunn K; Platt J; Ashley E; Wheeler M
Conference publication: CIRCULATION. 2020;142(Suppl_3)

Abstract 14355: Mono- and Biallelic Structural Variants in Alpha-actinin 2 Cause Contractile Dysfunction and Cardiomyopathy in Humans

Lindholm ME; Zhu H; Seo K; Jimenez-Morales D; Zhao C; Ashley EA; Wheeler MT
Review: CELL. 2020;181(7):1464-1474

Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise

Sanford JA; Nogiec CD; Lindholm ME; Adkins JN; Amar D; Dasari S; Drugan JK; Fernandez FM; Radom-Aizik S; Schenk S; Snyder MP; Tracy RP; Vanderboom P; Trappe S; Walsh MJ
Conference publication: CIRCULATION. 2020;142

Mono- and Biallelic Structural Variants in Alpha-actinin 2 Cause Contractile Dysfunction and Cardiomyopathy in Humans

Lindholm ME; Zhu H; Seo K; Jimenez-Morales D; Zhao C; Ashley EA; Wheeler MT
Preprint: BIORXIV. 2019

Differential response trajectories to acute exercise in blood and muscle

Amar D; Lindholm M; Norrbom J; Wheeler M; Rivas M; Ashley E
Preprint: BIORXIV. 2019

An epigenetic clock for human skeletal muscle

Voisin S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Doering TM; Thompson JM; Benedict C; Cedernaes J; Lindholm ME; Craig JM; Rowlands DS; Sharples AP; Horvath S; Eynon N
Conference publication: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2019;73(9):1027

NOVEL ALPHA-ACTININ 2 MUTATIONS ARE ASSOCIATED WITH CARDIOMYOPATHY AND HYPERTROPHY IN HUMAN CARDIAC TISSUE AND IPSC-DERIVED CARDIOMYOCYTES

Lindholm M; Zhu H; Huang Y; Ashley EA; Wheeler M
Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1310

Structural variants in Alpha-actinin 2 are associated with cardiomyopathy and hypertrophy in human cardiac tissue and iPSC-derived cardiomyocytes

Lindholm ME; Zhu H; Huang Y; Ashley EA; Wheeler M
Preprint: SSRN ELECTRONIC JOURNAL. 2019

Differential Response Trajectories to Acute Exercise in Blood and Muscle

Amar D; Lindholm ME; Norrbom J; Wheeler MT; Rivas M; Ashley EA
Conference publication: FASEB JOURNAL. 2016;30

Endurance Training Alters Expression of Over 3000 Isoforms and 34 Novel Transcripts in Human Skeletal Muscle

Lindholm M; Giacomello S; Solnestam BW; Fischer H; Kjellqvist S; Huss M; Sundberg CJ
Thesis / dissertation: 2015

The search for human skeletal muscle memory : exercise effects on the transcriptome and epigenome

Lindholm, Maléne
Conference publication: ACTA PHYSIOLOGICA. 2014;211:38

The human skeletal muscle transcriptome - sex differences, alternative splicing and tissue homogeneity assessed with RNA sequencing

Lindholm ME; Huss M; Solnestam BW; Kjellqvist S; Lundeberg J; Sundberg CJ
Conference publication: FASEB JOURNAL. 2013;27(S1):1134.1

Endurance training changes the DNA methylation pattern in human skeletal muscle

Lindholm ME; Marabita F; Gomez‐Cabrero D; Fischer H; Tegnér J; Sundberg CJ
Conference publication: FASEB JOURNAL. 2012;26:533.3

Human skeletal muscle histone modifications in response to six weeks of endurance training

Ydfors M; Lindholm M; Sundberg CJ
Conference publication: FASEB JOURNAL. 2012;26:1086.11

Variation of global mRNA expression in biopsies from the same human muscle

Sundberg CJB; Lindholm M; Solnestam BW; Lundberg J; Fischer H
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Forskningsbidrag

Exercise-induced cardiac adaptation in hypertrophic cardiomyopathy

National Heart Lung and Blood Institute

1 July 2022 - 31 December 2024
Genome-scale mechanisms of adaptation in long-term exercise trained humans – skeletal muscle and adipose tissue crosstalk assessed through spatial transcriptomics analysis

Swedish Research Council

1 January 2019 - 31 December 2021

Anställningar

Anknuten till Forskning, Fysiologi och farmakologi, Karolinska Institutet, 2023-2026

Examina och utbildning

Medicine Doktorsexamen, Institutionen för fysiologi och farmakologi, Karolinska Institutet, 2015
Medicine Magisterexamen, Karolinska Institutet, 2009

Artiklar

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Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

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