Malene Lindholm

About me
Publications
Grants
CV
Public outreach and news

About me

I am a translational scientist with a PhD in medical science working at the intersection of cardiometabolic disease, bioinformatics and molecular biology, currently serving as senior research engineer and Director of the Human Molecular Athlete Moonshot at Stanford University.

Research

My research is dedicated to deciphering the specific molecular mechanisms that mediate the health benefits of exercise, a crucial determinant in combating the global health crisis posed by sedentary lifestyles. Recognized as the fourth leading risk factor for mortality worldwide, physical inactivity is a modifiable behavior that, if addressed, has the potential to prevent numerous leading causes of premature mortality, including type II diabetes and cardiovascular diseases. By leveraging cutting-edge exercise interventions and multi-omic techniques alongside advanced cellular
models, my work aims not only to delineate the molecular pathways that confer exercise’s protective effects but also to translate these findings into actionable strategies for the prevention and treatment of cardiometabolic conditions. This integrative approach stands to offer transformative insights into public health policies and therapeutic innovations, towards the goal of precision exercise health.

Articles

Journal article: CIRCULATION RESEARCH. 2025;137(7):1045-1047
Endurance Training Enhances Sex-Specific Cardioprotective Metabolism.
Brochet P; Montalvo S; Lindholm ME; Jimenez-Morales D; Jin CA; Rasmussen BB; Kraus WE; Yan Z; Wheeler MT; Katz DH
Journal article: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2025;:S1043-2760(25)00151-1
Exercise pills for cardiometabolic health cannot mimic the exercise milieu.
Plaza-Florido A; Lindholm ME; Carrera-Bastos P; Santos-Lozano A; Valenzuela PL; Fiuza-Luces C; Radom-Aizik S; Lucia A
Journal article: FRONTIERS IN CARDIOVASCULAR MEDICINE. 2025;12:1546493
Identification of candidate cardiomyopathy modifier genes through genome sequencing and RNA profiling
Lindholm ME; Abramowitz S; Waggott DM; Grove ME; Dewey FE; Pan C; Pavlovic A; Shang C; Huang Y; Bensabath L; Goldfeder RL; Cordero P; Erbilgin A; Priest JR; Chaib H; Puckelwartz MJ; Day SM; Mcnally EM; Cappola T; Dorn GW; Ashley EA; Wheeler MT
Journal article: CIRCULATION RESEARCH. 2025;136(11):1407-1432
Skeletal Muscle as a Mediator of Interorgan Crosstalk During Exercise: Implications for Aging and Obesity
Shero JA; Lindholm ME; Sandri M; Stanford KI
Article: BMC MEDICAL ETHICS. 2025;26(1):22
Researcher views on returning results from multi-omics data to research participants: insights from The Molecular Transducers of Physical Activity Consortium (MoTrPAC) Study
Ormond KE; Stanclift C; Reuter CM; Carter JN; Murphy KE; Lindholm ME; Wheeler MT
Journal article: CIRCULATION. 2024;150:a4143199
The Multi-omic, Multi-tissue Response to Acute Endurance and Resistance Exercise: Results from the Molecular Transducers of Physical Activity Consortium
Katz D; Jin C; Smith G; Clark N; Iyer G; Keshishian HK; Hart P; Sanford J; Zhang Z; Ge Y; Robbins J; Barber J; Montalvo S; Jimenez-Morales D; Lindholm M; Zhen J; Jaeger B; Sparks L; Sagendorf T; Many G; Vetr N; Raja A; Amar D; Hsu F-C; Miller M; Xia A; Fleg J; Tracy R; Gerszten R; Adkins J; Walsh M; Sealfon S; Goodpaster B; Trappe S; Burant C; Carr S; Smith K; Snyder M; Montgomery S; Ashley E; Wheeler M
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2024;137(3):473-493
Molecular Transducers of Physical Activity Consortium (MoTrPAC): human studies design and protocol
Jakicic JM; Kohrt WM; Houmard JA; Miller ME; Radom-Aizik S; Rasmussen BB; Ravussin E; Serra M; Stowe CL; Trappe S; Abouassi H; Adkins JN; Alekel DL; Ashley E; Bamman MM; Bergman BC; Bessesen DH; Broskey NT; Buford TW; Burant CF; Chen H; Christle JW; Clish CB; Coen PM; Collier D; Collins KA; Cooper DM; Cortes T; Cutter GR; Dubis G; Fernandez FM; Firnhaber J; Forman DE; Gaul DA; Gay N; Gerszten RE; Goodpaster BH; Gritsenko MA; Haddad F; Huffman KM; Ilkayeva O; Jankowski CM; Jin C; Johannsen NM; Johnson J; Kelly L; Kershaw E; Kraus WE; Laughlin M; Lester B; Lindholm ME; Lowe A; Lu C-J; McGowan J; Melanson EL; Montgomery S; Moore SG; Moreau KL; Muehlbauer M; Musi N; Nair VD; Newgard CB; Newman AB; Nicklas B; Nindl BC; Ormond K; Piehowski PD; Qian W-J; Rankinen T; Rejeski WJ; Robbins J; Rogers RJ; Rooney JL; Rushing S; Sanford JA; Schauer IE; Schwartz RS; Sealfon SC; Slentz C; Sloan R; Smith KS; Snyder M; Spahn J; Sparks LM; Stefanovic-Racic M; Tanner CJ; Thalacker-Mercer A; Tracy R; Trappe TA; Volpi E; Walsh MJ; Wheeler MT; Willis L
Article: FUNCTION. 2024;5(4):zqae014
Physiological Adaptations to Progressive Endurance Exercise Training in Adult and Aged Rats: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC)
Schenk S; Sagendorf TJ; Many GM; Lira AK; de Sousa LGO; Bae D; Cicha M; Kramer KS; Muehlbauer M; Hevener AL; Rector RS; Thyfault JP; Williams JP; Goodyear LJ; Esser KA; Newgard CB; Bodine SC
Article: BMC BIOLOGY. 2024;22(1):147
DNA methylation of exercise-responsive genes differs between trained and untrained men
Geiger C; Needhamsen M; Emanuelsson EB; Norrbom J; Steindorf K; Sundberg CJ; Reitzner SM; Lindholm ME
Article: CELL GENOMICS. 2024;4(6):100421
Molecular adaptations in response to exercise training are associated with tissue-specific transcriptomic and epigenomic signatures
Nair VD; Pincas H; Smith GR; Zaslavsky E; Ge Y; Amper MAS; Vasoya M; Chikina M; Sun Y; Raja AN; Mao W; Gay NR; Esser KA; Smith KS; Zhao B; Wiel L; Singh A; Lindholm ME; Amar D; Montgomery S; Snyder MP; Walsh MJ; Sealfon SC
Article: CELL METABOLISM. 2024;36(6):1411-1429.e10
The mitochondrial multi-omic response to exercise training across rat tissues
Amar D; Gay NR; Jimenez-Morales D; Beltran PMJ; Ramaker ME; Raja AN; Zhao B; Sun Y; Marwaha S; Gaul DA; Hershman SG; Ferrasse A; Xia A; Lanza I; Fernandez FM; Montgomery SB; Hevener AL; Ashley EA; Walsh MJ; Sparks LM; Burant CF; Rector RS; Thyfault J; Wheeler MT; Goodpaster BH; Coen PM; Schenk S; Bodine SC; Lindholm ME
Article: NATURE. 2024;629(8010):174-183
Temporal dynamics of the multi-omic response to endurance exercise training
Amar D; Gay NR; Jean-Beltran PM; Bae D; Dasari S; Dennis C; Evans CR; Gaul DA; Ilkayeva O; Ivanova AA; Kachman MT; Keshishian H; Lanza IR; Lira AC; Muehlbauer MJ; Nair VD; Piehowski PD; Rooney JL; Smith KS; Stowe CL; Zhao B; Clark NM; Jimenez-Morales D; Lindholm ME; Many GM; Sanford JA; Smith GR; Vetr NG; Zhang T; Armenteros JJA; Avila-Pacheco J; Bararpou N; Ge Y; Hou Z; Marwaha S; Presby DM; Raja AN; Savage EM; Steep A; Sun Y; Wu S; Zhen J; Bodine SC; Esser KA; Goodyear LJ; Schenk S; Montgomery SB; Fernandez FM; Sealfon SC; Snyder MP; Adkins JN; Ashley E; Burant CF; Carr SA; Clish CB; Cutter G; Gerszten RE; Kraus WE; Li JZ; Miller ME; Nair KS; Newgard C; Ortlund EA; Qian W-J; Tracy R; Wheeler MT; Dalton KP; Hastie T; Hershman SG; Samdarshi M; Teng C; Tibshirani R; Cornell E; Gagne N; May S; Bouverat B; Leeuwenburgh C; Lu C-J; Pahor M; Hsu F-C; Rushing S; Walkup MP; Nicklas B; Rejesk WJ; Williams JP; Xia A; Albertson BG; Barton ER; Booth FW; Caputo T; Cicha M; De Sousa LGO; Farrar R; Hevener AL; Hirshman MF; Jackson BE; Ke BG; Kramer KS; Lessard SJ; Makarewicz NS; Marshall AG; Nigro P; Powers S; Ramachandran K; Recto RS; Richards CZ-T; Thyfault J; Yan Z; Zang C; Amper MAS; Balci AT; Chavez C; Chikina M; Chiu R; Gritsenko MA; Guevara K; Hansen JR; Hennig KM; Hung C-J; Hutchinson-Bunch C; Jin CA; Liu X; Maner-Smith KM; Mani DR; Marjanovic N; Monroe ME; Moore RJ; Moore SG; Mundorff CC; Nachun D; Nestor MD; Nudelman G; Pearce C; Petyuk VA; Pincas H; Ramos I; Raskind AS; Rirak S; Robbins JM; Rubenstein AB; Ruf-Zamojski F; Sagendorf TJ; Seenarine N; Soni T; Uppal K; Vangeti S; Vasoya M; Vornholt A; Walsh MJ; Yu X; Zaslavsky E; Zebarjadi N; Bamman M; Bergman BC; Bessesen DH; Buford TW; Chambers TL; Coen PM; Cooper D; Haddad F; Gadde K; Goodpaste BH; Harris M; Huffman KM; Jankowsk CM; Johannsen NM; Kohr WM; Kraus WE; Lester B; Melanson EL; Moreau KL; Musi N; Newton RLJ; Radom-Aizik S; Ramaker ME; Rankinen T; Rasmussen BB; Ravussin E; Schauer IE; Schwartz RS; Sparks LM; Thalacker-Mercer A; Trappe S; Trappe TA; Volpi E
Journal article: PHYSIOLOGY. 2024;39:1914
The multi-omic response to exercise training across rat tissues: interactive tools for data dissemination through the MoTrPAC data hub
Lindholm ME; Zhen J; Amar D; Gay NR; Beltran PMJ
Journal article: NATURE COMMUNICATIONS. 2024;15(1):3346
The impact of exercise on gene regulation in association with complex trait genetics
Vetr NG; Gay NR; Adkins JN; Montgomery SB
Article: NATURE METABOLISM. 2024;6(5):963-979
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue
Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock KL; Amar D; Caputo T; Gay NR; Gaul DA; Hirshman MF; Jimenez-Morales D; Lindholm ME; Muehlbauer MJ; Vamvini M; Bergman BC; Fernandez FM; Goodyear LJ; Hevener AL; Ortlund EA; Sparks LM; Xia A; Adkins JN; Bodine SC; Newgard CB; Schenk S; Adkins JN; Armenteros JJA; Amar D; Amper MAS; Ashley E; Asokan AK; Avila-Pacheco J; Bae D; Bamman MM; Bararpour N; Barnes J; Bergman BC; Bodine SC; Buford TW; Burant CF; Caputo T; Carbone NP; Carr SA; Chambers TL; Chavez C; Chiu R; Clish CB; Cutter GR; Dasari S; Dennis C; Evans CR; Fernandez FM; Gagne N; Gaul DA; Gay NR; Ge Y; Goodpaster BH; Goodyear LJ; Gritsenko MA; Hansen JR; Hennig KM; Hevener AL; Hirshman MF; Hou Z; Huffman KM; Hung C-J; Hutchinson-Bunch C; Ilkayeva O; Ivanova AA; Beltran PMJ; Jimenez-Morales D; Jin CA; Kachman MT; Keshishian H; Kraus WE; Lanza I; Lester B; Li JZ; Lindholm ME; Lira AK; Liu X; Maner-Smith KM; Many GM; May S; Monroe MR; Montgomery S; Moore RJ; Moore SG; Muehlbauer MJ; Nachun D; Nair KS; Nair V; Raja AN; Nestor MD; Newgard CB; Nigro P; Nudelman G; Ortlund EA; Petyuk VA; Piehowski PD; Pincas H; Qian W-J; Raskind A; Rasmussen BB; Rooney JL; Rushing S; Sagendorf TJ; Samdarshi M; Sanford JA; Schenk S; Sealfon SC; Smith KS; Smith GR; Snyder M; Sparks LM; Stowe CL; Talton JW; Teng C; Thalacker-Mercer A; Tracy R; Trappe TA; Vamvini M; Vasoya M; Vetr NG; Volpi E; Walkup MP; Walsh MJ; Wheeler MT; Whytock KL; Wu S; Xia A; Zaslavsky E; Zebarjadi N; Zhang T; Zhao B; Zhen J
Article: ISCIENCE. 2024;27(1):108638
Remodeling of the human skeletal muscle proteome found after long-term endurance training but not after strength training
Emanuelsson EB; Arif M; Reitzner SM; Perez S; Lindholm ME; Mardinoglu A; Daub C; Sundberg CJ; Chapman MA
Article: AGING CELL. 2024;23(1):e13859
Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle
Voisin S; Seale K; Jacques M; Landen S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Thompson J-LM; Doering TM; Lindholm ME; Walsh C; Davison G; Irwin R; McBride C; Hansson O; Asplund O; Heikkinen AE; Piirila P; Pietilainen KH; Ollikainen M; Blocquiaux S; Thomis M; Dawn CK; Sharples AP; Eynon N
Article: ANTIOXIDANTS. 2023;12(12):2043
Comparing the Blood Response to Hyperbaric Oxygen with High-Intensity Interval Training-A Crossover Study in Healthy Volunteers
Kjellberg A; Lindholm ME; Zheng X; Liwenborg L; Rodriguez-Wallberg KA; Catrina S-B; Lindholm P
Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2021;14(6):e003419
Mono- and Biallelic Protein-Truncating Variants in Alpha-Actinin 2 Cause Cardiomyopathy Through Distinct Mechanisms
Lindholm ME; Jimenez-Morales D; Zhu H; Seo K; Amar D; Zhao C; Raja A; Madhvani R; Abramowitz S; Espenel C; Sutton S; Caleshu C; Berry GJ; Motonaga KS; Dunn K; Platt J; Ashley EA; Wheeler MT
Article: NATURE COMMUNICATIONS. 2021;12(1):3471
Time trajectories in the transcriptomic response to exercise - a meta-analysis
Amar D; Lindholm ME; Norrbom J; Wheeler MT; Rivas MA; Ashley EA
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(8):1679-1690
Exercise Induces Different Molecular Responses in Trained and Untrained Human Muscle
Moberg M; Lindholm ME; Reitzner SM; Ekblom B; Sundberg C-J; Psilander N
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2020;11(4):887-898
An epigenetic clock for human skeletal muscle
Voisin S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Doering TM; Thompson J-LM; Benedict C; Cedernaes J; Lindholm ME; Craig JM; Rowlands DS; Sharples AP; Horvath S; Eynon N
Article: CELL REPORTS. 2020;31(12):107808
Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women
Chapman MA; Arif M; Emanuelsson EB; Reitzner SM; Lindholm ME; Mardinoglu A; Sundberg CJ
Article: CONTEMPORARY CLINICAL TRIALS COMMUNICATIONS. 2018;10:148-153
Metabolic and functional changes in transgender individuals following cross-sex hormone treatment: Design and methods of the GEnder Dysphoria Treatment in Sweden (GETS) study
Wiik A; Andersson DP; Brismar TB; Chanpen S; Dhejne C; Ekstrom TJ; Flanagan JN; Holmberg M; Kere J; Lilja M; Lindholm ME; Lundberg TR; Maret E; Melin M; Olsson SM; Rullman E; Wahlen K; Arver S; Gustafsson T
Article: NATURE COMMUNICATIONS. 2018;9(1):1612
Medical relevance of protein-truncating variants across 337,205 individuals in the UK Biobank study
DeBoever C; Tanigawa Y; Lindholm ME; McInnes G; Lavertu A; Ingelsson E; Chang C; Ashley EA; Bustamante CD; Daly MJ; Rivas MA
Article: PLOS GENETICS. 2016;12(9):e1006294
The Impact of Endurance Training on Human Skeletal Muscle Memory, Global Isoform Expression and Novel Transcripts
Lindholm ME; Giacomello S; Solnestam B; Fischer H; Huss M; Kjellqvist S; Sundberg CJ
Article: EXPERIMENTAL PHYSIOLOGY. 2016;101(1):28-32
Skeletal muscle hypoxia-inducible factor-1 and exercise
Lindholm ME; Rundqvist H
Article: BMC GENOMICS. 2015;16(1):475
The human cardiac and skeletal muscle proteomes defined by transcriptomics and antibody-based profiling
Lindskog C; Linne J; Fagerberg L; Hallstrom BM; Sundberg CJ; Lindholm M; Huss M; Kampf C; Choi H; Liem DA; Ping P; Varemo L; Mardinoglu A; Nielsen J; Larsson E; Ponten F; Uhlen M
Article: EPIGENETICS. 2014;9(12):1557-1569
An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training
Lindholm ME; Marabita F; Gomez-Cabrero D; Rundqvist H; Ekstrom TJ; Tegner J; Sundberg CJ
Article: FASEB JOURNAL. 2014;28(10):4571-4581
The human skeletal muscle transcriptome: sex differences, alternative splicing, and tissue homogeneity assessed with RNA sequencing
Lindholm ME; Huss M; Solnestam BW; Kjellqvist S; Lundeberg J; Sundberg CJ
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2014;307(3):R248-R255
Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism
Lindholm ME; Fischer H; Poellinger L; Johnson RS; Gustafsson T; Sundberg CJ; Rundqvist H
Article: EPIGENETICS. 2013;8(3):333-346
An evaluation of analysis pipelines for DNA methylation profiling using the Illumina HumanMethylation450 BeadChip platform
Marabita F; Almgren M; Lindholm ME; Ruhrmann S; Fagerstrom-Billai F; Jagodic M; Sundberg CJ; Ekstrom TJ; Teschendorff AE; Tegner J; Gomez-Cabrero D
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All other publications

Preprint: BIORXIV. 2025;BIORXIV
Multi-omic identification of key transcriptional regulatory programs during endurance exercise training in rats.
Smith GR; Zhao B; Lindholm ME; Raja A; Viggars M; Pincas H; Gay NR; Sun Y; Ge Y; Nair VD; Sanford JA; Amper MAS; Vasoya M; Smith KS; Montgomery S; Zaslavsky E; Bodine SC; Esser KA; Walsh MJ; Snyder MP; Sealfon SC; MoTrPAC Study Group
Preprint: BIORXIV. 2025;BIORXIV
Endurance exercise drives temporal and sexual dimorphic multi-omic adaptations in liver metabolism-Findings from MoTrPAC.
Kelty TJ; Franczak E; Gay NR; Many GM; Sagendorf TJ; Sanford JA; Hou Z; Gaul DA; Fernández FM; Burant C; Hevener AL; Adkins JN; Bodine S; Lindholm ME; Ortlund EA; Schenk S; Thyfault JP; Rector RS
Preprint: BIORXIV. 2025
Sexually distinct multi-omic responses to progressive endurance exercise training in the rat lung—Findings from MoTrPAC
Many G; Sagendorf T; Mitchell H; Sanford J; Cohen S; Misra R; Estevao I; Ludovico ID; Gaul D; Lindholm M; Ushakumary M; Pino J; Musi N; Nie J; Fernández F; Ortlund E; Esser K; Bodine S; Schenk S; Clair G; Adkins J; The MoTrPAC Study Group
Review: PHYSIOLOGY. 2025;40(2):0-202
Charting the Molecular Terrain of Exercise: Energetics, Exerkines, and the Future of Multiomic Mapping
Katz DH; Lindholm ME; Ashley EA
Preprint: MEDRXIV. 2024
Researcher Views on Multi-omics Return of Results to Research Participants: Insights from the Molecular Transducers of Physical Activity Consortium (MoTrPAC) Study
Ormond K; Stanclift C; Reuter C; Carter J; Murphy K; Lindholm M; Wheeler M
Conference publication: PHYSIOLOGY. 2024;39:646
Remodeling of the Human Skeletal Muscle Proteome Found After Long -Term Endurance Training but Not After Strength Training
Emanuelsson E; Arif M; Reitzner S; Perez S; Lindholm M
Preprint: BIORXIV. 2023;BIORXIV
Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.
Many GM; Sanford JA; Sagendorf TJ; Hou Z; Nigro P; Whytock K; Amar D; Caputo T; Gay NR; Gaul DA; Hirshman M; Jimenez-Morales D; Lindholm ME; Muehlbauer MJ; Vamvini M; Bergman B; Fern Ndez FM; Goodyear LJ; Ortlund EA; Sparks LM; Xia A; Adkins JN; Bodine SC; Newgard CB; Schenk S; MoTrPAC Study Group
Preprint: BIORXIV. 2023;BIORXIV
The mitochondrial multi-omic response to exercise training across tissues.
Amar D; Gay NR; Jimenez-Morales D; Beltran PMJ; Ramaker ME; Raja AN; Zhao B; Sun Y; Marwaha S; Gaul D; Hershman SG; Xia A; Lanza I; Fernandez FM; Montgomery SB; Hevener AL; Ashley EA; Walsh MJ; Sparks LM; Burant CF; Rector RS; Thyfault J; Wheeler MT; Goodpaster BH; Coen PM; Schenk S; Bodine SC; Lindholm ME; MoTrPAC Study Group
Preprint: BIORXIV. 2022
Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle
Voisin S; Seale K; Jacques M; Landen S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Thompson J-LM; Doering TM; Lindholm ME; Walsh C; Davison G; Irwin R; McBride C; Hansson O; Asplund O; Heikkinen AE; Piirilä P; Pietiläinen KH; Ollikainen M; Blocquiaux S; Thomis M; Coletta DK; Sharples AP; Eynon N
Preprint: BIORXIV. 2022
Temporal dynamics of the multi-omic response to endurance exercise training across tissues
Group MS; Amar D; Gay NR; Beltran PMJ; Adkins JN; Armenteros JJA; Ashley E; Avila-Pacheco J; Bae D; Bararpour N; Burant C; Clish C; Cutter G; Dasari S; Dennis C; Evans CR; Fernández FM; Gaul D; Ge Y; Gerszten R; Goodyear LJ; Hou Z; Ilkayeva O; Ivanova AA; Jimenez-Morales D; Kachman MT; Keshishian H; Kraus WE; Lanza IR; Li J; Lindholm ME; Lira AC; Many GM; Marwaha S; Miller ME; Muehlbauer MJ; Nair KS; Nair VD; Raja AN; Newgard C; Ortlund EA; Piehowski PD; Presby DM; Qian W-J; Rooney JL; Sanford JA; Savage E; Sealfon SC; Smith GR; Smith KS; Steep A; Stowe CL; Sun Y; Tracy R; Vetr NG; Walsh MJ; Wu S; Zhang T; Zhao B; Zhen J; Albertson BG; Amper MAS; Balci AT; Bamman M; Barton ER; Bergman B; Bessesen D; Booth F; Bouverat B; Buford TW; Caputo T; Chambers TL; Chavez C; Chikina M; Chiu R; Cicha M; Coen PM; Cooper D; Cornell E; Dalton KP; De Sousa LO; Farrar R; Gadde K; Gagne N; Goodpaster BH; Gritsenko MA; Guevara K; Haddad F; Hansen JR; Harris M; Hastie T; Hennig KM; Hershman SG; Hevener A; Hirshman MF; Hsu F-C; Huffman KM; Hung C-J; Hutchinson-Bunch C; Jackson BE; Jankowski C; Jin CA; Johannsen NM; Ke BG; Kohrt WM; Kramer KS; Leeuwenburgh C; Lessard SJ; Lester B; Liu X; Lu C-J; Makarewicz NS; Maner-Smith KM; Mani; Marjanovic N; Marshall A; May S; Melanson E; Monroe ME; Moore RJ; Moore S; Moreau KL; Mundorff CC; Musi N; Nachun D; Nestor MD; Newton RL; Nicklas B; Nigro P; Nudelman G; Pahor M; Pearce C; Petyuk VA; Pincas H; Powers S; Radom-Aizik S; Ramachandran K; Ramaker ME; Ramos I; Rankinen T; Raskind A; Rasmussen BB; Ravussin E; Rector RS; Rejeski WJ; Richards C; Rirak S; Robbins JM; Rubenstein AB; Ruf-Zamojski F; Rushing S; Sagendorf TJ; Samdarshi M; Schauer IE; Schwartz R; Seenarine N; Soni T; Sparks LM; Teng C; Thalacker-Mercer A; Thyfault J; Tibshirani R; Trappe S; Trappe TA; Uppal K; Vangeti S; Vasoya M; Volpi E; Vornholt A; Walkup MP; Williams J; Xia A; Yan Z; Yu X; Zang C; Zaslavsky E; Zebarjadi N; Bodine SC; Carr S; Esser K; Montgomery SB; Schenk S; Snyder MP; Wheeler MT
Conference publication: ACTA PHYSIOLOGICA. 2022;236:57
Do muscles have memory?Molecular effects of training, detraining and retraining
Lindholm ME
Preprint: BIORXIV. 2020
Mono- and bi-allelic protein truncating variants in alpha-actinin 2 cause cardiomyopathy through distinct mechanisms
Lindholm M; Jimenez-Morales D; Zhu H; Seo K; Amar D; Zhao C; Raja A; Madhvani R; Espenel C; Sutton S; Caleshu C; Berry G; Motonaga K; Dunn K; Platt J; Ashley E; Wheeler M
Conference publication: CIRCULATION. 2020;142(Suppl_3)
Abstract 14355: Mono- and Biallelic Structural Variants in Alpha-actinin 2 Cause Contractile Dysfunction and Cardiomyopathy in Humans
Lindholm ME; Zhu H; Seo K; Jimenez-Morales D; Zhao C; Ashley EA; Wheeler MT
Conference publication: CIRCULATION. 2020;142
Mono- and Biallelic Structural Variants in Alpha-actinin 2 Cause Contractile Dysfunction and Cardiomyopathy in Humans
Lindholm ME; Zhu H; Seo K; Jimenez-Morales D; Zhao C; Ashley EA; Wheeler MT
Review: CELL. 2020;181(7):1464-1474
Molecular Transducers of Physical Activity Consortium (MoTrPAC): Mapping the Dynamic Responses to Exercise
Sanford JA; Nogiec CD; Lindholm ME; Adkins JN; Amar D; Dasari S; Drugan JK; Fernandez FM; Radom-Aizik S; Schenk S; Snyder MP; Tracy RP; Vanderboom P; Trappe S; Walsh MJ
Preprint: BIORXIV. 2019
Differential response trajectories to acute exercise in blood and muscle
Amar D; Lindholm M; Norrbom J; Wheeler M; Rivas M; Ashley E
Preprint: BIORXIV. 2019
An epigenetic clock for human skeletal muscle
Voisin S; Harvey NR; Haupt LM; Griffiths LR; Ashton KJ; Coffey VG; Doering TM; Thompson JM; Benedict C; Cedernaes J; Lindholm ME; Craig JM; Rowlands DS; Sharples AP; Horvath S; Eynon N
Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1310
Structural variants in Alpha-actinin 2 are associated with cardiomyopathy and hypertrophy in human cardiac tissue and iPSC-derived cardiomyocytes
Lindholm ME; Zhu H; Huang Y; Ashley EA; Wheeler M
Conference publication: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2019;73(9):1027
NOVEL ALPHA-ACTININ 2 MUTATIONS ARE ASSOCIATED WITH CARDIOMYOPATHY AND HYPERTROPHY IN HUMAN CARDIAC TISSUE AND IPSC-DERIVED CARDIOMYOCYTES
Lindholm M; Zhu H; Huang Y; Ashley EA; Wheeler M
Preprint: SSRN ELECTRONIC JOURNAL. 2019
Differential Response Trajectories to Acute Exercise in Blood and Muscle
Amar D; Lindholm ME; Norrbom J; Wheeler MT; Rivas M; Ashley EA
Conference publication: FASEB JOURNAL. 2016;30
Endurance Training Alters Expression of Over 3000 Isoforms and 34 Novel Transcripts in Human Skeletal Muscle
Lindholm M; Giacomello S; Solnestam BW; Fischer H; Kjellqvist S; Huss M; Sundberg CJ
Doctoral thesis: 2015
The search for human skeletal muscle memory : exercise effects on the transcriptome and epigenome
Lindholm M
Conference publication: ACTA PHYSIOLOGICA. 2014;211:38
The human skeletal muscle transcriptome - sex differences, alternative splicing and tissue homogeneity assessed with RNA sequencing
Lindholm ME; Huss M; Solnestam BW; Kjellqvist S; Lundeberg J; Sundberg CJ
Conference publication: FASEB JOURNAL. 2013;27(S1):1134.1
Endurance training changes the DNA methylation pattern in human skeletal muscle
Lindholm ME; Marabita F; Gomez‐Cabrero D; Fischer H; Tegnér J; Sundberg CJ
Conference publication: FASEB JOURNAL. 2012;26:1086.11
Variation of global mRNA expression in biopsies from the same human muscle
Sundberg CJB; Lindholm M; Solnestam BW; Lundberg J; Fischer H
Conference publication: FASEB JOURNAL. 2012;26:533.3
Human skeletal muscle histone modifications in response to six weeks of endurance training
Ydfors M; Lindholm M; Sundberg CJ
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Grants

Exercise-induced cardiac adaptation in hypertrophic cardiomyopathy
National Heart Lung and Blood Institute
1 July 2022 - 31 August 2024
Genome-scale mechanisms of adaptation in long-term exercise trained humans – skeletal muscle and adipose tissue crosstalk assessed through spatial transcriptomics analysis
Swedish Research Council
1 January 2019 - 31 December 2021

Employments

Affiliated to Research, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2026

Degrees and Education

Degree Of Doctor Of Philosophy, Department of Physiology and Pharmacology, Karolinska Institutet, 2015
Master Of Medical Science, Karolinska Institutet, 2009

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