Magnus Wickman
Professor Emeritus/Emerita | Docent
E-postadress: magnus.wickman@ki.se
Besöksadress: Nobels väg 13, 17177 Stockholm
Postadress: C6 Institutet för miljömedicin, C6 Miljömedicinsk epidemiologi Bergström, 171 77 Stockholm
Om mig
- MD, PhD, professor emeritus i pediatrisk allergologi.
Erhöll Stora priset från Svenska föreningen för allergi 2012
Forskningsbeskrivning
- Utveckling av allergisjukdom bland barn och ungdomar.
Sedan slutet av 80-talet pågår arbete med att dels kartlägga förekomsten av olika allergisjukdomar i landet och förändringar över tid, allergisjukdomars naturliga förlopp och riskfaktorer avseende dessa. Forskningen kan beskrivas som kliniskt inriktad, dvs patientnära och med möjligeter till direkt implementering i den unga befolkningen.
Forskningen utgår från en födelsekohort bland barn som startades 1994. Studien fick namnet BAMSE (Barn, Allergi, Miljö, Stockholm, en Epidemiologisk studie) Studien kom att inkludera drygt 4000 nyfödda barn samtliga boende i Stockholm. Upprepade uppföljningar har skett inkluderande undersökningar och provtagningar, och den senaste som avslutades 2012 då barnen, numera ungdomar, var 16 år och med fortsatt hög svarsfrekvens (78%). Områden som har belysts är tidiga exponeringsfaktorers betydelse för utveckling av allergi, allergisnuva, eksem och astma samt lungfunktion.
Faktorer som studerats har varit ärftlighet inklusive genetiska markörer, tidiga infektioner och kostfaktorer inklusive bröstmjölk, luftföroreningar såsom exponering för tobaksrök, luftföroreningar från inomhusmiljön och biltrafik. Betydelsen av tidig exponering för allergen har också studerats. Stor vikt har lagts vad gäller skillnader mellan kön och socio-ekonomiska faktorer.
Allergisk sensibilisering och födoämnesallergi
Vi forskar även på hur allergisk sensibilisering förändras i relation till uttryck för allergisjukdom, inte minst mot allergen mot olika födoämnen och då i synnerhet jordnötter och olika trädnötter. Vi belyser detta område dels utifrån data utgående från BAMSE-studien, dels i samarbete med Sachsska Barnsjukhuset i Stockholm där vi använder oss av rent kliniska material. Vi använder oss av en högteknologisk metod för att mäta förekomst av allergiantikroppar i serum, vilket medfört att vi nu kan studera 140 proteinmolekyler från växt- och djurlivet och deras roll i bildandet av allergiantikroppar.
Samarbete pågår med olika forskargrupper inom KI kopplade till Centrum för Allergiforskning, Stockholms Universitet samt forskare i Norge, Tyskland, Hollan, England, Irland och Spanien. BAMSE har ingått i 5 större EU projekt (AirAllerg, GA2LEN, GABRIEL, ENRIECO och MeDALL). Forskargruppen består av läkare, sjuksköterskor, biomedicinsk analytiker, datasamordnare/databashanterare och statistiker.
Artiklar
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(6):1693-1699
- Article: EBIOMEDICINE. 2017;26:91-99
- Article: ALLERGY. 2017;72(10):1475-1484
- Article: ALLERGY. 2017;72(10):1548-1555
- Article: ALLERGY. 2017;72(8):1261-1266
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(6):751-759
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):643-654.e6
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(2):388-399
- Article: JOURNAL OF NUTRITION HEALTH & AGING. 2017;21(1):92-104
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(12):1575-1587
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2016;27(7):728-735
- Article: ALLERGY. 2016;71(9):1357-1361
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;138(2):367-374.e2
- Article: ALLERGY. 2016;71(8):1219-1222
- Article: INDOOR AIR. 2016;26(3):403-413
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2016;27:1-250
- Article: ALLERGY. 2016;71(5):677-683
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2016;98(4):680-696
- Article: PEDIATRICS. 2016;137(4):e20152056
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2016;27(2):126-133
- Article: ALLERGY. 2016;71(3):333-341
- Article: ALLERGY. 2016;71(3):342-349
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2016;137(3):813-21.e7
- Article: ALLERGY. 2016;71(2):239-248
- Article: PLOS ONE. 2016;11(11):e0166347
- Article: ALLERGY. 2015;70(11):1372-1392
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;136(5):1247-53.e1-2-1253.e2
- Article: PEDIATRIC PULMONOLOGY. 2015;50(10):978-986
- Article: ALLERGY. 2015;70(9):1181-1183
- Article: ALLERGY. 2015;70(9):1062-1078
- Article: LANCET RESPIRATORY MEDICINE. 2015;3(8):613-620
- Article: ALLERGY. 2015;70(8):973-984
- Article: ALLERGY. 2015;70(7):820-827
- Article: ALLERGY. 2015;70(6):638-652
- Article: THORAX. 2015;70(6):595-597
- Article: LAKARTIDNINGEN. 2015;112:DHWL
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2015;26(3):239-246
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;135(5):1199-206.e1-11-U592
- Article: CLINICAL AND MOLECULAR ALLERGY. 2015;13(1):5
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2015;167(1):57-64
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2015;135(1):102-109
- Article: ALLERGY. 2014;69(11):1506-1514
- Article: PEDIATRICS. 2014;134(3):428-434
- Article: EUROPEAN RESPIRATORY JOURNAL. 2014;44(2):304-323
- Article: ALLERGY. 2014;69(8):1046-1057
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2014;25(4):380-386
- Article: NEUROGASTROENTEROLOGY AND MOTILITY. 2014;26(6):841-850
- Article: HEALTH. 2014;18(2):130-145
- Article: METHODS. 2014;66(1):106-119
- Article: LANCET RESPIRATORY MEDICINE. 2014;2(2):131-140
- Article: JOURNAL OF OBESITY. 2014;2014:406529-10
- Article: PLOS ONE. 2014;9(10):e109519
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2014;44(1):113-120
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2014;163(3):215-224
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2013;43(12):1309-1332
- Article: ALLERGY. 2013;68(12):1571-1578
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2013;97(6):1324-1330
- Article: BRITISH JOURNAL OF DERMATOLOGY. 2013;168(3):588-594
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2012;186(10):1037-1043
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;130(5):1049-1062
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2012;42(10):1491-1500
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;130(2):468-472
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;130(1):83-90.e4
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2012;42(4):568-577
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(4):943-54.e4
- Article: ALLERGY. 2012;67(4):537-544
- Article: LAKARTIDNINGEN. 2012;109(12):622-624
- Article: THORAX. 2012;67(3):215-221
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(2):403-408
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2012;23(1):75-82
- Article: GENES AND IMMUNITY. 2012;13(1):59-65
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2012;158(3):216-231
- Article: PEDIATRICS. 2012;129(1):70-76
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(1):240-246
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2012;42(1):30-37
- Article: ALLERGY. 2012;67(1):18-24
- Article: INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY. 2012;159(2):209-212
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2011;22(4):369-373
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;127(5):1219-1225
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;127(3):603-607
- Article: ALLERGY. 2010;65(10):1212-1221
- Article: BIOLOGICAL PSYCHIATRY. 2010;68(5):474-483
- Article: ALLERGY. 2010;65(9):1189-1195
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2010;40(8):1230-1237
- Article: ALLERGY. 2010;65(6):681-689
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;125(5):1013-1019
- Article: PEDIATRIC PULMONOLOGY. 2010;45(4):341-348
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2010;40(3):458-467
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2010;21(2):277-283
- Article: ALLERGY. 2010;65(2):213-219
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2009;361(27):2599-2608
- Article: AMERICAN JOURNAL OF CLINICAL NUTRITION. 2009;90(6):1693-1698
- Article: ALLERGY. 2009;64(7):969-977
- Article: JOURNAL OF MEDICAL GENETICS. 2009;46(3):159-167
- Article: ALLERGY. 2008;63(11):1491-1498
- Article: ALLERGY. 2008;63(11):1499-1504
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2008;38(9):1507-1513
- Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2008;116(8):1077-1084
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2008;38(8):1325-1332
- Article: INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH. 2008;211(3-4):337-344
- Article: HUMAN MOLECULAR GENETICS. 2008;17(11):1673-1682
- Article: EPIDEMIOLOGY. 2008;19(3):401-408
- Article: ALLERGY. 2008;63(4):418-424
- Article: ALLERGY. 2008;63(2):211-218
- Article: THORAX. 2008;63(2):172-176
- Article: ACTA PAEDIATRICA. 2008;97(1):85-90
- Article: ARCHIVES OF DISEASE IN CHILDHOOD. 2007;92(10):881-886
- Article: EUROPEAN RESPIRATORY JOURNAL. 2007;29(6):1144-1153
- Article: THORAX. 2006;61(12):1054-1058
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;118(6):1299-1304
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2006;36(11):1391-1398
- Article: ACTA PAEDIATRICA. 2006;95(10):1191-1196
- Article: ALLERGY. 2006;61(9):1104-1111
- Article: ALLERGY. 2006;61(8):1009-1015
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2006;36(6):722-727
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2006;78(6):1060-1065
- Article: ALLERGY. 2006;61(5):640-647
- Article: ALLERGY. 2006;61(4):414-421
- Article: ALLERGY. 2006;61(2):221-228
- Article: RESPIRATORY RESEARCH. 2006;7(1):3
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2005;35(8):1033-1039
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2005;171(10):1089-1095
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2005;35(5):612-618
- Article: ALLERGY. 2005;60(5):650-657
- Article: JOURNAL OF MEDICAL GENETICS. 2004;41(12):e123
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;114(6):1434-1440
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;114(4):755-760
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2004;15(4):291-307
- Article: ACTA PAEDIATRICA. 2004;93(7):899-905
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2004;34(6):839-844
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2004;15(3):196-205
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2004;15(2):103-111
- Article: INDOOR AIR. 2004;14(1):34-42
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2003;14(6):441-447
- Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2003;60(11):876-881
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2003;33(9):1226-1231
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2003;33(9):1190-1197
- Article: ALLERGY. 2003;58(8):742-747
- Article: PEDIATRIC INFECTIOUS DISEASE JOURNAL. 2003;22(7):642-647
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2003;111(4):800-806
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2003;14(1):18-26
- Article: ARCHIVES OF DISEASE IN CHILDHOOD. 2002;87(6):478-481
- Article: EUROPEAN RESPIRATORY JOURNAL. 2002;20(3):646-650
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2002;13(3):182-187
- Article: ACTA DERMATO-VENEREOLOGICA. 2002;82(2):98-103
- Article: LAKARTIDNINGEN. 2001;98(49):5656-5660
- Article: ALLERGY. 2001;56(8):771-774
- Article: ALLERGY. 2001;56(7):646-652
- Article: EUROPEAN RESPIRATORY JOURNAL. 2001;17(6):1151-1157
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2001;163(3):694-698
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2000;30(3):418-425
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1999;29(12):1648-1654
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1999;104(4):755-762
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1999;103(6):1012-1017
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1999;29(5):626-632
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 1999;10(1):21-26
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1998;28(11):1389-1396
- Article: ALLERGY. 1998;53(10):957-961
- Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 1998;9(1):31-35
- Article: EUROPEAN RESPIRATORY JOURNAL. 1998;11(2):366-370
- Article: ALLERGY. 1997;52(11):1123-1127
- Article: ALLERGY. 1996;51(7):511-513
- Article: ARCHIVES OF DISEASE IN CHILDHOOD. 1995;73(5):408-412
- Article: ALLERGY. 1995;50(2):106-112
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Alla övriga publikationer
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;140(2):587-590.e7
- Review: ALLERGY. 2017;72(6):857-865
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(4):1407-1408
- Corrigendum: CLINICAL AND TRANSLATIONAL ALLERGY. 2017;7:5
- Review: CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(11):1389-1397
- Review: CLINICAL AND EXPERIMENTAL ALLERGY. 2016;46(10):1248-1257
- Review: LAKARTIDNINGEN. 2016;113:DTED
- Review: CLINICAL AND TRANSLATIONAL ALLERGY. 2016;6:29
- Review: CLINICAL AND TRANSLATIONAL ALLERGY. 2016;6:47
- Letter: ALLERGY. 2015;70(9):1190-1191
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;136(2):512-4.e6
- Editorial comment: ALLERGY. 2015;70(4)
- Review: WORLD ALLERGY ORGANIZATION JOURNAL. 2015;8(1):31
- Review: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2014;25(6):516-533
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;133(2):594-596
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;133(2):580-582
- Review: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2013;24(2):195-209
- Review: ENVIRONMENTAL HEALTH. 2013;12:8
- Review: ALLERGY. 2011;66(5):596-604
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2010;125(4):941-943
- Meeting abstract: EPIDEMIOLOGY. 2009;20(6):S34
- Review: ALLERGY. 2008;63(8):981-989
- Published conference paper: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2008;19:4-16
- Review: ALLERGY. 2008;63(7):842-853
- Review: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2008;19(1):1-4
- Review: RHINOLOGY. 2007;45(2):112-121
- Meeting abstract: EPIDEMIOLOGY. 2006;17(6):S148
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2005;115(6):1324-1325
- Published conference paper: ALLERGY. 2005;60:14-18
- Published conference paper: ALLERGY. 2004;59:30-31
- Review: LAKARTIDNINGEN. 2004;101(21-22):1916-1919
- Editorial comment: ALLERGY. 2003;58(7):570-571
- Review: MONALDI ARCHIVES FOR CHEST DISEASE. 2002;57(2):113-114
- Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):S267
- Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;109(1):S136
- Published conference paper: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2002;13(s15):11-13
- Editorial comment: ALLERGY. 2001;56(4):267-269
- Letter: LANCET. 2001;357(9261):1042
- Editorial comment: ALLERGY. 2000;55(7):589-590
- Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2000;105(1):S104
- Meeting abstract: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2000;105(1):S80
- Editorial comment: ALLERGY. 1998;53(11):1011-1012
- Review: ALLERGY. 1997;52(4):369-373
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Anställningar
- Professor Emeritus/Emerita, Institutet för miljömedicin, Karolinska Institutet, 2022-2024
Examina och utbildning
- Docent, Inriktning: pediatrik, Karolinska Institutet, 1999