Leif Stenke

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

* specialist i invärtesmedicin och hematologi, docent vid KI. Han är
biträdande programdirektör för Socialstyrelsens Kunskapscentrum för
strålningsmedicin vid katastrofer (KcRN) som är en beredskapsfunktion
vid Centrum för strålningsmedicin.
* medlem i Socialstyrelsens medicinska expertgrupp för radiologiska och
nukleära händelser (RN-MeG). Han är också ledamot i Karolinska
Universitetssjukhusets strålskyddskommitté.

Forskningsbeskrivning

Stenkes forskning är inriktad mot studier av normal och förändrad blod-
och benmärgsfunktion vid sjukdomar och skador. Speciellt intresse riktas mot
myeloiska leukemier och inverkan av olika läkemedel och andra cellhämmande
agens, såsom joniserande strålning, på blodbildningen. Benmärgen,
kroppens ”blodfabrik”, är vårt känsligaste organ vad gäller effekt av
joniserande strålning. Om en människa utsätts för en hög stråldos är
överlevnadschansen därför vanligen beroende på omfattning och varaktighet
av det så kallade hematopoetiska syndromet, dvs graden av hämning av blod
och benmärg. Stenkes forskning syftar bl a till att förbättra kunskapen om
de cellulära och molekylära mekanismer som styr hur cellerna förökar sig
och hur de reparerar sina skador. Man studerar i detta sammanhang även
leukemiceller och hur de påverkas av olika typer av cellhämmande terapier.
Studierna är delvis av grundforskningskaraktär, med avsikten att t ex
molekylära upptäckter och fynd i samband med leukemibehandling i
förlängningen också kan leda till nya behandlingsmöjligheter för
benmärgsskadade patienter i samband med en strålningsolycka.

Artiklar

Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2025;114(2):334-342
Loss in Overall and Quality-Adjusted Life Expectancy for Patients With Chronic-Phase Chronic Myeloid Leukemia
Chen EY-T; Dahlen T; Stenke L; Bjorkholm M; Hao S; Dickman PW; Clements MS
Article: LEUKEMIA. 2024;38(4):781-787
Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial
Flygt H; Soederlund S; Richter J; Saussele S; Koskenvesa P; Stenke L; Mustjoki S; Dimitrijevic A; Stentoft J; Majeed W; Roy L; Wolf D; Dreimane A; Gjertsen BT; Gedde-Dahl T; Ahlstrand E; Markevaern B; Hjorth-Hansen H; Janssen J; Olsson-Stroemberg U
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2023;111(4):644-654
Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions
Larfors G; Andersson P; Jesson G; Liljebris C; Brisander M; Lennernas H; Stenke L
Article: BLOOD. 2023;142(1):73-89
Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
Dolinska M; Cai H; Mansson A; Shen J; Xiao P; Bouderlique T; Li X; Leonard E; Chang M; Gao Y; Medina JP; Kondo M; Sandhow L; Johansson A-SF; Deneberg S; Soederlund S; Jaedersten M; Ungerstedt J; Tobiasson M; Ostman A; Mustjoki S; Stenke L; Le Blanc K; Hellstroem-Lindberg E; Lehmann S; Ekblom M; Olsson-Stroemberg U; Sigvarosson M; Qian H
Article: ONCOIMMUNOLOGY. 2022;11(1):2109861
IFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+CML stem/progenitor cells potentially through the upregulation of multiple key survival factors
Ujvari D; Malyukova A; Zovko A; Yektaei-Karin E; Madapura HS; Keszei M; Nagy N; Lotfi K; Bjorn N; Wallvik J; Stenke L; Salamon D
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(19):4709-4721
The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis
Carracedo M; Pawelzik S-C; Artiach G; Pouwer MG; Plunde O; Saliba-Gustafsson P; Ehrenborg E; Eriksson P; Pieterman E; Stenke L; Princen HMG; Franco-Cereceda A; Back M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(17):e152585
IFN-a with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia
Huuhtanen J; Ilander M; Yadav B; Dufva OMJ; Lahteenmaki H; Kasanen T; Klievink J; Olsson-Stromberg U; Stentoft J; Richter J; Koskenvesa P; Hoglund M; Soderlund S; Dreimane A; Porkka K; Gedde-Dahl T; Gjertsen BT; Stenke L; Myhr-Eriksson K; Markevarn B; Lubking A; Dimitrijevic A; Udby L; Bjerrum OW; Hjorth-Hansen H; Mustjoki S
Article: CELL DEATH DISCOVERY. 2022;8(1):284
Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia
Haag P; Olsson M; Forsberg J; Lindberg ML; Stenerlow B; Zong D; Kanter L; Lewensohn R; Viktorsson K; Zhivotovsky B; Stenke L
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2022;97(4):421-430
Adverse outcomes in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Follow-up of patients diagnosed 2002-2017 in a complete coverage and nationwide agnostic register study
Dahlen T; Edgren G; Ljungman P; Flygt H; Richter J; Olsson-Stromberg U; Wadenvik H; Dreimane A; Myhr-Eriksson K; Zhao J; Sjalander A; Hoglund M; Stenke L
Article: JOURNAL OF RADIOLOGICAL PROTECTION. 2022;42(1):014004
The acute radiation syndrome-need for updated medical guidelines
Stenke L; Hedman C; Lindberg ML; Lindberg K; Valentin J
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2021;107(6):617-623
Long-term tolerability and efficacy after initial PegIFN-α addition to dasatinib in CML-CP: Five-year follow-up of the NordCML007 study
Flygt H; Soderlund S; Stentoft J; Richter J; Koskenvesa P; Mustjoki S; Majeed W; Lubking A; Dreimane A; Markevarn B; Stenke L; Myhr Eriksson K; Gjertsen BT; Gedde-Dahl T; Dimitrijevic A; Udby L; Olsson-Stromberg U; Hjorth-Hansen H
Article: CELL DEATH & DISEASE. 2021;12(10):875
Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells
Malyukova A; Ujvari D; Yektaei-Karin E; Zovko A; Madapura HS; Keszei M; Nagy N; Lotfi K; Bjorn N; Wallvik J; Tamai M; Nguyen TTT; Akahane K; Inukai T; Stenke L; Salamon D
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2021;193(5):915-921
Successful tyrosine kinase inhibitor discontinuation outside clinical trials - data from the population-based Swedish chronic myeloid leukaemia registry
Flygt H; Sandin F; Dahlen T; Dremaine A; Lubking A; Markevarn B; Myhr-Eriksson K; Olsson K; Olsson-Stromberg U; Sjalander A; Soderlund S; Wennstrom L; Wadenvik H; Stenke L; Hoglund M; Richter J
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2020;29(1):151-156
Increased Risk of Chronic Myeloid Leukemia Following Gastric Conditions Indicating Helicobacter pylori Infection: A Case-Control Study
Larfors G; Richter J; Sjalander A; Stenke L; Hoglund M
Article: BONE MARROW TRANSPLANTATION. 2019;54(11):1764-1774
Allogeneic stem cell transplantation for chronic myeloid leukemia in the TKI era: population-based data from the Swedish CML registry
Lubking A; Dreimane A; Sandin F; Isaksson C; Markevarn B; Brune M; Ljungman P; Lenhoff S; Stenke L; Hoglund M; Richter J; Olsson-Stromberg U
Article: ONCOIMMUNOLOGY. 2019;8(9):e1638210
Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line
Kreutzman A; Yadav B; Brummendorf TH; Gjertsen BT; Hee ML; Janssen J; Kasanen T; Koskenvesa P; Lofti K; Markevarn B; Olsson-Stromberg U; Stentoft J; Stenke L; Soderlund S; Udby L; Richter J; Hjorth-Hansen H; Mustjoki S
Article: APPLIED HEALTH ECONOMICS AND HEALTH POLICY. 2019;17(4):555-567
Cost Effectiveness of the Third-Generation Tyrosine Kinase Inhibitor (TKI) Ponatinib, vs. Second-Generation TKIs or Stem Cell Transplant, as Third-Line Treatment for Chronic-Phase Chronic Myeloid Leukemia
Hirt C; Iannazzo S; Chiroli S; McGarry LJ; le Coutre P; Stenke L; Dahlen T; Lipton JH
Article: ONCOLOGY REPORTS. 2018;40(2):902-908
Montelukast, a cysteinyl leukotriene receptor antagonist, inhibits the growth of chronic myeloid leukemia cells through apoptosis
Zovko A; Yektaei-Karin E; Salamon D; Nilsson A; Wallvik J; Stenke L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;498(3):502-508
Interferon γ is a strong, STAT1-dependent direct inducer of BCL6 expression in multiple myeloma cells
Ujvari D; Nagy N; Madapura HS; Kallas T; Krohnke MCL; Stenke L; Klein E; Salamon D
Article: LAKARTIDNINGEN. 2017;114:ER3M
[Chronic myeloid leukemia – a model disease for targeted therapy].
Richter J; Stenke L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;490(2):378-384
Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34 ⁺CD38^- stem and progenitor cells in chronic myeloid leukemia
Dolinska M; Piccini A; Wong WM; Gelali E; Johansson A-S; Klang J; Xiao P; Yektaei-Karin E; Stromberg UO; Mustjoki S; Stenke L; Ekblom M; Qian H
Article: ONCOGENE. 2017;36(32):4619-4628
Interferon γ is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells
Madapura HS; Nagy N; Ujvari D; Kallas T; Krohnke MCL; Amu S; Bjorkholm M; Stenke L; Mandal PK; McMurray JS; Keszei M; Westerberg LS; Cheng H; Xue F; Klein G; Klein E; Salamon D
Article: LEUKEMIA & LYMPHOMA. 2017;58(8):1903-1913
Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia
Yektaei-Karin E; Zovko A; Nilsson A; Nasman-Glaser B; Kanter L; Radmark O; Wallvik J; Ekblom M; Dolinska M; Qian H; Stenke L
Article: HAEMATOLOGICA. 2017;102(8):1361-1367
Single cell immune profiling by mass cytometry of newly diagnosed chronic phase chronic myeloid leukemia treated with nilotinib
Gullaksen S-E; Skavland J; Gavasso S; Tosevski V; Warzocha K; Dumrese C; Ferrant A; Gedde-Dahl T; Hellmann A; Janssen J; Labar B; Lang A; Majeed W; Mihaylov G; Stentoft J; Stenke L; Thaler J; Thielen N; Verhoef G; Voglova J; Ossenkoppele G; Hochhaus A; Hjorth-Hansen H; Mustjoki S; Sopper S; Giles F; Porkka K; Wolf D; Gjertsen BT
Article: JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY. 2017;143(8):1543-1554
Tyrosine kinase inhibitor therapy-induced changes in humoral immunity in patients with chronic myeloid leukemia
Rajala HLM; El Missiry M; Ruusila A; Koskenvesa P; Bruemmendorf TH; Gjertsen BT; Janssen J; Lotfi K; Markevarn B; Olsson-Stromberg U; Stenke L; Stentoft J; Richter J; Hjorth-Hansen H; Kreutzman A; Mustjoki S
Article: LEUKEMIA. 2017;31(5):1108-1116
Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
Ilander M; Olsson-Stromberg U; Schlums H; Guilhot J; Bruck O; Lahteenmaki H; Kasanen T; Koskenvesa P; Soderlund S; Hoglund M; Markevarn B; Sjalander A; Lotfi K; Dreimane A; Lubking A; Holm E; Bjoreman M; Lehmann S; Stenke L; Ohm L; Gedde-Dahl T; Majeed W; Ehrencrona H; Koskela S; Saussele S; Mahon F-X; Porkka K; Hjorth-Hansen H; Bryceson YT; Richter J; Mustjoki S
Article: BLOOD. 2017;129(17):2384-2394
Single-cell molecular analysis defines therapy response and immunophenotype of stem cell subpopulations in CML
Warfvinge R; Geironson L; Sommarin MNE; Lang S; Karlsson C; Roschupkina T; Stenke L; Stentoft J; Olsson-Stromberg U; Hjorth-Hansen H; Mustjoki S; Soneji S; Richter J; Karlsson G
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2017;98(4):398-406
The impact of socio-economic factors on treatment choice and mortality in chronic myeloid leukaemia
Larfors G; Sandin F; Richter J; Sjalander A; Stenke L; Lambe M; Hoglund M
Article: PLOS ONE. 2017;12(1):e0171041
Early BCR-ABL1 Transcript Decline after 1 Month of Tyrosine Kinase Inhibitor Therapy as an Indicator for Treatment Response in Chronic Myeloid Leukemia
El Missiry M; Hjorth-Hansen H; Richter J; Olson-Stromberg U; Stenke L; Porkka K; Kreutzman A; Mustjoki S
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2017;98(1):57-66
Advanced phase chronic myeloid leukaemia (CML) in the tyrosine kinase inhibitor era - a report from the Swedish CML register
Soderlund S; Dahlen T; Sandin F; Olsson-Stromberg U; Creignou M; Dreimane A; Lubking A; Markevarn B; Sjalander A; Wadenvik H; Stenke L; Richter J; Hoglund M
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2016;97(4):387-392
Population-based assessment of chronic myeloid leukemia in Sweden: striking increase in survival and prevalence
Gunnarsson N; Sandin F; Hoglund M; Stenke L; Bjorkholm M; Lambe M; Olsson-Stromberg U; Richter J; Sjalander A
Article: LEUKEMIA. 2016;30(9):1853-1860
Safety and efficacy of the combination of pegylated interferon-α2b and dasatinib in newly diagnosed chronic-phase chronic myeloid leukemia patients
Hjorth-Hansen H; Stentoft J; Richter J; Koskenvesa P; Hoeglund M; Dreimane A; Porkka K; Gedde-Dahl T; Gjertsen BT; Gruber FX; Stenke L; Eriksson KM; Markevarn B; Lubking A; Vestergaard H; Udby L; Bjerrum OW; Persson I; Mustjoki S; Olsson-Stromberg U
Article: CLINICAL CANCER RESEARCH. 2016;22(16):4030-4038
Leukemic Stem Cell Quantification in Newly Diagnosed Patients With Chronic Myeloid Leukemia Predicts Response to Nilotinib Therapy
Thielen N; Richter J; Baldauf M; Barbany G; Fioretos T; Giles F; Gjertsen B-T; Hochhaus A; Schuurhuis GJ; Sopper S; Stenke L; Thunberg S; Wolf D; Ossenkoppele G; Porkka K; Janssen J; Mustjoki S
Article: ANNALS OF INTERNAL MEDICINE. 2016;165(3):161-166
Cardiovascular Events Associated With Use of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia A Population-Based Cohort Study
Dahlen T; Edgren G; Lambe M; Hoglund M; Bjorkholm M; Sandin F; Sjalander A; Richter J; Olsson-Stromberg U; Ohm L; Back M; Stenke L
Article: LEUKEMIA. 2016;30(7):1562-1567
Increased prevalence of prior malignancies and autoimmune diseases in patients diagnosed with chronic myeloid leukemia
Gunnarsson N; Hoglund M; Stenke L; Wallberg-Jonsson S; Sandin F; Bjorkholm M; Dreimane A; Lambe M; Markevarn B; Olsson-Stromberg U; Wadenvik H; Richter J; Sjalander A
Article: LANCET ONCOLOGY. 2016;17(5):612-621
Ponatinib versus imatinib for newly diagnosed chronic myeloid leukaemia: an international, randomised, open-label, phase 3 trial
Lipton JH; Chuah C; Guerci-Bresler A; Rosti G; Simpson D; Assouline S; Etienne G; Nicolini FE; le Coutre P; Clark RE; Stenke L; Andorsky D; Oehler V; Lustgarten S; Rivera VM; Clackson T; Haluska FG; Baccarani M; Cortes JE; Guilhot F; Hochhaus A; Hughes T; Kantarjian HM; Shah NP; Talpaz M; Deininger MW
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2015;169(5):683-688
Second malignancies following treatment of chronic myeloid leukaemia in the tyrosine kinase inhibitor era
Gunnarsson N; Stenke L; Hoglund M; Sandin F; Bjorkholm M; Dreimane A; Lambe M; Markevarn B; Olsson-Stromberg U; Richter J; Wadenvik H; Wallvik J; Sjalander A
Article: LEUKEMIA & LYMPHOMA. 2015;56(5):1385-1391
Real-world cost-effectiveness in chronic myeloid leukemia: the price of success during four decades of development from non-targeted treatment to imatinib
Ohm L; Lundqvist A; Dickman P; Hoglund M; Persson U; Stenke L; Carlsson KS; Bjorkholm M
Article: MOLECULAR CANCER THERAPEUTICS. 2015;14(5):1181-1191
The Tyrosine Kinase Inhibitors Imatinib and Dasatinib Reduce Myeloid Suppressor Cells and Release Effector Lymphocyte Responses
Christiansson L; Soderlund S; Mangsbo S; Hjorth-Hansen H; Hoglund M; Markevarn B; Richter J; Stenke L; Mustjoki S; Loskog A; Olsson-Stromberg U
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2015;94(3):243-250
Dasatinib induces fast and deep responses in newly diagnosed chronic myeloid leukaemia patients in chronic phase: clinical results from a randomised phase-2 study (NordCML006)
Hjorth-Hansen H; Stenke L; Soderlund S; Dreimane A; Ehrencrona H; Gedde-Dahl T; Gjertsen BT; Hoglund M; Koskenvesa P; Lotfi K; Majeed W; Markevarn B; Ohm L; Olsson-Stromberg U; Remes K; Suominen M; Simonsson B; Porkka K; Mustjoki S; Richter J
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2015;21(3):559-564
Fate of Patients with Newly Diagnosed Acute Myeloid Leukemia Who Fail Primary Induction Therapy
Othus M; Appelbaum FR; Petersdorf SH; Kopecky KJ; Slovak M; Nevin T; Brandwein J; Larson RA; Stiff PJ; Walter RB; Tallman MS; Stenke L; Erba HP
Article: CANCER CELL. 2014;26(3):428-442
BCR-ABL1 Compound Mutations Combining Key Kinase Domain Positions Confer Clinical Resistance to Ponatinib in Ph Chromosome-Positive Leukemia
Zabriskie MS; Eide CA; Tantravahi SK; Vellore NA; Estrada J; Nicolini FE; Khoury HJ; Larson RA; Konopleva M; Cortes JE; Kantarjian H; Jabbour EJ; Kornblau SM; Lipton JH; Rea D; Stenke L; Barbany G; Lange T; Hernandez-Boluda J-C; Ossenkoppele GJ; Press RD; Chuah C; Goldberg SL; Wetzler M; Mahon F-X; Etienne G; Baccarani M; Soverini S; Rosti G; Rousselot P; Friedman R; Deininger M; Reynolds KR; Heaton WL; Eiring AM; Pomicter AD; Khorashad JS; Kelley TW; Baron R; Druker BJ; Deininger MW; O'Hare T
Article: CANCER. 2013;119(16):3076-3083
Multidrug resistance in relapsed acute myeloid leukemia: Evidence of biological heterogeneity
Patel C; Stenke L; Varma S; Lindberg ML; Bjorkholm M; Sjoberg J; Viktorsson K; Lewensohn R; Landgren O; Gottesman MM; Gillet J-P
Article: BLOOD. 2013;122(7):1284-1292
Tyrosine kinase inhibitor usage, treatment outcome, and prognostic scores in CML: report from the population-based Swedish CML registry
Hoglund M; Sandin F; Hellstrom K; Bjoreman M; Bjorkholm M; Brune M; Dreimane A; Ekblom M; Lehmann S; Ljungman P; Malm C; Markevarn B; Myhr-Eriksson K; Ohm L; Olsson-Stromberg U; Sjalander A; Wadenvik H; Simonsson B; Stenke L; Richter J
Article: LEUKEMIA. 2013;27(7):1520-1526
Impact of malignant stem cell burden on therapy outcome in newly diagnosed chronic myeloid leukemia patients
Mustjoki S; Richter J; Barbany G; Ehrencrona H; Fioretos T; Gedde-Dahl T; Gjertsen BT; Hovland R; Hernesniemi S; Josefsen D; Koskenvesa P; Dybedal I; Markevarn B; Olofsson T; Olsson-Stromberg U; Rapakko K; Thunberg S; Stenke L; Simonsson B; Porkka K; Hjorth-Hansen H
Article: BLOOD. 2013;121(24):4854-4860
A phase 3 study of gemtuzumab ozogamicin during induction and postconsolidation therapy in younger patients with acute myeloid leukemia
Petersdorf SH; Kopecky KJ; Slovak M; Willman C; Nevill T; Brandwein J; Larson RA; Erba HP; Stiff PJ; Stuart RK; Walter RB; Tallman MS; Stenke L; Appelbaum FR
Article: EXPERIMENTAL HEMATOLOGY. 2012;40(11):906-913
Killer-cell immunoglobulin-like receptor gene profile predicts good molecular response to dasatinib therapy in chronic myeloid leukemia
Kreutzman A; Jaatinen T; Greco D; Vakkila E; Richter J; Ekblom M; Hjorth-Hansen H; Stenke L; Melo T; Paquette R; Seggewiss-Bernhardt R; Guerci-Bresler A; Talbot A; Cayuela JM; Mahon F-X; Porkka K; Lipton J; Partanen J; Rousselot P; Mustjoki S
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2012;87(8):760-765
Early landmark analysis of imatinib treatment in CML chronic phase: Less than 10% BCR-ABL by FISH at 3 months associated with improved long-term clinical outcome
Ohm L; Arvidsson I; Barbany G; Hast R; Stenke L
Article: LEUKEMIA. 2011;25(10):1587-1597
Expansion of highly differentiated CD8⁺ T-cells or NK-cells in patients treated with dasatinib is associated with cytomegalovirus reactivation
Kreutzman A; Ladell K; Koechel C; Gostick E; Ekblom M; Stenke L; Melo T; Einsele H; Porkka K; Price DA; Mustjoki S; Seggewiss R
Article: LANCET ONCOLOGY. 2011;12(9):841-851
Nilotinib versus imatinib for the treatment of patients with newly diagnosed chronic phase, Philadelphia chromosome-positive, chronic myeloid leukaemia: 24-month minimum follow-up of the phase 3 randomised ENESTnd trial
Kantarjian HM; Hochhaus A; Saglio G; De Souza C; Flinn IW; Stenke L; Goh Y-T; Rosti G; Nakamae H; Gallagher NJ; Hoenekopp A; Blakesley RE; Larson RA; Hughes TP
Article: BLOOD. 2010;116(5):772-782
Mono/oligoclonal T and NK cells are common in chronic myeloid leukemia patients at diagnosis and expand during dasatinib therapy
Kreutzman A; Juvonen V; Kairisto V; Ekblom M; Stenke L; Seggewiss R; Porkka K; Mustjoki S
Article: LEUKEMIA. 2009;23(8):1398-1405
Clonal expansion of T/NK-cells during tyrosine kinase inhibitor dasatinib therapy
Mustjoki S; Ekblom M; Arstila TP; Dybedal I; Epling-Burnette PK; Guilhot F; Hjorth-Hansen H; Hoglund M; Kovanen P; Laurinolli T; Liesveld J; Paquette R; Pinilla-Ibarz J; Rauhala A; Shah N; Simonsson B; Sinisalo M; Steegmann JL; Stenke L; Porkka K
Article: EXPERIMENTAL HEMATOLOGY. 2009;37(6):755-766
Deficient activation of Bak and Bax confers resistance to gemtuzumab ozogamicin-induced apoptotic cell death in AML
Haag P; Viktorsson K; Lindberg ML; Kanter L; Lewensohn R; Stenke L
Article: JOURNAL OF PROTEOME RESEARCH. 2008;7(6):2332-2341
Proteomic data analysis workflow for discovery of candidate biomarker peaks predictive of clinical outcome for patients with acute myeloid leukemia
Forshed J; Pernemalm M; Tan CS; Lindberg M; Kanter L; Pawitan Y; Lewensohn R; Stenke L; Lehtio J
Article: LEUKEMIA & LYMPHOMA. 2006;47(9):1768-1773
Successful mobilization of Ph-negative blood stem cells with intensive chemotherapy plus G-CSF in patients with chronic myelogenous leukemia in first chronic phase
Olsson-Stromberg U; Hoglund M; Bjorkholm M; Braide I; Carlson K; Gahrton G; Grimfors G; Hast R; Lerner R; Linder O; Ljungman P; Lofvenberg E; Malm C; Nilsson P-G; Paul C; Rodjer S; Stenke L; Tidefeldt U; Turesson I; Uden A-M; Wahlin A; Vilen L; Winqvist I; Zettervall O; Oberg G; Simonsson B
Article: ACTA HAEMATOLOGICA. 2005;113(3):155-162
Intensive treatment and stem cell transplantation in chronic myelogenous leukemia:: Long-term follow-up
Simonsson B; Öberg G; Björeman M; Björkholm M; Carneskog J; Karlsson K; Gahrton G; Grimfors G; Hast R; Karle H; Linder O; Ljungman P; Nielsen JL; Nilsson J; Löfvenberg E; Malm C; Olsson K; Olsson-Strömberg U; Paul C; Stenke L; Stentoft J; Turesson I; Udén AM; Wahlin A; Vilén L; Weis-Bjerrum O
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2004;124(6):739-745
Abnormal LTC₄ synthase RNA degradation in neutrophils from CML patients
Roos C; Sjölinder M; Stenke L; Tornhamre S
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2004;350(2):114-124
Efficacy and safety of low-dose aspirin in polycythemia vera.
Landolfi R; Marchioli R; Kutti J; Gisslinger H; Tognoni G; Patrono C; Barbui T; European Collaboration on Low-Dose Aspirin in Poly
Article: LEUKEMIA RESEARCH. 2003;27(4):323-328
A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemia
Gruber A; Björkholm M; Brinch L; Evensen S; Gustavsson B; Hedenus M; Juliusson G; Löfvenberg E; Nesthus I; Simonsson B; Sjo M; Stenke L; Tangen JM; Tidefelt U; Udén AM; Paul C; Liliemark J
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2003;348(11):994-1004
Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia.
O'Brien SG; Guilhot F; Larson RA; Gathmann I; Baccarani M; Cervantes F; Cornelissen JJ; Fischer T; Hochhaus A; Hughes T; Lechner K; Nielsen JL; Rousselot P; Reiffers J; Saglio G; Shepherd J; Simonsson B; Gratwohl A; Goldman JM; Kantarjian H; Taylor K; Verhoef G; Bolton AE; Capdeville R; Druker BJ; IRIS Investigators
Article: EXPERIMENTAL HEMATOLOGY. 2003;31(2):122-130
Inverse relationship between myeloid maturation and leukotriene C₄ synthase expression in normal and leukemic myelopoiesis - consistent overexpression of the enzyme in myeloid cells from patients with chronic myeloid leukemia
Tornhamre S; Stenke L; Granzelius A; Sjölinder M; Näsman-Glaser B; Roos C; Widell S; Lindgren J
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2002;118(4):1048-1054
Intensive chemotherapy in patients with chronic myelogenous leukaemia (CML) in accelerated or blastic phase -: a report from the Swedish CML Group
Axdorph U; Stenke L; Grimfors G; Carneskog J; Hansen J; Linder O; Ljungman P; Löfvenberg E; Malm C; Simonsson B; Turesson I; Vilén L; Udén AM; Björkholm M
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2002;118(3):748-754
High-dose cytarabine in upfront therapy for adult patients with acute lymphoblastic leukaemia
Hallböök H; Simonsson B; Ahlgren T; Björkholm M; Carneskog J; Grimfors G; Hast R; Karlsson K; Kimby E; Lerner R; Linder O; Linderholm M; Löfvenberg E; Malm C; Nilsson PG; Paul C; Stenke L; Stockelberg D; Tidefelt U; Turesson I; Uden-Blome AM; Vilen L; Wahlin A; Winquist I; Smedmyr B
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2002;68(6):376-381
Long-term follow-up of patients ≥60 yr old with acute myeloid leukaemia treated with intensive chemotherapy
Öberg G; Killander A; Björeman M; Gahrton G; Grimfors G; Gruber A; Hast R; Lerner R; Liliemark J; Mattson S; Paul C; Simonsson B; Stalfelt AM; Stenke L; Tidefelt U; Udén AM; Björkholm M
Article: LAKARTIDNINGEN. 2002;99(13):1453-1455
[Management of radiation injuries--new organization, new guidelines].
Lewensohn R; Joussineau S; Stenke L
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2002;68(3):180-186
Serum erythropoietin (EPO) levels correlate with survival and independently predict response to EPO treatment in patients with myelodysplastic syndromes.
Wallvik J; Stenke L; Bernell P; Nordahl G; Hippe E; Hast R
Article: LEUKEMIA RESEARCH. 2001;25(1):13-18
Long-term follow-up of 18 patients with myelodysplastic syndromes responding to recombinant erythropoietin treatment
Hast R; Wallvik J; Folin A; Bernell P; Stenke L
Article: JOURNAL OF CLINICAL ONCOLOGY. 2000;18(9):1837-1844
P-glycoprotein inhibitor valspodar (PSC 833) increases the intracellular concentrations of daunorubicin in vivo in patients with p-glycoprotein-positive acute myeloid leukemia
Tidefelt U; Liliemark J; Gruber A; Liliemark E; Sundman-Engberg B; Juliusson G; Stenke L; Elmhorn-Rosenborg A; Möllgård L; Lehman S; Xu D; Covelli A; Gustavsson B; Paul C
Article: BLOOD. 2000;95(4):1456-1464
Aberrant expression of active leukotriene C₄ synthase in CD16⁺ neutrophils from patients with chronic myeloid leukemia
Sjölinder M; Stenke L; Näsman-Glaser B; Widell S; Doucet J; Jakobsson PJ; Lindgren J
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 1998;64(2):228-234
Expression of mRNA encoding neurotrophins and neurotrophin receptors in human granulocytes and bone marrow cells -: enhanced neurotrophin-4 expression induced by LTB₄
Laurenzi MA; Beccari T; Stenke L; Sjölinder M; Stinchi S; Lindgren J
Article: BRITISH JOURNAL OF HAEMATOLOGY. 1998;101(4):728-736
Novel enzymatic abnormalities in AML and CML in blast crisis:: elevated leucocyte leukotriene C₄ synthase activity paralleled by deficient leukotriene biosynthesis from endogenous substrate
Stenke L; Sjölinder M; Miale TD; Lindgren J
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 1997;58(4):241-245
Differences in cell lineage involvement between MDS-AML and de novo AML studied by fluorescence in situ hybridization in combination with morphology
Bernell P; Arvidsson I; Hast R; Jacobsson B; Stenke L
Article: LEUKEMIA RESEARCH. 1996;20(8):693-699
A sequential erythropoietin and GM-CSF schedule offers clinical benefits in the treatment of anaemia in myelodysplastic syndromes
Bernell P; Stenke L; Wallvik J; Hippe E; Hast R
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 1995;55(1):19-23
MITOXANTRONE, ETOPOSIDE AND ARA-C VS DOXORUBICIN-DNA, ARA-C, THIOGUANINE, VINCRISTINE AND PREDNISOLONE IN THE TREATMENT OF PATIENTS WITH ACUTE MYELOCYTIC-LEUKEMIA - A RANDOMIZED COMPARISON
BJORKHOLM M; LILIEMARK J; GAHRTON G; GRIMFORS G; GRUBER A; HAST R; JULIUSSON G; JARNMARK M; KILLANDER A; KIMBY E; LERNER R; LJUNGMAN P; LONNQVIST B; PALMBLAD J; PAUL C; PETTERSON C; SIMONSSON B; STALFELT AM; STENKE L; SUNDSTROM C; TIDEFELT U; UDEN AM; OBERG G; OST A
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Corrigendum: LEUKEMIA. 2024;38(4):925
Correction: Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial.
Flygt H; Söderlund S; Richter J; Saussele S; Koskenvesa P; Stenke L; Mustjoki S; Dimitrijevic A; Stentoft J; Majeed W; Roy L; Wolf D; Dreimane A; Gjertsen BT; Gedde-Dahl T; Ahlstrand E; Markevärn B; Hjorth-Hansen H; Janssen J; Olsson-Strömberg U
Letter: LEUKEMIA. 2023;37(5):1156-1159
The impact of Covid-19 in patients with chronic myeloid leukemia-a nationwide population-based study
Dahlen T; Flygt H; Lubking A; Olsson-Stromberg U; Wennstrom L; Dreimane A; Sjalander A; Leach S; Gisslen M; Li H; Hoglund M; Stenke L; Nyberg F
Editorial comment: JOURNAL OF RADIOLOGICAL PROTECTION. 2022;42(3):030202
To be (prepared) or not to be-that is hardly the question
Valentin J; Stenke L
Review: JOURNAL OF RADIOLOGICAL PROTECTION. 2022;42(3):031001
Mental health and psychosocial consequences linked to radiation emergencies-increasingly recognised concerns
Lagergren Lindberg M; Hedman C; Lindberg K; Valentin J; Stenke L
Letter: LEUKEMIA. 2021;35(8):2416-2418
Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR-final report from AFTER-SKI
Richter J; Lubking A; Soderlund S; Lotfi K; Markevarn B; Sjalander A; Stenke L; Deneberg S; Ahlstrand E; Myhr-Eriksson K; Panayiotidis P; Gedde-Dahl T; Zackova D; Mayer J; Olsson-Stromberg U; Mahon F-X; Saussele S; Hjorth-Hansen H; Koskenvesa P
Editorial comment: JACC: CARDIOONCOLOGY. 2020;2(1):123-126
Aortic Stenosis and the Tyrosine Kinase Inhibitor Nilotinib in Chronic Myeloid Leukemia
Carracedo M; Stenke L; Franco-Cereceda A; Back M
Published conference paper: RADIATION PROTECTION DOSIMETRY. 2018;182(1):80-84
COORDINATION OF MANAGEMENT OF THE ACUTE RADIATION SYNDROME
Stenke L; Lindberg K; Lindberg ML; Lewensohn R; Valentin J; Powles R; Dainiak N
Letter: LEUKEMIA. 2017;31(8):1825-1827
No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: a population-based study in Sweden
Gunnarsson N; Hoglund M; Stenke L; Sandin F; Bjorkholm M; Dreimane A; Lambe M; Markevarn B; Olsson-Stromberg U; Wadenvik H; Richter J; Sjalander A
Published conference paper: RADIATION PROTECTION DOSIMETRY. 2016;171(1):134-138
Lessons Learnt from the Fukushima Accident-A Swedish Medical Preparedness Perspective
Stenke L; von Schreeb J; Simonsson M; Johansson J; Postgard P; Sigurdsson S; Ljungquist A; Lindberg ML
Published conference paper: RADIATION PROTECTION DOSIMETRY. 2016;171(1):144-155
Using the Grade Approach to Support the Development of Recommendations for Public Health Interventions in Radiation Emergencies
Carr Z; Clarke M; Akl EA; Schneider R; Murith C; Li C; Parrish-Sprowl J; Stenke L; Cui-Ping L; Bertrand S; Miller C
Letter: JOURNAL OF CLINICAL ONCOLOGY. 2014;32(25):2821-2823
Musculoskeletal Pain in Patients With Chronic Myeloid Leukemia After Discontinuation of Imatinib: A Tyrosine Kinase Inhibitor Withdrawal Syndrome?
Richter J; Soderlund S; Lubking A; Dreimane A; Lotfi K; Markevarm B; Sjalander A; Saussele S; Olsson-Stromberg U; Stenke L
Review: DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS. 2011;5(3):202-212
First Global Consensus for Evidence-Based Management of the Hematopoietic Syndrome Resulting From Exposure to Ionizing Radiation
Dainiak N; Gent RN; Carr Z; Schneider R; Bader J; Buglova E; Chao N; Coleman CN; Ganser A; Gorin C; Hauer-Jensen M; Huff LA; Lillis-Hearne P; Maekawa K; Nemhauser J; Powles R; Schuenemann H; Shapiro A; Stenke L; Valverde N; Weinstock D; White D; Albanese J; Meineke V
Review: DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS. 2011;5(3):183-201
Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems.
Dainiak N; Gent RN; Carr Z; Schneider R; Bader J; Buglova E; Chao N; Coleman CN; Ganser A; Gorin C; Hauer-Jensen M; Huff LA; Lillis-Hearne P; Maekawa K; Nemhauser J; Powles R; Schünemann H; Shapiro A; Stenke L; Valverde N; Weinstock D; White D; Albanese J; Meineke V
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):134-135
The DNA glycosylase Myh1 is stabilized by cisplatin and inhibition of Myh1 expression increases cisplatin-induced apoptotic signaling in lung carcinoma cells
Viktorsson K; Efazat G; Haag P; Zong D; Stenke L; Sunnerhagen P; Lewensohn R
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):57
Cytotoxicity and cell death signaling in stem cell like AML cells
Haag P; Lindberg ML; Zong D; Kanter L; Lewensohn R; Stenke L; Viktorsson K
Letter: ANNALS OF HEMATOLOGY. 2009;88(2):173-175
Chronic myeloid leukemia presenting late in pregnancy. Report of a case and a questionnaire reflecting diversity in management options
Bjorkholm M; Ohm L; Stenke L
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2008;142(6):992-995
Clinical imatinib mesylate treatment induces early normalisation of aberrant neutrophil leukotriene C₄ synthase expression and activity in chronic myeloid leukaemia
Roos C; Stenke L; Ohm L; Widell S; Kumlin M; Lindgren JA; Tornhamre S
Letter: LEUKEMIA. 2006;20(11):2057-2060
A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib
Gruber FX; Hjorth-Hansen H; Mikkola I; Stenke L; Johansen T
Meeting abstract: BLOOD. 2005;106(11):222B
Gemtuzumab ozogamicin combined with hyper-CVAD in relapsed refractory CD33-positive acute lymphoblastic leukemia.
Stromberg O; Stenke L; Bernell P
Meeting abstract: BLOOD. 2005;106(11):566A
Quantitative analyses of BCR-ABL mutations associated with imatinib treatment in CML
Gruber F; Hansen HH; Olsen M; Eggen L; Skogen B; Gedde-Dahl T; Lundan T; Porkka K; Simonsson B; Markevdrn B; Wadenvik H; Stenke L
Review: LAKARTIDNINGEN. 2000;97(3):164-167
[Radioimmunotherapy is rapidly developing to clinically efficient therapy].
Stenke L; Lewensohn R; Carlsson J
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