Leif Stenke

Om mig
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Populärvetenskap och samverkan

Om mig

* specialist i invärtesmedicin och hematologi, docent vid KI. Han är
biträdande programdirektör för Socialstyrelsens Kunskapscentrum för
strålningsmedicin vid katastrofer (KcRN) som är en beredskapsfunktion
vid Centrum för strålningsmedicin.
* medlem i Socialstyrelsens medicinska expertgrupp för radiologiska och
nukleära händelser (RN-MeG). Han är också ledamot i Karolinska
Universitetssjukhusets strålskyddskommitté.

Forskningsbeskrivning

Stenkes forskning är inriktad mot studier av normal och förändrad blod-
och benmärgsfunktion vid sjukdomar och skador. Speciellt intresse riktas mot
myeloiska leukemier och inverkan av olika läkemedel och andra cellhämmande
agens, såsom joniserande strålning, på blodbildningen. Benmärgen,
kroppens ”blodfabrik”, är vårt känsligaste organ vad gäller effekt av
joniserande strålning. Om en människa utsätts för en hög stråldos är
överlevnadschansen därför vanligen beroende på omfattning och varaktighet
av det så kallade hematopoetiska syndromet, dvs graden av hämning av blod
och benmärg. Stenkes forskning syftar bl a till att förbättra kunskapen om
de cellulära och molekylära mekanismer som styr hur cellerna förökar sig
och hur de reparerar sina skador. Man studerar i detta sammanhang även
leukemiceller och hur de påverkas av olika typer av cellhämmande terapier.
Studierna är delvis av grundforskningskaraktär, med avsikten att t ex
molekylära upptäckter och fynd i samband med leukemibehandling i
förlängningen också kan leda till nya behandlingsmöjligheter för
benmärgsskadade patienter i samband med en strålningsolycka.

Artiklar

Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2025;114(2):334-342
Loss in Overall and Quality-Adjusted Life Expectancy for Patients With Chronic-Phase Chronic Myeloid Leukemia
Chen EY-T; Dahlen T; Stenke L; Bjorkholm M; Hao S; Dickman PW; Clements MS
Article: LEUKEMIA. 2024;38(4):781-787
Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial
Flygt H; Soederlund S; Richter J; Saussele S; Koskenvesa P; Stenke L; Mustjoki S; Dimitrijevic A; Stentoft J; Majeed W; Roy L; Wolf D; Dreimane A; Gjertsen BT; Gedde-Dahl T; Ahlstrand E; Markevaern B; Hjorth-Hansen H; Janssen J; Olsson-Stroemberg U
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2023;111(4):644-654
Despite warnings, co-medication with proton pump inhibitors and dasatinib is common in chronic myeloid leukemia, but XS004, a novel oral dasatinib formulation, provides reduced pH-dependence, minimizing undesirable drug-drug interactions
Larfors G; Andersson P; Jesson G; Liljebris C; Brisander M; Lennernas H; Stenke L
Article: BLOOD. 2023;142(1):73-89
Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
Dolinska M; Cai H; Mansson A; Shen J; Xiao P; Bouderlique T; Li X; Leonard E; Chang M; Gao Y; Medina JP; Kondo M; Sandhow L; Johansson A-SF; Deneberg S; Soederlund S; Jaedersten M; Ungerstedt J; Tobiasson M; Ostman A; Mustjoki S; Stenke L; Le Blanc K; Hellstroem-Lindberg E; Lehmann S; Ekblom M; Olsson-Stroemberg U; Sigvarosson M; Qian H
Article: ONCOIMMUNOLOGY. 2022;11(1):2109861
IFNγ directly counteracts imatinib-induced apoptosis of primary human CD34+CML stem/progenitor cells potentially through the upregulation of multiple key survival factors
Ujvari D; Malyukova A; Zovko A; Yektaei-Karin E; Madapura HS; Keszei M; Nagy N; Lotfi K; Bjorn N; Wallvik J; Stenke L; Salamon D
Article: BRITISH JOURNAL OF PHARMACOLOGY. 2022;179(19):4709-4721
The tyrosine kinase inhibitor nilotinib targets the discoidin domain receptor DDR2 in calcific aortic valve stenosis
Carracedo M; Pawelzik S-C; Artiach G; Pouwer MG; Plunde O; Saliba-Gustafsson P; Ehrenborg E; Eriksson P; Pieterman E; Stenke L; Princen HMG; Franco-Cereceda A; Back M
Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(17):e152585
IFN-a with dasatinib broadens the immune repertoire in patients with chronic-phase chronic myeloid leukemia
Huuhtanen J; Ilander M; Yadav B; Dufva OMJ; Lahteenmaki H; Kasanen T; Klievink J; Olsson-Stromberg U; Stentoft J; Richter J; Koskenvesa P; Hoglund M; Soderlund S; Dreimane A; Porkka K; Gedde-Dahl T; Gjertsen BT; Stenke L; Myhr-Eriksson K; Markevarn B; Lubking A; Dimitrijevic A; Udby L; Bjerrum OW; Hjorth-Hansen H; Mustjoki S
Article: CELL DEATH DISCOVERY. 2022;8(1):284
Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia
Haag P; Olsson M; Forsberg J; Lindberg ML; Stenerlow B; Zong D; Kanter L; Lewensohn R; Viktorsson K; Zhivotovsky B; Stenke L
Article: AMERICAN JOURNAL OF HEMATOLOGY. 2022;97(4):421-430
Adverse outcomes in chronic myeloid leukemia patients treated with tyrosine kinase inhibitors: Follow-up of patients diagnosed 2002-2017 in a complete coverage and nationwide agnostic register study
Dahlen T; Edgren G; Ljungman P; Flygt H; Richter J; Olsson-Stromberg U; Wadenvik H; Dreimane A; Myhr-Eriksson K; Zhao J; Sjalander A; Hoglund M; Stenke L
Article: JOURNAL OF RADIOLOGICAL PROTECTION. 2022;42(1):014004
The acute radiation syndrome-need for updated medical guidelines
Stenke L; Hedman C; Lindberg ML; Lindberg K; Valentin J
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2021;107(6):617-623
Long-term tolerability and efficacy after initial PegIFN-α addition to dasatinib in CML-CP: Five-year follow-up of the NordCML007 study
Flygt H; Soderlund S; Stentoft J; Richter J; Koskenvesa P; Mustjoki S; Majeed W; Lubking A; Dreimane A; Markevarn B; Stenke L; Myhr Eriksson K; Gjertsen BT; Gedde-Dahl T; Dimitrijevic A; Udby L; Olsson-Stromberg U; Hjorth-Hansen H
Article: CELL DEATH & DISEASE. 2021;12(10):875
Combination of tyrosine kinase inhibitors and the MCL1 inhibitor S63845 exerts synergistic antitumorigenic effects on CML cells
Malyukova A; Ujvari D; Yektaei-Karin E; Zovko A; Madapura HS; Keszei M; Nagy N; Lotfi K; Bjorn N; Wallvik J; Tamai M; Nguyen TTT; Akahane K; Inukai T; Stenke L; Salamon D
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2021;193(5):915-921
Successful tyrosine kinase inhibitor discontinuation outside clinical trials - data from the population-based Swedish chronic myeloid leukaemia registry
Flygt H; Sandin F; Dahlen T; Dremaine A; Lubking A; Markevarn B; Myhr-Eriksson K; Olsson K; Olsson-Stromberg U; Sjalander A; Soderlund S; Wennstrom L; Wadenvik H; Stenke L; Hoglund M; Richter J
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2020;29(1):151-156
Increased Risk of Chronic Myeloid Leukemia Following Gastric Conditions Indicating Helicobacter pylori Infection: A Case-Control Study
Larfors G; Richter J; Sjalander A; Stenke L; Hoglund M
Article: BONE MARROW TRANSPLANTATION. 2019;54(11):1764-1774
Allogeneic stem cell transplantation for chronic myeloid leukemia in the TKI era: population-based data from the Swedish CML registry
Lubking A; Dreimane A; Sandin F; Isaksson C; Markevarn B; Brune M; Ljungman P; Lenhoff S; Stenke L; Hoglund M; Richter J; Olsson-Stromberg U
Article: ONCOIMMUNOLOGY. 2019;8(9):e1638210
Immunological monitoring of newly diagnosed CML patients treated with bosutinib or imatinib first-line
Kreutzman A; Yadav B; Brummendorf TH; Gjertsen BT; Hee ML; Janssen J; Kasanen T; Koskenvesa P; Lofti K; Markevarn B; Olsson-Stromberg U; Stentoft J; Stenke L; Soderlund S; Udby L; Richter J; Hjorth-Hansen H; Mustjoki S
Article: APPLIED HEALTH ECONOMICS AND HEALTH POLICY. 2019;17(4):555-567
Cost Effectiveness of the Third-Generation Tyrosine Kinase Inhibitor (TKI) Ponatinib, vs. Second-Generation TKIs or Stem Cell Transplant, as Third-Line Treatment for Chronic-Phase Chronic Myeloid Leukemia
Hirt C; Iannazzo S; Chiroli S; McGarry LJ; le Coutre P; Stenke L; Dahlen T; Lipton JH
Article: ONCOLOGY REPORTS. 2018;40(2):902-908
Montelukast, a cysteinyl leukotriene receptor antagonist, inhibits the growth of chronic myeloid leukemia cells through apoptosis
Zovko A; Yektaei-Karin E; Salamon D; Nilsson A; Wallvik J; Stenke L
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;498(3):502-508
Interferon γ is a strong, STAT1-dependent direct inducer of BCL6 expression in multiple myeloma cells
Ujvari D; Nagy N; Madapura HS; Kallas T; Krohnke MCL; Stenke L; Klein E; Salamon D
Article: LAKARTIDNINGEN. 2017;114:ER3M
[Chronic myeloid leukemia – a model disease for targeted therapy].
Richter J; Stenke L
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Corrigendum: LEUKEMIA. 2024;38(4):925
Correction: Treatment-free remission after a second TKI discontinuation attempt in patients with Chronic Myeloid Leukemia re-treated with dasatinib - interim results from the DAstop2 trial.
Flygt H; Söderlund S; Richter J; Saussele S; Koskenvesa P; Stenke L; Mustjoki S; Dimitrijevic A; Stentoft J; Majeed W; Roy L; Wolf D; Dreimane A; Gjertsen BT; Gedde-Dahl T; Ahlstrand E; Markevärn B; Hjorth-Hansen H; Janssen J; Olsson-Strömberg U
Letter: LEUKEMIA. 2023;37(5):1156-1159
The impact of Covid-19 in patients with chronic myeloid leukemia-a nationwide population-based study
Dahlen T; Flygt H; Lubking A; Olsson-Stromberg U; Wennstrom L; Dreimane A; Sjalander A; Leach S; Gisslen M; Li H; Hoglund M; Stenke L; Nyberg F
Editorial: JOURNAL OF RADIOLOGICAL PROTECTION. 2022;42(3):030202
To be (prepared) or not to be-that is hardly the question
Valentin J; Stenke L
Review: JOURNAL OF RADIOLOGICAL PROTECTION. 2022;42(3):031001
Mental health and psychosocial consequences linked to radiation emergencies-increasingly recognised concerns
Lagergren Lindberg M; Hedman C; Lindberg K; Valentin J; Stenke L
Letter: LEUKEMIA. 2021;35(8):2416-2418
Molecular status 36 months after TKI discontinuation in CML is highly predictive for subsequent loss of MMR-final report from AFTER-SKI
Richter J; Lubking A; Soderlund S; Lotfi K; Markevarn B; Sjalander A; Stenke L; Deneberg S; Ahlstrand E; Myhr-Eriksson K; Panayiotidis P; Gedde-Dahl T; Zackova D; Mayer J; Olsson-Stromberg U; Mahon F-X; Saussele S; Hjorth-Hansen H; Koskenvesa P
Editorial: JACC: CARDIOONCOLOGY. 2020;2(1):123-126
Aortic Stenosis and the Tyrosine Kinase Inhibitor Nilotinib in Chronic Myeloid Leukemia
Carracedo M; Stenke L; Franco-Cereceda A; Back M
Published conference paper: RADIATION PROTECTION DOSIMETRY. 2018;182(1):80-84
COORDINATION OF MANAGEMENT OF THE ACUTE RADIATION SYNDROME
Stenke L; Lindberg K; Lindberg ML; Lewensohn R; Valentin J; Powles R; Dainiak N
Letter: LEUKEMIA. 2017;31(8):1825-1827
No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: a population-based study in Sweden
Gunnarsson N; Hoglund M; Stenke L; Sandin F; Bjorkholm M; Dreimane A; Lambe M; Markevarn B; Olsson-Stromberg U; Wadenvik H; Richter J; Sjalander A
Published conference paper: RADIATION PROTECTION DOSIMETRY. 2016;171(1):134-138
Lessons Learnt from the Fukushima Accident-A Swedish Medical Preparedness Perspective
Stenke L; von Schreeb J; Simonsson M; Johansson J; Postgard P; Sigurdsson S; Ljungquist A; Lindberg ML
Published conference paper: RADIATION PROTECTION DOSIMETRY. 2016;171(1):144-155
Using the Grade Approach to Support the Development of Recommendations for Public Health Interventions in Radiation Emergencies
Carr Z; Clarke M; Akl EA; Schneider R; Murith C; Li C; Parrish-Sprowl J; Stenke L; Cui-Ping L; Bertrand S; Miller C
Letter: JOURNAL OF CLINICAL ONCOLOGY. 2014;32(25):2821-2823
Musculoskeletal Pain in Patients With Chronic Myeloid Leukemia After Discontinuation of Imatinib: A Tyrosine Kinase Inhibitor Withdrawal Syndrome?
Richter J; Soderlund S; Lubking A; Dreimane A; Lotfi K; Markevarm B; Sjalander A; Saussele S; Olsson-Stromberg U; Stenke L
Review: DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS. 2011;5(3):202-212
First Global Consensus for Evidence-Based Management of the Hematopoietic Syndrome Resulting From Exposure to Ionizing Radiation
Dainiak N; Gent RN; Carr Z; Schneider R; Bader J; Buglova E; Chao N; Coleman CN; Ganser A; Gorin C; Hauer-Jensen M; Huff LA; Lillis-Hearne P; Maekawa K; Nemhauser J; Powles R; Schuenemann H; Shapiro A; Stenke L; Valverde N; Weinstock D; White D; Albanese J; Meineke V
Review: DISASTER MEDICINE AND PUBLIC HEALTH PREPAREDNESS. 2011;5(3):183-201
Literature review and global consensus on management of acute radiation syndrome affecting nonhematopoietic organ systems.
Dainiak N; Gent RN; Carr Z; Schneider R; Bader J; Buglova E; Chao N; Coleman CN; Ganser A; Gorin C; Hauer-Jensen M; Huff LA; Lillis-Hearne P; Maekawa K; Nemhauser J; Powles R; Schünemann H; Shapiro A; Stenke L; Valverde N; Weinstock D; White D; Albanese J; Meineke V
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):134-135
The DNA glycosylase Myh1 is stabilized by cisplatin and inhibition of Myh1 expression increases cisplatin-induced apoptotic signaling in lung carcinoma cells
Viktorsson K; Efazat G; Haag P; Zong D; Stenke L; Sunnerhagen P; Lewensohn R
Meeting abstract: EUROPEAN JOURNAL OF CANCER, SUPPLEMENT. 2010;8(5):57
Cytotoxicity and cell death signaling in stem cell like AML cells
Haag P; Lindberg ML; Zong D; Kanter L; Lewensohn R; Stenke L; Viktorsson K
Letter: ANNALS OF HEMATOLOGY. 2009;88(2):173-175
Chronic myeloid leukemia presenting late in pregnancy. Report of a case and a questionnaire reflecting diversity in management options
Bjorkholm M; Ohm L; Stenke L
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2008;142(6):992-995
Clinical imatinib mesylate treatment induces early normalisation of aberrant neutrophil leukotriene C₄ synthase expression and activity in chronic myeloid leukaemia
Roos C; Stenke L; Ohm L; Widell S; Kumlin M; Lindgren JA; Tornhamre S
Letter: LEUKEMIA. 2006;20(11):2057-2060
A novel Bcr-Abl splice isoform is associated with the L248V mutation in CML patients with acquired resistance to imatinib
Gruber FX; Hjorth-Hansen H; Mikkola I; Stenke L; Johansen T
Meeting abstract: BLOOD. 2005;106(11):222B
Gemtuzumab ozogamicin combined with hyper-CVAD in relapsed refractory CD33-positive acute lymphoblastic leukemia.
Stromberg O; Stenke L; Bernell P
Meeting abstract: BLOOD. 2005;106(11):566A
Quantitative analyses of BCR-ABL mutations associated with imatinib treatment in CML
Gruber F; Hansen HH; Olsen M; Eggen L; Skogen B; Gedde-Dahl T; Lundan T; Porkka K; Simonsson B; Markevdrn B; Wadenvik H; Stenke L
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