Lars Tjernberg

Lars Tjernberg

Lektor/Funktionsenhetschef | Docent
Telefon: +46852483408
Besöksadress: BioClinicum J9:20, Visionsgatan 4, 17164 Huddinge
Postadress: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Tjernberg, 171 77 Stockholm

Om mig

  • Group leader at NVS. Research on Alzheimer disease using cutting edge
    techniques including mass spectrometry and nanoscopy.
    I have dedicated my 24 years in scientific research to understand how the
    amyloid β-peptide (Aβ) is formed and how it polymerizes into fibrils, and
    how these processes can be studied and targeted. I have expertise in
    analytical chemistry with focus on chromatography and spectrometry and long
    track record as a project and group leader at Karolinska Institutet. Under my
    leadership, we have had a long-lasting industrial collaboration with a
    Japanese pharmaceutical company, resulting in several patent applications on
    Aβ related discoveries. Importantly, I have shown the motif most critical
    for Aβ polymerization (residues 16-20 in Aβ, also called the Tjernberg
    peptide), and that ligands binding to this motif can inhibit Aβ
    polymerization. Furthermore, I have developed strategies for single plaque
    core analysis, proteomics of selected cells, and studying Aβ polymerization
    at nanomolar concentrations. I use several different systems including in
    vitro, cell lines, primary neurons, mouse as well as human brain. I have been
    in the forefront of introducing and setting up new technology at the
    department, including nanoscale liquid chromatography, isotope-labeling
    proteomics, laser capture microdissection and proximity ligation interacting
    studies in neurons. More recently, my group have developed expertise in
    super-resolution microscopy and reported on the synaptic localization of the
    Aβ producing enzyme γ-secretase.


Alla övriga publikationer


  • Lektor/Funktionsenhetschef, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2018-

Examina och utbildning

  • Docent, Neurobiologi, Karolinska Institutet, 2008

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