Lars Tjernberg
Lektor/Funktionsenhetschef | Docent
E-postadress: lars.tjernberg@ki.se
Telefon: +46852483408
Besöksadress: BioClinicum J9:20, Visionsgatan 4, 17164 Huddinge
Postadress: H1 Neurobiologi, vårdvetenskap och samhälle, H1 Neurogeriatrik Tjernberg, 171 77 Stockholm
Om mig
- Group leader at NVS. Research on Alzheimer disease using cutting edge
techniques including mass spectrometry and nanoscopy.
I have dedicated my 24 years in scientific research to understand how the
amyloid β-peptide (Aβ) is formed and how it polymerizes into fibrils, and
how these processes can be studied and targeted. I have expertise in
analytical chemistry with focus on chromatography and spectrometry and long
track record as a project and group leader at Karolinska Institutet. Under my
leadership, we have had a long-lasting industrial collaboration with a
Japanese pharmaceutical company, resulting in several patent applications on
Aβ related discoveries. Importantly, I have shown the motif most critical
for Aβ polymerization (residues 16-20 in Aβ, also called the Tjernberg
peptide), and that ligands binding to this motif can inhibit Aβ
polymerization. Furthermore, I have developed strategies for single plaque
core analysis, proteomics of selected cells, and studying Aβ polymerization
at nanomolar concentrations. I use several different systems including in
vitro, cell lines, primary neurons, mouse as well as human brain. I have been
in the forefront of introducing and setting up new technology at the
department, including nanoscale liquid chromatography, isotope-labeling
proteomics, laser capture microdissection and proximity ligation interacting
studies in neurons. More recently, my group have developed expertise in
super-resolution microscopy and reported on the synaptic localization of the
Aβ producing enzyme γ-secretase.
Artiklar
- Article: EBIOMEDICINE. 2025;113:105598Zhou RZ; Gaunitz S; Kirsebom B-E; Lundin B; Hellstroem M; Jejcic A; Skoeldunger A; Wimo A; Winblad B; Fladby T; Schedin-Weiss S; Tjernberg LO
- Article: ALZHEIMERS & DEMENTIA. 2025;21(3):e70091Gao Y; Wang L; Doeswijk T; Winblad B; Schedin-Weiss S; Tjernberg LO
- Article: BRAIN COMMUNICATIONS. 2024;6(6):fcae371Zhou RZ; Duell F; Axenhus M; Joensson L; Winblad B; Tjernberg LO; Schedin-Weiss S
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2024;100(s1):S93-S101Arulf SE; Zhou RZ; Kirsebom B-E; Jejcic A; Fladby T; Winblad B; Tjernberg L; Schedin-Weiss S
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(7):3622Axenhus M; Doeswijk T; Nilsson P; Matton A; Winblad B; Tjernberg L; Schedin-Weiss S
- Article: BMC PUBLIC HEALTH. 2024;24(1):823Axenhus M; Schedin-Weiss S; Tjernberg L; Winblad B
- Article: ALZHEIMERS & DEMENTIA. 2023;19(7):3244-3249Zhou RZ; Vetrano DL; Grande G; Duell F; Jonsson L; Laukka EJ; Fredolini C; Winblad B; Tjernberg L; Schedin-Weiss S
- Article: ALZHEIMERS RESEARCH & THERAPY. 2022;14(1):196Sandberg A; Berenjeno-Correa E; Rodriguez RC; Axenhus M; Weiss SS; Batenburg K; Hoozemans JJM; Tjernberg LO; Scheper W
- Article: GLYCOBIOLOGY. 2022;32(6):506-517Lin T; van Husen LS; Yu Y; Tjernberg LO; Schedin-Weiss S
- Article: BMC GERIATRICS. 2022;22(1):365Axenhus M; Schedin-Weiss S; Tjernberg L; Wimo A; Eriksdotter M; Bucht G; Winblad B
- Article: SCIENTIFIC DATA. 2021;8(1):312Haytural H; Benfeitas R; Schedin-Weiss S; Bereczki E; Rezeli M; Unwin RD; Wang X; Dammer EB; Johnson ECB; Seyfried NT; Winblad B; Tijms BM; Visser PJ; Frykman S; Tjernberg LO
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2021;13:735334Sandebring-Matton A; Axenhus M; Bogdanovic N; Winblad B; Schedin-Weiss S; Nilsson P; Tjernberg LO
- Article: CHEMBIOCHEM. 2021;22(22):3208-3213van Husen LS; Katsori A-M; Meineke B; Tjernberg LO; Schedin-Weiss S; Elsasser SJ
- Article: JOURNAL OF NEUROCHEMISTRY. 2021;159(2):292-304Gaunitz S; Tjernberg LO; Schedin-Weiss S
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2021;83(2):833-852Yu Y; Gao Y; Winblad B; Tjernberg L; Weiss SS
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2021;22(9):4530Gao Y; Wennmalm S; Winblad B; Schedin-Weiss S; Tjernberg LO
- Article: BRAIN COMMUNICATIONS. 2021;3(2):fcab079Haytural H; Jorda-Siquier T; Winblad B; Mulle C; Tjernberg LO; Granholm A-C; Frykman S; Barthet G
- Article: CURRENT ALZHEIMER RESEARCH. 2021;17(9):858-867Axenhus M; Winblad B; Tjernberg LO; Schedin-Weiss S
- Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2020;1867(9):118737Hromadkova L; Bezdekova D; Pala J; Schedin-Weiss S; Tjernberg LO; Hoschl C; Ovsepian SV
- Article: FEBS JOURNAL. 2020;287(15):3221-3234Schedin-Weiss S; Gaunitz S; Sui P; Chen Q; Haslam SM; Blennow K; Winblad B; Dell A; Tjernberg LO
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;75(1):321-335Schedin-Weiss S; Nilsson P; Sandebring-Matton A; Axenhus M; Sekiguchi M; Saito T; Winblad B; Saido T; Tjernberg LO
- Article: BMC NEUROSCIENCE. 2020;21(1):6Lundgren JL; Vandermeulen L; Sandebring-Matton A; Ahmed S; Winblad B; Di Luca M; Tjernberg LO; Marcello E; Frykman S
- Article: MOLECULAR & CELLULAR PROTEOMICS. 2020;19(1):128-141Haytural H; Mermelekas G; Emre C; Nigam SM; Carroll SL; Winblad B; Bogdanovic N; Barthet G; Granholm A-C; Orre LM; Tjernberg LO; Frykman S
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;72(2):537-548van Husen LS; Schedin-Weiss S; Minh NT; Kazmi MA; Winblad B; Sakmar TP; Elsaesser SJ; Tjernberg LO
- Article: JOURNAL OF ALZHEIMERS DISEASE. 2019;71(4):1163-1174Hashimoto M; Yamazaki A; Ohno A; Kimura T; Winblad B; Tjernberg LO
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2019;11:273Haytural H; Lundgren JL; Kose TB; Jorda-Siquier T; Kalcheva M; Ahmed MS; Winblad B; Sundstrom E; Barthet G; Tjernberg LO; Frykman S
- Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2019;95:86-95Martinsson I; Capetillo-Zarate E; Faideau M; Willen K; Esteras N; Frykman S; Tjernberg LO; Gouras GK
- Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2019;23(3):2103-2114Bonito-Oliva A; Schedin-Weiss S; Younesi SS; Tiiman A; Adura C; Paknejad N; Brendel M; Romin Y; Parchem RJ; Graff C; Vukojevic V; Tjernberg LO; Terenius L; Winblad B; Sakmar TP; Graham WV
- Article: EXPERIMENTAL CELL RESEARCH. 2018;371(1):175-184Eriksdotter M; Navarro-Oviedo M; Mitra S; Wahlberg L; Linderoth B; Tjernberg LO; Behbahani H
- Article: LIFE SCIENCE ALLIANCE. 2018;1(3):e201800028Yu Y; Jans DC; Winblad B; Tjernberg LO; Schedin-Weiss S
- Article: PROTEIN SCIENCE. 2017;26(11):2312-2318Rising A; Cederlund E; Palmberg C; Uhlhorn H; Gaunitz S; Nordling K; Agren E; Ihse E; Westermark GT; Tjernberg L; Jornvall H; Johansson J; Westermark P
- Article: ALZHEIMERS RESEARCH & THERAPY. 2017;9(1):57Schedin-Weiss S; Inoue M; Hromadkova L; Teranishi Y; Yamamoto NG; Wiehager B; Bogdanovic N; Winblad B; Sandebring-Matton A; Frykman S; Tjernberg LO
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;483(1):352-358Frykman S; Inoue M; Ikeda A; Teranishi Y; Kihara T; Lundgren JL; Yamamoto NG; Bogdanovic N; Winblad B; Schedin-Weiss S; Tjernberg LO
- Article: LANCET NEUROLOGY. 2016;15(5):455-532Winblad B; Amouyel P; Andrieu S; Ballard C; Brayne C; Brodaty H; Cedazo-Minguez A; Dubois B; Edvardsson D; Feldman H; Fratiglioni L; Frisoni GB; Gauthier S; Georges J; Graff C; Iqbal K; Jessen F; Johansson G; Jonsson L; Kivipelto M; Knapp M; Mangialasche F; Melis R; Nordberg A; Rikkert MO; Qiu C; Sakmar TP; Scheltens P; Schneider LS; Sperling R; Tjernberg LO; Waldemar G; Wimo A; Zetterberg H
- Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2016;4:29Schedin-Weiss S; Caesar I; Winblad B; Blom H; Tjernberg LO
- Article: ANALYTICAL CHEMISTRY. 2015;87(23):11700-11705Wennmalm S; Chmyrov V; Widengren J; Tjernberg L
- Article: MOLECULAR NEUROBIOLOGY. 2015;52(3):1077-1092Lucotte B; Tajhizi M; Alkhatib D; Samuelsson E-B; Wiehager B; Schedin-Weiss S; Sundstrom E; Winblad B; Tjernberg LO; Behbahani H
- Article: JOURNAL OF NEUROCHEMISTRY. 2015;135(3):606-615Lundgren JL; Ahmed S; Schedin-Weiss S; Gouras GK; Winblad B; Tjernberg LO; Frykman S
- Article: PROTEOMICS. 2015;15(19):3349-3355Nilsson P; Loganathan K; Sekiguchi M; Winblad B; Iwata N; Saido TC; Tjernberg LO
- Article: FEBS JOURNAL. 2015;282(17):3438-3451Teranishi Y; Inoue M; Yamamoto NG; Kihara T; Wiehager B; Ishikawa T; Winblad B; Schedin-Weiss S; Frykman S; Tjernberg LO
- Article: FEBS JOURNAL. 2015;282(14):2587-2599Inoue M; Hur J-Y; Kihara T; Teranishi Y; Yamamoto NG; Ishikawa T; Wiehager B; Winblad B; Tjernberg LO; Schedin-Weiss S
- Article: NEUROSCIENCE LETTERS. 2014;566:125-130Lundgren JL; Ahmed S; Winblad B; Gouras GK; Tjernberg LO; Frykman S
- Article: FEBS OPEN BIO. 2014;4:393-406Wanngren J; Lara P; Ojemalm K; Maioli S; Moradi N; Chen L; Tjernberg LO; Lundkvist J; Nilsson I; Karlstrom H
- Article: PLOS ONE. 2013;8(5):e63962Schedin-Weiss S; Inoue M; Teranishi Y; Yamamoto NG; Karlstrom H; Winblad B; Tjernberg LO
- Article: PLOS ONE. 2013;8(2):e55847Sandebring A; Welander H; Winblad B; Graff C; Tjernberg LO
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2012;424(3):476-481Teranishi Y; Hur J-Y; Gu GJ; Kihara T; Ishikawa T; Nishimura T; Winblad B; Behbahani H; Kamali-Moghaddam M; Frykman S; Tjernberg LO
- Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2012;16(8):1686-1700Hashimoto M; Bogdanovic N; Nakagawa H; Volkmann I; Aoki M; Winblad B; Sakai J; Tjernberg LO
- Article: NEUROCHEMISTRY INTERNATIONAL. 2012;61(1):108-118Frykman S; Teranishi Y; Hur J-Y; Sandebring A; Yamamoto NG; Ankarcrona M; Nishimura T; Winblad B; Bogdanovic N; Schedin-Weiss S; Kihara T; Tjernberg LO
- Article: NEUROBIOLOGY OF AGING. 2012;33(5):1010.e1-1010.e13Philipson O; Lord A; Lalowski M; Soliymani R; Baumann M; Thyberg J; Bogdanovic N; Olofsson T; Tjernberg LO; Ingelsson M; Lannfelt L; Kalimo H; Nilsson LNG
- Article: JOURNAL OF NEUROSCIENCE METHODS. 2012;205(2):364-367Hashimoto M; Aoki M; Winblad B; Tjernberg LO
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(15):11991-12005Hur J-Y; Teranishi Y; Kihara T; Yamamoto NG; Inoue M; Hosia W; Hashimoto M; Winblad B; Frykman S; Tjernberg LO
- Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2011;15(10):2150-2163γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ42/Aβ40 ratioHedskog L; Petersen CAH; Svensson AI; Welander H; Tjernberg LO; Karlstrom H; Ankarcrona M
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(36):31153-31158Pamren A; Wanngren J; Tjernberg LO; Winblad B; Bhat R; Naslund J; Karlstrom H
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2010;18(11):1202-1208Keller L; Welander H; Chiang H-H; Tjernberg LO; Nennesmo I; Wallin AK; Graff C
- Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2010;14(11):2675-2686Teranishi Y; Hur J-Y; Welander H; Franberg J; Aoki M; Winblad B; Frykman S; Tjernberg LO
- Article: ACTA NEUROPATHOLOGICA. 2010;119(5):543-554Hashimoto M; Bogdanovic N; Volkmann I; Aoki M; Winblad B; Tjernberg LO
- Article: PLOS ONE. 2010;5(3):e9772Franberg J; Karlstrom H; Winblad B; Tjernberg LO; Frykman S
- Article: PLOS ONE. 2010;5(1):e8948Frykman S; Hur J-Y; Franberg J; Aoki M; Winblad B; Nahalkova J; Behbahani H; Tjernberg LO
- Article: NEUROCHEMISTRY INTERNATIONAL. 2010;56(1):67-76Nahalkova J; Volkmann I; Aoki M; Winblad B; Bogdanovic N; Tjernberg LO; Behbahani H
- Article: JOURNAL OF NEUROCHEMISTRY. 2009;110(2):697-706Welander H; Franberg J; Graff C; Sundstrom E; Winblad B; Tjernberg LO
- Article: NEUROREPORT. 2008;19(11):1085-1089Aoki M; Volkmann I; Tjernberg LO; Winblad B; Bogdanovic N
- Article: FEBS JOURNAL. 2008;275(6):1174-1187Hur J-Y; Welander H; Behbahani H; Aoki M; Franberg J; Winblad B; Frykman S; Tjernberg LO
- Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;361(4):822-828Larsson A; Soderberg L; Westermark GT; Sletten K; Engstrom U; Tjernberg LO; Naslund J; Westermark P
- Article: BIOCHEMISTRY. 2007;46(25):7647-7654Franberg J; Welander H; Aoki M; Winblad B; Tjernberg LO; Frykman S
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(39):29096-29104Falkevall A; Alikhani N; Bhushan S; Pavlov PF; Busch K; Johnson KA; Eneqvist T; Tjernberg L; Ankarcrona M; Glaser E
- Article: BIOCHEMISTRY. 2006;45(32):9849-9856Soderberg L; Bogdanovic N; Axelsson B; Winblad B; Naslund J; Tjernberg LO
- Article: BIOCHEMISTRY. 2005;44(47):15602-15609Kakuyama H; Söderberg L; Horigome K; Winblad B; Dahlqvist C; Näslund J; Tjernberg LO
- Article: JOURNAL OF CELL BIOLOGY. 2005;171(1):87-98Yu WH; Cuervo AM; Kumar A; Peterhoff CM; Schmidt SD; Lee JH; Mohan PS; Mercken M; Farmery MR; Tjernberg LO; Jiang Y; Duff K; Uchiyama Y; Nälund J; Mathews PM; Cataldo AM; Nixon RA
- Article: FEBS JOURNAL. 2005;272(9):2231-2236Söderberg L; Dahlqvist C; Kakuyama H; Thyberg J; Ito A; Winblad B; Näslund J; Tjernberg LO
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(2):1007-1015Söderberg L; Kakuyama H; Möller A; Ito A; Winblad B; Tjernberg LO; Näslund J
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(49):51654-51660Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Pursglove SE; Ito A; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
- Article: BIOCHEMISTRY. 2004;43(16):4655-4661Hosia W; Bark N; Liepinsh E; Tjernberg A; Persson B; Hallén D; Thyberg J; Johansson J; Tjernberg L
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(27):24277-24284Farmery MR; Tjernberg LO; Pursglove SE; Bergman A; Winblad B; Näslund J
- Article: NEUROSCIENCE LETTERS. 2003;337(2):111-113Lilius L; Forsell C; Axelman K; Winblad B; Graff C; Tjernberg L
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(45):43243-43246Tjernberg L; Hosia W; Bark N; Thyberg J; Johansson J
- Article: BIOCHEMICAL JOURNAL. 2002;366(Pt 1):343-351Tjernberg LO; Tjernberg A; Bark N; Shi Y; Ruzsicska BP; Bu ZM; Thyberg J; Callaway DJE
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(3):1673-1678Kuner P; Bohrmann B; Tjernberg LO; Näslund J; Huber G; Celenk S; Grüninger-Leitch F; Richards JG; Jakob-Roetne R; Kemp JA; Nordstedt C
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(15):8669-8674Häggqvist B; Näslund J; Sletten K; Westermark GT; Mucchiano G; Tjernberg LO; Nordstedt C; Engström U; Westermark P
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(23):15990-15995Bohrmann B; Tjernberg L; Kuner P; Poli S; Levet-Trafit B; Näslund J; Richards G; Huber W; Döbeli H; Nordstedt C
- Article: FEBS LETTERS. 1999;451(3):238-242Oppermann UCT; Salim S; Tjernberg LO; Terenius L; Jörnvall H
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(18):12619-12625Tjernberg LO; Callaway DJE; Tjernberg A; Hahne S; Lilliehöök C; Terenius L; Thyberg J; Nordstedt C
- Article: CHEMISTRY AND BIOLOGY. 1999;6(1):53-62Tjernberg LO; Pramanik A; Björling S; Thyberg P; Thyberg J; Nordstedt C; Berndt KD; Terenius L; Rigler R
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(19):12601-12605Tjernberg LO; Lilliehook C; Callaway DJE; Naslund J; Hahne S; Thyberg J; Terenius L; Nordstedt C
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(3):1870-1875Tjernberg LO; Naslund J; Thyberg J; Gandy SE; Terenius L; Nordstedt C
- Article: JOURNAL OF NEUROCHEMISTRY. 1996;67(1):294-301Naslund J; Karlstrom AR; Tjernberg LO; Schierhorn A; Terenius L; Nordstedt C
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(15):8545-8548Tjernberg LO; Naslund J; Lindqvist F; Johansson J; Karlstrom AR; Thyberg J; Terenius L; Nordstedt C
- Article: NEURON. 1995;15(1):219-228NASLUND J; THYBERG J; TJERNBERG LO; WERNSTEDT C; KARLSTROM AR; BOGDANOVIC N; GANDY SE; LANNFELT L; TERENIUS L; NORDSTEDT C
- Article: LAKARTIDNINGEN. 1995;92(18):1899-1900Nordstedt C; Näslund J; Tjernberg LO; Terenius L
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Alla övriga publikationer
- Review: ALZHEIMERS & DEMENTIA. 2025;21(3):e70048Wang L; Sooram B; Kumar R; Schedin-Weiss S; Tjernberg LO; Winblad B
- Review: BIOMEDICINES. 2021;9(7):801Lin T; Tjernberg LO; Schedin-Weiss S
- Review: BIOMOLECULES. 2021;11(6):858Gaunitz S; Tjernberg LO; Schedin-Weiss S
- Review: JOURNAL OF INTERNAL MEDICINE. 2016;280(2):153-163Tjernberg LO; Rising A; Johansson J; Jaudzems K; Westermark P
- Review: FEBS JOURNAL. 2014;281(1):46-62Schedin-Weiss S; Winblad B; Tjernberg LO
- Review: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2010;14(4):741-757Nilsson P; Iwata N; Muramatsu S-I; Tjernberg LO; Winblad B; Saido TC
- Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s549Hansson CA; Frykman S; Farmery MR; Tjernberg LO; Nilsberth C; Winblad B; Cowburn RF; Thyberg J; Ankarcrona M
- Meeting abstract: NEUROBIOLOGY OF AGING. 2004;25:s148Tjernberg LO; Bogdanovic N; Axelsson B; Winblad B; Näslund J
- Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2004;61(3):326-335Johansson J; Weaver TE; Tjernberg LO
- Doctoral thesis: 1997Tjernberg L
- Review: LAKARTIDNINGEN. 1995;92(42):3881-3884Nordstedt C; Näslund J; Tjernberg LO; Karlström A
Anställningar
- Lektor/Funktionsenhetschef, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2018-
Examina och utbildning
- Docent, Neurobiologi, Karolinska Institutet, 2008