Lars Muhl

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: CIRCULATION RESEARCH. 2024;134(11):1405-1423

Single-Cell Gene-Regulatory Networks of Advanced Symptomatic Atherosclerosis

Mocci G; Sukhavasi K; Ord T; Bankier S; Singha P; Arasu UT; Agbabiaje OO; Makinen P; Ma L; Hodonsky CJ; Aherrahrou R; Muhl L; Liu J; Gustafsson S; Byandelger B; Wang Y; Koplev S; Lendahl U; Owens GK; Leeper NJ; Pasterkamp G; Vanlandewijck M; Michoel T; Ruusalepp A; Hao K; Yla-Herttuala S; Vali M; Jarve H; Mokry M; Civelek M; Miller CJ; Kovacic JC; Kaikkonen MU; Betsholtz C; Bjorkegren JLM
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2024;25(8):4320

Renal Endothelial Single-Cell Transcriptomics Reveals Spatiotemporal Regulation and Divergent Roles of Differential Gene Transcription and Alternative Splicing in Murine Diabetic Nephropathy

Zhou A-X; Jeansson M; He L; Wigge L; Tonelius P; Tati R; Cederblad L; Muhl L; Uhrbom M; Liu J; Granqvist AB; Lerman LO; Betsholtz C; Hansen PBL
Article: NEURON. 2023;111(23):3745-3764.e7

Molecular anatomy of adult mouse leptomeninges

Pietila R; Del Gaudio F; He L; Vazquez-Liebanas E; Vanlandewijck M; Muhl L; Mocci G; Bjornholm KD; Lindblad C; Fletcher-Sandersjoo A; Svensson M; Thelin EP; Liu J; van Voorden AJ; Torres M; Antila S; Xin L; Karlstrom H; Storm-Mathisen J; Bergersen LH; Moggio A; Hansson EM; Ulvmar MH; Nilsson P; Makinen T; Mae MA; Alitalo K; Proulx ST; Engelhardt B; McDonald DM; Lendahl U; Andrae J; Betsholtz C
Article: NAT CARDIOVASC RES. 2023;2(6):530-549

Incongruence between transcriptional and vascular pathophysiological cell states

Fernandez-Chacon M; Muhleder S; Regano A; Garcia-Ortega L; Rocha SF; Torroja C; Sanchez-Munoz MS; Lytvyn M; Casquero-Garcia V; De Andres-Laguillo M; Muhl L; Orlich MM; Gaengel K; Camafeita E; Vazquez J; Benguria A; Iruela-Arispe ML; Dopazo A; Sanchez-Cabo F; Carter H; Benedito R
Article: DEVELOPMENTAL CELL. 2022;57(20):2426-2443.e6

A single-cell transcriptomic inventory of murine smooth muscle cells

Muhl L; Mocci G; Pietila R; Liu J; He L; Genove G; Leptidis S; Gustafsson S; Buyandelger B; Raschperger E; Hansson EM; Bjorkegren JLM; Vanlandewijck M; Lendahl U; Betsholtz C
Article: STEM CELL REPORTS. 2022;17(5):1089-1104

The SARS-CoV-2 receptor ACE2 is expressed in mouse pericytes but not endothelial cells: Implications for COVID-19 vascular research

Muhl L; He L; Sun Y; Mae MA; Pietila R; Liu J; Genove G; Zhang L; Xie Y; Leptidis S; Mocci G; Stritt S; Osman A; Anisimov A; Hemanthakumar KA; Rasanen M; Hansson EM; Bjorkegren J; Vanlandewijck M; Blomgren K; Makinen T; Peng X-R; Hu Y; Ernfors P; Arnold TD; Alitalo K; Lendahl U; Betsholtz C
Article: EXPERIMENTAL CELL RESEARCH. 2021;402(2):112576

A human cell type similar to murine central nervous system perivascular fibroblasts

Liu J; He L; Muhl L; Mocci G; Gustavsson S; Buyandelger B; Vanlandewijck M; Betsholtz C; Westermark B; Andrae J
Article: SCIENTIFIC REPORTS. 2020;10(1):22383

Blocking PDGF-CC signaling ameliorates multiple sclerosis-like neuroinflammation by inhibiting disruption of the blood-brain barrier

Zeitelhofer M; Adzemovic MZ; Moessinger C; Stefanitsch C; Strell C; Muhl L; Brundin L; Fredriksson L; Olsson T; Eriksson U; Nilsson I
Article: NATURE COMMUNICATIONS. 2020;11(1):3953

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination

Muhl L; Genove G; Leptidis S; Liu J; He L; Mocci G; Sun Y; Gustafsson S; Buyandelger B; Chivukula IV; Segerstolpe A; Raschperger E; Hansson EM; Bjorkegren JLM; Peng X-R; Vanlandewijck M; Lendahl U; Betsholtz C
Article: EMBO REPORTS. 2020;21(7):e49343

VEGF-B signaling impairs endothelial glucose transcytosis by decreasing membrane cholesterol content

Moessinger C; Nilsson I; Muhl L; Zeitelhofer M; Heller Sahlgren B; Skogsberg J; Eriksson U
Article: NATURE COMMUNICATIONS. 2020;11(1):2724

Specific fibroblast subpopulations and neuronal structures provide local sources of Vegfc-processing components during zebrafish lymphangiogenesis

Wang G; Muhl L; Padberg Y; Dupont L; Peterson-Maduro J; Stehling M; le Noble F; Colige A; Betsholtz C; Schulte-Merker S; van Impel A
Article: SCIENTIFIC REPORTS. 2020;10(1):923

VEGF-B ablation in pancreatic β-cells upregulates insulin expression without affecting glucose homeostasis or islet lipid uptake

Ning FC; Jensen N; Mi J; Lindstrom W; Balan M; Muhl L; Eriksson U; Nilsson I; Nyqvist D
Article: NEURORADIOLOGY. 2018;60(7):759-768

Transcriptomic analysis of the harvested endothelial cells in a swine model of mechanical thrombectomy

Jaff N; Grankvist R; Muhl L; Chireh A; Sandell M; Jonsson S; Arnberg F; Eriksson U; Holmin S
Article: AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2018;314(4):L593-L605

Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension

Tannenberg P; Chang Y-T; Muhl L; Lavina B; Gladh H; Genove G; Betsholtz C; Folestad E; Tran-Lundmark K
Article: PLOS ONE. 2018;13(7):e0200649

Preclinical toxicological assessment of a novel monoclonal antibody targeting human platelet-derived growth factor CC (PDGF-CC) in PDGF-CC^hum mice

Zeitelhofer M; Li H; Adzemovic MZ; Nilsson I; Muhl L; Scott AM; Eriksson U
Article: NATURE CELL BIOLOGY. 2017;19(6):639-652

Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling

Jin Y; Muhl L; Burmakin M; Wang Y; Duchez A-C; Betsholtz C; Arthur HM; Jakobsson L
Article: JOURNAL OF CELL SCIENCE. 2017;130(8):1365-1378

Neuropilin 1 binds PDGF-D and is a co-receptor in PDGF-D-PDGFRβ signaling

Muhl L; Folestad EB; Gladh H; Wang Y; Moessinger C; Jakobsson L; Eriksson U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(40):21020-21028

Transforming Growth Factor-β (TGF-β) Inhibits the Expression of Factor VII-activating Protease (FSAP) in Hepatocytes

Leiting S; Seidl S; Martinez-Palacian A; Muhl L; Kanse SM
Article: CELL AND TISSUE RESEARCH. 2016;365(1):51-63

Expression of vascular endothelial growth factor (VEGF)-B and its receptor (VEGFR1) in murine heart, lung and kidney

Muhl L; Moessinger C; Adzemovic MZ; Dijkstra MH; Nilsson I; Zeitelhofer M; Hagberg CE; Huusko J; Falkevall A; Yla-Herttuala S; Eriksson U
Article: ACTA NEUROPATHOLOGICA. 2016;131(3):453-464

Presymptomatic activation of the PDGF-CC pathway accelerates onset of ALS neurodegeneration

Lewandowski SA; Nilsson I; Fredriksson L; Lonnerberg P; Muhl L; Zeitelhofer M; Adzemovic MZ; Nichterwitz S; Lawrence DA; Hedlund E; Eriksson U
Article: PLOS ONE. 2016;11(3):e0152276

Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype

Gladh H; Folestad EB; Muhl L; Ehnman M; Tannenberg P; Lawrence A-L; Betsholtz C; Eriksson U
Article: NATURE PROTOCOLS. 2013;8(6):1149-1154

Imaging of neutral lipids by oil red O for analyzing the metabolic status in health and disease

Mehlem A; Hagberg CE; Muhl L; Eriksson U; Falkevall A
Article: THROMBOSIS RESEARCH. 2012;130(6):935-941

The Marburg I polymorphism of factor VII activating protease is associated with low proteolytic and low pro-coagulant activity.

Etscheid M; Muhl L; Pons D; Jukema JW; König H; Kanse SM
Article: NATURE. 2012;490(7420):426-430

Targeting VEGF-B as a novel treatment for insulin resistance and type 2 diabetes

Hagberg CE; Mehlem A; Falkevall A; Muhl L; Fam BC; Ortsater H; Scotney P; Nyqvist D; Samen E; Lu L; Stone-Elander S; Proietto J; Andrikopoulos S; Sjoholm A; Nash A; Eriksson U
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2

Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: FEBS JOURNAL. 2009;276(17):4828-4839

High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease.

Muhl L; Galuska SP; Oörni K; Hernández-Ruiz L; Andrei-Selmer L-C; Geyer R; Preissner KT; Ruiz FA; Kovanen PT; Kanse SM
Article: FEBS LETTERS. 2009;583(12):1994-1998

Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions.

Muhl L; Hersemeyer K; Preissner KT; Weimer T; Kanse SM
Article: THROMBOSIS AND HAEMOSTASIS. 2008;99(2):286-289

Factor VII-activating protease (FSAP): vascular functions and role in atherosclerosis.

Kanse SM; Parahuleva M; Muhl L; Kemkes-Matthes B; Sedding D; Preissner KT
Article: THROMBOSIS AND HAEMOSTASIS. 2007;98(6):1193-1199

Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms.

Katz B-Z; Muhl L; Zwang E; Ilan N; Herishanu Y; Deutsch V; Naparstek E; Vlodavsky I; Preissner KT
Article: BIOCHEMICAL JOURNAL. 2007;404(2):191-196

Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP.

Muhl L; Nykjaer A; Wygrecka M; Monard D; Preissner KT; Kanse SM
Article: BIOCHEMICAL JOURNAL. 2007;404(1):45-50

Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation.

Shibamiya A; Muhl L; Tannert-Otto S; Preissner KT; Kanse SM
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2006;203(13):2801-2807

The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation.

Sedding D; Daniel J-M; Muhl L; Hersemeyer K; Brunsch H; Kemkes-Matthes B; Braun-Dullaeus RC; Tillmanns H; Weimer T; Preissner KT; Kanse SM
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Review: NATURE COMMUNICATIONS. 2022;13(1):3409

Identification, discrimination and heterogeneity of fibroblasts

Lendahl U; Muhl L; Betsholtz C
Letter: CIRCULATION. 2021;143(8):865-868

Lack of Evidence of Angiotensin-Converting Enzyme 2 Expression and Replicative Infection by SARS-CoV-2 in Human Endothelial Cells

McCracken IR; Saginc G; He L; Huseynov A; Daniels A; Fletcher S; Peghaire C; Kalna V; Andaloussi-Mae M; Muhl L; Craig NM; Griffiths SJ; Haas JG; Tait-Burkard C; Lendahl U; Birdsey GM; Betsholtz C; Noseda M; Baker AH; Randi AM
Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):4493

Single-cell analysis uncovers fibroblast heterogeneity and criteria for fibroblast and mural cell identification and discrimination (Aug, 10.1038/s41467-020-17740-1, 2020)

Muhl L; Genove G; Leptidis S; Liu J; He L; Mocci G; Sun Y; Gustafsson S; Buyandelger B; Chivukula IV; Segerstolpe A; Raschperger E; Hansson EM; Bjoerkegren JLM; Peng X-R; Vanlandewijck M; Lendahl U; Betsholtz C
Review: CELLULAR NETWORKS IN DEVELOPMENT. 2017;123:433-482

VEGF Receptor Tyrosine Kinases: Key Regulators of Vascular Function

Alvarez-Aznar A; Muhl L; Gaengel K
Review: EUROPEAN JOURNAL OF HEART FAILURE. 2015;17(11):1091-1103

Intercellular communication lessons in heart failure

Bang C; Antoniades C; Antonopoulos AS; Eriksson U; Franssen C; Hamdani N; Lehmann L; Moessinger C; Mongillo M; Muhl L; Speer T; Thum T
Review: PHYSIOLOGY. 2013;28(2):125-134

Endothelial Fatty Acid Transport: Role of Vascular Endothelial Growth Factor B

Hagberg C; Mehlem A; Falkevall A; Muhl L; Eriksson U
Corrigendum: DEVELOPMENTAL CELL. 2012;23(6):1264

The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2 (vol 23, pg 587, 2012)

Gaengel K; Niaudet C; Hagikura K; Lavina B; Muhl L; Hofmann JJ; Ebarasi L; Nystroem S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstroem M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C

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