Lara Kular
Senior Forskningsspecialist
E-postadress: lara.kular@ki.se
Besöksadress: L8:05, CMM Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postadress: K8 Klinisk neurovetenskap, K8 Neuro Jagodic Kular, 171 77 Stockholm
Del av:
- Institutionen för klinisk neurovetenskap
- Avdelningen för neuro
- Funktionell (epi)genomik vid neuroinflammatoriska sjukdomar – Maja Jagodics forskargrupp
- Lung-brain Axis – Lara Kular
Om mig
Please see the English version. I am team Leader in Maja Jagodic's group of the Karolinska Neuroimmunology and Multiple Sclerosis (KNIMS) network.
Artiklar
- Article: EBIOMEDICINE. 2024;110:105470Lewandowski SA; Kular L; Jagodic M
- Article: NATURE COMMUNICATIONS. 2024;15(1):6419Kakhki MP; Giordano A; Cucuzza CS; Badam TVS; Samudyata S; Lemee MV; Stridh P; Gkogka A; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Hillert J; Olsson T; Kockum I; Sellgren CM; Golzio C; Kular L; Jagodic M
- Article: BRAIN, BEHAVIOR, & IMMUNITY - HEALTH. 2024;38:100787Kular L
- Article: ACTA NEUROPATHOLOGICA. 2024;147(1):82Windener F; Grewing L; Thomas C; Dorion M-F; Otteken M; Kular L; Jagodic M; Antel J; Albrecht S; Kuhlmann T
- Article: NATURE IMMUNOLOGY. 2024;25(3):432-447Linnerbauer M; Loesslein L; Vandrey O; Peter A; Han Y; Tsaktanis T; Wogram E; Needhamsen M; Kular L; Nagel L; Zissler J; Andert M; Meszaros L; Hanspach J; Zuber F; Naumann UJ; Diebold M; Wheeler MA; Beyer T; Nirschl L; Cirac A; Laun FB; Guenther C; Winkler J; Baeuerle T; Jagodic M; Hemmer B; Prinz M; Quintana FJ; Rothhammer V
- Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2023;79:104991Klose D; Needhamsen M; Ringh MV; Hagemann-Jensen M; Jagodic M; Kular L
- Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1251772Kalomoiri M; Prakash CR; Lagstroem S; Hauschulz K; Ewing E; Shchetynsky K; Kular L; Needhamsen M; Jagodic M
- Article: NEUROLOGY. 2023;101(7):e679-e689Maltby V; Xavier A; Ewing E; Campagna M-P; Sampangi S; Scott RJ; Butzkueven H; Jokubaitis V; Kular L; Bos S; Slee M; van der Mei IA; Taylor BV; Ponsonby A-L; Jagodic M; Lea R; Lechner-Scott J
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(16):12576Xavier A; Maltby VE; Ewing E; Campagna MP; Burnard SM; Tegner JN; Slee M; Butzkueven H; Kockum I; Kular L; Jokubaitis VG; Kilpatrick T; Alfredsson L; Jagodic M; Ponsonby A-L; Taylor BV; Scott RJ; Lea RA; Lechner-Scott J
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2023;160:217-224Bostrom AED; Jamshidi E; Manu D-M; Kular L; Schioth HB; Asberg M; Jokinen J
- Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:926468Kular L; Klose D; Urdanoz-Casado A; Ewing E; Planell N; Gomez-Cabrero D; Needhamsen M; Jagodic M
- Article: EPIGENETICS. 2022;17(11):1311-1330Kular L; Ewing E; Needhamsen M; Kakhki MP; Covacu R; Gomez-Cabrero D; Brundin L; Jagodic M
- Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(7):1014-1026Ringh MV; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Jagodic M; Ekstrom TJ; Ockinger J; Kular L
- Article: CLINICAL EPIGENETICS. 2020;12(1):99Ciuculete DM; Voisin S; Kular L; Jonsson J; Rask-Andersen M; Mwinyi J; Schioth HB
- Article: EPIGENETICS. 2020;15(6-7):646-663Ciuculete DM; Voisin S; Kular L; Welihinda N; Jonsson J; Jagodic M; Mwinyi J; Schioth HB
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(2):838-852N'diaye M; Brauner S; Flytzani S; Kular L; Warnecke A; Adzemovic MZ; Piket E; Min J-H; Edwards W; Mela F; Choi HY; Magg V; James T; Linden M; Reichardt HM; Daws MR; van Horssen J; Kockum I; Harris RA; Olsson T; Guerreiro-Cacais AO; Jagodic M
- Article: EBIOMEDICINE. 2019;46:290-304Ringh MV; Hagemann-Jensen M; Needhamsen M; Kular L; Breeze CE; Sjoholm LK; Slavec L; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Liu Y; Almgren M; Jagodic M; Ockinger J; Ekstrom TJ
- Article: JOURNAL OF AUTOIMMUNITY. 2019;101:17-25Piket E; Zheleznyakova GY; Kular L; Jagodic M
- Article: CLINICAL EPIGENETICS. 2019;11(1):86Kular L; Needhamsen M; Adzemovic MZ; Kramarova T; Gomez-Cabrero D; Ewing E; Piket E; Tegner J; Beck S; Piehl F; Brundin L; Jagodic M
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452Li D; Kular L; Vij M; Herter EK; Li X; Wang A; Chu T; Toma M-A; Zhang L; Liapi E; Mota A; Blomqvist L; Serezal IG; Rollman O; Wikstrom JD; Bienko M; Berglund D; Stahle M; Sommar P; Jagodic M; Landen NX
- Article: EBIOMEDICINE. 2019;43:411-423Ewing E; Kular L; Fernandes SJ; Karathanasis N; Lagani V; Ruhrmann S; Tsamardinos I; Tegner J; Piehl F; Gomez-Cabrero D; Jagodic M
- Article: NATURE COMMUNICATIONS. 2018;9(1):4845Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
- Article: MULTIPLE SCLEROSIS JOURNAL. 2018;24(10):1288-1300Ruhrmann S; Ewing E; Piket E; Kular L; Lorenzi JCC; Fernandes SJ; Morikawa H; Aeinehband S; Sayols-Baixeras S; Aslibekyan S; Absher DM; Arnett DK; Tegner J; Gomez-Cabrero D; Piehl F; Jagodic M
- Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2018;102:44-51Ciuculete DM; Bostrom AE; Tuunainen A-K; Sohrabi F; Kular L; Jagodic M; Voisin S; Mwinyi J; Schioth HB
- Article: NATURE COMMUNICATIONS. 2018;9(1):2397Kular L; Liu Y; Ruhrmann S; Zheleznyakova G; Marabita F; Gomez-Cabrero D; James T; Ewing E; Linden M; Gornikiewicz B; Aeinehband S; Stridh P; Link J; Andlauer TFM; Gasperi C; Wiendl H; Zipp F; Gold R; Tackenberg B; Weber F; Hemmer B; Strauch K; Heilmann-Heimbach S; Rawal R; Schminke U; Schmidt CO; Kacprowski T; Franke A; Laudes M; Dilthey AT; Celius EG; Sondergaard HB; Tegner J; Harbo HF; Oturai AB; Olafsson S; Eggertsson HP; Halldorsson BV; Hjaltason H; Olafsson E; Jonsdottir I; Stefansson K; Olsson T; Piehl F; Ekstroem TJ; Kockum I; Feinberg AP; Jagodic M
- Article: NATURE IMMUNOLOGY. 2018;19(5):1-7Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
- Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Ulum YZA; Zhang L; Landen NX; Girnita L; Jagodic M; Stahle M; Sonkoly E; Pivarcsi A
- Journal article: SCIENTIFIC REPORTS. 2018;8(1):4340Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(6):479-485Ghafelehbashi H; Kakhki MP; Kular L; Moghbelinejad S; Ghafelehbashi SH
- Article: BMC BIOINFORMATICS. 2017;18(1):486Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
- Article: SCIENTIFIC REPORTS. 2017;7(1):14589Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
- Article: JOURNAL OF IMMUNOLOGY. 2013;190(8):4066-4075Bergman P; James T; Kular L; Ruhrmann S; Kramarova T; Kvist A; Supic G; Gillett A; Pivarcsi A; Jagodic M
- Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:36Kular L; Rivat C; Lelongt B; Calmel C; Laurent M; Pohl M; Kitabgi P; Melik-Parsadaniantz S; Martinerie C
- Article: GLIA. 2010;58(12):1510-1521Le Dréau G; Kular L; Nicot AB; Calmel C; Melik-Parsadaniantz S; Kitabgi P; Laurent M; Martinerie C
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Alla övriga publikationer
- Review: JOURNAL OF INTERNAL MEDICINE. 2020;288(1):82-102Kular L; Jagodic M
- Review: EVOLUTION PSYCHIATRIQUE. 2019;84(1):207-221Kular S; Kular L
- Review: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2018;72(4):195-211Kular L; Kular S
- Review: PHYSIOLOGICAL GENOMICS. 2017;49(9):447-461Zheleznyakova GY; Piket E; Marabita F; Kakhki MP; Ewing E; Ruhrmann S; Needhamsen M; Jagodic M; Kular L
- Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2015;67:49-57Ruhrmann S; Stridh P; Kular L; Jagodic M
- Review: BIOCHIMIE. 2011;93(3):377-388Kular L; Pakradouni J; Kitabgi P; Laurent M; Martinerie C
- Review: FRONTIERS IN NEUROENDOCRINOLOGY. 2011;32(1):10-24Rostène W; Guyon A; Kular L; Godefroy D; Barbieri F; Bajetto A; Banisadr G; Callewaere C; Conductier G; Rovère C; Mélik-Parsadaniantz S; Florio T
Forskningsbidrag
- Swedish Research Council1 January 2022 - 31 December 2025Multiple Sclerosis (MS), inflammatory disease of the central nervous system, is a leading cause of unpredictable lifelong disability in young adults, with a yet unexplained rise in incidence. Despite the known association between smoking and MS, the underlying mechanisms are still elusive and specific clinical applications are lacking. We propose that epigenetic mechanisms mediate the processes underpinning the impact of smoking in MS. We aim to develop innovative analytical and cutting-edge experimental strategies, taking advantage of the stable and reversible nature of epigenetic marks to:Aim 1. Identify novel molecular mechanisms underlying the impact of smoking in MS by generating omics data in pathogenic immune cells of the lung-brain axis and in relation to the major HLA MS risk factor and brain degeneration using case-control cohorts.Aim 2. Functionally investigate smoking-associated changes using epigenome-editing in advanced (e.g. iPSC-derived) cellular models and in MS-like animal model.Aim 3. Establish smoking-associated epigenetic marks that can serve as sensitive and specific biomarkers for early diagnosis and prognosis.With this project, we will translate findings from unique clinical material into advanced functional systems and address biomarker potential. We believe this unprecedented approach will provide in-depth mechanistic insights into the impact of smoking, considerably advancing the field of MS and potentially other diseases with similar etiologies.