Lara Kular

Om mig
Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Om mig

Please see the English version. I am team Leader in Maja Jagodic's group of the Karolinska Neuroimmunology and Multiple Sclerosis (KNIMS) network.

Artiklar

Article: EBIOMEDICINE. 2024;110:105470
Epigenetic age acceleration as a biomarker of amyotrophic lateral sclerosis severity?
Lewandowski SA; Kular L; Jagodic M
Article: NATURE COMMUNICATIONS. 2024;15(1):6419
A genetic-epigenetic interplay at 1q21.1 locus underlies CHD1L-mediated vulnerability to primary progressive multiple sclerosis
Kakhki MP; Giordano A; Cucuzza CS; Badam TVS; Samudyata S; Lemee MV; Stridh P; Gkogka A; Shchetynsky K; Harroud A; Gyllenberg A; Liu Y; Boddul S; James T; Sorosina M; Filippi M; Esposito F; Wermeling F; Gustafsson M; Casaccia P; Hillert J; Olsson T; Kockum I; Sellgren CM; Golzio C; Kular L; Jagodic M
Article: BRAIN, BEHAVIOR, & IMMUNITY - HEALTH. 2024;38:100787
The lung-brain axis in multiple sclerosis: Mechanistic insights and future directions
Kular L
Article: ACTA NEUROPATHOLOGICA. 2024;147(1):82
Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS
Windener F; Grewing L; Thomas C; Dorion M-F; Otteken M; Kular L; Jagodic M; Antel J; Albrecht S; Kuhlmann T
Article: NATURE IMMUNOLOGY. 2024;25(3):432-447
The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology
Linnerbauer M; Loesslein L; Vandrey O; Peter A; Han Y; Tsaktanis T; Wogram E; Needhamsen M; Kular L; Nagel L; Zissler J; Andert M; Meszaros L; Hanspach J; Zuber F; Naumann UJ; Diebold M; Wheeler MA; Beyer T; Nirschl L; Cirac A; Laun FB; Guenther C; Winkler J; Baeuerle T; Jagodic M; Hemmer B; Prinz M; Quintana FJ; Rothhammer V
Article: MULTIPLE SCLEROSIS AND RELATED DISORDERS. 2023;79:104991
Smoking affects epigenetic ageing of lung bronchoalveolar lavage cells in Multiple Sclerosis
Klose D; Needhamsen M; Ringh MV; Hagemann-Jensen M; Jagodic M; Kular L
Article: NEUROLOGY. 2023;101(7):e679-e689
Evaluation of Cell-Specific Epigenetic Age Acceleration in People With Multiple Sclerosis
Maltby V; Xavier A; Ewing E; Campagna M-P; Sampangi S; Scott RJ; Butzkueven H; Jokubaitis V; Kular L; Bos S; Slee M; van der Mei IA; Taylor BV; Ponsonby A-L; Jagodic M; Lea R; Lechner-Scott J
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(16):12576
DNA Methylation Signatures of Multiple Sclerosis Occur Independently of Known Genetic Risk and Are Primarily Attributed to B Cells and Monocytes
Xavier A; Maltby VE; Ewing E; Campagna MP; Burnard SM; Tegner JN; Slee M; Butzkueven H; Kockum I; Kular L; Jokubaitis VG; Kilpatrick T; Alfredsson L; Jagodic M; Ponsonby A-L; Taylor BV; Scott RJ; Lea RA; Lechner-Scott J
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2023;160:217-224
Epigenetic changes in the CYP2D6 gene are related to severity of suicide attempt: A cross-sectional study of suicide attempters
Bostrom AED; Jamshidi E; Manu D-M; Kular L; Schioth HB; Asberg M; Jokinen J
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1251772
Simultaneous detection of DNA variation and methylation at HLA class II locus and immune gene promoters using targeted SureSelect Methyl-Sequencing
Kalomoiri M; Prakash CR; Lagstroem S; Hauschulz K; Ewing E; Shchetynsky K; Kular L; Needhamsen M; Jagodic M
Article: EPIGENETICS. 2022;17(11):1311-1330
DNA methylation changes in glial cells of the normal-appearing white matter in Multiple Sclerosis patients
Kular L; Ewing E; Needhamsen M; Kakhki MP; Covacu R; Gomez-Cabrero D; Brundin L; Jagodic M
Article: FRONTIERS IN AGING NEUROSCIENCE. 2022;14:926468
Epigenetic clock indicates accelerated aging in glial cells of progressive multiple sclerosis patients
Kular L; Klose D; Urdanoz-Casado A; Ewing E; Planell N; Gomez-Cabrero D; Needhamsen M; Jagodic M
Article: MULTIPLE SCLEROSIS JOURNAL. 2021;27(7):1014-1026
Methylome and transcriptome signature of bronchoalveolar cells from multiple sclerosis patients in relation to smoking
Ringh MV; Hagemann-Jensen M; Needhamsen M; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Jagodic M; Ekstrom TJ; Ockinger J; Kular L
Article: EPIGENETICS. 2020;15(6-7):646-663
Longitudinal DNA methylation changes at MET may alter HGF/c-MET signalling in adolescents at risk for depression
Ciuculete DM; Voisin S; Kular L; Welihinda N; Jonsson J; Jagodic M; Mwinyi J; Schioth HB
Article: CLINICAL EPIGENETICS. 2020;12(1):99
meQTL and ncRNA functional analyses of 102 GWAS-SNPs associated with depression implicate HACE1 and SHANK2 genes
Ciuculete DM; Voisin S; Kular L; Jonsson J; Rask-Andersen M; Mwinyi J; Schioth HB
Article: JOURNAL OF CLINICAL INVESTIGATION. 2020;130(2):838-852
C-type lectin receptors Mcl and Mincle contro development of multiple sclerosis like neuroinflammation
N'diaye M; Brauner S; Flytzani S; Kular L; Warnecke A; Adzemovic MZ; Piket E; Min J-H; Edwards W; Mela F; Choi HY; Magg V; James T; Linden M; Reichardt HM; Daws MR; van Horssen J; Kockum I; Harris RA; Olsson T; Guerreiro-Cacais AO; Jagodic M
Article: EBIOMEDICINE. 2019;46:290-304
Tobacco smoking induces changes in true DNA methylation, hydroxymethylation and gene expression in bronchoalveolar lavage cells
Ringh MV; Hagemann-Jensen M; Needhamsen M; Kular L; Breeze CE; Sjoholm LK; Slavec L; Kullberg S; Wahlstrom J; Grunewald J; Brynedal B; Liu Y; Almgren M; Jagodic M; Ockinger J; Ekstrom TJ
Article: JOURNAL OF AUTOIMMUNITY. 2019;101:17-25
Small non-coding RNAs as important players, biomarkers and therapeutic targets in multiple sclerosis: A comprehensive overview
Piket E; Zheleznyakova GY; Kular L; Jagodic M
Article: CLINICAL EPIGENETICS. 2019;11(1):86
Neuronal methylome reveals CREB-associated neuro-axonal impairment in multiple sclerosis
Kular L; Needhamsen M; Adzemovic MZ; Kramarova T; Gomez-Cabrero D; Ewing E; Piket E; Tegner J; Beck S; Piehl F; Brundin L; Jagodic M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2019;116(19):9443-9452
Human skin long noncoding RNA WAKMAR1 regulates wound healing by enhancing keratinocyte migration
Li D; Kular L; Vij M; Herter EK; Li X; Wang A; Chu T; Toma M-A; Zhang L; Liapi E; Mota A; Blomqvist L; Serezal IG; Rollman O; Wikstrom JD; Bienko M; Berglund D; Stahle M; Sommar P; Jagodic M; Landen NX
Article: EBIOMEDICINE. 2019;43:411-423
Combining evidence from four immune cell types identifies DNA methylation patterns that implicate functionally distinct pathways during Multiple Sclerosis progression
Ewing E; Kular L; Fernandes SJ; Karathanasis N; Lagani V; Ruhrmann S; Tsamardinos I; Tegner J; Piehl F; Gomez-Cabrero D; Jagodic M
Article: NATURE COMMUNICATIONS. 2018;9(1):4845
Competitive repopulation of an empty microglial niche yields functionally distinct subsets of microglia-like cells
Lund H; Pieber M; Parsa R; Han J; Grommisch D; Ewing E; Kular L; Needhamsen M; Espinosa A; Nilsson E; Overby AK; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: MULTIPLE SCLEROSIS JOURNAL. 2018;24(10):1288-1300
Hypermethylation of MIR21 in CD4+T cells from patients with relapsing-remitting multiple sclerosis associates with lower miRNA-21 levels and concomitant up-regulation of its target genes
Ruhrmann S; Ewing E; Piket E; Kular L; Lorenzi JCC; Fernandes SJ; Morikawa H; Aeinehband S; Sayols-Baixeras S; Aslibekyan S; Absher DM; Arnett DK; Tegner J; Gomez-Cabrero D; Piehl F; Jagodic M
Article: JOURNAL OF PSYCHIATRIC RESEARCH. 2018;102:44-51
Changes in methylation within the STK32B promoter are associated with an increased risk for generalized anxiety disorder in adolescents
Ciuculete DM; Bostrom AE; Tuunainen A-K; Sohrabi F; Kular L; Jagodic M; Voisin S; Mwinyi J; Schioth HB
Article: NATURE COMMUNICATIONS. 2018;9(1):2397
DNA methylation as a mediator of HLA-DRB1^☆15:01 and a protective variant in multiple sclerosis
Kular L; Liu Y; Ruhrmann S; Zheleznyakova G; Marabita F; Gomez-Cabrero D; James T; Ewing E; Linden M; Gornikiewicz B; Aeinehband S; Stridh P; Link J; Andlauer TFM; Gasperi C; Wiendl H; Zipp F; Gold R; Tackenberg B; Weber F; Hemmer B; Strauch K; Heilmann-Heimbach S; Rawal R; Schminke U; Schmidt CO; Kacprowski T; Franke A; Laudes M; Dilthey AT; Celius EG; Sondergaard HB; Tegner J; Harbo HF; Oturai AB; Olafsson S; Eggertsson HP; Halldorsson BV; Hjaltason H; Olafsson E; Jonsdottir I; Stefansson K; Olsson T; Piehl F; Ekstroem TJ; Kockum I; Feinberg AP; Jagodic M
Article: NATURE IMMUNOLOGY. 2018;19(5):1-7
Fatal demyelinating disease is induced by monocyte-derived macrophages in the absence of TGF-β signaling
Lund H; Pieber M; Parsa R; Grommisch D; Ewing E; Kular L; Han J; Zhu K; Nijssen J; Hedlund E; Needhamsen M; Ruhrmann S; Guerreiro-Cacais AO; Berglund R; Forteza MJ; Ketelhuth DFJ; Butovsky O; Jagodic M; Zhang X-M; Harris RA
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2018;138(4):882-892
Genome-Wide Screen for MicroRNAs Reveals a Role for miR-203 in Melanoma Metastasis
Lohcharoenkal W; Das Mahapatra K; Pasquali L; Crudden C; Kular L; Ulum YZA; Zhang L; Landen NX; Girnita L; Jagodic M; Stahle M; Sonkoly E; Pivarcsi A
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(6):479-485
Decreased Expression of IFNG-AS1, IFNG and IL-1B Inflammatory Genes in Medicated Schizophrenia and Bipolar Patients
Ghafelehbashi H; Kakhki MP; Kular L; Moghbelinejad S; Ghafelehbashi SH
Article: BMC BIOINFORMATICS. 2017;18(1):486
Usability of human Infinium MethylationEPIC BeadChip for mouse DNA methylation studies
Needhamsen M; Ewing E; Lund H; Gomez-Cabrero D; Harris RA; Kular L; Jagodic M
Article: SCIENTIFIC REPORTS. 2017;7(1):14589
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship
Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
Article: JOURNAL OF IMMUNOLOGY. 2013;190(8):4066-4075
Next-Generation Sequencing Identifies MicroRNAs that Associate with Pathogenic Autoimmune Neuroinflammation in Rats
Bergman P; James T; Kular L; Ruhrmann S; Kramarova T; Kvist A; Supic G; Gillett A; Pivarcsi A; Jagodic M
Article: JOURNAL OF NEUROINFLAMMATION. 2012;9:36
NOV/CCN3 attenuates inflammatory pain through regulation of matrix metalloproteinases-2 and -9.
Kular L; Rivat C; Lelongt B; Calmel C; Laurent M; Pohl M; Kitabgi P; Melik-Parsadaniantz S; Martinerie C
Article: GLIA. 2010;58(12):1510-1521
NOV/CCN3 upregulates CCL2 and CXCL1 expression in astrocytes through beta1 and beta5 integrins.
Le Dréau G; Kular L; Nicot AB; Calmel C; Melik-Parsadaniantz S; Kitabgi P; Laurent M; Martinerie C
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Alla övriga publikationer

Review: JOURNAL OF INTERNAL MEDICINE. 2020;288(1):82-102
Epigenetic insights into multiple sclerosis disease progression
Kular L; Jagodic M
Review: EVOLUTION PSYCHIATRIQUE. 2019;84(1):207-221
Epigenetics as a partner of psychiatry: Toward a personalized approach of the patient
Kular S; Kular L
Review: PSYCHIATRY AND CLINICAL NEUROSCIENCES. 2018;72(4):195-211
Epigenetics applied to psychiatry: Clinical opportunities and future challenges
Kular L; Kular S
Corrigendum: SCIENTIFIC REPORTS. 2018;8(1):4340
Smoking induces DNA methylation changes in Multiple Sclerosis patients with exposure-response relationship (vol 7, 14589, 2017)
Marabita F; Almgren M; Sjoholm LK; Kular L; Liu Y; James T; Kiss NB; Feinberg AP; Olsson T; Kockum I; Alfredsson L; Ekstrom TJ; Jagodic M
Review: PHYSIOLOGICAL GENOMICS. 2017;49(9):447-461
Epigenetic research in multiple sclerosis: progress, challenges, and opportunities
Zheleznyakova GY; Piket E; Marabita F; Kakhki MP; Ewing E; Ruhrmann S; Needhamsen M; Jagodic M; Kular L
Review: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2015;67:49-57
Genomic imprinting: A missing piece of the Multiple Sclerosis puzzle?
Ruhrmann S; Stridh P; Kular L; Jagodic M
Review: BIOCHIMIE. 2011;93(3):377-388
The CCN family: a new class of inflammation modulators?
Kular L; Pakradouni J; Kitabgi P; Laurent M; Martinerie C
Review: FRONTIERS IN NEUROENDOCRINOLOGY. 2011;32(1):10-24
Chemokines and chemokine receptors: new actors in neuroendocrine regulations.
Rostène W; Guyon A; Kular L; Godefroy D; Barbieri F; Bajetto A; Banisadr G; Callewaere C; Conductier G; Rovère C; Mélik-Parsadaniantz S; Florio T

Forskningsbidrag

Epigenetics of the lung-brain axis in Multiple Sclerosis: unravelling the impact of smoking on disease pathogenesis and progression
Swedish Research Council
1 January 2022 - 31 December 2025

Om mig

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