Knut Steffensen

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: ADVANCED SCIENCE. 2024;11(20):2307201
Reprogramming of the LXRα Transcriptome Sustains Macrophage Secondary Inflammatory Responses
de la Rosa JV; Tabraue C; Huang Z; Orizaola MC; Martin-Rodriguez P; Steffensen KR; Zapata JM; Bosca L; Tontonoz P; Alemany S; Treuter E; Castrillo A
Article: MOLECULAR ONCOLOGY. 2023;17(10):2041-2055
Liver X receptors induce antiproliferative effects in basal-like breast cancer
Haugen MH; Gythfeldt HVDL; Egeland EV; Normann LS; Pandya ADD; Vedin L-L; Juell S; Tenstad E; oy GF; Kristian A; Marangoni E; Sorlie T; Steffensen K; Maelandsmo GM; Engebraaten O
Article: JOURNAL OF INTERNAL MEDICINE. 2022;292(2):296-307
Soat2 ties cholesterol metabolism to β-oxidation and glucose tolerance in male mice
Pramfalk C; Ahmed O; Pedrelli M; Minniti ME; Luquet S; Denis RG; Olin M; Hardfeldt J; Vedin L-L; Steffensen KR; Ryden M; Hodson L; Eriksson M; Parini P
Article: JOURNAL OF AUTOIMMUNITY. 2021;124:102723
Liver X receptor beta deficiency attenuates autoimmune-associated neuroinflammation in a T cell-dependent manner
Bogie JFJ; Vanmierlo T; Vanmol J; Timmermans S; Mailleux J; Nelissen K; Wijnands E; Wouters K; Stinissen P; Gustafsson J-A; Steffensen KR; Mulder M; Zelcer N; Hendriks JJA
Article: HEPATOLOGY. 2020;72(2):656-670
Insights From Liver-Humanized Mice on Cholesterol Lipoprotein Metabolism and LXR-Agonist Pharmacodynamics in Humans
Minniti ME; Pedrelli M; Vedin L-L; Delbes A-S; Denis RGP; Oorni K; Sala C; Pirazzini C; Thiagarajan D; Nurmi HJ; Grompe M; Mills K; Garagnani P; Ellis ECS; Strom SC; Luquet SH; Wilson EM; Bial J; Steffensen KR; Parini P
Article: CELL REPORTS. 2020;31(5):107601
Srebf1 Controls Midbrain Dopaminergic Neurogenesis
Toledo EM; Yang S; Gyllborg D; van Wijk KE; Sinha I; Varas-Godoy M; Grigsby CL; Lonnerberg P; Islam S; Steffensen KR; Linnarsson S; Arenas E
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2020;499:110604
Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity
Gnocchi D; Ellis ECS; Johansson H; Eriksson M; Bruscalupi G; Steffensen KR; Parini P
Article: DIGESTIVE AND LIVER DISEASE. 2019;51(7):1016-1022
Genetic depletion of Soat2 diminishes hepatic steatosis via genes regulating de novo lipogenesis and by GLUT2 protein in female mice
Ahmed O; Pramfalk C; Pedrelli M; Olin M; Steffensen KR; Eriksson M; Parini P
Article: ONCOIMMUNOLOGY. 2019;8(3):1554967
Nuclear receptor ligands induce TREM-1 expression on dendritic cells: analysis of their role in tumors
Fontana R; Raccosta L; Rovati L; Steffensen KR; Paniccia A; Jakobsson T; Melloni G; Bandiera A; Mangili G; Bergamini A; Maggioni D; Doglioni C; Crocchiolo R; Cella M; Mattioli M; Battaglia C; Colonna M; Russo V
Article: CELL REPORTS. 2019;26(4):984-995.e6
Impaired LXRα Phosphorylation Attenuates Progression of Fatty Liver Disease
Becares N; Gage MC; Voisin M; Shrestha E; Martin-Gutierrez L; Liang N; Louie R; Pourcet B; Pello OM; Luong TV; Goni S; Pichardo-Almarza C; Roberg-Larsen H; Diaz-Zuccarini V; Steffensen KR; O'Brien A; Garabedian MJ; Rombouts K; Treuter E; Pineda-Torra I
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1811
Liver X Receptor Alpha Is Important in Maintaining Blood-Brain Barrier Function
Wouters E; de Wit NM; Vanmol J; van der Pol SMA; Hof BVH; Sommer D; Loix M; Geerts D; Gustafsson JA; Steffensen KR; Vanmierlo T; Bogie JFJ; Hendriks JJA; de Vries HE
Article: IMMUNITY INFLAMMATION AND DISEASE. 2016;4(3):350-361
Cholesterol-sensing liver X receptors stimulate Th2-driven allergic eosinophilic asthma in mice
Smet M; Van Hoecke L; De Beuckelaer A; Vander Beken S; Naessens T; Vergote K; Willart M; Lambrecht BN; Gustafsson J-A; Steffensen KR; Grooten J
Journal article: SCIENTIFIC REPORTS. 2016;6:25481
The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms
Pourcet B; Gage MC; Leon TE; Waddington KE; Pello OM; Steffensen KR; Castrillo A; Valledor AF; Pineda-Torra I
Journal article: DIABETOLOGIA. 2016;59(3):634-643
LXRα improves myocardial glucose tolerance and reduces cardiac hypertrophy in a mouse model of obesity-induced type 2 diabetes
Cannon MV; Sillje HHW; Sijbesma JWA; Khan MAF; Steffensen KR; van Gilst WH; de Boer RA
Article: LABORATORY INVESTIGATION. 2016;96(2):230-238
Nuclear hormone receptor LXRα inhibits adipocyte differentiation of mesenchymal stem cells with Wnt/beta-catenin signaling
Matsushita K; Morello F; Zhang Z; Masuda T; Iwanaga S; Steffensen KR; Gustafsson J-A; Pratt RE; Dzau VJ
Journal article: CANCER CELL. 2015;28(1):3-4
Are Synthetic Compounds that Silence the Liver-X-Receptor the Next Generation of Anti-cancer Drugs?
Steffensen KR
Journal article: JOURNAL OF LIPID RESEARCH. 2015;56(4):771-785
Liver X receptor regulates hepatic nuclear O-GlcNAc signaling and carbohydrate responsive element-binding protein activity
Bindesboll C; Fan Q; Norgaard RC; MacPherson L; Ruan H-B; Wu J; Pedersen TA; Steffensen KR; Yang X; Matthews J; Mandrup S; Nebb HI; Gronning-Wang LM
Journal article: NUCLEAR RECEPTOR RESEARCH. 2015;2
LXR Inhibits Proliferation of Human Breast Cancer Cells through the PI3K-Akt Pathway
Hassan TS; Paniccia A; Russo V; Steffensen KR
Article: JOURNAL OF CLINICAL INVESTIGATION. 2014;124(11):4829-4842
Cholestenoic acids regulate motor neuron survival via liver X receptors
Theofilopoulos S; Griffiths WJ; Crick PJ; Yang S; Meljon A; Ogundare M; Kitambi SS; Lockhart A; Tuschl K; Clayton PT; Morris AA; Martinez A; Reddy MA; Martinuzzi A; Bassi MT; Honda A; Mizuochi T; Kimura A; Nittono H; De Michele G; Carbone R; Criscuolo C; Yau JL; Seckl JR; Schuele R; Schoels L; Sailer AW; Kuhle J; Fraidakis MJ; Gustafsson J-A; Steffensen KR; Bjorkhem I; Ernfors P; Sjovall J; Arenas E; Wang Y
Article: MUCOSAL IMMUNOLOGY. 2014;7(6):1416-1428
The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice
Jakobsson T; Vedin L-L; Hassan T; Venteclef N; Greco D; D'Amato M; Treuter E; Gustafsson J-A; Steffensen KR
Journal article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2014;44(7):1896-1903
LXR-dependent and -independent effects of oxysterols on immunity and tumor growth
Traversari C; Sozzani S; Steffensen KR; Russo V
Article: HEPATOLOGY. 2014;59(5):1791-1802
Estrogen Receptor Ligands Ameliorate Fatty Liver Through a Nonclassical Estrogen Receptor/Liver X Receptor Pathway in Mice
Han S-I; Komatsu Y; Murayama A; Steffensen KR; Nakagawa Y; Nakajima Y; Suzuki M; Oie S; Parini P; Vedin L-L; Kishimoto H; Shimano H; Gustafsson J-A; Yanagisawa J
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2014;306(5):E494-E502
Skeletal muscle as a target of LXR agonist after long-term treatment: focus on lipid homeostasis
Archer A; Laurencikiene J; Ahmed O; Steffensen KR; Parini P; Gustafsson J-A; Korach-Andre M
Article: PLOS ONE. 2014;9(4):e93552
Hepatic ACAT2 Knock Down Increases ABCA1 and Modifies HDL Metabolism in Mice
Pedrelli M; Davoodpour P; Degirolamo C; Gomaraschi M; Graham M; Ossoli A; Larsson L; Calabresi L; Gustafsson J-A; Steffensen KR; Eriksson M; Parini P
Article: LIPIDS. 2014;49(1):71-83
LXR Driven Induction of HDL-Cholesterol is Independent of Intestinal Cholesterol Absorption and ABCA1 Protein Expression
Kannisto K; Gafvels M; Jiang Z-Y; Slatis K; Hu X; Jorns C; Steffensen KR; Eggertsen G
Article: PLOS ONE. 2014;9(9):e106289
Antiproliferative Effects and Mechanisms of Liver X Receptor Ligands in Pancreatic Ductal Adenocarcinoma Cells
Candelaria NR; Addanki S; Zheng J; Trang N-V; Karaboga H; Dey P; Gabbi C; Vedin L-L; Liu K; Wu W; Jonsson PK; Lin JZ; Su F; Bollu LR; Hodges SE; McElhany AL; Issazadeh MA; Fisher WE; Ittmann MM; Steffensen KR; Gustafsson J-A; Lin C-Y
Journal article: PLOS ONE. 2014;9(9):e106983
Liver X Receptor Regulation of Thyrotropin-Releasing Hormone Transcription in Mouse Hypothalamus Is Dependent on Thyroid Status
Ghaddab-Zroud R; Seugnet I; Steffensen KR; Demeneix BA; Clerget-Froidevaux M-S
Article: MOLECULAR CARCINOGENESIS. 2013;52(11):835-844
The oxysterol receptors LXRα and LXRβ suppress proliferation in the colon.
Vedin L-L; Gustafsson J-Å; Steffensen KR
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2013;210(9):1711-1728
The oxysterol-CXCR2 axis plays a key role in the recruitment of tumor-promoting neutrophils
Raccosta L; Fontana R; Maggioni D; Lanterna C; Villablanca EJ; Paniccia A; Musumeci A; Chiricozzi E; Trincavelli ML; Daniele S; Martini C; Gustafsson J-A; Doglioni C; Feo SG; Leiva A; Ciampa MG; Mauri L; Sensi C; Prinetti A; Eberini I; Mora JR; Bordignon C; Steffensen KR; Sonnino S; Sozzani S; Traversari C; Russo V
Article: BREAST CANCER RESEARCH. 2013;15(3):R51
Liver x receptor ligands disrupt breast cancer cell proliferation through an E2F-mediated mechanism
Trang N-V; Vedin L-L; Liu K; Jonsson P; Lin JZ; Candelaria NR; Candelaria LP; Addanki S; Williams C; Gustafsson J-A; Steffensen KR; Lin C-Y
Article: JOURNAL OF IMMUNOLOGY. 2013;190(12):6520-6532
Reciprocal Negative Cross-Talk between Liver X Receptors (LXRs) and STAT1: Effects on IFN-γ-Induced Inflammatory Responses and LXR-Dependent Gene Expression
Pascual-Garcia M; Rue L; Leon T; Julve J; Maria Carbo J; Matalonga J; Auer H; Celada A; Carles Escola-Gil J; Steffensen KR; Perez-Navarro E; Valledor AF
Article: NATURE CHEMICAL BIOLOGY. 2013;9(2):126-133
Brain endogenous liver X receptor ligands selectively promote midbrain neurogenesis
Theofilopoulos S; Wang Y; Kitambi SS; Sacchetti P; Sousa KM; Bodin K; Kirk J; Salto C; Gustafsson M; Toledo EM; Karu K; Gustafsson J-A; Steffensen KR; Ernfors P; Sjovall J; Griffiths WJ; Arenas E
Article: JOURNAL OF INTERNAL MEDICINE. 2012;272(5):452-464
LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile
Hu X; Steffensen KR; Jiang Z-Y; Parini P; Gustafsson J-A; Gafvels M; Eggertsen G
Article: DIABETOLOGIA. 2012;55(9):2469-2478
Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice
Gonzalez-Granillo M; Steffensen KR; Granados O; Torres N; Korach-Andre M; Ortiz V; Aguilar-Salinas C; Jakobsson T; Diaz-Villasenor A; Loza-Valdes A; Hernandez-Pando R; Gustafsson J-A; Tovar AR
Article: MOLECULAR AND CELLULAR BIOLOGY. 2012;32(4):852-867
Genome-Wide Profiling of Liver X Receptor, Retinoid X Receptor, and Peroxisome Proliferator-Activated Receptor α in Mouse Liver Reveals Extensive Sharing of Binding Sites
Boergesen M; Pedersen TA; Gross B; van Heeringen SJ; Hagenbeek D; Bindesboll C; Caron S; Lalloyer F; Steffensen KR; Nebb HI; Gustafsson J-A; Stunnenberg HG; Staels B; Mandrup S
Article: BMC GENOMICS. 2012;13:50
Genome-wide landscape of liver X receptor chromatin binding and gene regulation in human macrophages
Pehkonen P; Welter-Stahl L; Diwo J; Ryynanen J; Wienecke-Baldacchino A; Heikkinen S; Treuter E; Steffensen KR; Carlberg C
Article: PLOS ONE. 2012;7(9):e44998
Myelin-Derived Lipids Modulate Macrophage Activity by Liver X Receptor Activation
Bogie JFJ; Timmermans S; Van AH-T; Irrthum A; Smeets HJM; Gustafsson J-A; Steffensen KR; Mulder M; Stinissen P; Hellings N; Hendriks JJA
Article: SURGICAL INFECTIONS. 2011;12(4):283-289
Liver X Receptor Protects against Liver Injury in Sepsis Caused by Rodent Cecal Ligation and Puncture
Wang YY; Ryg U; Dahle MK; Steffensen KR; Thiemermann C; Chaudry IH; Reinholt FP; Collins JL; Nebb HI; Aasen AO; Gustafsson J-A; Wang JE
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2011;301(1):E210-E222
Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice
Korach-Andre M; Archer A; Gabbi C; Barros RP; Pedrelli M; Steffensen KR; Pettersson AT; Laurencikiene J; Parini P; Gustafsson J-A
Article: JOURNAL OF NEUROSCIENCE. 2011;31(19):7049-7059
Critical Role of Astroglial Apolipoprotein E and Liver X Receptor-α Expression for Microglial Aβ Phagocytosis
Terwel D; Steffensen KR; Verghese PB; Kummer MP; Gustafsson J-A; Holtzman DM; Heneka MT
Article: JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 2010;69(6):593-605
Neuropathologic and Biochemical Changes During Disease Progression in Liver X Receptor β^-/- Mice, A Model of Adult Neuron Disease
Bigini P; Steffensen KR; Ferrario A; Diomede L; Ferrara G; Barbera S; Salzano S; Fumagalli E; Ghezzi P; Mennini T; Gustafsson J-A
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1801(4):421-429
ADD1/SREBP1c activates the PGC1-α promoter in brown adipocytes
Hao Q; Hansen JB; Petersen RK; Hallenborg P; Jorgensen C; Cinti S; Larsen PJ; Steffensen KR; Wang H; Collins S; Wang J; Gustafsson J-A; Madsen L; Kristiansen K
Article: GENES & DEVELOPMENT. 2010;24(4):381-395
GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRβ in the hepatic acute phase response
Venteclef N; Jakobsson T; Ehrlund A; Damdimopoulos A; Mikkonen L; Ellis E; Nilsson L-M; Parini P; Janne OA; Gustafsson J-A; Steffensen KR; Treuter E
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2010;298(2):E167-E178
Separate and overlapping metabolic functions of LXRα and LXRβ in C57Bl/6 female mice
Korach-Andre M; Parini P; Larsson L; Arner A; Steffensen KR; Gustafsson J-A
Article: NATURE MEDICINE. 2010;16(1):98-105
Tumor-mediated liver X receptor-α activation inhibits CC chemokine receptor-7 expression on dendritic cells and dampens antitumor responses
Villablanca EJ; Raccosta L; Zhou D; Fontana R; Maggioni D; Negro A; Sanvito F; Ponzoni M; Valentinis B; Bregni M; Prinetti A; Steffensen KR; Sonnino S; Gustafsson J-A; Doglioni C; Bordignon C; Traversari C; Russo V
Article: SHOCK. 2009;32(5):548-553
LIVER X RECEPTOR AGONIST GW3965 DOSE-DEPENDENTLY REGULATES LPS-MEDIATED LIVER INJURY AND MODULATES POSTTRANSCRIPTIONAL TNF-α PRODUCTION AND P38 MITOGEN-ACTIVATED PROTEIN KINASE ACTIVATION IN LIVER MACROPHAGES
Wang YY; Dahle MK; Steffensen KR; Reinholt FP; Collins JL; Thiemermann C; Aasen AO; Gustafsson J-A; Wang JE
Article: CELL STEM CELL. 2009;5(4):409-419
Liver X Receptors and Oxysterols Promote Ventral Midbrain Neurogenesis In Vivo and in Human Embryonic Stem Cells
Sacchetti P; Sousa KM; Hall AC; Liste I; Steffensen KR; Theofilopoulos S; Parish CL; Hazenberg C; Ahrlund-Richter L; Hovatta O; Gustafsson J-A; Arenas E
Article: PLOS ONE. 2009;4(9):e7266
Susceptibility of pancreatic beta cells to fatty acids is regulated by LXR/PPARalpha-dependent stearoyl-coenzyme A desaturase.
Hellemans KH; Hannaert J-C; Denys B; Steffensen KR; Raemdonck C; Martens GA; Van Veldhoven PP; Gustafsson J-A; Pipeleers D
Article: ENDOCRINOLOGY. 2009;150(9):4104-4113
Activation of Liver X Receptor Regulates Substrate Oxidation in White Adipocytes
Stenson BM; Ryden M; Steffensen KR; Wahlen K; Pettersson AT; Jocken JW; Arner P; Laurencikiene J
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(6):1626-1637
Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice
Korf H; Vander Beken S; Romano M; Steffensen KR; Stijlemans B; Gustafsson J-A; Grooten J; Huygen K
Article: MOLECULAR CELL. 2009;34(4):510-518
GPS2 Is Required for Cholesterol Efflux by Triggering Histone Demethylation, LXR Recruitment, and Coregulator Assembly at the ABCG1 Locus
Jakobsson T; Venteclef N; Toresson G; Damdimopoulos AE; Ehrlund A; Lou X; Sanyal S; Steffensen KR; Gustafsson J-A; Treuter E
Article: MOLECULAR AND CELLULAR BIOLOGY. 2009;29(8):2230-2242
E3 Ubiquitin Ligase RNF31 Cooperates with DAX-1 in Transcriptional Repression of Steroidogenesis
Ehrlund A; Anthonisen EH; Gustafsson N; Venteclef N; Remen KR; Damdimopoulos AE; Galeeva A; Pelto-Huikko M; Lalli E; Steffensen KR; Gustafsson J-A; Treuter E
Article: CARCINOGENESIS. 2009;30(4):575-579
The oxysterol receptor LXR inhibits proliferation of human breast cancer cells
Vedin L-L; Lewandowski SA; Parini P; Gustafsson J-A; Steffensen KR
Article: BMC MEDICAL GENETICS. 2009;10:27
Functional and genetic analysis in type 2 diabetes of Liver X receptor alleles - a cohort study
Dahlman I; Nilsson M; Gu HF; Lecoeur C; Efendic S; Ostenson CG; Brismar K; Gustafsson J-A; Froguel P; Vaxillaire M; Dahlman-Wright K; Steffensen KR
Article: PHARMACOGENETICS AND GENOMICS. 2008;18(11):967-975
Estrogen receptor alpha gene variants associate with type 2 diabetes and fasting plasma glucose
Dahlman I; Vaxillaire M; Nilsson M; Lecoeur C; Gu HF; Cavalcanti-Proenca C; Efendic S; Ostenson CG; Brismar K; Charpentler G; Gustafsson J-A; Froguel P; Dahlman-Wright K; Steffensen KR
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(33):22723-22736
Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes
Madsen L; Petersen RK; Steffensen KR; Pedersen LM; Hallenborg P; Ma T; Froyland L; Doskeland SO; Gustafsson J-A; Kristiansen K
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_14):t462
P2‐306: Activation of both LXRα and LXRβ is required for TO901317‐mediated lowering of Aβ42: implications for the development of Alzheimer's therapeutics
Riddell DR; Li Z; Zhou H; Aschmies S; Kouranova E; Ring R; Warwick HW; Gustafsson JA; Steffensen KR; Pangalos MN; Jacobsen SJ; Reinhart PH
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2008;283(14):8995-9001
RAP250 is a coactivator in the transforming growth factor β signaling pathway that interacts with smad2 and smad3
Antonson P; Jakobsson T; Almloef T; Guldevall K; Steffensen KR; Gustafsson J-A
Article: BMC MOLECULAR BIOLOGY. 2007;8:106
Human NCU-GI can function as a transcription factor and as a nuclear receptor co-activator
Steffensen KR; Bouzga M; Skjeldal F; Kasi C; Karahasan A; Matre V; Bakke O; Guerin S; Eskild W
Article: MOLECULAR PHARMACOLOGY. 2007;72(4):947-955
Physiological differences between human and rat primary hepatocytes in response to liver X receptor activation by 3-[3-[N-(2-chloro-3-trifluoromethylbenzyl)-(2,2diphenylethyl)amino]propyloxy] phenylacetic acid hydrochloride (GW3965)
Kotokorpi P; Ellis E; Parini P; Nilsson L-M; Strom S; Steffensen KR; Gustafsson J-A; Mode A
Article: NUCLEIC ACIDS RESEARCH. 2007;35(14):4858-4868
Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter
Nilsson M; Dahlman-Wright K; Karelmo C; Gustafsson J-A; Steffensen KR
Article: MOLECULAR ENDOCRINOLOGY. 2007;21(1):126-137
Liver X receptors regulate adrenal steroidogenesis and hypothalamic-pituitary-adrenal feedback
Nilsson M; Stulnig TM; Lin C-Y; Yeo AL; Nowotny P; Liu ET; Steffensen KR
Article: MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2006;256(1-2):9-16
Reduced fertility and inability of oocytes to resume meiosis in mice deficient of the Lxr genes
Steffensen KR; Robertson K; Gustafsson J-A; Andersen CY
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2006;317(1):395-401
Pitavastatin effect on ATP binding cassette A1-mediated lipid efflux from macrophages:: Evidence for liver X receptor (LXR)-dependent and LXR-independent mechanisms of activation by cAMP
Zanotti I; Potì F; Favari E; Steffensen KR; Gustafsson J; Bernini F
Article: JOURNAL OF NEUROIMMUNOLOGY. 2006;172(1-2):137-144
CD24 and myosin light polypeptide 2 are involved in prevention of experimental autoimmune encephalomyelitis by myelin basic protein-pulsed dendritic cells
Liu X; Lindberg R; Xiao BG; Steffensen KR; Leppert D; Link H; Huang YM
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2005;338(2):981-986
Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors
Grempler R; Günther S; Steffensen KR; Nilsson M; Barthel A; Schmoll D; Walther R
Article: NEUROBIOLOGY OF DISEASE. 2005;20(3):961-968
Anti-inflammatory nuclear receptor superfamily in multiple sclerosis patients from Sardinia and Sweden
Liu XA; Steffensen KR; Sanna A; Arru G; Fois ML; Rosati G; Sotgiu S; Link H; Gustafsson J; Huang YM
Article: MULTIPLE SCLEROSIS JOURNAL. 2005;11(4):381-389
Autoantigen-pulsed dendritic cells constitute a beneficial cytokine and growth factor network in ameliorating experimental allergic encephalomyelitis
Liu X; Ciumas C; Huang YM; Steffensen KR; Lian H; Link H; Xiao BG
Article: JOURNAL OF CLINICAL INVESTIGATION. 2005;115(7):1913-1922
Liver X receptors α and β regulate renin expression in vivo
Morello F; de Boer RA; Steffensen KR; Gnecchi M; Chisholm JW; Boomsma F; Anderson LM; Lawn RM; Gustafsson J; Lopez-Ilasaca M; Pratt RE; Dzau VJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(24):23024-23031
LXRβ is required for adipocyte growth, glucose homeostasis, and β cell function
Gerin I; Dolinsky VW; Shackman JG; Kennedy RT; Chiang SH; Burant CF; Steffensen KR; Gustafsson J; MacDougald OA
Article: ENDOCRINOLOGY. 2005;146(6):2519-2530
The liver X receptor-β is essential for maintaining cholesterol homeostasis in the testis
Robertson KM; Schuster GU; Steffensen KR; Hovatta O; Meaney S; Hultenby K; Johansson LC; Svechnikov K; Söder O; Gustafsson J
Article: MULTIPLE SCLEROSIS JOURNAL. 2005;11(1):16-23
Immunological heterogeneity of multiple sclerosis in Sardinia and Sweden
Huang YM; Liu X; Steffensen K; Sanna A; Arru G; Fois ML; Rosati G; Sotgiu S; Link H
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2004;33(3):609-622
Genome-wide expression profiling;: a panel of mouse tissues discloses novel biological functions of liver X receptors in adrenals
Steffensen KR; Neo SY; Stulnig TM; Vega VB; Rahman SS; Schuster GU; Gustafsson J; Liu ET
Article: MOLECULAR PHARMACOLOGY. 2004;66(6):1440-1452
Overlapping transcriptional programs regulated by the nuclear receptors peroxisome proliferator-activated receptor α, retinoid X receptor, and liver X receptor in mouse liver
Anderson SP; Dunn C; Laughter A; Yoon L; Swanson C; Stulnig TM; Steffensen KR; Chandraratna RAS; Gustafsson J; Corton JC
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(44):46204-46212
Mimetics of caloric restriction include agonists of lipid-activated nuclear receptors
Corton JC; Apte U; Anderson SP; Limaye P; Yoon L; Latendresse J; Dunn C; Everitt JI; Voss KA; Swanson C; Kimbrough C; Wong JS; Gill SS; Chandraratna RAS; Kwak MK; Kensler TW; Stulnig TM; Steffensen KR; Gustafsson J; Mehendale HM
Article: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2004;32(3):879-892
Gene expression profiling identifies liver X receptor alpha as an estrogen-regulated gene in mouse adipose tissue
Lundholm L; Movérare S; Steffensen KR; Nilsson M; Otsuki M; Ohlsson C; Gustafsson J; Dahlman-Wright K
Article: EMBO REPORTS. 2004;5(6):613-619
Functional conservation of interactions between a homeodomain cofactor and a mammalian FTZ-F1 homologue
Steffensen KR; Holter E; Båvner A; Nilsson M; Pelto-Huikko M; Tomarev S; Treuter E
Article: PROTEIN EXPRESSION AND PURIFICATION. 2004;35(2):190-198
Purification of functional full-length liver X receptor β produced in Escherichia coli
Toresson G; Schuster GU; Steffensen KR; Bengtsson M; Ljunggren J; Dahlman-Wright K; Gustafsson J
Article: MOLECULAR AND CELLULAR BIOLOGY. 2004;24(8):3430-3444
Activated liver X receptors stimulate adipocyte differentiation through induction of peroxisome proliferator-activated receptor γ expression
Seo JB; Moon HM; Kim WS; Lee YS; Jeong HW; Yoo EJ; Ham JY; Kang HJ; Park MG; Steffensen KR; Stulnig TM; Gustafsson J; Dai Park S; Kim JB
Journal article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2004;59(6):611
Anti‐Inflammatory Liver X Receptors and Related Molecules in Multiple Sclerosis Patients from Sardinia and Sweden
Huang Y; Liu X; Steffensen K; Sanna A; Arru G; Sominanda A; Sotgiu S; Rosati G; Gustafsson J; Link H
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;312(3):716-724
Glucocorticoid response and promoter occupancy of the mouse LXRα gene
Steffensen KR; Holter E; Alikhani N; Eskild W; Gustafsson J
Article: CARCINOGENESIS. 2003;24(11):1717-1722
Activation of PPAR γ in colon tumor cell lines by oxidized metabolites of linoleic acid, endogenous ligands for PPAR γ
Bull AW; Steffensen KR; Leers J; Rafter JJ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;310(2):589-593
Gene expression profiling in adipose tissue indicates different transcriptional mechanisms of liver X receptors α and β, respectively
Steffensen KR; Nilsson M; Schuster GU; Stulnig TM; Dahlman-Wright K; Gustafsson J
Article: GENE EXPRESSION PATTERNS. 2003;3(2):203-211
TACC3 expression is tightly regulated during early differentiation
Sadek CM; Pelto-Huikko M; Tujague M; Steffensen KR; Wennerholm M; Gustafsson J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(51):49761-49766
Glucocorticoid signaling is perturbed by the atypical orphan receptor and corepressor SHP
Borgius LJ; Steffensen KR; Gustafsson J; Treuter E
Article: MOLECULAR PHARMACOLOGY. 2002;62(6):1299-1305
Novel roles of liver X receptors exposed by gene expression profiling in liver and adipose tissue
Stulnig TM; Steffensen KR; Gao H; Reimers M; Dahlman-Wright K; Schuster GU; Gustafsson J
Article: CIRCULATION. 2002;106(9):1147-1153
Accumulation of foam cells in liver X receptor-deficient mice
Schuster GU; Parini P; Wang L; Alberti S; Steffensen KR; Hansson GK; Angelin B; Gustafsson J
Article: DIABETES. 2002;51(8):2426-2433
Liver X receptors downregulate 11β-hydroxysteroid dehydrogenase type 1 expression and activity
Stulnig TM; Oppermann U; Steffensen KR; Schuster GU; Gustafsson J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2002;293(5):1333-1340
Different regulation of the LXRα promoter activity by isoforms of CCAAT/enhancer-binding proteins
Steffensen KR; Schuster GU; Parini P; Holter E; Sadek CM; Cassel T; Eskild W; Gustafsson J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2001;289(5):1262-1267
Members of the nuclear factor 1 family reduce the transcriptional potential of the nuclear receptor LXRα promoter
Steffensen KR; Holter E; Tobin KAR; Leclerc S; Gustafsson J; Guérin SL; Eskild W
Article: GENE. 2000;243(1-2):93-103
Structural characterisation of the mouse nuclear oxysterol receptor genes LXRα and LXRβ
Alberti S; Steffensen KR; Gustafsson J
Article: MOLECULAR ENDOCRINOLOGY. 1999;13(7):1105-1118
Ligand-independent coregulator recruitment by the triply activatable OR1/retinoid X receptor-α nuclear receptor heterodimer
Wiebel FF; Steffensen KR; Treuter E; Feltkamp D; Gustafsson J
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Meeting abstract: ATHEROSCLEROSIS. 2019;287:E28-E29
REDUCTION OF BILE ACID SYNTHESIS AND INTRAHEPATIC LIPID ACCUMULATION IN LIVER-HUMANIZED MICE DEFINE THE UNFAVORABLE PHARMACODYNAMICS OF LXR AGONISM IN HUMANS
Minniti ME; Vedin LL; Pedrelli M; Oorni K; Luquet SH; Wilson EM; Bial J; Steffensen KR; Parini P
Meeting abstract: ATHEROSCLEROSIS. 2018;275:E25
GENETIC DEPLETION OF THE SOAT2 GENE DIMINISHES DIET-INDUCED HEPATIC STEATOSIS AND IMPROVES GLUCOSE TOLERANCE IN MICE
Pramfalk C; Ahmed O; Larsson L; Hardfeldt J; Pedrelli M; Vedin L; Steffensen K; Tellez M; Delbes A; Denis R; Luquet S; Eriksson M; Parini P
Meeting abstract: ATHEROSCLEROSIS. 2017;263:E7
LIVER-HUMANIZED MICE EXHIBIT LIPOPROTEIN-SPECIFIC PHENOTYPES WHEN GRAFTED WITH HUMAN HEPATOCYTES FROM DIFFERENT DONORS
Minniti ME; Vedin L-L; Wilson EM; Steffensen KR; Parini P
Preprint: BIORXIV. 2017
Changes in LXRα phosphorylation promote a novel diet-induced transcriptome that alters the transition from fatty liver to steatohepatitis
Becares N; Gage MC; Martin-Gutierrez L; Shrestha E; Louie R; Pourcet B; Pello OM; Luong TV; Goñi S; Liang N; Pichardo C; Røberg-Larsen H; Diaz V; Steffensen KR; Garabedian MJ; Rombouts K; Treuter E; Pineda-Torra I
Review: ACTA PHYSIOLOGICA. 2016;217(3):184-216
Emerging role of thyroid hormone metabolites
Gnocchi D; Steffensen KR; Bruscalupi G; Parini P
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2016;20(1):61-71
The emerging roles of liver X receptors and their ligands in cancer
Lin C-Y; Vedin L-L; Steffensen KR
Conference publication: EUROPEAN JOURNAL OF HEART FAILURE. 2016;18:431
Mouse cardiac LXRalpha overexpression as a model to modulate cardiac metabolism and trigger specific fetal gene expression to ameliorate pathological hypertrophy
De Boer RAR; Cannon MV; Sijbesma JWA; Vreeswijk-Baudoin I; De Windt LJ; Khan MAF; Steffensen KR; Sillje HH; Van Gilst WH
Conference publication: GLIA. 2015;63:E395-E396
Liver X receptor beta deficiency decreases neuroinflammation in an animal model of multiple sclerosis
Vanmol J; Vanmierlo T; Bogie J; Timmermans S; Nelissen K; Wouters K; de Vries H; Gustafsson J-A; Steffensen K; Stinissen P; Hellings N; Hendriks J
Conference publication: GLIA. 2015;63:E66-E67
LXRbeta deficiency attenuates neuroinflammation
Vanmierlo T; Vanmol J; Bogie J; Timmermans S; Nelissen K; Wouters K; -Gustafsson J; Steffensen K; Stinissen P; Hellings N; Hendriks J
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2013;17(8):977-990
Targeting liver X receptors in inflammation
Steffensen KR; Jakobsson T; Gustafsson J-A
Meeting abstract: CANCER RESEARCH. 2013;73(8):1310
Liver X receptor agonist blocks pancreatic cancer cell proliferation.
Candelaria NR; Manchem S; Vu HT; Zheng J; Gabbi C; Dey P; Karaboga H; Lin J; Vedin L-L; Su F; Liu K; Jonsson P; Steffensen KR; Gustafsson J-A; Lin C-Y
Conference publication: CANCER RESEARCH. 2013;73(8):lb-346-lb-346
The Oxysterol-CXCR2 axis plays a key role in the recruitment of tumor promoting neutrophils
Russo V; Raccosta L; Fontana R; Maggioni D; Lanterna C; Paniccia A; Musumeci A; Doglioni C; Leiva A; Villablanca EJ; Mora R; Chiricozzi E; Ciampa MG; Mauri L; Prinetti A; Sonino S; Trincavelli ML; Daniele S; Martini C; Steffensen K; Gustafsson J-A; Feo SG; Bordignon C; Traversari C; Sozzani S
Published conference paper: MOLECULAR MEMBRANE BIOLOGY. 2012;29(7):299-308
Influence of liver-X-receptor on tissue cholesterol, coenzyme Q and dolichol content
Bentinger M; Tekle M; Dallner G; Brismar K; Gustafsson J-A; Steffensen KR; Catrina S-B
Review: TRENDS IN PHARMACOLOGICAL SCIENCES. 2012;33(7):394-404
Liver X receptor biology and pharmacology: new pathways, challenges and opportunities
Jakobsson T; Treuter E; Gustafsson J-A; Steffensen KR
Review: TRENDS IN ENDOCRINOLOGY AND METABOLISM. 2011;22(8):333-343
Metabolic nuclear receptor signaling and the inflammatory acute phase response
Venteclef N; Jakobsson T; Steffensen KR; Treuter E
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):95
ROLES OF LXRα AND LXRβ IN THE REGULATION OF INTESINAL CHOLESTEROL ABSORPTION: DISTINCTIVE EFFECTS ON BILE ACID METABOLISM IN MICE
Hu X; Steffensen K; Jiang Z-Y; Parini P; Gustafsson J-A; Gafvels M; Eggertsen G
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):39
THE INHIBITION OF HEPATIC ACYL COENZYME A:CHOLESTEROL ACYLTRANSFERASE (ACAT) 2 POSITIVELY AFFECTS HDL METABOLISM AND FUNCTIONALITY IN MICE
Pedrelli M; Davoodpour P; Degirolamo C; Gomaraschi M; Larsson L; Rudel LL; Calabresi L; Gustafsson JA; Steffensen K; Eriksson M; Parini P
Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(11):E191
HDL Metabolism and Hepatic Acyl Coenzyme A: Cholesterol Acyltransferase (ACAT) 2 Inhibition in Mice
Pedrelli M; Davoodpour P; Degirolamo C; Gomaraschi M; Larsson L; Rudel LL; Calabresi L; Gustafsson JA; Steffensen K; Eriksson M; Parini P
Conference publication: DIABETOLOGIA. 2010;53
Wound healing is selectively modulated by estrogen receptors in diabetes
Sunkari VG; Grunler J; Lindberg S; Botusan IR; Savu O; Steffensen KR; Brismar K; Catrina S-B
Conference publication: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(11):E281-E282
Liver X Receptor Beta: A Nuclear Receptor Promoting Intestinal Cholesterol Absorption and Influencing Bile Acid Composition in Mice
Hu X-L; Steffensen K; Jiang Z-Y; Parini P; Gustafsson J-A; Gafvels M; Eggertsen G
Meeting abstract: JOURNAL OF HEPATOLOGY. 2009;50:S259
DIET INDUCED FATTY LIVER IS PREVENTED AND REVERSED BY FATTY ACID BILE ACID CONJUGATES (FABACS) VIA INHIBITION OF STEAROYL COENZYME A DESATURASE 1 IN RODENTS
Gilat T; Steffensen KR; Leikin-Frenkel A; Guldevall K; Goldiner I; Konikoff FM
Conference publication: DIABETOLOGIA. 2009;52:S443
Estrogen receptor beta modulates wound healing in diabetes
Sunkari VG; Grunler J; Lindberg S; Savu O; Botusan I; Brismar K; Steffensen KR; Catrina S-B
Corrigendum: NUCLEIC ACIDS RESEARCH. 2008;36(1):352
Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter (vol 35, pg 4858, 2007)
Nilsson M; Dahlman-Wright K; Karelmo C; Ebeling M; Gustafsson J-A; Steffensen KR
Conference publication: SHOCK. 2008;29:101
Role of liver X receptor in experimental sepsis
Wang JE; Wang YY; Dahle MK; Sandvik A; Steffensen KR; Thiemermann C; Chaudry IH; Gustafsson J-A; Aasen AO
Conference publication: HYPERTENSION. 2008;52(4):E88
Nuclear hormone receptor LXR-α inhibits adipocyte differentiation of murine mesenchymal stem cells through Wnt/beta-catenin signaling:: Potential role in the modulation of obesity
Matsushita K; Morello F; Zhang Z; Steffensen KR; Gustafsson JA; Pratt RE; Dzau VJ
Review: CLINICAL LIPIDOLOGY. 2006;1(2):181-189
Liver X receptors: new drug targets to treat Type 2 diabetes?
Steffensen KR; Gustafsson J-A
Book chapter: NEW TRANSCRIPTION FACTORS AND THEIR ROLE IN DIABETES AND ITS THERAPY: ADVANCES IN MOLECULAR AND CELLULAR ENDOCRINOLOGY. 2006;p. 63-312
Chapter 4 Liver X receptors as potential drug targets for diabetes and its disorders
Steffensen KR
Conference publication: DIABETOLOGIA. 2005;48:A208
Evidence for an indirect transcriptional regulation of glucose-6-phosphatase gene expression by liver X receptors
Grempler R; Günther S; Steffensen KR; Nilsson M; Schmoll D; Walther R
Conference publication: IMMUNOLOGY. 2005;116:40
Cross-culture studies in multiple sclerosis (MS): heterogeneity of immune response (IR) variables and nuclear hormone receptor (NHRs) in Sardinia (Sa) and Sweden (Sw)
Link H; Steffensen K; Liu X; Sanna A; Arru G; Gustafsson JA; Huang YM
Published conference paper: DIABETES. 2004;53:S36-S42
Putative metabolic effects of the liver x receptor (LXR)
Steffensen KR; Gustafsson J
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2004;10(7032):S202
Anti-inflammatory liver x receptors and related molecules in multiple sclerosis patients from Sardinia and Sweden
Link H; Liu X; Steffensen K; Sanna A; Arru G; Sominanda A; Sotgiu S; Rosati G; Gustafsson JA; Huang YM
Conference publication: MULTIPLE SCLEROSIS JOURNAL. 2004;10(7032):S200
Autoantigen-pulsed dendritic cells constitute a protective cytokine and growth factor network in spinal cord against marine EAE
Link H; Liu X; Ciumas C; Huang YM; Steffensen KR; Xiao BG
Conference publication: JOURNAL OF NEUROIMMUNOLOGY. 2004;154(1-2):37
Cytokine expression patterns in multiple sclerosis patients from Sardinia and Stockholm
Link H; Liu X; Steffensen K; Sanna A; Arru G; Fois ML; Rosati G; Sotgiu S; Gustafsson J; Huang YM
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Forskningsbidrag

Biological and Pathological Significance of Liver X Receptors
Swedish Research Council
1 January 2013 - 31 December 2015
Understanding the biology of genes associated with longevity and healthy aging using humanised mouse models
Swedish Research Council
1 January 2013 - 31 December 2016
Biological and pathological significance of Liver X Receptors
Swedish Research Council
1 January 2011 - 31 December 2012
The oxysterol receptors LXRs in pathophysiology and molecular mechanisms of metabolic disorders and cancer
Swedish Research Council
1 January 2009 - 31 December 2012
The oxysterol receptors LXRs in pathophysiology and molecular mechanisms of metabolic disorders and cancer
Swedish Research Council
1 January 2009 - 31 December 2012

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