Kjell Larsson
Professor Emeritus/Emerita
E-postadress: kjell.larsson@ki.se
Telefon: +46852487489
Besöksadress: Nobels väg 13, 17177 STOCKHOLM
Postadress: C6 Institutet för miljömedicin, C6 Integrativ toxikologi Palmberg, 171 77 Stockholm
Om mig
- Luftvägsinflammation orsakad av luftburen exponering.
Forskningsbeskrivning
- I flera delprojekt studeras inflammatoriska tillstånd i lungor och luftvägar. Kroniskt obstruktiv lungsjukdom (KOL) orsakas företrädesvis av tobaksrökning och samvarierar i hög utsträckning med andra sjukdomstillstånd. Vid KOL noteras även ett betydande systemiskt engagemang. En viktig forskningslinje är att karakterisera systemisk inflammation och inflammation i luftvägar vid KOL och att relatera dessa fynd till kliniska utfallsvariabler som lungfunktion, livskvalitet, förekomst av emfysem, fysisk prestationsförmåga, tandlossning, hjärtsjukdom etc.
I en annan forskningslinje karakteriseras luftvägsinflammation och påverkan på lungfunktion och systemengagemang vid exponering för organiskt damm. Inhalation av lantbruksdamm från svingårdar leder till en synnerligen kraftig luftvägsinflammation samt en ökning av direkt bronkiell reaktivitet. I exponeringsstudier av friska försökspersoner och lantbrukare bedöms inflammatoriska parametrar med huvudvikt på neutrofil granulocytfunktion och icke-förvärvat immunsvar i blod, upphostningsprov, sköljvätska från bronkoskopier. Våra tidigare studier har visat att lantbrukare har ett nedsatta inflammatoriska och fysiologiska svar mot akut exponering i svinhus vilket sannolikt tyder på någon form av immunologisk och fysiologisk toleransutveckling till följd av långvarig kontinuerlig exponering.
Finansiering:
Hjärt-Lungfonden
Stockholms Läns Landsting
Fem utvalda publikationer:
1. Nathell L, Nathell M, Malmberg P, Larsson K.
COPD diagnosis related to different guidelines and spirometry techniques. Respir Res. 2007 Dec 4 - 8(1):89.
2. Strandberg K, Ek A, Palmberg L, Larsson K.
Fluticasone and ibuprofen do not add to the effect of salmeterol on organic dust-induced airway inflammation and bronchial hyper-responsiveness. Journal of internal medicine. 2008 Jul - 264(1):83-94.
3. Dahlen B, Lantz AS, Ihre E, Skedinger M, Henriksson E, Jorgensen L, Ekström T, Dahlén S-E, Larsson K
Effect of formoterol with or without budesonide in repeated low-dose allergen challenge. Eur Respir J. 2009 - 33:747-53.
4. Stallberg B, Selroos O, Vogelmeier C, Andersson E, Ekstrom T, Larsson K.
Budesonide/formoterol as effective as prednisolone plus formoterol in acute exacerbations of COPD: a double-blind, randomised, non-inferiority, parallel-group, multicentre study. Respir Res. 2009 Feb 19 - 10(1):11.
5. Sundblad BM, von Scheele I, Palmberg L, Olsson M, Larsson K.
Repeated exposure to organic material alters inflammatory and physiological airway responses. Eur Respir J. 2009 Feb 12 - 34:80-8.
Artiklar
- Article: LAKARTIDNINGEN. 2022;119:21155
- Article: RESPIRATORY MEDICINE. 2021;185:106483
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(7):883-891
- Article: EUROPEAN RESPIRATORY JOURNAL. 2021;57(2):2000515
- Article: INTERNATIONAL JOURNAL OF COPD. 2021;16:909-918
- Article: INTERNATIONAL JOURNAL OF COPD. 2021;16:701-713
- Article: INTERNATIONAL JOURNAL OF COPD. 2021;16:677-688
- Article: LAKARTIDNINGEN. 2020;117:20051
- Article: NPJ PRIMARY CARE RESPIRATORY MEDICINE. 2020;30(1):47
- Article: CLINICAL SCIENCE. 2020;134(10):1107-1125
- Article: INTERNATIONAL JOURNAL OF COPD. 2020;15:235-245
- Article: NPJ PRIMARY CARE RESPIRATORY MEDICINE. 2019;29(1):45
- Article: SCIENTIFIC REPORTS. 2019;9(1):13101
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2019;317(3):L305-L316
- Article: INTERNATIONAL JOURNAL OF COPD. 2019;14:995-1008
- Article: DISEASE MARKERS. 2018;2018:4949175-11
- Article: NPJ PRIMARY CARE RESPIRATORY MEDICINE. 2018;28(1):33
- Article: RESPIRATORY RESEARCH. 2018;19(1):172
- Article: RESPIRATORY RESEARCH. 2018;19(1):168
- Article: EUROPEAN RESPIRATORY JOURNAL. 2018;52(2):1701927
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY: IN PRACTICE. 2018;6(3):916-922.e6
- Article: RESPIRATORY MEDICINE. 2018;136:15-20
- Article: PULMONARY PHARMACOLOGY AND THERAPEUTICS. 2018;48:203-210
- Article: RESPIRATORY RESEARCH. 2018;19(1):12
- Article: INTERNATIONAL JOURNAL OF COPD. 2018;13:3611-3624
- Article: INTERNATIONAL JOURNAL OF COPD. 2018;13:1833-1839
- Article: INTERNATIONAL JOURNAL OF COPD. 2018;13:275-285
- Article: EUROPEAN CLINICAL RESPIRATORY JOURNAL. 2017;4(1):1290193
- Article: EUROPEAN CLINICAL RESPIRATORY JOURNAL. 2017;4(1):1270079
- Article: PLOS ONE. 2017;12(3):e0173132
- Article: RESPIRATORY RESEARCH. 2016;17(1):152
- Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2016;73(10):648-655
- Article: RESPIRATORY MEDICINE. 2016;117:81-91
- Article: EUROPEAN RESPIRATORY JOURNAL. 2016;47(6):1645-1656
- Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2016;310(2):L155-L165
- Article: INTERNATIONAL JOURNAL OF COPD. 2016;11:2109-2116
- Article: INTERNATIONAL JOURNAL OF COPD. 2016;11:1035-1043
- Article: INTERNATIONAL JOURNAL OF COPD. 2016;11:1005-1013
- Article: RESPIRATORY MEDICINE. 2015;109(9):1164-1173
- Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(3):272-279
- Article: BMC PULMONARY MEDICINE. 2015;15:26
- Article: RESPIRATORY MEDICINE. 2015;109(3):312-319
- Article: EUROPEAN CLINICAL RESPIRATORY JOURNAL. 2015;2:27915
- Article: EUROPEAN CLINICAL RESPIRATORY JOURNAL. 2015;2:27023
- Article: INTERNATIONAL JOURNAL OF COPD. 2015;10:2327-2334
- Article: INTERNATIONAL JOURNAL OF COPD. 2015;10:173-183
- Article: COPD: JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. 2014;11(5):575-581
- Article: RESPIRATORY MEDICINE. 2014;108(9):1345-1354
- Article: RESPIRATORY RESEARCH. 2014;15(1):104
- Article: PRIMARY CARE RESPIRATORY JOURNAL. 2014;23(1):38-45
- Article: THORAX. 2014;69(2):130-136
- Article: EUROPEAN CLINICAL RESPIRATORY JOURNAL. 2014;1:24545
- Article: PLOS ONE. 2014;9(8):e104755
- Article: RESPIRATORY MEDICINE. 2013;107(11):1651-1658
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2013;68(10):1314-1321
- Article: JOURNAL OF INTERNAL MEDICINE. 2013;273(6):584-594
- Article: RESPIRATORY RESEARCH. 2013;14(1):47
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2013;68(3):347-354
- Article: PLOS ONE. 2013;8(3):e59492
- Article: PLOS ONE. 2013;8(12):e84110
- Article: PLOS ONE. 2013;8(1):e54137
- Article: RESPIROLOGY. 2012;17(5):854-860
- Article: INNATE IMMUNITY. 2012;18(3):503-510
- Article: JOURNAL OF ADVANCED NURSING. 2012;68(4):767-782
- Article: PLOS ONE. 2012;7(2):e31646
- Article: LAKARTIDNINGEN. 2011;108(35):1604-1605
- Article: RESPIRATORY MEDICINE. 2011;105(8):1222-1230
- Article: PULMONARY PHARMACOLOGY AND THERAPEUTICS. 2010;23(4):316-323
- Article: SCANDINAVIAN JOURNAL OF MEDICINE AND SCIENCE IN SPORTS. 2010;20(4):644-650
- Article: THE CLINICAL RESPIRATORY JOURNAL. 2010;4(3):147-156
- Article: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. 2010;14(6):764-771
- Article: INHALATION TOXICOLOGY. 2010;22(6):493-499
- Article: RESPIRATORY MEDICINE. 2010;104(3):404-411
- Article: JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2010;52(2):214-218
- Article: INNATE IMMUNITY. 2010;16(1):27-38
- Article: THE CLINICAL RESPIRATORY JOURNAL. 2010;4(1):51-58
- Article: NICOTINE AND TOBACCO RESEARCH. 2010;12(1):37-42
- Article: PATIENT EDUCATION AND COUNSELING. 2009;77(2):209-217
- Article: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 2009;35(5):376-383
- Article: EUROPEAN RESPIRATORY JOURNAL. 2009;34(1):80-88
- Article: EUROPEAN RESPIRATORY JOURNAL. 2009;33(4):747-753
- Article: RESPIRATORY RESEARCH. 2009;10(1):11
- Article: RESPIRATORY MEDICINE. 2008;102(12):1730-1736
- Article: JOURNAL OF INTERNAL MEDICINE. 2008;264(1):83-94
- Article: NICOTINE AND TOBACCO RESEARCH. 2008;10(5):883-890
- Article: JOURNAL OF ASTHMA. 2008;45(3):201-203
- Article: THE CLINICAL RESPIRATORY JOURNAL. 2008;2(1):11-16
- Article: RESPIRATORY MEDICINE. 2007;101(6):1132-1139
- Article: RESPIRATORY MEDICINE. 2007;101(6):1196-1204
- Article: LIFE SCIENCES. 2007;80(17):1598-1607
- Article: COPD: JOURNAL OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE. 2007;4(1):5-13
- Article: EUROPEAN RESPIRATORY JOURNAL. 2006;28(6):1229-1235
- Article: RESPIRATORY RESEARCH. 2006;7(1):127
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2006;118(1):78-83
- Article: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 2006;32(2):145-153
- Article: CHEST. 2006;129(3):624-631
- Article: RESPIRATORY MEDICINE. 2006;100(2):226-237
- Article: RESPIRATORY MEDICINE. 2006;100(1):130-139
- Article: LAKARTIDNINGEN. 2005;102(44):3246-3247
- Article: CHEST. 2005;128(4):3038-3047
- Article: INFLAMMATION RESEARCH. 2005;54(7):281-288
- Article: RESPIRATORY RESEARCH. 2005;6(1):44
- Article: CHEST. 2005;127(5):1714-1721
- Article: INFLAMMATION. 2005;29(1):39-45
- Article: LIFE SCIENCES. 2004;75(23):2733-2749
- Article: EUROPEAN RESPIRATORY JOURNAL. 2004;24(4):587-593
- Article: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 2004;30(4):313-321
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;113(6):1172-1177
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2004;59(6):661-667
- Article: PRIMARY CARE RESPIRATORY JOURNAL. 2004;13(1):42-47
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2003;33(10):1342-1348
- Article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 2003;60(8):e1
- Article: RESPIRATORY MEDICINE. 2003;97(8):882-892
- Article: INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH. 2003;62(2):142-157
- Article: EUROPEAN RESPIRATORY JOURNAL. 2003;21(4):672-676
- Article: RESPIRATORY MEDICINE. 2003;97(2):115-122
- Article: RESPIRATORY MEDICINE. 2003;97(1):46-50
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2002;32(12):1776-1781
- Article: INFLAMMATION. 2002;26(6):291-296
- Article: MOLECULAR AND CELLULAR BIOCHEMISTRY. 2002;240(1-2):131-133
- Article: EUROPEAN RESPIRATORY JOURNAL. 2002;20(5):1138-1146
- Article: RESPIRATORY MEDICINE. 2002;96(10):759-769
- Article: EUROPEAN RESPIRATORY JOURNAL. 2002;20(3):686-690
- Article: EUROPEAN RESPIRATORY JOURNAL. 2002;20(2):426-431
- Article: RESPIRATORY MEDICINE. 2002;96(8):642-650
- Article: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 2002;28(4):256-263
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;57(8):687-693
- Article: CHEST. 2002;122(1):363-368
- Article: RESPIRATORY MEDICINE. 2002;96(7):477-481
- Article: LIFE SCIENCES. 2002;71(3):299-309
- Article: LAKARTIDNINGEN. 2002;99(23):2665-2666
- Article: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE. 2002;41(4):250-258
- Article: EUROPEAN RESPIRATORY JOURNAL. 2002;19(3):534-537
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;57(2):164-168
- Article: INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE. 2002;6(1):76-84
- Article: EUROPEAN RESPIRATORY JOURNAL. 2002;19(1):104-107
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(1):6-12
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;121(1):11-16
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2001;21(6):673-681
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2001;31(9):1356-1368
- Article: RESPIRATORY MEDICINE. 2001;95(8):685-692
- Article: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH. 2001;74(4):249-254
- Article: CLINICAL SCIENCE. 2001;100(4):451-457
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2001;163(3):694-698
- Article: RESPIRATORY MEDICINE. 2001;95(1):22-30
- Article: CHEST. 2000;118(5):1371-1377
- Article: RESPIRATORY MEDICINE. 2000;94(11):1065-1072
- Article: RESPIRATORY MEDICINE. 2000;94(8):821-827
- Article: RESPIRATORY MEDICINE. 2000;94(2):139-144
- Article: INDOOR AIR. 1999;9(4):219-225
- Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 1999;54(7):691-699
- Article: INFLAMMATION. 1999;23(3):217-230
- Article: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE. 1999;35(2):142-149
- Article: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 1999;25(1):39-41
- Article: THORAX. 1998;53(12):1041-1046
- Article: EUROPEAN RESPIRATORY JOURNAL. 1998;12(4):825-830
- Article: RESPIRATORY MEDICINE. 1998;92(8):1022-1027
- Article: THORAX. 1998;53(4):260-264
- Article: RESPIRATORY MEDICINE. 1998;92(2):162-166
- Article: JOURNAL OF ASTHMA. 1998;35(7):565-573
- Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1997;210(1):41-49
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 1997;29(12):1631-1636
- Article: THORAX. 1997;52(7):638-642
- Article: EUROPEAN RESPIRATORY JOURNAL. 1997;10(2):381-387
- Article: EUROPEAN RESPIRATORY JOURNAL. 1997;10(2):376-380
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1996;154(5):1261-1266
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1996;26 Suppl 4:18-19
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 1996;26 Suppl 4:8-17
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1996;153(3):948-952
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1996;153(2):576-581
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 1996;153(1):147-152
- Article: EUROPEAN RESPIRATORY JOURNAL. 1995;8(9):1514-1519
- Article: CLINICAL SCIENCE. 1995;88(4):439-446
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Alla övriga publikationer
- Review: BRITISH JOURNAL OF SPORTS MEDICINE. 2022;56(4):213-222
- Review: BMC FAMILY PRACTICE. 2021;22(1):244
- Review: NPJ PRIMARY CARE RESPIRATORY MEDICINE. 2020;30(1):25
- Review: LAKARTIDNINGEN. 2019;116:FF76
- Letter: LAKARTIDNINGEN. 2017;114:ELXS
- Letter: INTERNATIONAL JOURNAL OF COPD. 2017;12:1427
- Review: INTERNATIONAL JOURNAL OF COPD. 2017;12:3055-3064
- Review: EXPERT REVIEW OF RESPIRATORY MEDICINE. 2016;10(3):351-362
- Review: RESPIRATORY MEDICINE. 2013;107(10):1481-1490
- Review: THE CLINICAL RESPIRATORY JOURNAL. 2010;4:35-40
- Editorial comment: THE CLINICAL RESPIRATORY JOURNAL. 2010;4:iii
- Corrigendum: PATIENT EDUCATION AND COUNSELING. 2010;79(2):272
- Published conference paper: THE CLINICAL RESPIRATORY JOURNAL. 2008;2:84-87
- Review: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2008;63(5):492-505
- Review: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2008;63(4):387-403
- Review: RESPIRATORY RESEARCH. 2007;8(1):89
- Review: JOURNAL OF INTERNAL MEDICINE. 2007;262(3):311-340
- Review: LAKARTIDNINGEN. 2007;104(13):1043-1046
- Corrigendum: SCANDINAVIAN JOURNAL OF WORK, ENVIRONMENT & HEALTH. 2007;33(2):160
- Letter: CHEST. 2006;129(1):213-214
- Letter: CRITICAL REVIEWS IN TOXICOLOGY. 2005;35(5):459-460
- Review: LAKARTIDNINGEN. 2005;102(10):766-771
- Review: LAKARTIDNINGEN. 2005;102(9):654-659
- Published conference paper: AMERICAN JOURNAL OF INDUSTRIAL MEDICINE. 2004;46(4):363-370
- Letter: EUROPEAN RESPIRATORY JOURNAL. 2003;22(4):717
- Corrigendum: RESPIRATORY MEDICINE. 2003;97(5):588
- Editorial comment: EUROPEAN RESPIRATORY JOURNAL. 1997;10(11):2441-2442
- Review: LAKARTIDNINGEN. 1997;94(42):3741-3750
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