Jonas Frisén

Article: NATURE NEUROSCIENCE. 2025;28(2):415-430

Multimodal transcriptomics reveal neurogenic aging trajectories and age-related regional inflammation in the dentate gyrus

Wu Y; Korobeynyk VI; Zamboni M; Waern F; Cole JD; Mundt S; Greter M; Frisen J; Llorens-Bobadilla E; Jessberger S

Article: CIRCULATION. 2025;151(3):245-256

A Latent Cardiomyocyte Regeneration Potential in Human Heart Disease

Derks W; Rode J; Collin S; Rost F; Heinke P; Hariharan A; Pickel L; Simonova I; Lazar E; Graham E; Jashari R; Andrae M; Jeppsson A; Salehpour M; Alkass K; Druid H; Kyriakopoulos CP; Taleb I; Shankar TS; Selzman CH; Sadek H; Jovinge S; Brusch L; Frisen J; Drakos S; Bergmann O

Article: GENOME BIOLOGY. 2024;25(1):214

Inferring clonal somatic mutations directed by X chromosome inactivation status in single cells

Demirci I; Larsson AJM; Chen X; Hartman J; Sandberg R; Frisen J

Article: NATURE COMMUNICATIONS. 2024;15(1):3475

High clonal diversity and spatial genetic admixture in early prostate cancer and surrounding normal tissue

Zhang N; Harbers L; Simonetti M; Diekmann C; Verron Q; Berrino E; Bellomo SE; Longo GMC; Ratz M; Schultz N; Tarish F; Su P; Han B; Wang W; Onorato S; Grassini D; Ballarino R; Giordano S; Yang Q; Sapino A; Frisen J; Alkass K; Druid H; Roukos V; Helleday T; Marchio C; Bienko M; Crosetto N

Article: CELL SYSTEMS. 2024;15(2):149-165.e10

Clonally heritable gene expression imparts a layer of diversity within cell types

Mold JE; Weissman MH; Ratz M; Hagemann-Jensen M; Hard J; Eriksson C-J; Toosi H; Berghenstrahle J; Ziegenhain C; von Berlin L; Martin M; Blom K; Lagergren J; Lundeberg J; Sandberg R; Michaeeurolsson J; Frisen J

Article: SCIENCE. 2023;382(6675):eadf8486

Spatial transcriptomics of B cell and T cell receptors reveals lymphocyte clonal dynamics

Engblom C; Thrane K; Lin Q; Andersson A; Toosi H; Chen X; Steiner E; Lu C; Mantovani G; Hagemann-Jensen M; Saarenpaa S; Jangard M; Saez-Rodriguez J; Michaelsson J; Hartman J; Lagergren J; Mold JE; Lundeberg J; Frisen J

Article: BIORXIV. 2023;:2023.09.14.557681

A latent cardiomyocyte regeneration potential in human heart disease.

Derks W; Rode J; Collin S; Rost F; Heinke P; Hariharan A; Pickel L; Simonova I; Lázár E; Graham E; Jashari R; Andrä M; Jeppsson A; Salehpour M; Alkass K; Druid H; Kyriakopoulos CP; Taleb I; Shankar TS; Selzman CH; Sadek H; Jovinge S; Brusch L; Frisén J; Drakos S; Bergmann O

Article: NATURE BIOTECHNOLOGY. 2023;41(8):1085-1088

Solid-phase capture and profiling of open chromatin by spatial ATAC

Llorens-Bobadilla E; Zamboni M; Marklund M; Bhalla N; Chen X; Hartman J; Frisen J; Stahl PL

Article: NATURE COMMUNICATIONS. 2023;14(1):2184

DRAG in situ barcoding reveals an increased number of HSPCs contributing to myelopoiesis with age

Urbanus J; Cosgrove J; Beltman JBB; Elhanati Y; Moral RAA; Conrad C; van Heijst JWW; Tubeuf E; Velds A; Kok L; Merle C; Magnusson JPP; Guyonnet L; Frisen J; Fre S; Walczak AMM; Mora T; Jacobs H; Schumacher TNN; Perie L

Article: HIPPOCAMPUS. 2023;33(4):391-401

Early fate bias in neuroepithelial progenitors of hippocampal neurogenesis

von Berlin L; Westholm JO; Ratz M; Frisen J

Article: DEVELOPMENTAL CELL. 2023;58(3):239-255.e10

An ependymal cell census identifies heterogeneous and ongoing cell maturation in the adult mouse spinal cord that changes dynamically on injury

Albors AR; Singer GA; Llorens-Bobadilla E; Frisen J; May AP; Ponting CP; Storey KG

Article: MOLECULAR ONCOLOGY. 2022;16(19):3452-3464

Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity

Classon J; Zamboni M; Engblom C; Alkass K; Mantovani G; Pou C; Nkulikiyimfura D; Brodin P; Druid H; Mold J; Frisen J

Article: CELL REPORTS. 2022;38(9):110440

Identification of a discrete subpopulation of spinal cord ependymal cells with neural stem cell properties

Stenudd M; Sabelstrom H; Llorens-Bobadilla E; Zamboni M; Blom H; Brismar H; Zhang S; Basak O; Clevers H; Goritz C; Barnabe-Heider F; Frisen J

Article: NATURE NEUROSCIENCE. 2022;25(3):285-294

Clonal relations in the mouse brain revealed by single-cell and spatial transcriptomics

Ratz M; von Berlin L; Larsson L; Martin M; Westholm JO; La Manno G; Lundeberg J; Frisen J

Article: NATURE COMMUNICATIONS. 2021;12(1):6012

Spatial deconvolution of HER2-positive breast cancer delineates tumor-associated cell type interactions

Andersson A; Larsson L; Stenbeck L; Salmen F; Ehinger A; Wu SZ; Al-Eryani G; Roden D; Swarbrick A; Borg A; Frisen J; Engblom C; Lundeberg J

Article: NATURE COMMUNICATIONS. 2021;12(1):5501

Pericyte-derived fibrotic scarring is conserved across diverse central nervous system lesions

Dias DO; Kalkitsas J; Kelahmetoglu Y; Estrada CP; Tatarishvili J; Holl D; Jansson L; Banitalebi S; Amiry-Moghaddam M; Ernst A; Huttner HB; Kokaia Z; Lindvall O; Brundin L; Frisen J; Goritz C

Article: CELL REPORTS. 2021;35(8):109174

Divergent clonal differentiation trajectories establish CD8⁺ memory T cell heterogeneity during acute viral infections in humans

Mold JE; Modolo L; Hard J; Zamboni M; Larsson AJM; Stenudd M; Eriksson C-J; Durif G; Stahl PL; Borgstrom E; Picelli S; Reinius B; Sandberg R; Reu P; Talavera-Lopez C; Andersson B; Blom K; Sandberg JK; Picard F; Michaelsson J; Frisen J

Article: NATURE GENETICS. 2021;53(5):694-706

Single-cell transcriptomics of human embryos identifies multiple sympathoblast lineages with potential implications for neuroblastoma origin

Kameneva P; Artemov AV; Kastriti ME; Faure L; Olsen TK; Otte J; Erickson A; Semsch B; Andersson ER; Ratz M; Frisen J; Tischler AS; de Krijger RR; Bouderlique T; Akkuratova N; Vorontsova M; Gusev O; Fried K; Sundstrom E; Mei S; Kogner P; Baryawno N; Kharchenko PV; Adameyko I

Article: ONCOGENE. 2021;40(16):2830-2841

The age of adult pilocytic astrocytoma cells

Voronina N; Aichmueller C; Kolb T; Korshunov A; Ryzhova M; Barnholtz-Sloan J; Cioffi G; Sill M; von Deimling A; Pfister SM; Gronych J; Jones DTW; Frisen J; Zapatka M; Ernst A

Article: NATURE COMMUNICATIONS. 2020;11(1):5860

Distinct oligodendrocyte populations have spatial preference and different responses to spinal cord injury

Floriddia EM; Lourenco T; Zhang S; van Bruggen D; Hilscher MM; Kukanja P; dos Santos JPG; Altinkok M; Yokota C; Llorens-Bobadilla E; Mulinyawe SB; Graos M; Sun LO; Frisen J; Nilsson M; Castelo-Branco G

Article: SCIENCE. 2020;370(6512):eabb8795

A latent lineage potential in resident neural stem cells enables spinal cord repair

Llorens-Bobadilla E; Chell JM; Le Merre P; Wu Y; Zamboni M; Bergenstrahle J; Stenudd M; Sopova E; Lundeberg J; Shupliakov O; Carlen M; Frisen J

Article: CELL STEM CELL. 2020;27(4):605-617.e5

A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury

Zamboni M; Llorens-Bobadilla E; Magnusson JP; Frisen J

Article: ELIFE. 2020;9:e59733

Activation of a neural stem cell transcriptional program in parenchymal astrocytes

Magnusson JP; Zamboni M; Santopolo G; Mold JE; Barrientos-Somarribas M; Talavera-Lopez C; Andersson B; Frisen J

Article: CELLS. 2020;9(7):E1732-1732

Blocking Notch-Signaling Increases Neurogenesis in the Striatum after Stroke

Santopolo G; Magnusson JP; Lindvall O; Kokaia Z; Frisen J

Journal article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(159)

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Zamboni M; Santopolo G; Frisén J

Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2020;(159)

Induction of Leptomeningeal Cells Modification Via Intracisternal Injection

Zamboni M; Santopolo G; Frisen J

Article: PLOS BIOLOGY. 2019;17(10):e3000383

Cell generation dynamics underlying naive T-cell homeostasis in adult humans

Mold JE; Reu P; Olin A; Bernard S; Michaelsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisen J

Article: NATURE METHODS. 2019;16(10):987-990

High-definition spatial transcriptomics for in situ tissue profiling

Vickovic S; Eraslan G; Salmen F; Klughammer J; Stenbeck L; Schapiro D; Aijo T; Bonneau R; Bergenstrahle L; Navarro JF; Gould J; Griffin GK; Borg A; Ronaghi M; Frisen J; Lundeberg J; Regev A; Stahl PL

Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019;39(7):1432-1447

Disruption of the Extracellular Matrix Progressively Impairs Central Nervous System Vascular Maturation Downstream of β-Catenin Signaling

Jensen LD; Hot B; Ramskold D; Germano RFV; Yokota C; Giatrellis S; Lauschke VM; Hubmacher D; Li MX; Hupe M; Arnold TD; Sandberg R; Frisen J; Trusohamn M; Martowicz A; Wisniewska-Kruk J; Nyqvist D; Adams RH; Apte SS; Vanhollebeke B; Stenman JM; Kele J

Article: GENOME BIOLOGY. 2019;20(1):68

Conbase: a software for unsupervised discovery of clonal somatic mutations in single cells through read phasing

Hard J; Al Hakim E; Kindblom M; Bjorklund AK; Sennblad B; Demirci I; Paterlini M; Reu P; Borgstrom E; Stahl PL; Michaelsson J; Mold JE; Frisen J

Article: NATURE BIOTECHNOLOGY. 2019;37(3):232-237

Regenerating the field of cardiovascular cell therapy

Chien KR; Frisen J; Fritsche-Danielson R; Melton DA; Murry CE; Weissman IL

Article: NATURE. 2019;566(7745):538-542

Dynamics of oligodendrocyte generation in multiple sclerosis

Yeung MSY; Djelloul M; Steiner E; Bernard S; Salehpour M; Possnert G; Brundin L; Frisen J

Article: NATURE PROTOCOLS. 2018;13(11):2501-2534

Barcoded solid-phase RNA capture for Spatial Transcriptomics profiling in mammalian tissue sections

Salmen F; Stahl PL; Mollbrink A; Navarro JF; Vickovic S; Frisen J; Lundeberg J

Article: LANCET NEUROLOGY. 2018;17(10):918-926

The hippocampus in multiple sclerosis

Rocca MA; Barkhof F; De Luca J; Frisen J; Geurts JJG; Hulst HE; Sastre-Garriga J; Filippi M

Article: CELL. 2018;173(1):153-165.e22

Reducing Pericyte-Derived Scarring Promotes Recovery after Spinal Cord Injury

Dias DO; Kim H; Holl D; Solnestam BW; Lundeberg J; Carlen M; Goritz C; Frisen J

Article: EBIOMEDICINE. 2018;27:176-181

Meningioma growth dynamics assessed by radiocarbon retrospective birth dating

Huttner HB; Bergmann O; Salehpour M; El Cheikh R; Nakamura M; Tortora A; Heinke P; Coras R; Englund E; Eyuepoglu IY; Kuramatsu JB; Roeder SS; Kloska SP; Muehlen I; Doerfler A; Schwab S; Possnert G; Bernard S; Frisen J

Article: CIRCULATION. 2017;136(7):680-686

Cardiomyocyte Regeneration A Consensus Statement

Eschenhagen T; Bolli R; Braun T; Field LJ; Fleischmann BK; Frisen J; Giacca M; Hare JM; Houser S; Lee RT; Marbn E; Martin JF; Molkentin JD; Murry CE; Riley PR; Ruiz-Lozano P; Sadek HA; Sussman MA; Hill JA

Article: CELL REPORTS. 2017;20(4):779-784

The Lifespan and Turnover of Microglia in the Human Brain

Reu P; Khosravi A; Bernard S; Mold JE; Salehpour M; Alkass K; Perl S; Tisdale J; Possnert G; Druid H; Frisen J

Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(2):309-317

Antibody-secreting plasma cells persist for decades in human intestine

Landsverk OJB; Snir O; Casado RB; Richter L; Mold JE; Reu P; Horneland R; Paulsen V; Yaqub S; Aandahl EM; Oyen OM; Thorarensen HS; Salehpour M; Possnert G; Frisen J; Sollid LM; Baekkevold ES; Jahnsen FL

Article: PLOS ONE. 2017;12(2):e0171566

Comparison of whole genome amplification techniques for human single cell exome sequencing

Borgstrom E; Paterlini M; Mold JE; Frisen J; Lundeberg J

Article: NATURE GENETICS. 2016;48(11):1430-1435

Analysis of allelic expression patterns in clonal somatic cells by single-cell RNA-seq

Reinius B; Mold JE; Ramskold D; Deng Q; Johnsson P; Michaelsson J; Frisen J; Sandberg R

Article: EXPERIMENTAL CELL RESEARCH. 2016;348(1):10-22

Eph receptor interclass cooperation is required for the regulation of cell proliferation

Jurek A; Genander M; Kundu P; Catchpole T; He X; Straat K; Sabelstrom H; Xu N-J; Pettersson S; Henkemeyer M; Frisen J

Article: NATURE COMMUNICATIONS. 2016;7:13182

Massive and parallel expression profiling using microarrayed single-cell sequencing

Vickovic S; Stahl PL; Salmen F; Giatrellis S; Westholm JO; Mollbrink A; Navarro JF; Custodio J; Bienko M; Sutton L-A; Rosenquist R; Frisen J; Lundeberg J

Article: SCIENCE. 2016;353(6294):78-82

Visualization and analysis of gene expression in tissue sections by spatial transcriptomics

Stahl PL; Salmen F; Vickovic S; Lundmark A; Navarro JF; Magnusson J; Giacomello S; Asp M; Westholm JO; Huss M; Mollbrink A; Linnarsson S; Codeluppi S; Borg A; Ponten F; Costea PI; Sahlen P; Mulder J; Bergmann O; Lundeberg J; Frisen J

Article: CELL METABOLISM. 2015;22(3):408-417

Transplanted Bone Marrow-Derived Cells Contribute to Human Adipogenesis

Ryden M; Uzunel M; Hard JL; Borgstrom E; Mold JE; Arner E; Mejhert N; Andersson DP; Widlund Y; Hassan M; Jones CV; Spalding KL; Svahn B-M; Ahmadian A; Frisen J; Bernard S; Mattsson J; Arner P

Article: STEM CELL REPORTS. 2015;5(2):174-184

Alpha-Synuclein Expression in the Oligodendrocyte Lineage: an In Vitro and In Vivo Study Using Rodent and Human Models

Djelloul M; Holmqvist S; Boza-Serrano A; Azevedo C; Yeung MS; Goldwurm S; Frisen J; Deierborg T; Roybon L

Article: COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY. 2015;7(7):a018994

Adult Neurogenesis in Humans

Bergmann O; Spalding KL; Frisen J

Article: CELL. 2015;161(7):1566-1575

Dynamics of Cell Generation and Turnover in the Human Heart

Bergmann O; Zdunek S; Felker A; Salehpour M; Alkass K; Bernard S; Sjostrom SL; Szewczykowska M; Jackowska T; dos Remedios C; Malm T; Andrae M; Jashari R; Nyengaard JR; Possnert G; Jovinge S; Druid H; Frisen J

Article: SCIENCE TRANSLATIONAL MEDICINE. 2015;7(281):281ra44

An EphB-Abl signaling pathway is associated with intestinal tumor initiation and growth

Kundu P; Genander M; Straat K; Classon J; Ridgway RA; Tan EH; Bjork J; Martling A; van Es J; Sansom OJ; Clevers H; Pettersson S; Frisen J

Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(3):1339-1346

Safety and tolerability of intracerebroventricular PDGF-BB in Parkinson's disease patients

Paul G; Zachrisson O; Varrone A; Almqvist P; Jerling M; Lind G; Rehncrona S; Linderoth B; Bjartmarz H; Shafer LL; Coffey R; Svensson M; Mercer KJ; Forsberg A; Halldin C; Svenningsson P; Widner H; Frisen J; Palhagen S; Haegerstrand A

Article: JAMA NEUROLOGY. 2015;72(2):235-237

Role of Endogenous Neural Stem Cells in Spinal Cord Injury and Repair

Stenudd M; Sabelstroem H; Frisen J

Article: PLOS BIOLOGY. 2015;13(1):e1002045

Adult Neurogenesis in Humans-Common and Unique Traits in Mammals

Ernst A; Frisen J

Article: CELL. 2014;159(4):766-774

Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain

Yeung MSY; Zdunek S; Bergmann O; Bernard S; Salehpour M; Alkass K; Perl S; Tisdale J; Possnert G; Brundin L; Druid H; Frisen J

Article: SCIENCE. 2014;346(6206):237-241

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

Magnusson JP; Goritz C; Tatarishvili J; Dias DO; Smith EMK; Lindvall O; Kokaia Z; Frisen J

Article: NEURON. 2014;83(5):1085-1097

A Transcriptional Mechanism Integrating Inputs from Extracellular Signals to Activate Hippocampal Stem Cells

Andersen J; Urban N; Achimastou A; Ito A; Simic M; Ullom K; Martynoga B; Lebel M; Goritz C; Frisen J; Nakafuku M; Guillemot F

Article: NATURE NEUROSCIENCE. 2014;17(6):801-803

The age and genomic integrity of neurons after cortical stroke in humans

Huttner HB; Bergmann O; Salehpour M; Racz A; Tatarishvili J; Lindgren E; Csonka T; Csiba L; Hortobagyi T; Mehes G; Englund E; Solnestam BW; Zdunek S; Scharenberg C; Strom L; Stahl P; Sigurgeirsson B; Dahl A; Schwab S; Possnert G; Bernard S; Kokaia Z; Lindvall O; Lundeberg J; Frisen J

Article: CELL. 2014;156(5):1072-1083

Neurogenesis in the Striatum of the Adult Human Brain

Ernst A; Alkass K; Bernard S; Salehpour M; Perl S; Tisdale J; Possnert G; Druid H; Frisen J

Article: SCIENCE. 2013;342(6158):637-640

Resident Neural Stem Cells Restrict Tissue Damage and Neuronal Loss After Spinal Cord Injury in Mice

Sabelstrom H; Stenudd M; Reu P; Dias DO; Elfineh M; Zdunek S; Damberg P; Goritz C; Frisen J

Article: CELL. 2013;153(6):1219-1227

Dynamics of Hippocampal Neurogenesis in Adult Humans

Spalding KL; Bergmann O; Alkass K; Bernard S; Salehpour M; Huttner HB; Bostrom E; Westerlund I; Vial C; Buchholz BA; Possnert G; Mash DC; Druid H; Frisen J

Article: LAKARTIDNINGEN. 2012;109(41):1814

[2012 Nobel Prize in Physiology or Medicine. Nobel Prize for a life return ticket].

Frisén J

Article: NEURON. 2012;74(4):634-639

The Age of Olfactory Bulb Neurons in Humans

Bergmann O; Liebl J; Bernard S; Alkass K; Yeung MSY; Steier P; Kutschera W; Johnson L; Landen M; Druid H; Spalding KL; Frisen J

Article: SCIENCE. 2011;333(6039):238-242

A Pericyte Origin of Spinal Cord Scar Tissue

Goritz C; Dias DO; Tomilin N; Barbacid M; Shupliakov O; Frisen J

Article: CELL STEM CELL. 2011;8(4):426-433

Dopamine Controls Neurogenesis in the Adult Salamander Midbrain in Homeostasis and during Regeneration of Dopamine Neurons

Berg DA; Kirkham M; Wang H; Frisen J; Simon A

Article: EXPERIMENTAL CELL RESEARCH. 2011;317(2):188-194

Identification of cardiomyocyte nuclei and assessment of ploidy for the analysis of cell turnover

Bergmann O; Zdunek S; Alkass K; Druid H; Bernard S; Frisen J

Article: CELL STEM CELL. 2010;7(6):730-743

EphB Signaling Controls Lineage Plasticity of Adult Neural Stem Cell Niche Cells

Nomura T; Goritz C; Catchpole T; Henkemeyer M; Frisen J

Article: JOURNAL OF NEUROSCIENCE. 2010;30(41):13794-13807

RBPJκ-Dependent Signaling Is Essential for Long-Term Maintenance of Neural Stem Cells in the Adult Hippocampus

Ehm O; Goritz C; Covic M; Schaeffner I; Schwarz TJ; Karaca E; Kempkes B; Kremmer E; Pfrieger FW; Espinosa L; Bigas A; Giachino C; Taylor V; Frisen J; Lie DC

Article: CELL STEM CELL. 2010;7(4):470-482

Origin of New Glial Cells in Intact and Injured Adult Spinal Cord

Barnabe-Heider F; Goritz C; Sabelstrom H; Takebayashi H; Pfrieger FW; Meletis K; Frisen J

Article: CURRENT OPINION IN CELL BIOLOGY. 2010;22(5):611-616

Ephrins and Eph receptors in stem cells and cancer

Genander M; Frisen J

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(33):14657-14661

Efficient reprogramming of adult neural stem cells to monocytes by ectopic expression of a single gene

Forsberg M; Carlen M; Meletis K; Yeung MSY; Barnabe-Heider F; Persson MAA; Aarum J; Frisen J

Article: STEM CELLS. 2010;28(7):1196-1205

Ephrins Negatively Regulate Cell Proliferation in the Epidermis and Hair Follicle

Genander M; Holmberg J; Frisen J

Article: STEM CELLS. 2010;28(5):974-983

Impaired Hippocampal Neurogenesis and Vascular Formation in Ephrin-A5-Deficient Mice

Hara Y; Nomura T; Yoshizaki K; Frisen J; Osumi N

Article: BRAIN. 2010;133(Pt 4):983-995

A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2α

Seidel S; Garvalov BK; Wirta V; von Stechow L; Schaenzer A; Meletis K; Wolter M; Sommerlad D; Henze A-T; Nister M; Reifenberger G; Lundeberg J; Frisen J; Acker T

Article: DIABETES. 2010;59(1):105-109

Adipocyte Turnover: Relevance to Human Adipose Tissue Morphology

Arner E; Westermark PO; Spalding KL; Britton T; Ryden M; Frisen J; Bernard S; Arner P

Article: CELL. 2009;139(4):679-692

Dissociation of EphB2 Signaling Pathways Mediating Progenitor Cell Proliferation and Tumor Suppression

Genander M; Halford MM; Xu N-J; Eriksson M; Yu Z; Qiu Z; Martling A; Greicius G; Thakar S; Catchpole T; Chumley MJ; Zdunek S; Wang C; Holm T; Goff SP; Pettersson S; Pestell RG; Henkemeyer M; Frisen J

Article: PLOS ONE. 2009;4(9):e6997

High-density microwell chip for culture and analysis of stem cells.

Lindström S; Eriksson M; Vazin T; Sandberg J; Lundeberg J; Frisén J; Andersson-Svahn H

Article: SCIENCE. 2009;324(5923):98-102

Evidence for Cardiomyocyte Renewal in Humans

Bergmann O; Bhardwaj RD; Bernard S; Zdunek S; Barnabe-Heider F; Walsh S; Zupicich J; Alkass K; Buchholz BA; Druid H; Jovinge S; Frisen J

Article: NATURE NEUROSCIENCE. 2009;12(3):259-267

Forebrain ependymal cells are Notch-dependent and generate neuroblasts and astrocytes after stroke

Carlen M; Meletis K; Goritz C; Darsalia V; Evergren E; Tanigaki K; Amendola M; Barnabe-Heider F; Yeung MSY; Naldini L; Honjo T; Kokaia Z; Shupliakov O; Cassidy RM; Lindvall O; Frisen J

Article: EXPERIMENTAL CELL RESEARCH. 2008;314(17):3255-3263

Induced pluripotency with endogenous and inducible genes

Duinsbegen D; Eriksson M; 't Hoen PAC; Frisen J; Mikkers H

Article: PLOS ONE. 2008;3(10):e3322

Meltrin beta/ADAM19 interacting with EphA4 in developing neural cells participates in formation of the neuromuscular junction.

Yumoto N; Wakatsuki S; Kurisaki T; Hara Y; Osumi N; Frisén J; Sehara-Fujisawa A

Article: DEVELOPMENT. 2008;135(19):3281-3290

Temporal regulation of ephrin/Eph signalling is required for the spatial patterning of the mammalian striatum

Passante L; Gaspard N; Degraeve M; Frisen J; Kullander K; De Maertelaer V; Vanderhaeghen P

Article: PLOS BIOLOGY. 2008;6(7):e182-1507

Spinal cord injury reveals multilineage differentiation of ependymal cells

Meletis K; Barnabe-Heider F; Carlen M; Evergren E; Tomilin N; Shupliakov O; Frisen J

Article: CELL STEM CELL. 2008;3(1):16-24

Stem cells for spinal cord repair

Barnabe-Heider F; Frisen J

Article: NATURE. 2008;453(7196):783-787

Dynamics of fat cell turnover in humans

Spalding KL; Arner E; Westermark PO; Bernard S; Buchholz BA; Bergmann O; Blomqvist L; Hoffstedt J; Naslund E; Britton T; Concha H; Hassan M; Ryden M; Frisen J; Arner P

Article: NATURE METHODS. 2008;5(2):189-196

Genetic manipulation of adult mouse neurogenic niches by in vivo electroporation

Barnabe-Heider F; Meletis K; Eriksson M; Bergmann O; Sabelstrom H; Harvey MA; Mikkers H; Frisen J

Article: GLIA. 2007;55(15):1565-1576

Transgenic mice for conditional gene manipulation in astroglial cells

Slezak M; Goritz C; Niemiec A; Frisen J; Chambon P; Metzger D; Pfrieger FW

Article: STEM CELLS. 2007;25(6):1539-1545

High-throughput identification of genes promoting neuron formation and lineage choice in mouse embryonic stem cells

Falk A; Karlsson TE; Kurdija S; Frisen J; Zupicich J

Article: SCIENCE. 2007;315(5816):1243-1249

Human neuroblasts migrate to the olfactory bulb via a lateral ventricular extension

Curtis MA; Kam M; Nannmark U; Anderson MF; Axell MZ; Wikkelso C; Holtas S; van Roon-Mom WMC; Bjork-Eriksson T; Nordborg C; Frisen J; Dragunow M; Faull RLM; Eriksson PS

Article: EXPERIMENTAL CELL RESEARCH. 2006;312(15):2851-2859

Genetic visualization of neurogenesis

Carlen M; Meletis K; Barnabe-Heider F; Frisen J

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(33):12564-12568

Neocortical neurogenesis in humans is restricted to development

Bhardwaj RD; Curtis MA; Spalding KL; Buchholz BA; Fink D; Bjork-Eriksson T; Nordborg C; Gage FH; Druid H; Eriksson PS; Frisen J

Article: NEUROSCIENCE. 2006;141(1):109-121

Ephrin-A5 modulates the topographic mapping and connectivity of commissural axons in murine hippocampus

Otal R; Burgaya F; Frisen J; Soriano E; Martinez A

Article: CELL. 2006;125(6):1151-1163

EphB receptors coordinate migrationand proliferation in the intestinal stem cell niche

Holmberg J; Genander M; Halford MM; Anneren C; Sondell M; Chumley MJ; Silvany RE; Henkemeyer M; Frisen J

Article: EXPERIMENTAL CELL RESEARCH. 2006;312(10):1798-1812

Catalog of gene expression in adult neural stem cells and their in vivo microenvironment

Williams C; Wirta V; Meletis K; Wikstrom L; Carlsson L; Frisen J; Lundeberg J

Article: NANOTECHNOLOGY. 2006;17(8):1911-1915

Magnetic resonance tracking of nanoparticle labelled neural stem cells in a rat's spinal cord

Wang FH; Lee IH; Holmstrom N; Yoshitake T; Kim DK; Muhammed M; Frisen J; Olson L; Spenger C; Kehr J

Article: DEVELOPMENT. 2006;133(7):1335-1345

Pax6-dependent boundary defines alignment of migrating olfactory cortex neurons via the repulsive activity of ephrin A5

Nomura T; Holmberg J; Frisen J; Osumi N

Article: DEVELOPMENT. 2006;133(2):363-369

P53 suppresses the self-renewal of adult neural stem cells

Meletis K; Wirta V; Hede SM; Nistér M; Lundeberg J; Frisén J

Article: BMC NEUROSCIENCE. 2005;6:55

Epidermal growth factor (EGF) withdrawal masks gene expression differences in the study of pituitary adenylate cyclase-activating polypeptide (PACAP) activation of primary neural stem cell proliferation -: art. no. 55

Sievertzon M; Wirta V; Mercer A; Frisén J; Lundeberg J

Article: EMBO JOURNAL. 2005;24(15):2715-2719

Deconstructing stemness

Mikkers H; Frisén J

Article: CELL. 2005;122(1):133-143

Retrospective birth dating of cells in humans

Spalding KL; Bhardwaj RD; Buchholz BA; Druid H; Frisén J

Article: BMC NEUROSCIENCE. 2005;6:28

Transcriptome analysis in primary neural stem cells using a tag cDNA amplification method -: art. no. 28

Sievertzon M; Wirta V; Mercer A; Meletis K; Erlandsson R; Wikström L; Frisén J; Lundeberg J

Article: NATURE NEUROSCIENCE. 2005;8(3):346-353

Allodynia limits the usefulness of intraspinal neural stem cell grafts; directed differentiation improves outcome

Hofstetter CP; Holmström NAV; Lilja JA; Schweinhardt P; Hao JX; Spenger C; Wiesenfeld-Hallin Z; Kurpad SN; Frisén J; Olson L

Article: GENES & DEVELOPMENT. 2005;19(4):462-471

Ephrin-A2 reverse signaling negatively regulates neural progenitor proliferation and neurogenesis

Holmberg J; Armulik A; Senti KA; Edoff K; Spalding K; Momma S; Cassidy R; Flanagan JG; Frisén J

Article: EXPERIMENTAL CELL RESEARCH. 2005;302(1):40-47

Survival and neural differentiation of adult neural stem cells transplanted into the mature inner ear

Hu ZQ; Wei DG; Johansson CB; Holmström N; Duan ML; Frisén J; Ulfendahl M

Article: CELL. 2003;114(3):311-322

Axonal ephrin-as and odorant receptors:: Coordinate determination of the olfactory sensory map

Cutforth T; Moring L; Mendelsohn M; Nemes A; Shah NM; Kim MM; Frisén J; Axel R

Article: NEURON. 2003;39(3):453-465

Area specificity and topography of thalamocortical projections are controlled by ephrin/Eph genes

Dufour A; Seibt J; Passante L; Depaepe V; Ciossek T; Frisén J; Kullander K; Flanagan JG; Polleux F; Vanderhaeghen P

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(13):7925-7930

Evidence for neurogenesis in the adult mammalian substantia nigra

Zhao M; Momma S; Delfani K; Carlén M; Cassidy RM; Johansson CB; Brismar H; Shupliakov O; Frisén J; Janson AM

Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2002;69(6):757-762

Amphiregulin is a mitogen for adult neural stem cells

Falk A; Frisén J

Article: EXPERIMENTAL CELL RESEARCH. 2002;279(1):34-39

Gene delivery to adult neural stem cells

Falk A; Holmström N; Carlén M; Cassidy R; Lundberg C; Frisén J

Article: CURRENT BIOLOGY. 2002;12(7):606-608

Functional integration of adult-born neurons

Carlén M; Cassidy RM; Brismar H; Smith GA; Enquist LW; Frisén J

Article: BIOESSAYS. 2001;23(1):3-7

Oh no, Notch again!

Frisén J; Lendahl U

Article: NATURE. 2000;408(6809):203-206

Regulation of repulsion versus adhesion by different splice forms of an Eph receptor

Holmberg J; Clarke DL; Frisén J

Article: JOURNAL OF NEUROSCIENCE. 2000;20(15):5841-5847

Malformation of the functional organization of somatosensory cortex in adult ephrin-A5 knock-out mice revealed by in vivo functional imaging

Prakash N; Vanderhaeghen P; Cohen-Cory S; Frisén J; Flanagan JG; Frostig RD

Article: SCIENCE. 2000;288(5471):1660-1663

Generalized potential of adult neural stem cells

Clarke DL; Johansson CB; Wilbertz J; Veress B; Nilsson E; Karlström H; Lendahl U; Frisén J

Article: NATURE NEUROSCIENCE. 2000;3(4):358-365

A mapping label required for normal scale of body representation in the cortex

Vanderhaeghen P; Lu Q; Prakash N; Frisén J; Walsh CA; Frostig RD; Flanagan JG

Article: NEURON. 2000;25(3):563-574

Genetic analysis of ephrin-A2 and ephrin-A5 shows their requirement in multiple aspects of retinocollicular mapping.

Feldheim DA; Kim YI; Bergemann AD; Frisén J; Barbacid M; Flanagan JG

Article: EXPERIMENTAL CELL RESEARCH. 2000;255(1):47-55

Expression of the adenovirus receptor and its interaction with the fiber knob

Tomko RP; Johansson CB; Totrov M; Abagyan R; Frisén J; Philipson L

Article: NEURON. 2000;25(2):295-306

Roles for ephrins in positionally selective synaptogenesis between motor neurons and muscle fibers

Feng GP; Laskowski MB; Feldheim DA; Wang HM; Lewis R; Frisen J; Flanagan JG; Sanes JR

Article: EXPERIMENTAL CELL RESEARCH. 1999;253(2):733-736

Neural stem cells in the adult human brain

Johansson CB; Svensson M; Wallstedt L; Janson AM; Frisén J

Article: JOURNAL OF CELL BIOLOGY. 1999;145(3):503-514

Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin

Pekny M; Johansson CB; Eliasson C; Stakeberg J; Wallén Å; Perlmann T; Lendahl U; Betsholtz C; Berthold CH; Frisén J

Article: CELL. 1999;96(1):25-34

Identification of a neural stem cell in the adult mammalian central nervous system

Johansson CB; Momma S; Clarke DL; Risling M; Lendahl U; Frisén J

Article: NEURON. 1998;21(6):1303-1313

Topographic guidance labels in a sensory projection to the forebrain

Feldheim DA; Vanderhaeghen P; Hansen MJ; Frisén J; Lu Q; Barbacid M; Flanagan JG

Article: NATURE. 1998;395(6700):398-402

Retinoid-X receptor signalling in the developing spinal cord

Solomin L; Johansson CB; Zetterström RH; Bissonnette RP; Heyman RA; Olson L; Lendahl U; Frisén J; Perlmann T

Article: JOURNAL OF NEUROSCIENCE. 1998;18(15):5714-5722

Nerve growth factor induces process formation in meningeal cells:: Implications for scar formation in the injured CNS

Frisén J; Risling M; Korhonen L; Zirrgiebel U; Johansson CB; Cullheim S; Lindholm D

Article: NEURON. 1998;20(2):235-243

Ephrin-A5 (AL-1/RAGS) is essential for proper retinal axon guidance and topographic mapping in the mammalian visual system.

Frisén J; Yates PA; McLaughlin T; Friedman GC; O'Leary DD; Barbacid M

Article: CELL AND TISSUE RESEARCH. 1997;290(2):209-215

Genetic analysis of the role of Eph receptors in the development of the mammalian nervous system.

Frisén J; Barbacid M

Article: EMBO JOURNAL. 1997;16(11):3106-3114

Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors.

Park S; Frisén J; Barbacid M

Article: JOURNAL OF NEUROSCIENCE. 1997;17(10):3623-3633

TrkB signaling is required for postnatal survival of CNS neurons and protects hippocampal and motor neurons from axotomy-induced cell death.

Alcántara S; Frisén J; del Río JA; Soriano E; Barbacid M; Silos-Santiago I

Article: GENES & DEVELOPMENT. 1997;11(8):973-983

Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development.

Yan Y; Frisén J; Lee MH; Massagué J; Barbacid M

Article: EXPERIMENTAL NEUROLOGY. 1997;143(1):132-140

Apoptotic death of olfactory sensory neurons in the adult rat

Deckner ML; Risling M; Frisen J

Article: NATURE. 1996;382(6586):70-73

Renal agenesis and the absence of enteric neurons in mice lacking GDNF.

Sánchez MP; Silos-Santiago I; Frisén J; He B; Lira SA; Barbacid M

Article: JOURNAL OF CELL BIOLOGY. 1995;131(2):453-464

RAPID, WIDESPREAD, AND LONG-LASTING INDUCTION OF NESTIN CONTRIBUTES TO THE GENERATION OF GLIAL SCAR TISSUE AFTER CNS INJURY

FRISEN J; JOHANSSON CB; TOROK C; RISLING M; LENDAHL U

Article: NEUROSCIENCE. 1995;65(1):293-304

SPINAL AXONS IN CENTRAL-NERVOUS-SYSTEM SCAR TISSUE ARE CLOSELY-RELATED TO LAMININ-IMMUNOREACTIVE ASTROCYTES

FRISEN J; HAEGERSTRAND A; RISLING M; FRIED K; JOHANSSON CB; HAMMARBERG H; ELDE R; HOKFELT T; CULLHEIM S

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