Johan Kolmert
Biträdande Lektor
E-postadress: johan.kolmert@ki.se
Besöksadress: Nobels väg 13, 17177 Stockholm
Postadress: C6 Institutet för miljömedicin, C6 Integrativ metabolomik Wheelock, 171 77 Stockholm
Om mig
- My research focus is to identify inflammatory disease mechanisms involving
the biosynthesis of lipid mediators in eosinophils, mast cells and epithelial
cells, to describe sub-phenotypes of asthma.
As assistant professor my research experience originates from studies on
polyunsaturated fatty acids (omega-3/6 PUFAs) metabolism, such as
eicosanoids, and their role in multiple inflammatory diseases. My 19-year
background in chromatography and mass spectrometry-based techniques, together
with more than a decade of working in pharmaceutical industry with drug
development, has lend me a broad scientific expertise with an international
network of co-workers. I believe that my passion for joint collaborative
team-work with clinicians, business developers and experimental scientists
has been the success to my scientific achievments.
Forskningsbeskrivning
- I use my bioanalytical experience to study inflammatory driving processes in
asthma, (lipid mediators such as prostaglandin, leukotriene and related fatty
acids), and key inflammatory plasma proteins in both asthma, rheumatoid
arthritis and systemic sclerosis. Central to my findings is the involvement
of key effector cells, such as mast cells and eosinophils, as drivers of
inflammatory events. From my metabolomics background my research has focused
on targeted LC-MS/MS analysis of urine eicosanoid excretion patterns and how
we can use eicosanoid profiles in urine from asthmatics to subgroup patients
in a new way - solely based on the molecular pattern in urine. This research
is currently ongoing, with the ultimate goal to contextualize these molecular
subgroups in light of known and unknown clinical subtypes of asthmatics and
to build predictive models that can aid clinical decisions regarding
personalized treatment. Furthermore, I am excited about evaluating newly
collected results from both in-vivo, ex-vivo and in vitro studies to progress
new drug compounds in collaboration with pharmaceutical companies, across the
range from early drug discovery through-out clinical development. I am active
member in the IMI funded U-BIOPRED Alliance project and contribute also to
the following academic research initiatives - RASP U.K, COPSAC, VDAART,
BioCross and Breath.
Undervisning
- Acting as supervisor for post docs and research technicians
Currently co-supervising one PhD student.
Artiklar
- Article: EUROPEAN RESPIRATORY JOURNAL. 2024;64(5):2400207
- Article: JAMA DERMATOLOGY. 2024;160(10):1082-1090
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2024;154(3):670-678
- Article: ANNALS OF THE AMERICAN THORACIC SOCIETY. 2024
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2024;210(3):288-297
- Article: HELIYON. 2024;10(14):e34386
- Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2024;170:106789
- Article: ERJ OPEN RESEARCH. 2023;9(5):00269-02023
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2023;208(2):142-154
- Article: FREE RADICAL BIOLOGY AND MEDICINE. 2023;194:308-315
- Article: MOLECULAR NUTRITION AND FOOD RESEARCH. 2022;66(24):e2200351
- Article: CLINICAL AND TRANSLATIONAL MEDICINE. 2022;12(9):e895
- Article: EUROPEAN RESPIRATORY JOURNAL. 2022;59(6):2101733
- Article: MUCOSAL IMMUNOLOGY. 2022;15(3):515-524
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2022;205(4):397-411
- Article: EUROPEAN RESPIRATORY JOURNAL. 2022;59(2):2100142
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):89-101
- Article: EUROPEAN JOURNAL OF PHARMACOLOGY. 2021;907:174282
- Article: BIOCHIMICA ET BIOPHYSICA ACTA - MOLECULAR AND CELL BIOLOGY OF LIPIDS. 2021;1866(5):158886
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2021;51(4):594-603
- Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(1):37-53
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(5):1198-1213
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(1):70-82
- Article: JOURNAL OF LIPID RESEARCH. 2019;60(6):1164-1173
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;142(4):1080-1089
- Article: ANALYTICAL CHEMISTRY. 2018;90(17):10239-10248
- Article: PROSTAGLANDINS AND OTHER LIPID MEDIATORS. 2018;137:20-29
- Article: PLOS ONE. 2018;13(9):e0203874
- Article: JOURNAL OF LIPID RESEARCH. 2017;58(12):2275-2288
- Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2017;47(7):909-917
- Article: EUROPEAN RESPIRATORY JOURNAL. 2017;49(6):1602322
- Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(6):1797-1807
- Article: RESPIRATORY RESEARCH. 2016;17(1):165
- Article: ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2014;406(6):1751-1762
- Journal article: TOXICOLOGY LETTERS. 2012;211:s47
- Article: BIOMARKERS. 2009;14(8):572-586
- Journal article: BIOMARKERS. 2009;00(00):090925060950032-090925060950016
- Article: JOURNAL OF CHROMATOGRAPHY A. 2008;1192(1):139-146
- Article: ANALYTICAL CHEMISTRY. 2006;78(4):975-983
- Visa fler
Alla övriga publikationer
- Letter: EUROPEAN RESPIRATORY JOURNAL. 2022;60(6):2201795
- Corrigendum: MUCOSAL IMMUNOLOGY. 2022;15(4):798
- Letter: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76(7):2270-2273
- Letter: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(9):1204-1205
- Letter: EUROPEAN RESPIRATORY JOURNAL. 2019;53(6):1900453
- Thesis / dissertation: 2018
Anställningar
- Biträdande Lektor, Institutet för miljömedicin, Karolinska Institutet, 2023-2029
Examina och utbildning
- Medicine Doktorsexamen, Institutet för miljömedicin, Karolinska Institutet, 2018