Johan Björkegren
Senior Forskare
| Docent
E-postadress: johan.bjorkegren@ki.se
Telefon: +46852482911
Besöksadress: Novum, Blickagången 6, 14157 Huddinge/Stockholm
Postadress: H7 Medicin, Huddinge, H7 Metabolism/ICMC Björkegren, 171 77 Stockholm
Om mig
- Med fokus på hjärt-kärlsjukdom är det övergripande målet med
forskningen att generera och analysera multimodala och högdimensionella
(”big”) databaser, för att från dessa beräkna fram robusta nätverk.
2013-
* PROFESSOR | Genetics and Genomic Sciences
* PROFESSOR | Medicine, Cardiology
Department of Genetics and Genomic Sciences, Icahn Institute for Genomics
and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York,
NY
2003- Associate Professor of Molecular Medicine, Karolinska Institutet,
Stockholm, Sweden
2015- Visiting Professor, University of Tartu, Tartu, Estonia
Forskningsbeskrivning
- Med fokus på hjärt-kärlsjukdom är det övergripande målet med vår
forskning att generera och analysera multimodala och högdimensionell
(”big”) databaser, för att från dessa beräkna fram robusta
nätverksmodeller av humanbiologi och sjukdom. Nätverksmodeller har en stark
potential att förbättra vår förmåga att tidigt diagnosticera sjukdom,
identifiera nya behandlingar samt att följa hur olika behandlingsstrategier
påverkar sjukdomsförloppet.
För att utveckla nätverksmodeller har min forskargrupp initierat en rad
studier med tonvikten på bred klinisk karaktäristik som tillsammans med
detaljerad bilddiagnostisk och flera lager av -omik data (vävnads- och
cellnivå data i form av DNA, RNA, och proteiner). Vi är övertygade om
att komplexa sjukdomar som hjärt-kärlsjukdom inte enbart kan förstås
genom studier av enskilda gener i isolerade sjukdomsvägar (”pathways”).
Parallellt måste den övergripande förståelsen för hur etablerade och nya
sjukdomsvägar hänger ihop och påverkar varandra, både inom och mellan
sjukdomsrelevanta vävnader och organ förbättras. Utan välfungerande
nätverksmodeller riskerar vi utvecklingen av precisionsmedicin.
*STARNET studien*
STARNET studien (Stockholm-Tartu Atherosclerosis Reverse Network Engineering
Task) är central för vår verksamhet och mål: Sedan 2007 har vi i
samarbete med Dr. Arno Ruusalepp, chef för Thoraxkirurgen på Tartu
Universitetssjukhus i Estland, samlat sjukdomsrelevanta vävnadsprover från
över 1500 patienter både med och utan hjärt-kärlsjukdom. STARNET omfattar
idag omikdata på tusentals vävnader från hundratals av dessa patienter,
vilket resulterat i publikationer i ledande tidskrifter.
Mer detaljer om vår forskning finns på min engelska KI profilsida [1]* *
*Publikationer*
Komplett lista över mina publicerade arbeten [2]
[1] https://staff.ki.se/people/johan-bjorkegren
[2] https://www.ncbi.nlm.nih.gov/myncbi/johan.bjorkegren.1/bibliography/public/
Artiklar
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Journal article: LIFE SCIENCE ALLIANCE. 2024;7(7):e202402603
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Article: CIRCULATION RESEARCH. 2024;134(11):1405-1423
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Article: STAR PROTOCOLS. 2024;5(1):102883
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Article: CELL GENOMICS. 2024;4(1):100465
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Article: ELIFE. 2023;12:rp88266
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Journal article: ELIFE. 2023;12
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Article: CELL REPORTS. 2023;42(11):113371
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Article: CELL REPORTS. 2023;42(11):113380
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2023;43(10):1836-1850
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Article: NATURE GENETICS. 2023;55(10):1651-1664
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Article: ISCIENCE. 2023;26(9):107513
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Article: CELL GENOMICS. 2023;3(8):100347
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Article: INTERNATIONAL JOURNAL OF CARDIOLOGY. 2023;383:15-23
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Article: CIRCULATION RESEARCH. 2023;132(9):1144-1161
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Journal article: MEDRXIV. 2023;:2023.02.09.23285622
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Article: CIRCULATION RESEARCH. 2023;132(3):323-338
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Article: ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY. 2023;249:114426
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Article: FRONTIERS IN ENDOCRINOLOGY. 2023;14:1186252
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Article: NATURE GENETICS. 2022;54(12):1803-1815
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Article: NAT CARDIOVASC RES. 2022;1(12):1174-1186
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Article: NAT CARDIOVASC RES. 2022;1(12):1140-1155
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Article: JOURNAL OF AGING STUDIES. 2022;63:101074
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Article: DEVELOPMENTAL CELL. 2022;57(20):2426-2443.e6
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Article: CARDIOVASCULAR RESEARCH. 2022;118(13):2792-2804
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Article: METABOLITES. 2022;12(9):840
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Article: PLOS GENETICS. 2022;18(6):e1010261
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Article: NATURE GENETICS. 2022;54(6):804-816
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Article: STEM CELL REPORTS. 2022;17(5):1089-1104
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Journal article: FASEB JOURNAL. 2022;36(S1)
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Article: CARDIOVASCULAR RESEARCH. 2022;118(4):1088-1102
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Article: BASIC RESEARCH IN CARDIOLOGY. 2022;117(1):6
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Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2022;15(1):e003365
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Article: NAT CARDIOVASC RES. 2022;1(1):85-100
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Article: NATURE METABOLISM. 2021;3(11):1552-1568
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Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2021;41
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(15):131178
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Article: JOURNAL OF HUMAN GENETICS. 2021;66(6):625-636
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Article: CIRCULATION. 2021;143(18):1809-1823
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Article: NATURE COMMUNICATIONS. 2021;12(1):1610
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Article: EUROPEAN HEART JOURNAL. 2021;42(9):919-933
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Article: CIRCULATION. 2021;143(7):713-726
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Article: NATURE COMMUNICATIONS. 2021;12(1):547
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Article: CIRCULATION RESEARCH. 2020;127(12):1552-1565
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Article: CIRCULATION. 2020;142(21):2045-2059
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Article: BASIC RESEARCH IN CARDIOLOGY. 2020;115(6):67
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Article: ATHEROSCLEROSIS. 2020;311:20-29
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Article: NATURE COMMUNICATIONS. 2020;11(1):3953
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(27):15818-15826
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Article: BIOINFORMATICS. 2020;36(12):3910-3912
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Journal article: JOURNAL OF THE ENDOCRINE SOCIETY. 2020;4(Supplement_1):or09-or04
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Article: BIOINFORMATICS. 2020;36(6):1807-1813
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Article: CARDIOVASCULAR RESEARCH. 2020;116(1):63-77
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2019;39(11):2386-2401
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Article: NATURE MEDICINE. 2019;25(10):1576-1588
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Article: NATURE COMMUNICATIONS. 2019;10(1):3834
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Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2019;73(23):2946-2957
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Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2019;12(6):e002390
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Article: NUCLEIC ACIDS RESEARCH. 2019;47(7):e39
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Article: NATURE GENETICS. 2019;51(4):592-599
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Article: DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION. 2019;2019:baz046
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Article: NATURE COMMUNICATIONS. 2018;9(1):5141
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Article: PLOS GENETICS. 2018;14(12):e1007799
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Article: PLOS GENETICS. 2018;14(11):e1007755
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Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2018;11(9):e002030
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Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2018;11(9):e002115
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2018;38(8):1711-1722
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Journal article: EUROPEAN HEART JOURNAL. 2018;39(suppl_1):ehy565.p1844
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Journal article: EUROPEAN HEART JOURNAL. 2018;39(suppl_1):ehy566.p6551
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Article: STEM CELL REPORTS. 2018;11(1):242-257
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Article: JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY. 2018;119:147-154
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Article: CELL METABOLISM. 2018;27(5):1138-1155.e6
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Article: NATURE GENETICS. 2018;50(4):524-537
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Article: SCIENTIFIC REPORTS. 2018;8(1):3434
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Article: PEERJ. 2018;6:e4466
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Article: ATHEROSCLEROSIS. 2017;267:39-48
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Article: SCIENTIFIC REPORTS. 2017;7(1):10633
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Article: NATURE GENETICS. 2017;49(9):1385-1391
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Article: CIRCULATION. 2017;136(5):476-489
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Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2017;100(6):885-894
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Article: AMERICAN HEART JOURNAL. 2017;187:170-181
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Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2017;10(2):e001664
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2017;37(3):534-542
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Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2017;69(7):823-836
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Journal article: INFLAMMATORY BOWEL DISEASES. 2017;23(suppl_1):s98
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Article: CIRCULATION RESEARCH. 2017;120(2):341-353
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Article: GENOME BIOLOGY. 2016;17(1):247
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Journal article: CIRCULATION. 2016;134(suppl_1)
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Article: G3-GENES GENOMES GENETICS. 2016;6(10):3361-3371
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Article: SCIENCE. 2016;353(6301):827-830
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Article: NATURE COMMUNICATIONS. 2016;7:12092
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2016;36(6):1240-1246
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Article: CELL SYSTEMS. 2016;2(3):196-208
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(10):2207-2217
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Article: ATHEROSCLEROSIS. 2015;239(2):528-538
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Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2015;8(2):305-315
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2014;34(9):2068-2077
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Article: PLOS GENETICS. 2014;10(2):e1004201
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Article: BMC BIOINFORMATICS. 2014;15:11
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Article: CELL CYCLE. 2014;13(23):3645-3658
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Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2011;28(2):247-253
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Article: INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE. 2011;27(6):851-857
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Journal article: [TITLE FIELD MISSING]. 2011;12(1):64
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Article: PLOS ONE. 2011;6(4):e18248
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Article: METABOLISM-CLINICAL AND EXPERIMENTAL. 2011;60(1):114-120
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Journal article: JOURNAL OF LIPIDS. 2011;2011:271062-9
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2010;30(5):962-967
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Article: IET SYSTEMS BIOLOGY. 2009;3(4):219-228
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Article: NATURE GENETICS. 2009;41(5):553-562
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Article: IET SYSTEMS BIOLOGY. 2009;3(2):113-123
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Article: BMC BIOINFORMATICS. 2009;10:38
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Article: JOURNAL OF MACHINE LEARNING RESEARCH. 2009;10:1071-1094
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Article: BIOINFORMATICS AND BIOLOGY INSIGHTS. 2008;2:307-316
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Article: LIPIDS. 2008;43(7):673-679
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Article: LIPIDS. 2008;43(4):353-360
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Article: PLOS GENETICS. 2008;4(3):e1000036
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Article: ATHEROSCLEROSIS. 2008;196(2):514-522
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Article: PLOS ONE. 2008;3(11):e3771
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Article: CLINICAL ENDOCRINOLOGY. 2008;68(1):51-58
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Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(34):13768-13773
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Article: BMC BIOINFORMATICS. 2007;8:150
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Article: JOURNAL OF MACHINE LEARNING RESEARCH. 2007;8:589-612
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Article: GENOMICS. 2006;88(2):133-142
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Article: PLOS GENETICS. 2006;2(5):755-761
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Article: BMC BIOINFORMATICS. 2006;7:51
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Article: CURRENT ATHEROSCLEROSIS REPORTS. 2006;8(1):1-2
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Article: PATTERN RECOGNITION LETTERS. 2005;26(14):2295-2308
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Article: CLINICAL CHEMISTRY. 2005;51(5):911-913
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Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2005;45(7):1013-1017
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Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2004;12(9):770-774
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(2):831-836
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2002;22(9):1470-1474
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(7):5476-5483
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(42):38511-38517
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(11):7515-7520
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Article: CIRCULATION. 1999;100(7):723-728
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Article: JOURNAL OF CLINICAL INVESTIGATION. 1999;103(9):1287-1298
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Article: JOURNAL OF LIPID RESEARCH. 1998;39(7):1412-1420
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Article: JOURNAL OF LIPID RESEARCH. 1998;39(2):423-436
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Article: JOURNAL OF LIPID RESEARCH. 1997;38(2):301-314
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Article: JOURNAL OF LIPID RESEARCH. 1996;37(1):76-86
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Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 1995;15(2):199-207
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Alla övriga publikationer
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Preprint: BIORXIV. 2023;BIORXIV
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Preprint: MEDRXIV. 2023;MEDRXIV
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Preprint: BIORXIV. 2023;BIORXIV
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Corrigendum: NATURE GENETICS. 2022;54(8):1259
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Preprint: BIORXIV. 2022
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Review: CELL. 2022;185(10):1630-1645
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Corrigendum: BASIC RESEARCH IN CARDIOLOGY. 2022;117(1):19
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Review: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2021;77(20):2531-2550
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Meeting abstract: FASEB JOURNAL. 2021;35
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Conference publication: ATHEROSCLEROSIS. 2021;331:E214-E215
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Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):4493
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Corrigendum: BMC MEDICAL GENOMICS. 2019;12(1):154
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Published conference paper: BMC MEDICAL GENOMICS. 2019;12(Suppl 6):108
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Corrigendum: NATURE GENETICS. 2019;51(7):1192-1193
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Book chapter: CAP-ANALYSIS GENE EXPRESSION (CAGE). 2019;p. 153-168
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Meeting abstract: BIOLOGICAL PSYCHIATRY. 2019;85(10):s98
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Review: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2018;72(18):2181-2197
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Meeting abstract: HEART. 2018;104:A71
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Review: NATURE REVIEWS CARDIOLOGY. 2018;15(1):9-19
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Conference publication: EUROPEAN HEART JOURNAL. 2018;39:1399
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Conference publication: EUROPEAN HEART JOURNAL. 2018;39:389-390
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Preprint: BIORXIV. 2017
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Review: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2017;2(3):311-327
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Editorial comment: CELL SYSTEMS. 2017;4(1):7-15
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Conference publication: INFLAMMATORY BOWEL DISEASES. 2017;23:S98
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Review: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2016;67(14):1725-1737
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Review: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2015;65(8):830-845
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Conference publication: ATHEROSCLEROSIS. 2014;235(2):E29
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Preprint: ARXIV. 2012
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Review: SCIENCE TRANSLATIONAL MEDICINE. 2012;4(115):115rv1
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Editorial comment: GENOME MEDICINE. 2012;4(3):29
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Conference publication: ATHEROSCLEROSIS SUPPLEMENTS. 2011;12(1):64
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Published conference paper: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 2009;1158:265-275
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Conference publication: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2009;7:598
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Review: LAKARTIDNINGEN. 2007;104(42):3042-3045
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Published conference paper: INTERNATIONAL JOURNAL OF APPROXIMATE REASONING. 2007;45(2):211-232
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Review: JOURNAL OF LIPID RESEARCH. 2007;48(2):267-277
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Review: TRENDS IN GENETICS. 2007;23(1):34-41
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Book chapter: ADVANCES IN PROBABILISTIC GRAPHICAL MODELS: STUDIES IN FUZZINESS AND SOFT COMPUTING. 2007;p. 359-375
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Published conference paper: CELLULAR IMMUNOLOGY. 2006;244(2):105-109
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):497-498
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):200-201
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2006;7(3):357
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Published conference paper: LECTURE NOTES IN COMPUTER SCIENCE. 2006;4212:719-726
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Published conference paper: BIOINFORMATICS. 2005;21 Suppl 2:ii224-ii229
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Published conference paper: LECTURE NOTES IN COMPUTER SCIENCE. 2005;3571:136-147
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Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):232
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Conference publication: ATHEROSCLEROSIS. 2003;170(1):S8
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Meeting abstract: ATHEROSCLEROSIS. 1999;144:124
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Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):286
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Meeting abstract: ATHEROSCLEROSIS. 1997;134(1-2):337
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Forskningsbidrag
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MIRACLEEuropean Union’s Horizon Europe (European Innovation Council)1 October 2023 - 1 October 2027
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Swedish Research Council1 January 2023 - 31 December 2026
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AtheroGenFondation Leducq1 January 2023 - 31 December 2026
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Swedish Heart-Lung Foundation1 January 2021 - 31 December 2023
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Swedish Research Council1 January 2019 - 31 December 2022
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Swedish Research Council1 January 2012 - 31 December 2014
Anställningar
- Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-
Examina och utbildning
- Docent, Molekylär medicin, Karolinska Institutet, 2003
- Läkarexamen, Karolinska Institutet, 1995