Johan Björkegren

Johan Björkegren

Senior Forskare | Docent
Besöksadress: Novum, Blickagången 6, 14157 Huddinge/Stockholm
Postadress: H7 Medicin, Huddinge, H7 ICCA Björkegren, 171 77 Stockholm
Del av:

Om mig

  • Med fokus på hjärt-kärlsjukdom är det övergripande målet med forskningen att generera och analysera multimodala och högdimensionella databaser för att från dessa beräkna fram robusta nätverk.

    Professor Genetics and Genomic Sciences, Department of Genetics and Genomic Sciences, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, New York (2013)

    Professor Medicine and Cardiology, Mount Sinai Hospital and the Cardiovascular Research Center of Icahn School of Medicine at Mount Sinai (2013)

    Associate Professor of Molecular Medicine, Karolinska Institutet, Stockholm, Sweden (2003)

    Visiting Professor, University of Tartu, Estland (2015) samt Tokyo College, Tokyo Univeristy, Japan (2024)

Utvalda publikationer

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • MIRACLE - European Union’s Horizon Europe (European Innovation Council
    European Union’s Horizon Europe (European Innovation Council)
    1 October 2023 - 1 October 2027
  • Swedish Research Council
    1 January 2023 - 31 December 2026
    Traditional research approaches of complex traits like cardiometabolic disorders (CMDs) and coronary artery disease (CAD) suffer from being too candidate gene- or pathway-focused, failing to capture the true complexity of these disorders. However with recent technology development allowing decephering regulatory mechanisms of gene expression in single cells, systems approches considering multiple layers  of omics data in disease-relevant tissues and cells responsible for the development of complex diseases can be considered. In Aim 1, we will take advantage of the world-leading, gender-diverse and data-rich STARNET study of 1,706 well-characterized patients with and without CAD, to perform multi-modal profiling using the combined single nuclei (sn)ATAC/snRNA sequencing together with bulk RNAseq in seven vascular and metabolic tissues. In Aim 2, we will infer multi-omic layered gene-regualtory networks (GRNs) and to these, apply deep learning modelling (“CADnet”) to identify and prioritize tissue- and cell-level gene-regulatory circuits driving CMDs and CAD. In Aim 3 by assessing heritability contributions and the potential of poly-genetic risk scores to predict CMDs/CAD, the clinical impact of CADnet prioritized gene-regulatory circuits will be evaluated in large-scale population studies. Our proposal holds strong potential to bring CMD and CAD understanding to a new systems, yet deeper, level, essentail for embarking on the promises of precision medicine.
  • AtheroGen - Fondation Leducq
    Fondation Leducq
    1 January 2023 - 31 December 2026
  • Swedish Heart-Lung Foundation
    1 January 2021 - 31 December 2023
  • PlaqueOmics: Novel Roles of Smooth Muscle and Other Matrix Producing Cells in Atherosclerotic Plaque Stability and Rupture
    Foundation Leducq
    1 January 2020 - 1 January 2025
  • Swedish Research Council
    1 January 2019 - 31 December 2022
  • Systems genetics to ...
    Hjärtlungfonden
    1 January 2018
  • National Institutes of Health R21
    National Institutes of Health
    1 January 2017 - 1 January 2019
  • National Institutes of Health -RO1
    National Institutes of Health
    1 January 2016 - 1 January 2020
  • 1 January 2015 - 1 January 2019
  • CADgenomics: Understanding CAD Genes, Leducq Foundation
    Transatalantic Network, the Leducq Foundation
    1 January 2014 - 1 January 2017
  • CVgenes@target -FP7 European Commission Integrated project
    FP7 -European Commission Integrated project
    1 January 2014 - 1 January 2017
  • American Heart Association - Family-Based Approach in a Minority Community Integrating Systems–Biology for Promotion of Health (FAMILIA)
    American Heart Association
    1 January 2014 - 1 January 2018
  • A systems cardiovascular approach....
    Hjärtlungfonden
    1 January 2013
  • Karolinska-AstraZeneca Center for Translation Science
    Karolinska Astra-Zeneca Center for Translation Science
    1 January 2013 - 1 January 2016
  • Swedish Research Council
    1 January 2012 - 31 December 2014
  • Center for Translation Genomics, University of Tartu
    Center for translation genomics, University of Tartu
    1 January 2012 - 1 January 2015
  • Gene-regulatory networks in CAD
    Hjärtlungfonden
    1 January 2010
  • Studier av LIM Domain Binding 2 i ateroskleros
    Vetenskapsrdet
    1 January 2008
  • The role of LIM-binding domain 2 in atherosclerosis
    Hjärtlungfonden
    1 January 2008
  • Visa fler

Anställningar

  • Senior Forskare, Medicin, Huddinge, Karolinska Institutet, 2022-
  • Professor, Genetik och Genomik, Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, 2013-2023
  • Professor, Medicin-kardiologi, Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2013-2023
  • Klinisk forskningschef, Klinisk systemgenetik, Icahn Institute for Genomics and Multiscale Biology, Icahn School of Medicine at Mount Sinai, 2013-2020

Examina och utbildning

  • Docent, Molekylär medicin, Karolinska Institutet, 2003
  • Doktor, Doktorsexamen, Postprandial triglyceride-rich lipoproteins and atherosclerosis, Medicine, Solna, Karolinska Institutet, 1998
  • Läkarexamen, Karolinska Institutet, 1995
  • Civilekonom, Business School, Stockholm University, 1989

Uppdrag

  • Forskargruppsledare, Forskargrupp, Karolinska Institutet, 2017-
  • Programdirektor, Systemgenetiska kliniska studier, Department of Genetics and Genomic Sciences, Cardiovascular Research Center, Icahn School of Medicine at Mount Sinai, 2013-2020
  • VD och styrelseordförande, Clinical Gene Networks AB, Clinical Gene Networks (Sweden), http://clinicalgenenetworks.com/, 2003-

Priser och utmärkelser

  • Visiting Professor at Tokyo College, University of Tokyo, 2024
  • Senior investigator award, Swedish Heart-Lung Foundation, 2010
  • Senior investigator award, Karolinska Institutet, 2008
  • FoAss, Swedish Research Council, 2004
  • Finalist in the Young Investigator Award, International Society of Atherosclerosis, 2003
  • Fogarty fellowship, University of San Francisco, 1999

Uppdrag i kommitté

  • Medlem, Affymetrix Inc/Karolinska Institutet collaboration, Karolinska Institutet, 2005-
  • Medlem, Tillgång till biobanksprover och tillhörande information-principer och praktiska tillämpningar, Karolinska Institutet, 2005-2006
  • Ordförande, Examination committees for PhD theses, Karolinska Institutet, 2003-2012

Gästforskning och resestipendier

  • Postdoc, Gladstone Institutes, Post-doc using mouse models of atherosclerosis and cardiometabolic diseases, 1999-2001

Utvärdering av avhandlingsarbete

  • Katharina Slätis, Opponent, Institutionen för Medicin, Karolinska Institutet, 2009
  • Margareta Jernås, Opponent, Sahlgrenska University Hospital, 2008

Expert

  • Evaluator of research applications in international competition, External Evaluator, Danish Council for Strategic Research, 2008-2013
  • Evaluator of research applications in international competition, External Evaluator, European Science Foundation, 2008-2013
  • Reviewer or advisor for other scientific bodies, Scientific Evaluator, University of Tromsö, 2003

Nyheter från KI

Kalenderhändelser från KI

Nyheter från externa medier

Presentationer

  • Presentation (slides etc.): 2022
    Invited speaker to the Finnish Atherosclerosis Society (SATY). Title: STARNET- A World-Leading Functional Database for Studies of Cardiometabolic Disorders and Coronary Artery Disease.
    Björkegren J
  • Presentation (slides etc.): 2020
    Plenary speaker, European Atherosclerosis Society (EAS). Title: Implementing systems biology to personalize medicine.
    Björkegren J
  • Presentation (slides etc.): 2020
    Invited speaker to Columbia University, Cardiovascular Seminar Series. Title: A systems medicine approach to unravel key disease network drivers and biomarkers in cardiometabolic and coronary artery disease
    Björkegren J
  • Presentation (slides etc.): 2020
    Inivited keynote speaker, The 1st International Symposium on Human InformatiX. Title: A systems medicine approach to unravel key disease network drivers and biomarkers in cardiometabolic and coronary artery disease
    Björkegren J
  • Presentation (slides etc.): 2019
    Riskgener som driver åderförkalkning - ett gennätverks perspektiv, Temadag Kolesterol och Åderförkalkning, Karolinska Institutet
    Björkegren J
  • Presentation (slides etc.): 2018
    Invited Keynote speaker, GENMED workshop. “From GWAS to genetically regulated tissue-specified coding and non-coding genes in CAD-causal networks and pathways – a Systems Genetics Approach”
    Björkegren J
  • Presentation (slides etc.): 2018
    Invited Keynote speaker, Keystone Symposium of Atherosclerosis. “Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases”
    Björkegren J
  • Presentation (slides etc.): 2018
    Invited Keynote speaker, 10 years of GWAS, Looking back – looking forward. Title: “Systems genetic approaches to coronary artery disease”
    Björkegren J
  • Presentation (slides etc.): 2016
    Invited speaker and chair at the 6th Conference on Systems Biology of the Mammalian Cells. Title of talk “Systems Genetic Approaches to Coronary Artery Disease - Toward Diagnostics and Therapies of Molecularly Defined Subcategories of Patients”,
    Björkegren J
  • Presentation (slides etc.): 2016
    Invited speaker EBRC SEMINAR- THE ROSLIN INSTITUTE “Systems Genetic Approaches to Coronary Artery Disease Towards Diagnostics and Therapies of Patients in Molecularly Defined Subcategories”.
    Björkegren J
  • Presentation (slides etc.): 2015
    Invited speaker and part of the Expert Panel Advisory Board for the HIGH SCIENCE HDL FORUM: THE ROLE OF HDL MODIFYING THERAPY FOR THE PREVENTION OF CARDIOVASCULAR DISEASE Title of the talk: “Systems Biology in the evaluation of genetically determined risk”
    Björkegren J
  • Presentation (slides etc.): 2013
    Invited speaker to the Symposium - Genetics of Atherosclerosis - Update 2013
    Björkegren J
  • Presentation (slides etc.): 2012
    Invited keynote speaker at the conference “Complex Traits: Genomics and Computational Approaches”, Keystone Conference (B5)
    Björkegren J
  • Presentation (slides etc.): 2012
    Invited speaker at the conference GeneForum
    Björkegren J
  • Presentation (slides etc.): 2010
    Invited keynote speaker at the “Advances in Molecular Mechanisms of Atherosclerosis (J7)” organized by the Keystone Conferences organization
    Björkegren J
  • Presentation (slides etc.): 2009
    Invited speaker to the “Genetics and Genomics of Cardiovascular Disease Workshop” organized by the North American Vascular Biology Organization (NAVBO)
    Björkegren J
  • Presentation (slides etc.): 2008
    Program Committee of the International Conference on Systems Biology (ICSB). Moderator of workshop on Cardiovascular Systems Biology
    Björkegren J
  • Presentation (slides etc.): 2008
    Organizer and keynote speaker, ESF Exploratory Workshop on Computational Disease Modeling
    Björkegren J
  • Presentation (slides etc.): 2004
    Speaker at the XV International Symposium on Drugs Affecting Lipid Metabolism
    Björkegren J
  • Presentation (slides etc.): 2003
    Atheroma Club 1992-2006
    Björkegren J
  • Presentation (slides etc.): 2003
    Speaker at the International Symposium on Atherosclerosis
    Björkegren J
  • Presentation (slides etc.): 2002
    Invited speaker to the British Atherosclerosis Society
    Björkegren J
  • Presentation (slides etc.): 2002
    Speaker at the 42nd Annual Conference on Cardiovascular Disease Epidemiology and Prevention
    Björkegren J
  • Presentation (slides etc.): 2002
    Speaker at the Annual Scandinavian Atherosclerosis Conference, 2002, 2003, 2204
    Björkegren J
  • Presentation (slides etc.): 1998
    Invited speaker to European Lipoprotein Club 1998, 2001
    Björkegren J
  • Presentation (slides etc.): 1998
    Speaker at the International Symposium on Atherosclerosis (IAS)
    Björkegren J