Jesper Z. Haeggström

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: AMERICAN JOURNAL OF HEMATOLOGY. 2023;98(7):1000-1016
Stereochemistry and functions of the new cysteinyl-resolvin, 4S,5R-RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes
Nshimiyimana R; Libreros S; Simard M; Chiang N; Rodriguez AR; Spur BW; Haeggstrom JZ; Serhan CN
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2023;24(8):7539
Modulation of the 5-Lipoxygenase Pathway by Chalcogen-Containing Inhibitors of Leukotriene A₄ Hydrolase
Teder T; Koenig S; Singh R; Samuelsson B; Werz O; Garscha U; Haeggstrom JZ
Article: JOURNAL OF LIPID RESEARCH. 2022;63(12):100310
Biosynthesis of prostaglandin 15dPGJ₂ -glutathione and 15dPGJ₂-cysteine conjugates in macrophages and mast cells via MGST3
Steinmetz-Spah J; Liu J; Singh R; Ekoff M; Boddul S; Tang X; Bergqvist F; Idborg H; Heitel P; Ronnberg E; Merk D; Wermeling F; Haeggstrom JZ; Nilsson G; Steinhilber D; Larsson K; Korotkova M; Jakobsson P-J
Article: ALLERGY. 2022;77(9):2677-2687
Activation of succinate receptor 1 boosts human mast cell reactivity and allergic bronchoconstriction
Tang X; Ronnberg E; Safholm J; Thulasingam M; Trauelsen M; Schwartz TW; Wheelock CE; Dahlen S-E; Nilsson G; Haeggstrom JZ
Article: FRONTIERS IN PHARMACOLOGY. 2022;13:806240
The IRE1α Inhibitor KIRA6 Blocks Leukotriene Biosynthesis in Human Phagocytes
Tang X; Teder T; Samuelsson B; Haeggstrom JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2116559118
Human leukocytes selectively convert 4S,5S-epoxy-resolvin to resolvin D3, resolvin D4, and a cys-resolvin isomer
Shay AE; Nshimiyimana R; Samuelsson B; Petasis NA; Haeggstrom JZ; Serhan CN
Article: NATURE COMMUNICATIONS. 2021;12(1):1728
Crystal structures of human MGST2 reveal synchronized conformational changes regulating catalysis
Thulasingam M; Orellana L; Nji E; Ahmad S; Rinaldo-Matthis A; Haeggstrom JZ
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2020;33(9):2420-2431
Investigation of Clozapine and Olanzapine Reactive Metabolite Formation and Protein Binding by Liquid Chromatography-Tandem Mass Spectrometry.
Geib T; Thulasingam M; Haeggström JZ; Sleno L
Article: MOLECULAR ASPECTS OF MEDICINE. 2020;:100893
WITHDRAWN: The Atlas of Inflammation Resolution (AIR).
Serhan CN; Gupta SK; Perretti M; Godson C; Brennan E; Li Y; Soehnlein O; Shimizu T; Werz O; Chiurchiù V; Azzi A; Dubourdeau M; Gupta SS; Schopohl P; Hoch M; Gjorgevikj D; Khan FM; Brauer D; Tripathi A; Cesnulevicius K; Lescheid D; Schultz M; Särndahl E; Repsilber D; Kruse R; Sala A; Haeggström JZ; Levy BD; Filep JG; Wolkenhauer O
Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2020;18(4):976-984
Activation of metabolite receptor GPR91 promotes platelet aggregation and transcellular biosynthesis of leukotriene C₄
Tang X; Fuchs D; Tan S; Trauelsen M; Schwartz TW; Wheelock CE; Li N; Haeggstrom JZ
Article: FASEB JOURNAL. 2019;33(12):13794-13807
Biosynthetic metabolomes of cysteinyl-containing immunoresolvents
Jouvene CC; Shay AE; Soens MA; Norris PC; Haeggstrom JZ; Serhan CN
Article: CELL CHEMICAL BIOLOGY. 2019;26(4):524-534.e5
Gliotoxin from Aspergillus fumigatus Abrogates Leukotriene B₄ Formation through Inhibition of Leukotriene A₄ Hydrolase
Koenig S; Pace S; Pein H; Heinekamp T; Kramer J; Romp E; Strassburger M; Troisi F; Proschak A; Dworschak J; Scherlach K; Rossi A; Sautebin L; Haeggstrom JZ; Hertweck C; Brakhage AA; Gerstmeier J; Proschak E; Werz O
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2018;139:24-28
Targeting cysteinyl-leukotrienes in abdominal aortic aneurysm
Araujo AC; Tang X; Haeggstrom JZ
Article: FASEB JOURNAL. 2018;32(5):2827-2840
Prostaglandin E₂ suppresses hCAP18/LL-37 expression in human macrophages via EP2/EP4: implications for treatment of Mycobacterium tuberculosis infection
Wan M; Tang X; Rekha RS; Muvva SSVJR; Brighenti S; Agerberth B; Haeggstrom JZ
Article: INTERNATIONAL JOURNAL FOR PARASITOLOGY-DRUGS AND DRUG RESISTANCE. 2018;8(1):31-35
Potential role of Plasmodium falciparum exported protein 1 in the chloroquine mode of action
Lisewski AM; Quiros JP; Mittal M; Putluri N; Sreekumar A; Haeggstrom JZ; Lichtarge O
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(8):1907-1912
Cysteinyl leukotriene receptor 1 antagonism prevents experimental abdominal aortic aneurysm
Di Gennaro A; Araujo AC; Busch A; Jin H; Wagsater D; Vorkapic E; Caidahl K; Eriksson P; Samuelsson B; Maegdefessel L; Haeggstrom JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(36):9689-9694
Capturing LTA₄ hydrolase in action: Insights to the chemistry and dynamics of chemotactic LTB₄ synthesis
Stsiapanava A; Samuelsson B; Haeggstrom JZ
Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2017;1861(8):2099-2111
Investigation of calcium-dependent activity and conformational dynamics of zebra fish 12-lipoxygenase
Mittal M; Hasan M; Balagunaseelan N; Fauland A; Wheelock C; Radmark O; Haeggstrom JZ; Rinaldo-Matthis A
Article: SCIENTIFIC REPORTS. 2016;6:38316
Catalytic Conversion of Lipophilic Substrates by Phase constrained Enzymes in the Aqueous or in the Membrane Phase
Cebula M; Turan IS; Sjodin B; Thulasingam M; Brock J; Chmyrov V; Widengren J; Abe H; Mannervik B; Haeggstrom JZ; Rinaldo-Matthis A; Akkaya EU; Morgenstern R
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1861(11):1605-1613
Development of smart cell-free and cell-based assay systems for investigation of leukotriene C₄ synthase activity and evaluation of inhibitors
Liening S; Scriba GK; Rummler S; Weinigel C; Kleinschmidt TK; Haeggstrom JZ; Werz O; Garscha U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2016;291(35):18410-18418
Phosphorylation of Leukotriene C₄ Synthase at Serine 36 Impairs Catalytic Activity
Ahmad S; Ytterberg AJ; Thulasingam M; Tholander F; Bergman T; Zubarev R; Wetterholm A; Rinaldo-Matthis A; Haeggstrom JZ
Article: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 2016;26(15):3547-3551
Kinetic investigation of human 5-lipoxygenase with arachidonic acid
Mittal M; Kumar RB; Balagunaseelan N; Hamberg M; Jegerschold C; Radmark O; Haeggstrom JZ; Rinaldo-Matthis A
Article: FASEB JOURNAL. 2016;30(2):884-894
Cathelicidins positively regulate pancreatic β-cell functions
Sun J; Xu M; Ortsater H; Lundeberg E; Juntti-Berggren L; Chen YQ; Haeggstrom JZ; Gudmundsson GH; Diana J; Agerberth B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2016;113(4):972-977
A dynamic Asp-Arg interaction is essential for catalysis in microsomal prostaglandin E₂ synthase
Brock JS; Hamberg M; Balagunaseelan N; Goodman M; Morgenstern R; Strandback E; Samuelsson B; Rinaldo-Matthis A; Haeggstrom JZ
Article: FASEB JOURNAL. 2015;29(12):5029-5043
Lipoxin and resolvin biosynthesis is dependent on 5-lipoxygenase activating protein
Lehmann C; Homann J; Ball A-K; Bloecher R; Kleinschmidt TK; Basavarajappa D; Angioni C; Ferreiros N; Haefner A-K; Radmark O; Proschak E; Haeggstrom JZ; Geisslinger G; Parnham MJ; Steinhilber D; Kahnt AS
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(10):1365-1371
Trimeric microsomal glutathione transferase 2 displays one third of the sites reactivity
Ahmad S; Thulasingam M; Palombo I; Daley DO; Johnson KA; Morgenstern R; Haeggstrom JZ; Rinaldo-Matthis A
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 2015;355(1):108-116
Tandem Benzophenone Amino Pyridines, Potent and Selective Inhibitors of Human Leukotriene C₄ Synthases
Kleinschmidt TK; Haraldsson M; Basavarajappa D; Lundeberg E; Thulasingam M; Ekoff M; Fauland A; Lehmann C; Kahnt AS; Lindbom L; Haeggstrom JZ
Article: MULTIPLE SCLEROSIS JOURNAL. 2015;21(10):1271-1279
Hexosylceramides as intrathecal markers of worsening disability in multiple sclerosis
Checa A; Khademi M; Sar DG; Haeggstroem JZ; Lundberg JO; Piehl F; Olsson T; Wheelock CE
Article: JOURNAL OF IMMUNOLOGY. 2015;195(3):1191-1201
P2X₇ Receptor Regulates Internalization of Antimicrobial Peptide LL-37 by Human Macrophages That Promotes Intracellular Pathogen Clearance
Tang X; Basavarajappa D; Haeggstrom JZ; Wan M
Article: SCIENTIFIC REPORTS. 2015;5:12017
Circulating levels of sphingosine-1-phosphate are elevated in severe, but not mild psoriasis and are unresponsive to anti-TNF-α treatment
Checa A; Xu N; Sar DG; Haeggstrom JZ; Stahle M; Wheelock CE
Article: NATURE NEUROSCIENCE. 2015;18(1):145-153
Unbiased classification of sensory neuron types by large-scale single-cell RNA sequencing
Usoskin D; Furlan A; Islam S; Abdo H; Lonnerberg P; Lou D; Hjerling-Leffler J; Haeggstrom J; Kharchenko O; Kharchenko PV; Linnarsson S; Ernfors P
Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2014;7(6):955-964
High-Dose Simvastatin Exhibits Enhanced Lipid-Lowering Effects Relative to Simvastatin/Ezetimibe Combination Therapy
Snowden SG; Grapov D; Settergren M; D'Alexandri FL; Haeggstrom JZ; Fiehn O; Hyotylainen T; Pedersen TL; Newman JW; Oresic M; Pernow J; Wheelock CE
Article: ATHEROSCLEROSIS. 2014;235(2):592-598
Oxidized but not native cardiolipin has pro-inflammatory effects, which are inhibited by Annexin A5
Wan M; Hua X; Su J; Thiagarajan D; Frostegard AG; Haeggstrom JZ; Frostegard J
Article: FASEB JOURNAL. 2014;28(8):3456-3467
Cathelicidin LL-37 induces time-resolved release of LTB₄ and TXA₂ by human macrophages and triggers eicosanoid generation in vivo
Wan M; Soehnlein O; Tang X; van der Does AM; Smedler E; Uhlen P; Lindbom L; Agerberth B; Haeggstrom JZ
Article: JOURNAL OF LEUKOCYTE BIOLOGY. 2014;95(6):971-981
Antimicrobial peptide LL-37 promotes bacterial phagocytosis by human macrophages
Wan M; van der Does AM; Tang X; Lindbom L; Agerberth B; Haeggstrom JZ
Article: AMINO ACIDS. 2014;46(5):1313-1320
A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.
Byzia A; Haeggström JZ; Salvesen GS; Drag M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(11):4227-4232
Binding of Pro-Gly-Pro at the active site of leukotriene A₄ hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor
Stsiapanava A; Olsson U; Wan M; Kleinschmidt T; Rutishauser D; Zubarev RA; Samuelsson B; Rinaldo-Matthis A; Haeggstrom JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(8):5199-5207
Crystal Structures of Leukotriene C₄ Synthase in Complex with Product Analogs
Niegowski D; Kleinschmidt T; Olsson U; Ahmad S; Rinaldo-Matthis A; Haeggstrom JZ
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2014;1844(2):439-446
Product formation controlled by substrate dynamics in leukotriene A4 hydrolase
Stsiapanava A; Tholander F; Kumar RB; Qureshi AA; Niegowski D; Hasan M; Thunnissen M; Haeggstrom JZ; Rinaldo-Matthis A
Article: PLOS ONE. 2014;9(5):e96763
Structure and Inhibition of Mouse Leukotriene C₄ Synthase
Niegowski D; Kleinschmidt T; Ahmad S; Qureshi AA; Marback M; Rinaldo-Matthis A; Haeggstrom JZ
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2013;106:72-78
Annexin A5 inhibits atherogenic and pro-inflammatory effects of lysophosphatidylcholine
Domeij H; Hua X; Su J; Backlund A; Yan Z; Frostegard AG; Haeggstrom JZ; Modeer T; Frostegard J
Article: MOLECULAR NUTRITION & FOOD RESEARCH. 2013;57(8):1378-1389
Lipid mediator serum profiles in asthmatics significantly shift following dietary supplementation with omega-3 fatty acids
Lundstrom SL; Yang J; Brannan JD; Haeggstrom JZ; Hammock BD; Nair P; O'Byrne P; Dahlen S-E; Wheelock CE
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2013;33(8):1965-1972
Cathelicidin LL-37 Induces Angiogenesis via PGE₂-EP3 Signaling in Endothelial Cells, In Vivo Inhibition by Aspirin
Salvado MD; Di Gennaro A; Lindbom L; Agerberth B; Haeggstrom JZ
Article: FASEB JOURNAL. 2013;27(7):2573-2583
The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A₄ hydrolase (LTA₄H), and shifts macrophage phenotype
Dalli J; Zhu M; Vlasenko NA; Deng B; Haeggstrom JZ; Petasis NA; Serhan CN
Article: BIOCHEMISTRY. 2013;52(10):1755-1764
Catalytic Characterization of Human Microsomal Glutathione S-Transferase 2: Identification of Rate-Limiting Steps
Ahmad S; Niegowski D; Wetterholm A; Haeggstrom JZ; Morgenstern R; Rinaldo-Matthis A
Article: ALLERGY. 2013;68(3):304-311
The antimicrobial peptide LL-37 induces synthesis and release of cysteinyl leukotrienes from human eosinophils implications for asthma
Sun J; Dahlen B; Agerberth B; Haeggstrom JZ
Article: JOURNAL OF LIPID RESEARCH. 2013;54(1):116-126
Lipid mediator metabolic profiling demonstrates differences in eicosanoid patterns in two phenotypically distinct mast cell populations
Lundstrom SL; Saluja R; Adner M; Haeggstrom JZ; Nilsson G; Wheelock CE
Article: BIOCHEMISTRY. 2012;51(4):848-856
Pre-Steady-State Kinetic Characterization of Thiolate Anion Formation in Human Leukotriene C₄ Synthase
Rinaldo-Matthis A; Ahmad S; Wetterholm A; Lachmann P; Morgenstern R; Haeggstrom JZ
Article: PLOS ONE. 2012;7(3):e33780
Allergic Asthmatics Show Divergent Lipid Mediator Profiles from Healthy Controls Both at Baseline and following Birch Pollen Provocation
Lundstrom SL; Yang J; Kallberg HJ; Thunberg S; Gafvelin G; Haeggstrom JZ; Gronneberg R; Grunewald J; van Hage M; Hammock BD; Eklund A; Wheelock AM; Wheelock CE
Article: PLOS ONE. 2012;7(7):e41786
Cysteinyl Leukotriene Signaling Aggravates Myocardial Hypoxia in Experimental Atherosclerotic Heart Disease
Nobili E; Salvado MD; Folkersen L; Castiglioni L; Kastrup J; Wetterholm A; Tremoli E; Hansson GK; Sironi L; Haeggstrom JZ; Gabrielsen A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(51):20479-20484
Targeted knock-down of a structurally atypical zebrafish 12S-lipoxygenase leads to severe impairment of embryonic development
Haas U; Raschperger E; Hamberg M; Samuelsson B; Tryggvason K; Haeggstrom JZ
Article: FASEB JOURNAL. 2011;25(5):1697-1705
Leukotriene B₄/antimicrobial peptide LL-37 proinflammatory circuits are mediated by BLT1 and FPR2/ALX and are counterregulated by lipoxin A₄ and resolvin E1
Wan M; Godson C; Guiry PJ; Agerberth B; Haeggstrom JZ
Article: ATHEROSCLEROSIS. 2011;215(2):411-416
12-and 15-lipoxygenases in human carotid atherosclerotic lesions: Associations with cerebroyascular symptoms
Gertow K; Nobili E; Folkersen L; Newman JW; Pedersen TL; Ekstrand J; Swedenborg J; Kuehn H; Wheelock CE; Hansson GK; Hedin U; Haeggstrom JZ; Gabrielsen A
Article: FASEB JOURNAL. 2011;25(4):1417-1427
Zymosan suppresses leukotriene C₄ synthase activity in differentiating monocytes: antagonism by aspirin and protein kinase inhibitors
Esser J; Gehrmann U; Salvado MD; Wetterholm A; Haeggstrom JZ; Samuelsson B; Gabrielsson S; Scheynius A; Radmark O
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2011;84(3-4):109-112
Commonly used leukotriene B₄ receptor antagonists possess intrinsic activity as agonists in human endothelial cells: Effects on calcium transients, adhesive events and mediator release
Johansson A-S; Haeggstrom JZ; Palmblad J
Article: JOURNAL OF MOLECULAR BIOLOGY. 2011;406(1):120-134
A Leukotriene A₄ Hydrolase-Related Aminopeptidase from Yeast Undergoes Induced Fit upon Inhibitor Binding
Helgstrand C; Hasan M; Uysal H; Haeggstrom JZ; Thunnissen MMGM
Article: PLOS ONE. 2011;6(8):e23864
Asthmatics Exhibit Altered Oxylipin Profiles Compared to Healthy Individuals after Subway Air Exposure
Lundstrom SL; Levanen B; Nording M; Klepczynska-Nystrom A; Skold M; Haeggstrom JZ; Grunewald J; Svartengren M; Hammock BD; Larsson B-M; Eklund A; Wheelock AM; Wheelock CE
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(52):40771-40776
Arginine 104 Is a Key Catalytic Residue in Leukotriene C₄ Synthase
Rinaldo-Matthis A; Wetterholm A; Molina DM; Holm J; Niegowski D; Ohlson E; Nordlund P; Morgenstern R; Haeggstrom JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(49):21093-21097
Increased expression of leukotriene C₄ synthase and predominant formation of cysteinyl-leukotrienes in human abdominal aortic aneurysm
Di Gennaro A; Wagsater D; Mayranpaa MI; Gabrielsen A; Swedenborg J; Hamsten A; Samuelsson B; Eriksson P; Haeggstrom JZ
Article: EXPERIMENTAL CELL RESEARCH. 2010;316(17):2790-2796
Subcellular localization of leukotriene receptors in human endothelial cells
Johansson A-S; Haeggstrom JZ; Hultenby K; Palmblad J
Article: FEBS LETTERS. 2010;584(15):3446-3451
Crystal structure of leukotriene A₄ hydrolase in complex with kelatorphan, implications for design of zinc metallopeptidase inhibitors
Tholander F; Rogues B-P; Fournie-Zaluski M-C; Thunnissen MMGM; Haeggstrom JZ
Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2010;88(8):795-806
Thromboxane synthase expression and thromboxane A₂ production in the atherosclerotic lesion
Gabrielsen A; Qiu H; Back M; Hamberg M; Hemdahl A-L; Agardh H; Folkersen L; Swedenborg J; Hedin U; Paulsson-Berne G; Haeggstrom JZ; Hansson GK
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):135-139
Advances in eicosanoid research, novel therapeutic implications
Haeggstrom JZ; Rinaldo-Matthis A; Wheelock CE; Wetterholm A
Article: BIOINFORMATICS. 2009;25(15):1978-1979
GeneRegionScan: a Bioconductor package for probe-level analysis of specific, small regions of the genome
Folkersen L; Diez D; Wheelock CE; Haeggstrom JZ; Goto S; Eriksson P; Gabrielsen A
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2009;29(7):1131-1137
COX-2 Limits Prostanoid Production in Activated HUVECs and Is a Source of PGH₂ for Transcellular Metabolism to PGE₂ by Tumor Cells
Dolores Salvado M; Alfranca A; Escolano A; Haeggstrom JZ; Miguel Redondo J
Article: FASEB JOURNAL. 2009;23(6):1750-1757
Leukotriene B₄-induced changes in vascular permeability are mediated by neutrophil release of heparin-binding protein (HBP/CAP37/azurocidin)
Di Gennaro A; Kenne E; Wan M; Soehnlein O; Lindbom L; Haeggstrom JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(1):301-305
Mutation of a Critical Arginine in Microsomal Prostaglandin E Synthase-1 Shifts the Isomerase Activity to a Reductase Activity That Converts Prostaglandin H₂ into Prostaglandin F_2α
Hammarberg T; Hamberg M; Wetterholm A; Hansson H; Samuelsson B; Haeggstrom JZ
Article: METHODS IN MOLECULAR BIOLOGY. 2009;579:161-187
HPLC/MS/MS-based approaches for detection and quantification of eicosanoids.
Lundström SL; D'Alexandri FL; Nithipatikom K; Haeggström JZ; Wheelock AM; Wheelock CE
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2008;1784(11):1865-1872
Cold adaptation of enzymes: Structural, kinetic and microcalorimetric characterizations of an aminopeptidase from the Arctic psychrophile Colwellia psychrerythraea and of human leukotriene A₄ hydrolase
Huston AL; Haeggstrom JZ; Feller G
Article: FASEB JOURNAL. 2008;22(10):3525-3536
Expression of enzymes and receptors of the leukotriene pathway in human neuroblastoma promotes tumor survival and provides a target for therapy
Sveinbjornsson B; Rasmuson A; Baryawno N; Wan M; Pettersen I; Ponthan F; Orrego A; Haeggstrom JZ; Johnsen JI; Kogner P
Article: CHEMISTRY AND BIOLOGY. 2008;15(9):920-929
Structure-Based Dissection of the Active Site Chemistry of Leukotriene A4 Hydrolase: Implications for M1 Aminopeptidases and Inhibitor Design
Tholander F; Muroya A; Roques B-P; Fournie-Zaluski M-C; Thunnissen MMGM; Haeggstrom JZ
Article: PROTEIN EXPRESSION AND PURIFICATION. 2008;60(1):1-6
High-level expression, purification, and crystallization of recombinant rat leukotriene C₄ synthase from the yeast Pichia pastoris
Wetterholm A; Molina DM; Nordlund P; Eshaghi S; Haeggstrom JZ
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2008;16(9):4963-4983
Synthesis of glutamic acid analogs as potent inhibitors of leukotriene A₄ hydrolase
Kirkland TA; Adler M; Bauman JG; Chen M; Haeggstrom JZ; King B; Kochanny MJ; Liang AM; Mendoza L; Phillips GB; Thunnissen M; Trinh L; Whitlow M; Ye B; Ye H; Parkinson J; Guilford WJ
Article: PROTEIN SCIENCE. 2008;17(4):673-680
Engineering membrane protein overproduction in Escherichia coli
Molina DM; Cornvik T; Eshaghi S; Haeggstrom JZ; Nordlund P; Sabet MI
Article: JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS. 2008;51(1-2):101-105
Preparation of high specific activity tritium-labelled leukotriene B₄ suitable for radioligand binding assay
Schramm SI; Nagaev IY; Sabirsh A; Shevchenko VP; Arkhipova AS; Haeggstrom JZ; Myasoedov NF
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2008;205(1):19-24
Human CMV infection induces 5-lipoxygenase expression and leukotriene B₄ production in vascular smooth muscle cells
Qiu H; Straat K; Rahbar A; Wan M; Soederberg-Naucler C; Haeggstroem JZ
Article: FASEB JOURNAL. 2007;21(11):2897-2905
Leukotriene B₄ triggers release of the cathelicidin LL-37 from human neutrophils:: novel lipid-peptide interactions in innate immune responses
Wan M; Sabirsh A; Wetterholm A; Agerberth B; Haeggstrom JZ
Article: NATURE. 2007;448(7153):613-616
Structural basis for synthesis of inflammatory mediators by human leukotriene C₄ synthase
Molina DM; Wetterholm A; Kohl A; McCarthy AA; Niegowski D; Ohlson E; Hammarberg T; Eshaghi S; Haeggstroem JZ; Nordlund P
Article: PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS. 2007;67(4):1113-1118
Assay for rapid analysis of the tri-peptidase activity of LTA₄ hydrolase
Tholander F; Haeggstrom JZ
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):209-212
Endothelium-dependent vascular responses induced by leukotriene B₄
Back M; Sakata K; Qiu H; Haeggstrom JZ; Dahlen S-E
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2007;83(3):198-202
Structure and catalytic mechanisms of leukotriene A₄ hydrolase
Haeggstrom JZ; Tholander F; Wetterholm A
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 2006;14(21):7241-7257
Synthesis and structure activity relationships of novel non-peptidic metallo-aminopeptidase inhibitors.
Albrecht S; Defoin A; Salomon E; Tarnus C; Wetterholm A; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(21):8161-8166
Expression of 5-lipoxygenase and leukotriene A₄ hydrolase in human atherosclerotic lesions correlates with symptoms of plaque instability
Qiu H; Gabrielsen A; Agardh HE; Wan M; Wetterholm A; Wong C-H; Hedin U; Swedenborg J; Hansson GK; Samuelsson B; Paulsson-Berne G; Haeggstrom JZ
Article: BIOCHEMISTRY. 2006;45(18):5733-5744
Residues from transmembrane helices 3 and 5 participate in leukotriene B4 binding to BLT1.
Sabirsh A; Bywater RP; Bristulf J; Owman C; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2006;103(18):6913-6918
Differential induction of BLT receptor expression on human endothelial cells by lipopolysacharide, cytokines, and leukotriene B₄
Qiu H; Johansson AS; Sjostrom M; Wan M; Schroder O; Palmblad J; Haeggstrom JZ
Article: JOURNAL OF LIPID RESEARCH. 2006;47(5):1071-1080
15-deoxy-Δ^12,14-prostaglandin J₂ inhibits the expression of microsomal prostaglandin E synthase type 2 in colon cancer cells
Schroeder O; Yudina Y; Sabirsh A; Zahn N; Haeggstrom JZ; Stein J
Article: PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS. 2005;73(6):431-440
Non-specific effects of leukotriene synthesis inhibitors on HeLa cell physiology.
Sabirsh A; Bristulf J; Karlsson U; Owman C; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(39):33477-33486
Leukotriene A₄ hydrolase, insights into the molecular evolution by homology modeling and mutational analysis of enzyme from Saccharomyces cerevisiae
Tholander F; Kull F; Ohlson E; Shafqat J; Thunnissen MMGM; Haeggström JZ
Article: JOURNAL OF LIPID RESEARCH. 2005;46(6):1339-1346
Fluorescent leukotriene B4: potential applications.
Sabirsh A; Wetterholm A; Bristulf J; Leffler H; Haeggström JZ; Owman C
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2005;62(1):87-94
Microsomal glutathione S-transferases:: selective up-regulation of leukotriene C₄ synthase during lipopolysaccharide-induced pyresis
Schröder O; Sjöström M; Qiu H; Jakobsson PJ; Haeggström JZ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2004;324(2):815-821
Novel inhibitory effect on 5-lipoxygenase activity by the anti-asthma drug montelukast.
Ramires R; Caiaffa MF; Tursi A; Haeggström JZ; Macchia L
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(28):29023-29030
The rat leukocyte-type 12-lipoxygenase exhibits an intrinsic hepoxilin A₃ synthase activity
Nigam S; Patabhiraman S; Ciccoli R; Ishdorj G; Schwarz K; Petrucev B; Kühn H; Haeggström JZ
Article: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 2004;287(1):H419-H424
Leukotriene B₄ is an indirectly acting vasoconstrictor in guinea pig aorta via an inducible type of BLT receptor
Bäck M; Qiu H; Haeggström JZ; Sakata K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(26):27376-27382
Leukotriene A4 hydrolase: identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates.
Rudberg PC; Tholander F; Andberg M; Thunnissen MMGM; Haeggström JZ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;312(2):271-276
Molecular and catalytic properties of three rat leukotriene C₄ synthase homologs
Schröder O; Sjöström M; Qiu H; Stein J; Jakobsson PJ; Haeggström JZ
Article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2003;23(8):e37-e41
Dominant expression of the CysLT₂ receptor accounts for calcium signaling by cysteinyl leukotrienes in human umbilical vein endothelial cells
Sjöström M; Johansson AS; Schröder O; Qiu H; Palmblad J; Haeggström JZ
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2003;59(Pt 6):1093-1095
Crystallization and X-ray diffraction data analysis of leukotriene A₄ hydrolase from Saccharomyces cerevisiae
Andersson B; Kull F; Haeggström JZ; Thunnissen MMGM
Article: FASEB JOURNAL. 2002;16(10):1648-1650
Crystal structures of leukotriene A₄ hydrolase in complex with captopril and two competitive tight-binding inhibitors
Thunnissen MMGM; Andersson B; Samuelsson B; Wong CH; Haeggström JZ
Article: PROSTAGLANDINS & OTHER LIPID MEDIATORS. 2002;68-69:495-510
Leukotriene A4 hydrolase.
Haeggström JZ; Kull F; Rudberg PC; Tholander F; Thunnissen MMGM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2002;1583(1):53-62
Human mast cells express two leukotriene C₄ synthase isoenzymes and the CysLT₁ receptor
Sjöström M; Jakobsson PJ; Juremalm M; Ahmed A; Nilsson G; Macchia L; Haeggström JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(7):4215-4220
Leukotriene A₄ hydrolase:: Selective abrogation of leukotriene B₄ formation by mutation of aspartic acid 375
Rudberg PC; Tholander F; Thunnissen MMGM; Samuelsson B; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(2):1398-1404
Leukotriene A4 hydrolase/aminopeptidase. Glutamate 271 is a catalytic residue with specific roles in two distinct enzyme mechanisms.
Rudberg PC; Tholander F; Thunnissen MMGM; Haeggström JZ
Article: NEUROSCIENCE. 2002;115(3):891-897
Expression of microsomal glutathione S-transferase type 3 mRNA in the rat nervous system
Fetissov SO; Schröder O; Jakobsson PJ; Samuelsson B; Haeggström JZ; Hökfelt T
Article: BIOCHEMISTRY. 2001;40(42):12695-12703
Saccharomyces cerevisiae leukotriene A₄ hydrolase:: Formation of leukotriene B₄ and identification of catalytic residues
Kull F; Ohlson E; Lind B; Haeggström JZ
Article: FEBS JOURNAL. 2001;268(9):2578-2586
Human umbilical vein endothelial cells generate leukotriene C₄ via microsomal glutathione S-transferase type 2 and express the CysLT₁ receptor
Sjöström M; Jakobsson PJ; Heimburger M; Palmblad J; Haeggström JZ
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2001;8(2):131-135
Crystal structure of human leukotriene A₄ hydrolase, a bifunctional enzyme in inflammation
Thunnissen MMGM; Nordlund P; Haeggström JZ
Article: CELL AND TISSUE RESEARCH. 2001;303(2):235-252
Cyclooxygenase-1 and cyclooxygenase-2 expression in rat kidney and adrenal gland after stimulation with systemic lipopolysaccharide -: In situ hybridization and immunocytochemical studies
Ichitani Y; Holmberg K; Maunsbach AB; Haeggström JZ; Samuelsson B; De Witt D; Hökfelt T
Article: BIOCHEMICAL JOURNAL. 2000;345 Pt 3(Pt 3):621-625
Leukotriene A4 hydrolase: a critical role of glutamic acid-296 for the binding of bestatin.
Andberg M; Wetterholm A; Medina JF; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(49):34683-34690
Cloning and characterization of a bifunctional leukotriene A(4) hydrolase from Saccharomyces cerevisiae.
Kull F; Ohlson E; Haeggström JZ
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;265(3):617-624
5-Lipoxygenase upregulation by dexamethasone in human mast cells.
Colamorea T; Di Paola R; Macchia F; Guerrese MC; Tursi A; Butterfield JH; Caiaffa MF; Haeggström JZ; Macchia L
Article: CHEMISTRY-A EUROPEAN JOURNAL. 1998;4(9):1698-1713
Probing the activities and mechanisms of leukotriene A₄ hydrolase with synthetic inhibitors
Hogg JH; Ollmann IR; Wetterholm A; Andberg MB; Haeggstrom J; Samuelsson B; Wong CH
Article: FEBS LETTERS. 1998;433(3):219-222
Purification and characterization of leukotriene A4 hydrolase from Xenopus laevis oocytes.
Strömberg-Kull F; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(19):11570-11575
Analysis of the molecular mechanism of substrate-mediated inactivation of leukotriene A4 hydrolase.
Mueller MJ; Andberg M; Haeggström JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1997;272(37):23057-23063
Mutation of tyrosine 383 in leukotriene A(4) hydrolase allows conversion of leukotriene A(4) into 5S,6S-dihydroxy-7,9-trans-11,14-cis-eicosatetraenoic acid - Implications for the epoxide hydrolase mechanism
Andberg MB; Hamberg M; Haeggstrom JZ
Article: NEUROREPORT. 1997;8(13):2949-2952
Increased levels of cyclooxygenase-2 mRNA in the rat spinal cord after peripheral inflammation: an in situ hybridization study
Ichitani Y; Shi TJ; Haeggstrom JZ; Samuelsson B; Hokfelt T
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;236(2):355-359
Effects of metal ions on the binding activity of the human leukocyte leukotriene B-4 receptor
Ng CF; Haeggstrom JZ; Samuelsson B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;233(2):496-501
Expression of prostaglandin endoperoxide H synthase 1 and 2 in human placenta at term.
Macchia L; Di Paola R; Guerrese MC; Chiechi LM; Tursi A; Caiaffa MF; Haeggstrom JZ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1996;271(40):24345-24348
Leukotriene A(4) hydrolase, mutation of tyrosine 378 allows conversion of leukotriene A(4) into an isomer of leukotriene B-4
Mueller MJ; Andberg MB; Samuelsson B; Haeggstrom JZ
Article: FASEB JOURNAL. 1996;10(10):1147-1158
Lipid mediator networks in cell signaling: update and impact of cytokines.
Serhan CN; Haeggström JZ; Leslie CC
Article: FEBS JOURNAL. 1996;238(3):599-605
Formation of a novel enzymatic metabolite of leukotriene A(4) in tissues of Xenopus laevis
Stromberg F; Hamberg M; Rosenqvist U; Dahlen SE; Haeggstrom JZ
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1996;93(12):5931-5935
Leukotriene A(4) hydrolase: Protection from mechanism-based inactivation by mutation of tyrosine-378
Mueller MJ; Blomster M; Oppermann UCT; Jornvall H; Samuelsson B; Haeggstrom JZ
Article: JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1995;275(1):31-37
POTENT AND SELECTIVE INHIBITORS OF LEUKOTRIENE A(4) HYDROLASE - EFFECTS ON PURIFIED ENZYME AND HUMAN POLYMORPHONUCLEAR LEUKOCYTES
WETTERHOLM A; HAEGGSTROM JZ; SAMUELSSON B; YUAN W; MUNOZ B; WONG CH
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 1995;3(10):1405-1415
AMINO HYDROXAMIC ACIDS AS POTENT INHIBITORS OF LEUKOTRIENE A(4) HYDROLASE
HOGG JH; OLLMANN IR; HAEGGSTROM JZ; WETTERHOLM A; SAMUELSSON B; WONG CH
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(18):8383-8387
LEUKOTRIENE A(4) HYDROLASE - MAPPING OF A HENICOSAPEPTIDE INVOLVED IN MECHANISM-BASED INACTIVATION
MUELLER MJ; WETTERHOLM A; BLOMSTER M; JORNVALL H; SAMUELSSON B; HAEGGSTROM JZ
Article: FEBS JOURNAL. 1995;231(3):528-534
Evidence for a catalytic role of tyrosine 383 in the peptidase reaction of leukotriene A4 hydrolase.
Blomster M; Wetterholm A; Mueller MJ; Haeggström JZ
Article: BIOORGANIC & MEDICINAL CHEMISTRY. 1995;3(7):969-995
INVESTIGATION OF THE INHIBITION OF LEUKOTRIENE A(4) HYDROLASE
OLLMANN IR; HOGG JH; MUNOZ B; HAEGGSTROM JZ; SAMUELSSON B; WONG CH
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1995;1257(1):58-74
ARACHIDONIC-ACID METABOLISM IN THE HUMAN MAST-CELL LINE HMC-1 - 5-LIPOXYGENASE GENE-EXPRESSION AND BIOSYNTHESIS OF THROMBOXANE
MACCHIA L; HAMBERG M; KUMLIN M; BUTTERFIELD JH; HAEGGSTROM JZ
Article: BIOCHEMISTRY. 1995;34(11):3536-3543
CHEMICAL MODIFICATION OF LEUKOTRIENE A(4) HYDROLASE - INDICATIONS FOR ESSENTIAL TYROSYL AND ARGINYL RESIDUES AT THE ACTIVE-SITE
MUELLER MJ; SAMUELSSON B; HAEGGSTROM JZ
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Review: ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY. 2023;63:407-428
Structures of Leukotriene Biosynthetic Enzymes and Development of New Therapeutics
Haeggstrom JZ; Newcomer ME
Review: BIOCHEMICAL PHARMACOLOGY. 2022;204:115208
Metabolite G-protein coupled receptor signaling: Potential regulation of eicosanoids
Tang X; Hou Y; Schwartz TW; Haeggstrom JZ
Review: JOURNAL OF MOLECULAR BIOLOGY. 2020;432(18):4999-5022
Integral Membrane Enzymes in Eicosanoid Metabolism: Structures, Mechanisms and Inhibitor Design
Thulasingam M; Haeggstrom JZ
Review: MOLECULAR ASPECTS OF MEDICINE. 2020;74:100894
The Atlas of Inflammation Resolution (AIR)
Serhan CN; Gupta SK; Perretti M; Godson C; Brennan E; Li Y; Soehnlein O; Shimizu T; Werz O; Chiurchiu V; Azzi A; Dubourdeau M; Gupta SS; Schopohl P; Hoch M; Gjorgevikj D; Khan FM; Brauer D; Tripathi A; Cesnulevicius K; Lescheid D; Schultz M; Sarndahl E; Repsilber D; Kruse R; Sala A; Haeggstrom JZ; Levy BD; Filep JG; Wolkenhauer O
Review: ANTIOXIDANTS & REDOX SIGNALING. 2018;29(3):275-296
The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders
Araujo AC; Wheelock CE; Haeggstrom JZ
Review: JOURNAL OF CLINICAL INVESTIGATION. 2018;128(7):2680-2690
Leukotriene biosynthetic enzymes as therapeutic targets
Haeggstrom JZ
Review: SEMINARS IN IMMUNOLOGY. 2017;33(C):3-15
Biosynthesis of leukotriene B₄
Wan M; Tang X; Stsiapanava A; Haeggstrom JZ
Review: EXPERT OPINION ON THERAPEUTIC TARGETS. 2014;18(1):79-93
Targeting leukotriene B₄ in inflammation
Di Gennaro A; Haeggstrom JZ
Editorial comment: CHEMISTRY AND BIOLOGY. 2013;20(2):138-140
Resolving Resolvins
Haeggstrom JZ; Hamberg M
Review: TRENDS IN MOLECULAR MEDICINE. 2012;18(4):233-243
Prostanoids in tumor angiogenesis: therapeutic intervention beyond COX-2.
Salvado MD; Alfranca A; Haeggström JZ; Redondo JM
Review: ADVANCES IN IMMUNOLOGY, VOL 150. 2012;116:51-92
The Leukotrienes: Immune-Modulating Lipid Mediators of Disease
Di Gennaro A; Haeggstrom JZ
Review: CHEMICAL REVIEWS. 2011;111(10):5866-5898
Lipoxygenase and Leukotriene Pathways: Biochemistry, Biology, and Roles in Disease
Haeggstrom JZ; Funk CD
Review: CURRENT PHARMACEUTICAL BIOTECHNOLOGY. 2011;12(7):1026-1052
Lipid Mediator Profiling in Pulmonary Disease
Lundstrom SL; Balgoma D; Wheelock AM; Haeggstrom JZ; Dahlen S-E; Wheelock CE
Review: BIOCHIMIE. 2010;92(6):676-681
Structures and mechanisms of enzymes in the leukotriene cascade
Rinaldo-Matthis A; Haeggstrom JZ
Review: MOLECULAR BIOSYSTEMS. 2010;6(2):289-304
The use of network analyses for elucidating mechanisms in cardiovascular disease
Diez D; Wheelock AM; Goto S; Haeggstrom JZ; Paulsson-Berne G; Hansson GK; Hedin U; Gabrielsen A; Wheelock CE
Review: MOLECULAR BIOSYSTEMS. 2009;5(6):588-602
Systems biology approaches and pathway tools for investigating cardiovascular disease
Wheelock CE; Wheelock AM; Kawashima S; Diez D; Kanehisa M; van Erk M; Kleemann R; Haeggstrom JZ; Goto S
Review: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(49):50639-50642
Leukotriene A4 hydrolase/aminopeptidase, the gatekeeper of chemotactic leukotriene B4 biosynthesis.
Haeggström JZ
Meeting abstract: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2004;43(5):283A
Profiling inflammation in the ischemic human heart in vivo
Gabrielsen A; Lawler P; Haeggström J; Paulsson GB; Wang YZ; Steinbruchel D; Kastrup J; Hansson G
Review: THE SCIENTIFIC WORLD JOURNAL. 2002;2:1734-1749
Functional properties and molecular architecture of leukotriene A4 hydrolase, a pivotal catalyst of chemotactic leukotriene formation.
Haeggström JZ; Nordlund P; Thunnissen MMGM
Review: CELLULAR AND MOLECULAR LIFE SCIENCES. 2002;59(5):742-753
Enzymes and receptors in the leukotriene cascade.
Haeggström JZ; Wetterholm A
Published conference paper: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2000;161(2 Pt 2):S25-S31
Structure, function, and regulation of leukotriene A4 hydrolase.
Haeggström JZ
Review: ERNST SCHERING RESEARCH FOUNDATION WORKSHOP. 2000;(31):85-96
Leukotriene-A4 hydrolase: probing the active sites and catalytic mechanisms by site-directed mutagenesis.
Haeggström JZ; Wetterholm A
Published conference paper: HYPERTENSION. 2000;35(1):373-378
Cyclooxygenase-2 involved in stimulation of renal mechanosensitive neurons
Kopp UC; Cicha MZ; Smith LA; Haeggström JZ; Samuelsson B; Hökfelt T
Review: CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY. 1999;17(1-2):111-131
Leukotriene A4 hydrolase and the committed step in leukotriene B4 biosynthesis.
Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1999;469:319-325
Evidence for a carbocation intermediate in the enzymatic transformation of leukotriene A₄ into leukotriene B₄
Andberg M; Hamberg M; Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:375-378
Leukotriene A₄ hydrolase activity in Xenopus laevis
Strömberg F; Rosenqvist U; Dahlén SE; Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;433:149-152
Mutation of Tyr-383 in leukotriene A4 hydrolase: effects on enzyme activities.
Andberg M; Wetterholm A; Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;400A:153-157
Leukotriene A4 hydrolase: differential inhibition of the catalytic activities by divalent cations.
Wetterholm A; Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;407:555-559
Enzymatic conversion of leukotriene A4 into 5(S),12(R)-diHETE in frog tissues.
Strömberg F; Haeggström JZ
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 1997;407:1-7
Studies on the active site of leukotriene A(4) hydrolase
Wetterholm A; Mueller MJ; Blomster M; Samuelsson B; Haeggstrom JZ
Published conference paper: ADVANCES IN PROSTAGLANDIN, THROMBOXANE, AND LEUKOTRIENE RESEARCH. 1995;23:179-181
Metal inhibition of LTA4 hydrolase and cellular 5-lipoxygenase activity.
Wetterholm A; Macchia L; Haeggström JZ
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Professor, Senior, Medicinsk biokemi och biofysik, Karolinska Institutet, 2024-2025
Professor, Medicinsk biokemi och biofysik, Karolinska Institutet, 2000-2024

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