Iva Gunnarsson
Adjungerad Professor | Docent
E-postadress: iva.gunnarsson@ki.se
Besöksadress: ,
Postadress: K2 Medicin, Solna, K2 Reuma Antovic A, 171 77 Stockholm
Om mig
- *Research focus*: We perform translational studies on two autoimmune
diseases, systemic lupus erythematos (SLE) and ANCA-associated vasculitis
(AAV) with a special focus on renal involvement. We have identified promising
biomarkers that reflect renal activity and damage development,
histopathological studies in effects of therapy, and participated in
genetical studies. We have collected large cohorts with biomaterial from the
time-point of renal biopsies, both before and after immunosuppressive
treatment.
I am the leader of studies regarding the use of biologics (rituximab,
belimumab) in SLE and in principal investigator for a large cohort of AAV,
performed in collaboration with nephrology at Karolinska. I also have a
research interest in SLE pregnancy and males with SLE.
*Introduction/history*: I am a senior consultant in Rheumatology and work
half-time in the clinic, mainly with inflammatory systemic diseases and
half-time with research as adjunct professor in rheumatology. I defended my
thesis in 1999.
*Major lines of research:* Systemic lupus erythematosus and ANCA-associated
vasculitis, renal involvement, use of biologics, biomarkers
*Team members: *
Agneta Zickert, rheumatologist, postdoc on studies on lupus nephritis
Francesca Faustini, rheumatologist, PhD in SLE research
Anna Juto, PhD student in vasculitis research
Jakob Gerhardsson, PhD student in SLE research
Charikleia Chrysostomou, nephrologist, pre-PhD student in SLE research
Peter Hemmingsson, nephrologist, pre-PhD student in vasculitis research
Linnea Karlsson, pre-PhD student in renal SLE research
*Selected publications:*
1) Resorption of immune deposits in membranous lupus nephritis following
rituximab versus conventional immunosuppressive treatment Agneta
Zickert , Klas Lannfelt , Jan Schmidt Mende, Birgitta Sundelin, and *Iva
Gunnarsson*. Rheumatology 2020
1) Myriam Martin, Rebecca Trattner Evetovics, Sara C. Nilsson, Albin Björk,
Agneta Zickert, Anna M. Blom and *Iva Gunnarsson* Plasma C4d correlates
with C4d deposition in kidneys and with treatment response in systemic
lupus erythematosus with renal involvement. Frontiers Immunology 2020
1) Antovic A, Mobarrez F, Manojlovic M, Soutari N, De Porta Baggemar
V, Nordin A, Bruchfeld A, Vojinovic J, * Gunnarsson I.
*Microparticles Expressing Myeloperoxidase and Complement C3a and C5a as
Markers of Renal Involvement in Antineutrophil Cytoplasmic
Antibody-associated Vasculitis. The Journal of rheumatology 2020 47 - 5
714-721
1) Arnaud L, Nordin A, Lundholm H, Svenungsson E, Hellbacher E, Wikner
J, Zickert A, * Gunnarsson I. *Effect of Corticosteroids and
Cyclophosphamide on Sex Hormone Profiles in Male Patients With Systemic
Lupus Erythematosus or Systemic Sclerosis. Arthritis & - rheumatology
(Hoboken, N.J.) 2017 69 - 6 1272-1279
1) Gerhardsson J, Sundelin B, Zickert A, Padyukov L, Svenungsson E,
* Gunnarsson I. *Histological antiphospholipid-associated nephropathy
versus lupus nephritis in patients with systemic lupus erythematosus: an
observational cross-sectional study with longitudinal follow-up.
Arthritis research & - therapy 2015 17
- 109-
Artiklar
- Article: ARTHRITIS & RHEUMATOLOGY. 2024
- Article: QJM-AN INTERNATIONAL JOURNAL OF MEDICINE. 2024;117(8):581-588
- Article: RHEUMATOLOGY. 2024;:keae332
- Article: RMD OPEN. 2024;10(2):e004039
- Article: RHEUMATOLOGY. 2024;:keae134
- Article: ARTHRITIS RESEARCH & THERAPY. 2024;26(1):65
- Article: JOURNAL OF AUTOIMMUNITY. 2024;143:103166
- Article: CLINICAL RHEUMATOLOGY. 2023;42(11):2981-2986
- Article: CLINICAL RHEUMATOLOGY. 2023;42(10):2889-2895
- Article: CLINICAL IMMUNOLOGY. 2023;255:109763
- Article: RHEUMATOLOGY. 2023;62(9):3213-3218
- Article: RHEUMATOLOGY. 2023;62(8):2850-2854
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2023;52(4):418-423
- Article: ARTHRITIS RESEARCH & THERAPY. 2023;25(1):107
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2023;52(3):293-301
- Article: KIDNEY INTERNATIONAL. 2023;103(5):973-985
- Article: RHEUMATOLOGY. 2023;62(2):924-933
- Article: LUPUS. 2023;32(2):252-262
- Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(11):1842-1850
- Article: LUPUS SCIENCE & MEDICINE. 2022;9(1):e000752
- Article: LUPUS SCIENCE & MEDICINE. 2022;9(1):e000744
- Article: RHEUMATOLOGY. 2022;61(8):3461-3470
- Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(8):1440-1450
- Article: RHEUMATOLOGY ADVANCES IN PRACTICE. 2022;6(2):rkac062
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2022;207(2):199-204
- Article: LUPUS SCIENCE & MEDICINE. 2022;9(1):e000607
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2022;132(1):e147334
- Article: ACR OPEN RHEUMATOLOGY. 2022;4(1):27-39
- Article: FRONTIERS IN IMMUNOLOGY. 2022;13:826152
- Article: THROMBOSIS AND HAEMOSTASIS. 2021;121(10):1299-1309
- Article: LUPUS SCIENCE & MEDICINE. 2021;8(1):e000510
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(9):1183-1189
- Article: RHEUMATOLOGY. 2021;60(9):4348-4354
- Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):211
- Article: LUPUS SCIENCE & MEDICINE. 2021;8(1):e000515
- Article: RHEUMATOLOGY. 2021;60(7):3443-3450
- Article: GENES AND IMMUNITY. 2021;22(3):194-202
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2021;205(1):44-52
- Article: LUPUS. 2021;30(7):1031-1038
- Article: LUPUS SCIENCE & MEDICINE. 2021;8(1):e000471
- Article: RHEUMATOLOGY. 2021;60(3):1445-1455
- Article: TRANSLATIONAL RESEARCH. 2021;229:69-82
- Article: ARCHIVES OF RHEUMATOLOGY. 2021;36(1):89-100
- Article: LUPUS SCIENCE & MEDICINE. 2021;8(1):e000463
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:756941
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(1):109-117
- Article: FRONTIERS IN IMMUNOLOGY. 2021;12:666114
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2021;29(1):184-193
- Article: SCIENTIFIC REPORTS. 2020;10(1):21126
- Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2020;50(6):1387-1393
- Article: RHEUMATOLOGY. 2020;59(11):3264-3274
- Article: JOURNAL OF MOLECULAR MEDICINE-JMM. 2020;98(9):1279-1286
- Article: RHEUMATOLOGY. 2020;59(9):2237-2249
- Article: RHEUMATOLOGY ADVANCES IN PRACTICE. 2020;4(2):rkaa056
- Article: JOURNAL OF RHEUMATOLOGY. 2020;47(6):865-875
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(10):E3463-3463
- Article: JOURNAL OF RHEUMATOLOGY. 2020;47(5):714-721
- Article: RHEUMATOLOGY. 2020;59(5):968-978
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(3):363-369
- Article: CLINICAL IMMUNOLOGY. 2020;212:108349
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(2):254-261
- Article: KIDNEY INTERNATIONAL REPORTS. 2020;5(2):182-188
- Article: FRONTIERS IN PHARMACOLOGY. 2020;11:613
- Article: FRONTIERS IN IMMUNOLOGY. 2020;11:582737
- Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):60
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):259
- Article: NATURE COMMUNICATIONS. 2019;10(1):5120
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(10):1363-1370
- Article: JOURNAL OF AUTOIMMUNITY. 2019;102:142-149
- Article: ARTHRITIS CARE & RESEARCH. 2019;71(6):811-821
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):107
- Article: JOURNAL OF PROTEOME RESEARCH. 2019;18(3):1208-1217
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27(3):432-441
- Article: KIDNEY INTERNATIONAL. 2019;95(3):655-665
- Article: ARTHRITIS RESEARCH & THERAPY. 2019;21(1):62
- Article: HUMAN GENETICS. 2019;138(2):141-150
- Article: EBIOMEDICINE. 2019;40:517-527
- Article: EXPERT OPINION ON BIOLOGICAL THERAPY. 2019;19(2):157-168
- Article: PLOS ONE. 2019;14(2):e0212068
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:7
- Article: FRONTIERS IN IMMUNOLOGY. 2019;10:1029
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;194(1):27-38
- Article: EXPERT OPINION ON BIOLOGICAL THERAPY. 2018;18(8):911-920
- Article: LUPUS. 2018;27(9):1470-1478
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(7):1063-1069
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(5):736-743
- Article: ATHEROSCLEROSIS. 2018;270:1-7
- Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):36
- Article: LUPUS SCIENCE & MEDICINE. 2018;5(1):e000260
- Article: LUPUS SCIENCE & MEDICINE. 2018;5(1):e000254
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2017;46(6):474-483
- Article: CLINICAL IMMUNOLOGY. 2017;183:304-315
- Article: JOURNAL OF THROMBOSIS AND HAEMOSTASIS. 2017;15(9):1799-1806
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(9):1607-1613
- Article: SCIENTIFIC REPORTS. 2017;7(1):6236
- Article: NATURE COMMUNICATIONS. 2017;8:16021
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2017;46(4):263-272
- Article: ARTHRITIS RESEARCH & THERAPY. 2017;19(1):139
- Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(6):1272-1279
- Article: RHEUMATOLOGY. 2017;56(5):818-828
- Article: METABOLOMICS. 2017;13(10):114
- Article: SCIENTIFIC REPORTS. 2016;6:36025
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2016;45(5):404-407
- Article: CLINICAL KIDNEY JOURNAL. 2016;9(4):552-555
- Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(8):1970-1980
- Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2016;45(6):684-690
- Article: LUPUS SCIENCE & MEDICINE. 2016;3(1):e000170
- Article: PLOS ONE. 2016;11(6):e0158076
- Article: ARTHRITIS RESEARCH & THERAPY. 2015;17:338
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2015;181(3):417-426
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2015;74(8):1537-1543
- Article: LUPUS. 2015;24(9):955-965
- Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):109
- Article: BMC IMMUNOLOGY. 2015;16(1):7
- Article: LUPUS SCIENCE & MEDICINE. 2015;2(1):e000061
- Article: LUPUS SCIENCE & MEDICINE. 2014;1(1):e000018
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2013;21(9):994-999
- Article: HUMAN IMMUNOLOGY. 2013;74(8):957-960
- Article: CIRCULATION-GENOMIC AND PRECISION MEDICINE. 2013;6(3):255-263
- Article: GENES AND IMMUNITY. 2013;14(4):217-222
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(6):1018-1025
- Article: MOLECULAR MEDICINE. 2013;19(1):109-114
- Article: RHEUMATOLOGY. 2013;52(5):847-855
- Article: LUPUS. 2013;22(5):477-485
- Article: LUPUS. 2013;22(4):381-389
- Article: LUPUS. 2013;22(4):372-380
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(3):200-212
- Article: RHEUMATOLOGY. 2013;52(3):501-509
- Article: PLOS ONE. 2013;8(12):e84450
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2012;41(5):383-390
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2012;41(4):290-297
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2012;367(3):214-223
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2012;27(5):1916-1923
- Article: CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2012;7(5):727-734
- Article: LUPUS. 2012;21(6):586-595
- Article: SCANDINAVIAN JOURNAL OF UROLOGY AND NEPHROLOGY. 2012;46(2):148-155
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2012;41(2):116-119
- Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(1):R36
- Article: ARTHRITIS RESEARCH & THERAPY. 2012;14(2):R46
- Article: ARTHRITIS & RHEUMATOLOGY. 2011;63(12):3942-3951
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2011;19(4):479-484
- Article: MOLECULAR MEDICINE. 2011;17(1-2):29-35
- Article: ARTHRITIS RESEARCH & THERAPY. 2011;13(6):r206
- Article: KIDNEY INTERNATIONAL. 2010;78(12):1281-1287
- Article: RHEUMATOLOGY. 2010;49(10):1935-1942
- Article: LUPUS. 2010;19(10):1187-1194
- Article: HUMAN MOLECULAR GENETICS. 2010;19(16):3282-3294
- Article: RHEUMATOLOGY. 2010;49(8):1502-1504
- Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(6):1702-1711
- Article: PLOS ONE. 2010;5(5):e10559
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2010;69(5):834-840
- Article: CLINICAL NEPHROLOGY. 2010;73(3):221-228
- Article: NATURE GENETICS. 2009;41(11):1228-1233
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2009;24(10):3061-3067
- Article: IMMUNOLOGY. 2009;126(1):140-146
- Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(6):R188
- Article: ARTHRITIS RESEARCH & THERAPY. 2009;11(6):R186
- Article: HUMAN MOLECULAR GENETICS. 2008;17(18):2868-2876
- Article: HUMAN MOLECULAR GENETICS. 2008;17(6):872-881
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(3):330-334
- Article: NEW ENGLAND JOURNAL OF MEDICINE. 2008;358(9):900-909
- Article: NATURE GENETICS. 2008;40(2):211-216
- Article: HLA. 2007;70(5):412-414
- Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(9):3080-3086
- Article: RHEUMATOLOGY. 2007;46(9):1417-1421
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(16):6758-6763
- Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(4):1263-1272
- Article: GENES AND IMMUNITY. 2007;8(1):69-74
- Article: CLINICAL IMMUNOLOGY. 2007;122(1):62-74
- Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2006;63(6):444-452
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2006;65(6):791-795
- Article: ARTHRITIS RESEARCH & THERAPY. 2006;8(6):R167
- Article: GENES AND IMMUNITY. 2005;6(8):658-662
- Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(1):192-200
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2004;33(6):423-427
- Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(1):327-328
- Article: NATURE GENETICS. 2002;32(4):666-669
- Article: JOURNAL OF RHEUMATOLOGY. 2002;29(4):693-699
- Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(3):561-566
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2001;30(5):282-289
- Article: GENOMICS. 2000;70(3):307-314
- Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2000;18(5):565-570
- Article: RHEUMATOLOGY. 2000;39(8):886-893
- Article: GENES AND IMMUNITY. 2000;1(6):380-385
- Article: ANNALS OF THE RHEUMATIC DISEASES. 1999;58(10):623-629
- Article: LUPUS. 1999;8(2):142-150
- Article: JOURNAL OF AUTOIMMUNITY. 1998;11(1):29-38
- Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 1997;12(11):2263-2268
- Article: BRITISH JOURNAL OF RHEUMATOLOGY. 1997;36(10):1089-1094
- Article: JOURNAL OF AUTOIMMUNITY. 1997;10(4):415-423
- Article: BRITISH JOURNAL OF RHEUMATOLOGY. 1997;36(1):32-37
- Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 1997;26(1):65-66
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Alla övriga publikationer
- Letter: RHEUMATOLOGY. 2024;:keae353
- Editorial comment: LANCET RHEUMATOLOGY. 2023;5(9):e501-e506
- Review: RHEUMATOLOGY ADVANCES IN PRACTICE. 2023;7(3):rkad092
- Review: CLINICAL RHEUMATOLOGY. 2021;40(5):1687-1695
- Letter: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(3):404-406
- Review: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2020;92(5):e12958
- Letter: RHEUMATOLOGY. 2020;59(6):1454-1455
- Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2017;139(5):1684-1687.e10
- Review: AUTOIMMUNITY REVIEWS. 2017;16(4):343-351
- Review: ANNALS OF MEDICINE. 2012;44(3):225-232
- Letter: AMERICAN JOURNAL OF KIDNEY DISEASES. 2012;59(4):585-586
- Letter: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(6):1172-1173
- Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:a60-A61
- Meeting abstract: MOLECULAR IMMUNOLOGY. 2010;47(13):2285
- Meeting abstract: CLINICAL IMMUNOLOGY. 2010;135:S114
- Letter: ARTHRITIS & RHEUMATOLOGY. 2008;58(2):634
- Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S151
- Letter: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2006;21(6):1742-1743
- Letter: ARTHRITIS & RHEUMATOLOGY. 2005;52(12):4050-4051
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2005;6(1):65-66
- Editorial comment: ARTHRITIS & RHEUMATOLOGY. 2004;50(4):1348-1350
- Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):317
- Letter: ANNALS OF THE RHEUMATIC DISEASES. 2001;60(7):727
- Thesis / dissertation: 1999
- Letter: LUPUS. 1999;8(6):486-488
- Published conference paper: JOURNAL OF AUTOIMMUNITY. 1998;11(5):503-508
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Anställningar
- Adjungerad Professor, Medicin, Solna, Karolinska Institutet, 2019-2026
Examina och utbildning
- Docent, Reumatologi, Karolinska Institutet, 2011
- MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 1999
Handledare
- Sara Brolin, Educational needs, quality of life, and health care support in persons with systemic rheumatic disease, 2023
- Annika Granath, Patients perspective in vasculitis, 2021