Hugo Zeberg

Hugo Zeberg

Biträdande Lektor
E-postadress: hugo.zeberg@ki.se
Telefon: +46852482909
Besöksadress: Solnavägen 9, Biomedicum C4, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa FK Genetisk och farmakologisk epidemiologi, 171 77 Stockholm

Forskningsbeskrivning

  • We study gene flow from Neandertals and Denisovans into modern humans. In
    addition, we are interested in genetic variability and the functional
    consequences thereof, particularly for membrane-bound proteins such as
    receptors and ion channels. Other topics of interest include the genetic
    predisposition to infectious diseases, such as COVID-19 (see
    https://swecovid.org/ [1]).
    The Zeberg laboratory is pleased to consider applications from prospective
    master- and PhD students, particularly keen experimentalists.
    Group members: Richard Ågren, Kristoffer Sahlholm, Hugh Robinson
    *Selection of recent publications*
    Genetic determinants of mannose-binding lectin activity predispose to
    thromboembolic complications in critical COVID-19. [2] Hultström M,
    Frithiof R, Grip J, /.../, Lipcsey M, *Zeberg H* * & Eriksson O* /Nature
    Immunology 2022 May/
    The major genetic risk factor for severe COVID-19 is associated with
    protection against HIV. [3] *Zeberg H */PNAS 2022 Feb/
    Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe
    COVID-19. [4] Huffman JE, Butler-Laporte G, Khan A, /.../, Kiryluk K,
    Richards JB & *Zeberg H* /Nature Genetics 2022 Jan/
    A substitution in the glutathione reductase lowers electron leakage and
    inflammation in modern humans. [5] Coppo C, Mishra P, Siefert N ,
    Holmgren A, Pääbo S & *Zeberg H* /Science Advances 2022 Jan/
    Age-dependent impact of the major common genetic risk factor for COVID-19 on
    severity and mortality. [6]
    Nakanishi T, Pigazzini S, Degenhardt F, /.../, *Zeberg H*, Richards JB &
    Ganna A/ J Clin Invest 2021 Oct/
    Mapping the human genetic architecture of COVID-19. [7]
    COVID-19 Host Genetics Initiative (incl. SweCovid). /Nature 2021 Jul/
    A Neanderthal OAS1 isoform protects individuals of European ancestry against
    COVID-19 susceptibility and severity. [8]
    Zhou S, Butler-Laporte G, Nakanishi T, /.../, *Zeberg H*, Langenberg C,
    Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE & Richards JB /Nature
    Medicine 2021 Feb/
    A genomic region associated with protection against severe COVID-19 is
    inherited from Neandertals. [9]
    *Zeberg H *& Pääbo S /PNAS 2021/
    Longitudinal variability in mortality predicts COVID-19 deaths. [10]
    Lundberg JO & *Zeberg H*
    /Eur J Epidemiol 2021 Jul/
    The major genetic risk factor for severe COVID-19 is inherited from
    Neanderthals. [11]
    *Zeberg H *& Pääbo S
    /Nature 2020/
    A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day
    Humans. [12]
    *Zeberg H*, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, /et al/
    /Curr. Biol. 2020/
    The Neandertal Progesterone Receptor. [13]
    *Zeberg H*, Kelso J & Pääbo S
    /Mol. Biol. Evol. 2020/
    Antipsychotics with similar association kinetics at dopamine D2 receptors
    differ in extrapyramidal side-effects. [14]
    *Zeberg H *& Sahlholm K
    /Nature Commun 2018/
    [1] https://swecovid.org/
    [2] https://doi.org/10.1038/s41590-022-01227-w
    [3] https://pubmed.ncbi.nlm.nih.gov/35193979/
    [4] https://www.nature.com/articles/s41588-021-00996-8
    [5] https://pubmed.ncbi.nlm.nih.gov/34985944
    [6] https://pubmed.ncbi.nlm.nih.gov/34597274
    [7] https://pubmed.ncbi.nlm.nih.gov/34237774
    [8] https://pubmed.ncbi.nlm.nih.gov/33633408
    [9] https://pubmed.ncbi.nlm.nih.gov/33593941
    [10] https://pubmed.ncbi.nlm.nih.gov/34218343
    [11] https://pubmed.ncbi.nlm.nih.gov/32998156
    [12] https://pubmed.ncbi.nlm.nih.gov/32707058
    [13] https://pubmed.ncbi.nlm.nih.gov/32437543
    [14] https://pubmed.ncbi.nlm.nih.gov/30177830

Artiklar

Alla övriga publikationer

Anställningar

  • Biträdande Lektor, Fysiologi och farmakologi, Karolinska Institutet, 2023-2024

Examina och utbildning

  • Medicine Doktorsexamen, Institutionen för neurovetenskap, Karolinska Institutet, 2016
  • Läkarexamen, Karolinska Institutet, 2013

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