Hugo Zeberg

Hugo Zeberg

Biträdande Lektor
Telefon: +46852482909
Besöksadress: Solnavägen 9, Biomedicum C4, 17165 Solna
Postadress: C3 Fysiologi och farmakologi, C3 FyFa FK Genetisk och farmakologisk epidemiologi, 171 77 Stockholm


  • We study gene flow from Neandertals and Denisovans into modern humans. In
    addition, we are interested in genetic variability and the functional
    consequences thereof, particularly for membrane-bound proteins such as
    receptors and ion channels. Other topics of interest include the genetic
    predisposition to infectious diseases, such as COVID-19 (see [1]).
    The Zeberg laboratory is pleased to consider applications from prospective
    master- and PhD students, particularly keen experimentalists.
    Group members: Richard Ågren, Kristoffer Sahlholm, Hugh Robinson
    *Selection of recent publications*
    Genetic determinants of mannose-binding lectin activity predispose to
    thromboembolic complications in critical COVID-19. [2] Hultström M,
    Frithiof R, Grip J, /.../, Lipcsey M, *Zeberg H* * &
  • Eriksson O* /Nature
    Immunology 2022 May/
    The major genetic risk factor for severe COVID-19 is associated with
    protection against HIV. [3] *Zeberg H */PNAS 2022 Feb/
    Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe
    COVID-19. [4] Huffman JE, Butler-Laporte G, Khan A, /.../, Kiryluk K,
    Richards JB &
  • *Zeberg H* /Nature Genetics 2022 Jan/
    A substitution in the glutathione reductase lowers electron leakage and
    inflammation in modern humans. [5] Coppo C, Mishra P, Siefert N ,
    Holmgren A, Pääbo S &
  • *Zeberg H* /Science Advances 2022 Jan/
    Age-dependent impact of the major common genetic risk factor for COVID-19 on
    severity and mortality. [6]
    Nakanishi T, Pigazzini S, Degenhardt F, /.../, *Zeberg H*, Richards JB &

  • Ganna A/ J Clin Invest 2021 Oct/
    Mapping the human genetic architecture of COVID-19. [7]
    COVID-19 Host Genetics Initiative (incl. SweCovid). /Nature 2021 Jul/
    A Neanderthal OAS1 isoform protects individuals of European ancestry against
    COVID-19 susceptibility and severity. [8]
    Zhou S, Butler-Laporte G, Nakanishi T, /.../, *Zeberg H*, Langenberg C,
    Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE &
  • Richards JB /Nature
    Medicine 2021 Feb/
    A genomic region associated with protection against severe COVID-19 is
    inherited from Neandertals. [9]
    *Zeberg H *&
  • Pääbo S /PNAS 2021/
    Longitudinal variability in mortality predicts COVID-19 deaths. [10]
    Lundberg JO &
  • *Zeberg H*
    /Eur J Epidemiol 2021 Jul/
    The major genetic risk factor for severe COVID-19 is inherited from
    Neanderthals. [11]
    *Zeberg H *&
  • Pääbo S
    /Nature 2020/
    A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day
    Humans. [12]
    *Zeberg H*, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, /et al/
    /Curr. Biol. 2020/
    The Neandertal Progesterone Receptor. [13]
    *Zeberg H*, Kelso J &
  • Pääbo S
    /Mol. Biol. Evol. 2020/
    Antipsychotics with similar association kinetics at dopamine D2 receptors
    differ in extrapyramidal side-effects. [14]
    *Zeberg H *&
  • Sahlholm K
    /Nature Commun 2018/


Alla övriga publikationer


  • Biträdande Lektor, Fysiologi och farmakologi, Karolinska Institutet, 2023-2024

Examina och utbildning

  • Medicine Doktorsexamen, Institutionen för neurovetenskap, Karolinska Institutet, 2016
  • Läkarexamen, Karolinska Institutet, 2013

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