Hugo Zeberg

Hugo Zeberg

Assistant Professor
Telephone: +46852482909
Visiting address: Solnavägen 9, Biomedicum C4, 17165 Solna
Postal address: C3 Fysiologi och farmakologi, C3 FyFa FK Genetisk och farmakologisk epidemiologi, 171 77 Stockholm
Part of:

Research

  • We study gene flow from Neandertals and Denisovans into modern humans. In addition, we are interested in genetic variability and the functional consequences thereof, particularly for membrane-bound proteins such as receptors and ion channels. Other topics of interest include the genetic predisposition to infectious diseases, such as COVID-19 (see https://swecovid.org/ [1]). The Zeberg laboratory is pleased to consider applications from prospective master- and PhD students, particularly keen experimentalists. Group members: Richard Ågren, Kristoffer Sahlholm, Hugh Robinson *Selection of recent publications* Genetic determinants of mannose-binding lectin activity predispose to thromboembolic complications in critical COVID-19. [2] Hultström M, Frithiof R, Grip J, /.../, Lipcsey M, *Zeberg H* * & Eriksson O* /Nature Immunology 2022 May/ The major genetic risk factor for severe COVID-19 is associated with protection against HIV. [3] *Zeberg H */PNAS 2022 Feb/ Multi-ancestry fine mapping implicates OAS1 splicing in risk of severe COVID-19. [4] Huffman JE, Butler-Laporte G, Khan A, /.../, Kiryluk K, Richards JB & *Zeberg H* /Nature Genetics 2022 Jan/ A substitution in the glutathione reductase lowers electron leakage and inflammation in modern humans. [5] Coppo C, Mishra P, Siefert N , Holmgren A, Pääbo S & *Zeberg H* /Science Advances 2022 Jan/ Age-dependent impact of the major common genetic risk factor for COVID-19 on severity and mortality. [6] Nakanishi T, Pigazzini S, Degenhardt F, /.../, *Zeberg H*, Richards JB & Ganna A/ J Clin Invest 2021 Oct/ Mapping the human genetic architecture of COVID-19. [7] COVID-19 Host Genetics Initiative (incl. SweCovid). /Nature 2021 Jul/ A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity. [8] Zhou S, Butler-Laporte G, Nakanishi T, /.../, *Zeberg H*, Langenberg C, Thysell E, Pollak M, Mooser V, Forgetta V, Kaufmann DE & Richards JB /Nature Medicine 2021 Feb/ A genomic region associated with protection against severe COVID-19 is inherited from Neandertals. [9] *Zeberg H *& Pääbo S /PNAS 2021/ Longitudinal variability in mortality predicts COVID-19 deaths. [10] Lundberg JO & *Zeberg H* /Eur J Epidemiol 2021 Jul/ The major genetic risk factor for severe COVID-19 is inherited from Neanderthals. [11] *Zeberg H *& Pääbo S /Nature 2020/ A Neanderthal Sodium Channel Increases Pain Sensitivity in Present-Day Humans. [12] *Zeberg H*, Dannemann M, Sahlholm K, Tsuo K, Maricic T, Wiebe V, /et al/ /Curr. Biol. 2020/ The Neandertal Progesterone Receptor. [13] *Zeberg H*, Kelso J & Pääbo S /Mol. Biol. Evol. 2020/ Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects. [14] *Zeberg H *& Sahlholm K /Nature Commun 2018/ [1] https://swecovid.org/ [2] https://doi.org/10.1038/s41590-022-01227-w [3] https://pubmed.ncbi.nlm.nih.gov/35193979/ [4] https://www.nature.com/articles/s41588-021-00996-8 [5] https://pubmed.ncbi.nlm.nih.gov/34985944 [6] https://pubmed.ncbi.nlm.nih.gov/34597274 [7] https://pubmed.ncbi.nlm.nih.gov/34237774 [8] https://pubmed.ncbi.nlm.nih.gov/33633408 [9] https://pubmed.ncbi.nlm.nih.gov/33593941 [10] https://pubmed.ncbi.nlm.nih.gov/34218343 [11] https://pubmed.ncbi.nlm.nih.gov/32998156 [12] https://pubmed.ncbi.nlm.nih.gov/32707058 [13] https://pubmed.ncbi.nlm.nih.gov/32437543 [14] https://pubmed.ncbi.nlm.nih.gov/30177830

Articles

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Employments

  • Assistant Professor, Department of Physiology and Pharmacology, Karolinska Institutet, 2023-2024

Degrees and Education

  • Degree Of Doctor Of Philosophy, Department of neuroscience, Karolinska Institutet, 2016
  • University Medical Degree, Karolinska Institutet, 2013

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