Hong Qian

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Senior Forskare, docent. Has been long interested in hematopoietic microenvironment in normal and malignant hematopoiesis
Senior Investigator Award from Cancerfonden (the Swedish Cancer Society)

Forskningsbeskrivning

Syftet med vår forskning är att identifiera de viktigaste molekylära vägarna som påverkar sjukdomsutvecklingen samt behandlingsresultatet vid leukemi. Vi hoppas hitta nya terapeutiska mål och prognostiska markörer inom nischen för leukemi, för att förbättra effektiviteten av nuvarande behandling av sjukdomen.

Undervisning

Teaching master students, doctoral students and BMA at Karolinska Institutet

Artiklar

Article: NATURE COMMUNICATIONS. 2024;15(1):7966
Aging is associated with functional and molecular changes in distinct hematopoietic stem cell subsets
Su T-Y; Hauenstein J; Somuncular E; Dumral O; Leonard E; Gustafsson C; Tzortzis E; Forlani A; Johansson A-S; Qian H; Mansson R; Luc S
Article: SCIENTIFIC REPORTS. 2023;13(1):21787
The functional and molecular impact of triamcinolone acetonide on primary human bone marrow mesenchymal stem cells
Kumlin M; Ungerstedt J; Cai H; Leonard E; Fellaender-Tsai L; Qian H
Journal article: BLOOD. 2023;142:1786
Role of Lama4 Expression in Bone Marrow Niche for the Progression and Treatment Response of Chronic Myeloid Leukemia
Mansson A; Cai H; Gimenez JPM; Stenke L; Qian H
Journal article: BLOOD. 2023;142:2707
Protective Function of Human Skin Mesenchymal Niches for Acute Myeloid Leukemia-Initiating Stem Cells
Leonard E; Sandhow L; Cai H; Qian H
Article: JOURNAL OF CLINICAL INVESTIGATION. 2023;133(20):e169671
Antioxidants stimulate BACH1-dependent tumor angiogenesis
Wang T; Dong Y; Huang Z; Zhang G; Zhao Y; Yao H; Hu J; Tueksammel E; Cai H; Liang N; Xu X; Yang X; Schmidt S; Qiao X; Schlisio S; Stromblad S; Qian H; Jiang C; Treuter E; Bergo MO
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2023;220(10):e20220953
Skin mesenchymal niches maintain and protect AML-initiating stem cells
Sandhow L; Cai H; Leonard E; Xiao P; Tomaipitinca L; Mansson A; Kondo M; Sun X; Johansson A-S; Tryggvason K; Kasper M; Jaras M; Qian H
Article: CELL REPORTS. 2023;42(8):112961
A MYC-controlled redox switch protects B lymphoma cells from EGR1-dependent apoptosis
Yao H; Chen X; Wang T; Kashif M; Qiao X; Tuksammel E; Larsson L-G; Okret S; Sayin VI; Qian H; Bergo MO
Article: BLOOD. 2023;142(1):73-89
Characterization of the bone marrow niche in patients with chronic myeloid leukemia identifies CXCL14 as a new therapeutic option
Dolinska M; Cai H; Mansson A; Shen J; Xiao P; Bouderlique T; Li X; Leonard E; Chang M; Gao Y; Medina JP; Kondo M; Sandhow L; Johansson A-SF; Deneberg S; Soederlund S; Jaedersten M; Ungerstedt J; Tobiasson M; Ostman A; Mustjoki S; Stenke L; Le Blanc K; Hellstroem-Lindberg E; Lehmann S; Ekblom M; Olsson-Stroemberg U; Sigvarosson M; Qian H
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;152(1):205-213
Proteomic and transcriptomic screening demonstrates increased mast cell-derived CCL23 in systemic mastocytosis
Soderlund S; Boey D; van Midden W; Kjellander M; Ax K; Qian H; Dahlin JS; Ungerstedt J
Article: CANCER COMMUNICATIONS. 2023;43(6):637-660
Perivascular localized cells commit erythropoiesis in PDGF-B-expressing solid tumors
Hosaka K; Wang C; Zhang S; Lv X; Seki T; Zhang Y; Jing X; Wu J; Du Q; He X; Fan Y; Li X; Kondo M; Yoshihara M; Qian H; Shi L; Zhu P; Xu Y; Yang Y; Cheng T; Cao Y
Article: BLOOD. 2022;139(20):3040-3057
Critical role of Lama4 for hematopoiesis regeneration and acute myeloid leukemia progression
Cai H; Kondo M; Sandhow L; Xiao P; Johansson A-S; Sasaki T; Zawacka-Pankau J; Tryggvason K; Ungerstedt J; Walfridsson J; Ekblom M; Qian H
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:880668
FOXO Dictates Initiation of B Cell Development and Myeloid Restriction in Common Lymphoid Progenitors
Pena-Perez L; Kharazi S; Frengen N; Krstic A; Bouderlique T; Hauenstein J; He M; Somuncular E; Li Wang X; Dahlberg C; Gustafsson C; Johansson A-S; Walfridsson J; Kadri N; Woll P; Kierczak M; Qian H; Westerberg L; Luc S; Mansson R
Article: EMBO MOLECULAR MEDICINE. 2020;12(3):e10419
Ribonucleotide reductase inhibitors suppress SAMHD1 ara-CTPase activity enhancing cytarabine efficacy
Rudd SG; Tsesmetzis N; Sanjiv K; Paulin CBJ; Sandhow L; Kutzner J; Myrberg IH; Bunten SS; Axelsson H; Zhang SM; Rasti A; Makela P; Coggins SA; Tao S; Suman S; Branca RM; Mermelekas G; Wiita E; Lee S; Walfridsson J; Schinazi RF; Kim B; Lehtio J; Rassidakis GZ; Tamm KP; Warpman-Berglund U; Heyman M; Grander D; Lehmann S; Lundback T; Qian H; Henter J-I; Schaller T; Helleday T; Herold N
Article: NATURE. 2019;567(7747):234-238
A radical switch in clonality reveals a stem cell niche in the epiphyseal growth plate
Newton PT; Li L; Zhou B; Schweingruber C; Hovorakova M; Xie M; Sun X; Sandhow L; Artemov AV; Ivashkin E; Suter S; Dyachuk V; El Shahawy M; Gritli-Linde A; Bouderlique T; Petersen J; Mollbrink A; Lundeberg J; Enikolopov G; Qian H; Fried K; Kasper M; Hedlund E; Adameyko I; Savendahl L; Chagin AS
Article: SCIENTIFIC REPORTS. 2018;8(1):11202
The histone chaperone NAP1L3 is required for haematopoietic stem cell maintenance and differentiation
Heshmati Y; Kharazi S; Turkoz G; Chang D; Dolatabadi EK; Bostrom J; Krstic A; Boukoura T; Wagner E; Kadri N; Mansson R; Altun M; Qian H; Walfridsson J
Article: HAEMATOLOGICA. 2018;103(7):1169-1181
The chromatin-remodeling factor CHD4 is required for maintenance of childhood acute myeloid leukemia
Heshmati Y; Turkoz G; Harisankar A; Kharazi S; Bostrom J; Dolatabadi EK; Krstic A; Chang D; Mansson R; Altun M; Qian H; Walfridsson J
Article: BLOOD ADVANCES. 2018;2(12):1480-1494
Distinct roles of mesenchymal stem and progenitor cells during the development of acute myeloid leukemia in mice
Xiao P; Sandhow L; Heshmati Y; Kondo M; Bouderlique T; Dolinska M; Johansson A-S; Sigvardsson M; Ekblom M; Walfridsson J; Qian H
Article: BLOOD ADVANCES. 2018;2(5):534-548
Sipa1 deficiency-induced bone marrow niche alterations lead to the initiation of myeloproliferative neoplasm
Xiao P; Dolinska M; Sandhow L; Kondo M; Johansson A-S; Bouderlique T; Zhao Y; Li X; Dimitriou M; Rassidakis GZ; Hellstrom-Lindberg E; Minato N; Walfridsson J; Scadden DT; Sigvardsson M; Qian H
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2017;6(10):1840-1851
Dynamic Changes in Brain Mesenchymal Perivascular Cells Associate with Multiple Sclerosis Disease Duration, Active Inflammation, and Demyelination
Iacobaeus E; Sugars RV; Andren AT; Alm JJ; Qian H; Frantzen J; Newcombe J; Alkass K; Druid H; Bottai M; Roytta M; Le Blanc K
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;490(2):378-384
Leukotriene signaling via ALOX5 and cysteinyl leukotriene receptor 1 is dispensable for in vitro growth of CD34 ⁺CD38^- stem and progenitor cells in chronic myeloid leukemia
Dolinska M; Piccini A; Wong WM; Gelali E; Johansson A-S; Klang J; Xiao P; Yektaei-Karin E; Stromberg UO; Mustjoki S; Stenke L; Ekblom M; Qian H
Article: LEUKEMIA AND LYMPHOMA. 2017;58(8):1903-1913
Modulation of leukotriene signaling inhibiting cell growth in chronic myeloid leukemia
Yektaei-Karin E; Zovko A; Nilsson A; Nasman-Glaser B; Kanter L; Radmark O; Wallvik J; Ekblom M; Dolinska M; Qian H; Stenke L
Article: STEM CELLS. 2017;35(7):1799-1814
CD36 Is a Marker of Human Adipocyte Progenitors with Pronounced Adipogenic and Triglyceride Accumulation Potential
Gao H; Volat F; Sandhow L; Galitzky J; Thuy N; Esteve D; Astrom G; Mejhert N; Ledoux S; Thalamas C; Arner P; Guillemot J-C; Qian H; Ryden M; Bouloumie A
Article: NATURE MEDICINE. 2017;23(6):692-702
Single-cell transcriptomics uncovers distinct molecular signatures of stem cells in chronic myeloid leukemia
Giustacchini A; Thongjuea S; Barkas N; Woll PS; Povinelli BJ; Booth CAG; Sopp P; Norfo R; Rodriguez-Meira A; Ashley N; Jamieson L; Vyas P; Anderson K; Segerstolpe A; Qian H; Olsson-Stromberg U; Mustjoki S; Sandberg R; Jacobsen SEW; Mead AJ
Article: BLOOD. 2017;129(16):2266-2279
Gain-of-function SAMD9L mutations cause a syndrome of cytopenia, immunodeficiency, MDS, and neurological symptoms
Tesi B; Davidsson J; Voss M; Rahikkala E; Holmes TD; Chiang SCC; Komulainen-Ebrahim J; Gorcenco S; Nilsson AR; Ripperger T; Kokkonen H; Bryder D; Fioretos T; Henter J-I; Mottonen M; Niinimaki R; Nilsson L; Pronk CJ; Puschmann A; Qian H; Uusimaa J; Moilanen J; Tedgard U; Cammenga J; Bryceson YT
Article: ELIFE. 2017;6:e25902
Oriented clonal cell dynamics enables accurate growth and shaping of vertebrate cartilage
Kaucka M; Zikmund T; Tesarova M; Gyllborg D; Hellander A; Jaros J; Kaiser J; Petersen J; Szarowska B; Newton PT; Dyachuk V; li L; Qian H; Johansson A-S; Mishina Y; Currie JD; Tanaka EM; Erickson A; Dudley A; Brismar H; Southam P; Coen E; Chen M; Weinstein LS; Hampl A; Arenas E; Chagin AS; Fried K; Adameyko I
Article: THE FASEB JOURNAL. 2017;31(3):1067-1084
Superficial cells are self-renewing chondrocyte progenitors, which form the articular cartilage in juvenile mice
Li L; Newton PT; Bouderlique T; Sejnohova M; Zikmund T; Kozhemyakina E; Xie M; Krivanek J; Kaiser J; Qian H; Dyachuk V; Lassar AB; Warman ML; Barenius B; Adameyko I; Chagin AS
Article: STEM CELLS TRANSLATIONAL MEDICINE. 2016;5(11):1485-1495
Type 1 Diabetes Mellitus Donor Mesenchymal. Stromal Cells Exhibit Comparable Potency to Healthy Controls In Vitro
Davies LC; Alm JJ; Heldring N; Moll G; Gavin C; Batsis I; Qian H; Sigvardsson M; Nilsson B; Kyllonen LE; Salmela KT; Carlsson P-O; Korsgren O; Le Blanc K
Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2015;48:31-41
Immune challenge by intraperitoneal administration of lipopolysaccharide directs gene expression in distinct blood-brain barrier cells toward enhanced prostaglandin E₂ signaling
Vasilache AM; Qian H; Blomqvist A
Article: ADVANCED FUNCTIONAL MATERIALS. 2015;25(25):3907-3915
Chondroitin Sulfate-Coated DNA-Nanoplexes Enhance Transfection Efficiency by Controlling Plasmid Release from Endosomes: A New Insight into Modulating Nonviral Gene Transfection
Yan H; Oommen OP; Yu D; Hilborn J; Qian H; Varghese OP
Article: STEM CELLS AND DEVELOPMENT. 2015;24(12):1405-1414
Amniotic Fluid-A Source for Clinical Therapeutics in the Newborn?
Ekblad A; Qian H; Westgren M; Le Blanc K; Fossum M; Gotherstrom C
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(46):33449-33461
Early B-cell Factor 1 Regulates the Expansion of B-cell Progenitors in a Dose-dependent Manner
Ahsberg J; Ungerback J; Strid T; Welinder E; Stjernberg J; Larsson M; Qian H; Sigvardsson M
Article: MOLECULAR AND CELLULAR BIOLOGY. 2013;33(4):661-677
Molecular Characterization of Prospectively Isolated Multipotent Mesenchymal Progenitors Provides New Insight into the Cellular Identity of Mesenchymal Stem Cells in Mouse Bone Marrow
Qian H; Badaloni A; Chiara F; Stjernberg J; Polisetti N; Nihlberg K; Consalez GG; Sigvardsson M
Article: STEM CELLS. 2013;31(2):360-371
Expression of Integrin α2 Receptor in Human Cord Blood CD34+CD38-CD90+Stem Cells Engrafting Long-Term in NOD/SCID-IL2Rγ_cnull Mice
Wong WM; Sigvardsson M; Astrand-Grundstrom I; Hogge D; Larsson J; Qian H; Ekblom M
Article: ENDOCRINOLOGY. 2012;153(10):4849-4861
Lipopolysaccharide-Induced Fever Depends on Prostaglandin E2 Production Specifically in Brain Endothelial Cells
Engstrom L; Ruud J; Eskilsson A; Larsson A; Mackerlova L; Kugelberg U; Qian H; Vasilache AM; Larsson P; Engblom D; Sigvardsson M; Jonsson J-I; Blomqvist A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(39):15871-15876
Single-cell analysis of early B-lymphocyte development suggests independent regulation of lineage specification and commitment in vivo
Zandi S; Ahsberg J; Tsapogas P; Stjernberg J; Qian H; Sigvardsson M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(31):25795-25807
Primary Mesenchymal Stem and Progenitor Cells from Bone Marrow Lack Expression of CD44 Protein
Qian H; Le Blanc K; Sigvardsson M
Article: BLOOD. 2011;118(5):1283-1290
IL-7 mediates Ebf-1-dependent lineage restriction in early lymphoid progenitors
Tsapogas P; Zandi S; Ahsberg J; Zetterblad J; Welinder E; Jonsson JI; Mansson R; Qian H; Sigvardsson M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(47):36275-36284
Interleukin-7-induced Stat-5 Acts in Synergy with Flt-3 Signaling to Stimulate Expansion of Hematopoietic Progenitor Cells
Ahsberg J; Tsapogas P; Qian H; Zetterblad J; Zandi S; Mansson R; Jonsson J-I; Sigvardsson M
Article: BMC GENOMICS. 2010;11:108
Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
Zetterblad J; Qian H; Zandi S; Mansson R; Lagergren A; Hansson F; Bryder D; Paulsson N; Sigvardsson M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;390(3):883-886
Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions
Qian H; Johansson S; McCourt P; Smedsrod B; Ekblom M; Johansson S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2009;383(3):336-339
Fetal hepatic expression of 5-lipoxygenase activating protein is confined to colonizing hematopoietic cells
Strid T; Karlsson C; Soderstrom M; Zhang J; Qian H; Sigvardsson M; Hammarstrom S
Article: JOURNAL OF IMMUNOLOGY. 2008;180(4):2045-2053
Kit regulates maintenance of quiescent hematopoietic stem cells
Thoren LA; Liuba K; Bryder D; Nygren JM; Jensen CT; Qian H; Antonchuk J; Jacobsen S-EW
Article: CELL STEM CELL. 2007;1(6):671-684
Critical role of thrombopoietin in maintaining adult quiescent hematopoietic stem cells
Qian H; Buza-Vidas N; Hyland CD; Jensen CT; Antonchuk J; Mansson R; Thoren LA; Ekblorn M; Alexander WS; Jacobsen SEW
Article: BLOOD. 2007;110(7):2399-2407
Distinct roles of integrins α6 and α4 in homing of fetal liver hematopoietic stem and progenitor cells
Qian H; Georges-Labouesse E; Nystrom A; Domogatskaya A; Tryggvason K; Jacobsen SEW; Ekblom M
Article: IMMUNITY. 2007;26(4):407-419
Molecular evidence for hierarchical transcriptional lineage priming in fetal and adult stem cells and multipotent progenitors
Mansson R; Hultquist A; Luc S; Yang L; Anderson K; Kharazi S; Al-Hashmi S; Liuba K; Thoren L; Adolfsson J; Buza-Vidas N; Qian H; Soneji S; Enver T; Sigvardsson M; Jacobsen SEW
Article: GENES & DEVELOPMENT. 2006;20(15):2018-2023
Cytokines regulate postnatal hematopoietic stem cell expansion: opposing roles of thrombopoietin and LNK
Buza-Vidas N; Antonchuk J; Qian H; Mansson R; Luc S; Zandi S; Anderson K; Takaki S; Nygren JM; Jensen CT; Jacobsen SEW
Article: BLOOD. 2006;107(9):3503-3510
Contribution of α6 integrins to hematopoietic stem and progenitor cell homing to bone marrow and collaboration with α4 integrins
Qian H; Tryggvason K; Jacobsen SE; Ekblom M
Article: ZHONGGUO YING YONG SHENG LI XUE ZA ZHI = ZHONGGUO YINGYONG SHENGLIXUE ZAZHI = CHINESE JOURNAL OF APPLIED PHYSIOLOGY. 2004;20(3):254-258
[Noradrenaline is involved in cardiovascular responses induced by intracerebroventricular injection substance P in rabbits].
Qian H; Yang L-P; Liu A-D; Tian H; Wei Z-Y
Article: ZHONGGUO YING YONG SHENG LI XUE ZA ZHI = ZHONGGUO YINGYONG SHENGLIXUE ZAZHI = CHINESE JOURNAL OF APPLIED PHYSIOLOGY. 2001;17(4):326-395
[The role substance P in cardiovascular response to intracerebroventricular acetylcholine in rabbit].
Yang LP; Qian H; Liu AD
Article: ACTA PHARMACOLOGICA SINICA. 2001;22(4):349-354
Central norepinephrine pathways are involved in cardiovascular response to intracerebroventricular substance P
Qian H; Yang LP; Wei ZY; Liu AD; Tian H; Yang SF
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Alla övriga publikationer

Preprint: BIORXIV. 2022
Identification of GTF2IRD1 as a novel transcription factor essential for acute myeloid leukemia
Heshmati Y; Türköz G; Dimitriou M; Harisankar A; Boström J; Cai H; Kadri N; Altun M; Qian H; Walfridsson J
Letter: HAEMATOLOGICA. 2020;105(3):e102-e106
Progression of progenitor B-cell leukemia is associated with alterations of the bone marrow micro-environment
Ahsberg J; Xiao P; Okuyama K; Somasundaram R; Strid T; Qian H; Sigvardsson M
Editorial comment: STEM CELLS INTERNATIONAL. 2018;2018:4879379-3
The Stem Cell Niche: Interactions between Stem Cells and Their Environment
Pennings S; Liu KJ; Qian H
Meeting abstract: BLOOD. 2016;128(22):27
Laminin α4 Deficiency Results in Impaired Hematopoietic Recovery Accompanied with Altered Bone Marrow Niche after Myelosuppression
Kondo M; Xiao P; Sandhow L; Dolinska M; Bouderlique T; Johansson A-S; Qian H
Meeting abstract: BLOOD. 2016;128(22):1488
Mesenchymal Stromal Cells, Instigator or Suppressor for the Development of MLL-AF9 Induced Acute Myeloid Leukemia?
Xiao P; Heshmati Y; Bouderlique T; Kondo M; Dolinska M; Sandhow L; Johansson A-S; Walfridsson J; Qian H
Letter: LEUKEMIA. 2016;30(6):1399-1402
A novel Lin-CD34+CD38-integrin α2-bipotential megakaryocyte-erythrocyte progenitor population in the human bone marrow
Wong WM; Dolinska M; Sigvardsson M; Ekblom M; Qian H
Book chapter: TISSUE ENGINEERING. 2014;p. 427-469
Chapter 13 Clinical Grade Production of Mesenchymal Stromal Cells
Alm JJ; Qian H; Le Blanc K

Forskningsbidrag

Dissecting molecular interplay between leukemic stem cells and their niche in acute and chronic myeloid leukemia
Swedish Research Council
1 January 2023 - 31 December 2025
Stromal dysfunction and neuroinflammation - experimental and clinical studies
Swedish Research Council
1 January 2023 - 31 December 2026
Bone marrow niche contribution to leukemic stem cell persistence and treatment failure in chronic myeloid leukemia – towards increased treatment-free remissions
Swedish Research Council
1 January 2020 - 31 December 2022
Utvecklingsbanor för humana B-celler
Knut and Alice Wallenberg Foundation
1 January 2020 - 1 January 2025
The search for new therapeutic strategies targeting the bone marrow environment for the treatment of myeloid leukemia
Swedish Cancer Society
1 January 2018
The search for new therapeutic strategies targeting the bone marrow environment for the treatment of myeloid leukemia
Swedish Cancer Society
1 January 2017
What role do the mesenchymal stem cells play in the bone marrow in blood cancer - a way to develop new treatment strategies
Swedish Cancer Society
1 January 2016
What role do the mesenchymal stem cells play in the bone marrow in blood cancer - a way to develop new treatment strategies
Swedish Cancer Society
1 January 2015
The importance of stromal bone marrow stem cells for blood cancer and normal blood formation
Swedish Cancer Society
1 January 2014
Understanding organ-specific homing of bone marrow-derived primary mesenchymal stem cells
Swedish Research Council
1 January 2013 - 31 December 2015

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