Henrik Spåhr

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE COMMUNICATIONS. 2020;11(1):2932
Distinct pre-initiation steps in human mitochondrial translation
Khawaja A; Itoh Y; Remes C; Spahr H; Yukhnovets O; Hoefig H; Amunts A; Rorbach J
Article: MOLECULAR CELL. 2019;76(5):784-796.e6
Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria
Nicholls TJ; Spahr H; Jiang S; Siira SJ; Koolmeister C; Sharma S; Kauppila JHK; Jiang M; Kaever V; Rackham O; Chabes A; Falkenberg M; Filipovska A; Larsson N-G; Gustafsson CM
Article: NUCLEIC ACIDS RESEARCH (NAR). 2019;47(17):9386-9399
C6orf203 is an RNA-binding protein involved in mitochondrial protein synthesis
Gopalakrishna S; Pearce SF; Dinan AM; Schober FA; Cipullo M; Spahr H; Khawaja A; Maffezzini C; Freyer C; Wredenberg A; Atanassov I; Firth AE; Rorbach J
Article: NATURE COMMUNICATIONS. 2018;9(1):2212
Modular ssDNA binding and inhibition of telomerase activity by designer PPR proteins.
Spåhr H; Chia T; Lingford JP; Siira SJ; Cohen SB; Filipovska A; Rackham O
Article: CELL REPORTS. 2018;23(1):127-142
PTCD1 Is Required for 16S rRNA Maturation Complex Stability and Mitochondrial Ribosome Assembly
Perks KL; Rossetti G; Kuznetsova I; Hughes LA; Ermer JA; Ferreira N; Busch JD; Rudler DL; Spahr H; Schoendorf T; Shearwood A-MJ; Viola HM; Siira SJ; Hool LC; Milenkovic D; Larsson N-G; Rackham O; Filipovska A
Article: NATURE COMMUNICATIONS. 2017;8(1):1532
LRPPRC-mediated folding of the mitochondrial transcriptome
Siira SJ; Spahr H; Shearwood A-MJ; Ruzzenente B; Larsson N-G; Rackham O; Filipovska A
Article: NUCLEIC ACIDS RESEARCH (NAR). 2016;44(14):6868-6882
SLIRP stabilizes LRPPRC via an RRM-PPR protein interface
Spahr H; Rozanska A; Li X; Atanassov I; Lightowlers RN; Chrzanowska-Lightowlers ZMA; Rackham O; Larsson N-G
Article: NATURE COMMUNICATIONS. 2016;7:11884
Loss of the RNA-binding protein TACO1 causes late-onset mitochondrial dysfunction in mice
Richman TR; Spahr H; Ermer JA; Davies SMK; Viola HM; Bates KA; Papadimitriou J; Hool LC; Rodger J; Larsson N-G; Rackham O; Filipovska A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2015;112(36):11288-11293
Cross-strand binding of TFAM to a single mtDNA molecule forms the mitochondrial nucleoid
Kukat C; Davies KM; Wurm CA; Spahr H; Bonekamp NA; Kuehl I; Joos F; Polosa PL; Park CB; Posse V; Falkenberg M; Jakobs S; Kuehlbrandt W; Larsson N-G
Article: PLOS GENETICS. 2015;11(8):e1005423
SLIRP Regulates the Rate of Mitochondrial Protein Synthesis and Protects LRPPRC from Degradation
Lagouge M; Mourier A; Lee HJ; Spahr H; Wai T; Kukat C; Ramos ES; Motori E; Busch JD; Siira S; Kremmer E; Filipovska A; Larsson N-G
Article: MOLECULAR CELL. 2015;59(2):258-269
Crystal Structure of a Transcribing RNA Polymerase II Complex Reveals a Complete Transcription Bubble.
Barnes CO; Calero M; Malik I; Graham BW; Spahr H; Lin G; Cohen AE; Brown IS; Zhang Q; Pullara F; Trakselis MA; Kaplan CD; Calero G
Article: HUMAN MOLECULAR GENETICS. 2014;23(23):6345-6355
A human mitochondrial poly(A) polymerase mutation reveals the complexities of post-transcriptional mitochondrial gene expression.
Wilson WC; Hornig-Do H-T; Bruni F; Chang JH; Jourdain AA; Martinou J-C; Falkenberg M; Spåhr H; Larsson N-G; Lewis RJ; Hewitt L; Baslé A; Cross HE; Tong L; Lebel RR; Crosby AH; Chrzanowska-Lightowlers ZMA; Lightowlers RN
Article: PLOS GENETICS. 2014;10(2):e1004110
NSUN4 Is a Dual Function Mitochondrial Protein Required for Both Methylation of 12S rRNA and Coordination of Mitoribosomal Assembly
Metodiev MD; Spahr H; Polosa PL; Meharg C; Becker C; Altmueller J; Habermann B; Larsson N-G; Ruzzenente B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2014;443(1):7-12
The UbL protein UBTD1 stably interacts with the UBE2D family of E2 ubiquitin conjugating enzymes.
Uhler JP; Spåhr H; Farge G; Clavel S; Larsson N-G; Falkenberg M; Samuelsson T; Gustafsson CM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2013;288(22):15510-15519
The Leucine-rich Pentatricopeptide Repeat-containing Protein (LRPPRC) Does Not Activate Transcription in Mammalian Mitochondria
Harmel J; Ruzzenente B; Terzioglu M; Spahr H; Falkenberg M; Larsson N-G
Article: PROTEIN EXPRESSION AND PURIFICATION. 2013;87(2):111-119
A general path for large-scale solubilization of cellular proteins: from membrane receptors to multiprotein complexes.
Pullara F; Guerrero-Santoro J; Calero M; Zhang Q; Peng Y; Spåhr H; Kornberg GL; Cusimano A; Stevenson HP; Santamaria-Suarez H; Reynolds SL; Brown IS; Monga SPS; Van Houten B; Rapić-Otrin V; Calero G; Levine AS
Article: PLOS GENETICS. 2013;9(1):e1003178
MTERF3 Regulates Mitochondrial Ribosome Biogenesis in Invertebrates and Mammals
Wredenberg A; Lagouge M; Bratic A; Metodiev MD; Spahr H; Mourier A; Freyer C; Ruzzenente B; Tain L; Groenke S; Baggio F; Kukat C; Kremmer E; Wibom R; Polosa PL; Habermann B; Partridge L; Park CB; Larsson N-G
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(38):15253-15258
Structure of the human MTERF4-NSUN4 protein complex that regulates mitochondrial ribosome biogenesis
Spahr H; Habermann B; Gustafsson CM; Larsson N-G; Hallberg BM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2011;108(33):13534-13539
Super-resolution microscopy reveals that mammalian mitochondrial nucleoids have a uniform size and frequently contain a single copy of mtDNA.
Kukat C; Wurm CA; Spåhr H; Falkenberg M; Larsson N-G; Jakobs S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;397(3):386-390
Structure of mitochondrial transcription termination factor 3 reveals a novel nucleic acid-binding domain
Spahr H; Samuelsson T; Hallberg BM; Gustafsson CM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2009;106(23):9185-9190
Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution.
Spåhr H; Calero G; Bushnell DA; Kornberg RD
Article: GENES & DEVELOPMENT. 2005;19(19):2301-2306
RNA Pol II subunit Rpb7 promotes centromeric transcription and RNAi-directed chromatin silencing
Djupedal I; Portoso M; Spåhr H; Bonilla C; Gustafsson CM; Allshire RC; Ekwall K
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2003;278(51):51301-51306
Mediator influences Schizosaccharomyces pombe RNA polymerase II-dependent transcription in vitro
Spåhr H; Khorosjutina O; Baraznenok V; Linder T; Samuelsen CO; Hermand D; Mäkelä TP; Holmberg S; Gustafsson CM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2003;100(11):6422-6427
TRAP230/ARC240 and TRAP240/ARC250 Mediator subunits are functionally conserved through evolution
Samuelsen CO; Baraznenok V; Khorosjutina O; Spåhr H; Kieselbach T; Holmberg S; Gustafsson CM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(21):11985-11990
Analysis of Schizosaccharomyces pombe Mediator reveals a set of essential subunits conserved between yeast and metazoan cells
Spåhr H; Samuelsen CO; Baraznenok V; Ernest I; Huylebroeck D; Remacle JE; Samuelsson T; Kieselbach T; Holmberg S; Gustafsson CM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(2):1351-1356
Purification and characterization of RNA polymerase II holoenzyme from Schizosaccharomyces pombe.
Spåhr H; Bève J; Larsson T; Bergström J; Karlsson KA; Gustafsson CM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(47):30851-30854
Identification of new mediator subunits in the RNA polymerase II holoenzyme from Saccharomyces cerevisiae.
Gustafsson CM; Myers LC; Beve J; Spåhr H; Lui M; Erdjument-Bromage H; Tempst P; Kornberg RD
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Thesis / dissertation: 2004
The transcription machinery in schizosaccharomyces pombe and its regulation
Spåhr, Henrik

Anställningar

Senior Forskningsspecialist, Medicinsk biokemi och biofysik, Karolinska Institutet, 2016-

Examina och utbildning

MEDICINE DOKTORSEXAMEN, Inst medicinsk näringslära - nedl 060101, Karolinska Institutet, 2004

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