Helene Rundqvist

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE MEDICINE. 2024;:1-10

Supervised, structured and individualized exercise in metastatic breast cancer: a randomized controlled trial

Hiensch AE; Depenbusch J; Schmidt ME; Monninkhof EM; Pelaez M; Clauss D; Gunasekara N; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Sweegers MG; Fremd C; Altena R; Gorecki M; Bijlsma R; van Leeuwen-Snoeks L; ten Bokkel Huinink D; Sonke G; Lahuerta A; Mann GB; Francis PA; Richardson G; Malter W; van der Wall E; Aaronson NK; Senkus E; Urruticoechea A; Zopf EM; Bloch W; Stuiver MM; Wengstrom Y; Steindorf K; May AM
Article: SCIENTIFIC REPORTS. 2024;14(1):15333

Five-year follow-up of the OptiTrain trial on concurrent resistance and high-intensity interval training during chemotherapy for patients with breast cancer

Anandavadivelan P; Mijwel S; Wiklander M; Kjoe PLM; Luijendijk M; Bergh J; Rundqvist H; Wengstrom Y
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2024;42(16_suppl):11121

Cost-utility analysis of a supervised exercise program for patients with metastatic breast cancer in the PREFERABLE-EFFECT randomized controlled trial (RCT).

Hiensch AE; Schouten A; Monninkhof EM; Schmidt M; Clauss D; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Van Der Wall E; Aaronson NK; Senkus-Konefka E; Urruticoechea A; Bloch W; Zopf E; Stuiver MM; Wengstrom Y; Steindorf K; van der Meulen M; May AM
Journal article: CANCER RESEARCH. 2024;84(9_Supplement):gs02-10-gs02-10

Abstract GS02-10: Effects of a structured and individualized exercise program on fatigue and health-related quality of life in patients with metastatic breast cancer: the multinational randomized controlled PREFERABLE-EFFECT study

May A; Hiensch A; Depenbusch J; Schmidt M; Monninkhof E; Pelaez M; Clauss D; Zimmer P; Belloso J; Trevaskis M; Rundqvist H; Wiskemann J; Muller J; Fremd C; Altena R; Kufel-Grabowska J; Bijlsma R; van Leeuwen-Snoeks L; Bokkel-Huinink DT; Sonke G; Mann B; Francis P; Richardson G; Álvarez I; Malter W; Van der Wall E; Aaronson N; Senkus E; Urriticoechea A; Zopf E; Bloch W; Stuiver M; Wengström Y; Steindorf K
Journal article: ESMO OPEN. 2024;9:103328

269MO The effects of exercise on sexual health and breast cancer-specific symptom burden in women with metastatic breast cancer: Results of the multinational randomized PREFERABLE-EFFECT trial

Schmidt ME; Hiensch A; Depenbusch J; Clauss D; Monninkhof E; Pelaez M; Gunasekara N; Lachowicz M; Trevaskis M; Rundqvist H; Müller J; Wiskemann J; van der Wall E; Aaronson N; Urruticoechea A; Zopf E; Stuiver M; Wengström Y; May AM; Steindorf K
Journal article: PHYSIOLOGY. 2024;39(S1):1733

Myocardial Blood Flow in Newly Diagnosed Breast Cancer Patients at Rest and During Exercise

Heinonen I; Koivula T; Uurasmaa T-M; Han C; Maaniitty T; Latifi S; Lempiäinen S; Kalliokoski K; Sundberg C-J; Rundqvist H; Anttila K; Minn H; Knuuti J
Article: JAMA NETWORK OPEN. 2024;7(4):e244386

Functional Limitations and Exercise Intolerance in Patients With Post-COVID Condition

Tryfonos A; Pourhamidi K; Joernaker G; Engvall M; Eriksson L; Elhallos S; Asplund N; Mandic M; Sundblad P; Sepic A; Rullman E; Hyllienmark L; Rundqvist H; Lundberg TR; Gustafsson T
Article: BRITISH JOURNAL OF SPORTS MEDICINE. 2024;58(7):366-372

Association between change in cardiorespiratory fitness and prostate cancer incidence and mortality in 57 652 Swedish men

Bolam KA; Bojsen-Moller E; Wallin P; Paulsson S; Lindwall M; Rundqvist H; Ekblom-Bak E
Journal article: EUROPEAN JOURNAL OF CANCER. 2024;200:113605

1 Oral Effects of exercise on fatigue and health-related quality of life (HRQoL) in patients with metastatic breast cancer (mBC) – do the positive effects apply to all? The multinational randomized controlled PREFERABLE-EFFECT study

Hiensch A; Depenbusch J; Schmidt M; Clauss D; Lizarraga NA; Trevaskis M; Rundqvist H; Wiskemann J; Mueller J; Gunasekara N; Lachowicz M; van der Wall E; Aaronson N; Senkus E; Urruticoechea A; Zopf E; Stuiver M; Wengstrom Y; Steindorf K; May A; Consortium OBOTP
Article: FRONTIERS IN PHYSIOLOGY. 2024;15:1347347

Voluntary wheel running reduces tumor growth and increases capillarity in the heart during doxorubicin chemotherapy in a murine model of breast cancer

Uurasmaa T-M; Ricardo C; Autio A; Heinonen IHA; Rundqvist H; Anttila K
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1394420

The effect of exercise and disease status on mobilization of anti-tumorigenic and pro-tumorigenic immune cells in women with breast cancer

Koivula T; Lempiaeinen S; Neuvonen J; Norha J; Hollmen M; Sundberg CJ; Rundqvist H; Minn H; Rinne P; Heinonen I
Article: FRONTIERS IN IMMUNOLOGY. 2024;15:1293723

The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy

Bargiela D; Cunha PP; Velica P; Krause LCM; Brice M; Barbieri L; Gojkovic M; Foskolou IP; Rundqvist H; Johnson RS
Journal article: FRONTIERS IN IMMUNOLOGY. 2024;15:1293723

The factor inhibiting HIF regulates T cell differentiation and anti-tumour efficacy.

Bargiela D; Cunha PP; Veliça P; Krause LCM; Brice M; Barbieri L; Gojkovic M; Foskolou IP; Rundqvist H; Johnson RS
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2023;55(9S):967-968

The Effect Of Acute Exercise On Immune Cell Counts In Newly Diagnosed Breast Cancer Patients

Koivula T; Lempiäinen S; Rinne P; Rannikko JH; Hollmén M; Sundberg CJ; Rundqvist H; Minn H; Heinonen I
Article: NPJ MICROGRAVITY. 2023;9(1):40

Myeloid cell infiltration in skeletal muscle after combined hindlimb unloading and radiation exposure in mice

Emanuelsson EB; Baselet B; Neefs M; Baatout S; Proesmans B; Daenen L; Sundberg CJ; Rundqvist H; Fernandez-Gonzalo R
Article: JAMA NETWORK OPEN. 2023;6(6):e2321102

Association Between Cardiorespiratory Fitness and Cancer Incidence and Cancer-Specific Mortality of Colon, Lung, and Prostate Cancer Among Swedish Men

Ekblom-Bak E; Bojsen-Moller E; Wallin P; Paulsson S; Lindwall M; Rundqvist H; Bolam KA
Article: SCIENTIFIC REPORTS. 2023;13(1):6561

The effect of acute exercise on circulating immune cells in newly diagnosed breast cancer patients

Koivula T; Lempiainen S; Rinne P; Rannikko JH; Hollmen M; Sundberg CJ; Rundqvist H; Minn H; Heinonen I
Article: BMJ OPEN. 2023;13(3):e071304

EffectiveNess of a multimodal preHAbilitation program in patieNts with bladder canCEr undergoing radical cystectomy: protocol of the ENHANCE multicentre randomised controlled trial

Akdemir E; Sweegers MG; Vrieling A; Rundqvist H; Meijer RP; Leliveld-Kors AM; van der Heijden AG; Rutten VC; Koldewijn EL; Bos SD; Wijburg CJ; Marcelissen TAT; Bongers BC; Retel VP; van Harten WH; May AM; Groen WG; Stuiver MM
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1101433

Lactate exposure shapes the metabolic and transcriptomic profile of CD8+T cells

Barbieri L; Velica P; Gameiro PA; Cunha PP; Foskolou IP; Rullman E; Bargiela D; Johnson RS; Rundqvist H
Article: LAKARTIDNINGEN. 2022;119:22070

[Physical activity supports cardiovascular fitness and muscle strength and has positive effects on quality of life among cancer survivors].

Rundqvist H; Johnson A; Onerup A; Altena R; Wengström Y
Article: TRIALS. 2022;23(1):610

Design of a multinational randomized controlled trial to assess the effects of structured and individualized exercise in patients with metastatic breast cancer on fatigue and quality of life: the EFFECT study

Hiensch AE; Monninkhof EM; Schmidt ME; Zopf EM; Bolam KA; Aaronson NK; Belloso J; Bloch W; Clauss D; Depenbusch J; Lachowicz M; Pelaez M; Rundqvist H; Senkus E; Stuiver MM; Trevaskis M; Urruticoechea A; Rosenberger F; van der Wall E; de Wit GA; Zimmer P; Wengstrom Y; Steindorf K; May AM
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2022;132(6):1448-1459

A HIF-1 signature dominates the attenuation in the human skeletal muscle transcriptional response to high-intensity interval training

Norrbom JM; Ydfors M; Lovric A; Perry CGR; Rundqvist H; Rullman E
Article: JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE. 2022;13(2):1151-1163

Exercise reduces intramuscular stress and counteracts muscle weakness in mice with breast cancer

Mader T; Chaillou T; Alves ES; Jude B; Cheng AJ; Kenne E; Mijwel S; Kurzejamska E; Vincent CT; Rundqvist H; Lanner JT
Journal article: JCSM RAPID COMMUNICATIONS. 2022;5(1):117-129

Voluntary exercise influences metastatic organotropism in a murine colorectal cancer model

Wijler LA; Raats DAE; Verheem A; Otter AMD; Rundqvist H; van Dijk M; May AM; Kranenburg O
Article: FRONTIERS IN PHYSIOLOGY. 2022;13:1078512

Acute exercise mobilizes CD8⁺ cytotoxic T cells and NK cells in lymphoma patients

Koivula T; Lempiaeinen S; Rinne P; Hollmen M; Sundberg CJ; Rundqvist H; Minn H; Heinonen I
Article: FRONTIERS IN IMMUNOLOGY. 2022;13:837669

Vitamin B6 Metabolism Determines T Cell Anti-Tumor Responses

Bargiela D; Cunha PP; Velica P; Foskolou IP; Barbieri L; Rundqvist H; Johnson RS
Article: CIRCULATION RESEARCH. 2021;128(11):1694-1707

Perivascular Macrophages Regulate Blood Flow Following Tissue Damage

Vagesjo E; Parv K; Ahl D; Seignez C; Herrera Hidalgo C; Giraud A; Leite C; Korsgren O; Wallen H; Juusola G; Hakovirta HH; Rundqvist H; Essand M; Holm L; Johnson RS; Thalin C; Korpisalo P; Christoffersson G; Phillipson M
Article: CANCER IMMUNOLOGY RESEARCH. 2021;9(4):401-414

Modified Hypoxia-Inducible Factor Expression in CD8⁺ T Cells Increases Antitumor Efficacy

Velica P; Cunha PP; Vojnovic N; Foskolou IP; Bargiela D; Gojkovic M; Rundqvist H; Johnson RS
Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2021;53(3):496-504

Inflammation Mediates Exercise Effects on Fatigue in Patients with Breast Cancer

Hiensch AE; Mijwel S; Bargiela D; Wengstrom Y; May AM; Rundqvist H
Article: CARDIO-ONCOLOGY. 2021;7(1):7

High intensity exercise during breast cancer chemotherapy-effects on long-term myocardial damage and physical capacity-data from the OptiTrain RCT

Ansund J; Mijwel S; Bolam KA; Altena R; Wengstrom Y; Rullman E; Rundqvist H
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:633586

Oxygen-Mediated Suppression of CD8+T Cell Proliferation by Macrophages: Role of Pharmacological Inhibitors of HIF Degradation

Gojkovic M; Cunha PP; Darmasaputra GS; Barbieri L; Rundqvist H; Velica P; Johnson RS
Article: ELIFE. 2020;9:e59996

Cytotoxic T-cells mediate exercise-induced reductions in tumor growth

Rundqvist H; Velica P; Barbieri L; Gameiro PA; Bargiela D; Gojkovic M; Mijwel S; Reitzner SM; Wulliman D; Ahlstedt E; Ule J; Ostman A; Johnson RS
Article: BLOOD ADVANCES. 2020;4(18):4483-4493

The S enantiomer of 2-hydroxyglutarate increases central memory CD8 populations and improves CAR-T therapy outcome

Foskolou IP; Barbieri L; Vernet A; Bargiela D; Cunha PP; Velica P; Suh E; Pietsch S; Matuleviciute R; Rundqvist H; McIntyre D; Smith KGC; Johnson RS
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):336

Cd8+ T-cell Depletion Abolishes The Anti-metastatic Effects Of Voluntary Running In A Mouse Model Of Breast Cancer

Rundqvist H; Barbieri L; Velica P; Mijwel S; Östman A; Johnson R
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7S):923

Combined Effects Of Unloading And Radiation On Skeletal Muscle In Mice

Fernandez-Gonzalo R; Hansson B; Emanuelsson E; Baselet B; Moreels M; Neefs M; Baatout S; Rundqvist H
Article: ACTA PHYSIOLOGICA. 2020;229(2):e13461

Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE)

Gojkovic M; Darmasaputra GS; Velica P; Rundqvist H; Johnson RS
Article: CELL DEATH DISCOVERY. 2020;6(1):42

Interleukin-6 derived from cancer-associated fibroblasts attenuates the p53 response to doxorubicin in prostate cancer cells

Cheteh EH; Sarne V; Ceder S; Bianchi J; Augsten M; Rundqvist H; Egevad L; Ostman A; Wiman KG
Article: ONCOLOGIST. 2020;25(1):23-32

Effects of Exercise on Chemotherapy Completion and Hospitalization Rates: The OptiTrain Breast Cancer Trial

Mijwel S; Bolam KA; Gerrevall J; Foukakis T; Wengstrom Y; Rundqvist H
Article: SCIENTIFIC REPORTS. 2019;9(1):10246

Acute and chronic hypoxia differentially predispose lungs for metastases

Reiterer M; Colaco R; Emrouznejad P; Jensen A; Rundqvist H; Johnson RS; Branco C
Article: BREAST CANCER RESEARCH AND TREATMENT. 2019;175(3):637-648

Two-year follow-up of the OptiTrain randomised controlled exercise trial

Bolam KA; Mijwel S; Rundqvist H; Wengstrom Y
Journal article: 2019

Lactate Potentiates Differentiation and Expansion of Cytotoxic T Cells

Rundqvist H; Velica P; Barbieri L; Gameiro P; Cunha PP; Gojkovic M; Bargiela D; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Perez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson RS
Article: NATURE COMMUNICATIONS. 2019;10(1):2110

Ribosome biogenesis during cell cycle arrest fuels EMT in development and disease

Prakash V; Carson BB; Feenstra JM; Dass RA; Sekyrova P; Hoshino A; Petersen J; Guo Y; Parks MM; Kurylo CM; Batchelder JE; Haller K; Hashimoto A; Rundqivst H; Condeelis JS; Allis CD; Drygin D; Nieto MA; Andang M; Percipalle P; Bergh J; Adameyko I; Farrants A-KO; Hartman J; Lyden D; Pietras K; Blanchard SC; Vincent CT
Article: JOURNAL OF CANCER SURVIVORSHIP. 2019;13(2):244-256

High-intensity exercise during chemotherapy induces beneficial effects 12months into breast cancer survivorship

Mijwel S; Jervaeus A; Bolam KA; Norrbom J; Bergh J; Rundqvist H; Wengstrom Y
Article: FASEB JOURNAL. 2018;32(10):5495-5505

Exercise training during chemotherapy preserves skeletal muscle fiber area, capillarization, and mitochondrial content in patients with breast cancer

Mijwel S; Cardinale DA; Norrbom J; Chapman M; Ivarsson N; Wengstrom Y; Sundberg CJ; Rundqvist H
Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;169(1):93-103

Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial

Mijwel S; Backman M; Bolam KA; Olofsson E; Norrbom J; Bergh J; Sundberg CJ; Wengstrom Y; Rundqvist H
Article: CELL METABOLISM. 2018;27(4):898-913.e7

The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia

Sim J; Cowburn AS; Palazon A; Madhu B; Tyrakis PA; Macias D; Bargiela DM; Pietsch S; Gralla M; Evans CE; Kittipassorn T; Chey YCJ; Branco CM; Rundqvist H; Peet DJ; Johnson RS
Article: EJNMMI RESEARCH. 2018;8(1):25

Treatment response assessment with (R)-[¹¹CPAQ PET in the MMTV-PyMT mouse model of breast cancer

Tegnebratt T; Lu L; Eksborg S; Chireh A; Damberg P; Nikkhou-Aski S; Foukakis T; Rundqvist H; Holmin S; Kuiper RV; Samen E
Article: BREAST CANCER RESEARCH AND TREATMENT. 2018;168(1):79-93

Adding high-intensity interval training to conventional training modalities: optimizing health-related outcomes during chemotherapy for breast cancer: the OptiTrain randomized controlled trial

Mijwel S; Backman M; Bolam KA; Jervaeus A; Sundberg CJ; Margolin S; Browall M; Rundqvist H; Wengstrom Y
Article: FRONTIERS IN PHYSIOLOGY. 2018;9:1624

Glycolytic Response to Inflammation Over Time: Role of Myeloid HIF-1alpha

Fitzpatrick SF; Gojkovic M; Macias D; Tegnebratt T; Lu L; Samen E; Rundqvist H; Johnson RS
Article: CANCER CELL. 2017;32(5):669-683.e5

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Palazon A; Tyrakis PA; Macias D; Velica P; Rundqvist H; Fitzpatrick S; Vojnovic N; Phan AT; Loman N; Hedenfalk I; Hatschek T; Lovrot J; Foukakis T; Goldrath AW; Bergh J; Johnson RS
Article: ACTA PHYSIOLOGICA. 2017;220(3):361-369

Cutaneous exposure to hypoxia does not affect skin perfusion in humans

Siebenmann C; Keramidas ME; Rundqvist H; Mijwel S; Cowburn AS; Johnson RS; Eiken O
Article: MOLECULAR AND CELLULAR BIOLOGY. 2017;37(13):e00630-e00616

A Molecular Mechanism To Switch the Aryl Hydrocarbon Receptor from a Transcription Factor to an E3 Ubiquitin Ligase

Luecke-Johansson S; Gralla M; Rundqvist H; Ho JC; Johnson RS; Gradin K; Poellinger L
Article: CELL DEATH & DISEASE. 2017;8(6):e2848

Human cancer-associated fibroblasts enhance glutathione levels and antagonize drug-induced prostate cancer cell death

Cheteh EH; Augsten M; Rundqvist H; Bianchi J; Sarne V; Egevad L; Bykov VJN; Ostman A; Wiman KG
Article: BIOLOGY OPEN. 2017;6(5):688-697

Modelling pulmonary microthrombosis coupled to metastasis: distinct effects of thrombogenesis on tumorigenesis

Evans CE; Palazon A; Sim J; Tyrakis PA; Prodger A; Lu X; Chan S; Bendahl P-O; Belting M; Von Euler L; Rundqvist H; Johnson RS; Branco C
Article: ONCOTARGET. 2017;8(9):15085-15100

Boosting the hypoxic response in myeloid cells accelerates resolution of fibrosis and regeneration of the liver in mice

Kantari-Mimoun C; Krzywinska E; Castells M; Milien C; Klose R; Meinecke A-K; Lemberger U; Mathivet T; Gojkovic M; Schroedter K; Oesterreicher C; Fandrey J; Rundqvist H; Stockmann C
Article: LAKARTIDNINGEN. 2017;114:EFHC

[Aerobic and muscle-strengthening exercise should be recommended].

Rundqvist H; Wengström Y
Article: BMC CANCER. 2017;17(1):100

Optitrain: a randomised controlled exercise trial for women with breast cancer undergoing chemotherapy

Wengstrom Y; Bolam KA; Mijwel S; Sundberg CJ; Backman M; Browall M; Norrbom J; Rundqvist H
Article: REHABILITATION ONCOLOGY. 2016;34(4):137-143

Validation of 2 Submaximal Cardiorespiratory Fitness Tests in Patients With Breast Cancer Undergoing Chemotherapy.

Mijwel S; Cardinale D; Ekblom-Bak E; Sundberg CJ; Wengström Y; Rundqvist H
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2016;4:99

Autocrine VEGF Isoforms Differentially Regulate Endothelial Cell Behavior

Yamamoto H; Rundqvist H; Branco C; Johnson RS
Article: EXPERIMENTAL PHYSIOLOGY. 2016;101(1):28-32

Skeletal muscle hypoxia-inducible factor-1 and exercise

Lindholm ME; Rundqvist H
Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2016;108(3)

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells (vol 107, djv209, 2015)

Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2015;107(10):djv209

Role of Tumor Pericytes in the Recruitment of Myeloid-Derived Suppressor Cells

Hong J; Tobin NP; Rundqvist H; Li T; Lavergne M; Garcia-Ibanez Y; Qin H; Paulsson J; Zeitelhofer M; Adzemovic MZ; Nilsson I; Roswall P; Hartman J; Johnson RS; Ostman A; Bergh J; Poljakovic M; Genove G
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2015;119(4):374-384

Rapidly elevated levels of PGC-1α-b protein in human skeletal muscle after exercise: exploring regulatory factors in a randomized controlled trial

Gidlund E-K; Ydfors M; Appel S; Rundqvist H; Sundberg CJ; Norrbom J
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2015;34(1):62

Confrontation of fibroblasts with cancer cells in vitro: gene network analysis of transcriptome changes and differential capacity to inhibit tumor growth

Alexeyenko A; Alkasalias T; Pavlova T; Szekely L; Kashuba V; Rundqvist H; Wiklund P; Egevad L; Csermely P; Korcsmaros T; Guven H; Klein G
Journal article: ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY. 2015;35(suppl_1)

Abstract 184: Pulmonary Microvascular Thrombosis Enhances Extravasation via Myeloid Hypoxia-Inducible Factors

Evans CE; Branco-Price C; Prodger A; Palazon A; Tyrakis P; Rundqvist H; Bendahl P-O; Belting M; Johnson RS
Article: EPIGENETICS. 2014;9(12):1557-1569

An integrative analysis reveals coordinated reprogramming of the epigenome and the transcriptome in human skeletal muscle after training

Lindholm ME; Marabita F; Gomez-Cabrero D; Rundqvist H; Ekstrom TJ; Tegner J; Sundberg CJ
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2014;307(3):R248-R255

Negative regulation of HIF in skeletal muscle of elite endurance athletes: a tentative mechanism promoting oxidative metabolism

Lindholm ME; Fischer H; Poellinger L; Johnson RS; Gustafsson T; Sundberg CJ; Rundqvist H
Article: EJNMMI RESEARCH. 2014;4(1):17

Visualization of angiogenesis during cancer development in the polyoma middle T breast cancer model: molecular imaging with (R)-[¹¹C]PAQ

Samen E; Lu L; Mulder J; Thorell J-O; Damberg P; Tegnebratt T; Holmgren L; Rundqvist H; Stone-Elander S
Journal article: CANCER PREVENTION RESEARCH. 2013;6(11_Supplement):a65

Abstract A65: Effect of voluntary running on metastasis in a mouse model of breast cancer

Rundqvist H; Mijwel S; Ahlstedt E; Lindholm C; Strell C; Roswall P; Pietras K; Johnson R; Ostman A
Article: PLOS ONE. 2013;8(7):e67579

Effect of Acute Exercise on Prostate Cancer Cell Growth

Rundqvist H; Augsten M; Stromberg A; Rullman E; Mijwel S; Kharaziha P; Panaretakis T; Gustafsson T; Ostman A
Article: BLOOD. 2012;119(24):5931-5942

Aberrant mural cell recruitment to lymphatic vessels and impaired lymphatic drainage in a murine model of pulmonary fibrosis

Meinecke A-K; Nagy N; Lago GD; Kirmse S; Klose R; Schroedter K; Zimmermann A; Helfrich I; Rundqvist H; Theegarten D; Anhenn O; Orian-Rousseau V; Johnson RS; Alitalo K; Fischer JW; Fandrey J; Stockmann C
Article: CELL DEATH & DISEASE. 2012;3(1):e262

Targeting of distinct signaling cascades and cancer-associated fibroblasts define the efficacy of Sorafenib against prostate cancer cells

Kharaziha P; Rodriguez P; Li Q; Rundqvist H; Bjoerklund A-C; Augsten M; Ullen A; Egevad L; Wiklund P; Nilsson S; Kroemer G; Grander D; Panaretakis T
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2011;301(6):E1092-E1098

Alternative splice variant PGC-1α-b is strongly induced by exercise in human skeletal muscle

Norrbom J; Sallstedt EK; Fischer H; Sundberg CJ; Rundqvist H; Gustafsson T
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2010;42(10):11-12

Expression Of An Alternative Pgc-1· Transcript In Human Skeletal Muscle

Sällstedt E-K; Norrbom J; Fischer H; Sundberg CJ; Rundqvist H; Gustafsson T
Journal article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2010;42(10):71

Negative Regulation Of HIF-1 Through FIH And SIRT6 In Elite Athletes And With Training

Klintberg M; Rundqvist H; Gustafsson T; Tonkonogi M; Sundberg CJ
Article: ACTA PHYSIOLOGICA. 2010;198(1):71-79

Training response of mitochondrial transcription factors in human skeletal muscle

Norrbom J; Wallman SE; Gustafsson T; Rundqvist H; Jansson E; Sundberg CJ
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2009;161(3):427-434

Activation of the erythropoietin receptor in human skeletal muscle

Rundqvist H; Rullman E; Sundberg CJ; Fischer H; Eisleitner K; Stahlberg M; Sundblad P; Jansson E; Gustafsson T
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2009;106(3):804-812

Endurance exercise activates matrix metalloproteinases in human skeletal muscle

Rullman E; Norrbom J; Stromberg A; Wagsater D; Rundqvist H; Haas T; Gustafsson T
Article: AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY. 2007;293(5):R2059-R2069

HIF-1α in endurance training:: suppression of oxidative metabolism

Mason SD; Rundqvist H; Papandreou I; Duh R; McNulty WJ; Howlett RA; Olfert IM; Sundberg CJ; Denko NC; Poellinger L; Johnson RS
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2007;103(3):1012-1020

The influence of physical training on the angiopoietin and VEGF-A systems in human skeletal muscle

Gustafsson T; Rundqvist H; Norrbom J; Rullman E; Jansson E; Sundberg CJ
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2007;102(6):2346-2351

A single bout of exercise activates matrix metalloproteinase in human skeletal muscle

Rullman E; Rundqvist H; Wagsater D; Fischer H; Eriksson P; Sundberg CJ; Jansson E; Gustafsson T
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2005;98(6):2137-2146

VEGF-A splice variants and related receptor expression in human skeletal muscle following submaximal exercise

Gustafsson T; Ameln H; Fischer H; Sundberg CJ; Timmons JA; Jansson E
Article: FASEB JOURNAL. 2005;19(6):1009-1011

Physiological activation of hypoxia inducible factor-1 in human skeletal muscle

Ameln H; Gustafsson T; Sundberg CJ; Okamoto K; Jansson E; Poellinger L; Makino Y
Article: JOURNAL OF APPLIED PHYSIOLOGY. 2004;96(1):189-194

PGC-1α mRNA expression is influenced by metabolic perturbation in exercising human skeletal muscle

Norrbom J; Sundberg CJ; Ameln H; Kraus WE; Jansson E; Gustafsson T
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Preprint: BIORXIV. 2023

A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue

Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Conference publication: ACTA PHYSIOLOGICA. 2023;239

Effect of running wheel exercise on heart and skeletal muscle during doxorubicin treatment of breast cancer bearing mice

Uurasmaa T-M; Bourdin P; Latifi S; Roivainen A; Rundqvist H; Autio A; Heinonen I; Anttila K
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2023;55(9):967-968

The Effect Of Acute Exercise On Immune Cell Counts In Newly Diagnosed Breast Cancer Patients

Koivula T; Lempiainen S; Rinne P; Rannikko JH; Hollmen M; Sundberg CJ; Rundqvist H; Minn H; Heinonen I
Preprint: BIORXIV. 2021

Lactate regulation of activation in CD8+ T cells

Barbieri L; Veliça P; Gameiro P; Cunha P; Foskolou I; Bargiela D; Rundqvist H; Johnson R
Editorial comment: ACTA PHYSIOLOGICA. 2021;231(1):e13494

Deregulated hypoxic response in myeloid cells: A model for high-altitude pulmonary oedema (HAPE) Response

Gojkovic M; Velica P; Rundqvist H; Johnson RS
Preprint: BIORXIV. 2020

Modified Hypoxia Inducible Factor expression in CD8+ T cells increases anti-tumor efficacy

Veliça P; Cunha PP; Vojnovic N; Foskolou IP; Bargiela D; Gojkovic M; Rundqvist H; Johnson RS
Review: ACTA PHYSIOLOGICA. 2020;229(2):e13400

Doxorubicin-induced skeletal muscle atrophy: Elucidating the underlying molecular pathways

Hiensch AE; Bolam KA; Mijwel S; Jeneson JAL; Huitema ADR; Kranenburg O; van der Wall E; Rundqvist H; Wengstrom Y; May AM
Corrigendum: SCIENTIFIC REPORTS. 2020;10(1):1627

Acute and chronic hypoxia differentially predispose lungs for metastases (vol 9, 10246, 2019)

Reiterer M; Colaco R; Emrouznejad P; Jensen A; Rundqvist H; Johnson RS; Branco C
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):923

Combined Effects Of Unloading And Radiation On Skeletal Muscle In Mice

Fernandez-Gonzalo R; Hansson B; Emanuelsson E; Baselet B; Moreels M; Neefs M; Baatout S; Rundqvist H
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):336

Cd8+T-cell Depletion Abolishes The Anti-metastatic Effects Of Voluntary Running In A Mouse Model Of Breast Cancer

Rundqvist H; Barbieri L; Velica P; Mijwel S; Ostman A; Johnson R
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2019;51(6):900

Inflammation Mediates The Effects Of Exercise On Fatigue In Patients With Breast Cancer Undergoing Chemotherapy

Hiensch AE; Mijwel S; Wengstrom Y; May AM; Rundqvist H
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2019;51(6):881

Effects Of Exercise During Chemotherapy On Hospitalization And Chemotherapy Completion: The OptiTrain Breast Cancer Trial

Mijwel S; Bolam KA; Wengstrom Y; Rundqvist H
Conference publication: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2019;51(6):880

The 24-month Follow-up Of The Optitrain Exercise Rct For Women With Breast Cancer Undergoing Chemotherapy

Bolam KA; Mijwel S; Holowko N; Bergh J; Rundqvist H; Wengstrom Y
Preprint: BIORXIV. 2019

Lactate potentiates differentiation and expansion of cytotoxic T cells

Rundqvist H; Veliça P; Barbieri L; Gameiro P; Cunha P; Gojkovic M; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Pérez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson R
Preprint: SSRN ELECTRONIC JOURNAL. 2019

Lactate Potentiates Differentiation and Expansion of Cytotoxic T Cells

Rundqvist H; Velica P; Barbieri L; Gameiro P; Cunha PP; Gojkovic M; Bargiela D; Mijwel S; Ahlstedt E; Foskolou I; Ruiz-Perez MV; Arsenian-Henriksson M; Ule J; Östman A; Johnson RS
Review: INTEGRATIVE CANCER THERAPIES. 2018;17(1):16-30

Physical Activity During and After Adjuvant Treatment for Breast Cancer: An Integrative Review of Women's Experiences

Browall M; Mijwel S; Rundqvist H; Wengstrom Y
Conference publication: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. 2018;48:44-45

Perivascular macrophages regulate blood flow following tissue damage

Vagesjo E; Seignez C; Christoffersson G; Herrera-Hidalgo C; Giraud A; Korsgren O; Rundqvist H; Essand M; Holm L; Johnson R; Phillipson M
Editorial comment: ACTA PHYSIOLOGICA. 2018;222(1)

Hypoxic sprint exercise as a complement to the "Live High-Train Low" regimen

Rundqvist H; Gustafsson T
Meeting abstract: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2017;49(5):335

Concurrent Aerobic and Resistance Training Prevents Physical Fatigue in Patients with Breast Cancer during Chemotherapy

Mijwel S; Backman M; Bolam KA; Sundberg CJ; Norrbom J; Bergh J; Wengstrom Y; Rundqvist H
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):256-257

They activated CD8+T-cells in low oxygen. What happens next will blow your mind!

Velica P; Rundqvist H; Gojkovic M; Johnson RS
Conference publication: ACTA PHYSIOLOGICA. 2017;219:43

No local or systemic effects of cutaneous exposure to hypobaric hypoxia in humans

Siebenmann C; Keramidas M; Rundqvist H; Mijwel S; Cowburn A; Johnson R; Eiken O
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):309

Myeloid hypoxia leads to reduced metastatic success

Gojkovic M; Velica P; Darmasaputra G; Rundqvist H; Johnson R
Conference publication: CANCER RESEARCH. 2016;76:c10

The role of FIH in macrophage function

Gojkovic M; Rundqvist H; Velica P; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:a12

The immune composition of a spontaneous mouse breast cancer

Velica P; Rundqvist H; Gojkovic M; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:836

Effect of voluntary running on metastasis in a mouse model of breast cancer

Mijwel S; Rundqvist H; Lindholm C; Strell C; Roswall P; Pietras K; Johnson RS; Ostman A
Conference publication: CANCER RESEARCH. 2016;76:a21

Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa

Branco C; Rundqvist H; Colaco R; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:a19

Pulmonary microthrombosis enhances tumorigenesis via myeloid hypoxia-inducible factors

Evans CE; Palazon A; Sim J; Tyrakis PA; Bendahl P-O; Belting M; Rundqvist H; Branco C; Johnson RS
Conference publication: CANCER RESEARCH. 2016;76:pr03

Hypoxia preconditioning affects metastatic seeding and proliferation through vascular and immune function, in a process regulated by lung endothelial HIFa

Branco C; Rundqvist H; Colaco R; Johnson RS
Conference publication: BREAST. 2016;29:S1-S2

Physical activity/exercise and cancer

Rundqvist H
Conference publication: BREAST CANCER RESEARCH AND TREATMENT. 2016;159(1):195

Endothelial HIF-a modulate cancer metastatic potential by affecting vascular permeability and pro-metastatic macrophage infiltration

Branco C; Evans C; Colaco R; Rundqvist H; Johnson R
Conference publication: EUROPEAN JOURNAL OF CANCER. 2015;51:S300-S301

Validation of two submaximal exercise tests in breast cancer patients undergoing chemotherapy treatment

Mijwel S; Cardinale D; Bak EE; Sundberg CJ; Wengstrom Y; Rundqvist H
Conference publication: CLINICAL & EXPERIMENTAL METASTASIS. 2015;32(3):234-235

Myeloid cell derived vascular endothelial growth factor promotes pulmonary metastasis by increasing endothelial permeability

Rundqvist H; Stockmann C; Ponte R; Doedens A; Johnson RS
Conference publication: JOURNAL OF THORACIC ONCOLOGY. 2015;10(9):S394-S395

Microthrombosis Enhances Extravasation via Myeloid HypoxiaInducible Factors

Evans CE; Prodger A; Branco-Price C; Palazon A; Tyrakis P; Sim J; Rundqvist H; Bendahl P-O; Belting M; Johnson RS
Conference publication: ACTA PHYSIOLOGICA. 2014;211:58

Ca²⁺ and free radicals in disease-induced skeletal muscle weakness

Cheng A; Ivarsson N; Mijwell S; Rundqvist H; Andersson DC; Rassier D; Lanner JT
Conference publication: ACTA PHYSIOLOGICA. 2014;211:76

Exercise improves specific force in slow-twitch skeletal muscles from mice carrying mammary gland tumors

Ivarsson N; Mijwel S; Fedotovskaya O; Westerblad H; Ostman A; Rundqvist H; Lanner JT
Conference publication: ANTICANCER RESEARCH. 2014;34(10):6145-6146

STROMAL HYPOXIA AND METASTASIS IN BREAST CANCER

Rundqvist H; Stockmann C; Branco-Price C; Doedens A; Johnson RS
Review: JOURNAL OF INTERNAL MEDICINE. 2013;274(2):105-112

Tumour oxygenation: implications for breast cancer prognosis

Rundqvist H; Johnson RS
Review: UPSALA JOURNAL OF MEDICAL SCIENCES. 2012;117(2):187-195

Fibroblasts-a key host cell type in tumor initiation, progression, and metastasis

Strell C; Rundqvist H; Ostman A
Conference publication: FASEB JOURNAL. 2012;26:1142.7

Voluntary exercise reduces cachexia and improves muscle function in mice carrying mammary gland tumors

Ivarsson N; Rundqvist H; Ostman A; Westerblad H
Meeting abstract: BIOPHYSICAL JOURNAL. 2012;102(3):364A

Endurance Exercise Increases Force Production in Mouse Fast-Twitch Muscles

Ivarsson N; Rundqvist H; Lanner JT
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2010;345:121-139

Hypoxia and Metastasis in Breast Cancer

Rundqvist H; Johnson RS
Thesis / dissertation: 2008

Skeletal muscle HIF-1 and exercise

Rundqvist, Helene
Conference publication: FASEB JOURNAL. 2008;22:753.10

PGC-1[alpha] and upstream regulators in human skeletal muscle

Norrbom J; Rundqvist H; Sundberg CJ; Jansson E; Gustafsson T
Conference publication: FASEB JOURNAL. 2008;22:753.11

HIF-1 specific prolyl hydroxylases in elite athletes

Rundqvist H; Klintberg M; Norrbom J; Gustafsson T; Sundberg CJ
Conference publication: FASEB JOURNAL. 2008;22:753.12

Protein and mRNA expression of mitochondrial transcription factors TFB1M, TFB2M and TFAM in elite athletes

Sundberg CJ; Norrbom J; Rundqvist H; Wallman S; Jansson E; Gustafsson T
Conference publication: FASEB JOURNAL. 2007;21(5):A576

The influence of physical training on the angiopoietin and VEGF-A systems in human skeletal muscle

Gustafsson T; Rundqvist H; Norrbom J; Rullman E; Jansson E; Sundberg CJ
Conference publication: FASEB JOURNAL. 2007;21(5):A576

MMP mRNA expression in the skeletal muscle following a 5 week training program

Stromberg A; Rullman E; Rundqvist H; Norrbom J; Gustafsson T
Conference publication: FASEB JOURNAL. 2007;21(5):A575

A single bout of exercise activates matrix metalloproteinase in human skeletal muscle

Rullman E; Rundqvist H; Wagsater D; Fischer H; Eriksson P; Sundberg C-J; Jansson E; Gustafsson T
Conference publication: FASEB JOURNAL. 2007;21(6):A938

Erythropoietin and its receptor in human skeletal muscle

Rundqvist H; Sundberg CJ; Rullman E; Stahlberg M; Sundblad P; Jansson E; Gustafsson T
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Forskningsbidrag

EFFECT- Exercise For Fatigue in AdvancEd Cancer PaTients- An RCT

Swedish Research Council

1 January 2019 - 31 December 2021
Tumor hypoxia and the immune system – protective or harmful?

Swedish Research Council

1 January 2017 - 31 December 2019
Hypoxia and Inflammation in Breast Cancer Metastasis

Swedish Research Council

1 January 2014 - 31 December 2016
Notification of the use of return grants for granted postdoctoral grants

Swedish Research Council

1 March 2010 - 31 August 2010

Anställningar

Forskare, Laboratoriemedicin, Karolinska Institutet, 2019-

Examina och utbildning

MEDICINE DOKTORSEXAMEN, Institutionen för fysiologi och farmakologi, Karolinska Institutet, 2008

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

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