Helena Karlström

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: NEURON. 2023;111(23):3745-3764.e7
Molecular anatomy of adult mouse leptomeninges
Pietila R; Del Gaudio F; He L; Vazquez-Liebanas E; Vanlandewijck M; Muhl L; Mocci G; Bjornholm KD; Lindblad C; Fletcher-Sandersjoo A; Svensson M; Thelin EP; Liu J; van Voorden AJ; Torres M; Antila S; Xin L; Karlstrom H; Storm-Mathisen J; Bergersen LH; Moggio A; Hansson EM; Ulvmar MH; Nilsson P; Makinen T; Mae MA; Alitalo K; Proulx ST; Engelhardt B; McDonald DM; Lendahl U; Andrae J; Betsholtz C
Article: CELL REPORTS: METHODS. 2023;3(3):100431
A robust and efficient microvascular isolation method for multimodal characterization of the mouse brain vasculature
Bjornholm KD; Del Gaudio F; Li H; Li W; Vazquez-Liebanas E; Mae MA; Lendahl U; Betsholtz C; Nilsson P; Karlstrom H; Vanlandewijck M
Article: EMBO MOLECULAR MEDICINE. 2023;15(2):e16556
Active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Oliveira DV; Coupland KG; Shao W; Jin S; Del Gaudio F; Wang S; Fox R; Rutten JW; Sandin J; Zetterberg H; Lundkvist J; Oberstein SAL; Lendahl U; Karlstrom H
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2022;26(3):880-892
γ-Secretase modulators show selectivity for γ-secretase-mediated amyloid precursor protein intramembrane processing
Weber TA; Lundkvist J; Wanngren J; Kvartsberg H; Jin S; Larssen P; Wu D; Oliveira DV; Minta K; Brinkmalm G; Zetterberg H; Blennow K; Nordvall G; Winblad B; Portelius E; Karlstrom H
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:812808
Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro
Oliveira DV; Svensson J; Zhong X; Biverstal H; Chen G; Karlstrom H
Article: NEUROLOGY-GENETICS. 2021;7(3):e584
Novel Cysteine-Sparing Hypomorphic NOTCH3 A1604T Mutation Observed in a Family With Migraine and White Matter Lesions
Arnardottir S; Del Gaudio F; Klironomos S; Braune E-B; Lombrana AA; Oliveira DV; Jin S; Karlstrom H; Lendahl U; Sjostrand C
Article: DISEASE MODELS & MECHANISMS. 2021;14(2):dmm046300
The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression
Wu D; Wang S; Oliveira DV; Del Gaudio F; Vanlandewijck M; Lebouvier T; Betsholtz C; Zhao J; Jin S; Lendahl U; Karlstrom H
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(6):3016-3024
Differences in proliferation rate between CADASIL and control vascular smooth muscle cells are related to increased TGFβ expression
Panahi M; Mesri NY; Samuelsson E-B; Coupland KG; Forsell C; Graff C; Tikka S; Winblad B; Viitanen M; Karlstrom H; Sundstrom E; Behbahani H
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2018;22(2):823-833
Specificity of presenilin-1-and presenilin-2-dependent γ-secretases towards substrate processing
Stanga S; Vrancx C; Tasiaux B; Marinangeli C; Karlstrom H; Kienlen-Campard P
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2016;20(9):1686-1695
Mitofusin-2 knockdown increases ER-mitochondria contact and decreases amyloid β-peptide production
Leal NS; Schreiner B; Pinho CM; Filadi R; Wiehager B; Karlstroem H; Pizzo P; Ankarcrona M
Article: FEBS OPEN BIO. 2014;4:393-406
Changed membrane integration and catalytic site conformation are two mechanisms behind the increased Aβ42/Aβ40 ratio by presenilin 1 familial Alzheimer-linked mutations
Wanngren J; Lara P; Ojemalm K; Maioli S; Moradi N; Chen L; Tjernberg LO; Lundkvist J; Nilsson I; Karlstrom H
Article: PLOS ONE. 2013;8(5):e63962
Visualizing Active Enzyme Complexes Using a Photoreactive Inhibitor for Proximity Ligation - Application on γ-Secretase
Schedin-Weiss S; Inoue M; Teranishi Y; Yamamoto NG; Karlstrom H; Winblad B; Tjernberg LO
Article: JOURNAL OF NEUROSCIENCE. 2012;32(48):17297-17305
Alzheimer's Disease: Presenilin 2-Sparing γ-Secretase Inhibition Is a Tolerable Aβ Peptide-Lowering Strategy
Borgegard T; Gustavsson S; Nilsson C; Parpal S; Klintenberg R; Berg A-L; Rosqvist S; Serneels L; Svensson S; Olsson F; Jin S; Yan H; Wanngren J; Jureus A; Ridderstad-Wollberg A; Wollberg P; Stockling K; Karlstrom H; Malmberg A; Lund J; Arvidsson PI; De Strooper B; Lendahl U; Lundkvist J
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(39):32640-32650
Second Generation γ-Secretase Modulators Exhibit Different Modulation of Notch β and Aβ Production
Wanngren J; Ottervald J; Parpal S; Portelius E; Stromberg K; Borgegard T; Klintenberg R; Jureus A; Blomqvist J; Blennow K; Zetterberg H; Lundkvist J; Rosqvist S; Karlstrom H
Article: JOURNAL OF ALZHEIMERS DISEASE. 2012;31(3):527-536
Biochemical Studies of Poly-T Variants in the Alzheimer's Disease Associated TOMM40 Gene
Hedskog L; Brohede J; Wiehager B; Pinho CM; Revathikumar P; Lilius L; Glaser E; Graff C; Karlstrom H; Ankarcrona M
Journal article: ALZHEIMERS & DEMENTIA. 2012;8(4S_Part_7):p242
O2‐04‐06: The role of presenilin 1 familial Alzheimer's disease mutations for gamma‐secretase activity and changed structural conformation
Vasquez PL; Wanngren J; Maioli S; Tjernberg L; Winblad B; Lundkvist J; Nilsson I; Karlström H
Journal article: ALZHEIMERS & DEMENTIA. 2012;8(4S_Part_8):p294
P2‐089: Functional analysis of a nicastrin‐independent gamma‐secretase complex containing an artificial double mutation in presenilin 1
Pamrén A; Wanngren J; Vasquez PL; Öjemalm K; Maioli S; Nilsson I; Karlström H
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2011;15(10):2150-2163
γ-secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ₄₂/Aβ₄₀ ratio
Hedskog L; Petersen CAH; Svensson AI; Welander H; Tjernberg LO; Karlstrom H; Ankarcrona M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(36):31153-31158
Mutations in Nicastrin Protein Differentially Affect Amyloid β-Peptide Production and Notch Protein Processing
Pamren A; Wanngren J; Tjernberg LO; Winblad B; Bhat R; Naslund J; Karlstrom H
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_12):s410-s411
P2‐314: Molecular studies of nicastrin in the γ‐Secretase complex using an artificial nicastrin independent presenilin 1 double mutant
Svensson A; Wanngren J; Vasquez PL; Geiger K; Nilsson I; Karlström H
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_12):s411-s412
P2‐317: Impact of different γ‐secretase modulators on Notch‐1 Abeta‐like peptide (Nβ) formation
Wanngren J; Ottervald J; Parpal S; Olsson F; Strömberg K; Blomqvist J; Wollberg P; Malinowsky D; Winblad B; Lundkvist J; Rosqvist S; Karlström H
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_6):s202
P1‐287: Positional cloning identifies SIGMAR1 gene as a causative locus for FTLD‐MND in a large Australian pedigree
Kwok J; Luty A; Dobson‐Stone C; Loy C; Brooks W; Karlström H; Halliday G; Schofield P
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;404(1):564-568
Minor contribution of presenilin 2 for γ -secretase activity in mouse embryonic fibroblasts and adult mouse brain
Franberg J; Svensson AI; Winblad B; Karlstrom H; Frykman S
Article: ANNALS OF NEUROLOGY. 2010;68(5):639-649
Sigma Nonopioid Intracellular Receptor 1 Mutations Cause Frontotemporal Lobar Degeneration-Motor Neuron Disease
Luty AA; Kwok JBJ; Dobson-Stone C; Loy CT; Coupland KG; Karlstrom H; Sobow T; Tchorzewska J; Maruszak A; Barcikowska M; Panegyres PK; Zekanowski C; Brooks WS; Williams KL; Blair IP; Mather KA; Sachdev PS; Halliday GM; Schofield PR
Article: PLOS ONE. 2010;5(3):e9772
γ-Secretase Dependent Production of Intracellular Domains Is Reduced in Adult Compared to Embryonic Rat Brain Membranes
Franberg J; Karlstrom H; Winblad B; Tjernberg LO; Frykman S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(12):8527-8536
The Large Hydrophilic Loop of Presenilin 1 Is Important for Regulating β-Secretase Complex Assembly and Dictating the Amyloid β Peptide (Aβ) Profile without Affecting Notch Processing
Wanngren J; Franberg J; Svensson AI; Laudon H; Olsson F; Winblad B; Liu F; Naslund J; Lundkvist J; Karlstrom H
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_19):t618
P3‐328: Cleavage of endogenous substrates by γ‐secretase in rat brain membranes
Frånberg J; Wiehager B; Winblad B; Karlström H; Tjernberg LO; Frykman S
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_22):t729
P4‐198: Molecular studies of the presenilin protein interactions to γ‐secretase inhibitors and modulators
Hultström J; Winblad B; Lundkvist J; Näslund J; Karlström H
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_19):t623
P3‐347: Molecular studies of the gamma‐secretase complex: Focus on nicastrin
Svensson A; Winblad B; Bhat R; Näslund J; Karlström H
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_8):t246-t247
P1‐136: The effect of gamma secretase inhibitors on modulating differentiation in human embryonic stem cell‐derived neural cells
Nat R; Winblad B; Karlström H
Journal article: ALZHEIMERS & DEMENTIA. 2008;4(4S_Part_6):t189-t190
O4‐03–05: A molecular investigation of different domains in the gamma‐secretase complex for their substrate interaction
Karlström H; Hultström J; Svensson A; Näslund J; Winblad B
Article: NEUROREPORT. 2007;18(12):1267-1269
No association of spastic paraparesis genes in PSENI Alzheimer's disease with spastic paraparesis
Karlstrom H; Kwok JBJ; Gregory GC; Hallupp M; Brooks WS; Schofield PR
Article: JOURNAL OF NEUROCHEMISTRY. 2007;102(3):848-857
Presenilin dependence of phospholipase C and protein kinase C signaling
Dehvari N; Cedazo-Minguez A; Isacsson O; Nilsson T; Winblad B; Karlstrom H; Benedikz E; Cowburn RF
Journal article: ALZHEIMERS & DEMENTIA. 2006;2(3S_Part_1):s26
S2–03–01: Molecular studies on the Alzheimer's presenilin protein
Karlstrom H; Laudon H; Naslund J
Article: GENESIS. 2005;41(1):13-22
Mice carrying a R142C Notch 3 knock-in mutation do not develop a CADASIL-like phenotype
Lundkvist J; Zhu SW; Hansson EM; Schweinhardt P; Miao Q; Beatus P; Dannaeus K; Karlström H; Johansson CB; Viitanen M; Rozell B; Spenger C; Mohammed A; Kalimo H; Lendahl U
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):23925-23932
Functional domains in presenilin 1 -: The TYR-288 residue controls γ-secretase activity and endoproteolysis
Laudon H; Karlström H; Mathews PM; Farmery MR; Gandy SE; Lundkvist J; Lendahl U; Näslund J
Article: JOURNAL OF NEUROCHEMISTRY. 2004;89(1):44-53
Co-expressed presenilin 1 NTF and CTF form functional γ-secretase complexes in cells devoid of full-length protein
Laudon H; Mathews PM; Karlström H; Bergman A; Farmery MR; Nixon RA; Winblad B; Gandy SE; Lendahl U; Lundkvist J; Näslund J
Article: EXPERIMENTAL CELL RESEARCH. 2003;287(1):1-9
APP intracellular domain formation and unaltered signaling in the presence of familial Alzheimer's disease mutations
Bergman A; Religa D; Karlström H; Laudon H; Winblad B; Lannfelt L; Lundkvist J; Näslund J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(26):17119-17124
A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling
Karlström H; Beatus P; Dannaeus K; Chapman G; Lendahl U; Lundkvist J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(6):4014-4019
Notch receptor cleavage depends on but is not directly executed by presenilins
Taniguchi Y; Karlström H; Lundkvist J; Mizutani T; Otaka A; Vestling M; Bernstein A; Donoviel D; Lendahl U; Honjo T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(9):6763-6766
A sensitive and quantitative assay for measuring cleavage of presenilin substrates
Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
Article: SCIENCE. 2000;288(5471):1660-1663
Generalized potential of adult neural stem cells
Clarke DL; Johansson CB; Wilbertz J; Veress B; Nilsson E; Karlström H; Lendahl U; Frisén J
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Alla övriga publikationer

Preprint: BIORXIV. 2022
NOTCH3 active immunotherapy reduces NOTCH3 deposition in brain capillaries in a CADASIL mouse model
Oliveira DV; Coupland KG; Jin S; Del Gaudio F; Wang S; Fox R; Rutten JW; Sandin J; Lundkvist J; Oberstein SAJL; Lendahl U; Karlström H
Preprint: SSRN ELECTRONIC JOURNAL. 2022
A Robust and Efficient Microvascular Isolation Method for Multimodal Characterization of the Mouse Brain Vasculature
Bjørnholm KD; Del Gaudio F; Li H; Li W; Vázquez Liébanas E; Mäe MA; Lendahl U; Betsholtz C; Nilsson P; Karlström H; Vanlandewijck M
Preprint: BIORXIV. 2021
Multimodal characterization of the murine neurovascular niche using a novel microvascular isolation protocol
Bjørnholm KD; Vanlandewijck M; Del Gaudio F; Lendahl U; Nilsson P; Karlström H; Betsholtz C
Conference publication: JOURNAL OF VASCULAR RESEARCH. 2019;56:87
Characterization of a Novel CADASIL-Like Mutation in the NOTCH3 Receptor
Arnardottir S; Del Gaudio F; Lombrana AA; Oliveira DV; Karlstrom H; Lendahl U; Sjostrand C
Review: STROKE. 2018;49(11):2793-2800
Role of NOTCH3 Mutations in the Cerebral Small Vessel Disease Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy
Coupland K; Lendahl U; Karlstrom H
Review: JOURNAL OF NEUROCHEMISTRY. 2008;104(3):573-583
Variable phenotype of Alzheimer's disease with spastic paraparesis
Karlstrom H; Brooks WS; Kwok JBJ; Broe GA; Kril JJ; McCann H; Halliday GM; Schofield PR
Review: NEUROSCIENCE. 2005;133(1):59-77
Generation and phenotypic characterization of a galanin overexpressing mouse
Holmberg K; Kuteeva E; Brumovsky P; Kahl U; Karlström H; Lucas GA; Rodriguez J; Westerblad H; Hilke S; Theodorsson E; Berge OG; Lendahl U; Bartfai T; Hökfelt T
Thesis / dissertation: 2002
Notch receptor processing and CNS disease
Karlström, Helena
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S206-S207
PS1-controlled γ-secretase activity:: Definition of am minimal structural motif in the N-terminal fragment
Laudon H; Bergman A; Farmery MR; Winblad B; Naslund J; Karlstrom H; Lundkvist J; Lendahl U; Mathews P; Gandy SE
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S11
A sensitive and quantitative assay for measuring cleavage of presenilin substrates
Karlström H; Bergman A; Lendahl U; Näslund J; Lundkvist J
Conference publication: NEUROBIOLOGY OF AGING. 2002;23(1):S174
Measurement of total gamma-cleavage of C99 with mutations in the transmembrane domain by a luciferase assay
Bergman A; Religa D; Laudon H; Lannfelt L; Nüslund J; Karlström H; Lendahl U; Lundqvist J

Forskningsbidrag

Combating cerebral small vessel disease by new diagnostic tools and therapy development
Swedish Heart-Lung Foundation
1 January 2021 - 31 December 2021

Anställningar

Lektor, Neurobiologi, vårdvetenskap och samhälle, Karolinska Institutet, 2023-

Examina och utbildning

Docent, Neurobiologi, Karolinska Institutet, 2011
MEDICINE DOKTORSEXAMEN, Institutionen för cell- och molekylärbiologi, Karolinska Institutet, 2002

Artiklar

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Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI