Heinrich Schlums

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: BLOOD. 2024;144(8):873-887
Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis.
Chiang SCC; Covill LE; Tesi B; Campbell TM; Schlums H; Nejati-Zendegani J; Mördrup K; Wood S; Theorell J; Sekine T; Al-Herz W; Akar HH; Belen FB; Chan MY; Devecioglu O; Aksu T; Ifversen M; Malinowska I; Sabel M; Unal E; Unal S; Introne WJ; Krzewski K; Gilmour KC; Ehl S; Ljunggren H-G; Nordenskjöld M; Horne A; Henter J-I; Meeths M; Bryceson YT
Article: JOURNAL OF IMMUNOLOGY. 2024;212(5):868-880
KIR2DS1 and KIR2DL1-C245 Dominantly Repress NK Cell Degranulation Triggered by Monoclonal or Bispecific Antibodies, whereas Education by Uptuning Inhibitory Killer Ig-related Receptors Exerts No Advantage in Ab-dependent Cellular Cytotoxicity.
Leijonhufvud C; Sanz-Ortega L; Schlums H; Gaballa A; Andersson A; Eriksson C; Segerberg F; Uhlin M; Bryceson YT; Carlsten M
Article: IMMUNITY. 2023;56(6):1285-1302.e7
Human skin-resident CD8+T cells require RUNX2 and RUNX3 for induction of cytotoxicity and expression of the integrin CD49a
Zitti B; Hoffer E; Zheng W; Pandey RV; Schlums H; Casoni GP; Fusi I; Nguyen L; Karner J; Kokkinou E; Carrasco A; Gahm J; Ehrstrom M; Happaniemi S; Keita AV; Hedin CRH; Mjosberg J; Eidsmo L; Bryceson YT
Article: CELL REPORTS MEDICINE. 2023;4(5):101038
The single-cell transcriptional landscape of innate and adaptive lymphocytes in pediatric-onset colitis
Kokkinou E; Soini T; Pandey RV; van Acker A; Theorell J; Czarnewski P; Kvedaraite E; Vandamme N; Lourda M; Sorini C; Weigel W; Carrasco A; Tibbitt CA; Schlums H; Lindforss U; Nordenvall C; Ljunggren M; Idestrom M; Svensson M; Henter J-I; Villablanca EJ; Bryceson YT; Rolandsdotter H; Mjosberg J
Article: SCIENCE SIGNALING. 2023;16(780):eabq0752
SHP-1 localization to the activating immune synapse promotes NK cell tolerance in MHC class I deficiency
Schmied L; Luu TT; Sondergaard JN; Hald SH; Meinke S; Mohammad DK; Singh SB; Mayer C; Casoni GP; Chrobok M; Schlums H; Rota G; Truong HM; Westerberg LS; Guarda G; Alici E; Wagner AK; Kadri N; Bryceson YT; Saeed MB; Hoglund P
Article: SCIENCE IMMUNOLOGY. 2021;6(65):eabe3454
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Hetemaki I; Kaustio M; Kinnunen M; Heikkila N; Keskitalo S; Nowlan K; Miettinen S; Sarkkinen J; Glumoff V; Andersson N; Kettunen K; Vanhanen R; Nurmi K; Eklund KK; Dunkel J; Mayranpaa MI; Schlums H; Arstila TP; Kisand K; Bryceson YT; Peterson P; Otava U; Syrjanen J; Saarela J; Varjosalo M; Kekalainen E
Article: SCIENCE IMMUNOLOGY. 2021;6(57):eabc9801
The transcription factor Bcl11b promotes both canonical and adaptive NK cell differentiation
Holmes TD; Pandey RV; Helm EY; Schlums H; Han H; Campbell TM; Drashansky TT; Chiang S; Wu C-Y; Tao C; Shoukier M; Tolosa E; Von Hardenberg S; Sun M; Klemann C; Marsh RA; Lau CM; Lin Y; Sun JC; Mansson R; Cichocki F; Avram D; Bryceson YT
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2021;10(10):e1346
LIR-1 educates expanded human NK cells and defines a unique antitumor NK cell subset with potent antibody-dependent cellular cytotoxicity
Leijonhufvud C; Reger R; Segerberg F; Theorell J; Schlums H; Bryceson YT; Childs RW; Carlsten M
Article: NATURE COMMUNICATIONS. 2020;11(1):2049
Cytokines regulate the antigen-presenting characteristics of human circulating and tissue-resident intestinal ILCs
Rao A; Strauss O; Kokkinou E; Bruchard M; Tripathi KP; Schlums H; Carrasco A; Mazzurana L; Konya V; Villablanca EJ; Bjorkstrom NK; Lindforss U; Spits H; Mjosberg J
Article: PEDIATRIC BLOOD & CANCER. 2020;67(4):e28184
Diagnostic challenges for a novel SH2D1A mutation associated with X-linked lymphoproliferative disease
Torralba-Raga L; Tesi B; Chiang SCC; Schlums H; Nordenskjoeld M; Horne A; Henter J-I; Meeths M; Abdelhaleem M; Weitzman S; Bryceson Y
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2019;216(6):1280-1290
Adaptive NK cells in people exposed to Plasmodium falciparum correlate with protection from malaria
Hart GT; Tran TM; Theorell J; Schlums H; Arora G; Rajagopalan S; Sangala ADJ; Welsh KJ; Traore B; Pierce SK; Crompton PD; Bryceson YT; Long EO
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2728
Dynamic Changes in Natural Killer Cell Subset Frequencies in the Absence of Cytomegalovirus Infection
Gyurova IE; Schlums H; Sucharew H; Ambroggio L; Ochayon DE; Win HT; Bryceson YT; Bernsteins DI; Waggoner SN
Article: SCIENCE IMMUNOLOGY. 2018;3(29):eaat9781
Clonal expansion and compartmentalized maintenance of rhesus macaque NK cell subsets
Wu C; Espinoza DA; Koelle SJ; Yang D; Truitt L; Schlums H; Lafont BA; Davidson-Moncada JK; Lu R; Kaur A; Hammer Q; Li B; Panch S; Allan DA; Donahue RE; Childs RW; Romagnani C; Bryceson YT; Dunbar CE
Article: CANCER RESEARCH. 2017;77(20):5664-5675
GSK3 Inhibition Drives Maturation of NK Cells and Enhances Their Antitumor Activity
Cichocki F; Valamehr B; Bjordahl R; Zhang B; Rezner B; Rogers P; Gaidarova S; Moreno S; Tuininga K; Dougherty P; McCullar V; Howard P; Sarhan D; Taras E; Schlums H; Abbot S; Shoemaker D; Bryceson YT; Blazar BR; Wolchko S; Cooley S; Miller JS
Article: ELIFE. 2017;6:e26423
High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors
Marcais A; Marotel M; Degouve S; Koenig A; Fauteux-Daniel S; Drouillard A; Schlums H; Viel S; Besson L; Allatif O; Blery M; Vivier E; Bryceson Y; Thaunat O; Walzer T
Article: LEUKEMIA. 2017;31(5):1108-1116
Increased proportion of mature NK cells is associated with successful imatinib discontinuation in chronic myeloid leukemia
Ilander M; Olsson-Stromberg U; Schlums H; Guilhot J; Bruck O; Lahteenmaki H; Kasanen T; Koskenvesa P; Soderlund S; Hoglund M; Markevarn B; Sjalander A; Lotfi K; Dreimane A; Lubking A; Holm E; Bjoreman M; Lehmann S; Stenke L; Ohm L; Gedde-Dahl T; Majeed W; Ehrencrona H; Koskela S; Saussele S; Mahon F-X; Porkka K; Hjorth-Hansen H; Bryceson YT; Richter J; Mustjoki S
Article: BLOOD. 2017;129(14):1940-1946
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs
Corat MAF; Schlums H; Wu C; Theorell J; Espinoza DA; Sellers SE; Townsley DM; Young NS; Bryceson YT; Dunbar CE; Winkler T
Article: BLOOD. 2017;129(14):1927-1939
Adaptive NK cells can persist in patients with GATA2 mutation depleted of stem and progenitor cells
Schlums H; Jung M; Han H; Theorell J; Bigley V; Chiang SCC; Allan DSJ; Davidson-Moncada JK; Dickinson RE; Holmes TD; Hsu AP; Townsley D; Winkler T; Wang W; Aukrust P; Nordoy I; Calvo KR; Holland SM; Collin M; Dunbar CE; Bryceson YT
Article: IMMUNITY. 2017;46(2):287-300
CD49a Expression Defines Tissue-Resident CD8⁺ T Cells Poised for Cytotoxic Function in Human Skin
Cheuk S; Schlums H; Serezal IG; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Hoog C; Tjernlund A; Michaelsson J; Folkersen L; Mjosberg J; Blomqvist L; Ehrstrom M; Stahle M; Bryceson YT; Eidsmo L
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:723
Unperturbed cytotoxic lymphocyte Phenotype and Function in Myalgic encephalomyelitis/chronic Fatigue syndrome Patients
Theorell J; Bileviciute-Ljungar I; Tesi B; Schlums H; Johnsgaard MS; Asadi-Azarbaijani B; Strand EB; Bryceson YT
Article: LEUKEMIA. 2016;30(2):456-463
CD56^dimCD57⁺NKG2C⁺ NK cell expansion is associated with reduced leukemia relapse after reduced intensity HCT
Cichocki F; Cooley S; Davis Z; DeFor TE; Schlums H; Zhang B; Brunstein CG; Blazar BR; Wagner J; Diamond DJ; Verneris MR; Bryceson YT; Weisdorf DJ; Miller JS
Article: GENETIC COUNSELING. 2016;27(1):67-76
PARTIAL OCULOCUTANEOUS ALBINISM AND IMMUNODEFICIENCY SYNDROMES: TEN YEARS EXPERIENCE FROM A SINGLE CENTER IN TURKEY
Patiroglu T; Akar HH; Unal E; Chiang SC; Schlums H; Tesi B; Ozkars MY; Karakukcu M
Article: IMMUNITY. 2015;42(3):443-456
Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
Schlums H; Cichocki F; Tesi B; Theorell J; Beziat V; Holmes TD; Han H; Chiang SCC; Foley B; Mattsson K; Larsson S; Schaffer M; Malmberg K-J; Ljunggren H-G; Miller JS; Bryceson YT
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2014;211(6):1079-1091
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency
Cichocki F; Schlums H; Li H; Stache V; Holmes T; Lenvik TR; Chiang SCC; Miller JS; Meeths M; Anderson SK; Bryceson YT
Article: JOURNAL OF IMMUNOLOGY. 2013;191(6):2989-2998
Systemic Lupus Erythematosus Immune Complexes Increase the Expression of SLAM Family Members CD319 (CRACC) and CD229 (LY-9) on Plasmacytoid Dendritic Cells and CD319 on CD56^dim NK Cells
Hagberg N; Theorell J; Schlums H; Eloranta M-L; Bryceson YT; Ronnblom L
Article: BLOOD. 2011;118(22):5783-5793
Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Meeths M; Chiang SCC; Wood SM; Entesarian M; Schlums H; Bang B; Nordenskjold E; Bjorklund C; Jakovljevic G; Jazbec J; Hasle H; Holmqvist B-M; Rajic L; Pfeifer S; Rosthoj S; Sabel M; Salmi TT; Stokland T; Winiarski J; Ljunggren H-G; Fadeel B; Nordenskjold M; Henter J-I; Bryceson YT
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2011;366(1-2):106-118
Sensitive and viable quantification of inside-out signals for LFA-1 activation in human cytotoxic lymphocytes by flow cytometry
Theorell J; Schlums H; Chiang SCC; Huang TY; Tattermusch A; Wood SM; Bryceson YT
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Conference publication: BLOOD. 2022;140:8350
Comprehensive Exploration of NK Cell Education in ADCC Triggered By a Monoclonal Antibody or a Bispecific Killer Engager Molecule (BiKE)
Leijonhufvud C; Schlums H; Stikvoort A; Uhlin M; Bryceson YT; Carlsten M
Preprint: BIORXIV. 2022
Control of NK cell tolerance in MHC class I-deficiency by regulated SHP-1 localization to the activating immune synapse
Schmied L; Luu T; Søndergaard J; Meinke S; Mohammad D; Singh S; Mayer C; Casoni G; Chrobok M; Schlums H; Rota G; Truong H; Westerberg L; Guarda G; Alici E; Wagner A; Kadri N; Bryceson Y; Saeed M; Höglund P
Preprint: MEDRXIV. 2021
Loss-of-function mutation in IKZF2 leads to immunodeficiency with dysregulated germinal center reactions and reduction of MAIT cells
Hetemäki I; Kaustio M; Kinnunen M; Heikkilä N; Keskitalo S; Miettinen S; Sarkkinen J; Glumoff V; Andersson N; Kettunen K; Vanhanen R; Nurmi K; Eklund KK; Dunkel J; Mäyränpää M; Schlums H; Arstila TP; Kisand K; Bryceson YT; Peterson P; Otava U; Syrjänen J; Saarela J; Varjosalo M; Kekäläinen E
Preprint: BIORXIV. 2019
Dynamic changes in natural killer cell subset frequencies in the absence of cytomegalovirus infection
Gyurova IE; Schlums H; Sucharew H; Ambroggio L; Ochayon DE; Win HT; Bryceson YT; Bernstein DI; Waggoner SN
Corrigendum: FRONTIERS IN IMMUNOLOGY. 2019;10:350
Unperturbed Cytotoxic Lymphocyte Phenotype and Function in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients (vol 8, 723, 2017)
Theorell J; Bileviciute-Ljungar I; Tesi B; Schlums H; Johnsgaard MS; Asadi-Azarbaijani B; Strand EB; Bryceson YT
Thesis / dissertation: 2017
Human cytotoxic lymphocyte differentiation in health and disease
Schlums, Heinrich
Review: TRENDS IN IMMUNOLOGY. 2016;37(7):451-461
Epigenetic Regulation of Adaptive NK Cell Diversification
Tesi B; Schlums H; Cichocki F; Bryceson YT
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2016;395:63-94
Diversification and Functional Specialization of Human NK Cell Subsets
Cichocki F; Schlums H; Theorell J; Tesi B; Miller JS; Ljunggren H-G; Bryceson YT
Review: NANOPARTICLES FOR RATIONAL VACCINE DESIGN. 2016;395:225-243
The Past, Present, and Future of NK Cells in Hematopoietic Cell Transplantation and Adoptive Transfer
Cichocki F; Verneris MR; Cooley S; Bachanova V; Brunstein CG; Blazar BR; Wagner J; Schlums H; Bryceson YT; Weisdorf DJ; Miller JS
Letter: CLINICAL IMMUNOLOGY. 2015;159(1):58-62
A case of XMEN syndrome presented with severe auto-immune disorders mimicking autoimmune lymphoproliferative disease
Patiroglu T; Akar HH; Gilmour K; Unal E; Ozdemir MA; Bibi S; Burns S; Chiang SC; Schlums H; Bryceson YT; Karakukcu M
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2015;135(6):1638-1641
Hemophagocytic lymphohistiocytosis in 2 patients with underlying IFN-γ receptor deficiency
Tesi B; Sieni E; Neves C; Romano F; Cetica V; Cordeiro AI; Chiang S; Schlums H; Galli L; Avenali S; Tondo A; Canessa C; Henter J-I; Nordenskjold M; Hsu AP; Holland SM; Neves JE; Azzari C; Bryceson YT
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2013;162(3):415-418
Novel deep intronic and missense UNC13D mutations in familial haemophagocytic lymphohistiocytosis type 3
Entesarian M; Chiang SCC; Schlums H; Meeths M; Chan M-Y; Mya S-N; Soh S-Y; Nordenskjold M; Henter J-I; Bryceson YT
Review: JOURNAL OF INNATE IMMUNITY. 2011;3(3):216-226
Molecular Mechanisms of Natural Killer Cell Activation
Bryceson YT; Chiang SCC; Darmanin S; Fauriat C; Schlums H; Theorell J; Wood SM

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