Eva Kosek
Professor | Docent
E-postadress: eva.kosek@ki.se
Telefon: +46852482778
Besöksadress: Nobels väg 9, D3, 17165 Solna
Postadress: K8 Klinisk neurovetenskap, K8 Neuro Kosek, 171 77 Stockholm
Om mig
- Jag tog min medicinska examen (MD) vid Uppsala universitet 1986 och min doktorsexamen vid Karolinska Institutet, Stockholm 1996. Efter doktorsexamen specialiserade jag mig i rehabiliteringsmedicin (1998) och smärtlindring (2001) och har varit kliniskt verksam under den största delen av min karriär. Min forskning har jag bedrivit vid Karolinska Institutet, som docent sedan 2004 och som professor i klinisk smärtforskning sedan 2015. Sedan 2020 är jag även professor i klinisk smärtforskning vid Institutionen för kirurgiska vetenskaper vid Uppsala universitet, i kombination med en tjänst som överläkare vid Smärtcentrum på Akademiska sjukhuset i Uppsala. Jag kombinerar dessa tre positioner för att underlätta forskningssamarbete.
Forskningsbeskrivning
- Min forskning koncentrerar sig på patofysiologiska mekanismer vid långvarig smärta i rörelseapparaten, med särskild hänvisning till central smärtmodulering och neuroimmun interaktion. Min grupp studerar vanliga smärttillstånd som fibromyalgi, artros, reumatoid artrit och olika specifika kroniska smärttillstånd i ländryggen. Forskningen är hypotesdriven. Vi använder en mängd olika tekniker såsom genetik, analys av inflammatoriska ämnen i cerebrospinalvätska och blod, kvantitativ sensorisk testning och neuroimaging (funktionell magnetisk resonanstomografi, positronemissionstomografi). Jag har flera nationella och internationella forskningssamarbeten och deltar i translationella studier, för närvarande främst med fokus på autoreaktiva antikroppars roll vid fibromyalgi.
Som ordförande för International Association of Pain (IASP) Terminology Task Force var jag med och introducerade den nya smärtmekanistiska termen "nociplastisk smärta" avsedd för primära smärtsyndrom som kännetecknas av förändrad nociception (d.v.s. dysfunktionell smärtmodulering).
Artiklar
- Article: THE LANCET RHEUMATOLOGY. 2024;6(3):e178-e188
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2023;114:371-382
- Article: JOURNAL OF PAIN. 2023;24(9):1731-1743
- Article: PAIN. 2023;164(8):1828-1840
- Article: BIOMOLECULES. 2023;13(2):342
- Article: NATURE REVIEWS. RHEUMATOLOGY. 2023;19(1):44-60
- Article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2022;57:152101
- Article: BMJ OPEN. 2022;12(11):e066834
- Article: PAIN. 2022;163(10):1999-2013
- Article: MOLECULAR PSYCHIATRY. 2022;27(8):3452-3459
- Article: PAIN MEDICINE. 2022;23(6):1084-1094
- Article: PAIN. 2022;163(3):538-547
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2022;54(2):232-246
- Article: FRONTIERS IN NEUROSCIENCE. 2022;16:807773
- Article: FRONTIERS IN NEUROSCIENCE. 2022;16:942136
- Article: PLOS ONE. 2022;17(11):e0277427
- Article: EUROPEAN JOURNAL OF PAIN. 2021;25(8):1760-1769
- Article: JOURNAL OF CLINICAL MEDICINE. 2021;10(14):3138
- Article: JOURNAL OF CLINICAL INVESTIGATION. 2021;131(13):e144201
- Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2021;39(3):120-127
- Article: RHEUMATOLOGY. 2021;60(4):1724-1733
- Article: EUROPEAN JOURNAL OF PAIN. 2021;25(2):398-414
- Article: NATURE AND SCIENCE OF SLEEP. 2021;13:775-789
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2020;349:577391
- Article: SCIENTIFIC REPORTS. 2020;10(1):12508
- Article: MEDICINE & SCIENCE IN SPORTS & EXERCISE. 2020;52(7):1617-1628
- Article: JOURNAL OF ORAL REHABILITATION. 2020;47(2):150-157
- Article: MOLECULAR PAIN. 2020;16:1744806920927625
- Article: JOURNAL OF PAIN. 2019;20(11):1249-1266
- Article: JOURNAL OF REHABILITATION MEDICINE. 2019;51(10):779-787
- Article: EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING. 2019;46(11):2329-2338
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2019;81:272-279
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2019;334:577000
- Article: NEUROIMAGE. 2019;188:102-110
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(3):E658-658
- Article: JOURNAL OF PROTEOMICS. 2019;190:67-76
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2019;75:60-71
- Article: JOURNAL OF ORAL AND FACIAL PAIN AND HEADACHE. 2019;33(1):14-24
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2019;75:72-83
- Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):262
- Article: JOURNAL OF PAIN. 2018;19(11):1318-1328
- Article: JOURNAL OF IMMUNOLOGY. 2018;201(7):1918-1927
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2018;321:49-60
- Article: CLINICAL PHYSIOLOGY AND FUNCTIONAL IMAGING. 2018;38(3):508-516
- Article: BMC MUSCULOSKELETAL DISORDERS. 2018;19(1):121
- Article: ARTHRITIS RESEARCH & THERAPY. 2018;20(1):48
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2018;68:146-157
- Article: MEDIATORS OF INFLAMMATION. 2018;2018:3985154-14
- Article: JOURNAL OF REHABILITATION MEDICINE. 2017;49(9):744-750
- Article: JOURNAL OF PAIN. 2017;18(7):835-843
- Article: BMC MUSCULOSKELETAL DISORDERS. 2017;18(1):106
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2016;58:218-227
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2016;57:38-46
- Article: ARTHRITIS RESEARCH & THERAPY. 2016;18:176
- Article: ARTHRITIS RESEARCH & THERAPY. 2016;18(1):137
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2016;54:149-157
- Article: EUROPEAN JOURNAL OF PAIN. 2016;20(3):472-482
- Article: FRONTIERS IN HUMAN NEUROSCIENCE. 2016;10:107
- Article: SCIENTIFIC REPORTS. 2015;5:15925
- Article: ARTHRITIS RESEARCH & THERAPY. 2015;17(1):161
- Article: BRAIN, BEHAVIOR, AND IMMUNITY. 2015;46:35-43
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2015;280:49-55
- Article: NEUROIMAGE: CLINICAL. 2015;9:134-139
- Article: JOURNAL OF PAIN. 2014;15(12):1328-1337
- Article: BRAIN CONNECTIVITY. 2014;4(8):587-594
- Article: PAIN. 2014;155(10):2171-2179
- Article: JOURNAL OF REHABILITATION MEDICINE. 2014;46(8):773-780
- Article: ARTHRITIS & RHEUMATOLOGY. 2013;65(12):3293-3303
- Article: OSTEOARTHRITIS AND CARTILAGE. 2013;21(9):1299-1307
- Article: BMC MUSCULOSKELETAL DISORDERS. 2013;14:232
- Article: DISABILITY AND REHABILITATION. 2013;35(16):1350-1356
- Article: SCANDINAVIAN JOURNAL OF PAIN. 2013;4(2):65-74
- Article: EUROPEAN JOURNAL OF PAIN. 2013;17(4):599-611
- Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(31):12728-12733
- Article: SCANDINAVIAN JOURNAL OF PAIN. 2012;3(3):113-115
- Article: PAIN. 2012;153(7):1495-1503
- Article: MOLECULAR PAIN. 2012;8:1744-8069-8-32
- Article: JOURNAL OF NEUROIMMUNOLOGY. 2012;242(1-2):33-38
- Article: PLOS ONE. 2012;7(8):e43221
- Article: PLOS ONE. 2011;6(3):e18252
- Article: PLOS ONE. 2011;6(3):e17752
- Article: PLOS ONE. 2011;6(11):e27075
- Article: ARTHRITIS & RHEUMATOLOGY. 2010;62(11):3488-3495
- Article: PAIN. 2010;151(1):77-86
- Article: JOURNAL OF REHABILITATION MEDICINE. 2010;42(8):765-772
- Article: PAIN. 2009;144(1-2):95-100
- Article: PLOS ONE. 2009;4(6):e6016
- Article: EUROPEAN JOURNAL OF PAIN. 2008;12(5):650-660
- Article: ANNALS OF THE RHEUMATIC DISEASES. 2008;67(4):536-541
- Article: PAIN. 2007;127(3):263-269
- Article: EUROPEAN JOURNAL OF PAIN. 2007;11(1):39-47
- Article: EUROPEAN JOURNAL OF PAIN. 2006;10(2):137-144
- Article: PAIN. 2003;105(1-2):125-131
- Article: LAKARTIDNINGEN. 2003;100(18):1600-1602
- Article: EUROPEAN JOURNAL OF PAIN. 2003;7(3):267-276
- Article: EUROPEAN JOURNAL OF PAIN. 2003;7(3):251-258
- Article: PAIN. 2002;96(1-2):177-187
- Article: EUROPEAN JOURNAL OF PAIN. 2002;6(6):413-425
- Article: EUROPEAN JOURNAL OF PAIN. 2002;6(2):161-176
- Article: EUROPEAN JOURNAL OF PAIN. 2002;6(2):149-159
- Article: EUROPEAN JOURNAL OF PAIN. 2000;4(3):229-238
- Article: EUROPEAN JOURNAL OF PAIN. 2000;4(1):73-82
- Article: EUROPEAN JOURNAL OF PAIN. 2000;4(1):57-71
- Article: JOURNAL OF REHABILITATION MEDICINE. 1999;31(2):89-93
- Article: PAIN. 1996;68(2-3):375-383
- Article: PAIN. 1995;63(3):335-339
- Article: PAIN. 1995;61(3):481-486
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Alla övriga publikationer
- Review: NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS. 2023;151:105235
- Letter: NATURE REVIEWS. RHEUMATOLOGY. 2023;19(5):322-323
- Letter: NATURE REVIEWS. RHEUMATOLOGY. 2023;19(5):319-320
- Letter: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2023;59:152162
- Letter: PAIN. 2023;164(2):e116-E117
- Review: PAIN REPORTS. 2023;8(1):e1061
- Letter: PAIN. 2022;163(8):e964-e965
- Editorial comment: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(6):1073-1075
- Letter: PAIN. 2022;163(4):e607-e608
- Review: PAIN. 2021;162(11):2629-2634
- Letter: THE LANCET RHEUMATOLOGY. 2021;3(8):E548-E549
- Review: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2021;39(3):186-193
- Review: THE LANCET RHEUMATOLOGY. 2021;3(5):E383-E392
- Letter: PAIN. 2019;160(7):1683-1685
- Review: PAIN. 2019;160(1):53-59
- Review: PAIN. 2019;160(1):28-37
- Letter: PAIN. 2018;159(6):1177-1178
- Letter: PAIN. 2017;158(7):1396-1397
- Review: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(2):318-328
- Letter: PAIN. 2017;158(1):180
- Letter: PAIN. 2016;157(12):2876-2877
- Review: PAIN. 2016;157(7):1382-1386
- Review: PAIN. 2015;156(6):1003-1007
- Corrigendum: PAIN. 2012;153(9):1981
- Review: PAIN PHYSICIAN. 2012;15(3):ES205-ES213
- Review: LAKARTIDNINGEN. 2008;105(35):2328-2332
- Meeting abstract: EUROPEAN NEUROPSYCHOPHARMACOLOGY. 2008;18:S580
- Thesis / dissertation: 1996
- Addendum: PAIN. 1996;64(3):603
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Anställningar
- Professor, Klinisk neurovetenskap, Karolinska Institutet, 2019-
Examina och utbildning
- Docent, smärtforskning, Karolinska Institutet, 2004