Emma Wincent

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Emma Wincent är forskare inom molekylär toxikologi vid Karolinska Institutet (KI), Institutet för miljömedicin, enheten för systemtoxikologi.
Hon tog sin M.Sc. examen i Toxikologi 2002 vid KI och en doktorsexamen i Toxikologi 2009 vid Stockholms universitet. 2009 påbörjade hon en Post Doc tjänst i miljömedicin i professor Agneta Rannugs grupp vid KI, och rekryterades 2015 till "Swedish Toxicology Sciences Research Center" (SWETOX) för att leda en forskningsgren inom toxikokinetik. Hon återvände till KI, till Institutet för Miljömedicin (IMM), 2018/2019 och har sedan dess
bedrivit sin forskning där inom områden relaterade till toxikokinetik och molekylär toxikologi. Emma är också kursledare och frekvent lärare vid det globala Magisterprogrammet i Toxikologi vid Karolinska Institutet.

*/Ytterligare beskrivning av Dr. Wincents forskningsprofil finns på den engelska sidan./*

Artiklar

Journal article: PHARMACOLOGICAL RESEARCH. 2023;194:106848
Manuka honey activates the aryl hydrocarbon receptor: Implications for skin inflammation
Alangari AA; Ashoori MD; Alwan W; Dawe HR; Stockinger B; Barker JN; Wincent E; Di Meglio P
Article: TOXICOLOGY IN VITRO. 2023;89:105588
PBTK modeled perfluoroalkyl acid kinetics in zebrafish eleutheroembryos suggests impacts on bioconcentrations by chorion porosity dynamics
Billat P-A; Vogs C; Blassiau C; Brochot C; Wincent E; Brion F; Beaudouin R
Article: ENVIRONMENTAL POLLUTION. 2023;316(Pt 1):120510
Non-additive mixture effects of benzo[a]pyrene and pesticides in vitro and in vivo: Role of AhR signaling*
Endirlik BU; Wincent E; Dreij K
Journal article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):s238
337 Multi-level dysregulation of the AHR/CYP1A1 axis in psoriasis
Ashoori M; Hardman-Smart J; Dawe H; Tosi I; vincent E; Barker J; Smith C; Di Meglio P
Article: AQUATIC TOXICOLOGY. 2022;252:106311
Kinetics and toxicity of an environmentally relevant mixture of halogenated organic compounds in zebrafish embryo.
Lindqvist D; Wincent E
Article: ECOTOXICOLOGY. 2022;31(9):1382-1389
Endogenous AhR agonist FICZ accumulates in rainbow trout (Oncorhynchus mykiss) alevins exposed to a mixture of two PAHs, retene and fluoranthene
Eriksson ANM; Rigaud C; Wincent E; Pakkanen H; Salonen P; Vehniainen E-R
Article: AQUATIC TOXICOLOGY. 2022;244:106083
Exposure to retene, fluoranthene, and their binary mixture causes distinct transcriptomic and apical outcomes in rainbow trout (Oncorhynchus mykiss) yolk sac alevins
Eriksson ANM; Rigaud C; Krasnov A; Wincent E; Vehniainen E-R
Article: DISEASE MODELS & MECHANISMS. 2021;14(12):dmm049104
Perfluorooctanesulfonic acid modulates barrier function and systemic T-cell homeostasis during intestinal inflammation
Diaz OE; Sorini C; Morales RA; Luo X; Frede A; Krais AM; Chavez MN; Wincent E; Das S; Villablanca EJ
Article: SCIENCE OF THE TOTAL ENVIRONMENT. 2020;745:141031
Retene, pyrene and phenanthrene cause distinct molecular-level changes in the cardiac tissue of rainbow trout (Oncorhynchus mykiss) larvae, part 1-Transcriptomics
Rigaud C; Eriksson A; Krasnov A; Wincent E; Pakkanen H; Lehtivuori H; Ihalainen J; Vehniainen E-R
Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2019;53(7):3898-3907
Toxicokinetics of Perfluorinated Alkyl Acids Influences Their Toxic Potency in the Zebrafish Embryo (Danio rerio)
Vogs C; Johanson G; Naslund M; Wulff S; Sjodin M; Hellstrandh M; Lindberg J; Wincent E
Article: BIOCHEMICAL PHARMACOLOGY. 2018;151:47-58
Cytochrome P4501-inhibiting chemicals amplify aryl hydrocarbon receptor activation and IL-22 production in T helper 17 cells
Schiering C; Vonk A; Das S; Stockinger B; Wincent E
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2018;281:1-10
Cellular accumulation and lipid binding of perfluorinated alkylated substances (PFASs) - A comparison with lysosomotropic drugs
Garcia DS; Sjodin M; Hellstrandh M; Norinder U; Nikiforova V; Lindberg J; Wincent E; Bergman A; Cotgreave I; Kos VM
Article: NATURE. 2017;542(7640):242-245
Feedback control of AHR signalling regulates intestinal immunity
Schiering C; Wincent E; Metidji A; Iseppon A; Li Y; Potocnik AJ; Omenetti S; Henderson CJ; Wolf CR; Neberts DW; Stockinger B
Article: BIOCHEMICAL PHARMACOLOGY. 2016;110:117-129
Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner
Wincent E; Kubota A; Timme-Laragy A; Jonsson ME; Hahn ME; Stegeman JJ
Article: TOXICOLOGY RESEARCH. 2016;5(3):788-799
Induction and inhibition of human cytochrome P4501 by oxygenated polycyclic aromatic hydrocarbons
Wincent E; Le Bihanic F; Dreij K
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2016;29(1):75-86
Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ
Smirnova A; Wincent E; Bergander LV; Alsberg T; Bergman J; Rannug A; Rannug U
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;284(2):163-179
Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions
Wincent E; Stegeman JJ; Jonsson ME
Article: ENVIRONMENTAL SCIENCE AND TECHNOLOGY. 2015;49(6):3869-3877
Aryl Hydrocarbon Receptor Activation and Developmental Toxicity in Zebrafish in Response to Soil Extracts Containing Unsubstituted and Oxygenated PAHs
Wincent E; Jonsson ME; Bottai M; Lundstedt S; Dreij K
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2012;25(9):1878-1884
Quercetin, Resveratrol, and Curcumin Are Indirect Activators of the Aryl Hydrocarbon Receptor (AHR)
Mohammadi-Bardbori A; Bengtsson J; Rannug U; Rannug A; Wincent E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(12):4479-4484
Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor
Wincent E; Bengtsson J; Bardbori AM; Alsberg T; Luecke S; Rannug U; Rannug A
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2010;184(3):466-473
Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor κB
Luecke S; Wincent E; Backlund M; Rannug U; Rannug A
Article: BIOORGANIC AND MEDICINAL CHEMISTRY. 2009;17(4):1648-1653
Synthesis and biological evaluation of fused thio- and selenopyrans as new indolocarbazole analogues with aryl hydrocarbon receptor affinity
Wincent E; Shirani H; Bergman J; Rannug U; Janosik T
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(5):2690-2696
The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans
Wincent E; Amini N; Luecke S; Glatt H; Bergman J; Crescenzi C; Rannug A; Rannug U
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2004;149(2-3):151-164
Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole
Bergander L; Wincent E; Rannug A; Foroozesh M; Alworth W; Rannug U
Visa fler

Alla övriga publikationer

Conference publication: TOXICOLOGY LETTERS. 2022;368:S207-S208
Estimation of chemosensory irritation potency by using a TRPV1 channel-expressing human neuroblastoma cell model
Hinojosa M; Johanson G; Vincent E; Forsby A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(12):S238
Induced pluripotent stem cell-derived macrophages in an inflammatory skin disease model to study granuloma formation
Ashoori M; Hardman-Smart J; Dawe H; Tosi I; Vincent E; Barker J; Smith C; Di Meglio P
Review: NATURE REVIEWS GASTROENTEROLOGY AND HEPATOLOGY. 2021;18(8):559-570
AHR in the intestinal microenvironment: safeguarding barrier function
Stockinger B; Shah K; Wincent E
Corrigendum: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2015;288(2):280
Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions (vol 284, pg 163, 2015)
Wincent E; Stegeman JJ; Jonsson ME
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S117-S118
Ketoconazole activates the AHR by inhibiting CYP1A1 dependent metabolism of FICZ
Bengtsson J; Wincent E; Rannug A; Rannug U
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S14
Biological effects of the proposed endogenous AHR ligand FICZ
Rannug A; Wincent E; Bardbori AM; Rannug U
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S14
Formation and background levels of the endogenous AHR ligand FICZ in vitro and in vivo
Rannug U; Smirnova A; Alsberg T; Wincent E; Rannug A
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S143-S144
Metals induce cytochrome P4501A1 through inhibition of metabolic degradation of FICZ
Bardbori AM; Wincent E; Rannug U; Rannug A
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S117
Cytochrome P4501 inhibition as a novel mechanism for activation of the Ah receptor
Wincent E; Bengtsson J; Bardbori AM; Alsberg T; Rannug U; Rannug A

Forskningsbidrag

NEMESIS: Novel Effect biomarkers for MEtabolic disruptorS: evidence on health Impacts to answer science and policy needS
1 January 2024 - 31 December 2028
Unraveling underlying modes of action of early-life metal mixture exposure on child growth: integrating epidemiological and experimental evidence
Swedish Research Council
1 January 2023 - 31 December 2025
INQUIRE: IMPROVING INDOOR AIR QUALITY AND HEALTH: IDENTIFICATION OF CHEMICAL AND BIOLOGICAL DETERMINANTS, THEIR SOURCES, AND STRATEGIES TO PROMOTE HEALTHIER HOMES IN EUROPE
EU-HORIZON Environment and Health
1 September 2022 - 31 August 2027
The role of host microbiota in chemically induced metabolic disruption
Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
1 January 2022 - 31 December 2024
Chemical impact on tissue repair and regeneration – interrogating beneficial vs. toxicological functions of aryl hydrocarbon receptor signalling on tissue homeostasis
Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
1 January 2022 - 31 December 2024
Elucidating basis for detrimental vs.beneficial functions of the aryl hydrocarbon receptor in intestinal stem cell differentiation
Swedish Research Council
1 January 2021 - 31 December 2024
A novel mechanism-based approach for assessment of developmental toxicity of endocrine disruptors
Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
1 January 2021 - 31 December 2024
Novel in vitro approaches to quantify chemosensory irritation as basis for exposure limits
Swedish Research Council
1 December 2020 - 31 December 2023
Addressing the intestinal immunotoxic effect of environmental pollutants: perfluorinated compounds
Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
1 January 2017 - 31 December 2019
Toxicokinetic modeling of internal dose in zebrafish (Danio rerio) embryos
Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning
1 January 2015 - 31 December 2018
The consequences of a dysfunctional CYP1/AHR auto-regulatory feedback loop in AHR mediated regulation of development and immune responses
Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning
1 January 2012 - 31 December 2015
Travel contribution: Society for Toxicology's Annual Meeting in Washington, USA, 6-10 March, 2011 and participation in a mini-symposium at Woods ...
Swedish Research Council for Health Working Life and Welfare
1 February 2011 - 31 March 2011

Om mig

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

Kalenderhändelser från KI