Emma Wincent

Emma Wincent

Senior Forskare | Docent
E-postadress: emma.wincent@ki.se
Besöksadress: Nobels väg 13, 17177 Stockholm
Postadress: C6 Institutet för miljömedicin, C6 Systemtoxikologi Vincent, 171 77 Stockholm

Om mig

  • Emma Wincent är forskare inom molekylär toxikologi vid Karolinska Institutet (KI), Institutet för miljömedicin, enheten för systemtoxikologi.
    Hon tog sin M.Sc. examen i Toxikologi 2002 vid KI och en doktorsexamen i Toxikologi 2009 vid Stockholms universitet. 2009 påbörjade hon en Post Doc tjänst i miljömedicin i professor Agneta Rannugs grupp vid KI, och rekryterades 2015 till "Swedish Toxicology Sciences Research Center" (SWETOX) för att leda en forskningsgren inom toxikokinetik. Hon återvände till KI, till Institutet för Miljömedicin (IMM), 2018/2019 och har sedan dess
    bedrivit sin forskning där inom områden relaterade till toxikokinetik och molekylär toxikologi. Emma är också kursledare och frekvent lärare vid det globala Magisterprogrammet i Toxikologi vid Karolinska Institutet.

    */Ytterligare beskrivning av Dr. Wincents forskningsprofil finns på den engelska sidan./*

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2023 - 31 December 2025
    Emerging epidemiological data suggest that early-life exposure to metals and metal mixtures is associated with altered fetal and child growth, but underlying modes of action (MoAs) are largely unknown. The overall purpose of this 4-year project is to delineate underlying mechanisms of metal mixture toxicity by targeted and non-targeted approaches, combining data from a Swedish birth cohort (n=600) with an established developmental toxicity model. Metal mixtures (cadmium, lead, methylmercury, fluoride) have been measured during pregnancy, and in the children at 4 months and 4 years using well-established exposure biomarkers. These measurements will be related to several growth/bone-related hormones and bone remodeling markers at 4 years using statistical models designed for mixtures [Weighted Quantile Sum regression (WQS) and Bayesian Kernel Machine Regression (BKMR)]. In parallel, we will study morphological, functional and molecular effects of the metal’s mixtures on zebrafish development and growth, combining a targeted (morphometrics, hormone levels) and untargeted approach (RNAseq, metabolomics). Altogether, this will increase our understanding of MoAs for metal-induced adverse effects on child growth and critical windows of exposure, enable us to identify novel molecular markers for key events in these MoAs, and thereby strengthen causality in epidemiological data, all which can serve as tools for future health risk monitoring and preventive actions.
  • INQUIRE: IMPROVING INDOOR AIR QUALITY AND HEALTH: IDENTIFICATION OF CHEMICAL AND BIOLOGICAL DETERMINANTS, THEIR SOURCES, AND STRATEGIES TO PROMOTE HEALTHIER HOMES IN EUROPE
    EU-HORIZON Environment and Health
    1 September 2022 - 31 August 2027
  • Horison Europe
    1 September 2022 - 31 August 2027
    INQUIRE aims to protect citizen health by providing knowledge, tools, and measures to substantially improve indoor air quality (IAQ). We will conduct research and evaluate innovative actions to reduce hazardous chemical and biological determinants in homes, positively impacting the health of residents. INQUIRE will focus particularly on infants and young children (<5 years old) as highly sensitive groups that spend a substantial time in the home environment. INQUIRE will comprehensively advance our understanding of the determinants of IAQ in homes by implementing innovative, low-cost, non-invasive sampling strategies (sensors, indoor/outdoor passive sampling, urine biomonitoring) to characterize determinants of household IAQ and their importance to human exposure. To capture the breath of IAQ determinants across Europe, the study will monitor for one month over 200 homes distributed across 8 countries, covering a gradient of conditions in each country. Tiered high-resolution chemical and biological screening techniques and wide-scope holistic characterisation of hazards will provide a comprehensive assessment of the determinants of IAQ. Multifaceted data analysis techniques (including machine learning, exposure modelling, geospatial analysis), will link chemical, biological and toxicity profiles with drivers of IAQ to identify sources and prioritize pollutants. Source identification will feed directly into the testing of both novel technologies and readily deployable strategies to improve IAQ, resulting in evidence-based recommendations and a draft of policy strategy for developing IAQ standards. INQUIREs Open Science approach and generated FAIR data on hazardous determinants, their effects, risk factors and sources will endorse continuous exploitation of results. Open dissemination of generated knowledge will raise citizen awareness while exploitation by industry and policy makers will endorse a transition towards homes with zero pollution. The project INQUIRE is part of the European cluster on indoor air quality and health, IDEAL.
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2022 - 31 December 2024
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2022 - 31 December 2024
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2021 - 31 December 2024
  • A novel mechanism-based approach for assessment of developmental toxicity of endocrine disruptors
    FORMAS
    1 January 2021 - 31 December 2024
  • Swedish Research Council
    1 December 2020 - 31 December 2023
  • Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
    1 January 2017 - 31 December 2019
  • Toxicokinetic modeling of internal dose in zebrafish (Danio rerio) embryos
    Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning
    1 January 2015 - 31 December 2018
  • The consequences of a dysfunctional CYP1/AHR auto-regulatory feedback loop in AHR mediated regulation of development and immune responses
    Swedish Research Council for Environment, Agricultural Sciences and Spatial Planning
    1 January 2012 - 31 December 2015
  • Travel contribution: Society for Toxicology's Annual Meeting in Washington, USA, 6-10 March, 2011 and participation in a mini-symposium at Woods ...
    Swedish Research Council for Health Working Life and Welfare
    1 February 2011 - 31 March 2011

Anställningar

  • Senior Forskare, Institutet för miljömedicin, Karolinska Institutet, 2022-

Examina och utbildning

  • Docent, Toxikologi, Karolinska Institutet, 2021
  • Medicine Magisterexamen, Karolinska Institutet, 2005

Nyheter från KI

Kalenderhändelser från KI