Christer Betsholtz

Om mig
Publikationer
CV
Populärvetenskap och samverkan

Om mig

Christer Betsholtz blev professor i vaskulär biologi vid Karolinska Institutet 2004.

Artiklar

Journal article: NEURON. 2024;112(19):3223-3225
Insights into mechanisms and therapeutic avenues for primary familial brain calcification.
Betsholtz C
Journal article: NATURE COMMUNICATIONS. 2024;15(1):7643
Adipose stem cells are sexually dimorphic cells with dual roles as preadipocytes and resident fibroblasts
Uhrbom M; Muhl L; Genove G; Liu J; Palmgren H; Alexandersson I; Karlsson F; Zhou A-X; Lunnerdal S; Gustafsson S; Buyandelger B; Petkevicius K; Ahlstedt I; Karlsson D; Aasehaug L; He L; Jeansson M; Betsholtz C; Peng X-R
Article: ANGIOGENESIS. 2019;22(4):491-505
Adgrf5 contributes to patterning of the endothelial deep layer in retina.
Niaudet C; Petkova M; Jung B; Lu S; Laviña B; Offermanns S; Brakebusch C; Betsholtz C
Article: ELIFE. 2019;8:e47178
GPIHBP1 expression in gliomas promotes utilization of lipoprotein-derived nutrients
Hu X; Matsumoto K; Jung RS; Weston TA; Heizer PJ; He C; Sandoval NP; Allan CM; Tu Y; Vinters HV; Liau LM; Ellison RM; Morales JE; Baufeld LJ; Bayley NA; He L; Betsholtz C; Beigneux API; Nathanson DA; Gerhardt H; Young SG; Fong LG; Jian H
Article: CELL REPORTS. 2019;27(4):1073-1089.e5
Powerful Homeostatic Control of Oligodendroglial Lineage by PDGFRα in Adult Brain
Thanh CD; Ishii Y; Van DN; Yamamoto S; Hamashima T; Okuno N; Quang LN; Sang Y; Ohkawa N; Saitoh Y; Shehata M; Takakura N; Fujimori T; Inokuchi K; Mori H; Andrae J; Betsholtz C; Sasahara M
Article: CIRCULATION RESEARCH. 2019;124(8):1240-1252
CDC42 Deletion Elicits Cerebral Vascular Malformations via Increased MEKK3-Dependent KLF4 Expression
Castro M; Lavina B; Ando K; Alvarez-Aznar A; Abu Taha A; Brakebusch C; Dejana E; Betsholtz C; Gaengel K
Article: CELL REPORTS. 2019;26(11):2955-2969.e3
PDGF-B Is Required for Development of the Glymphatic System
Munk AS; Wang W; Bechet NB; Eltanahy AM; Cheng AX; Sigurdsson B; Benraiss A; Mae MA; Kress BT; Kelley DH; Betsholtz C; Mollgard K; Meissner A; Nedergaard M; Lundgaard I
Article: DEVELOPMENT. 2019;146(2):dev165589
Peri-arterial specification of vascular mural cells from naive mesenchyme requires Notch signaling
Ando K; Wang W; Peng D; Chiba A; Lagendijk AK; Barske L; Crump JG; Stainier DYR; Lendahl U; Koltowska K; Hogan BM; Fukuhara S; Mochizuki N; Betsholtz C
Article: SCIENTIFIC REPORTS. 2019;9(1):203
Claudin-3-deficient C57BL/6J mice display intact brain barriers
Dias MC; Coisne C; Lazarevic I; Baden P; Hata M; Iwamoto N; Francisco DMF; Vanlandewijck M; He L; Baier FA; Stroka D; Bruggmann R; Lyck R; Enzmann G; Deutsch U; Betsholtz C; Furuse M; Tsukita S; Engelhardt B
Article: VASCULAR PHARMACOLOGY. 2019;112:8-16
Sprouting and anastomosis in the Drosophila trachea and the vertebrate vasculature: Similarities and differences in cell behaviour
Kotini MP; Mae MA; Belting H-G; Betsholtz C; Affolter M
Article: SCIENTIFIC REPORTS. 2018;8(1):17462
Prolonged systemic hyperglycemia does not cause pericyte loss and permeability at the mouse blood-brain barrier
Mae MA; Li T; Bertuzzi G; Raschperger E; Vanlandewijck M; He L; Nahar K; Dalheim A; Hofmann JJ; Lavina B; Keller A; Betsholtz C; Genove G
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 2018;215(11):2760-2777
Multiple roles of lymphatic vessels in peripheral lymph node development
Bovay E; Sabine A; Prat-Luri B; Kim S; Son K; Willrodt A-H; Olsson C; Halin C; Kiefer F; Betsholtz C; Li Jeon N; Luther SA; Petrova TV
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2018;124:182-187
Rate of small-molecular drug transport across the blood-brain barrier in a pericyte-deficient state.
Mihajlica N; Betsholtz C; Hammarlund-Udenaes M
Article: EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2018;122:77-84
Pharmacokinetics of pericyte involvement in small-molecular drug transport across the blood-brain barrier.
Mihajlica N; Betsholtz C; Hammarlund-Udenaes M
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2018;33(9):1514-1525
Inverse correlation between vascular endothelial growth factor back-filtration and capillary filtration pressures.
Kuppe C; Rohlfs W; Grepl M; Schulte K; Veron D; Elger M; Sanden SK; Saritas T; Andrae J; Betsholtz C; Trautwein C; Hausmann R; Quaggin S; Bachmann S; Kriz W; Tufro A; Floege J; Moeller MJ
Article: SCIENTIFIC DATA. 2018;5:180160
Single-cell RNA sequencing of mouse brain and lung vascular and vessel-associated cell types
He L; Vanlandewijck M; Mae MA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Lavina B; Gouveia L; Sun Y; Raschperger E; Segerstolpe A; Liu J; Gustafsson S; Rasanen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Article: NATURE COMMUNICATIONS. 2018;9(1):2746
Intravital imaging-based analysis tools for vessel identification and assessment of concurrent dynamic vascular events.
Honkura N; Richards M; Laviña B; Sáinz-Jaspeado M; Betsholtz C; Claesson-Welsh L
Article: DEVELOPMENT. 2018;145(13):dev161182
Defective endothelial cell migration in the absence of Cdc42 leads to capillary-venous malformations
Lavina B; Castro M; Niaudet C; Cruys B; Alvarez-Aznar A; Carmeliet P; Bentley K; Brakebusch C; Betsholtz C; Gaengel K
Article: DEVELOPMENT. 2018;145(7):dev161976
PDGF-A signaling is required for secondary alveolar septation and controls epithelial proliferation in the developing lung
Gouveia L; Betsholtz C; Andrae J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - LUNG CELLULAR AND MOLECULAR PHYSIOLOGY. 2018;314(4):L593-L605
Extracellular retention of PDGF-B directs vascular remodeling in mouse hypoxia-induced pulmonary hypertension
Tannenberg P; Chang Y-T; Muhl L; Lavina B; Gladh H; Genove G; Betsholtz C; Folestad E; Tran-Lundmark K
Article: JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM. 2018;38(3):456-468
Visualization of vascular mural cells in developing brain using genetically labeled transgenic reporter mice
Jung B; Arnold TD; Raschperger E; Gaengel K; Betsholtz C
Article: NATURE. 2018;554(7693):475-480
A molecular atlas of cell types and zonation in the brain vasculature
Vanlandewijck M; He L; Mae MAA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Lavina B; Gouveia L; Sun Y; Raschperger E; Rasanen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Article: METHODS IN MOLECULAR BIOLOGY. 2018;1846:309-324
Single-Cell mRNA Sequencing of the Mouse Brain Vasculature.
Vanlandewijck M; Betsholtz C
Article: PEERJ. 2018;6:e4466
Global analysis of A-to-I RNA editing reveals association with common disease variants
Franzen O; Ermel R; Sukhavasi K; Jain R; Jain A; Betsholtz C; Giannarelli C; Kovacic JC; Ruusalepp A; Skogsberg J; Hao K; Schadt EE; Bjorkegren JLM
Article: PLOS ONE. 2018;13(1):e0189433
Angiopoietin-1 deficiency increases renal capillary rarefaction and tubulointerstitial fibrosis in mice
Loganathan K; Said ES; Winterrowd E; Orebrand M; He L; Vanlandewijck M; Betsholtz C; Quaggin SE; Jeansson M
Article: DEVELOPMENT. 2017;144(19):3590-3601
Smooth muscle cell recruitment to lymphatic vessels requires PDGFB and impacts vessel size but not identity
Wang Y; Jin Y; Mae MA; Zhang Y; Ortsater H; Betsholtz C; Makinen T; Jakobsson L
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2017;28(10):2961-2972
Transcriptomic and Proteomic Profiling Provides Insight into Mesangial Cell Function in IgA Nephropathy
Liu P; Lassen E; Nair V; Berthier CC; Suguro M; Sihlbom C; Kretzler M; Betsholtz C; Haraldsson B; Ju W; Ebefors K; Nystrom J
Article: CELL REPORTS. 2017;20(8):1755-1764
Pericytes Stimulate Oligodendrocyte Progenitor Cell Differentiation during CNS Remyelination
De La Fuente AG; Lange S; Silva ME; Gonzalez GA; Tempfer H; van Wijngaarden P; Zhao C; Di Canio L; Trost A; Bieler L; Zaunmair P; Rotheneichner P; O'Sullivan A; Couillard-Despres S; Errea O; Mae MA; Andrae J; He L; Keller A; Batiz LF; Betsholtz C; Aigner L; Franklin RJM; Rivera FJ
Article: NATURE CELL BIOLOGY. 2017;19(6):639-652
Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling
Jin Y; Muhl L; Burmakin M; Wang Y; Duchez A-C; Betsholtz C; Arthur HM; Jakobsson L
Article: PHYSIOLOGICAL REPORTS. 2017;5(6):e13092
Expression analysis of platelet-derived growth factor receptor alpha and its ligands in the developing mouse lung.
Gouveia L; Betsholtz C; Andrae J
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2017;69(7):823-836
Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease
Webb TR; Erdmann J; Stirrups KE; Stitziel NO; Masca NGD; Jansen H; Kanoni S; Nelson CP; Ferrario PG; Koenig IR; Eicher JD; Johnson AD; Hamby SE; Betsholtz C; Ruusalepp A; Franzen O; Schadt EE; Bjoerkegren JLM; Weeke PE; Auer PL; Schick UM; Lu Y; Zhang H; Dube M-P; Goel A; Farrall M; Peloso GM; Won H-H; Do R; van Iperen E; Kruppa J; Mahajan A; Scott RA; Willenborg C; Braund PS; van Capelleveen JC; Doney ASF; Donnelly LA; Asselta R; Merlini PA; Duga S; Marziliano N; Denny JC; Shaffer C; El-Mokhtari NE; Franke A; Heilmann S; Hengstenberg C; Hoffmann P; Holmen OL; Hveem K; Jansson J-H; Joeckel K-H; Kessler T; Kriebel J; Laugwitz KL; Marouli E; Martinelli N; McCarthy MI; Van Zuydam NR; Meisinger C; Esko T; Mihailov E; Escher SA; Alver M; Moebus S; Morris AD; Virtamo J; Nikpay M; Olivieri O; Provost S; AlQarawi A; Robertson NR; Akinsansya KO; Reilly DF; Vogt TF; Yin W; Asselbergs FW; Kooperberg C; Jackson RD; Stahl E; Mueller-Nurasyid M; Strauch K; Varga TV; Waldenberger M; Zeng L; Chowdhury R; Salomaa V; Ford I; Jukema JW; Amouyel P; Kontto J; Nordestgaard BG; Ferrieres J; Saleheen D; Sattar N; Surendran P; Wagner A; Young R; Howson JMM; Butterworth AS; Danesh J; Ardissino D; Bottinger EP; Erbel R; Franks PW; Girelli D; Hall AS; Hovingh GK; Kastrati A; Lieb W; Meitinger T; Kraus WE; Shah SH; McPherson R; Orho-Melander M; Melander O; Metspalu A; Palmer CNA; Peters A; Rader DJ; Reilly MP; Loos RJF; Reiner AP; Roden DM; Tardif J-C; Thompson JR; Wareham NJ; Watkins H; Willer CJ; Samani NJ; Schunkert H; Deloukas P; Kathiresan S
Article: CIRCULATION RESEARCH. 2017;120(2):341-353
Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk Loci
Jones GT; Tromp G; Kuivaniemi H; Gretarsdottir S; Baas AF; Giusti B; Strauss E; van't Hof FNG; Webb TR; Erdman R; Ritchie MD; Elmore JR; Verma A; Pendergrass S; Kullo IJ; Zy ZY; Peissig PL; Gottesman O; Verma SS; Malinowski J; Rasmussen-Torvik LJ; Borthwick KM; Smelser DT; Crosslin DR; de Andrade M; Ryer EJ; McCarty CA; Bottinger EP; Pacheco JA; Crawford DC; Carrell DS; Gerhard GS; Franklin DP; Carey DJ; Phillips VL; Williams MJA; Wei W; Blair R; Hill AA; Vasudevan TM; Lewis DR; Thomson IA; Krysa J; Hill GB; Roake J; Merriman TR; Oszkinis G; Galora S; Saracini C; Abbate R; Pulli R; Pratesi C; Saratzis A; Verissimo AR; Bumpstead S; Badger SA; Clough RE; Cockerill G; Hafez H; Scott DJA; Futers TS; Romaine SPR; Bridge K; Griffin KJ; Bailey MA; Smith A; Thompson MM; van Bockxmeer FM; Matthiasson SE; Thorleifsson G; Thorsteinsdottir U; Blankensteijn JD; Teijink JAW; Wijmenga C; de Graaf J; Kiemeney LA; Lindholt JS; Hughes A; Bradley DT; Stirrups K; Golledge J; Norman PE; Powell JT; Humphries SE; Hamby SE; Goodall AH; Nelson CP; Sakalihasan N; Courtois A; Ferrell RE; Eriksson P; Folkersen L; Franco-Cereceda A; Eicher JD; Johnson AD; Betsholtz C; Ruusalepp A; Franzen O; Schadt EE; Bjorkegren JLM; Lipovich L; Drolet AM; Verhoeven EL; Zeebregts CJ; Geelkerken RH; van Sambeek MR; van Sterkenburg SM; de Vries J-P; Stefansson K; Thompson JR; de Bakker PIW; Deloukas P; Sayers RD; Harrison SC; van Rij AM; Samani NJ; Bown MJ
Article: EXPERIMENTAL CELL RESEARCH. 2016;349(2):282-290
PDGF-A and PDGF-B induces cardiac fibrosis in transgenic mice
Gallini R; Lindblom P; Bondjers C; Betsholtz C; Andrae J
Article: CELL STEM CELL. 2016;19(6):738-751
Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT-Signaling Axis.
Rivera-Gonzalez GC; Shook BA; Andrae J; Holtrup B; Bollag K; Betsholtz C; Rodeheffer MS; Horsley V
Article: SCIENTIFIC REPORTS. 2016;6:35108
Analysis of the brain mural cell transcriptome
He L; Vanlandewijck M; Raschperger E; Mae MA; Jung B; Lebouvier T; Ando K; Hofmann J; Keller A; Betsholtz C
Article: SCIENCE. 2016;353(6301):827-830
Cardiometabolic risk loci share downstream cis- and trans-gene regulation across tissues and diseases
Franzen O; Ermel R; Cohain A; Akers NK; Di Narzo A; Talukdar HA; Foroughi-Asl H; Giambartolomei C; Fullard JF; Sukhavasi K; Koks S; Gan L-M; Giannarelli C; Kovacic JC; Betsholtz C; Losic B; Michoel T; Hao K; Roussos P; Skogsberg J; Ruusalepp A; Schadt EE; Bjorkegren JLM
Article: NATURE COMMUNICATIONS. 2016;7:12092
Integrative functional genomics identifies regulatory mechanisms at coronary artery disease loci
Miller CL; Pjanic M; Wang T; Nguyen T; Cohain A; Lee JD; Perisic L; Hedin U; Kundu RK; Majmudar D; Kim JB; Wang O; Betsholtz C; Ruusalepp A; Franzen O; Assimes TL; Montgomery SB; Schadt EE; Bjorkegren JLM; Quertermous T
Article: SCIENTIFIC REPORTS. 2016;6:25955
A novel podocyte gene, semaphorin 3G, protects glomerular podocyte from lipopolysaccharide-induced inflammation.
Ishibashi R; Takemoto M; Akimoto Y; Ishikawa T; He P; Maezawa Y; Sakamoto K; Tsurutani Y; Ide S; Ide K; Kawamura H; Kobayashi K; Tokuyama H; Tryggvason K; Betsholtz C; Yokote K
Article: CLINICAL CANCER RESEARCH. 2016;22(10):2417-2426
An Endothelial Gene Signature Score Predicts Poor Outcome in Patients with Endocrine-Treated, Low Genomic Grade Breast Tumors
Tobin NP; Wennmalm K; Lindstrom LS; Foukakis T; He L; Genove G; Ostman A; Landberg G; Betsholtz C; Bergh J
Article: SCIENTIFIC REPORTS. 2016;6:25658
Trafficking of Endogenous Immunoglobulins by Endothelial Cells at the Blood-Brain Barrier
Villasenor R; Ozmen L; Messaddeq N; Gruninger F; Loetscher H; Keller A; Betsholtz C; Freskgard P-O; Collin L
Article: NATURE. 2016;532(7599):380-384
Age-dependent modulation of vascular niches for haematopoietic stem cells
Kusumbe AP; Ramasamy SK; Itkin T; Mae MA; Langen UH; Betsholtz C; Lapidot T; Adams RH
Article: BIOLOGY OPEN. 2016;5(4):461-474
A role for PDGF-C/PDGFRα signaling in the formation of the meningeal basement membranes surrounding the cerebral cortex
Andrae J; Gouveia L; Gallini R; He L; Fredriksson L; Nilsson I; Johansson BR; Eriksson U; Betsholtz C
Article: NATURE COMMUNICATIONS. 2016;7:11017
VEGFR2 pY949 signalling regulates adherens junction integrity and metastatic spread
Li X; Padhan N; Sjostrom EO; Roche FP; Testini C; Honkura N; Sainz-Jaspeado M; Gordon E; Bentley K; Philippides A; Tolmachev V; Dejana E; Stan RV; Vestweber D; Ballmer-Hofer K; Betsholtz C; Pietras K; Jansson L; Claesson-Welsh L
Article: ONCOGENE. 2016;35(6):748-760
TGF-β1-induced EMT promotes targeted migration of breast cancer cells through the lymphatic system by the activation of CCR7/CCL21-mediated chemotaxis
Pang M-F; Georgoudaki A-M; Lambut L; Johansson J; Tabor V; Hagikura K; Jin Y; Jansson M; Alexander JS; Nelson CM; Jakobsson L; Betsholtz C; Sunds M; Karlsson MCI; Fuxe J
Article: PLOS ONE. 2016;11(3):e0152276
Mice Lacking Platelet-Derived Growth Factor D Display a Mild Vascular Phenotype
Gladh H; Folestad EB; Muhl L; Ehnman M; Tannenberg P; Lawrence A-L; Betsholtz C; Eriksson U
Article: PLOS ONE. 2016;11(8):e0160930
Isoform-Specific Modulation of Inflammation Induced by Adenoviral Mediated Delivery of Platelet-Derived Growth Factors in the Adult Mouse Heart
Gallini R; Huusko J; Yla-Herttuala S; Betsholtz C; Andrae J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - RENAL PHYSIOLOGY. 2015;309(11):F955-F966
Knockdown of Tmem234 in zebrafish results in proteinuria
Rodriguez PQ; Oddsson A; Ebarasi L; He B; Hultenby K; Wernerson A; Betsholtz C; Tryggvason K; Patrakka J
Article: STEROIDS. 2015;99(Pt B):183-188
Increased flux of the plant sterols campesterol and sitosterol across a disrupted blood brain barrier
Saeed AA; Genove G; Li T; Huelshorst F; Betsholtz C; Bjoerkhem I; Luejohann D
Article: CELL REPORTS. 2015;10(10):1708-1721
cKit Lineage Hemogenic Endothelium-Derived Cells Contribute to Mesenteric Lymphatic Vessels
Stanczuk L; Martinez-Corral I; Ulvmar MH; Zhang Y; Lavina B; Fruttiger M; Adams RH; Saur D; Betsholtz C; Ortega S; Alitalo K; Graupera M; Makinen T
Article: SCIENCE. 2015;347(6226):1138-1142
Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq
Zeisel A; Munoz-Manchado AB; Codeluppi S; Lonnerberg P; La Manno G; Jureus A; Marques S; Munguba H; He L; Betsholtz C; Rolny C; Castelo-Branco G; Hjerling-Leffler J; Linnarsson S
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2015;35(2):409-420
Notch3 Is Necessary for Blood Vessel Integrity in the Central Nervous System
Henshall TL; Keller A; He L; Johansson BR; Wallgard E; Raschperger E; Mae MA; Jin S; Betsholtz C; Lendahl U
Article: DEVELOPMENTAL CELL. 2015;32(1):97-108
Reverse Genetic Screening Reveals Poor Correlation between Morpholino-Induced and Mutant Phenotypes in Zebrafish
Kok FO; Shin M; Ni C-W; Gupta A; Grosse AS; van Impel A; Kirchmaier BC; Peterson-Maduro J; Kourkoulis G; Male I; DeSantis DF; Sheppard-Tindell S; Ebarasi L; Betsholtz C; Schulte-Merker S; Wolfe SA; Lawson ND
Article: PLOS ONE. 2015;10(11):e0143407
Functional Characterization of Germline Mutations in PDGFB and PDGFRB in Primary Familial Brain Calcification
Vanlandewijck M; Lebouvier T; Mae MA; Nahar K; Hornemann S; Kenkel D; Cunha SI; Lennartsson J; Boss A; Heldin C-H; Keller A; Betsholtz C
Article: PLOS ONE. 2015;10(9):e0137949
Gpr116 Receptor Regulates Distinctive Functions in Pneumocytes and Vascular Endothelium
Niaudet C; Hofmann JJ; Mae MA; Jung B; Gaengel K; Vanlandewijck M; Ekvarn E; Salvado MD; Mehlem A; Al Sayegh S; He L; Lebouvier T; Castro-Freire M; Katayama K; Hultenby K; Moessinger C; Tannenberg P; Cunha S; Pietras K; Lavina B; Hong J; Berg T; Betsholtz C
Article: PLOS ONE. 2015;10(3):e0122067
Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin
Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlen M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2014;25(12):2764-2777
Lmx1b and FoxC Combinatorially Regulate Podocin Expression in Podocytes
He B; Ebarasi L; Zhao Z; Guo J; Ojala JRM; Hultenby K; De Val S; Betsholtz C; Tryggvason K
Article: DEVELOPMENT. 2014;141(23):4489-4499
Excessive vascular sprouting underlies cerebral hemorrhage in mice lacking αVβ8-TGFβ signaling in the brain
Arnold TD; Niaudet C; Pang M-F; Siegenthaler J; Gaengel K; Jung B; Ferrero GM; Mukouyama Y-S; Fuxe J; Akhurst R; Betsholtz C; Sheppard D; Reichardt LF
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2014;34(9):2068-2077
Lim Domain Binding 2 A Key Driver of Transendothelial Migration of Leukocytes and Atherosclerosis
Shang M-M; Talukdar HA; Hofmann JJ; Niaudet C; Asl HF; Jain RK; Rossignoli A; Cedergren C; Silveira A; Gigante B; Leander K; de Faire U; Hamsten A; Ruusalepp A; Melander O; Ivert T; Michoel T; Schadt EE; Betsholtz C; Skogsberg J; Bjorkegren JLM
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2014;289(34):23712-23722
Effects of a Disrupted Blood-Brain Barrier on Cholesterol Homeostasis in the Brain
Saeed AA; Genove G; Li T; Luetjohann D; Olin M; Mast N; Pikuleva IA; Crick P; Wang Y; Griffiths W; Betsholtz C; Bjorkhem I
Article: BRAIN PATHOLOGY. 2014;24(4):387-395
PDGF, pericytes and the pathogenesis of idiopathic basal ganglia calcification (IBGC).
Betsholtz C; Keller A
Article: PLOS ONE. 2014;9(8):e105477
Characterization of Platelet-Derived Growth Factor-A Expression in Mouse Tissues Using a lacZ Knock-In Approach
Andrae J; Gouveia L; He L; Betsholtz C
Article: NATURE COMMUNICATIONS. 2014;5:3195
Clonal culturing of human embryonic stem cells on laminin-521/E-cadherin matrix in defined and xeno-free environment
Rodin S; Antonsson L; Niaudet C; Simonson OE; Salmela E; Hansson EM; Domogatskaya A; Xiao Z; Damdimopoulou P; Sheikhi M; Inzunza J; Nilsson A-S; Baker D; Kuiper R; Sun Y; Blennow E; Nordenskjold M; Grinnemo K-H; Kere J; Betsholtz C; Hovatta O; Tryggvason K
Article: NATURE MEDICINE. 2013;19(12):1617-1624
Targeting of α_v integrin identifies a core molecular pathway that regulates fibrosis in several organs
Henderson NC; Arnold TD; Katamura Y; Giacomini MM; Rodriguez JD; McCarty JH; Pellicoro A; Raschperger E; Betsholtz C; Ruminski PG; Griggs DW; Prinsen MJ; Maher JJ; Iredale JP; Lacy-Hulbert A; Adams RH; Sheppard D
Article: MOLECULAR AND CELLULAR BIOLOGY. 2013;33(20):4030-4040
Analysis of Mice Lacking the Heparin-Binding Splice Isoform of Platelet-Derived Growth Factor A
Andrae J; Ehrencrona H; Gallini R; Lal M; Ding H; Betsholtz C
Article: NATURE GENETICS. 2013;45(9):1077-1082
Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice
Keller A; Westenberger A; Sobrido MJ; Garcia-Murias M; Domingo A; Sears RL; Lemos RR; Ordonez-Ugalde A; Nicolas G; Gomes da Cunha JE; Rushing EJ; Hugelshofer M; Wurnig MC; Kaech A; Reimann R; Lohmann K; Dobricic V; Carracedo A; Petrovic I; Miyasaki JM; Abakumova I; Mae MA; Raschperger E; Zatz M; Zschiedrich K; Klepper J; Spiteri E; Prieto JM; Navas I; Preuss M; Dering C; Jankovic M; Paucar M; Svenningsson P; Saliminejad K; Khorshid HRK; Novakovic I; Aguzzi A; Boss A; Le Ber I; Defer G; Hannequin D; Kostic VS; Campion D; Geschwind DH; Coppola G; Betsholtz C; Klein C; Oliveira JRM
Article: VASCULAR CELL. 2013;5(1):4
The importance of microglia in the development of the vasculature in the central nervous system.
Arnold T; Betsholtz C
Article: PLOS ONE. 2013;8(12):e83133
Wtip- and Gadd45a-Interacting Protein Dendrin Is Not Crucial for the Development or Maintenance of the Glomerular Filtration Barrier
Xiao Z; Rodriguez PQ; He L; Betsholtz C; Tryggvason K; Patrakka J
Article: KIDNEY INTERNATIONAL. 2013;83(1):63-71
Neuronal proteins are novel components of podocyte major processes and their expression in glomerular crescents supports their role in crescent formation
Sistani L; Rodriguez PQ; Hultenby K; Uhlen M; Betsholtz C; Jalanko H; Tryggvason K; Wernerson A; Patrakka J
Article: KIDNEY INTERNATIONAL. 2012;82(10):1071-1083
Plekhh2, a novel podocyte protein downregulated in human focal segmental glomerulosclerosis, is involved in matrix adhesion and actin dynamics
Perisic L; Lal M; Hulkko J; Hultenby K; Onfelt B; Sun Y; Duner F; Patrakka J; Betsholtz C; Uhlen M; Brismar H; Tryggvason K; Wernerson A; Pikkarainen T
Article: DEVELOPMENTAL CELL. 2012;23(3):587-599
The Sphingosine-1-Phosphate Receptor S1PR1 Restricts Sprouting Angiogenesis by Regulating the Interplay between VE-Cadherin and VEGFR2
Gaengel K; Niaudet C; Hagikura K; Siemsen BL; Muhl L; Hofmann JJ; Ebarasi L; Nystrom S; Rymo S; Chen LL; Pang M-F; Jin Y; Raschperger E; Roswall P; Schulte D; Benedito R; Larsson J; Hellstrom M; Fuxe J; Uhlen P; Adams R; Jakobsson L; Majumdar A; Vestweber D; Uv A; Betsholtz C
Article: NATURE. 2012;485(7399):512-516
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Bell RD; Winkler EA; Singh I; Sagare AP; Deane R; Wu Z; Holtzman DM; Betsholtz C; Armulik A; Sallstrom J; Berk BC; Zlokovic BV
Article: AMERICAN JOURNAL OF PATHOLOGY. 2012;180(3):1136-1144
Platelet-Derived Growth Factor C Deficiency in C57BL/6 Mice Leads to Abnormal Cerebral Vascularization, Loss of Neuroependymal Integrity, and Ventricular Abnormalities
Fredriksson L; Nilsson I; Su EJ; Andrae J; Ding H; Betsholtz C; Eriksson U; Lawrence DA
Article: PLOS ONE. 2012;7(11):e50818
The Endocytic Adaptor Eps15 Controls Marginal Zone B Cell Numbers
Pozzi B; Amodio S; Lucano C; Sciullo A; Ronzoni S; Castelletti D; Adler T; Treise I; Betsholtz IH; Rathkolb B; Busch DH; Wolf E; Fuchs H; Gailus-Durner V; de Angelis MH; Betsholtz C; Casola S; Di Fiore PP; Offenhaeuser N
Article: DEVELOPMENTAL DYNAMICS. 2011;240(12):2646-2656
Deficiency in Crumbs Homolog 2 (Crb2) Affects Gastrulation and Results in Embryonic Lethality in Mice
Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainan T; Vainio S; Tryggvason K
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2011;22(11):2037-2046
Glcci1 Deficiency Leads to Proteinuria
Nishibori Y; Katayama K; Parikka M; Oddsson A; Nukui M; Hultenby K; Wernerson A; He B; Ebarasi L; Raschperger E; Norlin J; Uhlen M; Patrakka J; Betsholtz C; Tryggvason K
Article: KIDNEY INTERNATIONAL. 2011;80(10):1045-1054
Pdlim2 is a novel actin-regulating protein of podocyte foot processes
Sistani L; Duner F; Udumala S; Hultenby K; Uhlen M; Betsholtz C; Tryggvason K; Wernerson A; Patrakka J
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2011;301(3):E517-E526
Loss of PDGF-B activity increases hepatic vascular permeability and enhances insulin sensitivity
Raines SM; Richards OC; Schneider LR; Schueler KL; Rabaglia ME; Oler AT; Stapleton DS; Genove G; Dawson JA; Betsholtz C; Attie AD
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2011;22(6):1019-1023
Podocin-Green Fluorescence Protein Allows Visualization and Functional Analysis of Podocytes
He B; Ebarasi L; Hultenby K; Tryggvason K; Betsholtz C
Article: PLOS ONE. 2011;6(1):e15846
A Two-Way Communication between Microglial Cells and Angiogenic Sprouts Regulates Angiogenesis in Aortic Ring Cultures
Rymo SF; Gerhardt H; Sand FW; Lang R; Uv A; Betsholtz C
Article: NEPHRON. 2011;118(3):e39-e48
Glomerular Podocytes Express Type 1 Adenylate Cyclase: Inactivation Results in Susceptibility to Proteinuria
Xiao Z; He L; Takemoto M; Jalanko H; Chan GC; Storm DR; Betsholtz C; Tryggvason K; Patrakka J
Article: NEPHRON. 2011;117(2):e39-e46
Expression of Novel Podocyte-Associated Proteins sult1b1 and ankrd25
Xu X; Patrakka J; Sistani L; Uhlen M; Jalanko H; Betsholtz C; Tryggvason K
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2011;31(1):151-159
Differential Endothelial Transcriptomics Identifies Semaphorin 3G as a Vascular Class 3 Semaphorin
Kutschera S; Weber H; Weick A; De Smet F; Genove G; Takemoto M; Prahst C; Riedel M; Mikelis C; Baulande S; Champseix C; Kummerer P; Conseiller E; Multon M-C; Heroult M; Bicknell R; Carmeliet P; Betsholtz C; Augustin HG
Article: NATURE. 2010;468(7323):557-561
Pericytes regulate the blood-brain barrier
Armulik A; Genove G; Mae M; Nisancioglu MH; Wallgard E; Niaudet C; He L; Norlin J; Lindblom P; Strittmatter K; Johansson BR; Betsholtz C
Article: DEVELOPMENTAL DYNAMICS. 2010;239(8):2307-2317
Cardiac Malformations in Pdgfrα Mutant Embryos Are Associated With Increased Expression of WT1 and Nkx2.5 in the Second Heart Field
Bax NAM; Bleyl SB; Gallini R; Wisse LJ; Hunter J; Van Oorschot AAM; Mahtab EAF; Lie-Venema H; Goumans M-J; Betsholtz C; Gittenberger-de Groot AC
Article: CANCER RESEARCH. 2010;70(12):5109-5115
The Absence of Pericytes Does Not Increase the Sensitivity of Tumor Vasculature to Vascular Endothelial Growth Factor-A Blockade
Nisancioglu MH; Betsholtz C; Genove G
Article: INTERNATIONAL JOURNAL OF CANCER. 2009;125(8):1814-1825
Antibodies blocking adhesion and matrix binding domains of laminin-332 inhibit tumor growth and metastasis in vivo
Salo S; Boutaud A; Hansen AJ; He L; Sun Y; Morales S; Venturini A; Martin P; Nokelainen P; Betsholtz C; Mathiasen IS; Tryggvason K
Article: DEVELOPMENTAL BIOLOGY. 2009;334(1):1-9
A reverse genetic screen in the zebrafish identifies crb2b as a regulator of the glomerular filtration barrier
Ebarasi L; He L; Hultenby K; Takemoto M; Betsholtz C; Tryggvason K; Majumdar A
Article: CANCER RESEARCH. 2009;69(5):2141-2148
Dysfunctional Microvasculature as a Consequence of Shb Gene Inactivation Causes Impaired Tumor Growth
Funa NS; Kriz V; Zang G; Calounova G; Akerblom B; Mares J; Larsson E; Sun Y; Betsholtz C; Welsh M
Article: AMERICAN JOURNAL OF NEPHROLOGY. 2009;29(6):558-570
Glomerular Transcriptome Changes Associated with Lipopolysaccharide-Induced Proteinuria
Sun Y; He L; Takemoto M; Patrakka J; Pikkarainen T; Genove G; Norlin J; Truve K; Tryggvason K; Betsholtz C
Article: CANCER RESEARCH. 2009;69(1):369-378
Paracrine Signaling by Platelet-Derived Growth Factor-CC Promotes Tumor Growth by Recruitment of Cancer-Associated Fibroblasts
Anderberg C; Li H; Fredriksson L; Andrae J; Betsholtz C; Li X; Eriksson U; Pietras K
Article: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2008;28(8):1469-1476
Identification of a core set of 58 gene transcripts with broad and specific expression in the microvasculature
Wallgard E; Larsson E; He L; Hellstrom M; Armulik A; Nisancioglu MH; Genove G; Lindahl P; Betsholtz C
Article: NATURE. 2008;454(7204):656-660
Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tammela T; Zarkada G; Wallgard E; Murtomaki A; Suchting S; Wirzenius M; Waltari M; Hellstrom M; Schomber T; Peltonen R; Freitas C; Duarte A; Isoniemi H; Laakkonen P; Christofori G; Yla-Herttuala S; Shibuya M; Pytowski B; Eichmann A; Betsholtz C; Alitalo K
Article: NATURE MEDICINE. 2008;14(7):731-737
Activation of PDGF-CC by tissue plasminogen activator impairs blood-brain barrier integrity during ischemic stroke
Su EJ; Fredriksson L; Geyer M; Folestad E; Cale J; Andrae J; Gao Y; Pietras K; Mann K; Yepes M; Strickland DK; Betsholtz C; Eriksson U; Lawrence DA
Article: MOLECULAR AND CELLULAR BIOLOGY. 2008;28(7):2324-2331
Generation and characterization of rgs5 mutant mice
Nisancioglu MH; Mahoney WMJ; Kimmel DD; Schwartz SM; Betsholtz C; Genove G
Article: KIDNEY INTERNATIONAL. 2008;73(6):697-704
Nephrin is involved in podocyte maturation but not survival during glomerular development
Done SC; Takemoto M; He L; Sun Y; Hultenby K; Betsholtz C; Tryggvason K
Article: DEVELOPMENTAL DYNAMICS. 2008;237(2):494-503
PDGF-B signaling is important for murine cardiac development: Its role in developing atrioventricular valves, coronaries, and cardiac innervation
Van den Akker NMS; Winkel LCJ; Nisancioglu MH; Maas S; Wisse LJ; Armulik A; Poelmann RE; Lie-Venema H; Betsholtz C; Gittenberger-de Groot AC
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2008;19(2):260-268
The glomerular transcriptome and a predicted protein-protein interaction network
He L; Sun Y; Takemoto M; Norlin J; Tryggvason K; Samuelsson T; Betsholtz C
Article: KIDNEY INTERNATIONAL. 2007;71(9):889-900
Glomerulus-specific mRNA transcripts and proteins identified through kidney expressed sequence tag database analysis
He L; Sun Y; Patrakka J; Mostad P; Norlin J; Xiao Z; Andrae J; Tryggvason K; Samuelsson T; Betsholtz C; Takemoto M
Article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2007;18(3):689-697
Expression and subcellular distribution of novel glomerulus-associated proteins dendrin, ehd3, sh2d4a, plekhh2, and 2310066E14Rik
Patrakka J; Xiao Z; Nukui M; Takemoto M; He L; Oddsson A; Perisic L; Kaukinen A; Szigyarto CA-K; Uhlen M; Jalanko H; Betsholtz C; Tryggvason K
Article: NATURE. 2007;445(7129):776-780
Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis
Hellstroem M; Phng L-K; Hofmann JJ; Wallgard E; Coultas L; Lindblom P; Alva J; Nilsson A-K; Karlsson L; Gaiano N; Yoon K; Rossant J; Iruela-Arispe ML; Kalen M; Gerhardt H; Betsholtz C
Article: GENES & DEVELOPMENT. 2007;21(3):316-331
Defective N-sulfation of heparan sulfate proteoglycans limits PDGF-BB binding and pericyte recruitment in vascular development
Abramsson A; Kurup S; Busse M; Yamada S; Lindblom P; Schallmeiner E; Stenzel D; Sauvaget D; Ledin J; Ringvall M; Landegren U; Kjellen L; Bondjers G; Li J-P; Lindahl U; Spillmann D; Betsholtz C; Gerhardt H
Article: NEPHRON. 2007;106(2):e32-e36
The glomerular transcriptome and Proteome
Betsholtz C; He L; Takemoto M; Norlin J; Sun Y; Patrakka J; Tryggvason K
Article: CELL. 2006;127(1):213-226
Increased ethanol resistance and consumption in Eps8 knockout mice correlates with altered actin dynamics
Offenhauser N; Castelletti D; Mapelli L; Soppo BE; Regondi MC; Rossi P; D'Angelo E; Frassoni C; Amadeo A; Tocchetti A; Pozzi B; Disanza A; Guarnieri D; Betsholtz C; Scita G; Helberlein U; Di Fiore PP
Article: BLOOD. 2006;108(6):1877-1886
Platelet-derived growth factor receptor-β promotes early endothelial cell differentiation
Rolny C; Nilsson I; Magnusson P; Armulik A; Jakobsson L; Wentzel P; Lindblom P; Norlin J; Betsholtz C; Heuchel R; Welsh M; Claesson-Welsh L
Article: THE FASEB JOURNAL. 2006;20(10):1703-1705
Microarray analysis of blood microvessels from PDGF-RB and PDGF-Rβ mutant mice identifies novel markers for brain pericytes
Bondjers C; He L; Takemoto M; Norlin J; Asker N; Mats HRM; Lindahl P; Betsholtz C
Article: EMBO JOURNAL. 2006;25(5):1160-1174
Large-scale identification of genes implicated in kidney glomerulus development and function
Takemoto M; He LQ; Norlin J; Patrakka J; Xiao ZJ; Petrova T; Bondjers C; Asp J; Wallgard E; Sun Y; Samuelsson T; Mostad P; Lundin S; Miura N; Sado Y; Alitalo K; Quaggin SE; Tryggvason K; Betsholtz C
Article: JOURNAL OF CLINICAL INVESTIGATION. 2006;116(3):642-651
Pericytes limit tumor cell metastasis
Xian XJ; Håkansson J; Ståhlberg A; Lindblom P; Betsholtz C; Gerhardt H; Semb H
Article: AMERICAN JOURNAL OF PATHOLOGY. 2005;167(3):901-912
The absence of platelet-derived growth factor-B in circulating cells promotes immune and inflammatory responses in atherosclerosis-prone ApoE-/- mice.
Tang J; Kozaki K; Farr AG; Martin PJ; Lindahl P; Betsholtz C; Raines EW
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 2005;95(4):859-867
Identification of transcripts specific for physiological gene activation by platelet-derived growth factor (PDGF)-B in intact brain tissue.
Renner O; Romero L; Carnero A; Betsholtz C; Euler M
Article: DEVELOPMENTAL DYNAMICS. 2004;231(3):503-509
Neuropilin-1 is required for endothelial tip cell guidance in the developing central nervous system.
Gerhardt H; Ruhrberg C; Abramsson A; Fujisawa H; Shima D; Betsholtz C
Article: NATURE GENETICS. 2004;36(10):1111-1116
A specific requirement for PDGF-C in palate formation and PDGFR-alpha signaling.
Ding H; Wu X; Boström H; Kim I; Wong N; Tsoi B; O'Rourke M; Koh GY; Soriano P; Betsholtz C; Hart TC; Marazita ML; Field LL; Tam PPL; Nagy A
Article: JOURNAL OF CELL SCIENCE. 2004;117(Pt 16):3481-3488
Under stress, the absence of intermediate filaments from Müller cells in the retina has structural and functional consequences.
Lundkvist A; Reichenbach A; Betsholtz C; Carmeliet P; Wolburg H; Pekny M
Article: DEVELOPMENTAL BIOLOGY. 2004;270(2):427-442
The mesenchymal alpha11beta1 integrin attenuates PDGF-BB-stimulated chemotaxis of embryonic fibroblasts on collagens.
Popova SN; Rodriguez-Sánchez B; Lidén A; Betsholtz C; Van Den Bos T; Gullberg D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(22):8420-8424
Cytokine detection by antibody-based proximity ligation.
Gullberg M; Gústafsdóttir SM; Schallmeiner E; Jarvius J; Bjarnegård M; Betsholtz C; Landegren U; Fredriksson S
Article: DEVELOPMENT. 2004;131(8):1847-1857
Endothelium-specific ablation of PDGFB leads to pericyte loss and glomerular, cardiac and placental abnormalities.
Bjarnegård M; Enge M; Norlin J; Gustafsdottir S; Fredriksson S; Abramsson A; Takemoto M; Gustafsson E; Fässler R; Betsholtz C
Article: CANCER RESEARCH. 2004;64(8):2725-2733
Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate
Furuhashi M; Sjöblom T; Abramsson A; Ellingsen J; Micke P; Li H; Bergsten-Folestad E; Eriksson U; Heuchel R; Betsholtz C; Heldin CH; Östman A
Article: NATURE IMMUNOLOGY. 2004;5(1):74-80
Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins.
Karkkainen MJ; Haiko P; Sainio K; Partanen J; Taipale J; Petrova TV; Jeltsch M; Jackson DG; Talikka M; Rauvala H; Betsholtz C; Alitalo K
Article: BIOLOGY OF REPRODUCTION. 2004;70(1):168-177
Expression of platelet-derived growth factor (PDGF) in the epididymis and analysis of the epididymal development in PDGF-A, PDGF-B, and PDGF receptor beta deficient mice.
Basciani S; Mariani S; Arizzi M; Brama M; Ricci A; Betsholtz C; Bondjers C; Ricci G; Catizone A; Galdieri M; Spera G; Gnessi L
Article: JOURNAL OF CLINICAL INVESTIGATION. 2003;112(8):1142-1151
Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors.
Abramsson A; Lindblom P; Betsholtz C
Article: DEVELOPMENTAL BIOLOGY. 2003;262(2):225-241
Cortical and retinal defects caused by dosage-dependent reductions in VEGF-A paracrine signaling.
Haigh JJ; Morelli PI; Gerhardt H; Haigh K; Tsien J; Damert A; Miquerol L; Muhlner U; Klein R; Ferrara N; Wagner EF; Betsholtz C; Nagy A
Article: GENES & DEVELOPMENT. 2003;17(15):1835-1840
Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall.
Lindblom P; Gerhardt H; Liebner S; Abramsson A; Enge M; Hellstrom M; Backstrom G; Fredriksson S; Landegren U; Nystrom HC; Bergstrom G; Dejana E; Ostman A; Lindahl P; Betsholtz C
Article: JOURNAL OF CELL BIOLOGY. 2003;161(6):1163-1177
VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia.
Gerhardt H; Golding M; Fruttiger M; Ruhrberg C; Lundkvist A; Abramsson A; Jeltsch M; Mitchell C; Alitalo K; Shima D; Betsholtz C
Article: AMERICAN JOURNAL OF PATHOLOGY. 2003;162(3):721-729
Transcription profiling of platelet-derived growth factor-B-deficient mouse embryos identifies RGS5 as a novel marker for pericytes and vascular smooth muscle cells.
Bondjers C; Kalén M; Hellström M; Scheidl SJ; Abramsson A; Renner O; Lindahl P; Cho H; Kehrl J; Betsholtz C
Article: THE FASEB JOURNAL. 2003;17(3):440-442
Pericyte-specific expression of Rgs5: implications for PDGF and EDG receptor signaling during vascular maturation.
Cho H; Kozasa T; Bondjers C; Betsholtz C; Kehrl JH
Article: GENOMICS. 2003;81(2):234-244
In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure.
Tocchetti A; Confalonieri S; Scita G; Di Fiore PP; Betsholtz C
Article: NEUROCHEMICAL RESEARCH. 2003;28(2):271-279
Neuron-specific ablation of PDGF-B is compatible with normal central nervous system development and astroglial response to injury.
Enge M; Wilhelmsson U; Abramsson A; Stakeberg J; Kühn R; Betsholtz C; Pekny M
Article: GENES & DEVELOPMENT. 2002;16(20):2684-2698
Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis.
Ruhrberg C; Gerhardt H; Golding M; Watson R; Ioannidou S; Fujisawa H; Betsholtz C; Shima DT
Article: AMERICAN JOURNAL OF PATHOLOGY. 2002;161(4):1395-1407
Blockade of platelet-derived growth factor or its receptors transiently delays but does not prevent fibrous cap formation in ApoE null mice.
Kozaki K; Kaminski WE; Tang J; Hollenbach S; Lindahl P; Sullivan C; Yu J-C; Abe K; Martin PJ; Ross R; Betsholtz C; Giese NA; Raines EW
Article: DIABETES. 2002;51(10):3107-3112
Pericytes and the pathogenesis of diabetic retinopathy.
Hammes H-P; Lin J; Renner O; Shani M; Lundqvist A; Betsholtz C; Brownlee M; Deutsch U
Article: AMERICAN JOURNAL OF PATHOLOGY. 2002;161(3):799-805
A new method for large scale isolation of kidney glomeruli from mice.
Takemoto M; Asker N; Gerhardt H; Lundkvist A; Johansson BR; Saito Y; Betsholtz C
Article: EMBO JOURNAL. 2002;21(16):4307-4316
Endothelium-specific platelet-derived growth factor-B ablation mimics diabetic retinopathy.
Enge M; Bjarnegård M; Gerhardt H; Gustafsson E; Kalén M; Asker N; Hammes H-P; Shani M; Fässler R; Betsholtz C
Article: EXPERIMENTAL CELL RESEARCH. 2002;278(1):31-44
Mouse notch 3 expression in the pre- and postnatal brain: Relationship to the stroke and dementia syndrome CADASIL
Prakash N; Hansson E; Betsholtz C; Mitsiadis T; Lendahl U
Article: DEVELOPMENTAL DYNAMICS. 2002;223(1):155-162
PDGF-A/PDGF alpha-receptor signaling is required for lung growth and the formation of alveoli but not for early lung branching morphogenesis.
Boström H; Gritli-Linde A; Betsholtz C
Article: CIRCULATION. 2002;105(1):112-117
Analysis of mural cell recruitment to tumor vessels.
Abramsson A; Berlin O; Papayan H; Paulin D; Shani M; Betsholtz C
Article: MECHANISMS OF DEVELOPMENT. 2002;110(1-2):187-191
Expression analysis of PDGF-C in adult and developing mouse tissues.
Aase K; Abramsson A; Karlsson L; Betsholtz C; Eriksson U
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2001;1520(2):115-123
Characterization of a nicotinamide nucleotide transhydrogenase gene from the green alga Acetabularia acetabulum and comparison of its structure with those of the corresponding genes in mouse and Caenorhabditis elegans.
Arkblad EL; Betsholtz C; Mandoli D; Rydström J
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001;98(16):9407-9412
Hyperalgesia, anxiety, and decreased hypoxic neuroprotection in mice lacking the adenosine A₁ receptor
Johansson B; Halldner L; Dunwiddie TV; Masino SA; Poelchen W; Giménez-Llort L; Escorihuela RM; Fernández-Teruel A; Wiesenfeld-Hallin Z; Xu XJ; Hårdemark A; Betsholtz C; Herlenius E; Fredholm BB
Article: CIRCULATION. 2001;104(3):358-364
Vascular endothelial growth factor-B-deficient mice display an atrial conduction defect
Aase K; von Euler G; Li X; Pontén A; Thorén P; Cao R; Cao Y; Olofsson B; Gebre-Medhin S; Pekny M; Alitalo K; Betsholtz C; Eriksson U
Article: JOURNAL OF CELL BIOLOGY. 2001;153(3):543-554
Lack of pericytes leads to endothelial hyperplasia and abnormal vascular morphogenesis
Hellström M; Gerhardt H; Kalén M; Li XR; Eriksson U; Wolburg H; Betsholtz C
Article: BLOOD. 2001;97(7):1990-1998
Basis of hematopoietic defects in platelet-derived growth factor (PDGF)-B and PDGF beta-receptor null mice.
Kaminski WE; Lindahl P; Lin NL; Broudy VC; Crosby JR; Hellström M; Swolin B; Bowen-Pope DF; Martin PJ; Ross R; Betsholtz C; Raines EW
Article: DEVELOPMENT. 2000;127(16):3457-3466
Abnormal gastrointestinal development in PDGF-A and PDGFR-(alpha) deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis.
Karlsson L; Lindahl P; Heath JK; Betsholtz C
Article: JOURNAL OF CELL BIOLOGY. 2000;149(5):1019-1026
Leydig cell loss and spermatogenic arrest in platelet-derived growth factor (PDGF)-A-deficient mice.
Gnessi L; Basciani S; Mariani S; Arizzi M; Spera G; Wang C; Bondjers C; Karlsson L; Betsholtz C
Article: NATURE CELL BIOLOGY. 2000;2(5):302-309
PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor.
Li X; Pontén A; Aase K; Karlsson L; Abramsson A; Uutela M; Bäckström G; Hellström M; Boström H; Li H; Soriano P; Betsholtz C; Heldin CH; Alitalo K; Ostman A; Eriksson U
Article: AMERICAN JOURNAL OF PHYSIOLOGY - ENDOCRINOLOGY AND METABOLISM. 2000;278(4):E684-E691
Islet amyloid polypeptide (amylin)-deficient mice develop a more severe form of alloxan-induced diabetes.
Mulder H; Gebre-Medhin S; Betsholtz C; Sundler F; Ahrén B
Article: JOURNAL OF CLINICAL LIGAND ASSAY. 2000;23(3):206-213
Functions of platelet-derived growth factor and its receptors deduced from gene inactivation in mice
Betsholtz C
Article: JOURNAL OF EXPERIMENTAL MEDICINE (JEM). 1999;190(7):915-922
Absence of epithelial immunoglobulin A transport, with increased mucosal leakiness, in polymeric immunoglobulin receptor/secretory component-deficient mice.
Johansen FE; Pekna M; Norderhaug IN; Haneberg B; Hietala MA; Krajci P; Betsholtz C; Brandtzaeg P
Article: NATURE. 1999;401(6750):290-293
EPS8 and E3B1 transduce signals from Ras to Rac.
Scita G; Nordstrom J; Carbone R; Tenca P; Giardina G; Gutkind S; Bjarnegård M; Betsholtz C; Di Fiore PP
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1999;274(34):23996-24006
Intermediate filament protein partnership in astrocytes.
Eliasson C; Sahlgren C; Berthold CH; Stakeberg J; Celis JE; Betsholtz C; Eriksson JE; Pekny M
Article: DEVELOPMENTAL BIOLOGY. 1999;212(1):124-136
PDGFB regulates the development of the labyrinthine layer of the mouse fetal placenta.
Ohlsson R; Falck P; Hellström M; Lindahl P; Boström H; Franklin G; Ahrlund-Richter L; Pollard J; Soriano P; Betsholtz C
Article: DEVELOPMENT. 1999;126(14):3047-3055
Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse
Hellström M; Kalén M; Lindahl P; Abramsson A; Betsholtz C
Article: DEVELOPMENT. 1999;126(12):2611-2621
Roles for PDGF-A and sonic hedgehog in development of mesenchymal components of the hair follicle.
Karlsson L; Bondjers C; Betsholtz C
Article: JOURNAL OF CELL BIOLOGY. 1999;145(3):503-514
Abnormal reaction to central nervous system injury in mice lacking glial fibrillary acidic protein and vimentin
Pekny M; Johansson CB; Eliasson C; Stakeberg J; Wallén Å; Perlmann T; Lendahl U; Betsholtz C; Berthold CH; Frisén J
Article: DEVELOPMENT. 1999;126(3):457-467
Defective oligodendrocyte development and severe hypomyelination in PDGF-A knockout mice.
Fruttiger M; Karlsson L; Hall AC; Abramsson A; Calver AR; Boström H; Willetts K; Bertold CH; Heath JK; Betsholtz C; Richardson WD
Article: FEBS LETTERS. 1998;441(2):261-265
Targeted disruption of the mouse phospholipase C β3 gene results in early embryonic lethality
Wang S; Gebre-Medhin S; Betsholtz C; Stålberg P; Zhou YH; Larsson C; Weber G; Feinstein R; Öberg K; Gobl A; Skogseid B
Article: BRAIN RESEARCH. 1998;63(1):180-183
Reduced nociceptive behavior in islet amyloid polypeptide (amylin) knockout mice.
Gebre-Medhin S; Mulder H; Zhang Y; Sundler F; Betsholtz C
Article: BRAIN RESEARCH. 1998;62(1):77-81
Altered taurine release following hypotonic stress in astrocytes from mice deficient for GFAP and vimentin.
Ding M; Eliasson C; Betsholtz C; Hamberger A; Pekny M
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1998;250(2):271-277
Increased insulin secretion and glucose tolerance in mice lacking islet amyloid polypeptide (amylin).
Gebre-Medhin S; Mulder H; Pekny M; Westermark G; Törnell J; Westermark P; Sundler F; Ahrén B; Betsholtz C
Article: DEVELOPMENT. 1998;125(17):3313-3322
Paracrine PDGF-B/PDGF-Rbeta signaling controls mesangial cell development in kidney glomeruli.
Lindahl P; Hellström M; Kalén M; Karlsson L; Pekny M; Pekna M; Soriano P; Betsholtz C
Article: NEURON. 1998;20(5):869-882
Oligodendrocyte population dynamics and the role of PDGF in vivo.
Calver AR; Hall AC; Yu WP; Walsh FS; Heath JK; Betsholtz C; Richardson WD
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998;47(4):375-380
Mice deficient for the complement factor B develop and reproduce normally.
Pekna M; Hietala MA; Landin A; Nilsson AK; Lagerberg C; Betsholtz C; Pekny M
Article: GLIA. 1998;22(4):390-400
Impaired induction of blood-brain barrier properties in aortic endothelial cells by astrocytes from GFAP-deficient mice.
Pekny M; Stanness KA; Eliasson C; Betsholtz C; Janigro D
Article: EXPERIMENTAL CELL RESEARCH. 1998;239(2):332-343
GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density.
Pekny M; Eliasson C; Chien CL; Kindblom LG; Liem R; Hamberger A; Betsholtz C
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1998;47(1):25-29
Targeted disruption of the murine gene coding for the third complement component (C3).
Pekna M; Hietala MA; Rosklint T; Betsholtz C; Pekny M
Article: DEVELOPMENT. 1997;124(20):3943-3953
Alveogenesis failure in PDGF-A-deficient mice is coupled to lack of distal spreading of alveolar smooth muscle cell progenitors during lung development.
Lindahl P; Karlsson L; Hellström M; Gebre-Medhin S; Willetts K; Heath JK; Betsholtz C
Article: SCIENCE. 1997;277(5323):242-245
Pericyte loss and microaneurysm formation in PDGF-B-deficient mice.
Lindahl P; Johansson BR; Levéen P; Betsholtz C
Article: NEUROLOGY. 1996;47(2):449-453
Scrapie in mice deficient in apolipoprotein E or glial fibrillary acidic protein.
Tatzelt J; Maeda N; Pekny M; Yang SL; Betsholtz C; Eliasson C; Cayetano J; Camerino AP; DeArmond SJ; Prusiner SB
Article: CELL. 1996;85(6):863-873
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Bostrom H; Willetts K; Pekny M; Leveen P; Lindahl P; Hedstrand H; Pekna M; Hellstrom M; GebreMedhin S; Schalling M; Nilsson M; Kurland S; Tornell J; Heath JK; Betsholtz C
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 1996;1273(3):203-205
The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse.
Arkblad EL; Betsholtz C; Rydström J
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 1995;39(5):817-825
Role of platelet-derived growth factors in mouse development.
Betsholtz C
Article: CARCINOGENESIS. 1995;16(10):2515-2521
CHARACTERIZATION OF HUMAN BUCCAL EPITHELIAL-CELLS TRANSFECTED WITH THE SIMIAN-VIRUS-40 T-ANTIGEN GENE
KULKARNI PS; SUNDQVIST K; BETSHOLTZ C; HOGLUND P; WIMAN KG; ZHIVOTOVSKY B; BERTOLERO F; LIU Y; GRAFSTROM RC
Article: EMBO JOURNAL. 1995;14(8):1590-1598
Mice lacking glial fibrillary acidic protein display astrocytes devoid of intermediate filaments but develop and reproduce normally.
Pekny M; Levéen P; Pekna M; Eliasson C; Berthold CH; Westermark B; Betsholtz C
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Corrigendum: SCIENTIFIC REPORTS. 2019;9(1):10702
Claudin-3-deficient C57BL/6J mice display intact brain barriers (vol 9, 203, 2019)
Dias MC; Coisne C; Lazarevic I; Baden P; Hata M; Iwamoto N; Francisco DMF; Vanlandewijck M; He L; Baier FA; Stroka D; Bruggmann R; Lyck R; Enzmann G; Deutsch U; Betsholtz C; Furuse M; Tsukita S; Engelha B
Corrigendum: NATURE. 2018;560(7716):E3
A molecular atlas of cell types and zonation in the brain vasculature (vol 554, pg 475, 2018)
Vanlandewijck M; He L; Mae MA; Andrae J; Ando K; Del Gaudio F; Nahar K; Lebouvier T; Lavina B; Gouveia L; Sun Y; Raschperger E; Rasanen M; Zarb Y; Mochizuki N; Keller A; Lendahl U; Betsholtz C
Editorial comment: EMBO MOLECULAR MEDICINE. 2018;10(3):e8610
Cell-cell signaling in blood vessel development and function
Betsholtz C
Editorial comment: SCIENCE. 2016;351(6271):341-342
Oligodendrocytes follow blood vessel trails in the brain Brain microvasculature is a scaffold for neuroglial migration
Dejana E; Betsholtz C
Editorial comment: NATURE. 2016;529(7585):160-161
Transcriptional control of endothelial energy
Betsholtz C
Review: CELL. 2015;163(5):1064-1078
Establishment and Dysfunction of the Blood-Brain Barrier.
Zhao Z; Nelson AR; Betsholtz C; Zlokovic BV
Editorial comment: NATURE GENETICS. 2015;47(7):699-701
Lipid transport and human brain development
Betsholtz C
Corrigendum: PLOS ONE. 2015;10(5):e0126079
Schip1 Is a Novel Podocyte Foot Process Protein that Mediates Actin Cytoskeleton Rearrangements and Forms a Complex with Nherf2 and Ezrin (vol 10, e0122067, 2015)
Perisic L; Rodriguez PQ; Hultenby K; Sun Y; Lal M; Betsholtz C; Uhlen M; Wernerson A; Hedin U; Pikkarainen T; Tryggvason K; Patrakka J
Editorial comment: NATURE. 2014;509(7501):432-433
Double function at the blood-brain barrier
Betsholtz C
Corrigendum: VASCULAR CELL. 2013;5(1):12
Correction: The importance of microglia in the development of the vasculature in the central nervous system.
Arnold T; Betsholtz C
Editorial comment: NATURE CELL BIOLOGY. 2013;15(3):233-235
Endocytosis regulates VEGF signalling during angiogenesis
Gaengel K; Betsholtz C
Corrigendum: DEVELOPMENTAL DYNAMICS. 2012;241(2):431
Deficiency in crumbs homolog 2 (Crb2) affects gastrulation and results in embryonic lethality in mice (vol 240, pg 2646, 2011)
Xiao Z; Patrakka J; Nukui M; Chi L; Niu D; Betsholtz C; Pikkarainen T; Vainio S; Tryggvason K
Review: CURRENT PHARMACEUTICAL DESIGN. 2011;17(26):2750-2754
Getting to Know the Cast - Cellular Interactions and Signaling at the Neurovascular Unit
Mae M; Armulik A; Betsholtz C
Review: DEVELOPMENTAL CELL. 2011;21(2):193-215
Pericytes: Developmental, Physiological, and Pathological Perspectives, Problems, and Promises
Armulik A; Genove G; Betsholtz C
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2011;20(4):416-424
Zebrafish: a model system for the study of vertebrate renal development, function, and pathophysiology
Ebarasi L; Oddsson A; Hultenby K; Betsholtz C; Tryggvason K
Meeting abstract: JOURNAL OF THE NEUROLOGICAL SCIENCES. 2009;283(1-2):289
A gain-of-function approach to analyze the role of PDGF-B in pericyte recruitment to microvessels
Armulik A; Lindblom P; Norlin J; Betsholtz C
Review: ARTERIOSCLEROSIS, THROMBOSIS, AND VASCULAR BIOLOGY. 2009;29(5):630-638
Endothelial-Mural Cell Signaling in Vascular Development and Angiogenesis
Gaengel K; Genove G; Armulik A; Betsholtz C
Review: GENES & DEVELOPMENT. 2008;22(10):1276-1312
Role of platelet-derived growth factors in physiology and medicine
Andrae J; Gallini R; Betsholtz C
Published conference paper: CARDIOVASCULAR RESEARCH (CVR). 2006;71(3):557-565
Platelet-derived growth factor B retention is essential for development of normal structure and function of conduit vessels and capillaries
Nystrom HC; Lindblom P; Wickman A; Andersson I; Norlin J; Faldt J; Lindahl P; Skott O; Bjarnegard M; Fitzgerald SM; Caidahl K; Gan L-M; Betsholtz C; Bergstrom G
Published conference paper: BIOCHEMICAL SOCIETY TRANSACTIONS. 2006;34(Pt 3):454-455
Heparan sulphate requirement in platelet-derived growth factor B-mediated pericyte recruitment
Kurup S; Abramsson A; Li JP; Lindahl U; Kjellen L; Betsholtz C; Gerhardt H; Spillmann D
Review: EXPERIMENTAL CELL RESEARCH. 2006;312(5):623-629
Pericytes and vascular stability
von Tell D; Armulik A; Betsholtz C
Editorial comment: AMERICAN JOURNAL OF PHYSIOLOGY. HEART AND CIRCULATORY PHYSIOLOGY. 2006;290(2):H509-H511
Homeostatic functions of vascular endothelial growth factor in adult microvasculature
Betsholtz C; Armulik A
Review: METHODS IN MOLECULAR BIOLOGY. 2006;326:89-102
Nonradioactive in situ hybridization on frozen sections and whole mounts.
Asp J; Abramsson A; Betsholtz C
Review: CIRCULATION RESEARCH. 2005;97(6):512-523
Endothelial/pericyte interactions
Armulik A; Abramsson A; Betsholtz C
Review: EXS. 2005;(94):115-125
Role of pericytes in vascular morphogenesis.
Betsholtz C; Lindblom P; Gerhardt H
Review: CYTOKINE AND GROWTH FACTOR REVIEWS. 2004;15(4):215-228
Insight into the physiological functions of PDGF through genetic studies in mice.
Betsholtz C
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 2004;13(1):45-52
Role of platelet-derived growth factor in mesangium development and vasculopathies: lessons from platelet-derived growth factor and platelet-derived growth factor receptor mutations in mice.
Betsholtz C; Lindblom P; Bjarnegard M; Enge M; Gerhardt H; Lindahl P
Review: BIRTH DEFECTS RESEARCH PART C - EMBRYO TODAY: REVIEWS. 2003;69(4):272-285
Biology of platelet-derived growth factors in development.
Betsholtz C
Review: CELL AND TISSUE RESEARCH. 2003;314(1):15-23
Endothelial-pericyte interactions in angiogenesis.
Gerhardt H; Betsholtz C
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2003;4(2):62-63
The PDGF-B retention motif knockout mouse shows primary conduit vessel and renal dysfunction together with eccentric cardiac hypertrophy
Nyström H; Lindblom P; Wickman A; Andersson I; Norlin J; Lindah P; Bjarnegård M; Fitzgerald S; Gan LM; Betsholtz C; Bergström G
Review: BIOESSAYS. 2001;23(6):494-507
Developmental roles of platelet-derived growth factors.
Betsholtz C; Karlsson L; Lindahl P
Meeting abstract: EUROPEAN JOURNAL OF CANCER. 1999;35:s132
Eps8 end E3b1 medicate transduction of signals from Ras to Rac
Scita G; Tenca P; Panunzio M; Betsholtz C; Di Flore PP
Review: CURRENT TOPICS IN PATHOLOGY. 1999;93:27-33
Role of platelet-derived growth factors in angiogenesis and alveogenesis.
Lindahl P; Boström H; Karlsson L; Hellström M; Kalén M; Betsholtz C
Review: CURRENT OPINION IN LIPIDOLOGY. 1998;9(5):407-411
Endothelial-perivascular cell signaling in vascular development: lessons from knockout mice.
Lindahl P; Hellström M; Kalén M; Betsholtz C
Review: CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION. 1998;7(1):21-26
Not all myofibroblasts are alike: revisiting the role of PDGF-A and PDGF-B using PDGF-targeted mice.
Lindahl P; Betsholtz C
Published conference paper: KIDNEY INTERNATIONAL. 1997;51(5):1361-1369
Platelet-derived growth factor: a key regulator of connective tissue cells in embryogenesis and pathogenesis.
Betsholtz C; Raines EW
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Professor, Medicin, Huddinge, Karolinska Institutet, 2016-

Examina och utbildning

Docent, inriktn. experimentell patologi, Uppsala universitet, Uppsala universitet, 1987

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Yuyang Miao, 2021
Krishnapriya Loganathan, 2014

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