Camilla Engblom

Camilla Engblom

Biträdande Lektor
E-postadress: camilla.engblom@ki.se
Besöksadress: L8:03, CMM, Karolinska Universitetssjukhuset Solna, 17176 Stockholm
Postadress: K2 Medicin, Solna, K2 Imm o lung Villablanca E, 171 77 Stockholm

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2024 - 31 December 2027
    Despite the clinical success of immunotherapy, many cancer patients lack optimal treatment options. B cells and B cell-derived plasma cells (PC) have recently emerged as promising, yet untapped, therapeutic targets. Here, I propose to use cutting-edge, in-house developed, spatial transcriptomics-based approaches to systematically interrogate B/PC biology in tumor progression and immunotherapy responses. B lineage cells are compelling anti-cancer targets because they: i) infiltrate tumors and associate with positive prognosis and immunotherapy outcome across cancers, ii) present antigen to T cells, and iii) express clonal heritable B cell receptors (BCR) that confer exquisite molecular specificity. B cell receptors can be defined by sequencing, but these methods require tissue dissociation, which loses the location, and surrounding environmental cues, of tumor-infiltrating B/PC clones. Discovering the B/PC ‘clonal niche’ could identify key factors that determine to what, where, and how B/PC clones respond, and harness these to boost anti-tumor immunity. We recently developed a spatial transcriptomics-based technology (Spatial VDJ) and the associated computational pipelines to capture and reconstruct full-length BCRs directly in their native tissues. Here, I propose to use Spatial VDJ, along with other state-of-the-art methods, to link tumor-associated B/PC clones to their molecular and cellular environment with the ultimate goal to provide new immunotherapy strategies.

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