Camilla Björkegren

Camilla Björkegren

Professor | Prefekt
Telefon: +46852482928
Besöksadress: Solnavägen 9, 17165 Stockholm
Postadress: C5 Cell- och molekylärbiologi, C5 CMB Björkegren, 171 77 Stockholm
Del av:

Om mig

  • Professor i cell- och tumörbiologi

Utvalda publikationer

Artiklar

Alla övriga publikationer

Forskningsbidrag

  • Swedish Research Council
    1 January 2024 - 31 December 2027
    Cellular function requires a multitude of proteins and co-factors that allow chromosomal DNA to be properly transcribed, duplicated, repaired, and segregated. In turn, these processes depend on the three-dimensional (3D) folding of chromosomes, and are influenced by changes in the helical structure of DNA, so-called supercoiling. We and others have suggested that supercoiling is functionally connected to chromosome 3D organization, but direct evidence has been lacking. Collectively, our investigations now show that a family of chromosome-folding machines, called Structural Maintenance of Chromosome protein complexes, indeed link supercoiling to chromosome 3D organization (e.g., Nature 2011, Cell Rep. 2015, Science Adv. 2022, Nature 2023). The purpose of the presented project is to determine how this mostly unknown interplay contributes to chromosome function. The specific aims are to:1)  Establish the molecular mechanisms of the DNA supercoiling-chromosome folding interplay.2) Determine how the supercoiling-folding interplay influence transcription and early development.This will be achieved by combining a variety of methods such as high-resolution micro-C analysis, single molecule analysis, high resolution microscopy, various in vivo models, and a unique marker for DNA supercoiling that we recently discovered. This will unravel new fundamental principles of chromosome organization and provide insights into the cellular defence against disease-related chromosomal aberrations.
  • The DNA double helix in health and disease. Analysis of how supercoiling affects chromosome folding and stability.
    Cancerfonden
    1 January 2023 - 31 December 2025

Anställningar

  • Professor, Cell- och molekylärbiologi, Karolinska Institutet, 2010-

Uppdrag

  • Prefekt, Cell- och molekylärbiologi, Karolinska Institutet, 2024-

Nyheter från KI

Kalenderhändelser från KI