Camilla Björkegren
Professor | Prefekt
E-postadress: camilla.bjorkegren@ki.se
Telefon: +46852482928
Besöksadress: Solnavägen 9, 17165 Stockholm
Postadress: C5 Cell- och molekylärbiologi, C5 CMB Björkegren, 171 77 Stockholm
Del av:
- Institutionen för cell- och molekylärbiologi
- Camilla Björkegrens grupp
Om mig
- Professor i cell- och tumörbiologi
Utvalda publikationer
- Article: MOLECULAR CELL. 2024;84(5):867-882.e5Jeppsson K; Pradhan B; Sutani T; Sakata T; Igarashi MU; Berta DG; Kanno T; Nakato R; Shirahige K; Kim E; Bjorkegren C
Artiklar
- Article: NATURE COMMUNICATIONS. 2024;15(1):1454Sanyal S; Kouznetsova A; Strom L; Bjorkegren C
- Article: NATURE. 2023;616(7958):843-848Pradhan B; Kanno T; Igarashi MU; Loke MS; Baaske MD; Wong JSK; Jeppsson K; Bjorkegren C; Kim E
- Article: SCIENCE ADVANCES. 2022;8(23):eabn7063Jeppsson K; Sakata T; Nakato R; Milanova S; Shirahige K; Bjorkegren C
- Article: NATURE COMMUNICATIONS. 2020;11(1):138Sen I; Zhou X; Chernobrovkin A; Puerta-Cavanzo N; Kanno T; Salignon J; Stoehr A; Lin X-X; Baskaner B; Brandenburg S; Bjorkegren C; Zubarev RA; Riedel CG
- Article: NATURE COMMUNICATIONS. 2018;9(1):3785Karlberg T; Hornyak P; Pinto AF; Milanova S; Ebrahimi M; Lindberg M; Pullen N; Nordstrom A; Loverli E; Caraballo R; Wong EV; Nareoja K; Thorsell A-G; Elofsson M; De la Cruz EM; Bjorkegren C; Schuler H
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2018;19(3):E884-884Bjorkegren C; Baranello L
- Article: STRUCTURE. 2016;24(5):789-796Kouznetsova E; Kanno T; Karlberg T; Thorsell A-G; Wisniewska M; Kursula P; Sjogren C; Schuler H
- Article: CELL REPORTS. 2015;12(9):1471-1482Kanno T; Berta DG; Sjogren C
- Article: DNA REPAIR. 2015;28:83-92Carlborg KK; Kanno T; Carter SD; Sjogren C
- Article: PLOS GENETICS. 2014;10(10):e1004680Jeppsson K; Carlborg KK; Nakato R; Berta DG; Lilienthal I; Kanno T; Lindqvist A; Brink MC; Dantuma NP; Katou Y; Shirahige K; Sjogren C
- Article: PLOS GENETICS. 2013;9(11):e1003898Lilienthal I; Kanno T; Sjogren C
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(14):11374-11383Bustard DE; Menolfi D; Jeppsson K; Ball LG; Dewey SC; Shirahige K; Sjogren C; Branzei D; Cobb JA
- Article: JOURNAL OF CELL SCIENCE. 2011;124(16):2735-2742Guerra L; Guidi R; Slot I; Callegari S; Sompallae R; Pickett CL; Astrom S; Eisele F; Wolf D; Sjogren C; Masucci MG; Frisan T
- Article: NATURE. 2011;471(7338):392-396Kegel A; Betts-Lindroos H; Kanno T; Jeppsson K; Strom L; Katou Y; Itoh T; Shirahige K; Sjogren C
- Article: SCIENCE. 2007;317(5835):242-245Stroem L; Karlsson C; Betts Lindroos H; Wedahl S; Katou Y; Shirahige K; Sjoegren C
- Article: CURRENT OPINION IN CELL BIOLOGY. 2007;19(3):344-349Strom L; Sjogren C
- Article: MOLECULAR CELL. 2006;22(6):755-767Lindroos HB; Ström L; Itoh T; Katou Y; Shirahige K; Sjögren C
- Article: MOLECULAR CELL. 2004;16(6):1003-1015Ström L; Lindroos HB; Shirahige K; Sjögren C
- Article: CURRENT BIOLOGY. 2001;11(12):991-995Sjögren C; Nasmyth K
- Article: BIOCHEMISTRY. 1998;37(26):9274-9283Korenbaum E; Nordberg P; Björkegren-Sjögren C; Schutt CE; Lindberg U; Karlsson R
- Article: FEBS LETTERS. 1997;418(3):258-264BjorkegrenSjogren C; Korenbaum E; Nordberg P; Lindberg U; Karlsson R
- Article: EXPERIMENTAL CELL RESEARCH. 1997;234(1):66-77Hajkova L; Sjogren CB; Korenbaum E; Nordberg P; Karlsson R
- Journal article: FEBS LETTERS. 1993;333(1-2):123-126BJORKEGREN C; ROZYCKI M; SCHUTT CE; LINDBERG U; KARLSSON R
- Journal article: AIDS. 1990;4(4):291-295ALBERT J; NAUCLER A; BOTTIGER B; BROLIDEN PA; ALBINO P; OUATTARA SA; BJORKEGREN C; VALENTIN A; BIBERFELD G; FENYO EM
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Alla övriga publikationer
- Preprint: BIORXIV. 2024;BIORXIVPradhan B; Pinto A; Kanno T; Tetiker D; Baaske MD; Cutt E; Chatzicharlampous C; Schüler H; Deep A; Corbett KD; Aragon L; Virnau P; Björkegren C; Kim E
- Preprint: BIORXIV. 2023Jeppsson K; Pradhan B; Sutani T; Sakata T; Igarashi MU; Berta DG; Kanno T; Nakato R; Shirahige K; Kim E; Björkegren C
- Preprint: BIORXIV. 2022Sanyal S; Kouznetsova A; Björkegren C
- Editorial comment: EMBO JOURNAL. 2016;35(7):703-705Schuler H; Sjogren C
- Editorial comment: EXPERIMENTAL CELL RESEARCH. 2014;329(1):1Sjogren C; Tarsounas M; Bartek J; Hoog C
- Review: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2014;15(9):601-614Jeppsson K; Kanno T; Shirahige K; Sjogren C
- Editorial comment: NATURE REVIEWS MOLECULAR CELL BIOLOGY. 2012;13(5):282Sjogren C
- Review: CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2012;47(1):1-16Carter SD; Sjogren C
- Review: EXPERIMENTAL CELL RESEARCH. 2010;316(9):1445-1453Sjogren C; Strom L
- Review: COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY. 2010;75:179-187Kegel A; Sjögren C
Forskningsbidrag
- Swedish Research Council1 January 2024 - 31 December 2027Cellular function requires a multitude of proteins and co-factors that allow chromosomal DNA to be properly transcribed, duplicated, repaired, and segregated. In turn, these processes depend on the three-dimensional (3D) folding of chromosomes, and are influenced by changes in the helical structure of DNA, so-called supercoiling. We and others have suggested that supercoiling is functionally connected to chromosome 3D organization, but direct evidence has been lacking. Collectively, our investigations now show that a family of chromosome-folding machines, called Structural Maintenance of Chromosome protein complexes, indeed link supercoiling to chromosome 3D organization (e.g., Nature 2011, Cell Rep. 2015, Science Adv. 2022, Nature 2023). The purpose of the presented project is to determine how this mostly unknown interplay contributes to chromosome function. The specific aims are to:1) Establish the molecular mechanisms of the DNA supercoiling-chromosome folding interplay.2) Determine how the supercoiling-folding interplay influence transcription and early development.This will be achieved by combining a variety of methods such as high-resolution micro-C analysis, single molecule analysis, high resolution microscopy, various in vivo models, and a unique marker for DNA supercoiling that we recently discovered. This will unravel new fundamental principles of chromosome organization and provide insights into the cellular defence against disease-related chromosomal aberrations.
- The DNA double helix in health and disease. Analysis of how supercoiling affects chromosome folding and stability.Cancerfonden1 January 2023 - 31 December 2025
Anställningar
- Professor, Cell- och molekylärbiologi, Karolinska Institutet, 2010-
Uppdrag
- Prefekt, Cell- och molekylärbiologi, Karolinska Institutet, 2024-