Brennan Wadsworth

Publikationer
Forskningsbidrag
Populärvetenskap och samverkan

Artiklar

Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2025;117(7):1410-1420
Antihypertensive drugs and survival outcomes in oropharyngeal squamous cell carcinoma patients
Lee C-M; Wadsworth BJ; Urban R; Clark MA; Shi R; Sit D; Hamilton SN; Bennewith KL
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2025;14(6):e70037
Functional characterisation of CD8+ T cells mobilised with acute supramaximal high‐intensity interval exercise: implications for immune surveillance
Strömberg A; Mandić M; Wadsworth BJ; Proschinger S; Alam S; Eriksson LMJ; Barbieri L; Rullman E; Rundqvist H
Journal article: ELIFE. 2024;12
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: ELIFE. 2024;12:rp92707
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Journal article: CANCERS. 2024;16(12):2215
Relating Macroscopic PET Radiomics Features to Microscopic Tumor Phenotypes Using a Stochastic Mathematical Model of Cellular Metabolism and Proliferation
Ahn HSH; Oloumi Yazdi Y; Wadsworth BJ; Bennewith KL; Rahmim A; Klyuzhin IS
Article: NATURE METABOLISM. 2023;5(10):1747-1764
Glutarate regulates T cell metabolism and anti-tumour immunity
Minogue E; Cunha PP; Wadsworth BJ; Grice GL; Sah-Teli SK; Hughes R; Bargiela D; Quaranta A; Zurita J; Antrobus R; Velica P; Barbieri L; Wheelock CE; Koivunen P; Nathan JA; Foskolou IP; Johnson RS
Article: ELIFE. 2023;12:e84280
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha PP; Minogue E; Krause LCM; Hess RM; Bargiela D; Wadsworth BJ; Barbieri L; Brombach C; Foskolou IP; Bogeski I; Velica P; Johnson RS
Journal article: FRONTIERS IN ONCOLOGY. 2022;12:841921
Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth
Cederberg RA; Franks SE; Wadsworth BJ; So A; Decotret LR; Hall MG; Shi R; Hughes MR; McNagny KM; Bennewith KL
Journal article: BRITISH JOURNAL OF CANCER. 2022;126(11):1616-1626
Transiently hypoxic tumour cell turnover and radiation sensitivity in human tumour xenografts
Wadsworth BJ; Lee C-M; Bennewith KL
Journal article: ONCOIMMUNOLOGY. 2022;11(1):2010905
CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development
Melese ES; Franks E; Cederberg RA; Harbourne BT; Shi R; Wadsworth BJ; Collier JL; Halvorsen EC; Johnson F; Luu J; Oh MH; Lam V; Krystal G; Hoover SB; Raffeld M; Simpson RM; Unni AM; Lam WL; Lam S; Abraham N; Bennewith KL; Lockwood WW
Journal article: ACTA ONCOLOGICA. 2021;60(11):1489-1498
Evaluation of ¹⁸F-EF5 for detection of hypoxia in localized adenocarcinoma of the prostate
Wadsworth BJ; Decotret LR; Villamil C; Yapp D; Wilson D; Benard F; McKenzie M; Bennewith KL
Journal article: CLINICAL CANCER RESEARCH. 2021;27(8_Supplement):po-034-po-034
Abstract PO-034: Changes in cancer associated fibroblast subsets following angiotensin II type I receptor blocker (ARB) treatment reduces transient hypoxia and radiation resistance
Lee C-M; Wadsworth BJ; Bennewith KL
Journal article: MOLECULAR BIOLOGY OF THE CELL. 2021;32(7):567-578
Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion
Decotret LR; Wadsworth BJ; Li LV; Lim CJ; Bennewith KL; Pallen CJ
Journal article: ONCOIMMUNOLOGY. 2021;10(1):1959978
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer
Firmino NS; Cederberg RA; Lee C-M; Shi R; Wadsworth BJ; Franks SE; Thomas KN; Decotret LR; Bennewith KL
Journal article: CANCER LETTERS. 2020;493:31-40
Angiotensin II type 1 receptor blocker telmisartan inhibits the development of transient hypoxia and improves tumour response to radiation
Wadsworth BJ; Cederberg RA; Lee C-M; Firmino NS; Franks SE; Pan J; Colpo N; Lin K-S; Benard F; Bennewith KL
Journal article: CANCER IMMUNOLOGY RESEARCH. 2020;8(4_Supplement):a50
Abstract A50: Interleukin-33 increases ST2+ regulatory T cells and promotes metastatic tumor growth in the lungs in an amphiregulin-dependent manner
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Journal article: ALZHEIMERS RESEARCH & THERAPY. 2019;11(1):44
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice
Button EB; Boyce GK; Wilkinson A; Stukas S; Hayat A; Fan J; Wadsworth BJ; Robert J; Martens KM; Wellington CL
Article: ONCOIMMUNOLOGY. 2019;8(2):e1527497
IL-33 increases ST2⁺ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Journal article: SCIENTIFIC REPORTS. 2018;8(1):152
Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours
Martinez VD; Firmino NS; Marshall EA; Ng KW; Wadsworth BJ; Anderson C; Lam WL; Bennewith KL
Journal article: JOURNAL OF NUCLEAR MEDICINE. 2017;58(5):815-820
2-¹⁸F-Fluoroethanol Is a PET Reporter of Solid Tumor Perfusion
Wadsworth BJ; Pan J; Dude I; Colpo N; Bosiljcic M; Lin K-S; Benard F; Bennewith KL
Journal article: ONCOIMMUNOLOGY. 2016;5(6):e1150398
Maraviroc decreases CCL8-mediated migration of CCR5⁺ regulatory T cells and reduces metastatic tumor growth in the lungs
Halvorsen EC; Hamilton MJ; Young A; Wadsworth BJ; LePard NE; Lee HN; Firmino N; Collier JL; Bennewith KL
Journal article: DISEASE MODELS & MECHANISMS. 2015;8(8):999-1009
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype
Fajardo VA; Bombardier E; McMillan E; Tran K; Wadsworth BJ; Gamu D; Hopf A; Vigna C; Smith IC; Bellissimo C; Michel RN; Tarnopolsky MA; Quadrilatero J; Tupling AR
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Alla övriga publikationer

Conference publication: CLINICAL CANCER RESEARCH. 2025;31(2):b016
Targeting the angiotensin receptor in cancer-associated fibroblasts improves tumour perfusion, oxygenation, and radiotherapy response
Lee C-M; Wadsworth BJ; Cederberg RA; Li ZH; Thomas KN; Clark M; Shi R; Hall M; Telkar N; Urban R; Lam WL; Hamilton SN; Bennewith KL
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Preprint: BIORXIV. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth B; Leiwe M; Minogue E; Cunha P; Engman V; Brombach C; Asvestis C; Sah-Teli S; Marklund E; Koivunen P; Ruas J; Rundqvist H; Lanner J; Johnson R
Preprint: BIORXIV. 2022
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha P; Minogue E; Krause L; Hess R; Bargiela D; Wadsworth B; Barbieri L; Brombach C; Foskolou I; Bogeski I; Veliça P; Johnson R
Preprint: BIORXIV. 2022
Glutarate regulates T cell function and metabolism
Minogue E; Cunha P; Quaranta A; Zurita J; Teli SS; Wadsworth B; Hughes R; Grice G; Velica P; Bargiela D; Barbieri L; Wheelock C; Nathan J; Koivunen P; Foskolou I; Johnson R
Conference publication: CLINICAL CANCER RESEARCH. 2021;27(8)
Changes in cancer associated fibroblast subsets following angiotensin II type I receptor blocker (ARB) treatment reduces transient hypoxia and radiation resistance.
Lee C-M; Wadsworth BJ; Bennewith KL
Conference publication: CLINICAL CANCER RESEARCH. 2021;27(8)
Angiotensin II receptor blockers modify the solid tumor microenvironment and improve radiation therapy response.
Wadsworth BJ; Lee C-M; Urban R; Hamilton SN; Bennewith KL
Conference publication: CANCER RESEARCH. 2020;80(21)
The angiotensin II type 1 receptor blocker telmisartan inhibits the development of transient tumour hypoxia and improves response to ionizing radiation therapy.
Wadsworth BJ; Cederberg RA; Lee C-M; Firmino NS; Franks SE; Pan J; Colpo N; Lin K-S; Benard F; Bennewith KL
Conference publication: CANCER IMMUNOLOGY RESEARCH. 2020;8(4):62-63
Interleukin-33 increases ST2+regulatory T cells and promotes metastatic tumor growth in the lungs in an amphiregulin-dependent manner.
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Conference publication: CANCER IMMUNOLOGY RESEARCH. 2020;8(4):72-73
The role of eosinophils in the lung tumor microenvironment.
Cederberg RA; So A; Franks E; Collier J; Wadsworth BJ; Hughes MR; McNagny KM; Bennewith KL
Conference publication: JOURNAL OF IMMUNOLOGY. 2015;194
CCR5⁺ regulatory T cells induced by metastatic breast carcinomas migrate toward a gradient of CCL8 and accumulate in metastatic lung tissue
Halvorsen E; Hamilton M; LePard N; Bosiljcic M; Young A; Wadsworth B; Bennewith K

Forskningsbidrag

Metabolic and epigenetic regulation of cancer associated fibroblasts by angiotensin II
Canadian Institutes of Health Research
1 June 2021 - 31 August 2024
Metabolic and epigenetic regulation of cancer associated fibroblasts by angiotensin II
Canadian Institutes of Health Research
1 June 2021 - 31 May 2025

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