Brennan Wadsworth

About me
Publications
Grants
Public outreach and news

About me

A postdoctoral fellow in the laboratory of Dr. Randall S. Johnson, Brennan
has been investigating the role of metabolism in the regulation of skeletal muscle and immune cell physiology.

Born in Ontario, Brennan conducted his PhD training at the University of British Columbia in Vancouver, Canada, in the laboratory of Dr. Kevin L. Bennewith, investigating the mechanisms of vascular dysfunction in solid tumours.

Articles

Journal article: JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE. 2025;:djaf056
Antihypertensive drugs and survival outcomes in oropharyngeal squamous cell carcinoma patients
Lee C-M; Wadsworth BJ; Urban R; Clark MA; Shi R; Sit D; Hamilton SN; Bennewith KL
Journal article: ELIFE. 2024;12
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Article: ELIFE. 2024;12:rp92707
A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Karppinen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Journal article: CANCERS. 2024;16(12):2215
Relating Macroscopic PET Radiomics Features to Microscopic Tumor Phenotypes Using a Stochastic Mathematical Model of Cellular Metabolism and Proliferation
Ahn HSH; Oloumi Yazdi Y; Wadsworth BJ; Bennewith KL; Rahmim A; Klyuzhin IS
Article: NATURE METABOLISM. 2023;5(10):1747-1764
Glutarate regulates T cell metabolism and anti-tumour immunity
Minogue E; Cunha PP; Wadsworth BJ; Grice GL; Sah-Teli SK; Hughes R; Bargiela D; Quaranta A; Zurita J; Antrobus R; Velica P; Barbieri L; Wheelock CE; Koivunen P; Nathan JA; Foskolou IP; Johnson RS
Article: ELIFE. 2023;12:e84280
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha PP; Minogue E; Krause LCM; Hess RM; Bargiela D; Wadsworth BJ; Barbieri L; Brombach C; Foskolou IP; Bogeski I; Velica P; Johnson RS
Journal article: ONCOIMMUNOLOGY. 2022;11(1):2010905
CCL5 production in lung cancer cells leads to an altered immune microenvironment and promotes tumor development
Melese ES; Franks E; Cederberg RA; Harbourne BT; Shi R; Wadsworth BJ; Collier JL; Halvorsen EC; Johnson F; Luu J; Oh MH; Lam V; Krystal G; Hoover SB; Raffeld M; Simpson RM; Unni AM; Lam WL; Lam S; Abraham N; Bennewith KL; Lockwood WW
Journal article: BRITISH JOURNAL OF CANCER. 2022;126(11):1616-1626
Transiently hypoxic tumour cell turnover and radiation sensitivity in human tumour xenografts
Wadsworth BJ; Lee C-M; Bennewith KL
Journal article: FRONTIERS IN ONCOLOGY. 2022;12:841921
Eosinophils Decrease Pulmonary Metastatic Mammary Tumor Growth
Cederberg RA; Franks SE; Wadsworth BJ; So A; Decotret LR; Hall MG; Shi R; Hughes MR; McNagny KM; Bennewith KL
Journal article: ACTA ONCOLOGICA. 2021;60(11):1489-1498
Evaluation of ¹⁸F-EF5 for detection of hypoxia in localized adenocarcinoma of the prostate
Wadsworth BJ; Decotret LR; Villamil C; Yapp D; Wilson D; Benard F; McKenzie M; Bennewith KL
Journal article: CLINICAL CANCER RESEARCH. 2021;27(8_Supplement):po-034-po-034
Abstract PO-034: Changes in cancer associated fibroblast subsets following angiotensin II type I receptor blocker (ARB) treatment reduces transient hypoxia and radiation resistance
Lee C-M; Wadsworth BJ; Bennewith KL
Journal article: MOLECULAR BIOLOGY OF THE CELL. 2021;32(7):567-578
Receptor-type protein tyrosine phosphatase alpha (PTPα) mediates MMP14 localization and facilitates triple-negative breast cancer cell invasion
Decotret LR; Wadsworth BJ; Li LV; Lim CJ; Bennewith KL; Pallen CJ
Journal article: ONCOIMMUNOLOGY. 2021;10(1):1959978
Germinal center hypoxia in tumor-draining lymph nodes negatively regulates tumor-induced humoral immune responses in mouse models of breast cancer
Firmino NS; Cederberg RA; Lee C-M; Shi R; Wadsworth BJ; Franks SE; Thomas KN; Decotret LR; Bennewith KL
Journal article: CANCER LETTERS. 2020;493:31-40
Angiotensin II type 1 receptor blocker telmisartan inhibits the development of transient hypoxia and improves tumour response to radiation
Wadsworth BJ; Cederberg RA; Lee C-M; Firmino NS; Franks SE; Pan J; Colpo N; Lin K-S; Benard F; Bennewith KL
Journal article: CANCER IMMUNOLOGY RESEARCH. 2020;8(4_Supplement):a50
Abstract A50: Interleukin-33 increases ST2+ regulatory T cells and promotes metastatic tumor growth in the lungs in an amphiregulin-dependent manner
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Journal article: ALZHEIMERS RESEARCH & THERAPY. 2019;11(1):44
ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice
Button EB; Boyce GK; Wilkinson A; Stukas S; Hayat A; Fan J; Wadsworth BJ; Robert J; Martens KM; Wellington CL
Article: ONCOIMMUNOLOGY. 2019;8(2):e1527497
IL-33 increases ST2⁺ Tregs and promotes metastatic tumour growth in the lungs in an amphiregulin-dependent manner
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Journal article: SCIENTIFIC REPORTS. 2018;8(1):152
Non-coding RNAs predict recurrence-free survival of patients with hypoxic tumours
Martinez VD; Firmino NS; Marshall EA; Ng KW; Wadsworth BJ; Anderson C; Lam WL; Bennewith KL
Journal article: JOURNAL OF NUCLEAR MEDICINE. 2017;58(5):815-820
2-¹⁸F-Fluoroethanol Is a PET Reporter of Solid Tumor Perfusion
Wadsworth BJ; Pan J; Dude I; Colpo N; Bosiljcic M; Lin K-S; Benard F; Bennewith KL
Journal article: ONCOIMMUNOLOGY. 2016;5(6):e1150398
Maraviroc decreases CCL8-mediated migration of CCR5⁺ regulatory T cells and reduces metastatic tumor growth in the lungs
Halvorsen EC; Hamilton MJ; Young A; Wadsworth BJ; LePard NE; Lee HN; Firmino N; Collier JL; Bennewith KL
Journal article: DISEASE MODELS & MECHANISMS. 2015;8(8):999-1009
Phospholamban overexpression in mice causes a centronuclear myopathy-like phenotype
Fajardo VA; Bombardier E; McMillan E; Tran K; Wadsworth BJ; Gamu D; Hopf A; Vigna C; Smith IC; Bellissimo C; Michel RN; Tarnopolsky MA; Quadrilatero J; Tupling AR
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All other publications

Conference publication: CLINICAL CANCER RESEARCH. 2025;31(2):b016
Targeting the angiotensin receptor in cancer-associated fibroblasts improves tumour perfusion, oxygenation, and radiotherapy response
Lee C-M; Wadsworth BJ; Cederberg RA; Li ZH; Thomas KN; Clark M; Shi R; Hall M; Telkar N; Urban R; Lam WL; Hamilton SN; Bennewith KL
Preprint: ELIFE SCIENCES PUBLICATIONS, LTD. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth BJ; Leiwe M; Minogue EA; Cunha PP; Engman V; Brombach C; Asvestis C; Sah-Teli SK; Marklund E; Koivunen P; Ruas JL; Rundqvist H; Lanner JT; Johnson RS
Preprint: BIORXIV. 2023
A 2-Hydroxybutyrate- mediated feedback loop regulates muscular fatigue
Wadsworth B; Leiwe M; Minogue E; Cunha P; Engman V; Brombach C; Asvestis C; Sah-Teli S; Marklund E; Koivunen P; Ruas J; Rundqvist H; Lanner J; Johnson R
Preprint: BIORXIV. 2022
Oxygen levels at the time of activation determine T cell persistence and immunotherapeutic efficacy
Cunha P; Minogue E; Krause L; Hess R; Bargiela D; Wadsworth B; Barbieri L; Brombach C; Foskolou I; Bogeski I; Veliça P; Johnson R
Preprint: BIORXIV. 2022
Glutarate regulates T cell function and metabolism
Minogue E; Cunha P; Quaranta A; Zurita J; Teli SS; Wadsworth B; Hughes R; Grice G; Velica P; Bargiela D; Barbieri L; Wheelock C; Nathan J; Koivunen P; Foskolou I; Johnson R
Conference publication: CLINICAL CANCER RESEARCH. 2021;27(8)
Changes in cancer associated fibroblast subsets following angiotensin II type I receptor blocker (ARB) treatment reduces transient hypoxia and radiation resistance.
Lee C-M; Wadsworth BJ; Bennewith KL
Conference publication: CLINICAL CANCER RESEARCH. 2021;27(8)
Angiotensin II receptor blockers modify the solid tumor microenvironment and improve radiation therapy response.
Wadsworth BJ; Lee C-M; Urban R; Hamilton SN; Bennewith KL
Conference publication: CANCER RESEARCH. 2020;80(21)
The angiotensin II type 1 receptor blocker telmisartan inhibits the development of transient tumour hypoxia and improves response to ionizing radiation therapy.
Wadsworth BJ; Cederberg RA; Lee C-M; Firmino NS; Franks SE; Pan J; Colpo N; Lin K-S; Benard F; Bennewith KL
Conference publication: CANCER IMMUNOLOGY RESEARCH. 2020;8(4):62-63
Interleukin-33 increases ST2+regulatory T cells and promotes metastatic tumor growth in the lungs in an amphiregulin-dependent manner.
Halvorsen EC; Franks SE; Wadsworth BJ; Harbourne BT; Cederberg RA; Steer CA; Martinez-Gonzalez I; Calder J; Lockwood WW; Bennewith KL
Conference publication: CANCER IMMUNOLOGY RESEARCH. 2020;8(4):72-73
The role of eosinophils in the lung tumor microenvironment.
Cederberg RA; So A; Franks E; Collier J; Wadsworth BJ; Hughes MR; McNagny KM; Bennewith KL
Conference publication: JOURNAL OF IMMUNOLOGY. 2015;194
CCR5⁺ regulatory T cells induced by metastatic breast carcinomas migrate toward a gradient of CCL8 and accumulate in metastatic lung tissue
Halvorsen E; Hamilton M; LePard N; Bosiljcic M; Young A; Wadsworth B; Bennewith K

Grants

Metabolic and epigenetic regulation of cancer associated fibroblasts by angiotensin II
Canadian Institutes of Health Research
1 June 2021 - 31 August 2024
Metabolic and epigenetic regulation of cancer associated fibroblasts by angiotensin II
Canadian Institutes of Health Research
1 June 2021 - 31 May 2025

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