Boris Zhivotovsky

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Journal article: BIOLOGY DIRECT. 2025;20(1):78
Prognostic model integrating histology, systemic inflammation, and recurrence status predicts immunotherapy response in advanced non-small-cell lung cancer patients
Moiseenko FV; Krasavina MA; Agranov IR; Artemieva EV; Oganesian AP; Gabina AS; Makarkina ML; Elsakova EO; Henshtein VA; Volkov NM; Egorenkov VV; Moiseenko VM; Fedyanin MY; Kopeina GS; Zhivotovsky B; Zamaraev AV
Journal article: TRENDS IN CELL BIOLOGY. 2025;:S0962-8924(25)00146-1
Mitochondrial DNA: how does it leave mitochondria?
Gogvadze V; Zhivotovsky B
Article: CELL DEATH DISCOVERY. 2025;11(1):34
The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells
Zhao Y; Dhani S; Gogvadze V; Zhivotovsky B
Article: ACS APPLIED MATERIALS & INTERFACES. 2025;17(1):374-385
Amphiphilic Photoluminescent Porous Silicon Nanoparticles as Effective Agents for Ultrasound-Amplified Cancer Therapy
Gongalsky MB; Tsurikova UA; Kudryavtsev AA; Pervushin NV; Sviridov AP; Kumeria T; Egoshina VD; Tyurin-Kuzmin PA; Naydov IA; Gonchar KA; Kopeina GS; Andreev VG; Zhivotovsky B; Osminkina LA
Article: APOPTOSIS. 2024;29(11-12):2197-2213
BH3-mimetics or DNA-damaging agents in combination with RG7388 overcome p53 mutation-induced resistance to MDM2 inhibition
Pervushin NV; Nilov DK; Pushkarev SV; Shipunova VO; Badlaeva AS; Yapryntseva MA; Kopytova DV; Zhivotovsky B; Kopeina GS
Article: CELL DEATH & DISEASE. 2024;15(11):827
Ally or traitor: the dual role of p62 in caspase-2 regulation
Volik PI; Zamaraev AV; Egorshina AY; Pervushin NV; Kapusta AA; Tyurin-Kuzmin PA; Lipatova AV; Kaehne T; Lavrik IN; Zhivotovsky B; Kopeina GS
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2024;1870(7):167317
Permeabilization of the outer mitochondrial membrane: Mechanisms and consequences
Yapryntseva MA; Zhivotovsky B; Gogvadze V
Article: BIOLOGY DIRECT. 2024;19(1):58
Features of the CD1 gene family in rodents and the uniqueness of the immune system of naked mole-rat
Gunbin KV; Kopeina GS; Zhivotovsky B; Zamaraev AV
Article: CELLS. 2024;13(5):388
Cancer Drug Resistance: Targeting Proliferation or Programmed Cell Death
Sazonova EV; Yapryntseva MA; Pervushin NV; Tsvetcov RI; Zhivotovsky B; Kopeina GS
Article: CELL DEATH DISCOVERY. 2023;9(1):352
Prognostic signature based on mitochondria quality control proteins for the prediction of lung adenocarcinoma patients survival
Gorbunova AS; Zamaraev AV; Yapryntseva MA; Kovaleva OV; Tchevkina EM; Turkina MV; Zhivotovsky B; Kopeina GS
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2022;633:55-58
Programmed cell death: Past, present and future
Kopeina GS; Zhivotovsky B
Article: CELL DEATH DISCOVERY. 2022;8(1):417
Drug toxicity assessment: cell proliferation versus cell death
Sazonova EV; Chesnokov MS; Zhivotovsky B; Kopeina GS
Article: JOVE-JOURNAL OF VISUALIZED EXPERIMENTS. 2022;(188)
Exploring Caspase Mutations and Post-Translational Modification by Molecular Modeling Approaches
Nilov DK; Zamaraev AV; Zhivotovsky B; Kopeina GS
Article: ACS BIOMATERIALS SCIENCE & ENGINEERING. 2022;8(10):4185-4195
Nonresonant CARS Imaging of Porous and Solid Silicon Nanoparticles in Human Cells
Gongalsky MB; Muftieva DA; Saarinen JKS; Isomaki A; V. Pervushin N; Kopeina GS; Peltonen LJ; Strachan CJ; Zhivotovsky B; Santos HA; Osminkina LA
Article: CELL DEATH DISCOVERY. 2022;8(1):284
Caspase-2 is a mediator of apoptotic signaling in response to gemtuzumab ozogamicin in acute myeloid leukemia
Haag P; Olsson M; Forsberg J; Lindberg ML; Stenerlow B; Zong D; Kanter L; Lewensohn R; Viktorsson K; Zhivotovsky B; Stenke L
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(7):3733
Necroptosis as a Novel Facet of Mitotic Catastrophe
Egorshina AY; Zamaraev AV; Kaminskyy VO; Radygina TV; Zhivotovsky B; Kopeina GS
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:227-239
Induction and Detection of Mitophagy.
Yapryntseva MA; Zhivotovsky B; Gogvadze V
Article: METHODS IN MOLECULAR BIOLOGY. 2022;2445:3-24
A Balance Between Autophagy and Other Cell Death Modalities in Cancer.
Gorbunova AS; Kopeina GS; Zhivotovsky B
Article: CANCERS. 2021;14(1):181
Bak and Bcl-xL Participate in Regulating Sensitivity of Solid Tumor Derived Cell Lines to Mcl-1 Inhibitors
Senichkin VV; Pervushin NV; Zamaraev AV; Sazonova EV; Zuev AP; Streletskaia AY; Prikazchikova TA; Zatsepin TS; Kovaleva OV; Tchevkina EM; Zhivotovsky B; Kopeina GS
Article: NANOMATERIALS. 2021;11(9):2167
Optical Monitoring of the Biodegradation of Porous and Solid Silicon Nanoparticles
Gongalsky MB; Pervushin NV; Maksutova DE; Tsurikova UA; Putintsev PP; Gyuppenen OD; Evstratova YV; Shalygina OA; Kopeina GS; Kudryavtsev AA; Zhivotovsky B; Osminkina LA
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2021;345:109553
Modeling hypoxia facilitates cancer cell survival through downregulation of p53 expression
Zhang Y; Yapryntseva MA; Vdovin A; Maximchik P; Zhivotovsky B; Gogvadze V
Article: CANCERS. 2021;13(16):4027
Receptor-Mediated Mitophagy Rescues Cancer Cells under Hypoxic Conditions
Abdrakhmanov A; Yapryntseva MA; Kaminskyy VO; Zhivotovsky B; Gogvadze V
Article: CELLS. 2021;10(4):852
Simple and Efficient Protocol for Subcellular Fractionation of Normal and Apoptotic Cells
Senichkin VV; Prokhorova EA; Zhivotovsky B; Kopeina GS
Article: METHODS IN MOLECULAR BIOLOGY. 2021;2276:215-225
Analysis of Mitochondrial Dysfunction During Cell Death.
Gogvadze V; Zhivotovsky B
Article: CELL DEATH & DISEASE. 2020;11(10):825
Requirement for Serine-384 in Caspase-2 processing and activity
Zamaraev AV; Volik PI; Nilov DK; Turkina MV; Egorshina AY; Gorbunova AS; Iarovenko SI; Zhivotovsky B; Kopeina GS
Article: BIOCHEMISTRY-MOSCOW. 2020;85(10):1235-1244
Nutrient Deprivation Promotes MCL-1 Degradation in an Autophagy-Independent Manner
Pervushin NV; Senichkin VV; Kapusta AA; Gorbunova AS; Kaminskyy VO; Zhivotovsky B; Kopeina GS
Article: BIOCHEMISTRY-MOSCOW. 2020;85(10):1245-1253
BNIP3 as a Regulator of Cisplatin-Induced Apoptosis
Gorbunova AS; Denisenko TV; Yapryntseva MA; Pivnyuk AD; Prikazchikova TA; Gogvadze VG; Zhivotovsky B
Article: FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY. 2020;8:543066
Upregulation of Mcl-1S Causes Cell-Cycle Perturbations and DNA Damage Accumulation
Streletskaia AY; Senichkin VV; Prikazchikova TA; Zatsepin TS; Zhivotovsky B; Kopeina GS
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE. 2020;1866(6):165745
Desmin mutations result in mitochondrial dysfunction regardless of their aggregation properties
Smolina N; Khudiakov A; Knyazeva A; Zlotina A; Sukhareva K; Kondratov K; Gogvadze V; Zhivotovsky B; Sejersen T; Kostareva A
Article: CANCERS. 2020;12(4):E990-990
Comprehensive Map of the Regulated Cell Death Signaling Network: A Powerful Analytical Tool for Studying Diseases
Ravel J-M; Gomez LCM; Sompairac N; Calzone L; Zhivotovsky B; Kroemer G; Barillot E; Zinovyev A; Kuperstein I
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2020;77(6):1197-1207
Distinct effects of etoposide on glutamine-addicted neuroblastoma
Valter K; Maximchik P; Abdrakhmanov A; Senichkin V; Zhivotovsky B; Gogvadze V
Article: ACS BIOMATERIALS SCIENCE & ENGINEERING. 2019;5(11):6063-6071
Biodegradable Porous Silicon Nanocontainers as an Effective Drug Carrier for Regulation of the Tumor Cell Death Pathways
Maximchik PV; Tamarov K; Sheval EV; Tolstik E; Kirchberger-Tolstik T; Yang Z; Sivakov V; Zhivotovsky B; Osminkina LA
Article: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE. 2019;168(1):132-140
Isolation of High-Molecular-Weight Activation Complexes of Initiator Caspases in DNA Damage
Zamaraev AV; Egorshina AY; Lavrik IN; Zhivotovsky BD; Kopeina GS
Article: BIOLOGICAL CHEMISTRY. 2019;400(2):161-170
Involvement of mitophagy in cisplatin-induced cell death regulation
Abdrakhmanov A; Kulikov AV; Luchkina EA; Zhivotovsky B; Gogvadze V
Article: FEBS JOURNAL. 2018;285(24):4590-4601
2-Deoxy-D-glucose has distinct and cell line-specific effects on the survival of different cancer cells upon antitumor drug treatment
Maximchik P; Abdrakhmanov A; Inozemtseva E; Tyurin-Kuzmin PA; Zhivotovsky B; Gogvadze V
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2018;102:101-108
Caspase-2 is a negative regulator of necroptosis
Zamaraev AV; Kopeina GS; Buchbinder JH; Zhivotovsky B; Lavrik IN
Article: SCIENTIFIC REPORTS. 2018;8(1):12199
Apoptosis regulation by subcellular relocation of caspases
Prokhorova EA; Kopeina GS; Lavrik IN; Zhivotovsky B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2018;499(4):822-828
Caspase-2 associates with FAN through direct interaction and overlapping functionality
Forsberg J; Li X; Zamaraev AV; Panaretakis T; Zhivotovsky B; Olsson M
Article: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 2018;1862(3):557-566
Modulation of Mcl-1 transcription by serum deprivation sensitizes cancer cells to cisplatin
Senichkin VV; Kopeina GS; Prokhorova EA; Zamaraev AV; Lavrik IN; Zhivotovsky B
Article: AUTOPHAGY. 2018;14(2):252-268
Suppressed translation as a mechanism of initiation of CASP8 (caspase 8)-dependent apoptosis in autophagy-deficient NSCLC cells under nutrient limitation
Allavena G; Cuomo F; Baumgartner G; Bele T; Sellgren AY; Oo KS; Johnson K; Gogvadze V; Zhivotovsky B; Kaminskyy VO
Article: CELL DEATH & DISEASE. 2018;9(2):80
A caspase-2-RFXANK interaction and its implication for MHC class II expression
Forsberg J; Li X; Akpinar B; Salvatori R; Ott M; Zhivotovsky B; Olsson M
Article: SCIENTIFIC REPORTS. 2017;7(1):14571
Involvement of autophagy in the outcome of mitotic catastrophe
Sorokina IV; Denisenko TV; Imreh G; Tyurin-Kuzmin PA; Kaminskyy VO; Gogvadze V; Zhivotovsky B
Article: RSC MEDICINAL CHEMISTRY. 2017;8(10):1934-1945
Mitochondria-targeted betulinic and ursolic acid derivatives: synthesis and anticancer activity
Nedopekina DA; Gubaidullin RR; Odinokov VN; Maximchik PV; Zhivotovsky B; Bel'skii YP; Khazanov VA; Manuylova AV; Gogvadze V; Spivak AY
Article: JOURNAL OF INTERNAL MEDICINE. 2017;281(5):483-495
Understanding cell cycle and cell death regulation provides novel weapons against human diseases
Wiman KG; Zhivotovsky B
Article: BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH. 2017;1864(3):498-506
Contrasting effects of glutamine deprivation on apoptosis induced by conventionally used anticancer drugs
Valter K; Chen L; Kruspig B; Maximchik P; Cui H; Zhivotovsky B; Gogvadze V
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2017;482(3):432-439
Mitophagy: Link to cancer development and therapy
Kulikov AV; Luchkina EA; Gogvadze V; Zhivotovsky B
Article: DOKLADY BIOCHEMISTRY AND BIOPHYSICS. 2017;472(1):27-30
Inhibition of P-glycoprotein stimulates cell death under Hypoxia-mimicking conditions
Vdovin AS; Maximchik PV; Kulikov AV; Zhivotovsky BD; Gogvadze VG
Article: BLOOD. 2016;128(23):2655-2665
Caspase-3-dependent cleavage of Bcl-xL in the stroma exosomes is required for their uptake by hematological malignant cells
Vardaki I; Sanchez C; Fonseca P; Olsson M; Chioureas D; Rassidakis G; Ullen A; Zhivotovsky B; Bjorkholm M; Panaretakis T
Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2016;81(Pt A):133-136
Reactive oxygen species regulate a balance between mitotic catastrophe and apoptosis
Sorokina IV; Denisenko TV; Imreh G; Gogvadze V; Zhivotovsky B
Article: AUTOPHAGY. 2016;12(11):2085-2097
Suppressed translation and ULK1 degradation as potential mechanisms of autophagy limitation under prolonged starvation
Allavena G; Boyd C; Oo KS; Maellaro E; Zhivotovsky B; Kaminskyy VO
Article: ONCOTARGET. 2016;7(37):60332-60347
Ephrin B3 interacts with multiple EphA receptors and drives migration and invasion in non-small cell lung cancer
Efazat G; Novak M; Kaminskyy VO; De Petris L; Kanter L; Juntti T; Bergman P; Zhivotovsky B; Lewensohn R; Haag P; Viktorsson K
Article: ONCOTARGET. 2016;7(36):58286-58301
Aberrant DR5 transport through disruption of lysosomal function suggests a novel mechanism for receptor activation
Akpinar B; Safarikova B; Laukova J; Debnath S; Vaculova AH; Zhivotovsky B; Olsson M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2016;1863(8):2065-2071
Targeting succinate:ubiquinone reductase potentiates the efficacy of anticancer therapy
Kruspig B; Valter K; Skender B; Zhivotovsky B; Gogvadze V
Article: DOKLADY BIOCHEMISTRY AND BIOPHYSICS. 2016;467(1):132-135
Mechanism of caspase-2 activation upon DNA damage
Aksenova VI; Kopeina GS; Zamaraev AV; Zhivotovsky BD; Lavrik IN
Article: RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY. 2016;42(1):74-82
Identification of new complex for caspase-2 activation after DNA damage
Kopeina GS; Zamaraev AV; Zhivotovsky BD; Lavrika IN
Article: ONCOTARGET. 2015;6(41):43679-43697
5-Fluorouracil-induced RNA stress engages a TRAIL-DISC-dependent apoptosis axis facilitated by p53
Akpinar B; Bracht EV; Reijnders D; Safarikova B; Jelinkova I; Grandien A; Vaculova AH; Zhivotovsky B; Olsson M
Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2015;30(12):2249-2261
Targeted Deletion of Autophagy Genes Atg5 or Atg7 in the Chondrocytes Promotes Caspase-Dependent Cell Death and Leads to Mild Growth Retardation
Vuppalapati KK; Bouderlique T; Newton PT; Kaminskyy VO; Wehtje H; Ohlsson C; Zhivotovsky B; Chagin AS
Article: ONCOTARGET. 2015;6(35):37066-37082
Sorafenib-induced defective autophagy promotes cell death by necroptosis
Kharaziha P; Chioureas D; Baltatzis G; Fonseca P; Rodriguez P; Gogvadze V; Lennartsson L; Bjorklund A-C; Zhivotovsky B; Grander D; Egevad L; Nilsson S; Panaretakis T
Article: ONCOTARGET. 2015;6(14):12156-12173
Tudor staphylococcal nuclease drives chemoresistance of non-small cell lung carcinoma cells by regulating S100A11
Zagryazhskaya A; Surova O; Akbar NS; Allavena G; Gyuraszova K; Zborovskaya IB; Tchevkina EM; Zhivotovsky B
Article: ACTA NATURAE. 2015;7(1):6-8
Milestones of World Life Science Mitochondriology and Cell Energy Supply
Zhivotovsky BD; Gogvadze VG; Tkachuk VA
Article: METHODS IN MOLECULAR BIOLOGY. 2015;1264:385-393
Analysis of mitochondrial dysfunction during cell death.
Gogvadze V; Orrenius S; Zhivotovsky B
Article: INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY. 2015;59(1-3):119-129
Cell death in cancer therapy of lung adenocarcinoma
Zagryazhskaya A; Gyuraszova K; Zhivotovsky B
Article: GENES & DEVELOPMENT. 2014;28(24):2726-2738
The scaffold protein WRAP53β orchestrates the ubiquitin response critical for DNA double-strand break repair
Henriksson S; Rassoolzadeh H; Hedstrom E; Coucoravas C; Julner A; Goldstein M; Imreh G; Zhivotovsky B; Kastan MB; Helleday T; Farnebo M
Article: MITOCHONDRION. 2014;19:105-112
Mesenchymal stem cells and hypoxia: Where are we?
Buravkova LB; Andreeva ER; Gogvadze V; Zhivotovsky B
Article: MITOCHONDRION. 2014;19:8-19
Mitochondrial substrates in cancer: Drivers or passengers?
Kruspig B; Zhivotovsky B; Gogvadze V
Article: ONCOGENE. 2014;33(27):3538-3549
Inhibition of the mitochondrial pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase by doxorubicin and brequinar sensitizes cancer cells to TRAIL-induced apoptosis
He T; Haapa-Paananen S; Kaminskyy VO; Kohonen P; Fey V; Zhivotovsky B; Kallioniemi O; Perala M
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2014;71(12):2325-2333
Targeting mitochondria by α-tocopheryl succinate overcomes hypoxia-mediated tumor cell resistance to treatment
Kulikov AV; Vdovin AS; Zhivotovsky B; Gogvadze V
Article: METHODS IN MOLECULAR BIOLOGY. 2014;1133:155-173
Measurement of caspase activation in mammalian cell cultures.
Olsson M; Zhivotovsky B
Article: JOURNAL OF CELL BIOLOGY. 2013;203(6):917-927
Autophagy and metacaspase determine the mode of cell death in plants
Minina EA; Filonova LH; Fukada K; Savenkov EI; Gogvadze V; Clapham D; Sanchez-Vera V; Suarez MF; Zhivotovsky B; Daniel G; Smertenko A; Bozhkov PV
Article: ONCOGENE. 2013;32(49):5531-5540
S100A4 interacts with p53 in the nucleus and promotes p53 degradation
Orre LM; Panizza E; Kaminskyy VO; Vernet E; Graslund T; Zhivotovsky B; Lehtio J
Article: CELL DEATH & DISEASE. 2013;4(12):e940
Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death
Vakifahmetoglu-Norberg H; Norberg E; Perdomo AB; Olsson M; Ciccosanti F; Orrenius S; Fimia GM; Piacentini M; Zhivotovsky B
Article: INTERNATIONAL JOURNAL OF CANCER. 2013;133(7):1643-1652
Doxorubicin sensitizes human tumor cells to NK cell- and T-cell-mediated killing by augmented TRAIL receptor signaling.
Wennerberg E; Sarhan D; Carlsten M; Kaminskyy VO; D'Arcy P; Zhivotovsky B; Childs R; Lundqvist A
Article: GENES CHROMOSOMES & CANCER. 2013;52(10):895-911
miRNA-214 is related to invasiveness of human non-small cell lung cancer and directly regulates alpha protein kinase 2 expression
Salim H; Arvanitis A; de Petris L; Kanter L; Haag P; Zovko A; Ozata DM; Lui W-O; Lundholm L; Zhivotovsky B; Lewensohn R; Viktorsson K
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1833(10):2279-2292
Determining the contributions of caspase-2, caspase-8 and effector caspases to intracellular VDVADase activities during apoptosis initiation and execution
Delgado ME; Olsson M; Lincoln FA; Zhivotovsky B; Rehm M
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1830(10):4418-4425
Low ATP level is sufficient to maintain the uncommitted state of multipotent mesenchymal stem cells
Buravkova LB; Rylova YV; Andreeva ER; Kulikov AV; Pogodina MV; Zhivotovsky B; Gogvadze V
Article: ONCOGENE. 2013;32(38):4529-4538
5-Fluorouracil signaling through a calcium-calmodulin-dependent pathway is required for p53 activation and apoptosis in colon carcinoma cells
Can G; Akpinar B; Baran Y; Zhivotovsky B; Olsson M
Article: MITOCHONDRION. 2013;13(5):533-538
Contrasting effects of α-tocopheryl succinate on cisplatin- and etoposide-induced apoptosis
Kruspig B; Zhivotovsky B; Gogvadze V
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2013;57:176-187
Reactive oxygen species generated in different compartments induce cell death, survival, or senescence
Panieri E; Gogvadze V; Norberg E; Venkatesh R; Orrenius S; Zhivotovsky B
Article: CELL DEATH & DISEASE. 2013;4(3):e522
Upregulation of c-FLIP-short in response to TRAIL promotes survival of NSCLC cells, which could be suppressed by inhibition of Ca²⁺/calmodulin signaling
Kaminskyy VO; Surova OV; Piskunova T; Zborovskaya IB; Tchevkina EM; Andera L; Zhivotovsky B
Article: ANTIOXIDANTS & REDOX SIGNALING. 2013;18(5):491-506
Targeting Hepatoma Using Nitric Oxide Donor Strategies
Gonzalez R; Ferrin G; Aguilar-Melero P; Ranchal I; Linares CI; Bello RI; De la Mata M; Gogvadze V; Barcena JA; Alamo JM; Orrenius S; Padillo FJ; Zhivotovsky B; Muntane J
Article: CELL DEATH & DISEASE. 2013;4(1):e454
Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412
Stahl S; Kaminskyy VO; Efazat G; Vaculova AH; Rodriguez-Nieto S; Moshfegh A; Lewensohn R; Viktorsson K; Zhivotovsky B
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2012;69(24):4229-4237
Citrate kills tumor cells through activation of apical caspases
Kruspig B; Nilchian A; Orrenius S; Zhivotovsky B; Gogvadze V
Article: BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE. 2012;154(1):141-144
Etoposide and Hypoxia Do Not Activate Apoptosis of Multipotent Mesenchymal Stromal Cells In Vitro
Rylova JV; Andreeva ER; Gogvadze VG; Zhivotovsky BD; Buravkova LB
Article: CANCER RESEARCH. 2012;72(20):5348-5362
Sorafenib Has Potent Antitumor Activity against Multiple Myeloma In Vitro, Ex Vivo, and In Vivo in the 5T33MM Mouse Model
Kharaziha P; De Raeve H; Fristedt C; Li Q; Gruber A; Johnsson P; Kokaraki G; Panzar M; Laane E; Osterborg A; Zhivotovsky B; Jernberg-Wiklund H; Grander D; Celsing F; Bjorkholm M; Vanderkerken K; Panaretakis T
Article: BRITISH JOURNAL OF CANCER. 2012;107(8):1361-1373
miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence
Salim H; Akbar NS; Zong D; Vaculova AH; Lewensohn R; Moshfegh A; Viktorsson K; Zhivotovsky B
Article: AUTOPHAGY. 2012;8(7):1032-1044
Suppression of basal autophagy reduces lung cancer cell proliferation and enhances caspase-dependent and -independent apoptosis by stimulating ROS formation
Kaminskyy VO; Piskunova T; Zborovskaya IB; Tchevkina EM; Zhivotovsky B
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2012;69(12):2091-2099
Targeting mitochondria by α-tocopheryl succinate kills neuroblastoma cells irrespective of MycN oncogene expression
Kruspig B; Nilchian A; Bejarano I; Orrenius S; Zhivotovsky B; Gogvadze V
Article: PLOS ONE. 2012;7(3):e33134
Knock-Down of Core Proteins Regulating MicroRNA Biogenesis Has No Effect on Sensitivity of Lung Cancer Cells to Ionizing Radiation
Surova O; Akbar NS; Zhivotovsky B
Article: RSC ADVANCES. 2012;2(10):4228-4235
Structural characterization, solution stability, and potential health and environmental effects of the Nano-TiO₂ bioencapsulation matrix and the model product of its biodegradation TiBALDH
Groenke N; Seisenbaeva GA; Kaminskyy V; Zhivotovsky B; Kost B; Kessler VG
Article: CARCINOGENESIS. 2011;32(10):1450-1458
Combined inhibition of DNA methyltransferase and histone deacetylase restores caspase-8 expression and sensitizes SCLC cells to TRAIL
Kaminskyy VO; Surova OV; Vaculova A; Zhivotovsky B
Article: JOURNAL OF CELL SCIENCE. 2011;124(17):2951-2963
Chromosomal breaks during mitotic catastrophe trigger γH2AX-ATM-p53-mediated apoptosis (Publication with Expression of Concern. See vol. 130, pg. 3418, 2017) (Publication with Expression of Concern. See vol. 130, pg. 1979, 2017)
Imreh G; Norberg HV; Imreh S; Zhivotovsky B
Article: JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 2011;15(8):1757-1768
Hsp72 mediates TAp73α anti-apoptotic effects in small cell lung carcinoma cells
Nyman U; Muppani NR; Zhivotovsky B; Joseph B
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2011;50(11):1546-1555
Mitochondrial targeting of α-tocopheryl succinate enhances its pro-apoptotic efficacy: A new paradigm for effective cancer therapy
Dong L-F; Jameson VJA; Tilly D; Prochazka L; Rohlena J; Valis K; Truksa J; Zobalova R; Mandavian E; Kluckova K; Stantic M; Stursa J; Freeman R; Witting PK; Norberg E; Goodwin J; Salvatore BA; Novotna J; Turanek J; Ledvina M; Hozak P; Zhivotovsky B; Coster MJ; Ralph SJ; Smith RAJ; Neuzil J
Article: JOURNAL OF PROTEOME RESEARCH. 2011;10(5):2566-2578
Phosphoproteomic Profiling of NSCLC Cells Reveals that Ephrin B3 Regulates Pro-survival Signaling through Akt1-Mediated Phosphorylation of the EphA2 Receptor
Stahl S; Branca RM; Efazat G; Ruzzene M; Zhivotovsky B; Lewensohn R; Viktorsson K; Lehtio J
Article: BIOCHIMIE. 2011;93(2):306-313
Transcription factor GABP/NRF-2 controlling biogenesis of mitochondria regulates basal expression of peroxiredoxin V but the mitochondrial function of peroxiredoxin V is dispensable in the dog
Usmanova N; Tomilin N; Zhivotovsky B; Kropotov A
Article: TOXICOLOGICAL SCIENCES. 2011;119(1):3-19
Cell Death Mechanisms and Their Implications in Toxicology
Orrenius S; Nicotera P; Zhivotovsky B
Article: AUTOPHAGY. 2011;7(1):83-90
A quantitative assay for the monitoring of autophagosome accumulation in different phases of the cell cycle
Kaminskyy V; Abdi A; Zhivotovsky B
Article: SCIENCE SIGNALING. 2010;3(152):pe48
Aspasing Out Metacaspases and Caspases: Proteases of Many Trades
Bozhkov PV; Smertenko AP; Zhivotovsky B
Article: EMBO JOURNAL. 2010;29(22):3869-3878
Critical role for hyperpolarization-activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis
Norberg E; Karlsson M; Korenovska O; Szydlowski S; Silberberg G; Uhlen P; Orrenius S; Zhivotovsky B
Article: JOURNAL OF INTERNAL MEDICINE. 2010;268(5):395-409
Cell cycle and cell death in disease: past, present and future
Zhivotovsky B; Orrenius S
Article: INTERNATIONAL JOURNAL OF CANCER. 2010;127(8):1823-1832
Involvement of Ca²⁺ and ROS in α-tocopheryl succinate-induced mitochondrial permeabilization
Gogvadze V; Norberg E; Orrenius S; Zhivotovsky B
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2010;149(6):844-854
Gene expression profiling of erythroblasts from refractory anaemia with ring sideroblasts (RARS) and effects of G-CSF
Nikpour M; Pellagatti A; Liu A; Karimi M; Malcovati L; Gogvadze V; Forsblom A-M; Wainscoat JS; Cazzola M; Zhivotovsky B; Grandien A; Boultwood J; Hellstrom-Lindberg E
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2010;396(1):95-100
Mitochondrial regulation of cell death: Processing of apoptosis-inducing factor (AIF)
Norberg E; Orrenius S; Zhivotovsky B
Article: JOURNAL OF INTERNAL MEDICINE. 2010;267(5):473-482
To kill or be killed: how viruses interact with the cell death machinery
Kaminskyy V; Zhivotovsky B
Article: MOLECULAR CANCER. 2010;9:87
Doxorubicin and etoposide sensitize small cell lung carcinoma cells expressing caspase-8 to TRAIL
Vaculova A; Kaminskyy V; Jalalvand E; Surova O; Zhivotovsky B
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2010;48(6):791-797
Oxidative modification sensitizes mitochondrial apoptosis-inducing factor to calpain-mediated processing
Norberg E; Gogvadze V; Vakifahmetoglu H; Orrenius S; Zhivotovsky B
Article: PLOS COMPUTATIONAL BIOLOGY. 2010;6(3):e1000702
Mathematical Modelling of Cell-Fate Decision in Response to Death Receptor Engagement
Calzone L; Tournier L; Fourquet S; Thieffry D; Zhivotovsky B; Barillot E; Zinovyev A
Article: PEDIATRIC RESEARCH. 2009;66(6):654-659
Epiphyseal Fusion in the Human Growth Plate Does not Involve Classical Apoptosis
Emons J; Chagin AS; Hultenby K; Zhivotovsky B; Wit JM; Karperien M; Savendahl L
Article: NATURE CELL BIOLOGY. 2009;11(11):1347-U198
Tudor staphylococcal nuclease is an evolutionarily conserved component of the programmed cell death degradome
Sundstrom JF; Vaculova A; Smertenko AP; Savenkov EI; Golovko A; Minina E; Tiwari BS; Rodriguez-Nieto S; Zamyatnin AAJ; Valineva T; Saarikettu J; Frilander MJ; Suarez MF; Zavialov A; Stahl U; Hussey PJ; Silvennoinen O; Sundberg E; Zhivotovsky B; Bozhkov PV
Article: CELL DEATH AND DIFFERENTIATION. 2009;16(7):1018-1029
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
Laane E; Tamm KP; Buentke E; Ito K; Kharaziha P; Oscarsson J; Corcoran M; Bjorklund A-C; Hultenby K; Lundin J; Heyman M; Soderhall S; Mazur J; Porwit A; Pandolfi PP; Zhivotovsky B; Panaretakis T; Grander D
Article: CANCER LETTERS. 2009;278(2):183-191
Coding polymorphisms in Casp5, Casp8 and DR4 genes may play a role in predisposition to lung cancer
Ulybina YM; Kuligina ES; Mitiushkina NV; Rozanov ME; Ivantsov AO; Ponomariova DN; Togo AV; Levchenko EV; Shutkin VA; Brenister SI; Devilee P; Zhivotovsky B; Hirvonen A; Imyanitov EN
Article: ONCOGENE. 2009;28(18):1949-1959
DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis
Olsson M; Vakifahmetoglu H; Abruzzo PM; Hogstrand K; Grandien A; Zhivotovsky B
Article: MOLECULAR AND CELLULAR BIOLOGY. 2009;29(7):1814-1825
Protein Kinase C-Dependent Phosphorylation Regulates the Cell Cycle-Inhibitory Function of the p73 Carboxy Terminus Transactivation Domain
Nyman U; Vlachos P; Cascante A; Hermanson O; Zhivotovsky B; Joseph B
Article: CELL DEATH AND DIFFERENTIATION. 2008;15(12):1857-1864
An increase in intracellular Ca²⁺ is required for the activation of mitochondrial calpain to release AIF during cell death
Norberg E; Gogvadze V; Ott M; Uhlen P; Orrenius S; Zhivotovsky B
Article: ONCOGENE. 2008;27(31):4363-4372
p73 and caspase-cleaved p73 fragments localize to mitochondria and augment TRAIL-induced apoptosis
Sayan AE; Sayan BS; Gogvadze V; Dinsdale D; Nyman U; Hansen TM; Zhivotovsky B; Cohen GM; Knight RA; Melino G
Article: APOPTOSIS. 2008;13(3):354-363
Caspase-2 activation in neural stem cells undergoing oxidative stress-induced apoptosis
Tamm C; Zhivotovsky B; Ceccatelli S
Article: CELL DEATH AND DIFFERENTIATION. 2008;15(3):555-566
DNA damage induces two distinct modes of cell death in ovarian carcinomas
Vakifahmetoglu H; Olsson M; Tamm C; Heidari N; Orrenius S; Zhivotovsky B
Article: EXPERIMENTAL HEMATOLOGY. 2008;36(2):149-157
Hypomethylation and apoptosis in 5-azacytidine-treated myeloid cells
Khan R; Schmidt-Mende J; Karim M; Gogvadze V; Hassan M; Ekstrom TJ; Zhivotovsky B; Hellstrom-Lindberg E
Article: FEBS JOURNAL. 2007;274(22):5804-5814
Mitochondrial targeting of human peroxiredoxin V protein and regulation of PRDX5 gene expression by nuclear transcription factors controlling biogenesis of mitochondria
Kropotov A; Usmanova N; Serikov V; Zhivotovsky B; Tomilin N
Article: HAEMATOLOGICA. 2007;92(11):1460-1469
Dexamethasone-induced apoptosis in acute lymphoblastic leukemia involves differential regulation of Bcl-2 family members
Laane E; Panaretakis T; Pokrovskaja K; Buentke E; Corcoran M; Soderhall S; Heyman M; Mazur J; Zhivotovsky B; Porwit A; Grander D
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2007;66(4):410-421
Participation of FLIP, RIP and Bcl-x_L in fas-mediated T-cell death
Djerbi M; Malinowski MM; Yagita H; Zhivotovsky B; Grandien A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2007;282(38):27633-27639
The mitochondrial TOM complex is required for tBid/Bax-induced cytochrome c release
Ott M; Norberg E; Walter KM; Schreiner P; Kemper C; Rapaport D; Zhivotovsky B; Orrenius S
Article: APOPTOSIS. 2007;12(5):913-922
Mitochondria, oxidative stress and cell death
Ott M; Gogvadze V; Orrenius S; Zhivotovsky B
Article: ONCOGENE. 2006;25(41):5683-5692
Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage
Vakifahmetoglu H; Olsson M; Orrenius S; Zhivotovsky B
Article: EXPERIMENTAL CELL RESEARCH. 2006;312(15):2806-2815
Peroxiredoxin V is essential for protection against apoptosis in human lung carcinoma cells
Kropotov A; Gogvadze V; Shupliakov O; Tomilin N; Serikov VB; Tomilin NV; Zhivotovsky B
Article: INTERNATIONAL JOURNAL OF CANCER. 2006;119(5):1028-1038
Inhibitors of the PI3-kinase/Akt pathway induce mitotic catastrophe in non-small cell lung cancer cells
Hemstrom TH; Sandstrom M; Zhivotovsky B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2006;19(6):729-733
The future of toxicologys - Does it matter how cells die?
Orrenius S; Zhivotovsky B
Article: FEBS JOURNAL. 2006;273(12):2607-2617
Constitutive expression of the human peroxiredoxin V gene contributes to protection of the genome from oxidative DNA lesions and to suppression of transcription of noncoding DNA
Kropotov A; Serikov V; Suh J; Smirnova A; Bashkirov V; Zhivotovsky B; Tomilin N
Article: MICROBES AND INFECTION. 2006;8(6):1560-1568
Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis
Nyakeriga AM; Perlmann H; Hagstedt M; Berzins K; Troye-Blomberg M; Zhivotovsky B; Perlmann P; Grandien A
Article: CANCER RESEARCH. 2006;66(8):4410-4418
Inhibition of mammalian thioredoxin reductase by some flavonoids: Implications for myricetin and quercetin anticancer activity
Lu J; Papp LV; Fang JG; Rodriguez-Nieto S; Zhivotovsky B; Holmgren A
Article: CELL DEATH AND DIFFERENTIATION. 2006;13(1):119-128
Early mitochondrial alterations in ATRA-induced cell death
Schmidt-Mende J; Gogvadze V; Hellström-Lindberg E; Zhivotovsky B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(40):34159-34169
Full-length p73α represses drug-induced apoptosis in small cell lung carcinoma cells
Nyman U; Sobczak-Pluta A; Vlachos P; Perlmann T; Zhivotovsky B; Joseph B
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2005;102(40):14463-14468
Cysteine protease mcll-Pa executes programmed cell death during plant embryogenesis
Bozhkov PV; Suarez MF; Filonova LH; Daniel G; Zamyatnin AAJ; Rodriguez-Nieto S; Zhivotovsky B; Smertenko A
Article: CLINICAL CANCER RESEARCH. 2005;11(17):6291-6299
Antiapoptotic role of growth factors in the Myelodysplastic syndromes: Concordance between in vitro and in vivo observations
Tehranchi R; Fadeel B; Schmidt-Mende J; Forsblom AM; Emanuelsson E; Jadersten M; Christensson B; Hast R; Howe RB; Samuelsson J; Zhivotovsky B; Hollström-Lindberg E
Article: MOLECULAR BIOLOGY OF THE CELL. 2005;16(8):3821-3831
Doxorubicin requires the sequential activation of caspase-2, protein kinase Cδ, and c-Jun NH₂-terminal kinase to induce apoptosis
Panaretakis T; Laane E; Pokrovskaja K; Björklund AC; Moustakas A; Zhivotovsky B; Heyman M; Shoshan MC; Grandér D
Article: BLOOD. 2005;106(1):247-253
Aberrant mitochondrial iron distribution and maturation arrest characterize early erythroid precursors in low-risk myelodysplastic syndromes
Tehranchi R; Invernizzi R; Grandien A; Zhivotovsky B; Fadeel B; Forsblom AM; Travaglino E; Samuelsson J; Hast R; Nilsson L; Cazzola M; Wibom R; Hellström-Lindberg E
Article: EXPERIMENTAL CELL RESEARCH. 2005;305(1):200-213
PKC 412 sensitizes U1810 non-small cell lung cancer cells to DNA damage
Hemström TH; Joseph B; Schulte G; Lewensohn R; Zhivotovsky B
Article: JOURNAL OF INTERFERON AND CYTOKINE RESEARCH. 2005;25(2):63-72
The HPV-16 E7 oncogene sensitizes malignant cells to IFN-α-induced apoptosis
Thyrell L; Sangfelt O; Zhivotovsky B; Pokrovskaja K; Wang YS; Einhorn S; Grandér D
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(48):49575-49578
Caspase-2 permeabilizes the outer mitochondrial membrane and disrupts the binding of cytochrome c to anionic phospholipids
Enoksson M; Robertson JD; Gogvadze V; Bu PL; Kropotov A; Zhivotovsky B; Orrenius S
Article: ONCOGENE. 2004;23(37):6282-6291
Apoptosis-inducing factor determines the chemoresistance of non-small-cell lung carcinomas
Gallego MA; Joseph B; Hemström TH; Tamiji S; Mortier L; Kroemer G; Formstecher P; Zhivotovsky B; Marchetti P
Article: FEBS LETTERS. 2004;572(1-3):75-79
Downregulation of Peroxiredoxin V stimulates formation of etoposide-induced double-strand DNA breaks
Kropotov AV; Grudinkin PS; Pleskach NM; Gavrilov BA; Tomilin NV; Zhivotovsky B
Article: EXPERIMENTAL CELL RESEARCH. 2004;298(1):83-95
Endogenously released Smac is insufficient to mediate cell death of human lung carcinoma in response to etoposide
Bartling B; Lewensohn R; Zhivotovsky B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(23):24152-24162
Interferon α-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway
Thyrell L; Hjortsberg L; Arulampalam V; Panaretakis T; Uhles S; Dagnell M; Zhivotovsky B; Leibiger I; Grandér D; Pokrovskaja K
Article: CARCINOGENESIS. 2004;25(6):909-921
RasGTPase-activating protein is a target of caspases in spontaneous apoptosis of lung carcinoma cells and in response to etoposide
Bartling B; Yang JY; Michod D; Widmann C; Lewensohn R; Zhivotovsky B
Article: EMBO REPORTS. 2004;5(6):643-648
Processed caspase-2 can induce mitochondria-mediated apoptosis independently of its enzymatic activity
Robertson JD; Gogvadze V; Kropotov A; Vakifahmetoglu H; Zhivotovsky B; Orrenius S
Article: CANCER RESEARCH. 2004;64(10):3679-3686
Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for K1-5-Induced antiangiogenesis
Veitonmäki N; Cao R; Wu LH; Moser TL; Li B; Pizzo SV; Boris ZY; Cao YH
Article: CURRENT PROTOCOLS IN TOXICOLOGY / EDITORIAL BOARD, MAHIN D. MAINES (EDITOR-IN-CHIEF) ... [ET AL.]. 2004;Chapter 2:Unit2.10-2.10.27
Analysis of mitochondrial dysfunction during cell death.
Gogvadze V; Orrenius S; Zhivotovsky B
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2004;36(7):881-896
The transcriptosomal response of human A549 lung cells to a hydrogen peroxide-generating system:: Relationship to DNA damage, cell cycle arrest, and caspase activation
Dandrea T; Hellmold H; Jonsson C; Zhivotovsky B; Hofer T; Wärngård L; Cotgreave I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2004;101(8):2476-2481
Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis
Bråkenhielm E; Veitonmäki N; Cao RH; Kihara S; Matsuzawa YJ; Zhivotovsky B; Funahashi T; Cao YH
Article: BIOCHEMICAL JOURNAL. 2004;378(Pt 1):213-217
Mitochondrial cytochrome c release may occur by volume-dependent mechanisms not involving permeability transition
Gogvadze V; Robertson JD; Enoksson M; Zhivotovsky B; Orrenius S
Article: CELL DEATH AND DIFFERENTIATION. 2004;11(2):175-182
VEIDase is a principal caspase-like activity involved in plant programmed cell death and essential for embryonic pattern formation
Bozhkov PV; Filonova LH; Suarez MF; Helmersson A; Smertenko AP; Zhivotovsky B; von Arnold S
Article: CELL CYCLE. 2004;3(1):64-66
Apoptosis, necrosis and between
Zhivotovsky B
Article: CANCER BIOLOGY & THERAPY. 2003;2(6):663-669
Heat shock protein 72 does not modulate ionizing radiation-induced apoptosis in U1810 non-small cell lung carcinoma cells
Ekedahl J; Joseph B; Marchetti P; Fauvel H; Formstecher P; Lewensohn R; Zhivotovsky B
Article: EXPERIMENTAL CELL RESEARCH. 2003;289(2):256-264
Defective stress kinase and Bak activation in response to ionizing radiation but not cisplatin in a non-small cell lung carcinoma cell line
Viktorsson K; Ekedahl J; Lindebro MC; Lewensohn R; Zhivotovsky B; Linder S; Shoshan MC
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2003;307(4):942-947
Effects of 9-β-D-arabinofuranosylguanine on mitochondria in CEM T-lymphoblast leukemia cells
Curbo S; Zhivotovsky B; Johansson M; Karlsson A
Article: CURRENT PROTOCOLS IN CELL BIOLOGY. 2003;Chapter 18:Unit-18.5
Analysis of mitochondrial dysfunction during cell death.
Gogvadze V; Orrenius S; Zhivotovsky B
Article: SEMINARS IN CANCER BIOLOGY. 2003;13(2):125-134
Defects in the apoptotic machinery of cancer cells: role in drug resistance
Zhivotovsky B; Orrenius S
Article: BLOOD. 2003;101(3):1080-1086
Granulocyte colony-stimulating factor inhibits spontaneous cytochrome c release and mitochondria-dependent apoptosis of myelodysplastic syndrome hematopoietic progenitors
Tehranchi R; Fadeel B; Forsblom AM; Christensson B; Samuelsson J; Zhivotovsky B; Hellstrom-Lindberg E
Article: EXPERIMENTAL CELL RESEARCH. 2002;279(2):277-290
Expression of inhibitor of apoptosis proteins in small- and non-small-cell lung carcinoma cells
Ekedahl J; Joseph B; Grigoriev MY; Müller M; Magnusson C; Lewensohn R; Zhivotovsky B
Article: CELL CYCLE. 2002;1(5):337-342
Expression of Caspase-3 and-7 Does Not Correlate with the Extent of Apoptosis in Primary Breast Carcinomas
Grigoriev MY; Pozharissky KM; Hanson KP; Imyanitov EN; Zhivotovsky B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2002;277(33):29803-29809
Caspase-2 acts upstream of mitochondria to promote cytochrome c release during etoposide-induced apoptosis
Robertson JD; Enoksson M; Suomela M; Zhivotovsky B; Orrenius S
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2002;265(1-2):97-110
Evaluation of caspase activity in apoptotic cells
Köhler C; Orrenius S; Zhivotovsky B
Article: CELL DEATH AND DIFFERENTIATION. 2002;9(3):301-308
A matrix-assisted laser desorption ionization post-source decay (MALDI-PSD) analysis of proteins released from isolated liver mitochondria treated with recombinant truncated Bid
Van Loo G; Demol H; van Gurp M; Hoorelbeke B; Schotte P; Beyaert R; Zhivotovsky B; Gevaert K; Declercq W; Vandekerckhove J; Vandenabeele P
Article: ONCOGENE. 2002;21(8):1251-1262
Mechanisms of Interferon-alpha induced apoptosis in malignant cells
Thyrell L; Erickson S; Zhivotovsky B; Pokrovskaja K; Sangfelt O; Castro J; Einhorn S; Grandér D
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2002;99(3):1259-1263
Cytochrome c release from mitochondria proceeds by a two-step process
Ott M; Robertson JD; Gogvadze V; Zhivotovsky B; Orrenius S
Article: ONCOGENE. 2002;21(1):65-77
Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment
Joseph B; Marchetti P; Formstecher P; Kroemer G; Lewensohn R; Zhivotovsky B
Article: CURRENT PROTOCOLS IN CELL BIOLOGY. 2001;Chapter 18:Unit-18.1
Current concepts in cell death.
Zhivotovsky B; Orrenius S
Article: CELL DEATH AND DIFFERENTIATION. 2001;8(8):829-840
Death receptor-induced apoptotic and necrotic cell death: differential role of caspases and mitochondria
Denecker G; Vercammen D; Steemans M; Vanden Berghe T; Brouckaert G; Van Loo G; Zhivotovsky B; Fiers W; Grooten J; Declercq W; Vandenabeele P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2001;54(1-2):180-189
Characterization of the human FLICE-inhibitory protein locus and comparison of the anti-apoptotic activity of four different FLIP isoforms
Djerbi M; Darreh-Shori T; Zhivotovsky B; Grandien A
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2001;30(12):1347-1356
Methylmercury and H₂O₂ provoke lysosomal damage in human astrocytoma D384 cells followed by apoptosis
Daré E; Li W; Zhivotovsky B; Yuan XM; Ceccatelli S
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(22):19066-19071
Cytochrome c release occurs via Ca²⁺-dependent and Ca²⁺-independent mechanisms that are regulated by Bax
Gogvadze V; Robertson JD; Zhivotovsky B; Orrenius S
Article: ONCOGENE. 2001;20(23):2877-2888
Defective caspase-3 relocalization in non-small cell lung carcinoma
Joseph B; Ekedahl J; Lewensohn R; Marchetti P; Formstecher P; Zhivotovsky B
Article: CURRENT PROTOCOLS IN TOXICOLOGY / EDITORIAL BOARD, MAHIN D. MAINES (EDITOR-IN-CHIEF) ... [ET AL.]. 2001;Chapter 2:Unit-2.2
Determination of apoptosis and necrosis.
Zhivotovsky B; Samali A; Orrenius S
Article: LEUKEMIA. 2001;15(5):742-751
Granulocyte colony-stimulating factor inhibits Fas-triggered apoptosis in bone marrow cells isolated from patients with refractory anemia with ringed sideroblasts
Schmidt-Mende J; Tehranchi R; Forsblom AM; Joseph B; Christensson B; Fadeel B; Zhivotovsky B; Hellström-Lindberg E
Article: BRITISH JOURNAL OF HAEMATOLOGY. 2001;112(3):714-726
Apoptosis in refractory anaemia with ringed sideroblasts is initiated at the stem cell level and associated with increased activation of caspases
Lindberg EH; Schmidt-Mende J; Forsblom AM; Christensson B; Fadeel B; Zhivotovsky B
Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 2001;77(3):309-317
High-LET radiation induces apoptosis in lymphoblastoid cell lines derived from ataxia-telangiectasia patients
Meijer AE; Ekedahl J; Joseph B; Castro J; Harms-Ringdahl M; Zhivotovsky B; Lewensohn R
Article: FEBS JOURNAL. 2001;268(1):186-191
A folding variant of human α-lactalbumin induces mitochondrial permeability transition in isolated mitochondria
Köhler C; Gogvadze V; Håkansson A; Svanborg C; Orrenius S; Zhivotovsky B
Article: JOURNAL OF CELL SCIENCE. 2000;113(24):4399-4411
Two waves of programmed cell death occur during formation and development of somatic embryos in the gymnosperm, Norway spruce
Filonova LH; Bozhkov PV; Brukhin VB; Daniel G; Zhivotovsky B; von Arnold S
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 2000;62(4):557-565
Antioxidants J811 and 17β-estradiol protect cerebellar granule cells from methylmercury-induced apoptotic cell death
Daré E; Götz ME; Zhivotovsky B; Manzo L; Ceccatelli S
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 2000;245(1-2):91-94
Freezing induces artificial cleavage of apoptosis-related proteins in human bone marrow cells
Schmidt-Mende J; Hellström-Lindberg E; Joseph B; Zhivotovsky B
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2000;275(42):32438-32443
Distinct pathways for stimulation of cytochrome c release by etoposide
Robertson JD; Gogvadze V; Zhivotovsky B; Orrenius S
Article: FREE RADICAL BIOLOGY AND MEDICINE. 2000;29(3-4):334-342
Separation of cytochrome c-dependent caspase activation from thiol-disulfide redox change in cells lacking mitochondrial DNA
Cai JY; Wallace DC; Zhivotovsky B; Jones DP
Article: MEDICAL PRINCIPLES AND PRACTICE. 2000;9(3):151-163
The potential role of apoptosis in human disease
Fadeel B; Orrenius S; Zhivotovsky B
Article: CELL DEATH AND DIFFERENTIATION. 1999;6(11):1099-1108
Ultrarapid caspase-3 dependent apoptosis induction by serine/threonine phosphatase inhibitors
Fladmark KE; Brustugun OT; Hovland R; Boe R; Gjertsen BT; Zhivotovsky B; Doskeland SO
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;262(2):381-387
Differences in expression of pro-caspases in small cell and non-small cell lung carcinoma
Joseph B; Ekedahl J; Sirzen F; Lewensohn R; Zhivotovsky B
Article: EXPERIMENTAL HEMATOLOGY. 1999;27(8):1322-1329
Two pathways of apoptosis induced with all-trans retinoic acid and etoposide in the myeloid cell line P39
Hassan Z; Fadeel B; Zhivotovsky B; Hellström-Lindberg E
Article: JOURNAL OF IMMUNOLOGICAL METHODS. 1999;226(1-2):43-48
Application of a fluorometric assay to detect caspase activity in thymus tissue undergoing apoptosis in vivo
Gorman AM; Hirt UA; Zhivotovsky B; Orrenius S; Ceccatelli S
Article: EXPERIMENTAL CELL RESEARCH. 1999;249(2):260-268
Protease activation in apoptosis induced by MAL
Köhler C; Håkansson A; Svanborg C; Orrenius S; Zhivotovsky B
Article: INTERNATIONAL JOURNAL OF RADIATION BIOLOGY. 1999;75(6):709-716
Epstein-Barr virus-transformed lymphoblastoid cell lines of ataxia telangiectasia patients are defective in X-ray-induced apoptosis
Meijer AE; Zhivotovsky B; Lewensohn R
Article: JOURNAL OF NEUROSCIENCE RESEARCH. 1999;56(4):420-426
Radical scavenging compound J 811 inhibits hydrogen peroxide-induced death of cerebellar granule cells
Götz ME; Ahlbom E; Zhivotovsky B; Blum-Degen D; Oettel M; Römer W; Riederer P; Orrenius S; Ceccatelli S
Article: LEUKEMIA. 1999;13(5):719-728
Cleavage of Bcl-2 is an early event in chemotherapy-induced apoptosis of human myeloid leukemia cells
Fadeel B; Hassan Z; Hellström-Lindberg E; Henter JI; Orrenius S; Zhivotovsky B
Article: EMBO JOURNAL. 1999;18(8):2040-2048
Presence of a pre-apoptotic complex of pro-caspase-3, Hsp60 and Hsp10 in the mitochondrial fraction of Jurkat cells
Samali A; Cai JY; Zhivotovsky B; Jones DP; Orrenius S
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(4):1285-1291
Androgen treatment of neonatal rats decreases susceptibility of cerebellar granule neurons to oxidative stress in vitro
Ahlbom E; Grandison L; Bonfoco E; Zhivotovsky B; Ceccatelli S
Article: FEBS LETTERS. 1999;447(1):10-12
Release of adenylate kinase 2 from the mitochondrial intermembrane space during apoptosis
Köhler C; Gahm A; Noma T; Nakazawa A; Orrenius S; Zhivotovsky B
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 1999;11(3):1067-1072
Cytochrome c release and caspase-3 activation during colchicine-induced apoptosis of cerebellar granule cells
Gorman AM; Bonfoco E; Zhivotovsky B; Orrenius S; Ceccatelli S
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1999;255(1):6-11
A comparative study of apoptosis and necrosis in HepG2 cells: Oxidant-induced caspase inactivation leads to necrosis
Samali A; Nordgren H; Zhivotovsky B; Peterson E; Orrenius S
Article: EXPERIMENTAL CELL RESEARCH. 1999;246(2):451-460
Multimeric α-lactalbumin from human milk induces apoptosis through a direct effect on cell nuclei
Håkansson A; Andréasson J; Zhivotovsky B; Karpman D; Orrenius S; Svanborg C
Article: EUROPEAN JOURNAL OF CANCER. 1999;35(1):111-116
DNA-dependent protein kinase content and activity in lung carcinoma cell lines:: Correlation with intrinsic radiosensitivity
Sirzén F; Nilsson A; Zhivotovsky B; Lewensohn R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1998;273(50):33501-33507
Glucose and tolbutamide induce apoptosis in pancreatic β-cells - A process dependent on intracellular Ca²⁺ concentration
Efanova IB; Zaitsev SV; Zhivotovsky B; Köhler M; Efendic S; Orrenius S; Berggren PO
Article: LUNG CANCER. 1998;22(1):1-13
Higher spontaneous apoptotic index in small cell compared with non-small cell lung carcinoma cell lines;: lack of correlation with Bcl-2/Bax
Sirzén F; Zhivotovsky B; Nilsson A; Bergh J; Lewensohn R
Article: CELL DEATH AND DIFFERENTIATION. 1998;5(8):660-668
Apoptosis induced by microinjection of cytochrome c is caspase-dependent and is inhibited by Bcl-2
Brustugun OT; Fladmark KE; Doskeland SO; Orrenius S; Zhivotovsky B
Article: FEBS LETTERS. 1998;431(2):167-169
Detection of pro-caspase-3 in cytosol and mitochondria of various tissues
Samali A; Zhivotovsky B; Jones DP; Orrenius S
Article: ENDOCRINOLOGY. 1998;139(5):2465-2471
Termination of lactation induces apoptosis and alters the expression of the Bcl-2 family members in the rat anterior pituitary
Ahlbom E; Grandison L; Zhivotovsky B; Ceccatelli S
Article: ANTICANCER RESEARCH. 1998;18(2A):695-699
Spontaneous and radiation-induced apoptosis in lung carcinoma cells with different intrinsic radiosensitivities
Sirzén F; Zhivotovsky B; Nilsson A; Bergh J; Lewensohn R
Article: BIOCHEMICAL JOURNAL. 1998;329(Pt 1):95-99
Importance of the redox state of cytochrome c during caspase activation in cytosolic extracts
Hampton MB; Zhivotovsky B; Slater AFG; Burgess DH; Orrenius S
Article: NEUROREPORT. 1997;8(17):3779-3783
Apoptosis in rat hippocampal dentate gyrus after intraventricular colchicine
Ceccatelli S; Ahlbom E; Diana A; Zhivotovsky B
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 1997;10(6):636-643
Mechanism of dithiocarbamate inhibition of apoptosis: Thiol oxidation by dithiocarbamate disulfides directly inhibits processing of the caspase-3 proenzyme
Stefan C; Nobel I; Burgess DH; Zhivotovsky B; Burkitt MJ; Orrenius S; Slater AFG
Article: CELL DEATH AND DIFFERENTIATION. 1997;4(4):317-324
Inorganic mercury modifies Ca2+ signals, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons
Rossi AD; Viviani B; Zhivotovsky B; Manzo L; Orrenius S; Vahter M; Nicotera P
Article: EUROPEAN JOURNAL OF CANCER. 1997;33(6):942-949
Response to radiotherapy of human uterine cervix carcinoma is not correlated with rearrangements of the Ha-ras-1 and/or c-myc genes
Polischouk AG; Scotnikova OI; Sergeeva NS; Zharinov GM; Lewensohn R; Zhivotovsky B
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;233(1):96-101
Two different proteases are involved in the proteolysis of lamin during apoptosis
Zhivotovsky B; Gahm A; Orrenius S
Article: ATHEROSCLEROSIS. 1997;130(1-2):17-27
Cell death in human atherosclerotic plaques involves both oncosis and apoptosis
Crisby M; Kallin B; Thyberg J; Zhivotovsky B; Orrenius S; Kostulas V; Nilsson J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 1997;230(3):481-488
Involvement of cellular proteolytic machinery in apoptosis
Zhivotovsky B; Burgess DH; Vanags DM; Orrenius S
Article: CELL DEATH AND DIFFERENTIATION. 1997;4(1):39-50
The role of proteolysis in T cell apoptosis triggered by chelation of intracellular Zn2+
Jiang SN; Zhivotovsky B; Burgess DH; Gahm A; Chow SC; Orrenius S
Article: JOURNAL OF CELLULAR BIOCHEMISTRY. 1997;64(1):43-49
Proteases in Fas-mediated apoptosis
Zhivotovsky B; Burgess DH; Schlegel J; Porn MI; Vanags D; Orrenius S
Article: BRAIN RESEARCH BULLETIN. 1997;43(4):393-403
AMPA neurotoxicity in cultured cerebellar granule neurons: Mode of cell death
Cebers G; Zhivotovsky B; Ankarcrona M; Liljequist S
Article: NEUROREPORT. 1996;8(1):273-276
BCL-2 delay apoptosis and PARP cleavage induced by NO donors in GT1-7 cells
Bonfoco E; Zhivotovsky B; Rossi AD; AguilarSantelises M; Orrenius S; Lipton SA; Nicotera P
Article: JOURNAL OF NEUROCHEMISTRY. 1996;67(6):2484-2493
Cytoskeletal breakdown and apoptosis elicited by NO donors in cerebellar granule cells require NMDA receptor activation
Bonfoco E; Leist M; Zhivotovsky B; Orrenius S; Lipton SA; Nicotera P
Article: NEUROREPORT. 1996;7(15-17):2659-2664
Lamin and beta-tubulin fragmentation precede chromatin degradation in glutamate-induced neuronal apoptosis
Ankarcrona M; Zhivotovsky B; Holmstrom T; Diana A; Eriksson JE; Orrenius S; Nicotera P
Article: EXPERIMENTAL CELL RESEARCH. 1995;221(2):404-412
MULTIPLE PROTEASES ARE INVOLVED IN THYMOCYTE APOPTOSIS
ZHIVOTOVSKY B; GAHM A; ANKARCRONA M; NICOTERA P; ORRENIUS S
Article: NEURON. 1995;15(4):961-973
GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION
ANKARCRONA M; DYPBUKT JM; BONFOCO E; ZHIVOTOVSKY B; ORRENIUS S; LIPTON SA; NICOTERA P
Article: CARCINOGENESIS. 1995;16(10):2515-2521
CHARACTERIZATION OF HUMAN BUCCAL EPITHELIAL-CELLS TRANSFECTED WITH THE SIMIAN-VIRUS-40 T-ANTIGEN GENE
KULKARNI PS; SUNDQVIST K; BETSHOLTZ C; HOGLUND P; WIMAN KG; ZHIVOTOVSKY B; BERTOLERO F; LIU Y; GRAFSTROM RC
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1995;92(17):8064-8068
APOPTOSIS INDUCED BY A HUMAN-MILK PROTEIN
HAKANSSON A; ZHIVOTOVSKY B; ORRENIUS S; SABHARWAL H; SVANBORG C
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Professor Emeritus/Emerita, Institutet för miljömedicin, Karolinska Institutet, 2023-2025

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Docent, Inriktning toxikologi, Karolinska Institutet, 1997

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