Bernhard Lohkamp

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Artiklar

Article: BIOMOLECULES. 2023;13(12):1763
The Allosteric Regulation of Β-Ureidopropionase Depends on Fine-Tuned Stability of Active-Site Loops and Subunit Interfaces
Cederfelt D; Badgujar D; Musse AA; Lohkamp B; Danielson UH; Dobritzsch D
Article: ACTA CRYSTALLOGRAPHICA SECTION D: STRUCTURAL BIOLOGY. 2023;79(Pt 6):449-461
The CCP4 suite: integrative software for macromolecular crystallography
Agirre J; Atanasova M; Bagdonas H; Ballard CB; Basle A; Beilsten-Edmands J; Borges RJ; Brown DG; Burgos-Marmol JJ; Berrisford JM; Bond PS; Caballero I; Catapano L; Chojnowski G; Cook AG; Cowtan KD; Croll TI; Debreczeni JE; Devenish NE; Dodson EJ; Drevon TR; Emsley P; Evans G; Evans PR; Fando M; Foadi J; Fuentes-Montero L; Garman EF; Gerstel M; Gildea RJ; Hatti K; Hekkelman ML; Heuser P; Hoh SW; Hough MA; Jenkins HT; Jimenez E; Joosten RP; Keegan RM; Keep N; Krissinel EB; Kolenko P; Kovalevskiy O; Lamzin VS; Lawson DM; Lebedev AA; Leslie AGW; Lohkamp B; Long F; Maly M; McCoy AJ; McNicholas SJ; Medina A; Millan C; Murray JW; Murshudov GN; Nicholls RA; Noble MEM; Oeffner R; Pannu NS; Parkhurst JM; Pearce N; Pereira J; Perrakis A; Powell HR; Read RJ; Rigden DJ; Rochira W; Sammito M; Rodriguez FS; Sheldrick GM; Shelley KL; Simkovic F; Simpkin AJ; Skubak P; Sobolev E; Steiner RA; Stevenson K; Tews I; Thomas JMH; Thorn A; Trivino Valls J; Uski V; Uson I; Vagin A; Velankar S; Vollmar M; Walden H; Waterman D; Wilson KS; Winn MD; Winter G; Wojdyr M; Yamashita K
Article: ACTA CRYSTALLOGRAPHICA SECTION D: STRUCTURAL BIOLOGY. 2022;78(Pt 9):1079-1089
CCP4 Cloud for structure determination and project management in macromolecular crystallograpny
Krissinel E; Lebedev AA; Uski V; Ballard CB; Keegan RM; Kovalevskiy O; Nicholls RA; Pannu NS; Skubak P; Berrisford J; Fando M; Lohkamp B; Wojdyr M; Simpkin AJ; Thomas JMH; Oliver C; Vonrhein C; Chojnowski G; Basle A; Purkiss A; Isupov MN; McNicholas S; Lowe E; Trivino J; Cowtan K; Agirre J; Rigden DJ; Uson I; Lamzin V; Tews I; Bricogne G; Leslie AGW; Brown DG
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2021;108(5):951-961
Missense variants in DPYSL5 cause a neurodevelopmental disorder with corpus callosum agenesis and cerebellar abnormalities
Jeanne M; Demory H; Moutal A; Vuillaume M-L; Blesson S; Thepault R-A; Marouillat S; Halewa J; Maas SM; Motazacker MM; Mancini GMS; van Slegtenhorst MA; Andreou A; Cox H; Vogt J; Laufman J; Kostandyan N; Babikyan D; Hancarova M; Bendova S; Sedlacek Z; Aldinger KA; Sherr EH; Argilli E; England EM; Audebert-Bellanger S; Bonneau D; Colin E; Denomme-Pichon A-S; Gilbert-Dussardier B; Isidor B; Kury S; Odent S; Redon R; Khanna R; Dobyns WB; Bezieau S; Honnorat J; Lohkamp B; Toutain A; Laumonnier F
Article: PROTEIN SCIENCE. 2020;29(4):1069-1078
Current developments in Coot for macromolecular model building of Electron Cryo-microscopy and Crystallographic Data
Casanal A; Lohkamp B; Emsley P
Article: BIOCHEMICAL JOURNAL. 2018;475(14):2395-2416
Crystal structure and pH-dependent allosteric regulation of human β-ureidopropionase, an enzyme involved in anticancer drug metabolism
Maurer D; Lohkamp B; Krumpel M; Widersten M; Dobritzsch D
Article: JOURNAL OF PHYSICAL CHEMISTRY LETTERS. 2018;9(14):4082-4086
Mass Spectrometry Reveals the Direct Action of a Chemical Chaperone
Gault J; Lianoudaki D; Kaldmae M; Kronqvist N; Rising A; Johansson J; Lohkamp B; Lain S; Allison TM; Lane DP; Marklund EG; Landreh M
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(14):3637-3641
Ab initio solution of macromolecular crystal structures without direct methods
McCoy AJ; Oeffner RD; Wrobel AG; Ojala JRM; Tryggvason K; Lohkamp B; Read RJ
Article: PLOS ONE. 2015;10(3):e0121494
Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis
Poyraz O; Brunner K; Lohkamp B; Axelsson H; Hammarstrom LGJ; Schnell R; Schneider G
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2014;70(Pt 6):1680-1694
Crystal structure of human CRMP-4: correction of intensities for lattice-translocation disorder
Ponnusamy R; Lebedev AA; Pahlow S; Lohkamp B
Article: JOURNAL OF NEUROCHEMISTRY. 2013;125(6):855-868
Insights into the oligomerization of CRMPs: crystal structure of human collapsin response mediator protein 5
Ponnusamy R; Lohkamp B
Journal article: TIJDSCHRIFT VOOR KINDERGENEESKUNDE. 2013;81(Suppl 1):73-74
β-Ureidopropionase deficiency: phenotype, genotype and protein structural consequences in 16 patients
van Kuilenburg ABP; Dobritzsch D; Meijer J; Krumpel M; Selim LA; Rashed MS; Assmann B; Meinsma R; Lohkamp B; Ito T; Abeling NGGM; Saito K; Eto K; Smitka M; Engvall M; Zhang C; Xu W; Zoetekouw L; Hennekam RCM
Article: PEDIATRIC NEPHROLOGY. 2013;28(2):339-343
Novel INF2 mutation p. L77P in a family with glomerulopathy and Charcot-Marie-Tooth neuropathy
Rodriguez PQ; Lohkamp B; Celsi G; Mache CJ; Auer-Grumbach M; Wernerson A; Hamajima N; Tryggvason K; Patrakka J
Article: PLOS ONE. 2013;8(6):e66936
Substrate Channel Flexibility in Pseudomonas aeruginosa MurB Accommodates Two Distinct Substrates
Chen MW; Lohkamp B; Schnell R; Lescar J; Schneider G
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2012;1822(7):1096-1108
β-Ureidopropionase deficiency: Phenotype, genotype and protein structural consequences in 16 patients
van Kuilenburg ABP; Dobritzsch D; Meijer J; Krumpel M; Selim LA; Rashed MS; Assmann B; Meinsma R; Lohkamp B; Ito T; Abeling NGGM; Saito K; Eto K; Smitka M; Engvall M; Zhang C; Xu W; Zoetekouw L; Hennekam RCM
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2010;1804(12):2198-2206
Insights into the mechanism of dihydropyrimidine dehydrogenase from site-directed mutagenesis targeting the active site loop and redox cofactor coordination
Lohkamp B; Voevodskaya N; Lindqvist Y; Dobritzsch D
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2010;66(Pt 4):486-501
Features and development of Coot
Emsley P; Lohkamp B; Scott WG; Cowtan K
Article: JOURNAL OF MOLECULAR BIOLOGY. 2008;377(5):1544-1559
The crystal structure of β-alanine synthase from Drosophila melanogaster reveals a homooctameric helical turn-like assembly
Lundgren S; Lohkamp B; Andersen B; Piskur J; Dobritzsch D
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2008;64(Pt 4):407-415
A mixture of fortunes:: the curious determination of the structure of Escherichia coli BL21 Gab protein
Lohkamp B; Dobritzsch D
Article: MOLECULAR GENETICS AND METABOLISM. 2007;91(2):157-164
Clinical, biochemical and genetic findings in two siblings with a dihydropyrimidinase deficiency
van Kuilenburg ABP; Meijer J; Dobritzsch D; Meinsma R; Duran M; Lohkamp B; Zoetekouw L; Abeling NGGM; van Tinteren HLG; Bosch AM
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;362(3):555-566
Three-dimensional structure of iminodisuccinate epimerase defines the fold of the MmgE/PrpD protein family
Lohkamp B; Baeuerle B; Rieger P-G; Schneider G
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2006;155(1):111-113
Application of a new vector system for efficient protein purification in the crystallization of PA5104/ORF from Pseudomonas aeruginosa
Lohkamp B; Paterson NG; Lapthorn AJ
Article: JOURNAL OF MOLECULAR BIOLOGY. 2006;359(3):728-740
Crystal structures of SnoaL2 and AcIR:: Two putative hydroxylases in the biosynthesis of aromatic polyketide antibiotics
Beinker P; Lohkamp B; Peltonen T; Niemi J; Mantsala P; Schneider G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2006;281(19):13762-13776
The crystal structures of dihydropyrimidinases reaffirm the close relationship between cyclic amidohydrolases and explain their substrate specificity
Lohkamp B; Andersen B; Piskur J; Dobritzsch D
Article: ACTA CRYSTALLOGRAPHICA SECTION F: STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS. 2006;62(Pt 1):36-38
Purification, crystallization and X-ray diffraction analysis of dihydropyrimidinase from Dictyostelium discoideum
Lohkamp B; Andersen B; Piskur J; Dobritzsch D
Article: JOURNAL OF MOLECULAR BIOLOGY. 2004;336(1):131-144
The structure of Escherichia coli ATP-phosphoribosyltransferase:: Identification of substrate binding sites and mode of AMP inhibition
Lohkamp B; McDermott G; Campbell SA; Coggins JR; Lapthorn AJ
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2001;276(23):19954-19958
The allosteric effector L-lactate induces a conformational change of 2x6-meric lobster hemocyanin in the oxy state as revealed by small angle x-ray scattering
Hartmann H; Lohkamp B; Hellmann N; Decker H
Article: ACTA CRYSTALLOGRAPHICA SECTION D: BIOLOGICAL CRYSTALLOGRAPHY. 2000;56(Pt 11):1488-1491
Purification, crystallization and preliminary X-ray crystallographic analysis of ATP-phosphoribosyltransferase from Escherichia coli
Lohkamp B; Coggins JR; Lapthorn AJ
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Alla övriga publikationer

Corrigendum: PLOS ONE. 2015;10(4):e0127016
Crystal Structures of the Kinase Domain of the Sulfate-Activating Complex in Mycobacterium tuberculosis (vol 10, e0121494, 2015)
Poyraz O; Brunner K; Lohkamp B; Axelsson H; Hammarstroem LGJ; Schnell R
Book chapter: 2012;p. 443-447
Macromolecular model building and validation using Coot
Emsley P; Lohkamp B; Cowtan K
Published conference paper: NUCLEOSIDES, NUCLEOTIDES AND NUCLEIC ACIDS. 2008;27(6-7):809-815
Identification of two novel mutations C79X and R235Q in the dihydropyrimidine dehydrogenase gene in a patient presenting with hematuria
van Kuilenburg ABP; Meijer J; Dobritzsch D; Lohkamp B; Ruitenbeek W; Roelofsen J; Abeling NGGM; Duran M; Buzing C

Forskningsbidrag

Pushing the limits: Getting more information out of macromolecular structures
Swedish Research Council
1 January 2013 - 31 December 2014
Structural studies on the enzymes of histidine biosynthesis from pathogenic organisms.
Wellcome Trust
1 October 1999 - 30 September 2002

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