Ashish Kumar

Publikationer
Populärvetenskap och samverkan

Artiklar

Article: G3: GENES, GENOMES, GENETICS. 2024;14(8):jkae116
The genetic architecture of dog ownership: large-scale genome-wide association study in 97,552 European-ancestry individuals
Gong T; Karlsson R; Yao S; Magnusson PKE; Ajnakina O; Steptoe A; Bhatta L; Brumpton B; Kumar A; Melen E; Lin K-H; Tian C; Fall T; Almqvist C
Article: NATURE COMMUNICATIONS. 2023;14(1):6172
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
Budu-Aggrey A; Kilanowski A; Sobczyk MK; Shringarpure SS; Mitchell R; Reis K; Reigo A; Maegi R; Nelis M; Tanaka N; Brumpton BM; Thomas LF; Sole-Navais P; Flatley C; Espuela-Ortiz A; Herrera-Luis E; Lominchar JVT; Bork-Jensen J; Marenholz I; Arnau-Soler A; Jeong A; Fawcett KA; Baurecht H; Rodriguez E; Alves AC; Kumar A; Sleiman PM; Chang X; Medina-Gomez C; Hu C; Xu C-J; Qi C; El-Heis S; Titcombe P; Antoun E; Fadista J; Wang CA; Thiering E; Wu B; Kress S; Kothalawala DM; Kadalayil L; Duan J; Zhang H; Hadebe S; Hoffmann T; Jorgenson E; Choquet H; Risch N; Njolstad P; Andreassen OA; Johansson S; Almqvist C; Gong T; Ullemar V; Karlsson R; Magnusson PKE; Szwajda A; Burchard EG; Thyssen JP; Hansen T; Karhus LL; Dantoft TM; Jeanrenaud ACSN; Ghauri A; Arnold A; Homuth G; Lau S; Noethen MM; Huebner N; Imboden M; Visconti A; Falchi M; Bataille V; Hysi P; Ballardini N; Boomsma DI; Hottenga JJ; Mueller-Nurasyid M; Ahluwalia TS; Stokholm J; Chawes B; Schoos A-MM; Esplugues A; Bustamante M; Raby B; Arshad S; German C; Esko T; Milani LA; Metspalu A; Terao C; Abuabara K; Loset M; Hveem K; Jacobsson B; Pino-Yanes M; Strachan DP; Grarup N; Linneberg A; Lee Y-A; Probst-Hensch N; Weidinger S; Jarvelin M-R; Melen E; Hakonarson H; Irvine AD; Jarvis D; Nijsten T; Duijts L; Vonk JM; Koppelmann GH; Godfrey KM; Barton SJ; Feenstra B; Pennell CE; Sly PD; Holt PG; Williams LK; Bisgaard H; Bonnelykke K; Curtin J; Simpson A; Murray C; Schikowski T; Bunyavanich S; Weiss ST; Holloway JW; Min JL; Brown SJ; Standl M; Paternoster L
Article: CLINICAL EPIGENETICS. 2023;15(1):148
Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude
Kadalayil L; Alam MZ; White CH; Ghantous A; Walton E; Gruzieva O; Merid SK; Kumar A; Roy RP; Solomon O; Huen K; Eskenazi B; Rzehak P; Grote V; Langhendries J-P; Verduci E; Ferre N; Gruszfeld D; Gao L; Guan W; Zeng X; Schisterman EF; Dou JF; Bakulski KM; Feinberg JI; Soomro MH; Pesce G; Baiz N; Isaevska E; Plusquin M; Vafeiadi M; Roumeliotaki T; Langie SAS; Standaert A; Allard C; Perron P; Bouchard L; van Meel ER; Felix JF; Jaddoe VWV; Yousefi PD; Ramlau-Hansen CH; Relton CL; Tobi EW; Starling AP; Yang IV; Llambrich M; Santorelli G; Lepeule J; Salas LA; Bustamante M; Ewart SL; Zhang H; Karmaus W; Roeder S; Zenclussen AC; Jin J; Nystad W; Page CM; Magnus M; Jima DD; Hoyo C; Maguire RL; Kvist T; Czamara D; Raikkonen K; Gong T; Ullemar V; Rifas-Shiman SL; Oken E; Almqvist C; Karlsson R; Lahti J; Murphy SK; Haberg SE; London S; Herberth G; Arshad H; Sunyer J; Grazuleviciene R; Dabelea D; Steegers-Theunissen RPM; Nohr EA; Sorensen TIA; Duijts L; Hivert M-F; Nelen V; Popovic M; Kogevinas M; Nawrot TS; Herceg Z; Annesi-Maesano I; Fallin MD; Yeung E; Breton CV; Koletzko B; Holland N; Wiemels JL; Melen E; Sharp GC; Silver MJ; Rezwan FI; Holloway JW
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;78(3):836-850
Allergic disease trajectories up to adolescence: Characteristics, early-life, and genetic determinants
Kilanowski A; Thiering E; Wang G; Kumar A; Kress S; Flexeder C; Bauer C-P; Berdel D; von Berg A; Bergstroem A; Gappa M; Heinrich J; Herberth G; Koletzko S; Kull I; Melen E; Schikowski T; Peters A; Standl M
Article: NATURE GENETICS. 2021;53(9):1311-1321
Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
Min JL; Hemani G; Hannon E; Dekkers KF; Castillo-Fernandez J; Luijk R; Carnero-Montoro E; Lawson DJ; Burrows K; Suderman M; Bretherick AD; Richardson TG; Klughammer J; Iotchkova V; Sharp G; Al Khleifat A; Shatunov A; Iacoangeli A; McArdle WL; Ho KM; Kumar A; Soderhall C; Soriano-Tarraga C; Giralt-Steinhauer E; Kazmi N; Mason D; McRae AF; Corcoran DL; Sugden K; Kasela S; Cardona A; Day FR; Cugliari G; Viberti C; Guarrera S; Lerro M; Gupta R; Bollepalli S; Mandaviya P; Zeng Y; Clarke T-K; Walker RM; Schmoll V; Czamara D; Ruiz-Arenas C; Rezwan FI; Marioni RE; Lin T; Awaloff Y; Germain M; Aissi D; Zwamborn R; van Eijk K; Dekker A; van Dongen J; Hottenga J-J; Willemsen G; Xu C-J; Barturen G; Catala-Moll F; Kerick M; Wang C; Melton P; Elliott HR; Shin J; Bernard M; Yet I; Smarts M; Gorrie-Stone T; Shaw C; Al Chalabi A; Ring SM; Pershagen G; Melen E; Jimenez-Conde J; Roquer J; Lawlor DA; Wright J; Martin NG; Montgomery GW; Moffitt TE; Poulton R; Esko T; Milani L; Metspalu A; Perry JRB; Ong KK; Wareham NJ; Matullo G; Sacerdote C; Panico S; Caspi A; Arseneault L; Gagnon F; Ollikainen M; Kaprio J; Felix JF; Rivadeneira F; Tiemeier H; van IJzendoorn MH; Uitterlinden AG; Jaddoe VWV; Hale C; McIntosh AM; Evans KL; Murray A; Raikkonen K; Lahti J; Nohr EA; Sorensen TIA; Hansen T; Morgen CS; Binder EB; Lucae S; Gonzalez JR; Bustamante M; Sunyer J; Holloway JW; Karmaus W; Zhang H; Deary IJ; Wray NR; Starr JM; Beekman M; VanHeemst D; Slagboom PE; Morange P-E; Tregouet D-A; Veldink JH; Davies GE; de Geus EJC; Boomsma DI; Vonk JM; Brunekreef B; Koppelman GH; Alarcon-Riquelme ME; Huang R-C; Pennell CE; van Meurs J; Ikram MA; Hughes AD; Tillin T; Chaturvedi N; Pausova Z; Paus T; Spector TD; Kumari M; Schalkwyk LC; Visscher PM; Smith GD; Bock C; Gaunt TR; Bell JT; Heijmans BT; Mill J; Relton CL
Article: GENOME MEDICINE. 2020;12(1):25
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.
Merid SK; Novoloaca A; Sharp GC; Küpers LK; Kho AT; Roy R; Gao L; Annesi-Maesano I; Jain P; Plusquin M; Kogevinas M; Allard C; Vehmeijer FO; Kazmi N; Salas LA; Rezwan FI; Zhang H; Sebert S; Czamara D; Rifas-Shiman SL; Melton PE; Lawlor DA; Pershagen G; Breton CV; Huen K; Baiz N; Gagliardi L; Nawrot TS; Corpeleijn E; Perron P; Duijts L; Nohr EA; Bustamante M; Ewart SL; Karmaus W; Zhao S; Page CM; Herceg Z; Jarvelin M-R; Lahti J; Baccarelli AA; Anderson D; Kachroo P; Relton CL; Bergström A; Eskenazi B; Soomro MH; Vineis P; Snieder H; Bouchard L; Jaddoe VW; Sørensen TIA; Vrijheid M; Arshad SH; Holloway JW; Håberg SE; Magnus P; Dwyer T; Binder EB; DeMeo DL; Vonk JM; Newnham J; Tantisira KG; Kull I; Wiemels JL; Heude B; Sunyer J; Nystad W; Munthe-Kaas MC; Räikkönen K; Oken E; Huang R-C; Weiss ST; Antó JM; Bousquet J; Kumar A; Söderhäll C; Almqvist C; Cardenas A; Gruzieva O; Xu C-J; Reese SE; Kere J; Brodin P; Solomon O; Wielscher M; Holland N; Ghantous A; Hivert M-F; Felix JF; Koppelman GH; London SJ; Melén E
Journal article: GENOME MEDICINE. 2020;12:1-17
Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age
Merid SK; Novoloaca A; Sharp GC; Küpers LK; Kho AT; Roy R; Gao L; Annesi-Maesano I; Jain P; Plusquin M; others
Journal article: MEDRXIV. 2020;:2020-09
Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
Min JL; Hemani G; Hannon E; Dekkers KF; Castillo-Fernandez J; Luijk R; Carnero-Montoro E; Lawson DJ; Burrows K; Suderman M; others
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2019;144(3):857-860.e7
Genetic risk scores do not improve asthma prediction in childhood
Dijk EN; Folkersma C; Gruzieva O; Kumar A; Wijga AH; Gehring U; Kull I; Postma DS; Vonk JM; Melen E; Koppelman GH
Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY (EJE). 2019;34(3):279-300
The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia: design, results and future prospects
Middeldorp CM; Mahajan A; Horikoshi M; Robertson NR; Beaumont RN; Bradfield JP; Bustamante M; Cousminer DL; Day FR; De Silva NM; Guxens M; Mook-Kanamori DO; St Pourcain B; Warrington NM; Adair LS; Ahlqvist E; Ahluwalia TS; Almgren P; Ang W; Atalay M; Auvinen J; Bartels M; Beckmann JS; Bilbao JR; Bond T; Borja JB; Cavadino A; Charoen P; Chen Z; Coin L; Cooper C; Curtin JA; Custovic A; Das S; Davies GE; Dedoussis GV; Duijts L; Eastwood PR; Eliasen AU; Elliott P; Eriksson JG; Estivill X; Fadista J; Fedko IO; Frayling TM; Gaillard R; Gauderman WJ; Geller F; Gilliland F; Gilsanz V; Granell R; Grarup N; Groop L; Hadley D; Hakonarson H; Hansen T; Hartman CA; Hattersley AT; Hayes MG; Hebebrand J; Heinrich J; Helgeland O; Henders AK; Henderson J; Henriksen TB; Hirschhorn JN; Hivert M-F; Hocher B; Holloway JW; Holt P; Hottenga J-J; Hypponen E; Iniguez C; Johansson S; Jugessur A; Kahonen M; Kalkwarf HJ; Kaprio J; Karhunen V; Kemp JP; Kerkhof M; Koppelman GH; Korner A; Kotecha S; Kreiner-Moller E; Kulohoma B; Kumar A; Kutalik Z; Lahti J; Lappe JM; Larsson H; Lehtimaki T; Lewin AM; Li J; Lichtenstein P; Lindgren CM; Lindi V; Linneberg A; Liu X; Liu J; Lowe WLJ; Lundstrom S; Lyytikainen L-P; Ma RCW; Mace A; Magi R; Magnus P; Mamun AA; Mannikko M; Martin NG; Mbarek H; McCarthy NS; Medland SE; Melbye M; Melen E; Mohlke KL; Monnereau C; Morgen CS; Morris AP; Murray JC; Myhre R; Najman JM; Nivard MG; Nohr EA; Nolte IM; Ntalla I; O'Reilly P; Oberfield SE; Oken E; Oldehinkel AJ; Pahkala K; Palviainen T; Panoutsopoulou K; Pedersen O; Pennell CE; Pershagen G; Pitkanen N; Plomin R; Power C; Prasad RB; Prokopenko I; Pulkkinen L; Raikkonen K; Raitakari OT; Reynolds RM; Richmond RC; Rivadeneira F; Rodriguez A; Rose RJ; Salem R; Santa-Marina L; Saw S-M; Schnurr TM; Scott JG; Selzam S; Shepherd JA; Simpson A; Skotte L; Sleiman PMA; Snieder H; Sorensen TIA; Standl M; Steegers EAP; Strachan DP; Straker L; Strandberg T; Taylor M; Teo Y-Y; Thiering E; Torrent M; Tyrrell J; Uitterlinden AG; van Beijsterveldt T; van der Most PJ; van Duijn CM; Viikari J; Vilor-Tejedor N; Vogelezang S; Vonk JM; Vrijkotte TGM; Vuoksimaa E; Wang CA; Watkins WJ; Wichmann H-E; Willemsen G; Williams GM; Wilson JF; Wray NR; Xu S; Xu C-J; Yaghootkar H; Yi L; Zafarmand MH; Zeggini E; Zemel BS; Hinney A; Lakka TA; Whitehouse AJO; Sunyer J; Widen EE; Feenstra B; Sebert S; Jacobsson B; Njolstad PR; Stoltenberg C; Smith GD; Lawlor DA; Paternoster L; Timpson NJ; Ong KK; Bisgaard H; Bonnelykke K; Jaddoe VWV; Tiemeier H; Jarvelin M-R; Evans DM; Perry JRB; Grant SFA; Boomsma DI; Freathy RM; McCarthy MI; Felix JF
Journal article: NATURE. 2019;570:71-76
Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls
Flannick J; Mercader JM; Fuchsberger C; Udler MS; Mahajan A; Wessel J; Teslovich TM; Caulkins L; Koesterer R; Barajas-Olmos F; others
Article: NATURE GENETICS. 2018;50(8):1072-1080
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
Waage J; Standl M; Curtin JA; Jessen LE; Thorsen J; Tian C; Schoettler N; Flores C; Abdellaoui A; Ahluwalia TS; Alves AC; Amaral AFS; Anto JM; Arnold A; Barreto-Luis A; Baurecht H; van Beijsterveldt CEM; Bleecker ER; Bonas-Guarch S; Boomsman DI; Brix S; Bunyavanich S; Burchard EG; Chen Z; Curjuric I; Custovic A; den Dekker HT; Dharmage SC; Dmitrieva J; Duijts L; Ege MJ; Gauderman WJ; Georges M; Gieger C; Gilliland F; Granell R; Gui H; Hansen T; Heinrich J; Henderson J; Hernandez-Pacheco N; Holt P; Imboden M; Jaddoe VWV; Jarvelin M-R; Jarvis DL; Jensen KK; Jonsdottir I; Kabesch M; Kaprio J; Kumar A; Lee Y-A; Levin AM; Li X; Lorenzo-Diaz F; Melen E; Mercader JM; Meyers DA; Myers R; Nicolae DL; Nohr EA; Palviainen T; Paternoster L; Pennell CE; Pershagen G; Pino-Yanes M; Probst-Hensch NM; Ruschendorf F; Simpson A; Stefansson K; Sunyer J; Sveinbjornsson G; Thiering E; Thompson PJ; Torrent M; Torrents D; Tung JY; Wang CA; Weidinger S; Weiss S; Willemsen G; Williams LK; Ober C; Hinds DA; Ferreira MA; Bisgaard H; Strachan DP; Bonnelykke K
Journal article: WELLCOME OPEN RESEARCH. 2018;3:4
Meta-analysis of exome array data identifies six novel genetic loci for lung function
Jackson VE; Latourelle JC; Wain LV; Smith AV; Grove ML; Bartz TM; Obeidat M; Province MA; Gao W; Qaiser B; Porteous DJ; Cassano PA; Ahluwalia TS; Grarup N; Li J; Altmaier E; Marten J; Harris SE; Manichaikul A; Pottinger TD; Li-Gao R; Lind-Thomsen A; Mahajan A; Lahousse L; Imboden M; Teumer A; Prins B; Lyytikäinen L-P; Eiriksdottir G; Franceschini N; Sitlani CM; Brody JA; Bossé Y; Timens W; Kraja A; Loukola A; Tang W; Liu Y; Bork-Jensen J; Justesen JM; Linneberg A; Lange LA; Rawal R; Karrasch S; Huffman JE; Smith BH; Davies G; Burkart KM; Mychaleckyj JC; Bonten TN; Enroth S; Lind L; Brusselle GG; Kumar A; Stubbe B; Kähönen M; Wyss AB; Psaty BM; Heckbert SR; Hao K; Rantanen T; Kritchevsky SB; Lohman K; Skaaby T; Pisinger C; Hansen T; Schulz H; Polasek O; Campbell A; Starr JM; Rich SS; Mook-Kanamori DO; Johansson Å; Ingelsson E; Uitterlinden AG; Weiss S; Raitakari OT; Gudnason V; North KE; Gharib SA; Sin DD; Taylor KD; O'Connor GT; Kaprio J; Harris TB; Pederson O; Vestergaard H; Wilson JG; Strauch K; Hayward C; Kerr S; Deary IJ; Barr RG; de Mutsert R; Gyllensten U; Morris AP; Ikram MA; Probst-Hensch N; Gläser S; Zeggini E; Lehtimäki T; Strachan DP; Dupuis J; Morrison AC; Hall IP; Tobin MD; London SJ
Article: THE LANCET RESPIRATORY MEDICINE. 2018;6(5):379-388
DNA methylation in childhood asthma: an epigenome-wide meta-analysis
Xu C-J; Soderhall C; Bustamante M; Baiz N; Gruzieva O; Gehring U; Mason D; Chatzi L; Basterrechea M; Llop S; Torrent M; Forastiere F; Fantini MP; Carlsen KCL; Haahtela T; Morin A; Kerkhof M; Merid SK; van Rijkom B; Jankipersadsing SA; Bonder MJ; Ballereau S; Vermeulen CJ; Aguirre-Gamboa R; de Jongste JC; Smit HA; Kumar A; Pershagen G; Guerra S; Garcia-Aymerich J; Greco D; Reinius L; McEachan RRC; Azad R; Hovland V; Mowinckel P; Alenius H; Fyhrquist N; Lemonnier N; Pellet J; Auffray C; van der Vlies P; van Diemen CC; Li Y; Wijmenga C; Netea MG; Moffatt MF; Cookson WOCM; Anto JM; Bousquet J; Laatikainen T; Laprise C; Carlsen K-H; Gori D; Porta D; Iniguez C; Bilbao JR; Kogevinas M; Wright J; Brunekreef B; Kere J; Nawijn MC; Annesi-Maesano I; Sunyer J; Melen E; Koppelman GH
Article: EUROPEAN RESPIRATORY JOURNAL. 2018;51(3):1701377
Genetic regulation of IL1RL1 methylation and IL1RL1-a protein levels in asthma
Dijk FN; Xu C; Melen E; Carsin A-E; Kumar A; Nolte IM; Gruzieva O; Pershagen G; Grotenboer NS; Savenije OEM; Maria Anto J; Lavi I; Dobano C; Bousquet J; van der Vlies P; van der Valk RJP; de Jongste JC; Nawijn MC; Guerra S; Postma DS; Koppelman GH
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2018;141(3):1105-1114
Genetic and epigenetic regulation of YKL-40 in childhood
Guerra S; Melen E; Sunyer J; Xu C-J; Lavi I; Benet M; Bustamante M; Carsin A-E; Dobano C; Guxens M; Tischer C; Vrijheid M; Kull I; Bergstrom A; Kumar A; Soderhall C; Gehring U; Dijkstra DJ; van der Vlies P; Wickman M; Bousquet J; Postma DS; Anto JM; Koppelman GH
Journal article: WELLCOME OPEN RESEARCH. 2018;3:4
Meta-analysis of exome array data identifies six novel genetic loci for lung function
Jackson VE; Latourelle JC; Wain LV; Smith AV; Grove ML; Bartz TM; Obeidat M; Province MA; Gao W; Qaiser B; Porteous DJ; Cassano PA; Ahluwalia TS; Grarup N; Li J; Altmaier E; Marten J; Harris SE; Manichaikul A; Pottinger TD; Li-Gao R; Lind-Thomsen A; Mahajan A; Lahousse L; Imboden M; Teumer A; Prins B; Lyytikäinen L-P; Eiriksdottir G; Franceschini N; Sitlani CM; Brody JA; Bossé Y; Timens W; Kraja A; Loukola A; Tang W; Liu Y; Bork-Jensen J; Justesen JM; Linneberg A; Lange LA; Rawal R; Karrasch S; Huffman JE; Smith BH; Davies G; Burkart KM; Mychaleckyj JC; Bonten TN; Enroth S; Lind L; Brusselle GG; Kumar A; Stubbe B; Kähönen M; Wyss AB; Psaty BM; Heckbert SR; Hao K; Rantanen T; Kritchevsky SB; Lohman K; Skaaby T; Pisinger C; Hansen T; Schulz H; Polasek O; Campbell A; Starr JM; Rich S; Mook-Kanamori DO; Johansson Å; Ingelsson E; Uitterlinden AG; Weiss S; Raitakari OT; Gudnason V; North KE; Gharib SA; Sin DD; Taylor KD; O'Connor GT; Kaprio J; Harris TB; Pederson O; Vestergaard H; Wilson JG; Strauch K; Hayward C; Kerr S; Deary I; Barr RG; de Mutsert R; Gyllensten U; Morris AP; Ikram MA; Probst-Hensch N; Gläser S; Zeggini E; Lehtimäki T; Strachan DP; Dupuis J; Morrison AC; Hall IP; Tobin MD; London SJ
Journal article: WELLCOME OPEN RESEARCH. 2018;3:4
Meta-analysis of exome array data identifies six novel genetic loci for lung function.
Jackson VE; Latourelle JC; Wain LV; Smith AV; Grove ML; Bartz TM; Obeidat M; Province MA; Gao W; Qaiser B; Porteous DJ; Cassano PA; Ahluwalia TS; Grarup N; Li J; Altmaier E; Marten J; Harris SE; Manichaikul A; Pottinger TD; Li-Gao R; Lind-Thomsen A; Mahajan A; Lahousse L; Imboden M; Teumer A; Prins B; Lyytikäinen L-P; Eiriksdottir G; Franceschini N; Sitlani CM; Brody JA; Bossé Y; Timens W; Kraja A; Loukola A; Tang W; Liu Y; Bork-Jensen J; Justesen JM; Linneberg A; Lange LA; Rawal R; Karrasch S; Huffman JE; Smith BH; Davies G; Burkart KM; Mychaleckyj JC; Bonten TN; Enroth S; Lind L; Brusselle GG; Kumar A; Stubbe B; Understanding Society Scientific Group; Kähönen M; Wyss AB; Psaty BM; Heckbert SR; Hao K; Rantanen T; Kritchevsky SB; Lohman K; Skaaby T; Pisinger C; Hansen T; Schulz H; Polasek O; Campbell A; Starr JM; Rich SS; Mook-Kanamori DO; Johansson Å; Ingelsson E; Uitterlinden AG; Weiss S; Raitakari OT; Gudnason V; North KE; Gharib SA; Sin DD; Taylor KD; O'Connor GT; Kaprio J; Harris TB; Pederson O; Vestergaard H; Wilson JG; Strauch K; Hayward C; Kerr S; Deary IJ; Barr RG; de Mutsert R; Gyllensten U; Morris AP; Ikram MA; Probst-Hensch N; Gläser S; Zeggini E; Lehtimäki T; Strachan DP; Dupuis J; Morrison AC; Hall IP; Tobin MD; London SJ
Journal article: SCIENTIFIC DATA. 2018;5:1-2
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick J; Fuchsberger C; Mahajan A; Teslovich TM; Agarwala V; Gaulton KJ; Caulkins L; Koesterer R; Ma C; Moutsianas L; others
Journal article: F1000RESEARCH. 2018;7:253
Meta-analysis of exome array data identifies six novel genetic loci for lung function
Cyr S; Black K-J; Munoz M; Grove ML; Bartz TM; Obeidat M; Province MA; Gao W; Qaiser B; Porteous DJ; others
Journal article: SCIENTIFIC DATA. 2018;5
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls (vol 4, 170179, 2017)
Flannick J; Fuchsberger C; Mahajan A; Teslovich TM; Agarwala V; Gaulton KJ; Caulkins L; Koesterer R; Ma C; Moutsianas L; others
Article: NATURE GENETICS. 2018;50(1):42-53
Multiancestry association study identifies new asthma risk loci that colocalize with immune-cell enhancer marks
Demenais F; Margaritte-Jeannin P; Barnes KC; Cookson WOC; Altmueller J; Ang W; Barr RG; Beaty TH; Becker AB; Beilby J; Bisgaard H; Bjornsdottir US; Bleecker E; Bonnelykke K; Boomsma DI; Bouzigon E; Brightling CE; Brossard M; Brusselle GG; Burchard E; Burkart KM; Bush A; Chan-Yeung M; Chung KF; Alves AC; Curtin JA; Custovic A; Daley D; de Jongste JC; Del-Rio-Navarro BE; Donohue KM; Duijts L; Eng C; Eriksson JG; Farrall M; Fedorova Y; Feenstra B; Ferreira MA; Freidin MB; Gajdos Z; Gauderman J; Gehring U; Geller F; Genuneit J; Gharib SA; Gilliland F; Granell R; Graves PE; Gudbjartsson DF; Haahtela T; Heckbert SR; Heederik D; Heinrich J; Heliovaara M; Henderson J; Himes BE; Hirose H; Hirschhorn JN; Hofman A; Holt P; Hottenga J; Hudson TJ; Hui J; Imboden M; Ivanov V; Jaddoe VWV; James A; Janson C; Jarvelin M-R; Jarvis D; Jones G; Jonsdottir I; Jousilahti P; Kabesch M; Kahonen M; Kantor DB; Karunas AS; Khusnutdinova E; Koppelman GH; Kozyrskyj AL; Kreiner E; Kubo M; Kumar R; Kumar A; Kuokkanen M; Lahousse L; Laitinen T; Laprise C; Lathrop M; Lau S; Lee Y-A; Lehtimaki T; Letort S; Levin AM; Li G; Liang L; Loehr LR; London SJ; Loth DW; Manichaikul A; Marenholz I; Martinez FJ; Matheson MC; Mathias RA; Matsumoto K; Mbarek H; McArdle WL; Melbye M; Melen E; Meyers D; Michel S; Mohamdi H; Musk AW; Myers RA; Nieuwenhuis MAE; Noguchi E; O'Connor GT; Ogorodova LM; Palmer CD; Palotie A; Park JE; Pennell CE; Pershagen G; Polonikov A; Postma DS; Probst-Hensch N; Puzyrev VP; Raby BA; Raitakari OT; Ramasamy A; Rich SS; Robertson CF; Romieu I; Salam MT; Salomaa V; Schlunssen V; Scott R; Selivanova PA; Sigsgaard T; Simpson A; Siroux V; Smith LJ; Solodilova M; Standl M; Stefansson K; Strachan DP; Stricker BH; Takahashi A; Thompson PJ; Thorleifsson G; Thorsteinsdottir U; Tiesler CMT; Torgerson DG; Tsunoda T; Uitterlinden AG; van der Valk RJP; Vaysse A; Vedantam S; von Berg A; von Mutius E; Vonk JM; Waage J; Wareham NJ; Weiss ST; White WB; Wickman M; Widen E; Willemsen G; Williams LK; Wouters IM; Yang JJ; Zhao JH; Moffatt MF; Ober C; Nicolae DL
Journal article: INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 2017;14(12):E1492-1492
Exposure to Night-Time Traffic Noise, Melatonin-Regulating Gene Variants and Change in Glycemia in Adults
Eze IC; Imboden M; Foraster M; Schaffner E; Kumar A; Vienneau D; Heritier H; Rudzik F; Thiesse L; Pieren R; von Eckardstein A; Schindler C; Brink M; Wunderli J-M; Cajochen C; Roosli M; Probst-Hensch N
Article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2017;195(10):1373-1383
Genome-Wide Interaction Analysis of Air Pollution Exposure and Childhood Asthma with Functional Follow-up
Gref A; Merid SK; Gruzieva O; Ballereau S; Becker A; Bellander T; Bergstrom A; Bosse Y; Bottai M; Chan-Yeung M; Fuertes E; Ierodiakonou D; Jiang R; Joly S; Jones M; Kobor MS; Korek M; Kozyrskyj AL; Kumar A; Lemonnier N; MacIntyre E; Menard C; Nickle D; Obeidat M; Pellet J; Standl M; Saaf A; Soderhall C; Tiesler CMT; van den Berge M; Vonk JM; Vora H; Xu C-J; Anto JM; Auffray C; Brauer M; Bousquet J; Brunekreef B; Gauderman WJ; Heinrich J; Kere J; Koppelman GH; Postma D; Carlsten C; Pershagen G; Melen E
Journal article: SCIENTIFIC REPORTS. 2017;7:45040
1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function
Gorski M; Van der Most PJ; Teumer A; Chu AY; Li M; Mijatovic V; Nolte IM; Cocca M; Taliun D; Gomez F; Li Y; Tayo B; Tin A; Feitosa MF; Aspelund T; Attia J; Biffar R; Bochud M; Boerwinkle E; Borecki I; Bottinger EP; Chen M-H; Chouraki V; Ciullo M; Coresh J; Cornelis MC; Curhan GC; d'Adamo AP; Dehghan A; Dengler L; Ding J; Eiriksdottir G; Endlich K; Enroth S; Esko T; Franco OH; Gasparini P; Gieger C; Girotto G; Gottesman O; Gudnason V; Gyllensten U; Hancock SJ; Harris TB; Helmer C; Hoellerer S; Hofer E; Hofman A; Holliday EG; Homuth G; Hu FB; Huth C; Hutri-Kahonen N; Hwang S-J; Imboden M; Johansson A; Kahonen M; Koenig W; Kraemer H; Kramer BK; Kumar A; Kutalik Z; Lambert J-C; Launer LJ; Lehtimaki T; de Borst M; Navis G; Swertz M; Liu Y; Lohman K; Loos RJF; Lu Y; Lyytikainen L-P; McEvoy MA; Meisinger C; Meitinger T; Metspalu A; Metzger M; Mihailov E; Mitchell P; Nauck M; Oldehinkel AJ; Olden M; Penninx BWJH; Pistis G; Pramstaller PP; Probst-Hensch N; Raitakari OT; Rettig R; Ridker PM; Rivadeneira F; Robino A; Rosas SE; Ruderfer D; Ruggiero D; Saba Y; Sala C; Schmidt H; Schmidt R; Scott RJ; Sedaghat S; Smith AV; Sorice R; Stengel B; Stracke S; Strauch K; Toniolo D; Uitterlinden AG; Ulivi S; Viikari JS; Voelker U; Vollenweider P; Voelzke H; Vuckovic D; Waldenberger M; Wang JJ; Yang Q; Chasman DI; Tromp G; Snieder H; Heid IM; Fox CS; Koettgen A; Pattaro C; Boeger CA; Fuchsberger C
Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2017;28(3):981-994
SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
Li M; Li Y; Weeks O; Mijatovic V; Teumer A; Huffman JE; Tromp G; Fuchsberger C; Gorski M; Lyytikainen L-P; Nutile T; Sedaghat S; Sorice R; Tin A; Yang Q; Ahluwalia TS; Arking DE; Bihlmeyer NA; Boeger CA; Carroll RJ; Chasman DI; Comelis MC; Dehghan A; Faul JD; Feitosa MF; Gambaro G; Gasparini P; Giulianini F; Heid I; Huang J; Imboden M; Jackson AU; Jeff J; Jhun MA; Katz R; Kifley A; Kilpelainen T; Kumar A; Laakso M; Li-Gao R; Lohman K; Lu Y; Maegi R; Malerba G; Mihailov E; Mohlke KL; Mook-Kanamori DO; Robino A; Ruderfer D; Salvi E; Schick UM; Schulz C-A; Smith AV; Smith JA; Traglia M; Yerges-Armstrong LM; Zhao W; Goodarzi MO; Kraja AT; Liu C; Wessel J; Boerwinkle E; Borecki IB; Bork-Jensen J; Bottinger EP; Braga D; Brandslund I; Brody JA; Campbell A; Carey DJ; Christensen C; Coresh J; Crook E; Curhan GC; Cusi D; de Boer IH; de Vries APJ; Denny JC; Devuyst O; Dreisbach AW; Endlich K; Esko T; Franco OH; Fulop T; Gerhard GS; Gluemer C; Gottesman O; Grarup N; Gudnason V; Hansen T; Harris TB; Hayward C; Hocking L; Hofman A; Hu FB; Husemoen LLN; Jackson RD; Jorgensen T; Jorgensen ME; Kaehoenen M; Kardia SLR; Koenig W; Kooperberg C; Kriebel J; Launer LJ; Lauritzen T; Lehtimaki T; Levy D; Linksted P; Linneberg A; Liu Y; Loos RJF; Lupo A; Meisinger C; Melander O; Metspalu A; Mitchell P; Nauck M; Nuernberg P; Orho-Melander M; Parsa A; Pedersen O; Peters A; Peters U; Polasek O; Porteous D; Probst-Hensch NM; Psaty BM; Qi L; Raitakari OT; Reiner AP; Rettig R; Ridker PM; Rivadeneira F; Rossouw JE; Schmidt F; Siscovick D; Soranzo N; Strauch K; Toniolo D; Turner ST; Uitterlinden AG; Ulivi S; Velayutham D; Voelker U; Volzke H; Waldenberger M; Wang JJ; Weir DR; Witte D; Kuivaniemi H; Fox CS; Franceschini N; Goessling W; Koettgen A; Chu AY
Journal article: 2017
A Low-Frequency Inactivating Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning A; Highland HM; Gasser J; Sim X; Tukiainen T; Fontanillas P; Grarup N; Rivas MA; Mahajan A; Locke AE; others
Journal article: DIABETES. 2017;66:2019-2032
A low-frequency inactivating AKT2 variant enriched in the Finnish population is associated with fasting insulin levels and type 2 diabetes risk
Manning A; Highland HM; Gasser J; Sim X; Tukiainen T; Fontanillas P; Grarup N; Rivas MA; Mahajan A; Locke AE; others
Journal article: PLOS ONE. 2017;12:e0172716
Adult onset asthma and interaction between genes and active tobacco smoking: The GABRIEL consortium
Vonk JM; Scholtens S; Postma DS; Moffatt MF; Jarvis D; Ramasamy A; Wjst M; Omenaas ER; Bouzigon E; Demenais F; others
Journal article: SCIENTIFIC DATA. 2017;4:1-22
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick J; Fuchsberger C; Mahajan A; Teslovich TM; Agarwala V; Gaulton KJ; Caulkins L; Koesterer R; Ma C; Moutsianas L; others
Article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2017;125(1):104-110
Epigenome-Wide Meta-Analysis of Methylation in Children Related to Prenatal NO₂ Air Pollution Exposure
Gruzieva O; Xu C-J; Breton CV; Annesi-Maesano I; Anto JM; Auffray C; Ballereau S; Bellander T; Bousquet J; Bustamante M; Charles M-A; de Kluizenaar Y; den Dekker HT; Duijts L; Felix JF; Gehring U; Guxens M; Jaddoe VVW; Jankipersadsing SA; Merid SK; Kere J; Kumar A; Lemonnier N; Lepeule J; Nystad W; Page CM; Panasevich S; Postma D; Slama R; Sunyer J; Soderhall C; Yao J; London SJ; Pershagen G; Koppelman GH; Melen E
Journal article: ENVIRONMENT INTERNATIONAL. 2016;94:263-271
Air pollution and diabetes association: Modification by type 2 diabetes genetic risk score
Eze IC; Imboden M; Kumar A; von Eckardstein A; Stolz D; Gerbase MW; Kunzli N; Pons M; Kronenberg F; Schindler C; Probst-Hensch N
Journal article: AGE. 2016;38(3):52
Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline
Curjuric I; Imboden M; Bridevaux P-O; Gerbase MW; Haun M; Keidel D; Kumar A; Pons M; Rochat T; Schikowski T; Schindler C; von Eckardstein A; Kronenberg F; Probst-Hensch NM
Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2016;98(4):680-696
DNA Methylation in Newborns and Maternal Smoking in Pregnancy: Genome-wide Consortium Meta-analysis
Joubert BR; Felix JF; Yousefi P; Bakulski KM; Just AC; Breton C; Reese SE; Markunas CA; Richmond RC; Xu C-J; Kupers LK; Oh SS; Hoyo C; Gruzieva O; Soderhal C; Salas LA; Baiz N; Zhang H; Lepeule J; Ruiz C; Ligthart S; Wang T; Taylor JA; Duijts L; Sharp GC; Jankipersadsing SA; Nilsen RM; Vaez A; Fallin MD; Hu D; Litonjua AA; Fuemmeler BF; Huen K; Kere J; Kull I; Munthe-Kaas MC; Gehring U; Bustamante M; Saurel-Coubizolles MJ; Quraishi BM; Ren J; Tost J; Gonzalez JR; Peters MJ; Haberg SE; Xu Z; van Meurs JB; Gaunt TR; Kerkhof M; Corpeleijn E; Feinberg AP; Eng C; Baccarelli AA; Neelon SEB; Bradman A; Merid SK; Bergstrom A; Herceg Z; Hernandez-Vargas H; Brunekreef B; Pinart M; Heude B; Ewart S; Yao J; Lemonnier N; Franco OH; Wu MC; Hofman A; McArdle W; Van der Vlies P; Falahi F; Gillman MW; Barcellos LF; Kumar A; Wickman M; Guerra S; Charles M-A; Holloway J; Auffray C; Tiemeier HW; Smith GD; Postma D; Hivert M-F; Eskenazi B; Vrijheid M; Arshad H; Anto JM; Dehghan A; Karmaus W; Annesi-Maesano I; Sunyer J; Ghantous A; Pershagen G; Hollands N; Murphy SK; DeMeo DL; Burchard EG; Ladd-Acosta C; Snieder H; Nystad W; Koppelman GH; Relton CL; Jaddoe VWV; Wilcox A; Melen E; London SJ
Journal article: ENVIRONMENTAL HEALTH: A GLOBAL ACCESS SCIENCE SOURCE. 2016;15:39
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM₁₀ exposure and diabetes
Eze IC; Imboden M; Kumar A; Adam M; von Eckardstein A; Stolz D; Gerbase MW; Kuenzli N; Turk A; Schindler C; Kronenberg F; Probst-Hensch N
Journal article: 2016
The genetic architecture of type 2 diabetes.
Kumar A; Fuchsberger C; Flannick J; Teslovich TM; Mahajan A; Agarwala V; Gaulton KJ; Ma C; Fontanillas P; Moutsianas L; McCarthy DJ; Rivas MA; Perry JR; Sim X; Blackwell TW; Robertson NR; Rayner NW; Cingolani P; Locke AE; Tajes JF; Highland HM
Journal article: AMERICAN JOURNAL OF HUMAN GENETICS. 2016;98:680-696
Bonnie R. Joubert, Janine F. Felix, 2, 3, 4, 58 Paul Yousefi, 5, 58 Kelly M. Bakulski, 6, 58 Allan C. Just, 7, 58 Carrie Breton, 8, 58 Sarah E. Reese, Christina A. Markunas, Rebecca C. Richmond, 10, 58
Xu C-J; Küpers LK; Oh SS; Hoyo C
Journal article: AGE. 2016;38:1-13
Common SIRT1 variants modify the effect of abdominal adipose tissue on aging-related lung function decline
Curjuric I; Imboden M; Bridevaux P-O; Gerbase MW; Haun M; Keidel D; Kumar A; Pons M; Rochat T; Schikowski T; others
Journal article: AMERICAN JOURNAL OF HUMAN GENETICS. 2016;98:680-696
DNA methylation in newborns and maternal smoking in pregnancy: genome-wide consortium meta-analysis
Joubert BR; Felix JF; Yousefi P; Bakulski KM; Just AC; Breton C; Reese SE; Markunas CA; Richmond RC; Xu C-J; others
Journal article: NATURE. 2016;536:41-47
The genetic architecture of type 2 diabetes
Fuchsberger C; Flannick J; Teslovich TM; Mahajan A; Agarwala V; Gaulton KJ; Ma C; Fontanillas P; Moutsianas L; McCarthy DJ; others
Journal article: NATURE. 2016;536
The genetic architecture of type 2 diabetes
McCarthy D; Mahajan A; Gaulton K; Moutsianas L; Rivas M; Perry J; Robertson N; Rayner N; Tajes J; Lindgren C; others
Journal article: ENVIRONMENTAL HEALTH: A GLOBAL ACCESS SCIENCE SOURCE. 2016;15:1-11
A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM 10 exposure and diabetes
Eze IC; Imboden M; Kumar A; Adam M; von Eckardstein A; Stolz D; Gerbase MW; Künzli N; Turk A; Schindler C; others
Article: NATURE COMMUNICATIONS. 2015;6:8658
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Artigas MS; Wain LV; Miller S; Kheirallah AK; Huffman JE; Ntalla I; Shrine N; Obeidat M; Trochet H; McArdle WL; Alves AC; Hui J; Zhao JH; Joshi PK; Teumer A; Albrecht E; Imboden M; Rawal R; Lopez LM; Marten J; Enroth S; Surakka I; Polasek O; Lyytikainen L-P; Granell R; Hysi PG; Flexeder C; Mahajan A; Beilby J; Bosse Y; Brandsma C-A; Campbell H; Gieger C; Glaeser S; Gonzalez JR; Grallert H; Hammond CJ; Harris SE; Hartikainen A-L; Heliovaara M; Henderson J; Hocking L; Horikoshi M; Hutri-Kahonen N; Ingelsson E; Johansson A; Kemp JP; Kolcic I; Kumar A; Lind L; Melen E; Musk AW; Navarro P; Nickle DC; Padmanabhan S; Raitakari OT; Ried JS; Ripatti S; Schulz H; Scott RA; Sin DD; Starr JM; Vinuela A; Voelzke H; Wild SH; Wright AF; Zemunik T; Jarvis DL; Spector TD; Evans DM; Lehtimaki T; Vitart V; Kahonen M; Gyllensten U; Rudan I; Deary IJ; Karrasch S; Probst-Hensch NM; Heinrich J; Stubbe B; Wilson JF; Wareham NJ; James AL; Morris AP; Jarvelin M-R; Hayward C; Sayers I; Strachan DP; Hall IP; Tobin MD; Deloukas P; Hansell AL; Hubbard R; Jackson VE; Marchini J; Pavord I; Thomson NC; Zeggini E
Journal article: NATURE COMMUNICATIONS. 2015;6
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Artigas MS; Wain LV; Miller S; Kheirallah AK; Huffman JE; Ntalla I; Shrine N; Obeidat M; Trochet H; McArdle WL; Alves AC; Hui J; Zhao JH; Joshi PK; Teumer A; Albrecht E; Imboden M; Rawal R; Lopez LM; Marten J; Enroth S; Surakka I; Polasek O; Lyytikäinen L-P; Granell R; Hysi PG; Flexeder C; Mahajan A; Beilby J; Bossé Y; Brandsma C-A; Campbell H; Gieger C; Gläser S; González JR; Grallert H; Hammond CJ; Harris SE; Hartikainen A-L; Heliövaara M; Henderson J; Hocking L; Horikoshi M; Hutri-Kähönen N; Ingelsson E; Johansson Å; Kemp JP; Kolcic I; Kumar A; Lind L; Melén E; Musk AW; Navarro P; Nickle DC; Padmanabhan S; Raitakari OT; Ried JS; Ripatti S; Schulz H; Scott RA; Sin DD; Starr JM; Deloukas P; Hansell AL; Hubbard R; Jackson VE; Marchini J; Pavord I; Thomson NC; Zeggini E; Viñuela A; Völzke H; Wild SH; Wright AF; Zemunik T; Jarvis DL; Spector TD; Evans DM; Lehtimäki T; Vitart V; Kähönen M; Gyllensten U; Rudan I; Deary IJ; Karrasch S; Probst-Hensch NM; Heinrich J; Stubbe B; Wilson JF; Wareham NJ; James AL; Morris AP; Jarvelin M-R; Hayward C; Sayers I; Strachan DP; Hall IP; Tobin MD
Article: NATURE GENETICS. 2015;47(12):1449-1456
Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
Paternoster L; Standl M; Waage J; Baurecht H; Hotze M; Strachan DP; Curtin JA; Bonnelykke K; Tian C; Takahashi A; Esparza-Gordillo J; Alves AC; Thyssen JP; den Dekker HT; Ferreira MA; Altmaier E; Sleiman PMA; Xiao FL; Gonzalez JR; Marenholz I; Kalb B; Pino-Yanes M; Xu C-J; Carstensen L; Groen-Blokhuis MM; Venturini C; Pennell CE; Barton SJ; Levin AM; Curjuric I; Bustamante M; Kreiner-Moller E; Lockett GA; Bacelis J; Bunyavanich S; Myers RA; Matanovic A; Kumar A; Tung JY; Hirota T; Kubo M; McArdle WL; Henderson AJ; Kemp JP; Zheng J; Smith GD; Rueschendorf F; Bauerfeind A; Lee-Kirsch MA; Arnold A; Homuth G; Schmidt CO; Mangold E; Cichon S; Keil T; Rodriguez E; Peters A; Franke A; Lieb W; Novak N; Foelster-Holst R; Horikoshi M; Pekkanen J; Sebert S; Husemoen LL; Grarup N; De Jongste JC; Rivadeneira F; Hofman A; Jaddoe VWV; Pasmans SGMA; Elbert NJ; Uitterlinden AG; Marks GB; Thompson PJ; Matheson MC; Robertson CF; Ried JS; Li J; Zuo XB; Zheng XD; Yin XY; Sun LD; McAleer MA; O'Regan GM; Fahy CMR; Campbell LE; Macek M; Kurek M; Hu D; Eng C; Postma DS; Feenstra B; Geller F; Hottenga JJ; Middeldorp CM; Hysi P; Bataille V; Spector T; Tiesler CMT; Thiering E; Pahukasahasram B; Yang JJ; Imboden M; Huntsman S; Vilor-Tejedor N; Relton CL; Myhre R; Nystad W; Custovic A; Weiss ST; Meyers DA; Soederhaell C; Melen E; Ober C; Raby BA; Simpson A; Jacobsson B; Holloway JW; Bisgaard H; Sunyer J; Probst-Hensch NM; Williams LK; Godfrey KM; Wang CA; Boomsma DI; Melbye M; Koppelman GH; Jarvis D; McLean WHI; Irvine AD; Zhang XJ; Hakonarson H; Gieger- C; Burchard EG; Martin NG; Duijts L; Linneberg A; Jarvelin M-R; Noethen MM; Lau S; Huebner N; Lee Y-A; Tamari M; Hinds DA; Glass D; Brown SJ; Heinrich J; Evans DM; Weidinger S
Journal article: PLOS GENETICS. 2015;11(4):e1005165
The Power of Gene-Based Rare Variant Methods to Detect Disease-Associated Variation and Test Hypotheses About Complex Disease
Moutsianas L; Agarwala V; Fuchsberger C; Flannick J; Rivas MA; Gaulton KJ; Albers PK; McVean G; Boehnke M; Altshuler D; McCarthy MI
Journal article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2015;123(1):72–79
Modification of the Association between PM 10 and Lung Function Decline by Cadherin 13 Polymorphisms in the SAPALDIA Cohort: A Genome-Wide Interaction Analysis
Imboden M; Kumar A; Curjuric I; Adam M; Thun GA; Haun M; Tsai M-Y; Pons M; Bettschart R; Turk A; Rochat T; Künzli N; Schindler C; Kronenberg F; Probst-Hensch NM
Journal article: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2015;191:1
B59 ASTHMA-LIKE PHENOTYPE: EMERGENCE OF (EPI) GENETICS AND TARGETED TRANSGENESIS:(epi) genetic Regulation Of Expression Of Il1rl1 Mrna And Il1rl1-A Protein Levels In Asthma
Dijk F; Grotenboer NS; Xu C; Kumar A; Soderhall C; Melen E; Lavi I; Dobano C; Guerra S; Savenije O; others
Journal article: PLOS GENETICS. 2015;11:e1004876
Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus
Mahajan A; Sim X; Ng HJ; Manning A; Rivas MA; Highland HM; Locke AE; Grarup N; Im HK; Cingolani P; others
Journal article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2015;123:72-79
Modification of the association between PM10 and lung function decline by cadherin 13 polymorphisms in the SAPALDIA cohort: a genome-wide interaction analysis
Imboden M; Kumar A; Curjuric I; Adam M; Thun GA; Haun M; Tsai M-Y; Pons M; Bettschart R; Turk A; others
Journal article: NATURE COMMUNICATIONS. 2015;6
Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation
Soler Artigas M; Wain LV; Miller S; Kheirallah AK; Huffman JE; Ntalla I; Shrine N; Obeidat M; Trochet H; McArdle WL; others
Journal article: PLOS GENETICS. 2015;11:e1005165
The power of gene-based rare variant methods to detect disease-associated variation and test hypotheses about complex disease
Moutsianas L; Agarwala V; Fuchsberger C; Flannick J; Rivas MA; Gaulton KJ; Albers PK; Consortium G; McVean G; Boehnke M; others
Journal article: TROPICAL MEDICINE AND INTERNATIONAL HEALTH. 2015;20:127-128
Modification of ambient air pollution and diabetes association by type 2 diabetes genetic risk score of 48 variants
Eze IC; Imboden M; Kumar A; von Eckardstein A; Stolz D; Gerbase MW; Künzli N; Rochat T; Kronenberg F; Schindler C; others
Journal article: PLOS ONE. 2014;9:e100776
Large-Scale Genome-Wide Association Studies and Meta-Analyses of Longitudinal Change in Adult Lung Function
Tang W; Kowgier M; Loth DW; Soler Artigas M; Joubert BR; Hodge E; Gharib SA; Smith AV; Ruczinski I; Gudnason V; Mathias RA; Harris TB; Hansel NN; Launer LJ; Barnes KC; Hansen JG; Albrecht E; Aldrich MC; Allerhand M; Barr RG; Brusselle GG; Couper DJ; Curjuric I; Davies G; Deary IJ; Dupuis J; Fall T; Foy M; Franceschini N; Gao W; Gläser S; Gu X; Hancock DB; Heinrich J; Hofman A; Imboden M; Ingelsson E; James A; Karrasch S; Koch B; Kritchevsky SB; Kumar A; Lahousse L; Li G; Lind L; Lindgren C; Liu Y; Lohman K; Lumley T; McArdle WL; Meibohm B; Morris AP; Morrison AC; Musk B; North KE; Palmer LJ; Probst-Hensch NM; Psaty BM; Rivadeneira F; Rotter JI; Schulz H; Smith LJ; Sood A; Starr JM; Strachan DP; Teumer A; Uitterlinden AG; Völzke H; Voorman A; Wain LV; Wells MT; Wilk JB; Williams OD; Heckbert SR; Stricker BH; London SJ; Fornage M; Tobin MD; O′Connor GT; Hall IP; Cassano PA
Journal article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(5):710–720
Simulation of Finnish Population History, Guided by Empirical Genetic Data, to Assess Power of Rare-Variant Tests in Finland
Wang SR; Agarwala V; Flannick J; Chiang CWK; Altshuler D; Hirschhorn JN; Flannick J; Manning A; Hartl C; Agarwala V; Fontanillas P; Green T; Banks E; DePristo M; Poplin R; Shakir K; Fennell T; Murphy J; Burtt N; Gabriel S; Altshuler D; Fuchsberger C; Kang HM; Sim X; Ma C; Locke A; Blackwell T; Jackson A; Teslovich T; Stringham H; Chines P; Kwan P; Huyghe J; Tan A; Jun G; Stitzel M; Bergman RN; Bonnycastle L; Tuomilehto J; Collins FS; Scott L; Mohlke K; Abecasis G; Boehnke M; Strom T; Gieger C; Müller-Nurasyid M; Grallert H; Kriebel J; Ried J; Hrabé de Angelis M; Huth C; Meisinger C; Peters A; Rathmann W; Strauch K; Meitinger T; Kravic J; Ladenvall C; Toumi T; Isomaa B; Groop L; Gaulton K; Moutsianas L; Rivas M; Pearson R; Mahajan A; Prokopenko I; Kumar A; Perry J; Chen J; Howie B; van de Bunt M; Small K; Lindgren C; Lunter G; Robertson N; Rayner W; Morris A; Buck D; Hattersley A; Spector T; McVean G; Frayling T; Donnelly P; McCarthy M
Journal article: PLOS GENETICS. 2014;10(4):e1004235
A Central Role for GRB10 in Regulation of Islet Function in Man
Prokopenko I; Poon W; Mägi R; Prasad B R; Salehi SA; Almgren P; Osmark P; Bouatia-Naji N; Wierup N; Fall T; Stančáková A; Barker A; Lagou V; Osmond C; Xie W; Lahti J; Jackson AU; Cheng Y-C; Liu J; O’Connell JR; Blomstedt PA; Fadista J; Alkayyali S; Dayeh T; Ahlqvist E; Taneera J; Lecoeur C; Kumar A; Hansson O; Hansson K; Voight BF; Kang HM; Levy-Marchal C; Vatin V; Palotie A; Syvänen A-C; Mari A; Weedon MN; Loos RJF; Ong KK; Nilsson P; Isomaa B; Tuomi T; Wareham NJ; Stumvoll M; Widen E; Lakka TA; Langenberg C; Tönjes A; Rauramaa R; Kuusisto J; Frayling TM; Froguel P; Walker M; Eriksson JG; Ling C; Kovacs P; Ingelsson E; McCarthy MI; Shuldiner AR; Silver KD; Laakso M; Groop L; Lyssenko V
Article: NATURE GENETICS. 2014;46(3):234-244
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Mahajan A; Go MJ; Zhang W; Below JE; Gaulton KJ; Ferreira T; Horikoshi M; Johnson AD; Ng MCY; Prokopenko I; Saleheen D; Wang X; Zeggini E; Abecasis GR; Adair LS; Almgren P; Atalay M; Aung T; Baldassarre D; Balkau B; Bao Y; Barnett AH; Barroso I; Basit A; Been LF; Beilby J; Bell GI; Benediktsson R; Bergman RN; Boehm BO; Boerwinkle E; Bonnycastle LL; Burtt N; Cai Q; Campbell H; Carey J; Cauchi S; Caulfield M; Chan JCN; Chang L-C; Chang T-J; Chang Y-C; Charpentier G; Chen C-H; Chen H; Chen Y-T; Chia K-S; Chidambaram M; Chines PS; Cho NH; Cho YM; Chuang L-M; Collins FS; Cornelis MC; Couper DJ; Crenshaw AT; van Dam RM; Danesh J; Das D; de Faire U; Dedoussis G; Deloukas P; Dimas AS; Dina C; Doney ASF; Donnelly PJ; Dorkhan M; van Duijn C; Dupuis J; Edkins S; Elliott P; Emilsson V; Erbel R; Eriksson JG; Escobedo J; Esko T; Eury E; Florez JC; Fontanillas P; Forouhi NG; Forsen T; Fox C; Fraser RM; Frayling TM; Froguel P; Frossard P; Gao Y; Gertow K; Gieger C; Gigante B; Grallert H; Grant GB; Groop LC; Groves CJ; Grundberg E; Guiducci C; Hamsten A; Han B-G; Hara K; Hassanali N; Hattersley AT; Hayward C; Hedman AK; Herder C; Hofman A; Holmen OL; Hovingh K; Hreidarsson AB; Hu C; Hu FB; Hui J; Humphries SE; Hunt SE; Hunter DJ; Hveem K; Hydrie ZI; Ikegami H; Illig T; Ingelsson E; Islam M; Isomaa B; Jackson AU; Jafar T; James A; Jia W; Joeckel K-H; Jonsson A; Jowett JBM; Kadowaki T; Kang HM; Kanoni S; Kao WHL; Kathiresan S; Kato N; Katulanda P; Keinanen-Kiukaanniemi SM; Kelly AM; Khan H; Khaw K-T; Khor C-C; Kim H-L; Kim S; Kim YJ; Kinnunen L; Klopp N; Kong A; Korpi-Hyovalti E; Kowlessur S; Kraft P; Kravic J; Kristensen MM; Krithika S; Kumar A; Kumate J; Kuusisto J; Kwak SH; Laakso M; Lagou V; Lakka TA; Langenberg C; Langford C; Lawrence R; Leander K; Lee J-M; Lee NR; Li M; Li X; Li Y; Liang J; Liju S; Lim W-Y; Lind L; Lindgren CM; Lindholm E; Liu C-T; Liu JJ; Lobbens S; Long J; Loos RJF; Lu W; Luan J; Lyssenko V; Ma RCW; Maeda S; Maegi R; Mannisto S; Matthews DR; Meigs JB; Melander O; Metspalu A; Meyer J; Mirza G; Mihailov E; Moebus S; Mohan V; Mohlke KL; Morris AD; Muehleisen TW; Mueller-Nurasyid M; Musk B; Nakamura J; Nakashima E; Navarro P; Peng-Keat N; Nica AC; Nilsson PM; Njolstad I; Noethen MM; Ohnaka K; Ong TH; Owen KR; Palmer CNA; Pankow JS; Park KS; Parkin M; Pechlivanis S; Pedersen NL; Peltonen L; Perry JRB; Peters A; Pinidiyapathirage JM; Platou CGP; Potter S; Price JF; Qi L; Radha V; Rallidis L; Rasheed A; Rathmann W; Rauramaa R; Raychaudhuri S; Rayner NW; Rees SD; Rehnberg E; Ripatti S; Robertson N; Roden M; Rossin EJ; Rudan I; Rybin D; Saaristo TE; Salomaa V; Saltevo J; Samuel M; Sanghera DK; Saramies J; Scott J; Scott LJ; Scott RA; Segre AV; Sehmi J; Sennblad B; Shah N; Shah S; Shera AS; Shu XO; Shuldiner AR; Sigurdsson G; Sijbrands E; Silveira A; Sim X; Sivapalaratnam S; Small KS; So WY; Stancakova A; Stefansson K; Steinbach G; Steinthorsdottir V; Stirrups K; Strawbridge RJ; Stringham HM; Sun Q; Suo C; Syvanen A-C; Takayanagi R; Takeuchi F; Tay WT; Teslovich TM; Thorand B; Thorleifsson G; Thorsteinsdottir U; Tikkanen E; Trakalo J; Tremoli E; Trip MD; Tsai FJ; Tuomi T; Tuomilehto J; Uitterlinden AG; Valladares-Salgado A; Vedantam S; Veglia F; Voight BF; Wang C; Wareham NJ; Wennauer R; Wickremasinghe AR; Wilsgaard T; Wilson JF; Wiltshire S; Winckler W; Wong TY; Wood AR; Wu J-Y; Wu Y; Yamamoto K; Yamauchi T; Yang M; Yengo L; Yokota M; Young R; Zabaneh D; Zhang F; Zhang R; Zheng W; Zimmet PZ; Altshuler D; Bowden DW; Cho YS; Cox NJ; Cruz M; Hanis CL; Kooner J; Lee J-Y; Seielstad M; Teo YY; Boehnke M; Parra EJ; Chambers JC; Tai ES; McCarthy MI; Morris AP
Journal article: PLOS GENETICS. 2014;10:e1004235
A Central Role for GRB10 in Regulation of Islet Function in Man
Prokopenko I; Poon W; Mägi R; Prasad R; Salehi SA; Almgren P; Osmark P; Bouatia-Naji N; Wierup N; Fall T; others
Journal article: NATURE GENETICS. 2014;46:234-244
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Consortium DGRAM-AD; Consortium AGENT2D; Consortium SAT2DS; Consortium MAT2DM; Consortium T2DGEBN; Mahajan A; Go MJ; Zhang W; Below JE; Gaulton KJ; others
Journal article: PLOS ONE. 2014;9(7):e100776
Large-scale genome-wide association studies and meta-analyses of longitudinal change in adult lung function
Tang W; Kowgier M; Loth DW; Soler Artigas M; Joubert BR; Hodge E; Gharib SA; Smith AV; Ruczinski I; Gudnason V; others
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;133:885-888
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure
Scholtens S; Postma DS; Moffatt MF; Panasevich S; Granell R; Henderson AJ; Melén E; Nyberg F; Pershagen G; Jarvis D; others
Journal article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. 2014;111:13127-13132
Rare variants in PPARG with decreased activity in adipocyte differentiation are associated with increased risk of type 2 diabetes
Majithia AR; Flannick J; Shahinian P; Guo M; Bray M-A; Fontanillas P; Gabriel SB; Consortium G; Project NHGRIJH; Consortium SIGMAT; others
Journal article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94:710-720
Simulation of Finnish population history, guided by empirical genetic data, to assess power of rare-variant tests in Finland
Wang SR; Agarwala V; Flannick J; Chiang CWK; Altshuler D; Manning A; Hartl C; Fontanillas P; Green T; Banks E; others
Journal article: NATURE GENETICS. 2013;45(12):1418–1427
Evaluating empirical bounds on complex disease genetic architecture
Agarwala V; Flannick J; Sunyaev S; Altshuler D
Article: CLINICAL AND EXPERIMENTAL ALLERGY. 2013;43(4):463-474
Genome-wide association study of body mass index in 23000 individuals with and without asthma
Melen E; Granell R; Kogevinas M; Strachan D; Gonzalez JR; Wjst M; Jarvis D; Ege M; Braun-Fahrlaender C; Genuneit J; Horak E; Bouzigon E; Demenais F; Kauffmann F; Siroux V; Michel S; von Berg A; Heinzmann A; Kabesch M; Probst-Hensch NM; Curjuric I; Imboden M; Rochat T; Henderson J; Sterne JAC; McArdle WL; Hui J; James AL; Musk AW; Palmer LJ; Becker A; Kozyrskyj AL; Chan-Young M; Park JE; Leung A; Daley D; Freidin MB; Deev IA; Ogorodova LM; Puzyrev VP; Celedon JC; Brehm JM; Cloutier MM; Canino G; Acosta-Perez E; Soto-Quiros M; Avila L; Bergstrom A; Magnusson J; Soderhall C; Kull I; Scholtens S; Boezen HM; Koppelman GH; Wijga AH; Marenholz I; Esparza-Gordillo J; Lau S; Lee Y-A; Standl M; Tiesler CMT; Flexeder C; Heinrich J; Myers RA; Ober C; Nicolae DL; Farrall M; Kumar A; Moffatt MF; Cookson WOCM; Lasky-Su J
Journal article: PLOS GENETICS. 2013;9(8):e1003585
Causal and Synthetic Associations of Variants in the SERPINA Gene Cluster with Alpha1-antitrypsin Serum Levels
Thun GA; Imboden M; Ferrarotti I; Kumar A; Obeidat M; Zorzetto M; Haun M; Curjuric I; Couto Alves A; Jackson VE; Albrecht E; Ried JS; Teumer A; Lopez LM; Huffman JE; Enroth S; Bossé Y; Hao K; Timens W; Gyllensten U; Polasek O; Wilson JF; Rudan I; Hayward C; Sandford AJ; Deary IJ; Koch B; Reischl E; Schulz H; Hui J; James AL; Rochat T; Russi EW; Jarvelin M-R; Strachan DP; Hall IP; Tobin MD; Dahl M; Fallgaard Nielsen S; Nordestgaard BG; Kronenberg F; Luisetti M; Probst-Hensch NM
Journal article: PLOS GENETICS. 2013;9:e1003585
Causal and synthetic associations of variants in the serpina gene cluster with alpha1-antitrypsin serum levels
Thun GA; Imboden M; Ferrarotti I; Kumar A; Obeidat M; Zorzetto M; Haun M; Curjuric I; Alves AC; Jackson VE; others
Journal article: NATURE GENETICS. 2013;45:1418
Evaluating empirical bounds on complex disease genetic architecture
Agarwala V; Flannick J; Sunyaev S; Altshuler D; Consortium G; others
Journal article: CLINICAL AND EXPERIMENTAL ALLERGY. 2013;43:463-474
Genome-wide association study of body mass index in 23 000 individuals with and without asthma
Melén E; Granell R; Kogevinas M; Strachan D; Gonzalez JR; Wjst M; Jarvis D; Ege M; Braun-Fahrländer C; Genuneit J; others
Article: NATURE GENETICS. 2012;44(9):981-990
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Morris AP; Voight BF; Teslovich TM; Ferreira T; Segre AV; Steinthorsdottir V; Strawbridge RJ; Khan H; Grallert H; Mahajan A; Prokopenko I; Kang HM; Dina C; Esko T; Fraser RM; Kanoni S; Kumar A; Lagou V; Langenberg C; Luan J; Lindgren CM; Mueller-Nurasyid M; Pechlivanis S; Rayner NW; Scott LJ; Wiltshire S; Yengo L; Kinnunen L; Rossin EJ; Raychaudhuri S; Johnson AD; Dimas AS; Loos RJF; Vedantam S; Chen H; Florez JC; Fox C; Liu C-T; Rybin D; Couper DJ; Kao WHL; Li M; Cornelis MC; Kraft P; Sun Q; van Dam RM; Stringham HM; Chines PS; Fischer K; Fontanillas P; Holmen OL; Hunt SE; Jackson AU; Kong A; Lawrence R; Meyer J; Perry JRB; Platou CGP; Potter S; Rehnberg E; Robertson N; Sivapalaratnam S; Stancakova A; Stirrups K; Thorleifsson G; Tikkanen E; Wood AR; Almgren P; Atalay M; Benediktsson R; Bonnycastle LL; Burtt N; Carey J; Charpentier G; Crenshaw AT; Doney ASF; Dorkhan M; Edkins S; Emilsson V; Eury E; Forsen T; Gertow K; Gigante B; Grant GB; Groves CJ; Guiducci C; Herder C; Hreidarsson AB; Hui J; James A; Jonsson A; Rathmann W; Klopp N; Kravic J; Krjutskov K; Langford C; Leander K; Lindholm E; Lobbens S; Mannisto S; Mirza G; Muehleisen TW; Musk B; Parkin M; Rallidis L; Saramies J; Sennblad B; Shah S; Sigurdsson G; Silveira A; Steinbach G; Thorand B; Trakalo J; Veglia F; Wennauer R; Winckler W; Zabaneh D; Campbell H; van Duijn C; Uitterlinden AG; Hofman A; Sijbrands E; Abecasis GR; Owen KR; Zeggini E; Trip MD; Forouhi NG; Syvanen A-C; Eriksson JG; Peltonen L; Noethen MM; Balkau B; Palmer CNA; Lyssenko V; Tuomi T; Isomaa B; Hunter DJ; Qi L; Shuldiner AR; Roden M; Barroso I; Wilsgaard T; Beilby J; Hovingh K; Price JF; Wilson JF; Rauramaa R; Lakka TA; Lind L; Dedoussis G; Njolstad I; Pedersen NL; Khaw K-T; Wareham NJ; Keinanen-Kiukaanniemi SM; Saaristo TE; Korpi-Hyovalti E; Saltevo J; Laakso M; Kuusisto J; Metspalu A; Collins FS; Mohlke KL; Bergman RN; Tuomilehto J; Boehm BO; Gieger C; Hveem K; Cauchi S; Froguel P; Baldassarre D; Tremoli E; Humphries SE; Saleheen D; Danesh J; Ingelsson E; Ripatti S; Salomaa V; Erbel R; Joeckel K-H; Moebus S; Peters A; Illig T; de Faire U; Hamsten A; Morris AD; Donnelly PJ; Frayling TM; Hattersley AT; Boerwinkle E; Melander O; Kathiresan S; Nilsson PM; Deloukas P; Thorsteinsdottir U; Groop LC; Stefansson K; Hu F; Pankow JS; Dupuis J; Meigs JB; Altshuler D; Boehnke M; McCarthy MI
Journal article: PLOS ONE. 2012;7:e40175
Different Genes Interact with Particulate Matter and Tobacco Smoke Exposure in Affecting Lung Function Decline in the General Population
Curjuric I; Imboden M; Nadif R; Kumar A; Schindler C; Haun M; Kronenberg F; Künzli N; Phuleria H; Postma DS; Russi EW; Rochat T; Demenais F; Probst-Hensch NM
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129(5):1218–1228
Genome-wide association study of lung function decline in adults with and without asthma
Imboden M; Bouzigon E; Curjuric I; Ramasamy A; Kumar A; Hancock DB; Wilk JB; Vonk JM; Thun GA; Siroux V; Nadif R; Monier F; Gonzalez JR; Wjst M; Heinrich J; Loehr LR; Franceschini N; North KE; Altmüller J; Koppelman GH; Guerra S; Kronenberg F; Lathrop M; Moffatt MF; O’Connor GT; Strachan DP; Postma DS; London SJ; Schindler C; Kogevinas M; Kauffmann F; Jarvis DL; Demenais F; Probst-Hensch NM
Journal article: 2012
Different Genes Interact with Particulate Matter and Tobacco Smoke Exposure in
Curjuric I; Imboden M; Nadif R; Kumar A; Schindler C; others
Journal article: PLOS ONE. 2012;7(7):e40175
Different genes interact with particulate matter and tobacco smoke exposure in affecting lung function decline in the general population
Curjuric I; Imboden M; Nadif R; Kumar A; Schindler C; Haun M; Kronenberg F; Künzli N; Phuleria H; Postma DS; others
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2012;129:1218-1228
Genome-wide association study of lung function decline in adults with and without asthma
Imboden M; Bouzigon E; Curjuric I; Ramasamy A; Kumar A; Hancock DB; Wilk JB; Vonk JM; Thun GA; Siroux V; others
Journal article: NATURE GENETICS. 2012;44:981
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Morris AP; Voight BF; Teslovich TM; Ferreira T; Segré AV; Steinthorsdottir V; Strawbridge RJ; Khan H; Grallert H; Mahajan A; others
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Assessing the impact of missing genotype data in rare variant association analysis
Mägi R; Kumar A; Morris AP
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;128(5):996–1005
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order
Ramasamy A; Curjuric I; Coin LJ; Kumar A; McArdle WL; Imboden M; Leynaert B; Kogevinas M; Schmid-Grendelmeier P; Pekkanen J; Wjst M; Bircher AJ; Sovio U; Rochat T; Hartikainen A-L; Balding DJ; Jarvelin M-R; Probst-Hensch N; Strachan DP; Jarvis DL
Journal article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2011;128:996-1005
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order
Ramasamy A; Curjuric I; Coin LJ; Kumar A; McArdle WL; Imboden M; Leynaert B; Kogevinas M; Schmid-Grendelmeier P; Pekkanen J; others
Journal article: PLOS ONE. 2010;5(11):e13894
Unifying Candidate Gene and GWAS Approaches in Asthma
Michel S; Liang L; Depner M; Klopp N; Ruether A; Kumar A; Schedel M; Vogelberg C; von Mutius E; von Berg A; Bufe A; Rietschel E; Heinzmann A; Laub O; Simma B; Frischer T; Genuneit J; Gut IG; Schreiber S; Lathrop M; Illig T; Kabesch M
Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2010;21(10):1791–1797
HLA Has Strongest Association with IgA Nephropathy in Genome-Wide Analysis
Feehally J; Farrall M; Boland A; Gale DP; Gut I; Heath S; Kumar A; Peden JF; Maxwell PH; Morris DL; Padmanabhan S; Vyse TJ; Zawadzka A; Rees AJ; Lathrop M; Ratcliffe PJ
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2010;363(13):1211-1221
A Large-Scale, Consortium-Based Genomewide Association Study of Asthma
Moffatt MF; Gut IG; Demenais F; Strachan DP; Bouzigon E; Heath S; von Mutius E; Farrall M; Lathrop M; Cookson WOCM; Kumar A; Burney P; Jarvis D; Wjst M; Kogevinas M; Jogi R; Janson C; Franklin KA; Omenaas E; Leynaert B; Pin I; Heinrich J; Probst-Hensch NM; Anto JM; Sunyer J; Maldonado J-A; Martinez-Moratalla J; Urrutia I; Payo F; Kauffmann F; Dizier M-H; Siroux V; Boznanski A; Braun-Fahrlaender C; Genuneit J; Glas J; Horak E; Kabesch M; Pillai SG; Helms PJ; Carlsen K; Carlsen K-H; Gerritsen J; Silverman M; Sly P; Tsanakas J; Von Berg A; Whyte M; Blumenthal M; Imboden M; Rochat T; Thun GA; Gerbase MW; Curjuric I; Gaspoz J-M; Liu L-JS; Wouters IM; Sigsgaard T; Heederik D; Basinas I; Schlunssen V; Omland O; Cullinan P; Vermeulen R; Henderson J; Granell R; McArdle WL; Smith GD; James AL; Hui J; Palmer LJ; Beilby J; Musk AW; Laprise C; Hudson TJ; Lemire M; Daley D; Becker A; Chan-Yeung M; Sandford A; Kozyrskyj AL; Pare P; Ferguson A; Dimich-Ward H; Watson WT; Freidin MB; Bragina EI; Deev IA; Deeva EV; Kobyakova OS; Puzyrev VP; Ogorodova LM; Khusnutdinova EK; Karunas AS; Fedorova YY; Hall IP; Sayers I; Tobin MD; Wan YI; Heaney LG; Al-Momani BAH; Mansur AH; Manney S; Thomson NC; Chaudhuri R; Brightling CE; Bafadhel M; Singapuri A; Niven R; Simpson A; Holloway JW; Howarth PH; Polonikov AV; Ivanov VP; Solodilova MA; Melen E; Pershagen G; Bergstroem A; Kull I; Nyberg F; Wickman M; Soderhall C; Kere J; Postma DS; Kerkhof M; Brunekreef B; Smit HA; de Jongste JC; Wijga A; Aalberse RC; Hoekstra MO; Koppelman GH; Binia A; Chung KF; Bhavsar P; Chow F; Macedo P; Menzies-Gow A; van Stiphout N; Bush A; Lee Y-A; Esparza-Gordillo J; Nickel R; Wahn U; Lau S; Marenholz I; Haahtela T; von Hertzen L; Jousilahti P; Laatikainen T; Makela MJ; Vartiainen E; Laitinen T; Balding DJ; Peden JF; Corda E; Lechner D; Besse C; Zelenika D; Boland A; Bacq D; Demonchy S; Blanche H; Kamatani Y; von Mutius E; Farrall M; Lathrop M; Cookson WOCM
Journal article: NEW ENGLAND JOURNAL OF MEDICINE. 2010;363:1211-1221
A large-scale, consortium-based genomewide association study of asthma
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Genome-Wide Analysis Identifies Strong Association Between HLA and IgA Nephropathy
Feehally J; Farrall M; Boland A; Gale DP; Gut I; Heath S; Kumar A; Peden JF; Maxwell PH; Morris DL
Journal article: JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY. 2010;21:1791-1797
HLA has strongest association with IgA nephropathy in genome-wide analysis
Feehally J; Farrall M; Boland A; Gale DP; Gut I; Heath S; Kumar A; Peden JF; Maxwell PH; Morris DL; others
Journal article: DIABETOLOGIA. 2010;53:S28
Identification of additional type 2 diabetes susceptibility loci through large-scale replication using" Metabochip": early result
Prokopenko I; Mahajan A; Lagou V; Robertson N; Rayner W; Kumar A; Groves CJ; Buck D; Doney A; Palmer CNA; others
Journal article: PLOS ONE. 2010;5:e13894
Unifying candidate gene and GWAS approaches in asthma
Michel S; Liang L; Depner M; Klopp N; Ruether A; Kumar A; Schedel M; Vogelberg C; von Mutius E; von Berg A; others
Journal article: BIOINFORMATICS. 2007;23(12):1545–1549
Management, presentation and interpretation of genome scans using GSCANDB
Taylor M; Valdar W; Kumar A; Flint J; Mott R
Journal article: BIOINFORMATICS. 2007;23:1545-1549
Management, presentation and interpretation of genome scans using GSCANDB
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Journal article:
A Central Role for GRB10 in Regulation of Islet Function
Prokopenko I; Poon W; Prasad R; Salehi SA; Almgren P; Osmark P; Bouatia-naji N; Wierup N; Fall T; Barker A; others
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Online Repository Genome wide association study of lung function decline in adults with and without asthma.
Imboden M; Bouzigon E; Curjuric I; Ramasamy A; Kumar A; Hancock DB; Wilk JB; Vonk JM; Thun GA; Siroux V; others
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Jackson VE; Latourelle JC; Wain LV; Smith AV; Grove ML; Bartz TM; Obeidat M; Province MA; Gao W; Qaiser B; others
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loci for lung function [version 1; referees: 1 approved
Jackson VE; Latourelle JC; Wain LV; Smith AV; Grove ML; Bartz TM; Obeidat M; Province MA; Gao W; Qaiser B; others
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Genome-wide exploration of inflammation-related proteins and Type 2 asthma
Hernandez-Pacheco N; Bjorkander S; Klevebro S; Merid SK; Kumar A; Mogensen I; Janson C; Palmberg L; Van Hage M; Georgellis A; Bergstrom A; Kull I; Melen E
Conference publication: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;76:406-407
Developmental clusters of allergic diseases: Early-life risk factors, characteristics and genetic effects
Kilanowski A; Thiering E; Kress S; Wang G; Kumar A; Schikowski T; Berdel D; Von Berg A; Bauer C; Koletzko S; Heinrich J; Herberth G; Melen E; Peters A; Standl M
Preprint: MEDRXIV. 2020
Genomic and phenomic insights from an atlas of genetic effects on DNA methylation
Min JL; Hemani G; Hannon E; Dekkers KF; Castillo-Fernandez J; Luijk R; Carnero-Montoro E; Lawson DJ; Burrows K; Suderman M; Bretherick AD; Richardson TG; Klughammer J; Iotchkova V; Sharp G; Al Khleifat A; Shatunov A; Iacoangeli A; McArdle WL; Ho KM; Kumar A; Söderhäll C; Soriano-Tárraga C; Giralt-Steinhauer E; Kazmi N; Mason D; McRae AF; Corcoran DL; Sugden K; Kasela S; Cardona A; Day FR; Cugliari G; Viberti C; Guarrera S; Lerro M; Gupta R; Bollepalli S; Mandaviya P; Zeng Y; Clarke T-K; Walker RM; Schmoll V; Czamara D; Ruiz-Arenas C; Rezwan FI; Marioni RE; Lin T; Awaloff Y; Germain M; Aïssi D; Zwamborn R; van Eijk K; Dekker A; van Dongen J; Hottenga J-J; Willemsen G; Xu C-J; Barturen G; Català-Moll F; Kerick M; Wang C; Melton P; Elliott HR; Shin J; Bernard M; Yet I; Smart M; Gorrie-Stone T; Consortium B; Shaw C; Al Chalabi A; Ring SM; Pershagen G; Melén E; Jiménez-Conde J; Roquer J; Lawlor DA; Wright J; Martin NG; Montgomery GW; Moffitt TE; Poulton R; Esko T; Milani L; Metspalu A; Perry JRB; Ong KK; Wareham NJ; Matullo G; Sacerdote C; Caspi A; Arseneault L; Gagnon F; Ollikainen M; Kaprio J; Felix JF; Rivadeneira F; Tiemeier H; van IJzendoorn MH; Uitterlinden AG; Jaddoe VW; Haley C; McIntosh AM; Evans KL; Murray A; Räikkönen K; Lahti J; Nohr EA; Sørensen TI; Hansen T; Morgen CS; Binder EB; Lucae S; Gonzalez JR; Bustamante M; Sunyer J; Holloway JW; Karmaus W; Zhang H; Deary IJ; Wray NR; Starr JM; Beekman M; van Heemst D; Slagboom PE; Morange P-E; Trégouët D-A; Veldink JH; Davies GE; de Geus EJ; Boomsma DI; Vonk JM; Brunekreef B; Koppelman GH; Alarcón-Riquelme ME; Huang R-C; Pennell C; van Meurs J; Ikram MA; Hughes AD; Tillin T; Chaturvedi N; Pausova Z; Paus T; Spector TD; Kumari M; Schalkwyk LC; Visscher PM; Smith GD; Bock C; Gaunt TR; Bell JT; Heijmans BT; Mill J; Relton CL
Corrigendum: NATURE GENETICS. 2018;50(9):1343
Author Correction: Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Waage J; Standl M; Curtin JA; Jessen LE; Thorsen J; Tian C; Schoettler N; 23andMe Research Team; AAGC collaborators; Flores C; Abdellaoui A; Ahluwalia TS; Alves AC; Amaral AFS; Antó JM; Arnold A; Barreto-Luis A; Baurecht H; van Beijsterveldt CEM; Bleecker ER; Bonàs-Guarch S; Boomsma DI; Brix S; Bunyavanich S; Burchard EG; Chen Z; Curjuric I; Custovic A; den Dekker HT; Dharmage SC; Dmitrieva J; Duijts L; Ege MJ; Gauderman WJ; Georges M; Gieger C; Gilliland F; Granell R; Gui H; Hansen T; Heinrich J; Henderson J; Hernandez-Pacheco N; Holt P; Imboden M; Jaddoe VWV; Jarvelin M-R; Jarvis DL; Jensen KK; Jónsdóttir I; Kabesch M; Kaprio J; Kumar A; Lee Y-A; Levin AM; Li X; Lorenzo-Diaz F; Melén E; Mercader JM; Meyers DA; Myers R; Nicolae DL; Nohr EA; Palviainen T; Paternoster L; Pennell CE; Pershagen G; Pino-Yanes M; Probst-Hensch NM; Rüschendorf F; Simpson A; Stefansson K; Sunyer J; Sveinbjornsson G; Thiering E; Thompson PJ; Torrent M; Torrents D; Tung JY; Wang CA; Weidinger S; Weiss S; Willemsen G; Williams LK; Ober C; Hinds DA; Ferreira MA; Bisgaard H; Strachan DP; Bønnelykke K
Preprint: BIORXIV. 2017
Meta-analysis of exome array data identifies six novel genetic loci for lung function
Jackson VE; Latourelle JC; Wain LV; Smith AV; Grove ML; Bartz TM; Obeidat M; Province MA; Gao W; Qaiser B; Porteous DJ; Cassano PA; Ahluwalia TS; Grarup N; Li J; Altmaier E; Marten J; Harris SE; Manichaikul A; Pottinger TD; Li-Gao R; Lind-Thomsen A; Mahajan A; Lahousse L; Imboden M; Teumer A; Prins B; Lyytikäinen L-P; Eiriksdottir G; Franceschini N; Sitlani CM; Brody JA; Bossé Y; Timens W; Kraja A; Loukola A; Tang W; Liu Y; Bork-Jensen J; Justesen JM; Linneberg A; Lange LA; Rawal R; Karrasch S; Huffman JE; Smith BH; Davies G; Burkart KM; Mychaleckyj JC; Bonten TN; Enroth S; Lind L; Brusselle GG; Kumar A; Stubbe B; Group USS; Kähönen M; Wyss AB; Psaty BM; Heckbert SR; Hao K; Rantanen T; Kritchevsky SB; Lohman K; Skaaby T; Pisinger C; Hansen T; Schulz H; Polasek O; Campbell A; Starr JM; Rich SS; Mook-Kanamori DO; Johansson Å; Ingelsson E; Uitterlinden AG; Weiss S; Raitakari OT; Gudnason V; North KE; Gharib SA; Sin DD; Taylor KD; O’Connor GT; Kaprio J; Harris TB; Pedersen O; Vestergaard H; Wilson JG; Strauch K; Hayward C; Kerr S; Deary IJ; Barr RG; de Mutsert R; Gyllensten U; Morris AP; Ikram MA; Probst-Hensch NM; Gläser S; Zeggini E; Lehtimäki T; Strachan DP; Dupuis J; Morrison AC; Hall IP; Tobin MD; London SJ
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2016;48:pa1209
meQTL analysis of asthma GWAS loci and DNA methylation
Kumar A; Soderhall C; Merid S; Xu C; Gruzieva O; Koppelman G; Kere J; Pershagen G; Melen E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2016;48:oa5004
Differentially methylated genes related to gestational age are also expressed during fetal lung development
Merid SK; Xu C-J; Bustamante M; Baiz N; Annesi-Maesano I; Anto JM; Bousquet J; Gruzieva O; Kere J; Kumar A; Pershagen G; Postma D; Sunyer J; Soderhall C; Tantisira K; Weiss ST; Koppelman GH; Melen E
Conference publication: EUROPEAN RESPIRATORY JOURNAL. 2015;46:oa1455
An integrative genomics approach identifies new asthma pathways related to air pollution exposure
Gref A; Merid SK; Gruzieva O; Ballereau S; Becker A; Bellander T; Bergstrom A; Bosse Y; Bottai M; Chan-Yeung M; Fuertes E; Ierodakoniou D; Jiang R; Kobor MS; Korek M; Kozyrskyj AL; Kumar A; Lemonnier N; MacIntyre E; Nickle D; Obeidat M; Pellet J; Standl M; Saaf A; Soderhall C; Tiesler CMT; Van den Berge M; Vonk JM; Vora H; Xu C-J; Anto JM; Auffray C; Brauer M; Bousquet J; Brunekreef B; Gauderman WJ; Heinrich J; Kere J; Koppelman G; Postma D; Carlsten C; Pershagen G; Melen E
Conference publication: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2015;191
(epi)genetic Regulation Of Expression Of Il1rl1 Mrna And Il1rl1-A Protein Levels In Asthma
Dijk F; Grotenboer NS; Xu C; Kumar A; Soderhall C; Melen E; Lavi I; Dobano C; Guerra S; Savenije O; Nolte I; Van der Vlies P; Smit H; Brunekreef B; Van der Valk R; De Jongste J; Kerkhof M; Nawijn MC; Postma DS; Koppelman GH
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;133(3):885-888
Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure
Scholtens S; Postma DS; Moffatt MF; Panasevich S; Granell R; Henderson AJ; Melen E; Nyberg F; Pershagen G; Jarvis D; Ramasamy A; Wjst M; Svanes C; Bouzigon E; Demenais F; Kauffmann F; Siroux V; von Mutius E; Ege MJ; Braun-Fahrlaender C; Genuneit J; Brunekreef B; Smit HA; Wijga AH; Kerkhof M; Curjuric I; Imboden M; Thun GA; Probst-Hensch N; Freidin MB; Bragina EI; Deev IA; Puzyrev VP; Daley D; Park J; Becker A; Chan-Yeung M; Kozyrskyj AL; Pare P; Marenholz I; Lau S; Keil T; Lee Y-A; Kabesch M; Wijmenga C; Franke L; Nolte IM; Vonk J; Kumar A; Farrall M; Cookson WOCM; Strachan DP; Koppelman GH; Boezen HM
Conference publication: DIABETES. 2014;63:A413
Identification of Gene Loss of Function Deletions from Dense Exome Array Data and Their Role in Type 2 Diabetes
Thurner M; Mahajan A; Robertson N; Kumar A; Rayner W; Moutsianas L; Fernandez J; Karpe F; Palmer CN; Spector TD; others
Conference publication: DIABETES. 2014;63:A37
Whole-Exome Sequencing in Type 1 Diabetic Nephropathy
Rayner NW; Van Zuydam N; Juliusdottir T; Fadista J; Kumar A; Sandholm N; Ahlqvist E; Gutteridge A; Fauman EB; Brosnan MJ; others
Conference publication: ISEE CONFERENCE ABSTRACTS 25. 2013;2013:4247
Genome-wide interaction study identifies Cadherin 13 as effect modifier of cumulative PM10 exposure on lung function decline.
Imboden M; Schindler C; Kumar A; Curjuric I; Phuleria HC; Tsai M-Y; Kuenzli N; Rochat T; Kronenberg F; Probst-Hensch N
Conference publication: GENETIC EPIDEMIOLOGY. 2012;36:143
Interaction of oxidative stress pathway genes with particulate matter and tobacco smoke on the course of airflow obstruction during 11 years
Curjuric I; Imboden M; Nadif R; Kumar A; Liu SLJ; Phuleria H; Rochat T; Schindler C; Demenais F; Probst-Hensch NM
Conference publication: BMC PROCEEDINGS. 2011;5:1-6
Assessing the impact of missing genotype data in rare variant association analysis
Mägi R; Kumar A; Morris AP
Conference publication: ISEE CONFERENCE ABSTRACTS 23. 2011;2011
GENOME-WIDE INTERACTION STUDY OF CUMULATIVE PARTICULATE MATTER EXPOSURE ON AGE-RELATED LUNG FUNCTION DECLINE IN ADULTS, THE SAPALDIA COHORT.
Imboden M; Curjuric I; Liu SLJ; Kumar A; Rochat T; Künzli N; Probst-Hensch NM
Book chapter: D101. ASTHMA GENETICS. 2011;p. A6184
Genome Wide Association Study Identifies Locus Determining Genetic Heterogeneity Of Lung Function Decline In Asthmatic And Non-Asthmatic Adults
Imboden M; Bouzigon E; Curjuric I; Ramasamy A; Kumar A; Hancock DB; Wilk JB; Vonk J; Strachan DP; Postma DS; others
Book chapter: A51. GENETIC STUDIES OF LUNG DISEASE. 2011;p. A1755
Genomewide Association With Alpha1-Antitrypsin Blood Levels In A Subset Of The SAPALDIA Cohort Study
Imboden M; Thun GA; Kumar A; Curjuric I; Ferrarotti I; Rochat T; Russi EW; Luisetti M; Probst-Hensch NM
Conference publication: ISEE CONFERENCE ABSTRACTS 23. 2011;2011
Oxidative stress pathway genes, particulate matter, and lung function decline
Curjuric I; Imboden M; Nadif R; Kumar A; Bouzigon E; Liu LJS; Phuleria H; Rochat T; Schindler C; Demenais F; others
Conference publication: GENETIC EPIDEMIOLOGY. 2010;34:972
Genomewide Association with Alpha1-Antitrypsin Blood Levels in a Subset of the SAPALDIA Cohort Study
Thun GA; Kumar A; Imboden M; Curjuric I; Rochat T; Russi EW; Luisetti M; Probst-Hensch NM
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