Anna Lindstrand
Om mig
Jag arbetar som kliniskt aktiv forskare på KI/KS och leder en forskargrupp som arbetar med translationell forskning i frontlinjen med fokus på underliggande cellulära mekanismer hos de patienter med sällsynta genetiska sjukdomar jag träffar i mitt arbete som specialistläkare i klinisk genetik. Med ny genteknik som exom- och helgenom- sekvensering kan vi snabbt kartlägga genetiken hos patienterna och identifiera misstänkta sjukdomsgener. För att stärka kopplingen mellan genetisk förändring och kliniska symtom utförs sedan funktionella studier i patientprov, cellinjer samt i zebrafisk. Våra fynd förs sedan tillbaka till vården i form av ny information om geners funktion och som genetisk rådgivning till den specifika familjen.
Forskargruppsledare för gruppen Sällsynta diagnoser, Institutionen för molekylär medicin och kirurgi
Forskningsbeskrivning
Se den engelska sidan för mer information
Artiklar
- Article: NATURE GENETICS. 2024;:1-8
- Journal article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2024;64 Suppl 1:289-290
- Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2024;103(8):1564-1569
- Article: CELL GENOMICS. 2024;4(7):100590
- Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2024;63(5):658-663
- Article: SCIENTIFIC REPORTS. 2024;14(1):9000
- Article: OPHTHALMIC GENETICS. 2024;45(1):95-102
- Journal article: GENETICS IN MEDICINE OPEN. 2024;2:101863
- Journal article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2023;62:159
- Article: BMC OPHTHALMOLOGY. 2023;23(1):394
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2023;191(7):1929-1934
- Article: JOURNAL OF INTERNAL MEDICINE. 2023;294(1):96-109
- Article: JOURNAL OF PEDIATRIC UROLOGY. 2023;19(3):335-338
- Article: SCIENTIFIC REPORTS. 2023;13(1):6904
- Journal article: PATHOLOGY. 2023;55:s17
- Journal article: PATHOLOGY. 2023;55:s19
- Journal article: PATHOLOGY. 2023;55:s19-s20
- Article: PLOS ONE. 2023;18(7):e0289346
- Article: FRONTIERS IN NEUROSCIENCE. 2023;17:1205653
- Article: FRONTIERS IN NEUROLOGY. 2023;14:1170005
- Article: FRONTIERS IN GENETICS. 2023;14:1174046
- Article: BIOMEDICINES. 2022;10(12):3171
- Article: HUMAN MUTATION. 2022;43(11):1567-1575
- Article: GENETICS IN MEDICINE. 2022;24(11):2296-2307
- Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2022;60(4):487-493
- Article: BLOOD ADVANCES. 2022;6(17):5009-5023
- Article: SEMINARS IN CANCER BIOLOGY. 2022;84:242-254
- Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(16):9392
- Article: HUMAN MUTATION. 2022;43(6):708-716
- Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2022;10(4):e1880
- Journal article: EUROPEAN JOURNAL OF MEDICAL GENETICS. 2022;65(1):104402
- Article: FRONTIERS IN GENETICS. 2022;13:839349
- Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2021;297(6):101355
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2021;185(12):3593-3600
- Article: JOURNAL OF HUMAN GENETICS. 2021;66(10):995-1008
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2021;29(9):1359-1368
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2021;29(9):1337-1347
- Article: LAKARTIDNINGEN. 2021;118:21015
- Article: HUMAN GENETICS. 2021;140(5):775-790
- Article: GENETICS IN MEDICINE. 2021;23(5):888-899
- Article: GENOME MEDICINE. 2021;13(1):63
- Article: GENOME MEDICINE. 2021;13(1):40
- Article: FRONTIERS IN GENETICS. 2021;12:708348
- Article: FRONTIERS IN GENETICS. 2021;12:803683
- Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2020;38(5):692-706
- Article: HUMAN MUTATION. 2020;41(11):1979-1998
- Article: LAKARTIDNINGEN. 2020;117:19238
- Article: NATURE COMMUNICATIONS. 2020;11(1):4932
- Article: BMC BIOINFORMATICS. 2020;21(1):273
- Article: BMC MEDICAL GENETICS. 2020;21(1):87
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2020;182(5):1143-1151
- Article: LAKARTIDNINGEN. 2020;117:FU7F
- Article: MOLECULAR BIOLOGY AND EVOLUTION. 2020;37(1):18-30
- Article: PLOS ONE. 2020;15(2):e0228622
- Article: CLINICAL GENETICS. 2019;96(6):560-565
- Article: SCIENCE ADVANCES. 2019;5(9):eaax2166
- Article: CLINICAL GENETICS. 2019;96(2):118-125
- Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2019;7(6):e666
- Article: NATURE MEDICINE. 2019;25(4):583-590
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2019;104(3):530-541
- Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2019;7(3):e549
- Article: BIOLOGICAL PSYCHIATRY. 2019;85(4):287-297
- Article: PLOS GENETICS. 2019;15(2):e1007858
- Article: FRONTIERS IN GENETICS. 2019;10:608
- Article: FRONTIERS IN GENETICS. 2019;10:896
- Article: PLOS GENETICS. 2018;14(11):e1007780
- Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2018;812:1-4
- Article: HUMAN MUTATION. 2018;39(10):1456-1467
- Article: HUMAN MUTATION. 2018;39(9):1161-1172
- Article: HUMAN MUTATION. 2018;39(7):939-946
- Article: HUMAN MUTATION. 2018;39(4):495-505
- Article: FRONTIERS IN ENDOCRINOLOGY. 2018;9:380
- Article: PLOS ONE. 2018;13(3):e0189710
- Article: PLOS ONE. 2018;13(3):e0193928
- Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2017;32(12):2394-2404
- Article: SCIENTIFIC REPORTS. 2017;7(1):15585
- Article: NATURE NEUROSCIENCE. 2017;20(8):1043-1051
- Article: JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2017;102(8):3029-3039
- Journal article: F1000RESEARCH. 2017;6:664
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2017;173(5):1396-1399
- Article: NATURE GENETICS. 2017;49(4):515-526
- Article: JOURNAL OF BONE AND MINERAL RESEARCH. 2017;32(4):776-783
- Article: HUMAN GENETICS. 2017;136(2):179-192
- Article: F1000RESEARCH. 2017;6:664
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2016;99(5):1005-1014
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2016;99(2):318-336
- Article: EUROPEAN JOURNAL OF HUMAN GENETICS. 2016;24(2):198-207
- Article: HUMAN MOLECULAR GENETICS. 2015;24(18):5069-5078
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2015;96(3):507-513
- Article: JOURNAL OF MEDICAL GENETICS. 2015;52(2):111-122
- Article: PLOS ONE. 2015;10(7):e0131883
- Article: MOLECULAR GENETICS & GENOMIC MEDICINE. 2014;2(5):402-411
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2014;94(5):745-754
- Article: JOURNAL OF MEDICAL GENETICS. 2014;51(1):45-54
- Article: AMERICAN JOURNAL OF HUMAN GENETICS. 2013;93(2):357-367
- Article: JOURNAL OF MEDICAL GENETICS. 2013;50(8):521-528
- Article: CELL. 2012;150(3):533-548
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2012;158A(5):1111-1117
- Article: CLINICAL GENETICS. 2010;77(6):552-562
- Article: JOURNAL OF MEDICAL GENETICS. 2010;47(5):299-311
- Article: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2010;152A(5):1233-1243
- Article: CLINICAL GENETICS. 2010;77(2):145-154
- Journal article: EUROPEAN JOURNAL OF MEDICAL GENETICS. 2005;48(4):454-455
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Alla övriga publikationer
- Preprint: MEDRXIV. 2024;MEDRXIV
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:606
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:603-604
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:472-473
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:539
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:689
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:643
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:629
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2024;32:523-524
- Review: JOURNAL OF INTERNAL MEDICINE. 2023;294(4):397-412
- Preprint: RESEARCH SQUARE. 2023
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:348-349
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:646
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:48
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:469
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:576-577
- Published conference paper: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:429Missense variant in PDK1 associated with severe developmental delay and epilepsy
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:632
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:444
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:451
- Review: CAMB PRISM PRECIS MED. 2023;1:e15
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2023;31:590-591
- Review: TRENDS IN GENETICS. 2022;38(11):1134-1146
- Letter: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2022;60(4):586
- Letter: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2022;60(4):585-586
- Letter: NATURE MEDICINE. 2022;28(10):1980-1982
- Other: CLINICAL CASE REPORTS. 2022;10(6):e5989
- Conference publication: ANNALS OF NEUROLOGY. 2022;92:S171-S172
- Conference publication: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 2022;63(7)
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2022;30(SUPPL 1):440
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2022;30(SUPPL 1):236-237
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2022;30(SUPPL 1):41-42
- Book chapter: XIIITH INTERNATIONAL SYMPOSIUM ON SPERMATOLOGY. 2021;p. 125
- Corrigendum: NATURE COMMUNICATIONS. 2020;11(1):5398
- Conference publication: FASEB JOURNAL. 2020;34:1
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):331-332
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):117-118
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):605-606
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):908-909
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):3-4
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):254
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):588
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2020;28(SUPPL 1):52-53
- Conference publication: 2019
- Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2019;20(6):E1296-1296
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1272
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1666
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1659
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:123-124
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1070
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1830
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1519-1520
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1666-1667
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1533
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1143
- Conference publication: MOLECULAR CYTOGENETICS. 2019;12
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1766
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2019;27:1137-1138
- Conference publication: MOLECULAR CYTOGENETICS. 2019;12
- Preprint: BIORXIV. 2018
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:510-511
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:211
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:590-591
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:677
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:675
- Conference publication: EUROPEAN JOURNAL OF HUMAN GENETICS. 2018;26:60
- Editorial comment: BASIC AND CLINICAL ANDROLOGY. 2018;28:13
- Conference publication: BONE ABSTRACTS. 2017
- Conference publication: MOLECULAR CYTOGENETICS. 2017;10
- Letter: CLINICAL GENETICS. 2015;87(5):496-498
- Thesis / dissertation: 2009
- Conference publication: HORMONE RESEARCH IN PAEDIATRICS. 2009;72:241
- Conference publication: CHROMOSOME RESEARCH. 2009;17:92
- Conference publication: CHROMOSOME RESEARCH. 2009;17:92-93
- Letter: AMERICAN JOURNAL OF MEDICAL GENETICS PART A. 2008;146A(24):3217-3222
- Conference publication: CELLULAR ONCOLOGY. 2007;29(2):148
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Forskningsbidrag
- Swedish Research Council1 January 2023 - 31 December 2026
- Swedish Cancer Society1 January 2022
- Swedish Research Council1 January 2020 - 31 December 2025
- Congenital skeletal disorders: identification of molecular mechanisms and clinical characterisation.Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2019 - 31 December 2021
- Swedish Research Council1 January 2018 - 31 December 2021
- Zebrafish studies to develop new treatments for drug-resistant leukemiaSwedish Cancer Society1 January 2018
- Swedish Research Council1 January 2013 - 31 December 2015
- Swedish Research Council1 September 2012 - 31 August 2013
Anställningar
- Överläkare, Klinisk genetik och genomik, Karolinska University Hospital, 2019-
- Director Clinical Genetics Laboratory, Clinical Genetics and Genomics, Karolinska University Hospital, 2018-
- Adjungerad Professor, Molekylär medicin och kirurgi, Karolinska Institutet, 2020-2024
- Specialist physician, Clinical Genetics and Genomics, Karolinska University Hospital, 2012-2019
- Resident, Clinical genetics and Genomics, Karolinska University Hospital, 2002-2012
Examina och utbildning
- Docent, Klinisk genetik, Karolinska Institutet, 2016
- Medicine Doktorsexamen, Institutionen för molekylär medicin och kirurgi, Karolinska Institutet, 2010
- Läkarexamen, Karolinska Institutet, 1999
Handledare
- Esmee ten Berk de Boer, 2023
- Elin Stavrén Eriksson, 2023
- Olivia Henry, 2022
- Ida Nordgren, 2021
- Marlene Ek, 2021
- Kristine Bilgrav Saether, 2021
- Hillevi Lindelöf, 2020
- Emma Ehn, 2019
- Emelie Ponten, 2017
- Dominyka Batkovskyte, Genetic studies of rare skeletal disorders : to solve the unsolved, https://openarchive.ki.se/articles/thesis/Genetic_studies_of_rare_skeletal_disorders_to_solve_the_unsolved/26903353?file=48945721
- Karin Salehi, Molecular and clinical studies of intestinal malrotation, https://openarchive.ki.se/articles/thesis/Molecular_and_clinical_studies_of_intestinal_malrotation/26912176?file=48956170
- Samara Arkani, Molecular and epidemiological studies of bladder exstrophy and epispadias complex, https://dspace.kib.ki.se/xmlui/handle/10616/48566
- Anna Hammarsjö, EXPANDING THE GENETIC AND PHENOTYPIC SPECTRUM OF SKELETAL DYSPLASIAS
- Anders Kämpe, Genetic causes and underlying disease mechanisms in early-onset osteoporosis, https://openarchive.ki.se/articles/thesis/Genetic_causes_and_underlying_disease_mechanisms_in_early-onset_osteoporosis/26919550?file=48964903
- Maria Pettersson, STRUCTURAL GENOMIC VARIATION IN HUMAN DISEASE, https://openarchive.ki.se/articles/thesis/Structural_genomic_variation_in_human_disease/26917915?file=48962779
- Jesper Eisfeldt, Characterization of structural chromosomal variants by massive parallel sequencing
- Sofia Frisk, Studies of Genetic Mosaicism in Rare Diseases
- Jakob Schuy, Studies of structural chromosome rearrangments to identify genes involved in congenital brain disorders
Gästforskning och resestipendier
- Visiting professor, Pacific Northwest Diabetes Research Institute, 1 month visiting professor, 2024-2024
- Postdoctoral Researcher, Duke University, 2 year VR funder postdoc, focus on ciliopathies, CNV screening and zebrafish modelling, 2010-2012