Aline Pfefferle

Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Artiklar

Article: NATURE IMMUNOLOGY. 2024;25(8):1445-1459
Pan-cancer profiling of tumor-infiltrating natural killer cells through transcriptional reference mapping
Netskar H; Pfefferle A; Goodridge JP; Sohlberg E; Dufva O; Teichmann SA; Brownlie D; Michaelsson J; Marquardt N; Clancy T; Horowitz A; Malmberg K-J
Journal article: EMBO JOURNAL. 2024;43(13):2527-2529
Egr2 to the rescue: nanoparticles revitalize natural killer cells in the fight against cancer
Pfefferle A; Phuyal S; Netskar H; Malmberg K-J
Article: NATURE IMMUNOLOGY. 2024;25(2):240-255
IKAROS and AIOLOS directly regulate AP-1 transcriptional complexes and are essential for NK cell development
Goh W; Sudholz H; Foroutan M; Scheer S; Pfefferle A; Delconte RB; Meng X; Shen Z; Hennessey R; Kong IY; Schuster IS; Andoniou CE; Davis MJ; Hediyeh-Zadeh S; Souza-Fonseca-Guimaraes F; Parish IA; Beavis P; Thiele D; Chopin M; Degli-Esposti MA; Cursons J; Kallies A; Rautela J; Nutt SL; Huntington ND
Article: CLINICAL & TRANSLATIONAL IMMUNOLOGY. 2024;13(5):e1507
Optimisation of a primary human CAR-NK cell manufacturing pipeline
Pfefferle A; Contet J; Wong K; Chen C; Verhoeyen E; Slichter CK; Schluns KS; Cursons J; Berry R; Nikolic I; Rautela J; Huntington ND
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2023;29(6):376.e1-376.e11
Effect of mTOR Inhibition with Sirolimus on Natural Killer Cell Reconstitution in Allogeneic Stem Cell Transplantation
Haroun-Izquierdo A; Lanuza PM; Pfefferle A; Netskar H; Ask EH; Torlen J; Bjorklund A; Sohlberg E; Malmberg K-J
Article: BLOOD. 2022;139(5):704-716
Perturbed NK-cell homeostasis associated with disease severity in chronic neutropenia
Sohlberg E; Pfefferle A; Ask EH; Tschan-Plessl A; Jacobs B; Netskar H; Lorenz S; Kanaya M; Kosugi-Kanaya M; Meinke S; Mortberg A; Hoglund P; Sundin M; Carlsson G; Palmblad J; Malmberg K-J
Article: CANCER IMMUNOLOGY RESEARCH. 2021;9(10):1125-1140
The Ratio of Exhausted to Resident Infiltrating Lymphocytes Is Prognostic for Colorectal Cancer Patient Outcome
Foroutan M; Molania R; Pfefferle A; Behrenbruch C; Scheer S; Kallies A; Speed TP; Cursons J; Huntington ND
Article: CELL REPORTS. 2019;29(8):2284-2294.e4
Intra-lineage Plasticity and Functional Reprogramming Maintain Natural Killer Cell Repertoire Diversity
Pfefferle A; Jacobs B; Netskar H; Ask EH; Lorenz S; Clancy T; Goodridge JP; Sohlberg E; Malmberg K-J
Article: JOURNAL OF IMMUNOLOGY. 2019;202(3):736-746
Induction of the BIM Short Splice Variant Sensitizes Proliferating NK Cells to IL-15 Withdrawal
Jacobs B; Pfefferle A; Clement D; Berg-Larsen A; Saetersmoen ML; Lorenz S; Wiiger MT; Goodridge JP; Malmberg K-J
Article: NATURE COMMUNICATIONS. 2019;10(1):514
Remodeling of secretory lysosomes during education tunes functional potential in NK cells
Goodridge JP; Jacobs B; Saetersmoen ML; Clement D; Hammer Q; Clancy T; Skarpen E; Brech A; Landskron J; Grimm C; Pfefferle A; Meza-Zepeda L; Lorenz S; Wiiger MT; Louch WE; Ask EH; Liu LL; Oei VYS; Kjallquist U; Linnarsson S; Patel S; Tasken K; Stenmark H; Malmberg K-J
Article: CANCER IMMUNOLOGY RESEARCH. 2017;5(8):654-665
Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells
Liu LL; Beziat V; Oei VYS; Pfefferle A; Schaffer M; Lehmann S; Hellstrom-Lindberg E; Soderhall S; Heyman M; Grander D; Malmberg K-J
Article: ONCOTARGET. 2015;6(33):34178-34190
Imprint of 5-azacytidine on the natural killer cell repertoire during systemic treatment for high-risk myelodysplastic syndrome
Sohlberg E; Pfefferle A; Andersson S; Baumann BC; Hellstrom-Lindberg E; Malmberg K-J
Article: CLINICAL CANCER RESEARCH. 2014;20(22):5733-5744
Human Anaplastic Thyroid Carcinoma Cells Are Sensitive to NK Cell-Mediated Lysis via ULBP2/5/6 and Chemoattract NK Cells
Wennerberg E; Pfefferle A; Ekblad L; Yoshimoto Y; Kremer V; Kaminskyy VO; Juhlin CC; Hoog A; Bodin I; Svjatoha V; Larsson C; Zedenius J; Wennerberg J; Lundqvist A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(3):1060-1065
Toso controls encephalitogenic immune responses by dendritic cells and regulatory T cells
Brenner D; Bruestle A; Lin GHY; Lang PA; Duncan GS; Knobbe-Thomsen CB; Paul MS; Reardon C; Tusche MW; Snow B; Hamilton SR; Pfefferle A; Gilani SO; Ohashi PS; Lang KS; Mak TW
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2013;1833(1):80-89
Glutathionylation of UCP2 sensitizes drug resistant leukemia cells to chemotherapeutics
Pfefferle A; Mailloux RJ; Adjeitey CN-K; Harper M-E

Alla övriga publikationer

Review: CANCERS. 2020;12(3):E706-706
You Have Got a Fast CAR: Chimeric Antigen Receptor NK Cells in Cancer Therapy
Pfefferle A; Huntington ND
Review: FRONTIERS IN IMMUNOLOGY. 2020;11:812
Deciphering Natural Killer Cell Homeostasis
Pfefferle A; Jacobs B; Haroun-Izquierdo A; Kveberg L; Sohlberg E; Malmberg K-J
Thesis / dissertation: 2019
Dynamics of natural killer cell homeostasis : implications for cell-based cancer immunotherapy
Pfefferle, Aline
Review: MOLECULAR ONCOLOGY. 2015;9(10):1904-1917
Harnessing adaptive natural killer cells in cancer immunotherapy
Liu LL; Pfefferle A; Sheng VOY; Bjorklund AT; Beziat V; Goodridge JP; Malmberg KJ

Forskningsbidrag

PÅ INSIDAN AV EN MÖRDARE - vesikulär transportdynamik i naturliga mördarceller
Harald Jeanssons Stiftelse & Harald och Greta Jeanssons Stiftelse
På insidan av en mördare - vesikulär transportdynamik i naturliga mördarceller
KI Forskningsbidrag

Anställningar

Biträdande Lektor, Medicin, Huddinge, Karolinska Institutet, 2024-2030
Postdoktor, Medicin, Huddinge, Karolinska Institutet, 2022-2024
Research Fellow, Biomedicine Discovery Institute, Monash University, 2019-2022
Senior Scientist, oNKo-innate Pty Ltd, 2019-2022
Summer Research Student, The Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, 2011-2011
Summer Research Student, The Campbell Family Cancer Research Institute, Princess Margaret Cancer Centre, 2010-2010

Examina och utbildning

Medicine Doktorsexamen, Medical Science, Dynamics of Natural Killer Cell Homeostasis - Implications for Cell-Based Cancer Immunotherapy, Institutionen för medicin, Huddinge, Karolinska Institutet, 2019
Medicine Masterexamen, Biomedicine, The role of semaphorin 3A in re-educating macrophages and their cross-talk with natural killer cells, Karolinska Institutet, 2014
Bachelor of Science, Honours in Biopharmaceutical Sciences: Genomics Option, Manipulation of redox state and sensitization of drug resistant cancer cells to chemotherapeutics: role for UCP2?, Department of Biochemistry, Microbiology & Immunology, University of Ottawa, 2012

Artiklar

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Forskningsbidrag

Anställningar

Examina och utbildning

Nyheter från KI

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