Ali Moshfegh

Publikationer
CV
Populärvetenskap och samverkan

Artiklar

Article: IMMUNITY. 2023;56(5):979-997.e11
The RNA editor ADAR2 promotes immune cell trafficking by enhancing endothelial responses to interleukin-6 during sterile inflammation
Gatsiou A; Tual-Chalot S; Napoli M; Ortega-Gomez A; Regen T; Badolia R; Cesarini V; Garcia-Gonzalez C; Chevre R; Ciliberti G; Silvestre-Roig C; Martini M; Hoffmann J; Hamouche R; Visker JR; Diakos N; Wietelmann A; Silvestris DA; Georgiopoulos G; Moshfegh A; Schneider A; Chan W; Guenther S; Backs J; Kwak S; Selzman CH; Stamatelopoulos K; Rose-John S; Trautwein C; Spyridopoulos I; Braun T; Waisman A; Gallo A; Drakos SG; Dimmeler S; Sperandio M; Soehnlein O; Stellos K
Article: PHARMACEUTICS. 2023;15(4):1148
A Small Molecule Targeting the Intracellular Tyrosine Kinase Domain of ROR1 (KAN0441571C) Induced Significant Apoptosis of Non-Small Cell Lung Cancer (NSCLC) Cells
Ghaderi A; Okhovat M-A; Lehto J; De Petris L; Doulabi EM; Kokhaei P; Zhong W; Rassidakis GZ; Drakos E; Moshfegh A; Schultz J; Olin T; Osterborg A; Mellstedt H; Hojjat-Farsangi M
Article: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2021;269:75-99
Targeting the Receptor Tyrosine Kinase ROR1 by Small Molecules.
Hojjat-Farsangi M; Moshfegh A; Schultz J; Norin M; Olin T; Österborg A; Mellstedt H
Article: BIOMEDICINES. 2020;8(6):E170-170
ROR1 is Expressed in Diffuse Large B-Cell Lymphoma (DLBCL) and a Small Molecule Inhibitor of ROR1 (KAN0441571C) Induced Apoptosis of Lymphoma Cells
Ghaderi A; Daneshmanesh AH; Moshfegh A; Kokhaei P; Vagberg J; Schultz J; Olin T; Harrysson S; Smedby KE; Drakos E; Rassidakis GZ; Osterborg A; Mellstedt H; Hojjat-Farsangi M
Article: LEUKEMIA. 2018;32(10):2291-2295
First-in-class oral small molecule inhibitor of the tyrosine kinase ROR1 (KAN0439834) induced significant apoptosis of chronic lymphocytic leukemia cells
Hojjat-Farsangi M; Daneshmanesh AH; Khan AS; Shetye J; Mozaffari F; Kharaziha P; Rathje L-S; Kokhaei P; Hansson L; Vagberg J; Bystrom S; Olsson E; Lofberg C; Norstrom C; Schultz J; Norin M; Olin T; Osterborg A; Mellstedt H; Moshfegh A
Article: PLOS ONE. 2018;13(6):e0198038
A receptor tyrosine kinase ROR1 inhibitor (KAN0439834) induced significant apoptosis of pancreatic cells which was enhanced by erlotinib and ibrutinib
Daneshmanesh AH; Hojjat-Farsangi M; Ghaderi A; Moshfegh A; Hansson L; Schultz J; Vagberga J; Bystrom S; Olsson E; Olin T; Osterborg A; Mellstedt H
Article: PLOS ONE. 2018;13(2):e0192839
Autologous T cells expressing the oncogenic transcription factor KLF6-SV1 prevent apoptosis of chronic lymphocytic leukemia cells
Kokhaei P; Hojjat-Farsangi M; Mozaffari F; Moshfegh A; Pak F; Rashidy-Pour A; Palma M; Hansson L; Osterborg A; Mellstedt H
Article: BMC NEPHROLOGY. 2017;18(1):161
Vitamin D receptor activation reduces inflammatory cytokines and plasma MicroRNAs in moderate chronic kidney disease - a randomized trial
Mansouri L; Lundwall K; Moshfegh A; Jacobson SH; Lundahl J; Spaak J
Article: JOURNAL OF DIABETES AND ITS COMPLICATIONS. 2017;31(1):4-12
Mono-epoxy-tocotrienol-α enhances wound healing in diabetic mice and stimulates in vitro angiogenesis and cell migration
Xu C; Bentinger M; Savu O; Moshfegh A; Sunkari V; Dallner G; Swiezewska E; Catrina S-B; Brismar K; Tekle M
Article: PLOS ONE. 2017;12(11):e0187294
Flavin-containing monooxygenase 3 (FMO3) role in busulphan metabolic pathway
El-Serafi I; Terelius Y; Abedi-Valugerdi M; Naughton S; Saghafian M; Moshfegh A; Mattsson J; Potacova Z; Hassan M
Article: ONCOLOGY LETTERS. 2016;12(4):2782-2788
Differential expression of viral agents in lymphoma tissues of patients with ABC diffuse large B-cell lymphoma from high and low endemic infectious disease regions
Hogfeldt T; Jaing C; Mc Loughlin K; Thissen J; Gardner S; Bahnassy AA; Gharizadeh B; Lundahl J; Osterborg A; Porwit A; Zekri A-RN; Khaled HM; Mellstedt H; Moshfegh A
Article: TUMOR BIOLOGY. 2016;37(9):11947-11957
Dishevelled proteins are significantly upregulated in chronic lymphocytic leukaemia
Khan AS; Hojjat-Farsangi M; Daneshmanesh AH; Hansson L; Kokhaei P; Osterborg A; Mellstedt H; Moshfegh A
Article: PHARMACOGENOMICS JOURNAL. 2015;15(5):405-413
Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies
El-Serafi I; Fares M; Abedi-Valugerdi M; Afsharian P; Moshfegh A; Terelius Y; Potacova Z; Hassan M
Article: PLOS ONE. 2015;10(11):e0142310
Spontaneous Immunity Against the Receptor Tyrosine Kinase ROR1 in Patients with Chronic Lymphocytic Leukemia.
Hojjat-Farsangi M; Jeddi-Tehrani M; Daneshmanesh AH; Mozaffari F; Moshfegh A; Hansson L; Razavi SM; Sharifian RA; Rabbani H; Österborg A; Mellstedt H; Shokri F
Article: PLOS ONE. 2015;10(11):e0141979
Cytochrome P450 Oxidoreductase Influences CYP2B6 Activity in Cyclophosphamide Bioactivation
El-Serafi I; Afsharian P; Moshfegh A; Hassan M; Terelius Y
Article: LEUKEMIA AND LYMPHOMA. 2014;55(5):1158-1165
Expression of microRNA-1234 related signal transducer and activator of transcription 3 in patients with diffuse large B-cell lymphoma of activated B-cell like type from high and low infectious disease areas
Hoegfeldt T; Johnsson P; Grander D; Bahnassy AA; Porwit A; Eid S; Osterborg A; Zekri A-RN; Lundahl J; Khaled MH; Mellstedt H; Moshfegh A
Article: PLOS ONE. 2014;9(1):e86619
Cyclophosphamide Alters the Gene Expression Profile in Patients Treated with High Doses Prior to Stem Cell Transplantation
El-Serafi I; Abedi-Valugerdi M; Potacova Z; Afsharian P; Mattsson J; Moshfegh A; Hassan M
Article: LEUKEMIA AND LYMPHOMA. 2013;54(5):996-1003
Patients with activated B-cell like diffuse large B-cell lymphoma in high and low infectious disease areas have different inflammatory gene signatures
Hogfeldt T; Bahnassy AA; Kwiecinska A; Osterborg A; Tamm KP; Porwit A; Zekri A-RN; Lundahl J; Khaled HM; Mellstedt H; Moshfegh A
Article: BONE MARROW TRANSPLANTATION. 2013;48(2):284-293
Early-phase GVHD gene expression profile in target versus non-target tissues: kidney, a possible target?
Sadeghi B; Al-Chaqmaqchi H; Al-Hashmi S; Brodin D; Hassan Z; Abedi-Valugerdi M; Moshfegh A; Hassan M
Article: CELL DEATH AND DISEASE. 2013;4(1):e454
Inhibition of Ephrin B3-mediated survival signaling contributes to increased cell death response of non-small cell lung carcinoma cells after combined treatment with ionizing radiation and PKC 412
Stahl S; Kaminskyy VO; Efazat G; Vaculova AH; Rodriguez-Nieto S; Moshfegh A; Lewensohn R; Viktorsson K; Zhivotovsky B
Article: PLOS ONE. 2013;8(7):e68937
Activation of Wnt/β-Catenin Pathway in Monocytes Derived from Chronic Kidney Disease Patients
Al-Chaqmaqchi HAM; Moshfegh A; Dadfar E; Paulsson J; Hassan M; Jacobson SH; Lundahl J
Article: PLOS ONE. 2013;8(4):e60367
The Role of Programmed Cell Death Ligand-1 (PD-L1/CD274) in the Development of Graft versus Host Disease
Al-Chaqmaqchi H; Sadeghi B; Abedi-Valugerdi M; Al-Hashmi S; Fares M; Kuiper R; Lundahl J; Hassan M; Moshfegh A
Article: PLOS ONE. 2013;8(8):e73141
Leukocyte Proliferation and Immune Modulator Production in Patients with Chronic Kidney Disease
Mansouri L; Paulsson JM; Moshfegh A; Jacobson SH; Lundahl J
Article: CANCER IMMUNOLOGY, IMMUNOTHERAPY. 2013;62(1):51-63
T cells from indolent CLL patients prevent apoptosis of leukemic B cells in vitro and have altered gene expression profile
Kiaii S; Kokhaei P; Mozaffari F; Rossmann E; Pak F; Moshfegh A; Palma M; Hansson L; Mashayekhi K; Hojjat-Farsangi M; Osterborg A; Choudhury A; Mellstedt H
Article: PLOS ONE. 2013;8(10):e78339
The tyrosine kinase receptor ROR1 is constitutively phosphorylated in chronic lymphocytic leukemia (CLL) cells.
Hojjat-Farsangi M; Khan AS; Daneshmanesh AH; Moshfegh A; Sandin A; Mansouri L; Palma M; Lundin J; Österborg A; Mellstedt H
Article: JOURNAL OF CLINICAL ONCOLOGY. 2012;30(29):3633-3639
Targeting p53 in Vivo: A First-in-Human Study With p53-Targeting Compound APR-246 in Refractory Hematologic Malignancies and Prostate Cancer
Lehmann S; Bykov VJN; Ali D; Andren O; Cherif H; Tidefelt U; Uggla B; Yachnin J; Juliusson G; Moshfegh A; Paul C; Wiman KG; Andersson P-O
Article: BRITISH JOURNAL OF CANCER. 2012;107(8):1361-1373
miRNA-214 modulates radiotherapy response of non-small cell lung cancer cells through regulation of p38MAPK, apoptosis and senescence
Salim H; Akbar NS; Zong D; Vaculova AH; Lewensohn R; Moshfegh A; Viktorsson K; Zhivotovsky B
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2012;168(1):105-112
In-vivo extravasation induces the expression of interleukin 1 receptor type 1 in human neutrophils
Paulsson JM; Moshfegh A; Dadfar E; Held C; Jacobson SH; Lundahl J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2011;411(1):156-161
The pattern of gene expression and gene dose profiles of 6-Mercaptopurine- and 6-Thioguanine-resistant human leukemia cells
Karim H; Hashemi J; Larsson C; Moshfegh A; Fotoohi AK; Albertioni F
Article: NEPHROLOGY DIALYSIS TRANSPLANTATION. 2011;26(7):2195-2201
Expression of neutrophil SOD2 is reduced after lipopolysaccharide stimulation: a potential cause of neutrophil dysfunction in chronic kidney disease
Olsson J; Jacobson TAS; Paulsson JM; Dadfar E; Moshfegh A; Jacobson SH; Lundahl J
Article: INTERNATIONAL JOURNAL OF ONCOLOGY. 2011;38(4):1075-1081
Gene expression analysis using long-term preserved formalin-fixed and paraffin-embedded tissue of non-small cell lung cancer
Jacobson TAS; Lundahl J; Mellstedt H; Moshfegh A
Article: ONCOGENE. 2010;29(9):1329-1338
Mutant p53 reactivation by PRIMA-1^MET induces multiple signaling pathways converging on apoptosis
Lambert JMR; Moshfegh A; Hainaut P; Wiman KG; Bykov VJN
Article: BIOCHEMICAL PHARMACOLOGY. 2009;77(8):1410-1417
Gene expression profiling of leukemia T-cells resistant to methotrexate and 7-hydroxymethotrexate reveals alterations that preserve intracellular levels of folate and nucleotide biosynthesis
Fotoohi AK; Assaraf YG; Moshfegh A; Hashemi J; Jansen G; Peters GJ; Larsson C; Albertioni F
Article: BLOOD PURIFICATION. 2009;28(1):47-52
Monocyte and Neutrophil Chemotactic Activity at the Site of Interstitial Inflammation in Patients on High-Flux Hemodialysis or Hemodiafiltration
Olsson J; Paulsson J; Dadfar E; Lundahl J; Moshfegh A; Jacobson SH
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2007;18(8):643-651
The stress of birth enhances in vitro spontaneous and IL-8-induced neutrophil chemotaxis in the human newborn
Yektaei-Karin E; Moshfegh A; Lundahl J; Berggren V; Hansson L-O; Marchini G
Article: CLINICAL CANCER RESEARCH. 2007;13(5):1503-1510
Long-term idiotype vaccination combined with interleukin-12 (IL-12), or IL-12 and granulocyte macrophage colony-stimulating factor, in early-stage multiple myeloma patients
Hansson L; Abdalla AO; Moshfegh A; Choudhury A; Rabbani H; Nilsson B; Osterborg A; Mellstedt H
Article: KIDNEY INTERNATIONAL. 2007;71(6):582-588
Preserved leukocyte CD11b expression at the site of interstitial inflammation in patients with high-flux hemodiafiltration
Olsson J; Dadfar E; Paulsson J; Lundahl J; Moshfegh A; Jacobson SH
Article: BIOCHEMICAL PHARMACOLOGY. 2006;72(7):816-823
Molecular mechanisms underlying the enhanced sensitivity of thiopurine-resistant T-lymphoblastic cell lines to methyl mercaptopurineriboside
Fotoohi AK; Wrabel A; Moshfegh A; Peterson C; Albertioni F
Article: PEDIATRIC RESEARCH. 2005;58(1):138-142
Neonatal eosinophils possess efficient eotaxin/IL-5-and N-formyl-methionyl-leucyl-phenylalanine-induced transmigration in vitro
Moshfegh A; Lothian C; Halldén G; Marchini G; Lagercrantz H; Lundahl J
Article: LEUKEMIA. 2004;18(11):1810-1815
Apoptotic tumor cells are superior to tumor cell lysate, and tumor cell RNA in induction of autologous T cell response in B-CLL
Kokhaei P; Choudhury A; Mahdian R; Lundin J; Moshfegh A; Österborg A; Mellstedt H
Article: EUROPEAN RESPIRATORY JOURNAL. 2003;21(4):646-651
Lung accumulations of eosinophil granulocytes after exposure to cornstarch glove powder
Grunewald J; Eklund A; Katchar K; Moshfegh A; Lidén C; Lundgren L; Skare L; Tornling G
Article: ALLERGY. EUROPEAN JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2002;57(12):1200-1204
Increased eosinophil transmigration after nasal allergen challenge in children with allergic asthma and rhinitis
Lönnkvist K; Moshfegh A; Pedroletti C; Hedlin G; Halldén G; Lundahl J
Article: NEPHRON. 2002;91(4):659-665
Impact of hemodialysis membrane and permeability on neutrophil transmigration in vitro
Moshfegh A; Jacobson SH; Halldén G; Thylén P; Lundahl J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;56(2):161-167
Distinct phenotypic adhesion molecule expression on human cord blood progenitors during early eosinophilic commitment:: Upregulation of β₇ integrins
Lundahl J; Sehmi R; Moshfegh A; Hayes L; Howie K; Upham J; Denburg JA
Article: INFLAMMATION. 2001;25(6):399-404
Increased expression of lymphocytes recruited CD25 and HLA-DR on into the peritoneal cavity in non-infected CAPD patients
Brauner A; Hylander B; Jacobson SH; Moshfegh A; Lundahl J
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1999;50(3):262-269
Methods for simultaneous quantitative analysis of eosinophil and neutrophil adhesion and transmigration
Moshfegh A; Halldén G; Lundahl J
Article: INFLAMMATION. 1998;22(2):123-135
Eotaxin increases the expression of CD11b/CD18 and adhesion properties in IL5, but not fMLP-prestimulated human peripheral blood eosinophils
Lundahl J; Moshfegh A; Grönneberg R; Halldén G
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Meeting abstract: ANNALS OF ONCOLOGY. 2016;27:vi530
First generation of a small chemical molecule ROR1 RTK tyrosine kinase inhibitor
Mellstedt H; Hojjat-Farsangi M; Daneshmanesh AH; Moshfegh A; Bystrom S; Norin M; Olin T; Schultz J; Vagberg J; Osterborg A
Meeting abstract: BLOOD. 2015;126(23):2912
First-in-Class ROR1 Small Molecule Inhibitor (KAN0439834) Downregulated Wnt-Canonical and Non-Canonical Signaling Pathways and Induced Apoptosis of CLL Cells
Hojjat-Farsangi M; Moshfegh A; Daneshmanesh AH; Vagberg J; Styrbjorn B; Schultz J; Olsson E; Lofberg C; Norstrom C; Norin M; Olin T; Osterborg A; Mellstedt H
Letter: BRITISH JOURNAL OF HAEMATOLOGY. 2015;169(3):455-458
The PI3K/AKT/mTOR pathway is involved in direct apoptosis of CLL cells induced by ROR1 monoclonal antibodies.
Daneshmanesh AH; Hojjat-Farsangi M; Moshfegh A; Khan AS; Mikaelsson E; Österborg A; Mellstedt H
Review: SEMINARS IN CANCER BIOLOGY. 2014;29:21-31
The receptor tyrosine kinase ROR1-An oncofetal antigen for targeted cancer therapy
Hojjat-Farsangi M; Moshfegh A; Daneshmanesh AH; Khan AS; Mikaelsson E; Osterborg A; Mellstedt H
Meeting abstract: CANCER RESEARCH. 2014;74(19):4770
Anti-ROR1 monoclonal antibodies induce apoptosis in pancreatic cancer cells via the PI3-kinase/AKT/mTOR pathway
Daneshmanesh AH; Hojjat-Farsangi M; Moshfegh A; Mikaelsson E; Khan AS; Osterborg A; Mellstedt H
Meeting abstract: JOURNAL OF CLINICAL ONCOLOGY. 2014;32(15):e13561
A new class of compound for pancreatic carcinoma targeting the tyrosine kinase receptor (TKR) ROR1.
Mellstedt H; Daneshmanesh AH; Moshfegh A; Farsangl MH; Khan S; Mlkaelsson E; Vagberg J; Systrom S; Schultz J; Olin T; Ostorborg A
Meeting abstract: BLOOD. 2012;120(21):4583
Dishevelled Proteins of Wnt Signaling Pathways Are Highly Expressed in Chronic Lymphocytic Leukemia
Khan AS; Sandin A; Osterborg A; Hojjat-Farsangi M; Mellstedt H; Moshfegh A
Meeting abstract: BLOOD. 2012;120(21):1769
Monoclonal Antibody Against ROR1 in Chronic Lymphocytic Leukemia Cells Induced Apoptosis Via PI3-Kinase/AKT/CREB Pathway
Daneshmanesh AH; Hojjat-Farsangi M; Sandin A; Khan AS; Moshfegh A; Jeddi-Tehrani M; Osterborg A; Mellstedt H
Meeting abstract: CANCER RESEARCH. 2012;72:3027
Dishevelled proteins are highly upregulated in chronic lymphocytic leukemia
Khan AS; Osterborg A; Moshfegh A; Mellstedt H
Meeting abstract: CANCER RESEARCH. 2011;71:5011
Difference in expression of STAT3 and STAT5b in Swedish and Egyptian patients with activated b-cell subtype of diffuse large b-cell lymphoma
Jacobson T; Bahnassy AA; Lundahl J; Tamm KP; Porwit A; Zekri A-RN; Khaled HM; Mellstedt H; Moshfegh A
Meeting abstract: ATHEROSCLEROSIS SUPPLEMENTS. 2010;11(2):100-101
NEUTROPHIL IL-1R AND CHEMOKINE EXPRESSION FOLLOWING IN VIVO EXTRAVASATION IN PATIENTS WITH CORONARY ARTERY DISEASE
Paulsson J; Moshfegh A; Dadfar E; Bygden-Nylander A; Held C; Jacobson S; Lundahl J
Meeting abstract: EJC SUPPLEMENTS. 2010;8(5):134
Global gene analysis reveals ephrin B3 as a potential radio sensitizing target in non small cell lung cancer cells
Stahl S; Vaculova A; Kaminskyy V; Rodriguez-Nieto S; Moshfegh A; Lewensohn R; Viktorsson K; Zhivotovsky B
Thesis / dissertation: 2001
The biological mechanisms in neutrophil and eosinophil adhesion and transmigration in vitro and theur relation to the inflammatory process in vivo
Moshfegh, Ali

Anställningar

Anknuten till Forskning, Onkologi-Patologi, Karolinska Institutet, 2024-2027

Examina och utbildning

MEDICINE DOKTORSEXAMEN, Institutionen för medicin, Solna, Karolinska Institutet, 2002
LICENTIATEXAMEN, INST F LABORATORIEMEDICIN (K5), Karolinska Institutet, 1999

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