Agneta Rannug

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Professor emerita i molekylär arbetsmiljömedicin.

Utvalda publikationer

Review: CHEMICAL REVIEWS. 2018;118(18):9058-9128
Chemistry and Properties of Indolocarbazoles
Janosik T; Rannug A; Rannug U; Wahlstrom N; Slatt J; Bergman J
Review: CRITICAL REVIEWS IN TOXICOLOGY. 2018;48(7):555-574
The tryptophan derivative 6-formylindolo[3,2-b]carbazole, FICZ, a dynamic mediator of endogenous aryl hydrocarbon receptor signaling, balances cell growth and differentiation
Rannug A; Rannug U
Review: PHARMACOLOGICAL REVIEWS. 2015;67(2):259-279
The Aryl Hydrocarbon Receptor in Barrier Organ Physiology, Immunology, and Toxicology
Esser C; Rannug A
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2012;109(12):4479-4484
Inhibition of cytochrome P4501-dependent clearance of the endogenous agonist FICZ as a mechanism for activation of the aryl hydrocarbon receptor
Wincent E; Bengtsson J; Bardbori AM; Alsberg T; Luecke S; Rannug U; Rannug A
Journal article: JOURNAL OF BIOLOGICAL CHEMISTRY. 1987;262(32):15422-15427
Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.
Rannug A; Rannug U; Rosenkranz HS; Winqvist L; Westerholm R; Agurell E; Grafström AK

Artiklar

Journal article: FRONTIERS IN TOXICOLOGY. 2022;4:775010
6-Formylindolo[3,2-b]carbazole, a Potent Ligand for the Aryl Hydrocarbon Receptor Produced Both Endogenously and by Microorganisms, can Either Promote or Restrain Inflammatory Responses
Rannug A
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2016;252:19-27
Chromatin remodeling by curcumin alters endogenous aryl hydrocarbon receptor signaling
Mohammadi-Bardbori A; Akbarizadeh AR; Delju F; Rannug A
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2016;29(1):75-86
Evidence for New Light-Independent Pathways for Generation of the Endogenous Aryl Hydrocarbon Receptor Agonist FICZ
Smirnova A; Wincent E; Bergander LV; Alsberg T; Bergman J; Rannug A; Rannug U
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2015;28(12):2278-2286
NADPH Oxidase-Dependent Mechanism Explains How Arsenic and Other Oxidants Can Activate Aryl Hydrocarbon Receptor Signaling
Mohammadi-Bardbori A; Bergander LV; Rannug U; Rannug A
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2014;224:183-188
Arsenic, cadmium, mercury and nickel stimulate cell growth via NADPH oxidase activation
Mohammadi-Bardbori A; Rannug A
Article: CHEMICAL RESEARCH IN TOXICOLOGY. 2012;25(9):1878-1884
Quercetin, Resveratrol, and Curcumin Are Indirect Activators of the Aryl Hydrocarbon Receptor (AHR)
Mohammadi-Bardbori A; Bengtsson J; Rannug U; Rannug A; Wincent E
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(1):203-210
The Aryl Hydrocarbon Receptor Mediates UVB Radiation-Induced Skin Tanning
Jux B; Kadow S; Luecke S; Rannug A; Krutmann J; Esser C
Article: PIGMENT CELL & MELANOMA RESEARCH. 2010;23(6):828-833
The aryl hydrocarbon receptor (AHR), a novel regulator of human melanogenesis
Luecke S; Backlund M; Jux B; Esser C; Krutmann J; Rannug A
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2010;184(3):466-473
Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor κB
Luecke S; Wincent E; Backlund M; Rannug U; Rannug A
Article: PHARMACOGENETICS AND GENOMICS. 2010;20(2):104-111
The GSTP1 lle105 Val polymorphism modifies the metabolism of toluene di-isocyanate
Broberg KE; Warholm M; Tinnerberg H; Axmon A; Jonsson BA; Sennbro CJ; Littorin M; Rannug A
Article: CHEMOSPHERE. 2009;75(5):680-684
Short-term exposure to dioxin impairs bone tissue in male rats
Lind PM; Wejheden C; Lundberg R; Alvarez-Lloret P; Hermsen SAB; Rodriguez-Navarro AB; Larsson S; Rannug A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2009;284(5):2690-2696
The Suggested Physiologic Aryl Hydrocarbon Receptor Activator and Cytochrome P4501 Substrate 6-Formylindolo[3,2-b]carbazole Is Present in Humans
Wincent E; Amini N; Luecke S; Glatt H; Bergman J; Crescenzi C; Rannug A; Rannug U
Article: ENVIRONMENTAL HEALTH. 2008;7:15
Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study
Broberg K; Tinnerberg H; Axmon A; Warholm M; Rannug A; Littorin M
Article: CARCINOGENESIS. 2007;28(9):1902-1905
Evidence of gene-gene interactions in lung carcinogenesis in a large pooled analysis
Vineis P; Anttila S; Benhamou S; Spinola M; Hirvonen A; Kiyohara C; Garte SJ; Puntoni R; Rannug A; Strange RC; Taioli E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2007;104(21):8851-8856
Lightening up the UV response by identification of the arylhydrocarbon receptor as a cytoplasmatic target for ultraviolet B radiation
Fritsche E; Schaefer C; Calles C; Bernsmann T; Bernshausen T; Wurm M; Huebenthal U; Cline JE; Hajimiragha H; Schroeder P; Klotz L-O; Rannug A; Fuerst P; Hanenberg H; Abel J; Krutmann J
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;354(2):396-402
Identification of amino acid residues in the Ah receptor involved in ligand binding
Goryo K; Suzuki A; Del Carpio CA; Siizaki K; Kuriyama E; Mikami Y; Kinoshita K; Yasumoto K-I; Rannug A; Miyamoto A; Fujii-Kuriyama Y; Sogawa K
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2007;16(3):559-565
An international case-control study of glutathione transferase and functionally related polymorphisms and risk of primary adult brain tumors
Schwartzbaum JA; Ahlbom A; Lonn S; Warholm M; Rannug A; Auvinen A; Christensen HC; Henriksson R; Johansen C; Lindholm C; Malmer B; Salminen T; Schoemaker MJ; Swerdlow AJ; Feychting M
Article: TOXICOLOGICAL SCIENCES. 2005;85(2):935-943
Identification of the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole, in cell culture medium, as a factor that controls the background aryl hydrocarbon receptor activity
Öberg M; Bergander L; Håkansson H; Rannug U; Rannug A
Article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2005;580(1-2):53-59
In vitro studies of the influence of glutathione transferases and epoxide hydrolase on the detoxification of acrylamide and glycidamide in blood
Paulsson B; Rannug A; Henderson AP; Golding BT; Törnqvist M; Warholm M
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 2004;149(2-3):151-164
Metabolic fate of the Ah receptor ligand 6-formylindolo[3,2-b]carbazole
Bergander L; Wincent E; Rannug A; Foroozesh M; Alworth W; Rannug U
Article: REGULATORY PEPTIDES. 2004;119(1-2):113-124
Expression of hypothalamic neuropeptides after acute TCDD treatment and distribution of Ah receptor repressor
Fetissov SO; Huang P; Zhang Q; Mimura J; Fujii-Kuriyama Y; Rannug A; Hökfelt T; Ceccatelli S
Article: INTERNATIONAL JOURNAL OF CANCER. 2004;110(2):266-270
Association of metabolic gene polymorphisms with tobacco consumption in healthy controls
Smits KM; Benhamou S; Garte S; Weijenberg MP; Alamanos Y; Ambrosone C; Autrup H; Autrup JL; Baranova H; Bathum L; Boffetta P; Bouchardy C; Brockmoller J; Butkiewicz D; Cascorbi I; Clapper ML; Coutelle C; Daly AK; Muzi G; Dolzan V; Duzhak TG; Farker K; Golka K; Haugen A; Hein DW; Hildesheim A; Hirvonen A; Hsieh LL; Ingelman-Sundberg M; Kalina I; Kang D; Katoh T; Kihara M; Ono-Kihara M; Kim H; Kiyohara C; Kremers P; Lazarus P; Le Marchand L; Lechner MC; London S; Manni JJ; Maugard CM; Morgan GJ; Morita S; Nazar-Stewart V; Kristensen VN; Oda Y; Parl FF; Peters WHM; Rannug A; Rebbeck T; Pinto LFR; Risch A; Romkes M; Salagovic J; Schoket B; Seidegard J; Shields PG; Sim E; Sinnett D; Strange RC; Stucker I; Sugimura H; To-Figueras J; Vineis P; Yu MC; Zheng W; Pedotti P; Taioli E
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2004;13(6):908-914
Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population
Alexandrie AK; Nyberg F; Warholm M; Rannug A
Article: BIOMARKERS. 2004;9(3):298-305
CYP1A1, GSTM1 and GSTT1 polymorphisms and lung cancer: a pooled analysis of gene-gene interactions
Vineis P; Veglia F; Anttila S; Benhamou S; Clapper ML; Dolzan V; Ryberg D; Hirvonen A; Kremers P; Le Marchand L; Pastorelli R; Rannug A; Romkes M; Schoket B; Strange RC; Garte S; Taioli E
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2003;192(3):262-274
TCDD-induced expression of Ah receptor responsive genes in the pituitary and brain of cellular retinol-binding protein (CRBP-I) knockout mice
Huang P; Ceccatelli S; Hoegberg P; Shi TJS; Håkansson H; Rannug A
Article: ENVIRONMENTAL RESEARCH. 2003;93(2):138-148
Constitutive CYP1B1 mRNA expression in human blood mononuclear cells in relation to gender, genotype, and environmental factors
Tuominen R; Warholm M; Möller L; Rannug A
Article: CANCER CAUSES & CONTROL. 2003;14(4):339-346
Pooled analysis of the CYP1A1 exon 7 polymorphism and lung cancer (United States)
Le Marchand LC; Guo CF; Benhamou S; Bouchardy C; Cascorbi I; Clapper ML; Garte S; Haugen A; Ingelman-Sundberg M; Kihara M; Rannug A; Ryberg D; Stücker I; Sugimura H; Taioli E
Article: CARCINOGENESIS. 2003;24(5):875-882
CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers:: a pooled analysis
Hung RJ; Boffetta P; Brockmöller J; Butkiewicz D; Cascorbi I; Clapper ML; Garte S; Haugen A; Hirvonen A; Anttila S; Kalina I; Le Marchand L; London SJ; Rannug A; Romkes M; Salagovic J; Schoket B; Gaspari L; Taioli E
Article: INTERNATIONAL JOURNAL OF CANCER. 2003;104(5):650-657
CYP1A1 T³⁸⁰¹C polymorphism and lung cancer:: A pooled analysis of 2,451 cases and 3,358 controls
Vineis P; Veglia F; Benhamou S; Butkiewicz D; Cascorbi I; Clapper ML; Dolzan V; Haugen A; Hirvonen A; Ingelman-Sundberg M; Kihara M; Kiyohara C; Kremers P; Le Marchand L; Ohshima S; Pastorelli R; Rannug A; Romkes M; Schoket B; Shields P; Strange RC; Stucker I; Sugimura H; Garte S; Gaspart L; Taioli E
Article: INTERNATIONAL JOURNAL OF EPIDEMIOLOGY. 2003;32(1):60-63
Polymorphisms in CYP1A1, GSTM1, GSTT1 and lung cancer below the age of 45 years
Taioli E; Gaspari L; Benhamou S; Boffeta P; Brockmoller J; Butkiewicz D; Cascorbi I; Clapper ML; Dolzan V; Haugen A; Hirvonen A; Husgafvel-Pursiainen K; Kalina I; Kremers P; Le Marchand L; London S; Rannug A; Romkes M; Schoket B; Seidegard J; Strange RC; Stucker I; To-Figueras J; Garte S
Article: DRUG METABOLISM AND DISPOSITION. 2003;31(2):233-241
Characterization of in vitro metabolites of the aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b] carbazole by liquid chromatography-mass spectrometry and NMR.
Bergander L; Wahlström N; Alsberg T; Bergman J; Rannug A; Rannug U
Article: PHARMACOGENETICS AND GENOMICS. 2002;12(8):613-619
Detection and characterization of a novel functional polymorphism in the GSTT1 gene
Alexandrie AK; Rannug A; Juronen E; Tasa G; Warholm M
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2002;11(10):1082-1090
Influence of metabolic genotypes on biomarkers of exposure to 1,3-butadiene in humans
Fustinoni S; Soleo L; Warholm M; Begemann P; Rannug A; Neumann HG; Swenberg JA; Vimercati L; Foà V; Colombi A
Article: CARCINOGENESIS. 2002;23(8):1343-1350
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk
Benhamou S; Lee WJ; Alexandrie AK; Boffetta P; Bouchardy C; Butkiewicz D; Brockmöller J; Clapper ML; Daly A; Dolzan V; Ford J; Gaspari L; Haugen A; Hirvonen A; Husgafvel-Pursiainen K; Ingelman-Sundberg M; Kalina I; Kihara M; Kremers P; Le Marchand L; London SJ; Nazar-Stewart V; Onon-Kihara M; Rannug A; Romkes M; Ryberg D; Seidegard J; Shields P; Strange RC; Stücker I; To-Figueras J; Brennan P; Taioli E
Article: ARCHIVES OF TOXICOLOGY. 2002;76(3):178-186
Susceptibility factors and DNA adducts in peripheral blood mononuclear cells of aluminium smelter workers exposed to polycyclic aromatic hydrocarbons
Tuominen R; Baranczewski P; Warholm M; Hagmar L; Möller L; Rannug A
Article: ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY. 2002;11(2):119-126
A study on diurnal mRNA expression of CYP1A1, AHR, ARNT, and PER2 in rat pituitary and liver
Huang P; Ceccatelli S; Rannug A
Journal article: ENVIRONMENTAL HEALTH PERSPECTIVES. 2002;110(s3):451-489
Cancer Risk Assessment, Indicators, and Guidelines for Polycyclic Aromatic Hydrocarbons in the Ambient Air
Boström C-E; Gerde P; Hanberg A; Jernström B; Johansson C; Kyrklund T; Rannug A; Törnqvist M; Victorin K; Westerholm R
Article: JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY. 2002;12(1):81-91
The effect of relevant genotypes on PAH exposure-related biomarkers.
Kuljukka-Rabb T; Nylund L; Vaaranrinta R; Savela K; Mutanen P; Veidebaum T; Sorsa M; Rannug A; Peltonen K
Journal article: CARCINOGENESIS. 2002;23(10):1771
Meta- and pooled analyses of the effects of glutathione S-transferase M1 polymorphisms and smoking on lung cancer risk (vol 23, pg 1342, 2002)
Benhamou S; Lee WJ; Alexandrie AK; Boffetta P; Bouchardy C; Butkiewicz D; Brockmöller J; Clapper ML; Daly A; Dolzan V; Ford J; Gaspari L; Haugen A; Hirvonen A; Husgafvel-Pursiainen K; Ingelman-Sundberg M; Kalina I; Kihara M; Kremers P; Le Marchand L; London SJ; Nazar-Stewart V; Onon-Kihara M; Rannug A; Romkes M; Ryberg D; Seidegard J; Shields P; Strange RC; Stücker I; To-Figueras J; Brennan P; Taioli E
Article: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION. 2001;10(12):1239-1248
Metabolic gene polymorphism frequencies in control populations
Garte S; Gaspari L; Alexandrie AK; Ambrosone C; Autrup H; Autrup JL; Baranova H; Bathum L; Benhamou S; Boffetta P; Bouchardy C; Breskvar K; Brockmoller J; Cascorbi I; Clapper ML; Coutelle C; Daly A; Dell'Omo M; Dolzan V; Dresler CM; Fryer A; Haugen A; Hein DW; Hildesheim A; Hirvonen A; Hsieh LL; Ingelman-Sundberg M; Kalina I; Kang DH; Kihara M; Kiyohara C; Kremers P; Lazarus P; Le Marchand L; Lechner MC; van Lieshout EMM; London S; Manni JJ; Maugard CM; Morita S; Nazar-Stewart V; Noda K; Oda Y; Parl FF; Pastorelli R; Persson I; Peters WHM; Rannug A; Rebbeck T; Risch A; Roelandt L; Romkes M; Ryberg D; Salagovic J; Schoket B; Seidegard J; Shields PG; Sim E; Sinnet D; Strange RC; Stücker I; Sugimura H; To-Figueras J; Vineis P; Yu MC; Taioli E
Article: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2000;169(2):159-167
Effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the expression of cytochrome P450 1A1, the aryl hydrocarbon receptor, and the aryl hydrocarbon receptor nuclear translocator in rat brain and pituitary
Huang P; Rannug A; Ahlbom E; Håkansson H; Ceccatelli S
Article: ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 2000;383(1):99-107
Regulation of CYP1A1 transcription via the metabolism of the tryptophan-derived 6-formylindolo[3,2-b]carbazole
Wei YD; Bergander L; Rannug U; Rannug A
Article: PHARMACOGENETICS AND GENOMICS. 2000;10(7):645-653
Glutathione transferase T1 phenotype affects the toxicokinetics of inhaled methyl chloride in human volunteers
Löf A; Johanson G; Rannug A; Warholm M
Article: CARCINOGENESIS. 2000;21(4):669-676
CYP1A1 and GSTM1 polymorphisms affect urinary 1-hydroxypyrene levels after PAH exposure
Alexandrie AK; Warholm M; Carstensen U; Axmon A; Hagmar L; Levin JO; Östman C; Rannug A
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2000;269(3):676-680
GSTM1 and mEPHX polymorphisms in Parkinson's disease and age of onset
Ahmadi A; Fredrikson M; Jerregård H; Åkerbäck A; Fall PA; Rannug A; Axelson O; Söderkvist P
Article: SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH. 1999;25(4):351-360
Influence of genetic polymorphisms of biotransformation enzymes on gene mutations, strand breaks of deoxyribonucleic acid, and micronuclei in mononuclear blood cells and urinary 8-hydroxydeoxyguanosine in potroom workers exposed to polyaromatic hydrocarbons
Carstensen U; Hou SM; Alexandrie AK; Högstedt B; Tagesson C; Warholm M; Rannug A; Lambert B; Axmon A; Hagmar L
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1999;118(2):127-140
UV-induced CYP1A1 gene expression in human cells is mediated by tryptophan
Wei YD; Rannug U; Rannug A
Article: JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY. 1999;13(3-4):223-226
Drug metabolizing enzymes in lymphocytes
Raucy JL; Ingelman-Sundberg M; Carpenter S; Rannug A; Rane A; Franklin M; Romkes M
Journal article: TOXICOLOGY LETTERS. 1998;95:187
P3F149 Biomarkers in relation to PAH exposure in aluminum smelter workers
Warholm M; Alexandrie A-K; Carstensen U; Eriksson A; Levin J-O; Östman C; Hagmar L; Rannug A
Article: CHEMICO-BIOLOGICAL INTERACTIONS. 1998;110(1-2):39-55
Rapid and transient induction of CYP1A1 gene expression in human cells by the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole.
Wei YD; Helleberg H; Rannug U; Rannug A
Article: MOLECULAR PHARMACOLOGY. 1997;52(6):958-965
Characterization of a human glutathione S-transferase μ cluster containing a duplicated GSTM1 gene that causes ultrarapid enzyme activity
McLellan RA; Oscarson M; Alexandrie AK; Seidegård J; Evans DAP; Rannug A; Ingelman-Sundberg M
Article: BIOMARKERS. 1997;2(1):57-62
Airway symptoms and lung function in pipe-layers exposed to MDI-based polyurethane pyrolysis products and welding fumes do not relate to host polymorphism for CYP1A1, GSTM1 and NAT2
Jakobsson K; Rannug A; Alexandrie AK; Rylander L; Hagmar L
Article: HUMAN HEREDITY. 1996;46(4):221-225
Association between the p21 codon 31 A1 (arg) allele and lung cancer
Sjalander A; Birgander R; Rannug A; Alexandrie AK; Tornling G; Beckman G
Article: INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH. 1996;68(3):165-169
MDA in plasma as a biomarker of exposure to pyrolysed MDI-based polyurethane: correlations with estimated cumulative dose and genotype for N-acetylation.
Dalene M; Jakobsson K; Rannug A; Skarping G; Hagmar L
Article: CHEMISTRY AND BIOLOGY. 1995;2(12):841-845
Structure elucidation of two tryptophan-derived, high affinity Ah receptor ligands.
Rannug U; Rannug A; Sjöberg U; Li H; Westerholm R; Bergman J
Article: CARCINOGENESIS. 1995;16(9):2233-2236
P53 POLYMORPHISMS AND HAPLOTYPES IN LUNG-CANCER
BIRGANDER R; SJALANDER A; RANNUG A; ALEXANDRIE AK; SUNDBERG MI; SEIDEGARD J; TORNLING G; BECKMAN G; BECKMAN L
Journal article: EPIDEMIOLOGY. 1995;6(2):s47
242 POLYMORPHIC SOLVENT METABOLISM IN SWEDISH POPULATIONS
Högberg J; Alexandrie AK; Sigvardsson K; Warholm M; Rannug A
Article: RADIO SCIENCE. 1995;30(1):223-231
MAGNETIC-FIELDS AND CANCER DEVELOPMENT IN ANIMAL-MODELS
HOLMBERG B; RANNUG A
Journal article: OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 1994;51(12):812-816
GENETIC-POLYMORPHISM FOR GLUTATHIONE-S-TRANSFERASE-MU IN ASBESTOS-CEMENT WORKERS
JAKOBSSON K; RANNUG A; ALEXANDRIE AK; RYLANDER L; ALBIN M; HAGMAR L
Journal article: PHARMACOGENETICS AND GENOMICS. 1994;4(6):307-312
Polymorphic distribution of glutathione transferase activity with methyl chloride in human blood.
Warholm M; Alexandrie AK; Högberg J; Sigvardsson K; Rannug A
Journal article: CARCINOGENESIS. 1994;15(9):1785-1790
GENETIC SUSCEPTIBILITY TO LUNG-CANCER WITH SPECIAL EMPHASIS ON CYP1A1 AND GSTM1 - A STUDY ON HOST FACTORS IN RELATION TO AGE AT ONSET, GENDER AND HISTOLOGICAL CANCER TYPES
ALEXANDRIE AK; SUNDBERG MI; SEIDEGARD J; TORNLING G; RANNUG A
Journal article: CARCINOGENESIS. 1994;15(7):1347-1352
AROMATIC DNA-ADDUCTS, MICRONUCLEI AND GENETIC-POLYMORPHISM FOR CYO1A1 AND GST1 IN CHIMNEY SWEEPS
ICHIBA M; HAGMAR L; RANNUG A; HOGSTEDT B; ALEXANDRIE AK; CARSTENSEN U; HEMMINKI K
Journal article: CARCINOGENESIS. 1994;15(2):153-157
Intermittent 50 Hz magnetic field and skin tumor promotion in SENCAR mice.
Rannug A; Holmberg B; Ekström T; Mild KH; Gimenez-Conti I; Slaga TJ
Journal article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1993;289(2):187-195
B- and T-lymphocyte micronuclei in chimney sweeps with respect to genetic polymorphism for CYP1A1 and GST1 (class Mu).
Carstensen U; Alexandrie AK; Högstedt B; Rannug A; Bratt I; Hagmar L
Journal article: ENVIRONMENTAL RESEARCH. 1993;62(2):223-229
A rat liver foci promotion study with 50-Hz magnetic fields.
Rannug A; Holmberg B; Mild KH
Journal article: CARCINOGENESIS. 1993;14(4):573-578
A study on skin tumour formation in mice with 50 Hz magnetic field exposure.
Rannug A; Ekström T; Mild KH; Holmberg B; Gimenez-Conti I; Slaga TJ
Journal article: FEBS LETTERS. 1993;319(3):207-211
GENETIC-POLYMORPHISM OF CYTOCHROME-P4502E1 IN A SWEDISH POPULATION - RELATIONSHIP TO INCIDENCE OF LUNG-CANCER
PERSSON I; JOHANSSON I; BERGLING H; DAHL ML; SEIDEGARD J; RYLANDER R; RANNUG A; HOGBERG J; SUNDBERG MI
Journal article: BIOELECTROMAGNETICS. 1993;14(1):17-27
Rat liver foci study on coexposure with 50 Hz magnetic fields and known carcinogens.
Rannug A; Holmberg B; Ekström T; Mild KH
Journal article: ENVIRONMENTAL AND MOLECULAR MUTAGENESIS. 1992;20(4):289-296
Certain tryptophan photoproducts are inhibitors of cytochrome P450-dependent mutagenicity.
Rannug U; Agurell E; Rannug A; Cederberg H
Journal article: CARCINOGENESIS. 1991;12(11):2007-2015
USE OF ARTIFICIAL-INTELLIGENCE IN STRUCTURE AFFINITY CORRELATIONS OF 2,3,7,8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) RECEPTOR LIGANDS
RANNUG U; SJOGREN M; RANNUG A; GILLNER M; TOFTGARD R; GUSTAFSSON JA; ROSENKRANZ H; KLOPMAN G
Journal article: SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH. 1991;17(2):123-132
ASSESSMENT OF GENOTOXIC EXPOSURE IN SWEDISH COKE-OVEN WORK BY DIFFERENT METHODS OF BIOLOGICAL MONITORING
REUTERWALL C; ARINGER L; ELINDER CG; RANNUG A; LEVIN JO; JURINGE L; ONFELT A
Journal article: CARCINOGENESIS. 1989;10(3):593-599
The role of GSH depletion and toxicity in hydroquinone-induced development of enzyme-altered foci.
Stenius U; Warholm M; Rannug A; Walles S; Lundberg I; Högberg J
Journal article: CHEMOSPHERE. 1989;18(1-6):1101-1106
UV-irradiation of tryptophan gives rise to AHH-inducing compounds with very high affinity for the Ah receptor
Rannug A; Rannug U
Journal article: TOXICOLOGY LETTERS. 1988;42(2):131-136
Ah receptor ligands in tobacco smoke.
Löfroth G; Rannug A
Journal article: IARC (INTERNATIONAL AGENCY FOR RESEARCH ON CANCER) SCIENTIFIC PUBLICATIONS. 1988;(89):396-400
An improved standardized procedure for urine mutagenicity testing.
Rannug A; Olsson M; Aringer L; Brunius G
Journal article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1984;141(3-4):145-147
Protection from toxic and mutagenic effects of H2O2 by catalase induction in Salmonella typhimurium.
Winquist L; Rannug U; Rannug A; Ramel C
Journal article: MUTATION RESEARCH - ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS INCLUDING METHODOLOGY. 1984;130(3):232
Chloroderivatives of polynuclear aromatic hydrocarbons, a new type of potent bacterial mutagens
Rannug U; Rannug A; Colmsjö C; Ramel C
Journal article: MUTATION RESEARCH - ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS INCLUDING METHODOLOGY. 1984;130(3):188
A new mechanism for mutagens/carcinogens
Rannug A; Rannug U; Ramel C
Journal article: CHEMICO-BIOLOGICAL INTERACTIONS. 1984;49(3):329-340
Enzyme inhibition as a possible mechanism of the mutagenicity of dithiocarbamic acid derivatives in Salmonella typhimurium.
Rannug A; Rannug U
Journal article: PROGRESS IN CLINICAL AND BIOLOGICAL RESEARCH. 1984;141:407-419
Genotoxic effects of additives in synthetic elastomers with special consideration to the mechanism of action of thiurams and dithiocarbamates.
Rannug A; Rannug U; Ramel C
Journal article: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 1984;135(1):21-29
Some chloro derivatives of polynuclear aromatic hydrocarbons are potent mutagens in Salmonella typhimurium.
Colmsjö A; Rannug A; Rannug U
Journal article: MUTATION RESEARCH - ENVIRONMENTAL MUTAGENESIS AND RELATED SUBJECTS INCLUDING METHODOLOGY. 1983;113(3-4):296
Data from mutagenicity tests on process vapours from the rubber industry
Rannug A; Rannug U
Journal article: SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH. 1983;9 Suppl 2:27-37
Mutagenicity of rubber additives and curing fumes. Results from five short-term bioassays.
Donner M; Husgafvel-Pursiainen K; Jenssen D; Rannug A
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Review: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2020;21(16):E5681-5681
How the AHR Became Important in Intestinal Homeostasis-A Diurnal FICZ/AHR/CYP1A1 Feedback Controls Both Immunity and Immunopathology
Rannug A
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S117-S118
Ketoconazole activates the AHR by inhibiting CYP1A1 dependent metabolism of FICZ
Bengtsson J; Wincent E; Rannug A; Rannug U
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S14
Biological effects of the proposed endogenous AHR ligand FICZ
Rannug A; Wincent E; Bardbori AM; Rannug U
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S14
Formation and background levels of the endogenous AHR ligand FICZ in vitro and in vivo
Rannug U; Smirnova A; Alsberg T; Wincent E; Rannug A
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S117
Cytochrome P4501 inhibition as a novel mechanism for activation of the Ah receptor
Wincent E; Bengtsson J; Bardbori AM; Alsberg T; Rannug U; Rannug A
Meeting abstract: TOXICOLOGY LETTERS. 2012;211:S143-S144
Metals induce cytochrome P4501A1 through inhibition of metabolic degradation of FICZ
Bardbori AM; Wincent E; Rannug U; Rannug A
Editorial comment: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(43):18239-18240
The tryptophan photoproduct 6-formylindolo[3,2-b]carbazole helps genes jump
Rannug A
Review: TRENDS IN IMMUNOLOGY. 2009;30(9):447-454
The aryl hydrocarbon receptor in immunity
Esser C; Rannug A; Stockinger B
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2008;128:S220
Involvement of arylhydrocarbon receptor (AhR-)signaling in skin melanogenesis
Krutmann I; Lux B; Luecke S; Fritsche E; Abel J; Esser C; Rannug A
Conference publication: DRUG METABOLISM REVIEWS. 2007;39:359
IS THE SUGGESTED ENDOGENOUS AH RECEPTOR LIGAND, 6-FORMYLINDOLO[3,2-B]CARBAZOLE, THE IDEAL SUBSTRATE FOR HUMAN SULT1 AND CYP1 ENZYMES?
Wincent EE; Rannug A; Rannug U
Review: AMERICAN JOURNAL OF EPIDEMIOLOGY. 2006;164(11):1027-1042
Meta- and pooled analysis of GSTT1 and lung cancer:: A HuGE-GSEC review
Raimondi S; Paracchini V; Autrup H; Barros-Dios JM; Benhamou S; Boffetta P; Cote ML; Dialyna IA; Dolzan V; Filiberti R; Garte S; Hirvonen A; Husgafvel-Pursiainen K; Imyanitov EN; Kalina I; Kang D; Kiyohara C; Kohno T; Kremers P; Lan Q; London S; Povey AC; Rannug A; Reszka E; Risch A; Romkes M; Schneider J; Seow A; Shields PG; Sobti RC; Sorensen M; Spinola M; Spitz MR; Strange RC; Stucker I; Sugimura H; To-Figueras J; Tokudome S; Yang P; Yuan J-M; Warholm M; Taioli E
Meeting abstract: TOXICOLOGY LETTERS. 2006;164:S31
A possible role for the AhR in regulating stress hormones and pigmentation
Rannug A
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2006;126:138
Lightening up the UV response: the arylhydrocarbon receptor is a cytoplasmic photosensor
Fritsche E; Schaefer C; Bernsmann T; Calles C; Wurm M; Huebenthal U; Cline JE; Schroeder P; Rannug A; Klotz L; Fuerst P; Hanenberg H; Abel J; Krutmann J
Review: BIOLOGICAL CHEMISTRY. 2006;387(9):1149-1157
The aryl hydrocarbon receptor and light
Rannug A; Fritsche E
Published conference paper: MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS. 2005;592(1-2):45-57
Metabolic gene polymorphisms and lung cancer risk in non-smokers - An update of the GSEC study
Raimondi S; Boffetta P; Anttila S; Bröckmoller J; Butkiewicz D; Cascorbi I; Clapper ML; Dragani TA; Garte S; Gsur A; Haidinger G; Hirvonen A; Ingelman-Sundberg M; Kalina I; Lan Q; Leoni VP; Le Marchand L; London SJ; Neri M; Povey AC; Rannug A; Reszka E; Ryberg D; Risch A; Romkes M; Ruano-Ravina A; Schoket B; Spinola M; Sugimura H; Wu XF; Taioli E
Published conference paper: CELL BIOLOGY AND TRANSLATIONAL MEDICINE, VOL 14: STEM CELLS IN LINEAGE SPECIFIC DIFFERENTIATION AND DISEASE. 2005;561:127-133
In vitro studies of the influence of certain enzymes on the detoxification of acrylamide and glycidamide in blood
Paulsson B; Warholm M; Rannug A; Törnqvist M
Conference publication: ACS NATIONAL MEETING BOOK OF ABSTRACTS. 2004;227:U40
In vitro studies of the effect of detoxifying enzymes on the relationship between exposure and dose of acrylamide or glycidamide in blood.
Paulsson BE; Warholm M; Rannug A; Törnqvist M
Conference publication: TOXICOLOGY AND APPLIED PHARMACOLOGY. 2004;197(3):216
Identification of factors that controls the CYP1A1 background activity in vitro
Öberg M; Bergander L; Häkansson H; Rannug U; Rannug A
Conference publication: TOXICOLOGICAL SCIENCES. 2003;72:369
Metabolic degradation of a suggested endogenous arylhydrocarbon receptor ligand, the tryptophan photoproduct 6-formylindolo[3,2-b]carbazole.
Rannug A; Bergander L; Alworth W; Rannug U
Conference publication: TOXICOLOGICAL SCIENCES. 2003;72:98
Influence of metabolic genotypes on chromosome aberrations in butadiene exposed workers.
Warholm M; Rannug A; Fustinoni S; Begemann P; Soleo L; Barale R; Järventaus H; Norppa H
Conference publication: TOXICOLOGICAL SCIENCES. 2003;72:319
Reliability of chlorzoxazone as an in vivo probe of CYP2E1 activity in humans.
Ernstgård L; Rannug A; Warholm M; Johanson G
Published conference paper: NEUROTOXICOLOGY. 2002;23(6):783-793
Constitutive and TCDD-induced expression of Ah receptor-responsive genes in the pituitary
Huang P; Ceccatelli S; Håkansson H; Grandison L; Rannug A
Review: ENVIRONMENTAL HEALTH PERSPECTIVES. 2002;110(Suppl 3):451-488
Cancer risk assessment, indicators, and guidelines for polycyclic aromatic hydrocarbons in the ambient air
Boström CE; Gerde P; Hanberg A; Jernström B; Johansson C; Kyrklund T; Rannug A; Törnqvist M; Victorin K; Westerholm R
Review: BIOMARKERS. 2002;7(3):230-241
Microsomal epoxide hydrolase polymorphisms and lung cancer risk: a quantitative review
Lee WJ; Brennan P; Boffetta P; London SJ; Benhamou S; Rannug A; To-Figueras J; Ingelman-Sundberg M; Shields P; Gaspari L; Taioli E
Conference publication: TOXICOLOGY. 2001;164(1-3):145
The role of cytochrome P4501A1 in the regulation of cell growth
Wei YD; Rannug U; Rannug A
Published conference paper: CHEMICO-BIOLOGICAL INTERACTIONS. 2001;133(1-3):102-105
Determination of interindividual variation in glutathione transferase P1 mRNA expression and enzyme activity in human peripheral blood cells
Warholm M; Karlsson Å; Tuominen R; Rannug A
Other: PHARMACOGENETICS AND GENOMICS. 1995;5(4):252-254
Genotypic and phenotypic determination of polymorphic glutathione transferase T1 in a Swedish population.
Warholm M; Rane A; Alexandrie AK; Monaghan G; Rannug A
Published conference paper: TOXICOLOGY LETTERS. 1995;77(1-3):363-369
Radiographic changes and lung function in relation to activity of the glutathione transferases theta and mu among asbestos cement workers.
Jakobsson K; Rannug A; Alexandrie AK; Warholm M; Rylander L; Hagmar L
Review: JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE. 1995;37(1):25-36
GENETIC-POLYMORPHISM OF CYTOCHROMES P450 1A1, 2D6 AND 2E1 - REGULATION AND TOXICOLOGICAL SIGNIFICANCE
RANNUG A; ALEXANDRIE AK; PERSSON I; INGELMANSUNDBERG M
Book chapter: SHORT-TERM BIOASSAYS IN THE ANALYSIS OF COMPLEX ENVIRONMENTAL MIXTURES III: ENVIRONMENTAL SCIENCE RESEARCH. 1983;p. 541-553
Application of Mutagenicity Tests for Detection and Source Assessment of Genotoxic Agents in the Rubber Work Atmosphere
Rannug AH; Östman C
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Forskningsbidrag

Critical physiological functions of the endogenous aryl hydrocarbon receptor ligand 6-formylindolo[3,2-b]carbazole are disturbed by environmental pollutants.
Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
1 January 2012 - 31 December 2014
A physiological role of the aryl hydrocarbon receptor in skin
Swedish Research Council for Environment Agricultural Sciences and Spatial Planning
1 January 2008 - 31 December 2010

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Professor Emeritus/Emerita, Institutet för miljömedicin, Karolinska Institutet, 2021-2024

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Docent, Inriktning: toxikologi, Karolinska Institutet, 2006

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