Rongrong Fan
Senior Forskare
| Docent
E-postadress: rongrong.fan@ki.se
Besöksadress: Blickagången 16, 14152 Flemingsberg
Postadress: H2 Biovetenskaper och näringslära, H2 BioNut Fan, 171 77 Stockholm
Om mig
- Lab page:
https://ki.se/en/bionut/liver-and-monocyte-remodelling-in-non-alcoholic-fatty-liver-disease-and-cardiovascular
Research grants:
The Rolf Luft Grant for Instrumentation 2022
SRP diabetes 2022
KI faculty-funded senior researcher 2021
EFSD / Novo Nordisk Future Leaders Award 2021
Cancerfonden
Swedish research council (Vetenskapsrådet)
CIMED
NOVO NORDISK Foundation
KI Doctoral funding
Åke Wibergs Stiftelse
Diabetes Wellness Sverige Foundation
EFSD / Lilly research fellowship
KI foundation
Commission of trust:
Editorial board: Frontiers in Endocrinology 2021-.
Guest editor: Frontiers in Endocrinology 2020-2021.
Steering Committee: lipoprotein research networks in KI south campus
(supported by CIMED).
Grant evaluation task for: French National Research Agency (ANR)
Grant review panel: Cancerfonden, KID
Invited reviewer in: Nat Com, JCI, eLife, JBC, FASEB J, Diabetologia, etc.
Poster assesment committee: Epigenomics, nuclear receptor and diseases summer school. Spetses, 2019.
Poster assesment committee: 7th Endometrial SRP Diabetes Joint Retreat. Stockholm, 2017.
Poster assesment committee: Epigenomics, nuclear receptor and diseases summer school. Spetses, 2017.
Forskningsbeskrivning
- My research combines the phenotypic/clinical analysis with multi-OMICs approaches to understand the fundamental question of how over-nutritional
signals alter chromatin remodelling to promote metabolic disease development. We have so far analyzed different patient samples in the transcriptomic, cistromic and epigenomic levels and identified a group of interesting candidates involved in species-conserved and disease-relevant regulation of glucose and lipid metabolism. Of particular interest is the transcription factor coregulator GPS2, the dysregulation of which is associated with de-repressed inflammation and impaired lipid oxidation pathways, leading to type 2 diabetes and liver disease progression.
The ongoing research activity involves further investigation of the coregulator-based mechanisms in the genomic and epigenomic level in various
disease contexts. Understanding such pathways is crucial for better deciphering disease mechanisms which is ultimately required for identifying
novel targets with diagnostic and intervention potential.
Undervisning
- Main supervisor of 2 ongoing PhD student
Cosupervisor of 1 ongoing PhD student and 2 completed PhD students
Project supervisor of 5 bachelor students and 2 Master student
Evaluation of 4 Master theses
Half-time committee of 5 PhD students
Mentor of 2 PhD students
More than 200 teaching hours in Bachelor, Master and PhD courses
Professional university pedagogy training (equivalent to more than 5 weeks)
Artiklar
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Article: SCIENCE ADVANCES. 2024;10(1):eadi2689
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Article: NUCLEIC ACIDS RESEARCH. 2023;51(3):1067-1086
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Article: NATURE COMMUNICATIONS. 2023;14(1):224
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Article: BIOMATERIALS RESEARCH. 2022;26(1):64
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Article: EUROPEAN JOURNAL OF EPIDEMIOLOGY. 2022;37(7):723-733
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Article: STAR PROTOCOLS. 2022;3(2):101338
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Article: CELL COMMUNICATION AND SIGNALING. 2022;20(1):45
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Article: MOLECULAR CELL. 2021;81(5):953-968.e9
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Article: ENVIRONMENTAL TOXICOLOGY. 2020;35(11):1170-1178
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Article: CARDIOVASCULAR DIABETOLOGY. 2020;19(1):182
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Article: CELL BIOLOGY INTERNATIONAL. 2019;43(8):940-953
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Article: NATURE COMMUNICATIONS. 2019;10(1):1684
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Article: DIABETOLOGY & METABOLIC SYNDROME. 2019;11:94
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Article: METHODS IN MOLECULAR BIOLOGY. 2019;1951:167-178
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Article: CELL REPORTS. 2018;24(11):2957-2971.e6
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Article: ONCOGENE. 2018;37(19):2586-2600
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Article: ANTIOXIDANTS & REDOX SIGNALING. 2017;27(13):962-976
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Article: NATURE MEDICINE. 2016;22(7):780-791
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Article: DIABETOLOGIA. 2013;56(2):423-433
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Article: JOURNAL OF CLINICAL INVESTIGATION. 2013;123(1):362-379
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Article: CELL TRANSPLANTATION. 2013;22(1):147-158
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Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2011;43(4):525-534
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Article: DIABETES OBESITY & METABOLISM. 2010;12(9):815-824
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Article: AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY. 2010;298(2):F391-F400
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Article: INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2009;41(7):1526-1535
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Article: KIDNEY INTERNATIONAL. 2008;74(4):467-477
- Visa fler
Alla övriga publikationer
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Editorial comment: FRONTIERS IN ENDOCRINOLOGY. 2021;12:828635
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Review: FASEB JOURNAL. 2020;34(7):8796-8809
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Review: FRONTIERS IN ENDOCRINOLOGY. 2019;10:411
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Review: FEBS LETTERS. 2017;591(19):2959-2977
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Review: HANDBOOK OF EXPERIMENTAL PHARMACOLOGY. 2016;233:95-135
Forskningsbidrag
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Swedish Research Council1 January 2024 - 31 December 2026
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Swedish Research Council1 January 2020 - 31 December 2023
Anställningar
- Senior Forskare, Biovetenskaper och näringslära, Karolinska Institutet, 2022-2024
Examina och utbildning
- Docent, Cell- och molekylärbiologi, Karolinska Institutet, 2022