Petter Brodin

Om mig
Publikationer
Forskningsbidrag
CV
Populärvetenskap och samverkan

Om mig

Petter Brodin är född i Stockholm 1982. Han tog läkarexamen samt disputerade vid KI 2011. Efter postdoc 2012–2013 vid HHMI, Stanford University, Palo Alto, USA, återvände han till KI och SciLifeLab där han etablerade en första nationell infrastruktur för masscytometri, som han lett fram till 2023. Brodin blev docent 2018 och avdelningschef för klinisk pediatrik 2019-2024.

Som specialistläkare är han verksam vid Astrid Lindgrens barnsjukhus, barnreumatologiska kliniken, Karolinska Universitetssjukhuset sedan 2019. Brodins forskning har tilldelats ett flertal priser, bland annat KVA:s Göran Gustavsson Award 2020, Olle Söders pris, 2023, Oskar Medins pris, 2023. Han är invald fellow i Henry Kunckels samfund för humanimmunologi, EMBO young investigator sedan 2019, ledamot i Sverige unga akademi, 2019-2024.

Petter Brodin har anställts som professor i pediatrisk immunologi vid Karolinska Institutet från 1 juli 2021

Artiklar

Article: NATURE METHODS. 2024;21(6):1044-1052

Molecular pixelation: spatial proteomics of single cells by sequencing.

Karlsson F; Kallas T; Thiagarajan D; Karlsson M; Schweitzer M; Navarro JF; Leijonancker L; Geny S; Pettersson E; Rhomberg-Kauert J; Larsson L; van Ooijen H; Petkov S; González-Granillo M; Bunz J; Dahlberg J; Simonetti M; Sathe P; Brodin P; Barrio AM; Fredriksson S
Journal article: BIORXIV. 2024;:2024.04.16.589585

Antibody-mediated cellular responses are dysregulated in Multisystem Inflammatory Syndrome in Children (MIS-C).

Dick JK; Sangala JA; Krishna VD; Khaimraj A; Hamel L; Erickson SM; Hicks D; Soigner Y; Covill LE; Johnson A; Ehrhardt MJ; Ernste K; Brodin P; Koup RA; Khaitan A; Baehr C; Thielen BK; Henzler CM; Skipper C; Miller JS; Bryceson YT; Wu J; John CC; Panoskaltsis-Mortari A; Orioles A; Steiner ME; Cheeran MC-J; Pravetoni M; Hart GT
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2024;99(4)

Gut bacteria at 6 months of age are associated with immune cell status in 1-year-old children

Nilsen M; Nygaard UC; Brodin P; Carlsen KCL; Fredheim C; Haugen G; Hedlin G; Jonassen CM; Jonsmoen ULA; Lakshmikanth T; Nordlund B; Olin A; Rehbinder EM; Skjerven HO; Snipen L; Staff AC; Soederhaell C; Vettukattil R; Rudi K
Journal article: CANCER RESEARCH. 2024;84(6_Supplement):6378

Abstract 6378: Systems-level immunomonitoring in children with solid tumors

Chen Q; Zhao B; Tan Z; Hedberg G; Wang J; Gonzalez L; Mugabo C; Johnsson A; Páez L; Rodriguez L; James A; Chen Y; Mikes J; Barcenilla H; Wang C; Davis MM; Carlson L-M; Pal N; Herold N; Blomgren K; Repsilber D; Lakshmikanth T; Kogner P; Ljungblad L; Brodin P
Article: NATURE. 2024;626(8000):827-835

Smoking changes adaptive immunity with persistent effects.

Saint-André V; Charbit B; Biton A; Rouilly V; Possémé C; Bertrand A; Rotival M; Bergstedt J; Patin E; Albert ML; Quintana-Murci L; Duffy D; Milieu Intérieur Consortium
Article: NPJ VACCINES. 2024;9(1):42

No link between type I interferon autoantibody positivity and adverse reactions to COVID-19 vaccines.

Yalcinkaya A; Cavalli M; Cederholm A; Aranda-Guillén M; Behere A; Mildner H; Lakshmikanth T; Gonzalez L; Mugabo CH; Johnsson A; Ekwall O; Kämpe O; Bensing S; Brodin P; Hallberg P; Wadelius M; Landegren N
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2024;221(2):e20231353

Higher COVID-19 pneumonia risk associated with anti-IFN-α than with anti-IFN-ω auto-Abs in children.

Bastard P; Gervais A; Taniguchi M; Saare L; Särekannu K; Le Voyer T; Philippot Q; Rosain J; Bizien L; Asano T; Garcia-Prat M; Parra-Martínez A; Migaud M; Tsumura M; Conti F; Belot A; Rivière JG; Morio T; Tanaka J; Javouhey E; Haerynck F; Duvlis S; Ozcelik T; Keles S; Tandjaoui-Lambiotte Y; Escoda S; Husain M; Pan-Hammarström Q; Hammarström L; Ahlijah G; Abi Haidar A; Soudee C; Arseguel V; Abolhassani H; Sahanic S; Tancevski I; Nukui Y; Hayakawa S; Chrousos GP; Michos A; Tatsi E-B; Filippatos F; Rodriguez-Palmero A; Troya J; Tipu I; Meyts I; Roussel L; Ostrowski SR; Schidlowski L; Prando C; Condino-Neto A; Cheikh N; Bousfiha AA; El Bakkouri J; COVID Clin; GEN-COVID Study Group; COVID Human Genetic ; Peterson P; Pujol A; Lévy R; Quartier P; Vinh DC; Boisson B; Béziat V; Zhang S-Y; Borghesi A; Pession A; Andreakos E; Marr N; Mentis A-FA; Mogensen TH; Rodríguez-Gallego C; Soler-Palacin P; Colobran R; Tillmann V; Neven B; Trouillet-Assant S; Brodin P; Abel L; Jouanguy E; Zhang Q; Martinón-Torres F; Salas A; Gómez-Carballa A; Gonzalez-Granado LI; Kisand K; Okada S; Puel A; Cobat A; Casanova J-L
Article: CYTOMETRY PART B-CLINICAL CYTOMETRY. 2024;105(2):124-138

Standardized high-dimensional spectral cytometry protocol and panels for whole blood immune phenotyping in clinical and translational studies.

Dott T; Culina S; Chemali R; Mansour CA; Dubois F; Jagla B; Doisne JM; Rogge L; Huetz F; Jönsson F; Commere P-H; Di Santo J; Terrier B; Quintana-Murci L; Duffy D; Hasan M; Milieu Intérieur Consortium
Article: PEDIATRIC RESEARCH. 2024;95(3):762-769

Antisecretory factor in breastmilk is associated with reduced incidence of sepsis in preterm infants.

Gustafsson A; Johansson E; Henckel E; Olin A; Rodriguez L; Brodin P; Lange S; Bohlin K
Article: SCIENCE. 2024;383(6680):eadg7942

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid.

Cervia-Hasler C; Brüningk SC; Hoch T; Fan B; Muzio G; Thompson RC; Ceglarek L; Meledin R; Westermann P; Emmenegger M; Taeschler P; Zurbuchen Y; Pons M; Menges D; Ballouz T; Cervia-Hasler S; Adamo S; Merad M; Charney AW; Puhan M; Brodin P; Nilsson J; Aguzzi A; Raeber ME; Messner CB; Beckmann ND; Borgwardt K; Boyman O
Article: SCIENCE IMMUNOLOGY. 2023;8(90):eabp8966

Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs.

Bastard P; Vazquez SE; Liu J; Laurie MT; Wang CY; Gervais A; Le Voyer T; Bizien L; Zamecnik C; Philippot Q; Rosain J; Catherinot E; Willmore A; Mitchell AM; Bair R; Garçon P; Kenney H; Fekkar A; Salagianni M; Poulakou G; Siouti E; Sahanic S; Tancevski I; Weiss G; Nagl L; Manry J; Duvlis S; Arroyo-Sánchez D; Paz Artal E; Rubio L; Perani C; Bezzi M; Sottini A; Quaresima V; Roussel L; Vinh DC; Reyes LF; Garzaro M; Hatipoglu N; Boutboul D; Tandjaoui-Lambiotte Y; Borghesi A; Aliberti A; Cassaniti I; Venet F; Monneret G; Halwani R; Sharif-Askari NS; Danielson J; Burrel S; Morbieu C; Stepanovskyy Y; Bondarenko A; Volokha A; Boyarchuk O; Gagro A; Neuville M; Neven B; Keles S; Hernu R; Bal A; Novelli A; Novelli G; Saker K; Ailioaie O; Antolí A; Jeziorski E; Rocamora-Blanch G; Teixeira C; Delaunay C; Lhuillier M; Le Turnier P; Zhang Y; Mahevas M; Pan-Hammarström Q; Abolhassani H; Bompoil T; Dorgham K; COVID HGE Consortium; French COVID Study Group; COMET Consortium; Gorochov G; Laouenan C; Rodríguez-Gallego C; Ng LFP; Renia L; Pujol A; Belot A; Raffi F; Allende LM; Martinez-Picado J; Ozcelik T; Imberti L; Notarangelo LD; Troya J; Solanich X; Zhang S-Y; Puel A; Wilson MR; Trouillet-Assant S; Abel L; Jouanguy E; Ye CJ; Cobat A; Thompson LM; Andreakos E; Zhang Q; Anderson MS; Casanova J-L; DeRisi JL
Article: GUT MICROBES. 2023;15(2):2287618

Unveiling Candida albicans intestinal carriage in healthy volunteers: the role of micro- and mycobiota, diet, host genetics and immune response.

Delavy M; Sertour N; Patin E; Le Chatelier E; Cole N; Dubois F; Xie Z; Saint-André V; Manichanh C; Walker AW; Quintana-Murci L; Duffy D; d'Enfert C; Bougnoux M-E; Consortium MI
Article: NATURE. 2023;623(7988):803-813

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency.

Le Voyer T; Parent AV; Liu X; Cederholm A; Gervais A; Rosain J; Nguyen T; Perez Lorenzo M; Rackaityte E; Rinchai D; Zhang P; Bizien L; Hancioglu G; Ghillani-Dalbin P; Charuel J-L; Philippot Q; Gueye MS; Maglorius Renkilaraj MRL; Ogishi M; Soudée C; Migaud M; Rozenberg F; Momenilandi M; Riller Q; Imberti L; Delmonte OM; Müller G; Keller B; Orrego J; Franco Gallego WA; Rubin T; Emiroglu M; Parvaneh N; Eriksson D; Aranda-Guillen M; Berrios DI; Vong L; Katelaris CH; Mustillo P; Raedler J; Bohlen J; Bengi Celik J; Astudillo C; Winter S; NF-κB Consortium; COVID Human Genetic Effort; McLean C; Guffroy A; DeRisi JL; Yu D; Miller C; Feng Y; Guichard A; Béziat V; Bustamante J; Pan-Hammarström Q; Zhang Y; Rosen LB; Holland SM; Bosticardo M; Kenney H; Castagnoli R; Slade CA; Boztuğ K; Mahlaoui N; Latour S; Abraham RS; Lougaris V; Hauck F; Sediva A; Atschekzei F; Sogkas G; Poli MC; Slatter MA; Palterer B; Keller MD; Pinzon-Charry A; Sullivan A; Droney L; Suan D; Wong M; Kane A; Hu H; Ma C; Grombiříková H; Ciznar P; Dalal I; Aladjidi N; Hie M; Lazaro E; Franco J; Keles S; Malphettes M; Pasquet M; Maccari ME; Meinhardt A; Ikinciogullari A; Shahrooei M; Celmeli F; Frosk P; Goodnow CC; Gray PE; Belot A; Kuehn HS; Rosenzweig SD; Miyara M; Licciardi F; Servettaz A; Barlogis V; Le Guenno G; Herrmann V-M; Kuijpers T; Ducoux G; Sarrot-Reynauld F; Schuetz C; Cunningham-Rundles C; Rieux-Laucat F; Tangye SG; Sobacchi C; Doffinger R; Warnatz K; Grimbacher B; Fieschi C; Berteloot L; Bryant VL; Trouillet Assant S; Su H; Neven B; Abel L; Zhang Q; Boisson B; Cobat A; Jouanguy E; Kampe O; Bastard P; Roifman CM; Landegren N; Notarangelo LD; Anderson MS; Casanova J-L; Puel A
Journal article: CIRCULATION. 2023;148:a16646

Evidence of Protein Dysregulation in Patients With Post-Acute COVID-19 Syndrome With- and Without Postural Orthostatic Tachycardia Syndrome

Zhao A; Mahdi A; Fredengren E; Fedorowski A; Braunschweig F; Brodin P; Nygren-Bonnier M; Runold M; Bruchfeld J
Journal article: JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2023;159:104065

Immune system adaptation during gender-affirming testosterone treatment

Consiglio C; Tadepally L; Sardh F; Forlin R; Wang J; Tan Z; Barcenilla H; Rodriguez L; Sugrue J; Noori P; Paez LP; Gonzalez L; Mugabo CH; Johnsson A; Hallgren A; Pou C; Chen Y; Mikes J; James A; Dahlqvist P; Wahlberg J; Hagelin A; Holmberg M; Degerblad M; Isaksson M; Duffy D; Kampe O; Landegren N; Brodin P
Article: ISCIENCE. 2023;26(8):107422

Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks.

Villain E; Chanson A; Mainka M; Kampschulte N; Le Faouder P; Bertrand-Michel J; Brandolini-Bulon M; Charbit B; Musvosvi M; Bilek N; Scriba TJ; Quintana-Murci L; Schebb NH; Duffy D; Gladine C; Milieu Interieur Consortium
Article: IMMUNITY. 2023;56(6):1255-1268.e5

Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens.

Bee GCW; Lokken-Toyli KL; Yeung ST; Rodriguez L; Zangari T; Anderson EE; Ghosh S; Rothlin CV; Brodin P; Khanna KM; Weiser JN
Journal article: JOURNAL OF CLINICAL ONCOLOGY. 2023;41(16_suppl):3110

First-in-human (FIH) phase I dose escalation study (part A) of the first oral allosteric modulator of phosphoinositide 3-kinase inhibitor delta (PI3Kδ) roginolisib in patients with advanced cancer and dose confirmation in uveal melanoma (part B).

Di Giacomo AM; Santangelo F; Amato G; Simonetti E; Graham J; Lahn MMF; Di Conza G; Hammett T; Zorrilla R; Durini M; Tan Z; Tadepally L; Brodin P; Occhipinti M; Simonelli M; Carlo-Stella C; Santoro A; Spiliopoulou P; Evans TRJ; Maio M
Journal article: JOURNAL OF IMMUNOLOGY. 2023;210(1_Supplement):233.07

Immune system perturbations in patients with severe long COVID

Rodriguez L; Tan Z; Lakshmikanth T; Wang J; Barcenilla H; Gonzalez L; Mugabo C; Johnsson A; Chen Y; Mikes J; Landegren N; Runold M; Bruchfeld J; Brodin P
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2023;220(5):e20220170

Humans with inherited MyD88 and IRAK-4 deficiencies are predisposed to hypoxemic COVID-19 pneumonia.

García-García A; Pérez de Diego R; Flores C; Rinchai D; Solé-Violán J; Deyà-Martínez À; García-Solis B; Lorenzo-Salazar JM; Hernández-Brito E; Lanz A-L; Moens L; Bucciol G; Almuqamam M; Domachowske JB; Colino E; Santos-Perez JL; Marco FM; Pignata C; Bousfiha A; Turvey SE; Bauer S; Haerynck F; Ocejo-Vinyals JG; Lendinez F; Prader S; Naumann-Bartsch N; Pachlopnik Schmid J; Biggs CM; Hildebrand K; Dreesman A; Cárdenes MÁ; Ailal F; Benhsaien I; Giardino G; Molina-Fuentes A; Fortuny C; Madhavarapu S; Conway DH; Prando C; Schidlowski L; Martínez de Saavedra Álvarez MT; Alfaro R; Rodríguez de Castro F; ESID Registry Working Party; COVID Human Genetic Effort; Meyts I; Hauck F; Puel A; Bastard P; Boisson B; Jouanguy E; Abel L; Cobat A; Zhang Q; Casanova J-L; Alsina L; Rodríguez-Gallego C
Article: THE LANCET REGIONAL HEALTH - EUROPE. 2023;28:100608

Ambient air pollution exposure linked to long COVID among young adults: a nested survey in a population-based cohort in Sweden.

Yu Z; Ekström S; Bellander T; Ljungman P; Pershagen G; Eneroth K; Kull I; Bergström A; Georgelis A; Stafoggia M; Gruzieva O; Melén E; BAMSE COVID-19 Study Group
Article: GENOME MEDICINE. 2023;15(1):22

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

Matuozzo D; Talouarn E; Marchal A; Zhang P; Manry J; Seeleuthner Y; Zhang Y; Bolze A; Chaldebas M; Milisavljevic B; Gervais A; Bastard P; Asano T; Bizien L; Barzaghi F; Abolhassani H; Abou Tayoun A; Aiuti A; Alavi Darazam I; Allende LM; Alonso-Arias R; Arias AA; Aytekin G; Bergman P; Bondesan S; Bryceson YT; Bustos IG; Cabrera-Marante O; Carcel S; Carrera P; Casari G; Chaïbi K; Colobran R; Condino-Neto A; Covill LE; Delmonte OM; El Zein L; Flores C; Gregersen PK; Gut M; Haerynck F; Halwani R; Hancerli S; Hammarström L; Hatipoğlu N; Karbuz A; Keles S; Kyheng C; Leon-Lopez R; Franco JL; Mansouri D; Martinez-Picado J; Metin Akcan O; Migeotte I; Morange P-E; Morelle G; Martin-Nalda A; Novelli G; Novelli A; Ozcelik T; Palabiyik F; Pan-Hammarström Q; de Diego RP; Planas-Serra L; Pleguezuelo DE; Prando C; Pujol A; Reyes LF; Rivière JG; Rodriguez-Gallego C; Rojas J; Rovere-Querini P; Schlüter A; Shahrooei M; Sobh A; Soler-Palacin P; Tandjaoui-Lambiotte Y; Tipu I; Tresoldi C; Troya J; van de Beek D; Zatz M; Zawadzki P; Al-Muhsen SZ; Alosaimi MF; Alsohime FM; Baris-Feldman H; Butte MJ; Constantinescu SN; Cooper MA; Dalgard CL; Fellay J; Heath JR; Lau Y-L; Lifton RP; Maniatis T; Mogensen TH; von Bernuth H; Lermine A; Vidaud M; Boland A; Deleuze J-F; Nussbaum R; Kahn-Kirby A; Mentre F; Tubiana S; Gorochov G; Tubach F; Hausfater P; COVID Human Genetic Effort; COVIDeF Study Group; French COVID Cohort Study Group; CoV-Contact Cohort; COVID-STORM Clinicians; COVID Clinicians; Orchestra Working Group; Amsterdam UMC Covid-19 Biobank; NIAID-USUHS COVID Study Group; Meyts I; Zhang S-Y; Puel A; Notarangelo LD; Boisson-Dupuis S; Su HC; Boisson B; Jouanguy E; Casanova J-L; Zhang Q; Abel L; Cobat A
Article: LANCET RHEUMATOLOGY. 2023;5(4):e184-e199

Immunoglobulin, glucocorticoid, or combination therapy for multisystem inflammatory syndrome in children: a propensity-weighted cohort study.

Channon-Wells S; Vito O; McArdle AJ; Seaby EG; Patel H; Shah P; Pazukhina E; Wilson C; Broderick C; D'Souza G; Keren I; Nijman RG; Tremoulet A; Munblit D; Ulloa-Gutierrez R; Carter MJ; Ramnarayan P; De T; Hoggart C; Whittaker E; Herberg JA; Kaforou M; Cunnington AJ; Blyuss O; Levin M; Best Available Treatment Study (BATS) consortium
Article: SCIENCE. 2023;379(6632):eabo3627

Inborn errors of OAS-RNase L in SARS-CoV-2-related multisystem inflammatory syndrome in children.

Lee D; Le Pen J; Yatim A; Dong B; Aquino Y; Ogishi M; Pescarmona R; Talouarn E; Rinchai D; Zhang P; Perret M; Liu Z; Jordan I; Elmas Bozdemir S; Bayhan GI; Beaufils C; Bizien L; Bisiaux A; Lei W; Hasan M; Chen J; Gaughan C; Asthana A; Libri V; Luna JM; Jaffré F; Hoffmann H-H; Michailidis E; Moreews M; Seeleuthner Y; Bilguvar K; Mane S; Flores C; Zhang Y; Arias AA; Bailey R; Schlüter A; Milisavljevic B; Bigio B; Le Voyer T; Materna M; Gervais A; Moncada-Velez M; Pala F; Lazarov T; Levy R; Neehus A-L; Rosain J; Peel J; Chan Y-H; Morin M-P; Pino-Ramirez RM; Belkaya S; Lorenzo L; Anton J; Delafontaine S; Toubiana J; Bajolle F; Fumadó V; DeDiego ML; Fidouh N; Rozenberg F; Pérez-Tur J; Chen S; Evans T; Geissmann F; Lebon P; Weiss SR; Bonnet D; Duval X; CoV-Contact Cohort§; COVID Human Genetic Effort¶; Pan-Hammarström Q; Planas AM; Meyts I; Haerynck F; Pujol A; Sancho-Shimizu V; Dalgard CL; Bustamante J; Puel A; Boisson-Dupuis S; Boisson B; Maniatis T; Zhang Q; Bastard P; Notarangelo L; Béziat V; Perez de Diego R; Rodriguez-Gallego C; Su HC; Lifton RP; Jouanguy E; Cobat A; Alsina L; Keles S; Haddad E; Abel L; Belot A; Quintana-Murci L; Rice CM; Silverman RH; Zhang S-Y; Casanova J-L
Article: OXFORD OPEN IMMUNOLOGY. 2023;4(1):iqad003

Achieving symptom relief in patients with myalgic encephalomyelitis by targeting the neuro-immune interface and optimizing disease tolerance.

Rodriguez L; Pou C; Lakshmikanth T; Zhang J; Mugabo CH; Wang J; Mikes J; Olin A; Chen Y; Rorbach J; Juto J-E; Li TQ; Julin P; Brodin P
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2023;43(1):136-150

Three Adult Cases of STAT1 Gain-of-Function with Chronic Mucocutaneous Candidiasis Treated with JAK Inhibitors.

Borgström EW; Edvinsson M; Pérez LP; Norlin AC; Enoksson SL; Hansen S; Fasth A; Friman V; Kämpe O; Månsson R; Estupiñán HY; Wang Q; Ziyang T; Lakshmikanth T; Smith CIE; Brodin P; Bergman P
Article: CELL REPORTS MEDICINE. 2022;3(11):100804

Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort.

Sugrue JA; Posseme C; Tan Z; Pou C; Charbit B; Bondet V; Bourke NM; Brodin P; Duffy D; O'Farrelly C
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(11):e20220514

Autoantibodies against type I IFNs in patients with critical influenza pneumonia.

Zhang Q; Pizzorno A; Miorin L; Bastard P; Gervais A; Le Voyer T; Bizien L; Manry J; Rosain J; Philippot Q; Goavec K; Padey B; Cupic A; Laurent E; Saker K; Vanker M; Särekannu K; COVID Human Genetic Effort; Etablissement Français du Sang Study Group; Constances Cohort; 3C-Dijon Study; Cerba HealthCare Group; Lyon Antigrippe Working Group; REIPI INF Working Group; García-Salum T; Ferres M; Le Corre N; Sánchez-Céspedes J; Balsera-Manzanero M; Carratala J; Retamar-Gentil P; Abelenda-Alonso G; Valiente A; Tiberghien P; Zins M; Debette S; Meyts I; Haerynck F; Castagnoli R; Notarangelo LD; Gonzalez-Granado LI; Dominguez-Pinilla N; Andreakos E; Triantafyllia V; Rodríguez-Gallego C; Solé-Violán J; Ruiz-Hernandez JJ; Rodríguez de Castro F; Ferreres J; Briones M; Wauters J; Vanderbeke L; Feys S; Kuo C-Y; Lei W-T; Ku C-L; Tal G; Etzioni A; Hanna S; Fournet T; Casalegno J-S; Queromes G; Argaud L; Javouhey E; Rosa-Calatrava M; Cordero E; Aydillo T; Medina RA; Kisand K; Puel A; Jouanguy E; Abel L; Cobat A; Trouillet-Assant S; García-Sastre A; Casanova J-L
Article: NATURE COMMUNICATIONS. 2022;13(1):5895

The immune factors driving DNA methylation variation in human blood.

Bergstedt J; Azzou SAK; Tsuo K; Jaquaniello A; Urrutia A; Rotival M; Lin DTS; MacIsaac JL; Kobor MS; Albert ML; Duffy D; Patin E; Quintana-Murci L; Milieu Intérieur Consortium
Article: MOLECULAR ONCOLOGY. 2022;16(19):3452-3464

Prostate cancer disease recurrence after radical prostatectomy is associated with HLA type and local cytomegalovirus immunity.

Classon J; Zamboni M; Engblom C; Alkass K; Mantovani G; Pou C; Nkulikiyimfura D; Brodin P; Druid H; Mold J; Frisén J
Article: BMC PEDIATRICS. 2022;22(1):565

Transplantation of maternal intestinal flora to the newborn after elective cesarean section (SECFLOR): study protocol for a double blinded randomized controlled trial.

Carpén N; Brodin P; de Vos WM; Salonen A; Kolho K-L; Andersson S; Helve O
Article: SCIENTIFIC REPORTS. 2022;12(1):14937

Selective transfer of maternal antibodies in preterm and fullterm children.

Dolatshahi S; Butler AL; Pou C; Henckel E; Bernhardsson AK; Gustafsson A; Bohlin K; Shin SA; Lauffenburger DA; Brodin P; Alter G
Article: ALLERGY. 2022;77(8):2415-2430

Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures.

Taeschler P; Cervia C; Zurbuchen Y; Hasler S; Pou C; Tan Z; Adamo S; Raeber ME; Bächli E; Rudiger A; Stüssi-Helbling M; Huber LC; Brodin P; Nilsson J; Probst-Müller E; Boyman O
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(8):e20220131

Recessive inborn errors of type I IFN immunity in children with COVID-19 pneumonia.

Zhang Q; Matuozzo D; Le Pen J; Lee D; Moens L; Asano T; Bohlen J; Liu Z; Moncada-Velez M; Kendir-Demirkol Y; Jing H; Bizien L; Marchal A; Abolhassani H; Delafontaine S; Bucciol G; COVID Human Genetic Effort; Bayhan GI; Keles S; Kiykim A; Hancerli S; Haerynck F; Florkin B; Hatipoglu N; Ozcelik T; Morelle G; Zatz M; Ng LFP; Lye DC; Young BE; Leo Y-S; Dalgard CL; Lifton RP; Renia L; Meyts I; Jouanguy E; Hammarström L; Pan-Hammarström Q; Boisson B; Bastard P; Su HC; Boisson-Dupuis S; Abel L; Rice CM; Zhang S-Y; Cobat A; Casanova J-L
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2022;219(7):e20220202

Respiratory viral infections in otherwise healthy humans with inherited IRF7 deficiency.

Campbell TM; Liu Z; Zhang Q; Moncada-Velez M; Covill LE; Zhang P; Alavi Darazam I; Bastard P; Bizien L; Bucciol G; Lind Enoksson S; Jouanguy E; Karabela ŞN; Khan T; Kendir-Demirkol Y; Arias AA; Mansouri D; Marits P; Marr N; Migeotte I; Moens L; Ozcelik T; Pellier I; Sendel A; Şenoğlu, S; Shahrooei M; Smith CIE; Vandernoot I; Willekens K; Kart Yaşar K; COVID Human Genetic Effort; Bergman P; Abel L; Cobat A; Casanova J-L; Meyts I; Bryceson YT
Article: CELL REPORTS. 2022;39(13):110989

Early IFNβ secretion determines variable downstream IL-12p70 responses upon TLR4 activation.

Posseme C; Llibre A; Charbit B; Bondet V; Rouilly V; Saint-André V; Boussier J; Bergstedt J; Smith N; Townsend L; Sugrue JA; Ní Cheallaigh C; Conlon N; Rotival M; Kobor MS; Mottez E; Pol S; Patin E; Albert ML; Quintana-Murci L; Duffy D; Milieu Intérieur Consortium
Journal article: FRONTIERS IN SYSTEMS BIOLOGY. 2022;2:918792

Data Availability of Open T-Cell Receptor Repertoire Data, a Systematic Assessment

Huang Y-N; Patel NA; Mehta JH; Ginjala S; Brodin P; Gray CM; Patel YM; Cowell LG; Burkhardt AM; Mangul S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(21):e2200413119

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies.

Manry J; Bastard P; Gervais A; Le Voyer T; Rosain J; Philippot Q; Michailidis E; Hoffmann H-H; Eto S; Garcia-Prat M; Bizien L; Parra-Martínez A; Yang R; Haljasmägi L; Migaud M; Särekannu K; Maslovskaja J; de Prost N; Tandjaoui-Lambiotte Y; Luyt C-E; Amador-Borrero B; Gaudet A; Poissy J; Morel P; Richard P; Cognasse F; Troya J; Trouillet-Assant S; Belot A; Saker K; Garçon P; Rivière JG; Lagier J-C; Gentile S; Rosen LB; Shaw E; Morio T; Tanaka J; Dalmau D; Tharaux P-L; Sene D; Stepanian A; Mégarbane B; Triantafyllia V; Fekkar A; Heath JR; Franco JL; Anaya J-M; Solé-Violán J; Imberti L; Biondi A; Bonfanti P; Castagnoli R; Delmonte OM; Zhang Y; Snow AL; Holland SM; Biggs CM; Moncada-Vélez M; Arias AA; Lorenzo L; Boucherit S; Anglicheau D; Planas AM; Haerynck F; Duvlis S; Ozcelik T; Keles S; Bousfiha AA; El Bakkouri J; Ramirez-Santana C; Paul S; Pan-Hammarström Q; Hammarström L; Dupont A; Kurolap A; Metz CN; Aiuti A; Casari G; Lampasona V; Ciceri F; Barreiros LA; Dominguez-Garrido E; Vidigal M; Zatz M; van de Beek D; Sahanic S; Tancevski I; Stepanovskyy Y; Boyarchuk O; Nukui Y; Tsumura M; Vidaur L; Tangye SG; Burrel S; Duffy D; Quintana-Murci L; Klocperk A; Kann NY; Shcherbina A; Lau Y-L; Leung D; Coulongeat M; Marlet J; Koning R; Reyes LF; Chauvineau-Grenier A; Venet F; Monneret G; Nussenzweig MC; Arrestier R; Boudhabhay I; Baris-Feldman H; Hagin D; Wauters J; Meyts I; Dyer AH; Kennelly SP; Bourke NM; Halwani R; Sharif-Askari FS; Dorgham K; Sallette J; Sedkaoui SM; AlKhater S; Rigo-Bonnin R; Morandeira F; Roussel L; Vinh DC; Erikstrup C; Condino-Neto A; Prando C; Bondarenko A; Spaan AN; Gilardin L; Fellay J; Lyonnet S; Bilguvar K; Lifton RP; Mane S; HGID Lab; COVID Clinicians; COVID-STORM Clinicians; NIAID Immune Response to COVID Group; NH-COVAIR Study Group; Danish CHGE; Danish Blood Donor Study; St. James's Hospital, SARS CoV2 Interest Group; French COVID Cohort Study Group; Imagine COVID-Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank Investigators; COVID Human Genetic Effort; CP-COVID-19 Group; CONSTANCES cohort; 3C-Dijon Study; Cerba Health-Care; Etablissement Français du Sang Study group; Anderson MS; Boisson B; Béziat V; Zhang S-Y; Andreakos E; Hermine O; Pujol A; Peterson P; Mogensen TH; Rowen L; Mond J; Debette S; de Lamballerie X; Burdet C; Bouadma L; Zins M; Soler-Palacin P; Colobran R; Gorochov G; Solanich X; Susen S; Martinez-Picado J; Raoult D; Vasse M; Gregersen PK; Piemonti L; Rodríguez-Gallego C; Notarangelo LD; Su HC; Kisand K; Okada S; Puel A; Jouanguy E; Rice CM; Tiberghien P; Zhang Q; Casanova J-L; Abel L; Cobat A
Article: ALLERGY. 2022;77(5):1583-1595

Longitudinal analyses of development of the immune system during the first five years of life in relation to lifestyle.

Olin A; Acevedo N; Lakshmikanth T; Chen Y; Johansson C; Alm J; Scheynius A; Brodin P
Article: J ALLERGY CLIN IMMUNOL GLOB. 2022;1(2):37-42

Lung function before and after COVID-19 in young adults: A population-based study.

Mogensen I; Hallberg J; Björkander S; Du L; Zuo F; Hammarström L; Pan-Hammarström Q; Ekström S; Georgelis A; Palmberg L; Janson C; Bergström A; Melén E; Kull I; BAMSE COVID-19 Study Group
Article: GENES AND IMMUNITY. 2022;23(2):93-98

Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus.

Sugrue JA; Smith M; Posseme C; Charbit B; Milieu Interieur Consortium; Bourke NM; Duffy D; O'Farrelly C
Article: JAMA NETWORK OPEN. 2022;5(4):e228109

Association of Short-term Air Pollution Exposure With SARS-CoV-2 Infection Among Young Adults in Sweden.

Yu Z; Bellander T; Bergström A; Dillner J; Eneroth K; Engardt M; Georgelis A; Kull I; Ljungman P; Pershagen G; Stafoggia M; Melén E; Gruzieva O; BAMSE COVID-19 Study Group
Article: GENOME MEDICINE. 2022;14(1):28

Integrative genetic and immune cell analysis of plasma proteins in healthy donors identifies novel associations involving primary immune deficiency genes.

Caron B; Patin E; Rotival M; Charbit B; Albert ML; Quintana-Murci L; Duffy D; Rausell A; Milieu Intérieur Consortium
Article: NATURE IMMUNOLOGY. 2022;23(2):159-164

A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection.

Andreakos E; Abel L; Vinh DC; Kaja E; Drolet BA; Zhang Q; O'Farrelly C; Novelli G; Rodríguez-Gallego C; Haerynck F; Prando C; Pujol A; COVID Human Genetic Effort; Su HC; Casanova J-L; Spaan AN
Article: ACTA PAEDIATRICA. 2022;111(2):354-362

Population-based study of multisystem inflammatory syndrome associated with COVID-19 found that 36% of children had persistent symptoms.

Kahn R; Berg S; Berntson L; Berthold E; Brodin P; Bäckström F; Compagno M; Fasth A; Lingman Framme J; Horne A; Hätting J; Król P; Kukka AJ; Mossberg M; Månsson B; Nordenhäll C; Idring Nordström S; Khammari Nyström F; Palmblad K; Rasti R; Rudolph A; Rydenman K; Sundberg E; Säve-Söderbergh E; Altman M
Article: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2022;149(1):65-75.e8

SARS-CoV-2-specific B- and T-cell immunity in a population-based study of young Swedish adults.

Björkander S; Du L; Zuo F; Ekström S; Wang Y; Wan H; Sherina N; Schoutens L; Andréll J; Andersson N; Georgelis A; Bergström A; Marcotte H; Kull I; Hammarström L; Melén E; Pan-Hammarström Q; BAMSE COVID-19 study group
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(12):2791-2796

From Your Nose to Your Toes: A Review of Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic‒Associated Pernio.

Arkin LM; Moon JJ; Tran JM; Asgari S; O'Farrelly C; Casanova J-L; Cowen EW; Mays JW; Singh AM; Drolet BA; COVID Human Genetic Effort
Article: PEDIATRIC ALLERGY AND IMMUNOLOGY. 2021;32(8):1833-1842

Virological and immunological features of SARS-COV-2 infected children with distinct symptomatology.

Cotugno N; Ruggiero A; Pascucci GR; Bonfante F; Petrara MR; Pighi C; Cifaldi L; Zangari P; Bernardi S; Cursi L; Santilli V; Manno EC; Amodio D; Linardos G; Piccioni L; Barbieri MA; Perrotta D; Campana A; Donà D; Giaquinto C; CACTUS Study Team; Concato C; Brodin P; Rossi P; De Rossi A; Palma P
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4348

X-linked recessive TLR7 deficiency in ~1% of men under 60 years old with life-threatening COVID-19.

Asano T; Boisson B; Onodi F; Matuozzo D; Moncada-Velez M; Maglorius Renkilaraj MRL; Zhang P; Meertens L; Bolze A; Materna M; Korniotis S; Gervais A; Talouarn E; Bigio B; Seeleuthner Y; Bilguvar K; Zhang Y; Neehus A-L; Ogishi M; Pelham SJ; Le Voyer T; Rosain J; Philippot Q; Soler-Palacín P; Colobran R; Martin-Nalda A; Rivière JG; Tandjaoui-Lambiotte Y; Chaïbi K; Shahrooei M; Darazam IA; Olyaei NA; Mansouri D; Hatipoğlu N; Palabiyik F; Ozcelik T; Novelli G; Novelli A; Casari G; Aiuti A; Carrera P; Bondesan S; Barzaghi F; Rovere-Querini P; Tresoldi C; Franco JL; Rojas J; Reyes LF; Bustos IG; Arias AA; Morelle G; Christèle K; Troya J; Planas-Serra L; Schlüter A; Gut M; Pujol A; Allende LM; Rodriguez-Gallego C; Flores C; Cabrera-Marante O; Pleguezuelo DE; de Diego RP; Keles S; Aytekin G; Akcan OM; Bryceson YT; Bergman P; Brodin P; Smole D; Smith CIE; Norlin A-C; Campbell TM; Covill LE; Hammarström L; Pan-Hammarström Q; Abolhassani H; Mane S; Marr N; Ata M; Al Ali F; Khan T; Spaan AN; Dalgard CL; Bonfanti P; Biondi A; Tubiana S; Burdet C; Nussbaum R; Kahn-Kirby A; Snow AL; COVID Human Genetic Effort; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-; Biobank; NIAID-USUHS COVID Study Group; Bustamante J; Puel A; Boisson-Dupuis S; Zhang S-Y; Béziat V; Lifton RP; Bastard P; Notarangelo LD; Abel L; Su HC; Jouanguy E; Amara A; Soumelis V; Cobat A; Zhang Q; Casanova J-L
Article: SCIENCE IMMUNOLOGY. 2021;6(62):eabl4340

Autoantibodies neutralizing type I IFNs are present in ~4% of uninfected individuals over 70 years old and account for ~20% of COVID-19 deaths.

Bastard P; Gervais A; Le Voyer T; Rosain J; Philippot Q; Manry J; Michailidis E; Hoffmann H-H; Eto S; Garcia-Prat M; Bizien L; Parra-Martínez A; Yang R; Haljasmägi L; Migaud M; Särekannu K; Maslovskaja J; de Prost N; Tandjaoui-Lambiotte Y; Luyt C-E; Amador-Borrero B; Gaudet A; Poissy J; Morel P; Richard P; Cognasse F; Troya J; Trouillet-Assant S; Belot A; Saker K; Garçon P; Rivière JG; Lagier J-C; Gentile S; Rosen LB; Shaw E; Morio T; Tanaka J; Dalmau D; Tharaux P-L; Sene D; Stepanian A; Megarbane B; Triantafyllia V; Fekkar A; Heath JR; Franco JL; Anaya J-M; Solé-Violán J; Imberti L; Biondi A; Bonfanti P; Castagnoli R; Delmonte OM; Zhang Y; Snow AL; Holland SM; Biggs C; Moncada-Vélez M; Arias AA; Lorenzo L; Boucherit S; Coulibaly B; Anglicheau D; Planas AM; Haerynck F; Duvlis S; Nussbaum RL; Ozcelik T; Keles S; Bousfiha AA; El Bakkouri J; Ramirez-Santana C; Paul S; Pan-Hammarström Q; Hammarström L; Dupont A; Kurolap A; Metz CN; Aiuti A; Casari G; Lampasona V; Ciceri F; Barreiros LA; Dominguez-Garrido E; Vidigal M; Zatz M; van de Beek D; Sahanic S; Tancevski I; Stepanovskyy Y; Boyarchuk O; Nukui Y; Tsumura M; Vidaur L; Tangye SG; Burrel S; Duffy D; Quintana-Murci L; Klocperk A; Kann NY; Shcherbina A; Lau Y-L; Leung D; Coulongeat M; Marlet J; Koning R; Reyes LF; Chauvineau-Grenier A; Venet F; Monneret G; Nussenzweig MC; Arrestier R; Boudhabhay I; Baris-Feldman H; Hagin D; Wauters J; Meyts I; Dyer AH; Kennelly SP; Bourke NM; Halwani R; Sharif-Askari NS; Dorgham K; Sallette J; Sedkaoui SM; AlKhater S; Rigo-Bonnin R; Morandeira F; Roussel L; Vinh DC; Ostrowski SR; Condino-Neto A; Prando C; Bonradenko A; Spaan AN; Gilardin L; Fellay J; Lyonnet S; Bilguvar K; Lifton RP; Mane S; HGID Lab; COVID Clinicians; COVID-STORM Clinicians; NIAID Immune Response to COVID Group; NH-COVAIR Study Group; Danish CHGE; Danish Blood Donor Study; St. James's Hospital; SARS CoV2 Interest group; French COVID Cohort Study Group; Imagine COVID-Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19; Biobank Investigators; COVID Human Genetic Effort; CONSTANCES cohort; 3C-Dijon Study; Cerba Health-Care; Etablissement du Sang study group; Anderson MS; Boisson B; Béziat V; Zhang S-Y; Vandreakos E; Hermine O; Pujol A; Peterson P; Mogensen TH; Rowen L; Mond J; Debette S; de Lamballerie X; Duval X; Mentré F; Zins M; Soler-Palacin P; Colobran R; Gorochov G; Solanich X; Susen S; Martinez-Picado J; Raoult D; Vasse M; Gregersen PK; Piemonti L; Rodríguez-Gallego C; Notarangelo LD; Su HC; Kisand K; Okada S; Puel A; Jouanguy E; Rice CM; Tiberghien P; Zhang Q; Cobat A; Abel L; Casanova J-L
Article: JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH. 2021;40(1):240

A vision of immuno-oncology: the Siena think tank of the Italian network for tumor biotherapy (NIBIT) foundation.

Maio M; Lahn M; Di Giacomo AM; Covre A; Calabrò L; Ibrahim R; Fox B; Siena Think Tank
Article: CELL. 2021;184(15):3884-3898.e11

Bifidobacteria-mediated immune system imprinting early in life.

Henrick BM; Rodriguez L; Lakshmikanth T; Pou C; Henckel E; Arzoomand A; Olin A; Wang J; Mikes J; Tan Z; Chen Y; Ehrlich AM; Bernhardsson AK; Mugabo CH; Ambrosiani Y; Gustafsson A; Chew S; Brown HK; Prambs J; Bohlin K; Mitchell RD; Underwood MA; Smilowitz JT; German JB; Frese SA; Brodin P
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2021;385(1):11-22

Treatment of Multisystem Inflammatory Syndrome in Children.

McArdle AJ; Vito O; Patel H; Seaby EG; Shah P; Wilson C; Broderick C; Nijman R; Tremoulet AH; Munblit D; Ulloa-Gutierrez R; Carter MJ; De T; Hoggart C; Whittaker E; Herberg JA; Kaforou M; Cunnington AJ; Levin M; BATS Consortium
Article: LAKARTIDNINGEN. 2021;118:21136

Viktigt att uppmärksamma MIS-A inom vuxensjukvården.

Brodin P
Article: PSYCHONEUROENDOCRINOLOGY. 2021;126:105162

Autoantibodies against the C-terminus of Lipopolysaccharide binding protein are elevated in young adults with psychiatric disease.

Just D; Rasmusson AJ; Nilsson P; Noreland M; Malmström E; Brodin P; Månberg A; Cunningham JL
Article: CELL REPORTS. 2021;34(11):108852

Virological and immunological features of SARS-CoV-2-infected children who develop neutralizing antibodies.

Cotugno N; Ruggiero A; Bonfante F; Petrara MR; Zicari S; Pascucci GR; Zangari P; De Ioris MA; Santilli V; Manno EC; Amodio D; Bortolami A; Pagliari M; Concato C; Linardos G; Campana A; Donà D; Giaquinto C; CACTUS Study Team; Brodin P; Rossi P; De Rossi A; Palma P
Article: PEDIATRIC RESEARCH. 2021;89(3):604-612

Dramatic changes in blood protein levels during the first week of life in extremely preterm infants.

Zhong W; Danielsson H; Tebani A; Karlsson MJ; Elfvin A; Hellgren G; Brusselaers N; Brodin P; Hellström A; Fagerberg L; Uhlén M
Article: IMMUNITY & AGEING. 2021;18(1):5

Aging and CMV discordance are associated with increased immune diversity between monozygotic twins.

Yan Z; Maecker HT; Brodin P; Nygaard UC; Lyu SC; Davis MM; Nadeau KC; Andorf S
Article: NATURE MEDICINE. 2021;27(1):28-33

Immune determinants of COVID-19 disease presentation and severity.

Brodin P
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:727300

High Dimensional Immune Profiling Reveals Different Response Patterns in Active and Latent Tuberculosis Following Stimulation With Mycobacterial Glycolipids.

Silva CS; Sundling C; Folkesson E; Fröberg G; Nobrega C; Canto-Gomes J; Chambers BJ; Lakshmikanth T; Brodin P; Bruchfeld J; Nigou J; Correia-Neves M; Källenius G
Article: MED. 2020;1(1):14-20

Life-Threatening COVID-19: Defective Interferons Unleash Excessive Inflammation.

Zhang Q; Bastard P; Bolze A; Jouanguy E; Zhang S-Y; COVID Human Genetic Effort; Cobat A; Notarangelo LD; Su HC; Abel L; Casanova J-L
Article: SCIENTIFIC REPORTS. 2020;10(1):20425

High CD45 expression of CD8+ and CD4+ T cells correlates with the size of HIV-1 reservoir in blood.

Petkov S; Bekele Y; Lakshmikanth T; Hejdeman B; Zazzi M; Brodin P; Chiodi F
Article: CELL. 2020;183(4):968-981.e7

The Immunology of Multisystem Inflammatory Syndrome in Children with COVID-19.

Consiglio CR; Cotugno N; Sardh F; Pou C; Amodio D; Rodriguez L; Tan Z; Zicari S; Ruggiero A; Pascucci GR; Santilli V; Campbell T; Bryceson Y; Eriksson D; Wang J; Marchesi A; Lakshmikanth T; Campana A; Villani A; Rossi P; CACTUS Study Team; Landegren N; Palma P; Brodin P
Article: SCIENCE. 2020;370(6515):eabd4570

Inborn errors of type I IFN immunity in patients with life-threatening COVID-19.

Zhang Q; Bastard P; Liu Z; Le Pen J; Moncada-Velez M; Chen J; Ogishi M; Sabli IKD; Hodeib S; Korol C; Rosain J; Bilguvar K; Ye J; Bolze A; Bigio B; Yang R; Arias AA; Zhou Q; Zhang Y; Onodi F; Korniotis S; Karpf L; Philippot Q; Chbihi M; Bonnet-Madin L; Dorgham K; Smith N; Schneider WM; Razooky BS; Hoffmann H-H; Michailidis E; Moens L; Han JE; Lorenzo L; Bizien L; Meade P; Neehus A-L; Ugurbil AC; Corneau A; Kerner G; Zhang P; Rapaport F; Seeleuthner Y; Manry J; Masson C; Schmitt Y; Schlüter A; Le Voyer T; Khan T; Li J; Fellay J; Roussel L; Shahrooei M; Alosaimi MF; Mansouri D; Al-Saud H; Al-Mulla F; Almourfi F; Al-Muhsen SZ; Alsohime F; Al Turki S; Hasanato R; van de Beek D; Biondi A; Bettini LR; D'Angio' M; Bonfanti P; Imberti L; Sottini A; Paghera S; Quiros-Roldan E; Rossi C; Oler AJ; Tompkins MF; Alba C; Vandernoot I; Goffard J-C; Smits G; Migeotte I; Haerynck F; Soler-Palacin P; Martin-Nalda A; Colobran R; Morange P-E; Keles S; Çölkesen F; Ozcelik T; Yasar KK; Senoglu S; Karabela ŞN; Rodríguez-Gallego C; Novelli G; Hraiech S; Tandjaoui-Lambiotte Y; Duval X; Laouénan C; COVID-STORM Clinicians; COVID Clinicians; Imagine COVID Group; French COVID Cohort Study Group; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort; NIAID-USUHS/TAGC COVID Immunity Group; Snow AL; Dalgard CL; Milner JD; Vinh DC; Mogensen TH; Marr N; Spaan AN; Boisson B; Boisson-Dupuis S; Bustamante J; Puel A; Ciancanelli MJ; Meyts I; Maniatis T; Soumelis V; Amara A; Nussenzweig M; García-Sastre A; Krammer F; Pujol A; Duffy D; Lifton RP; Zhang S-Y; Gorochov G; Béziat V; Jouanguy E; Sancho-Shimizu V; Rice CM; Abel L; Notarangelo LD; Cobat A; Su HC; Casanova J-L
Article: SCIENCE. 2020;370(6515):eabd4585

Autoantibodies against type I IFNs in patients with life-threatening COVID-19.

Bastard P; Rosen LB; Zhang Q; Michailidis E; Hoffmann H-H; Zhang Y; Dorgham K; Philippot Q; Rosain J; Béziat V; Manry J; Shaw E; Haljasmägi L; Peterson P; Lorenzo L; Bizien L; Trouillet-Assant S; Dobbs K; de Jesus AA; Belot A; Kallaste A; Catherinot E; Tandjaoui-Lambiotte Y; Le Pen J; Kerner G; Bigio B; Seeleuthner Y; Yang R; Bolze A; Spaan AN; Delmonte OM; Abers MS; Aiuti A; Casari G; Lampasona V; Piemonti L; Ciceri F; Bilguvar K; Lifton RP; Vasse M; Smadja DM; Migaud M; Hadjadj J; Terrier B; Duffy D; Quintana-Murci L; van de Beek D; Roussel L; Vinh DC; Tangye SG; Haerynck F; Dalmau D; Martinez-Picado J; Brodin P; Nussenzweig MC; Boisson-Dupuis S; Rodríguez-Gallego C; Vogt G; Mogensen TH; Oler AJ; Gu J; Burbelo PD; Cohen JI; Biondi A; Bettini LR; D'Angio M; Bonfanti P; Rossignol P; Mayaux J; Rieux-Laucat F; Husebye ES; Fusco F; Ursini MV; Imberti L; Sottini A; Paghera S; Quiros-Roldan E; Rossi C; Castagnoli R; Montagna D; Licari A; Marseglia GL; Duval X; Ghosn J; HGID Lab; NIAID-USUHS Immune Response to COVID Group; COVID Clinicians; COVID-STORM Clinicians; Imagine COVID Group; French COVID Cohort Study Group; Milieu Intérieur Consortium; CoV-Contact Cohort; Amsterdam UMC Covid-19 Biobank; COVID Human Genetic Effort; Tsang JS; Goldbach-Mansky R; Kisand K; Lionakis MS; Puel A; Zhang S-Y; Holland SM; Gorochov G; Jouanguy E; Rice CM; Cobat A; Notarangelo LD; Abel L; Su HC; Casanova J-L
Article: NATURE COMMUNICATIONS. 2020;11(1):4487

Integration of molecular profiles in a longitudinal wellness profiling cohort.

Tebani A; Gummesson A; Zhong W; Koistinen IS; Lakshmikanth T; Olsson LM; Boulund F; Neiman M; Stenlund H; Hellström C; Karlsson MJ; Arif M; Dodig-Crnković T; Mardinoglu A; Lee S; Zhang C; Chen Y; Olin A; Mikes J; Danielsson H; von Feilitzen K; Jansson P-A; Angerås O; Huss M; Kjellqvist S; Odeberg J; Edfors F; Tremaroli V; Forsström B; Schwenk JM; Nilsson P; Moritz T; Bäckhed F; Engstrand L; Brodin P; Bergström G; Uhlen M; Fagerberg L
Article: CELL REPORTS MEDICINE. 2020;1(5):100078

Systems-Level Immunomonitoring from Acute to Recovery Phase of Severe COVID-19.

Rodriguez L; Pekkarinen PT; Lakshmikanth T; Tan Z; Consiglio CR; Pou C; Chen Y; Mugabo CH; Nguyen NA; Nowlan K; Strandin T; Levanov L; Mikes J; Wang J; Kantele A; Hepojoki J; Vapalahti O; Heinonen S; Kekäläinen E; Brodin P
Article: CELL REPORTS. 2020;32(3):107923

Human Immune System Variation during 1 Year.

Lakshmikanth T; Muhammad SA; Olin A; Chen Y; Mikes J; Fagerberg L; Gummesson A; Bergström G; Uhlen M; Brodin P
Article: GENOME MEDICINE. 2020;12(1):25

Epigenome-wide meta-analysis of blood DNA methylation in newborns and children identifies numerous loci related to gestational age.

Merid SK; Novoloaca A; Sharp GC; Küpers LK; Kho AT; Roy R; Gao L; Annesi-Maesano I; Jain P; Plusquin M; Kogevinas M; Allard C; Vehmeijer FO; Kazmi N; Salas LA; Rezwan FI; Zhang H; Sebert S; Czamara D; Rifas-Shiman SL; Melton PE; Lawlor DA; Pershagen G; Breton CV; Huen K; Baiz N; Gagliardi L; Nawrot TS; Corpeleijn E; Perron P; Duijts L; Nohr EA; Bustamante M; Ewart SL; Karmaus W; Zhao S; Page CM; Herceg Z; Jarvelin M-R; Lahti J; Baccarelli AA; Anderson D; Kachroo P; Relton CL; Bergström A; Eskenazi B; Soomro MH; Vineis P; Snieder H; Bouchard L; Jaddoe VW; Sørensen TIA; Vrijheid M; Arshad SH; Holloway JW; Håberg SE; Magnus P; Dwyer T; Binder EB; DeMeo DL; Vonk JM; Newnham J; Tantisira KG; Kull I; Wiemels JL; Heude B; Sunyer J; Nystad W; Munthe-Kaas MC; Räikkönen K; Oken E; Huang R-C; Weiss ST; Antó JM; Bousquet J; Kumar A; Söderhäll C; Almqvist C; Cardenas A; Gruzieva O; Xu C-J; Reese SE; Kere J; Brodin P; Solomon O; Wielscher M; Holland N; Ghantous A; Hivert M-F; Felix JF; Koppelman GH; London SJ; Melén E
Article: SCIENCE. 2019;366(6472):eaax9198

A genome-wide transcriptomic analysis of protein-coding genes in human blood cells.

Uhlen M; Karlsson MJ; Zhong W; Tebani A; Pou C; Mikes J; Lakshmikanth T; Forsström B; Edfors F; Odeberg J; Mardinoglu A; Zhang C; von Feilitzen K; Mulder J; Sjöstedt E; Hober A; Oksvold P; Zwahlen M; Ponten F; Lindskog C; Sivertsson Å; Fagerberg L; Brodin P
Article: PLOS BIOLOGY. 2019;17(10):e3000383

Cell generation dynamics underlying naive T-cell homeostasis in adult humans.

Mold JE; Réu P; Olin A; Bernard S; Michaëlsson J; Rane S; Yates A; Khosravi A; Salehpour M; Possnert G; Brodin P; Frisén J
Article: ELIFE. 2019;8:e43578

Comment on 'AIRE-deficient patients harbor unique high-affinity disease-ameliorating autoantibodies'.

Landegren N; Rosen LB; Freyhult E; Eriksson D; Fall T; Smith G; Ferre EMN; Brodin P; Sharon D; Snyder M; Lionakis M; Anderson M; Kämpe O
Article: JCI INSIGHT. 2019;5(9):126492

B cell profiling in malaria reveals expansion and remodelling of CD11c+ B cell subsets.

Sundling C; Rönnberg C; Yman V; Asghar M; Jahnmatz P; Lakshmikanth T; Chen Y; Mikes J; Forsell MN; Sondén K; Achour A; Brodin P; Persson KE; Färnert A
Article: NATURE MEDICINE. 2019;25(4):591-596

The repertoire of maternal anti-viral antibodies in human newborns.

Pou C; Nkulikiyimfura D; Henckel E; Olin A; Lakshmikanth T; Mikes J; Wang J; Chen Y; Bernhardsson AK; Gustafsson A; Bohlin K; Brodin P
Article: JCI INSIGHT. 2019;4(3):e125442

Mass cytometry identifies distinct CD4+ T cell clusters distinguishing HIV-1-infected patients according to antiretroviral therapy initiation.

Bekele Y; Lakshmikanth T; Chen Y; Mikes J; Nasi A; Petkov S; Hejdeman B; Brodin P; Chiodi F
Article: EBIOMEDICINE. 2019;40:517-527

B cell alterations during BAFF inhibition with belimumab in SLE.

Ramsköld D; Parodis I; Lakshmikanth T; Sippl N; Khademi M; Chen Y; Zickert A; Mikeš J; Achour A; Amara K; Piehl F; Brodin P; Gunnarsson I; Malmström V
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1913:33-48

Systems-Level Immune Monitoring by Mass Cytometry.

Lakshmikanth T; Brodin P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2019;89(1):e12732

Effect of CTLA4-Ig (abatacept) treatment on T cells and B cells in peripheral blood of patients with polymyositis and dermatomyositis.

Tang Q; Ramsköld D; Krystufkova O; Mann HF; Wick C; Dastmalchi M; Lakshmikanth T; Chen Y; Mikes J; Alexanderson H; Achour A; Brodin P; Vencovsky J; Lundberg IE; Malmström V
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1989:111-123

Automated Cell Processing for Mass Cytometry Experiments.

Mikes J; Olin A; Lakshmikanth T; Chen Y; Brodin P
Article: CELL. 2018;174(5):1277-1292.e14

Stereotypic Immune System Development in Newborn Children.

Olin A; Henckel E; Chen Y; Lakshmikanth T; Pou C; Mikes J; Gustafsson A; Bernhardsson AK; Zhang C; Bohlin K; Brodin P
Article: CLINICAL IMMUNOLOGY. 2018;193:70-79

Plasmablast antibody repertoires in elderly influenza vaccine responders exhibit restricted diversity but increased breadth of binding across influenza strains.

Ju C-H; Blum LK; Kongpachith S; Lingampalli N; Mao R; Brodin P; Dekker CL; Davis MM; Robinson WH
Article: CELL METABOLISM. 2018;27(2):378-392.e5

Kynurenic Acid and Gpr35 Regulate Adipose Tissue Energy Homeostasis and Inflammation.

Agudelo LZ; Ferreira DMS; Cervenka I; Bryzgalova G; Dadvar S; Jannig PR; Pettersson-Klein AT; Lakshmikanth T; Sustarsic EG; Porsmyr-Palmertz M; Correia JC; Izadi M; Martínez-Redondo V; Ueland PM; Midttun Ø; Gerhart-Hines Z; Brodin P; Pereira T; Berggren P-O; Ruas JL
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2018;5:81

Continuous Immune Cell Differentiation Inferred From Single-Cell Measurements Following Allogeneic Stem Cell Transplantation.

Chen Y; Lakshmikanth T; Olin A; Mikes J; Remberger M; Brodin P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(3):135-142

The Abl-1 Kinase is Dispensable for NK Cell Inhibitory Signalling and is not Involved in Murine NK Cell Education.

Ganesan S; Luu TT; Chambers BJ; Meinke S; Brodin P; Vivier E; Wetzel DM; Koleske AJ; Kadri N; Höglund P
Article: CELL REPORTS. 2017;20(9):2238-2250

Mass Cytometry and Topological Data Analysis Reveal Immune Parameters Associated with Complications after Allogeneic Stem Cell Transplantation.

Lakshmikanth T; Olin A; Chen Y; Mikes J; Fredlund E; Remberger M; Omazic B; Brodin P
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2017;114(30):E6097-E6106

Continuous immunotypes describe human immune variation and predict diverse responses.

Kaczorowski KJ; Shekhar K; Nkulikiyimfura D; Dekker CL; Maecker H; Davis MM; Chakraborty AK; Brodin P
Article: NATURE COMMUNICATIONS. 2017;8:15627

Expression of CD226 is associated to but not required for NK cell education.

Wagner AK; Kadri N; Snäll J; Brodin P; Gilfillan S; Colonna M; Bernhardt G; Höglund P; Kärre K; Chambers BJ
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:717

Combining Flow and Mass Cytometry in the Search for Biomarkers in Chronic Graft-versus-Host Disease.

Stikvoort A; Chen Y; Rådestad E; Törlén J; Lakshmikanth T; Björklund A; Mikes J; Achour A; Gertow J; Sundberg B; Remberger M; Sundin M; Mattsson J; Brodin P; Uhlin M
Article: FRONTIERS IN IMMUNOLOGY. 2017;8:1130

Mass Cytometry Identifies Distinct Lung CD4+ T Cell Patterns in Löfgren's Syndrome and Non-Löfgren's Syndrome Sarcoidosis.

Kaiser Y; Lakshmikanth T; Chen Y; Mikes J; Eklund A; Brodin P; Achour A; Grunewald J
Article: HAEMATOLOGICA. 2015;100(11):1477-1485

Risks and benefits of sex-mismatched hematopoietic cell transplantation differ according to conditioning strategy.

Nakasone H; Remberger M; Tian L; Brodin P; Sahaf B; Wu F; Mattsson J; Lowsky R; Negrin R; Miklos DB; Meyer E
Article: CELL. 2015;160(1-2):37-47

Variation in the human immune system is largely driven by non-heritable influences.

Brodin P; Jojic V; Gao T; Bhattacharya S; Angel CJL; Furman D; Shen-Orr S; Dekker CL; Swan GE; Butte AJ; Maecker HT; Davis MM
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2014;111(1):202-207

Automatic Classification of Cellular Expression by Nonlinear Stochastic Embedding (ACCENSE).

Shekhar K; Brodin P; Davis MM; Chakraborty AK
Article: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. 2013;9(4):307-317

Systems level immune response analysis and personalized medicine.

Brodin P; Valentini D; Uhlin M; Mattsson J; Zumla A; Maeurer MJ
Article: FRONTIERS IN IMMUNOLOGY. 2013;4:65

Natural killer cell inhibitory receptor expression in humans and mice: a closer look.

Sternberg-Simon M; Brodin P; Pickman Y; Onfelt B; Kärre K; Malmberg K-J; Höglund P; Mehr R
Article: INTERNATIONAL JOURNAL OF HEMATOLOGY. 2012;96(6):798-800

Major surgery in a neutropenic patient undergoing allogeneic stem cell transplantation for high risk myelofibrosis.

Brodin P; Gilg S; Lundell L; Mattsson J
Article: ONCOGENESIS. 2012;1(3):e3

MicroRNA-203 functions as a tumor suppressor in basal cell carcinoma.

Sonkoly E; Lovén J; Xu N; Meisgen F; Wei T; Brodin P; Jaks V; Kasper M; Shimokawa T; Harada M; Heilborn J; Hedblad M-A; Hippe A; Grandér D; Homey B; Zaphiropoulos PG; Arsenian-Henriksson M; Ståhle M; Pivarcsi A
Article: JOURNAL OF IMMUNOLOGY. 2012;188(5):2218-2226

Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets.

Brodin P; Lakshmikanth T; Kärre K; Höglund P
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2011;131(7):1521-1529

MiR-125b, a microRNA downregulated in psoriasis, modulates keratinocyte proliferation by targeting FGFR2.

Xu N; Brodin P; Wei T; Meisgen F; Eidsmo L; Nagy N; Kemeny L; Ståhle M; Sonkoly E; Pivarcsi A
Article: PLOS ONE. 2010;5(10):e13174

Natural killer cell tolerance persists despite significant reduction of self MHC class I on normal target cells in mice.

Brodin P; Lakshmikanth T; Mehr R; Johansson MH; Duru AD; Achour A; Salmon-Divon M; Kärre K; Höglund P; Johansson S
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(4):1553-1558

MYCN-regulated microRNAs repress estrogen receptor-alpha (ESR1) expression and neuronal differentiation in human neuroblastoma.

Lovén J; Zinin N; Wahlström T; Müller I; Brodin P; Fredlund E; Ribacke U; Pivarcsi A; Påhlman S; Henriksson M
Article: JOURNAL OF NEUROSCIENCE. 2009;29(43):13503-13515

Classical major histocompatibility complex class I molecules in motoneurons: new actors at the neuromuscular junction.

Thams S; Brodin P; Plantman S; Saxelin R; Kärre K; Cullheim S
Article: PLOS ONE. 2009;4(6):e6046

Probing natural killer cell education by Ly49 receptor expression analysis and computational modelling in single MHC class I mice.

Johansson S; Salmon-Divon M; Johansson MH; Pickman Y; Brodin P; Kärre K; Mehr R; Höglund P
Article: IMMUNITY. 2009;30(3):337-347

A Role for cis Interaction between the Inhibitory Ly49A receptor and MHC class I for natural killer cell education.

Chalifour A; Scarpellino L; Back J; Brodin P; Devèvre E; Gros F; Lévy F; Leclercq G; Höglund P; Beermann F; Held W
Article: BLOOD. 2009;113(11):2434-2441

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells.

Brodin P; Lakshmikanth T; Johansson S; Kärre K; Höglund P
Article: JOURNAL OF IMMUNOLOGY. 2009;182(3):1460-1468

Distinct and overlapping patterns of cytokine regulation of thymic and bone marrow-derived NK cell development.

Cheng M; Charoudeh HN; Brodin P; Tang Y; Lakshmikanth T; Höglund P; Jacobsen SEW; Sitnicka E
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2008;38(11):2934-2937

Beyond licensing and disarming: a quantitative view on NK-cell education.

Brodin P; Höglund P
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;67(1):1-11

IFN-gamma production and degranulation are differentially regulated in response to stimulation in murine natural killer cells.

Vahlne G; Becker S; Brodin P; Johansson MH
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;67(1):30-36

Critical role of Qa1b in the protection of mature dendritic cells from NK cell-mediated killing.

Persson CM; Assarsson E; Vahlne G; Brodin P; Chambers BJ
Visa fler

Alla övriga publikationer

Preprint: BIORXIV. 2024

Cluster-free annotation of single cells using Earth mover’s distance-based classification

Forlin R; Tajvar P; Wang N; Dimarogonas D; Brodin P
Preprint: RESEARCH SQUARE. 2024

Fetal-maternal interactions with gluten immunogenic peptides during pregnancy: a new determinant on the coeliac exposome

Moreno MDL; González-Rovira M; Martínez-Pancorbo C; Martín-Cameán M; Nájar-Moyano AM; Romero M; Hoz E; López-Beltrán C; Mellado E; Bartha JL; Brodin P; Rodríguez-Herrera A; Sainz-Bueno JL; Sousa C
Editorial comment: TRENDS IN MOLECULAR MEDICINE. 2024;30(3):200-201

Immune system perturbations in patients with long COVID.

Rodriguez L; Brodin P
Preprint: MEDRXIV. 2024

Restrained memory CD8⁺T cell responses favors viral persistence and elevated IgG responses in patients with severe Long COVID

Rodriguez L; Tan Z; Lakshmikanth T; Wang J; Barcenilla H; Swank Z; Zuo F; Abolhassani H; Pavlovitch-Bedzyk AJ; Wang C; Gonzalez L; Mugabo CH; Johnsson A; Chen Y; James A; Mikes J; Kleberg L; Sundling C; Björnson M; Bonnier MN; Ståhlberg M; Runold M; Björkander S; Melén E; Meyts I; Weyenbergh JV; Hammarström Q-P; Davis M; Walt D; Landegren N; Aiuti A; Casari G; Casanova J-L; Jamoulle M; Bruchfeld J; Brodin P; COVID Human Genetic Effort
Preprint: BIORXIV. 2024

High-throughput analysis of membrane fluidity unveils a hidden dimension in immune cell states

Andronico LA; Jiang Y; Carannante V; Iskrak S; Sandoz PA; Mikes J; Klymchenko A; Buggert M; Österborg A; Önfelt B; Brodin P; Sezgin E
Corrigendum: GENOME MEDICINE. 2024;16(1):6

Correction: Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.

Matuozzo D; Talouarn E; Marchal A; Zhang P; Manry J; Seeleuthner Y; Zhang Y; Bolze A; Chaldebas M; Milisavljevic B; Gervais A; Bastard P; Asano T; Bizien L; Barzaghi F; Abolhassani H; Tayoun AA; Aiuti A; Darazam IA; Allende LM; Alonso-Arias R; Arias AA; Aytekin G; Bergman P; Bondesan S; Bryceson YT; Bustos IG; Cabrera-Marante O; Carcel S; Carrera P; Casari G; Chaïbi K; Colobran R; Condino-Neto A; Covill LE; Delmonte OM; Zein LE; Flores C; Gregersen PK; Gut M; Haerynck F; Halwani R; Hancerli S; Hammarström L; Hatipoğlu N; Karbuz A; Keles S; Kyheng C; Leon-Lopez R; Franco JL; Mansouri D; Martinez-Picado J; Akcan OM; Migeotte I; Morange P-E; Morelle G; Martin-Nalda A; Novelli G; Novelli A; Ozcelik T; Palabiyik F; Pan-Hammarström Q; de Diego RP; Planas-Serra L; Pleguezuelo DE; Prando C; Pujol A; Reyes LF; Rivière JG; Rodriguez-Gallego C; Rojas J; Rovere-Querini P; Schlüter A; Shahrooei M; Sobh A; Soler-Palacin P; Tandjaoui-Lambiotte Y; Tipu I; Tresoldi C; Troya J; van de Beek D; Zatz M; Zawadzki P; Al-Muhsen SZ; Alosaimi MF; Alsohime FM; Baris-Feldman H; Butte MJ; Constantinescu SN; Cooper MA; Dalgard CL; Fellay J; Heath JR; Lau Y-L; Lifton RP; Maniatis T; Mogensen TH; von Bernuth H; Lermine A; Vidaud M; Boland A; Deleuze J-F; Nussbaum R; Kahn-Kirby A; Mentre F; Tubiana S; Gorochov G; Tubach F; Hausfater P; COVID Human Genetic Effort; COVIDeF Study Group; French COVID Cohort Study Group; CoV-Contact Cohort; COVID Clinicians; Orchestra Working Group; Amsterdam UMC Covid-19 Biobank; NIAID-USUHS COVID Study Group; Meyts I; Zhang S-Y; Puel A; Notarangelo LD; Boisson-Dupuis S; Su HC; Boisson B; Jouanguy E; Casanova J-L; Zhang Q; Abel L; Cobat A
Review: NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY. 2024;21(1):35-45

The maternal gut microbiome in pregnancy: implications for the developing immune system.

Koren O; Konnikova L; Brodin P; Mysorekar IU; Collado MC
Conference publication: 2023;00:715-720

Modelling Pathogen Response of the Human Immune System in a Reduced State Space

Tajvar P; Forlin R; Brodin P; Dimarogonas DV
Preprint: MEDRXIV. 2023

A systematic investigation into the non-genetic and genetic factors affecting the human anti-viral antibody repertoire

Olin A; Jaquaniello A; Tan Z; Pou C; Dubois F; Charbit B; Bloch E; White M; Rotival M; Brodin P; Duffy D; Patin E; Quintana-Murci L; Consortium MI
Review: SEMINARS IN IMMUNOLOGY. 2023;69:101794

Immune responses to SARS-CoV-2 infection and vaccination in children.

Brodin P
Review: TRENDS IN IMMUNOLOGY. 2023;44(8):577-584

Making human immune systems more interpretable through systems immunology.

Forlin R; James A; Brodin P
Preprint: BIORXIV. 2023

Scalablein-vitroimmunostimulation of human blood for in-depth profiling of acute immune response effects

Reitzner SM; Brodin P; Mikeš J
Preprint: BIORXIV. 2023

Molecular Pixelation: Single cell spatial proteomics by sequencing

Karlsson F; Kallas T; Thiagarajan D; Karlsson M; Schweitzer M; Navarro JF; Leijonancker L; Geny S; Pettersson E; Rhomberg-Kauert J; Granillo MG; Bunz J; Dahlberg J; Simonetti M; Sathe P; Brodin P; Barrio AM; Fredriksson S
Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;151(4):832-840

Inherited and acquired errors of type I interferon immunity govern susceptibility to COVID-19 and multisystem inflammatory syndrome in children.

Bucciol G; COVID Human Genetic Effort; Meyts I
Review: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2023;151(4):818-831

Impact of SARS-CoV-2 infection and COVID-19 on patients with inborn errors of immunity.

Tangye SG; COVID Human Genetic Effort consortium
Editorial comment: SCIENCE. 2023;379(6632):538-539

Exaggerated responses to a virus long gone.

Brodin P
Review: CAMB PRISM PRECIS MED. 2023;1:e25

Making inroads to precision medicine for the treatment of autoimmune diseases: Harnessing genomic studies to better diagnose and treat complex disorders.

Baglaenko Y; Wagner C; Bhoj VG; Brodin P; Gershwin ME; Graham D; Invernizzi P; Kidd KK; Korsunsky I; Levy M; Mammen AL; Nizet V; Ramirez-Valle F; Stites EC; Williams MS; Wilson M; Rose NR; Ladd V; Sirota M
Conference publication: JOURNAL OF IMMUNOLOGY. 2023;210(1)

Immune system perturbations in patients with severe long COVID

Rodriguez L; Tan Z; Lakshmikanth T; Wang J; Barcenilla H; Gonzalez L; Mugabo C; Johnsson A; Chen Y; Mikes J; Landegren N; Runold M; Bruchfeld J; Brodin P
Editorial comment: BMJ-BRITISH MEDICAL JOURNAL. 2022;379:o2750

The challenges of doing paediatric research during the first year of the covid-19 pandemic.

Buonsenso D; Roland D; Yock-Corrales A; González-Dambrauskas S; Brodin P; Santiago-Garcia B; Soriano-Arandes A; Koenraads M; De Luca D; Whittaker E
Editorial comment: JOURNAL OF CLINICAL IMMUNOLOGY. 2022;42(7):1354-1359

Decoding the Human Genetic and Immunological Basis of COVID-19 mRNA Vaccine-Induced Myocarditis.

Bolze A; Mogensen TH; Zhang S-Y; Abel L; Andreakos E; Arkin LM; Borghesi A; Brodin P; Hagin D; Novelli G; Okada S; Peter J; Renia L; Severe K; Tiberghien P; Vinh DC; COVID human genetic effort; Cirulli ET; Casanova J-L; Hsieh EWY
Letter: LANCET GASTROENTEROLOGY & HEPATOLOGY. 2022;7(7):594-595

Severe acute hepatitis in children: investigate SARS-CoV-2 superantigens.

Brodin P; Arditi M
Review: SCIENCE. 2022;376(6596):945-950

Immune-microbe interactions early in life: A determinant of health and disease long term.

Brodin P
Letter: NATURE MEDICINE. 2022;28(5):879-882

Studying severe long COVID to understand post-infectious disorders beyond COVID-19.

Brodin P; Casari G; Townsend L; O'Farrelly C; Tancevski I; Löffler-Ragg J; Mogensen TH; Casanova JL; COVID Human Genetic Effort
Preprint: BIORXIV. 2022

Data availability of open T-cell receptor repertoire data, a systematic assessment

Huang Y-N; Patel NA; Mehta JH; Ginjala S; Brodin P; Gray C; Patel Y; Cowell L; Burkhardt A; Mangul S
Review: NATURE. 2022;603(7902):587-598

Human genetic and immunological determinants of critical COVID-19 pneumonia.

Zhang Q; Bastard P; COVID Human Genetic Effort; Cobat A; Casanova J-L
Preprint: BIORXIV. 2022

Graph deep learning reveals multiple signal pathways activated in anti-citrullinated protein antibodies stimulated synoviocytes

Sun M; Chen Y; Brodin P; Catrina A
Preprint: RESEARCH SQUARE. 2022

Three adult cases of STAT1-gain-of-function with chronic mucocutaneous candidiasis treated with JAK inhibitors

Borgström EW; Edvinsson M; Perez LP; Norlin A-C; Hansen S; Fasth A; Friman V; Kämpe O; Månsson R; Tan Z; Smith CIE; Brodin P; Bergman P
Review: IMMUNITY. 2022;55(2):201-209

SARS-CoV-2 infections in children: Understanding diverse outcomes.

Brodin P
Corrigendum: NATURE IMMUNOLOGY. 2022;23(2):341

Author Correction: A global effort to dissect the human genetic basis of resistance to SARS-CoV-2 infection.

Andreakos E; Abel L; Vinh DC; Kaja E; Drolet BA; Zhang Q; O'Farrelly C; Novelli G; Rodríguez-Gallego C; Haerynck F; Prando C; Pujol A; COVID Human Genetic Effort; Su HC; Casanova J-L; Spaan AN
Preprint: MEDRXIV. 2022

Autoantibodies in COVID-19 correlate with anti-viral humoral responses and distinct immune signatures

Taeschler P; Cervia C; Zurbuchen Y; Hasler S; Pou C; Tan Z; Adamo S; Raeber ME; Bächli E; Rudiger A; Stüssi-Helbling M; Huber LC; Brodin P; Nilsson J; Probst-Müller E; Boyman O
Letter: JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2021;148(1):96-98

Severe COVID-19 in an APS1 patient with interferon autoantibodies treated with plasmapheresis.

Lemarquis A; Campbell T; Aranda-Guillén M; Hennings V; Brodin P; Kämpe O; Blennow K; Zetterberg H; Wennerås C; Eriksson K; Landegren N; Bryceson Y; Berg S; Ekwall O
Review: JOURNAL OF EXPERIMENTAL MEDICINE. 2021;218(6):e20210446

SARS-CoV-2-related MIS-C: A key to the viral and genetic causes of Kawasaki disease?

Sancho-Shimizu V; Brodin P; Cobat A; Biggs CM; Toubiana J; Lucas CL; Henrickson SE; Belot A; MIS-C@CHGE; Tangye SG; Milner JD; Levin M; Abel L; Bogunovic D; Casanova J-L; Zhang S-Y
Editorial comment: NATURE METHODS. 2021;18(6):588-591

Diversity in immunogenomics: the value and the challenge.

Peng K; Safonova Y; Shugay M; Popejoy AB; Rodriguez OL; Breden F; Brodin P; Burkhardt AM; Bustamante C; Cao-Lormeau V-M; Corcoran MM; Duffy D; Fuentes-Guajardo M; Fujita R; Greiff V; Jönsson VD; Liu X; Quintana-Murci L; Rossetti M; Xie J; Yaari G; Zhang W; Abedalthagafi MS; Adekoya KO; Ahmed RA; Chang W-C; Gray C; Nakamura Y; Lees WD; Khatri P; Alachkar H; Scheepers C; Watson CT; Karlsson Hedestam GB; Mangul S
Editorial comment: JOURNAL OF CLINICAL IMMUNOLOGY. 2020;40(7):958-959

Unraveling the Immune Response in Severe COVID-19.

Rodriguez L; Brodin P
Review: CURRENT OPINION IN IMMUNOLOGY. 2020;65:28-31

Technologies for assessing vaccine responses in the very young.

Brodin P
Editorial comment: CURRENT OPINION IN IMMUNOLOGY. 2020;65:iv

Editorial overview: Evolutionary and systems immunology - methods to understand human immune system variation.

Brodin P; Quintana-Murci L
Preprint: BIORXIV. 2020

Single-cell classification using learned cell phenotypes

Chen Y; Lakshmikanth T; Mikes J; Brodin P
Editorial comment: CELL. 2020;181(6):1194-1199

A Global Effort to Define the Human Genetics of Protective Immunity to SARS-CoV-2 Infection.

Casanova J-L; Su HC; COVID Human Genetic Effort
Editorial comment: ACTA PAEDIATRICA. 2020;109(6):1082-1083

Why is COVID-19 so mild in children?

Brodin P
Review: HUMAN GENETICS. 2020;139(6-7):795-799

New approaches to the study of immune responses in humans.

Brodin P
Editorial comment: CELL. 2020;180(5):820-821

Stressful Beginnings with Long-Term Consequences.

Consiglio CR; Brodin P
Review: JAMA PEDIATRICS. 2019;173(11):1032-1040

Association of Use of the Neonatal Early-Onset Sepsis Calculator With Reduction in Antibiotic Therapy and Safety: A Systematic Review and Meta-analysis.

Achten NB; Klingenberg C; Benitz WE; Stocker M; Schlapbach LJ; Giannoni E; Bokelaar R; Driessen GJA; Brodin P; Uthaya S; van Rossum AMC; Plötz FB
Editorial comment: NATURE MEDICINE. 2019;25(7):1026

Seeking the ultimate challenge.

Brodin P
Editorial comment: ACTA PAEDIATRICA. 2019;108(7):1357-1358

Leucocytosis is associated with retinopathy of prematurity in extremely preterm infants.

Lundgren P; Klevebro S; Brodin P; Smith LEH; Hallberg B; Hellström A
Letter: IMMUNITY. 2019;50(6):1335-1336

A Call for Blood-In Human Immunology.

Brodin P; Duffy D; Quintana-Murci L
Review: FEBS JOURNAL. 2019;286(8):1514-1522

The biology of the cell - insights from mass cytometry.

Brodin P
Editorial comment: NATURE REVIEWS IMMUNOLOGY. 2019;19(2):87-88

Systems-level patterns emerge.

Brodin P
Review: ANNUAL REVIEW OF IMMUNOLOGY. 2018;36:843-864

Rebooting Human Immunology.

Davis MM; Brodin P
Editorial comment: CELL HOST & MICROBE. 2017;21(3):309-310

Life-Saving Degeneracy in the Human Immune System.

Brodin P
Review: NATURE REVIEWS IMMUNOLOGY. 2017;17(1):21-29

Human immune system variation.

Brodin P; Davis MM
Review: TRENDS IN IMMUNOLOGY. 2016;37(3):233-243

Immune Adaptation to Environmental Influence: The Case of NK Cells and HCMV.

Rölle A; Brodin P
Editorial comment: IMMUNITY. 2015;43(6):1035-1037

Powerful Populations Respond to Viruses and Vaccines.

Brodin P
Thesis / dissertation: 2011

MHC class I molecules in natural killer cell education and tolerance

Brodin, Petter
Review: NATURE REVIEWS IMMUNOLOGY. 2010;10(10):724-734

Current perspectives of natural killer cell education by MHC class I molecules.

Höglund P; Brodin P
Review: TRENDS IN IMMUNOLOGY. 2009;30(4):143-149

NK cell education: not an on-off switch but a tunable rheostat.

Brodin P; Kärre K; Höglund P
Visa fler

Forskningsbidrag

Environmental imprinting of the Human Immune System Early in Life

Swedish Research Council

1 January 2023 - 31 December 2027
Post-acute Covid-19 syndrome: phenotyping and immunologic/genetic mechanisms

Swedish Research Council

1 December 2022 - 30 November 2025
Genetic and immunological determinants of severe post-acute COVID-19-syndrome

Swedish Research Council

1 December 2021 - 30 November 2024
The epidemiology, immunology and genetics of adverse reactions to COVID-19 vaccines

Swedish Research Council

1 June 2021 - 31 May 2024
Exploring immunologic and genetic factors in COVID-19 with relevance for respiratory disease; a new BAMSE follow-up

Swedish Heart-Lung Foundation

1 January 2021 - 31 December 2021
Personalized medicine to tackle immune dysfunction in refractory juvenile idiopathic arthritis

Swedish Research Council

1 January 2021 - 31 December 2023
Systems-level Immunomonitoring of children treated at Astrid Lindgren’s Children’s Hospital

Swedish Research Council

1 January 2021 - 31 December 2024
Shaping of Human Immune Systems by Environmental Influences Early in Life

Swedish Research Council

1 January 2020 - 31 December 2023
Utvecklingsbanor för humana B-celler

Knut and Alice Wallenberg Foundation

1 January 2020 - 1 January 2025
Immune reconstitution and therapy after heamatopoetic stem cell transplantation

Swedish Research Council

1 January 2019 - 31 December 2021
Simultaneous detection of protein, RNA and DNA in single immune cells

Swedish Research Council

1 December 2018 - 30 November 2023
ISAC - Immune System Against Cancer in Children: A New Platform for Increased Knowledge of the Immune System in Children with Cancer, Aiming to Accelerate the Introduction of Immunotherapy

Swedish Cancer Society

1 January 2018
The maturation of a well-balanced immune system determines the prognosis for patients with leukemia who undergo stem cell transplantation.

Swedish Cancer Society

1 January 2017
Quorum sensing in the human immune system

Swedish Research Council

1 January 2016 - 31 December 2019
The maturation of a well-balanced immune system determines the prognosis for patients with leukemia who undergo stem cell transplantation.

Swedish Cancer Society

1 January 2016
The maturation of a well-balanced immune system determines the prognosis for patients with leukemia who undergo stem cell transplantation.

Swedish Cancer Society

1 January 2015

Anställningar

Professor/Specialistläkare, Kvinnors och barns hälsa, Karolinska Institutet, 2021-

Examina och utbildning

Docent, Immunologi, Karolinska Institutet, 2018
Medicine Doktorsexamen, Institutionen för mikrobiologi, tumör- och cellbiologi, Karolinska Institutet, 2011
Läkarexamen, Karolinska Institutet, 2010

Priser och utmärkelser

Wallenberg Scholar, Knut and Alice Wallenberg Foundation, 2024
SSMF Consolidator award, Swedish Society for Medical Research, 2022
VR Consolidator award, Swedish Research Council, 2022
EMBO Young Investigator, European Molecular Biology Organization, 2019
Wallenberg Academy Fellow, Knut and Alice Wallenberg Foundation, 2019
Jonas Söderquist Scholarship, 2019
Member, Young Academy of Sweden, 2019
Göran Gustavsson award, Royal Swedish Academy of Sciences, 2019
The Sven and Ebba-Christina Hagberg Prize, By the Sven and Ebba-Christina Hagberg foundation, 2018
Wallenberg Clinical Fellow, Marianne and Marcus Wallenberg Foundation, 2017
ERC starting grant, European Research Council, 2015
VR young researcher grant, Swedish Research Council, 2015
SSMF young researcher grant, Swedish Society for Medical Research, 2014
Wenner-Gren Fellow, 2012
Prins Bertil's award, Sweden America Foundation, 2012
Doktorsexamen, 2009

Handledare

Hanna Danielsson, The role of early-life events on protein expression and gut microbiome in extreme preterm infants, 2020

Gästforskning och resestipendier

Postdoc, Stanford University School of Medicine, 2012-2013

Om mig

Artiklar

Alla övriga publikationer

Forskningsbidrag

Anställningar

Examina och utbildning

Priser och utmärkelser

Handledare

Gästforskning och resestipendier

Nyheter från KI

Kalenderhändelser från KI