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Artiklar

Article: NEUROBIOLOGY OF DISEASE. 2024;195:106484

Spatio-temporal brain invasion pattern of Streptococcus pneumoniae and dynamic changes in the cellular environment in bacteremia-derived meningitis.

Farmen K; Tofiño-Vian M; Wellfelt K; Olsson L; Iovino F
Article: ISCIENCE. 2024;27(4):109583

The single D380 amino acid substitution increases pneumolysin cytotoxicity towards neuronal cells

Serra S; Iannotti V; Ferrante M; Tofiño-Vian M; Baxendale J; Silberberg G; Kohler TP; Hammerschmidt S; Ulijasz AT; Iovino F
Article: JAMA NETWORK OPEN. 2024;7(1):e2352402

Increased Risk of Long-Term Disabilities Following Childhood Bacterial Meningitis in Sweden.

Mohanty S; Johansson Kostenniemi U; Silfverdal SA; Salomonsson S; Iovino F; Sarpong EM; Bencina G; Bruze G
Article: MBIO. 2022;13(5):e0188622-e01822

Dysfunctional Glymphatic System with Disrupted Aquaporin 4 Expression Pattern on Astrocytes Causes Bacterial Product Accumulation in the CSF during Pneumococcal Meningitis.

Generoso JS; Thorsdottir S; Collodel A; Dominguini D; Santo RRE; Petronilho F; Barichello T; Iovino F
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2022;119(23):e2122386119

Membrane particles evoke a serotype-independent cross-protection against pneumococcal infection that is dependent on the conserved lipoproteins MalX and PrsA.

Narciso AR; Iovino F; Thorsdottir S; Mellroth P; Codemo M; Spoerry C; Righetti F; Muschiol S; Normark S; Nannapaneni P; Henriques-Normark B
Article: PLOS PATHOGENS. 2021;17(3):e1009432

Neuronal death in pneumococcal meningitis is triggered by pneumolysin and RrgA interactions with β-actin.

Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Srambickal CV; Widengren J; Henriques-Normark B; Iovino F
Article: EMBO MOLECULAR MEDICINE. 2020;12(11):e12695

Mannose receptor-derived peptides neutralize pore-forming toxins and reduce inflammation and development of pneumococcal disease.

Subramanian K; Iovino F; Tsikourkitoudi V; Merkl P; Ahmed S; Berry SB; Aschtgen M-S; Svensson M; Bergman P; Sotiriou GA; Henriques-Normark B
Article: CHEMICAL COMMUNICATIONS. 2020;56(51):6989-6992

Silica-coated phosphorescent nanoprobes for selective cell targeting and dynamic bioimaging of pathogen-host cell interactions.

Iovino F; Merkl P; Spyrogianni A; Henriques-Normark B; Sotiriou GA
Article: BIOSENSORS & BIOELECTRONICS. 2019;132:286-293

Luminescent CeO2:Eu3+ nanocrystals for robust in situ H2O2 real-time detection in bacterial cell cultures.

Henning DF; Merkl P; Yun C; Iovino F; Xie L; Mouzourakis E; Moularas C; Deligiannakis Y; Henriques-Normark B; Leifer K; Sotiriou GA
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:195-202

IVIS Spectrum CT to Image the Progression of Pneumococcal Infections In Vivo.

Sierakowiak A; Henriques-Normark B; Iovino F
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:173-181

In Vivo Mouse Models to Study Pneumococcal Host Interaction and Invasive Pneumococcal Disease.

Iovino F; Sender V; Henriques-Normark B
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:53-59

High-Resolution and Super-Resolution Immunofluorescent Microscopy Ex Vivo to Study Pneumococcal Interactions with the Host.

Iovino F; Henriques-Normark B
Article: METHODS IN MOLECULAR BIOLOGY. 2019;1968:35-39

Immunofluorescent Staining and High-Resolution Microscopy to Study the Pneumococcal Cell.

Iovino F; Henriques-Normark B
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):476-484

Receptor Blockade: A Novel Approach to Protect the Brain From Pneumococcal Invasion.

Iovino F; Thorsdottir S; Henriques-Normark B
Article: MBIO. 2018;9(2):e00559-e00518

Immunomodulatory Effects of Pneumococcal Extracellular Vesicles on Cellular and Humoral Host Defenses.

Codemo M; Muschiol S; Iovino F; Nannapaneni P; Plant L; Wai SN; Henriques-Normark B
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2017;214(6):1619-1630

pIgR and PECAM-1 bind to pneumococcal adhesins RrgA and PspC mediating bacterial brain invasion.

Iovino F; Engelen-Lee J-Y; Brouwer M; van de Beek D; van der Ende A; Valls Seron M; Mellroth P; Muschiol S; Bergstrand J; Widengren J; Henriques-Normark B
Article: JOURNAL OF CLINICAL INVESTIGATION. 2016;126(8):2821-2826

Pneumococcal meningitis is promoted by single cocci expressing pilus adhesin RrgA.

Iovino F; Hammarlöf DL; Garriss G; Brovall S; Nannapaneni P; Henriques-Normark B
Article: INFECTION AND IMMUNITY. 2014;82(9):3555-3566

Platelet endothelial cell adhesion molecule-1, a putative receptor for the adhesion of Streptococcus pneumoniae to the vascular endothelium of the blood-brain barrier.

Iovino F; Molema G; Bijlsma JJE
Article: MBIO. 2014;5(4):e00984-e00914

The proteasome-ubiquitin system is required for efficient killing of intracellular Streptococcus pneumoniae by brain endothelial cells.

Iovino F; Gradstedt H; Bijlsma JJ
Article: PLOS ONE. 2014;9(5):e97914

Streptococcus pneumoniae Interacts with pIgR expressed by the brain microvascular endothelium but does not co-localize with PAF receptor.

Iovino F; Molema G; Bijlsma JJE
Article: PLOS ONE. 2013;8(7):e68408

Interactions between blood-borne Streptococcus pneumoniae and the blood-brain barrier preceding meningitis.

Iovino F; Orihuela CJ; Moorlag HE; Molema G; Bijlsma JJE
Article: PLOS ONE. 2013;8(6):e65626

Streptococcus pneumoniae invades endothelial host cells via multiple pathways and is killed in a lysosome dependent manner.

Gradstedt H; Iovino F; Bijlsma JJE
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Alla övriga publikationer

Preprint: BIORXIV. 2023

Spatio-temporal brain invasion pattern of Streptococcus pneumoniae and dynamic changes of the cellular environment in meningitis pathogenesis

Farmen K; Tofiño-Vian M; Wellfelt K; Olson L; Iovino F
Review: FRONTIERS IN NEUROLOGY. 2023;14:822575

Bacterial meningitis in Africa.

Barichello T; Rocha Catalão CH; Rohlwink UK; van der Kuip M; Zaharie D; Solomons RS; van Toorn R; Tutu van Furth M; Hasbun R; Iovino F; Namale VS
Book: 2022

Encyclopedia of Infection and Immunity
Preprint: BIORXIV. 2022

Dysfunctional glymphatic system with disrupted aquaporin-4 expression pattern on astrocytes causes bacterial product accumulation in the CSF during pneumococcal meningitis

Generoso JS; Thorsdottir S; Collodel A; Dominguini D; Santo RRE; Petronilho F; Barichello T; Iovino F
Editorial comment: AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE. 2021;203(5):539-540

Experimental Model for Studies of Pneumococcal Colonization in Older Adults.

Iovino F; Henriques-Normark B
Review: FRONTIERS IN CELLULAR NEUROSCIENCE. 2021;15:680858

Neuronal Damage and Neuroinflammation, a Bridge Between Bacterial Meningitis and Neurodegenerative Diseases.

Farmen K; Tofiño-Vian M; Iovino F
Editorial comment: FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY. 2021;11:790761

Editorial: Host-Pathogen Interaction in the Central Nervous System.

Barichello T; Iovino F
Preprint: BIORXIV. 2020

Neuronal death in pneumococcal meningitis is triggered by pneumolysin and pilus-1 interactions with β-actin

Tabusi M; Thorsdottir S; Lysandrou M; Narciso AR; Minoia M; Henriques-Normark B; Iovino F
Review: MOLECULAR MICROBIOLOGY. 2020;113(3):650-658

The impact of the ancillary pilus-1 protein RrgA of Streptococcus pneumoniae on colonization and disease.

Iovino F; Nannapaneni P; Henriques-Normark B; Normark S
Book: 2019

Streptococcus pneumoniae Methods and Protocols

Iovino F
Review: FRONTIERS IN MICROBIOLOGY. 2019;10:576

The Role of Microglia in Bacterial Meningitis: Inflammatory Response, Experimental Models and New Neuroprotective Therapeutic Strategies.

Thorsdottir S; Henriques-Normark B; Iovino F
Review: TRENDS IN MICROBIOLOGY. 2016;24(4):307-315

How Does Streptococcus pneumoniae Invade the Brain?

Iovino F; Seinen J; Henriques-Normark B; van Dijl JM
Review: CELLULAR MICROBIOLOGY. 2013;15(6):870-881

Signalling or binding: the role of the platelet-activating factor receptor in invasive pneumococcal disease.

Iovino F; Brouwer MC; van de Beek D; Molema G; Bijlsma JJE

Forskningsbidrag

Medicin 2025, projektmedel

ALF (Region Stockholm)

1 January 2025 - 31 December 2024
Etablering av en ny neuroprotektiv terapi för att förhindra hörselnedsättning orsakad av hjärninfektioner

Etablering av en ny neuroprotektiv terapi för att förhindra hörselnedsättning orsakad av hjärninfektioner

1 June 2024
Supporting innovators to fight drug-resistant infections

INCATE

1 May 2024
Blockering av bakteriell interaktion med neuroner: en ny terapeutisk strategi för att förhindra permanent neurologisk skada orsakad av hjärninfektioner

Magnus Bergvall Foundation

1 February 2024
The bacteria-neuron blockade, the FIRST therapeutic approach to prevent permanent neurological damage caused by infections

Gun & Bertil Stohnes Stiftelse

1 January 2024
Förebyggande av neurologiska funktionshinder orsakade av perinatala hjärninfektioner

Åhlén-stiftelsen

1 January 2024
Novel fusion proteins with bacteriocidic, anti-neurotoxic and antibiotic synergistic properties to improve pneumococcal meningitis treatment

H.K.H. Kronprinsessan Lovisas förening för barnasjukvård

1 November 2023 - 1 November 2024
Förhindra permanent allvarlig hörselnedsättning orsakad av hjärninfektioner

Stiftelsen Tysta Skolan

1 May 2023
Bakteriell interaktion med neuroner: ett nytt terapeutiskt mål mot hjärninfektioner

Magnus Bergvalls Stiftelse

1 February 2023
En ny terapeutisk metod för att förhindra permanent neurologisk funktionsnedsättning hos spädbarn och barn som drabbats av hjärninfektioner

Wera Ekströms stiftelse för pediatrisk forskning

1 February 2023
Blockade of pneumococcal‐neuron interaction to prevent neuronal damage in bacterial meningitis

European Society of Clinical Microbiology and Infectious Diseases

1 January 2023 - 1 January 2024
Establishment of the first therapeutic approach to prevent permanent neurological disabilities caused by brain bacterial infections

Bjarne Alhströms Minnesfond

1 January 2023
Förebyggande av neurologiska funktionshinder orsakade av perinatala hjärninfektioner

Åhlén-stiftelsen

1 January 2023
Bakteriell interaktion med neuroner: ett nytt terapeutiskt mål mot hjärninfektioner

Magnus Bergvalls Stiftelse

1 January 2022
Förhindra irreparabel neurologisk skada efter bakteriell meningit genom att blockera patogeninteraktion med neuroner

Tore Nilsons Stiftelse

1 January 2022
Förhindra neuronal förlust som leder till Parkinsons och Alzheimers sjukdomar

Stiftelsen för Gamla Tjänarinnor

1 May 2021
Bacterial meningitis: Understanding bacterial interactions with neurons and microglia to develop new approaches to prevent neuronal damage and reinforce the brain´s immune system.

Swedish Research Council

1 January 2021 - 31 December 2024
Förhindra irreparabel neurologisk skada efter bakteriell meningit genom att blockera patogeninteraktion med neuroner

Magnus Bergvalls Stiftelse

1 January 2021
Bakteriell meningit: Förstå bakteriella interaktioner med mikroglia och nervceller för att utveckla nya metoder för att öka hjärnans immunsystem och förhindra neuronal skada

Tore Nilsons Stiftelse

1 January 2021
Understanding bacterial invasion of the brain: Interactions of Streptococcus pneumoniae with microglia and neurons.

Åke Wiberg Foundation

1 January 2020
Understanding bacterial invasion of the brain

Loo & Hans Osterman Foundation

1 November 2019
Start-up Grant

StratNeuro

1 June 2019
Block pneumococcal-neuron interaction to protect neurons from bacterial infections

Clas Groschinskys Minnesfond

1 June 2019
Bakteriell meningit: Förstå bakteriella interaktioner med mikroglia och nervceller för att utveckla nya metoder för att öka hjärnans immunsystem och förhindra neuronal skada

Petrus and Augusta Hedlund Foundation

1 June 2019
Förbättra antimikrobiella behandlingar hos cancerpatienter.

Jeanssons Stiftelser

1 January 2019
New therapeutic and prophylactic strategies to cure and prevent bacterial meningitis

HKH Kronprinsessan Lovisas förening för barnasjukvård

1 January 2019
New therapeutic strategies to cure and prevent bacterial meningitis State

Karolinska Institutet Research Foundations

1 January 2019
Brain cancer and bacterial meningitis: how to prevent bacterial penetration of the blood-brain barrier in patients with brain cancer.

Åke Wibergs Stiftelse

1 January 2019
Faculty-funded Assistant Professor position

Karolinska Institutet

3 December 2018
Bakteriell meningit: Molekylära mekanismer för bakteriell inträde i hjärnan över blod-hjärnbarriären och nya terapeutiska metoder för att blockera det.

Petrus och Augusta Hedlunds Stiftelse

1 June 2018
Bacterial meningitis: Understanding bacterial invasion of the brain

Fredrik och Ingrid Thurings Stiftelse

1 January 2018
New therapeutic strategies to cure and prevent bacterial meningitis

Jeanssons Stiftelser

1 January 2018
New therapeutic strategies to cure and prevent bacterial meningitis

Åke Wibergs Stiftelse

1 January 2018
Etablering av en ny neuroprotektiv terapi för att förhindra hörselnedsättning orsakad av hjärninfektioner

Stiftelsen Tysta Skolan
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Anställningar

Senior Forskare, Neurovetenskap, Karolinska Institutet, 2023-
Postdoctoral researcher, Microbiology, Tumor and Cell Biology (MTC), Karolinska Institutet, 2013-2015

Examina och utbildning

Docent, Medicinsk mikrobiologi, Karolinska Institutet, 2021
PhD degree, Medical Microbiology, Medical Microbiology, University of Groningen, 2013

Uppdrag

Sektionsansvarig, Principal Investigator representative, Neuroscience, Karolinska Institute, 2022-
Sektionsansvarig, Safety representative, Neuroscience, Karolinska Institute, 2022-

Priser och utmärkelser

World Expert Recognition, Expertscape, https://nyheter.ki.se/federico-iovino-utsedd-till-world-expert-av-expertscape, 2021
Prize for research in Clinical Neurology, Bjarne Ahlström Memorial Fund, https://news.ki.se/federico-iovino-awarded-the-bjarne-ahlstrom-minnesfonds-pris-2020-for-research-in-clinical, 2020

Handledare

Niels Vander Elst, 2023
Simona Serra, 2023
Miguel Tofiño-Vian, 2021
Kristine Farmen, 2021

Redaktör för vetenskaplig tidskrift

"In vitro and In vivo models for CNS infections", part of the “Methods in Molecular Biology” series, Chefredaktör, 2022
Frontiers in Cellular and Infection Microbiology, Medlem i redaktionskommittén, 2021
Section Clinical Infectious Diseases, Encyclopedia of Infection and Immunity (Elsevier), Biträdande redaktör, https://www.sciencedirect.com/referencework/9780323903035/encyclopedia-of-infection-and-immunity, 2020
"Streptococcus pneumoniae", part of the “Methods in Molecular Biology” series, Chefredaktör, https://www.springer.com/gp/book/9781493991983, 2018

Sakkunniggranskning för vetenskaplig tidskrift

Nature Communications, Cell Systems, PNAS, eBioMedicine (The Lancet), Scientific Reports (Nature publishing group), BMC Journal of Biomedical Science, PLOS One, Journal of Neuroinflammation, Molecular Neurobiology, Brain Research, Cellular and Molecular Neurobiology, Journal of Neuroimmunology, Neurotoxicology and Teratology, Neuroscience Letters, Journal of Innate Immunity, Journal of Immunology, mBio (American Society of Microbiology), PLOS Pathogens, Infection & Immunity, Molecular Microbiology, Journal of Bacteriology, The International Journal of Medical Microbiology, Microbiology (Microbiology Society), Microbial Pathogenesis, Pathogens and Disease (FEMS), Virulence, Frontiers in Cellular and Infection Microbiology, Frontiers in Immunology, Frontiers in Pediatrics, Frontiers in Bioengineering and Biotechnology, Current Research in Microbial Sciences, Infection and Drug Resistance, Heliyon (Cell Press), Experimental and Molecular Pathology, Annals of Medicine, BMJ (British Medical Journal) Case Reports, Journal of Pediatric Infectious Disease Society., Anonymous peer review, 2018

Expert

Evaluator of research applications in international competition, Grant reviewer / Evaluation panel member, European Society of Clinical Microbiology and Infectious Diseases, 2021

Nyheter från KI

Kalenderhändelser från KI